GID	ORF	NAME	GWEIGHT	ARCHAEA	BACTERIA	PLANTS	NON-CHORDATES	CHORDATES	FUNGI	EUKARYOTIC PARASITES
EWEIGHT				1	1	1	1	1	1	1
1_OG5_126641_0 - ALL_YIL018W	YIL018W	"RPL2B - Protein component of the large (60S) ribosomal subunit, identical to Rpl2Ap and has similarity to E. coli L2 and rat L8 ribosomal proteins; expression is upregulated at low temperatures"	1	1	1	1	1	1	1	1
2_OG5_126641_0 - ALL_YEL050C	YEL050C	"RML2 - Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L2 ribosomal protein; fat21 mutant allele causes inability to utilize oleate and may interfere with activity of the Adr1p transcription factor"	1	1	1	1	1	1	1	1
3_OG5_126641_0 - ALL_YFR031C-A	YFR031C-A	"RPL2A - Protein component of the large (60S) ribosomal subunit, identical to Rpl2Bp and has similarity to E. coli L2 and rat L8 ribosomal proteins"	1	1	1	1	1	1	1	1
4_OG5_126681_0 - ALL_YCR031C	YCR031C	"RPS14A - Ribosomal protein 59 of the small subunit, required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; nearly identical to Rps14Bp and similar to E. coli S11 and rat S14 ribosomal proteins"	1	1	1	1	1	1	1	0.875
5_OG5_126681_0 - ALL_YJL191W	YJL191W	"RPS14B - Ribosomal protein 59 of the small subunit, required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; nearly identical to Rps14Ap and similar to E. coli S11 and rat S14 ribosomal proteins"	1	1	1	1	1	1	1	0.875
6_OG5_126687_0 - ALL_YNR037C	YNR037C	"RSM19 - Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S19 ribosomal protein"	1	1	1	1	1	1	1	0.9375
7_OG5_126687_0 - ALL_YOL040C	YOL040C	RPS15 - Protein component of the small (40S) ribosomal subunit; has similarity to E. coli S19 and rat S15 ribosomal proteins	1	1	1	1	1	1	1	0.9375
8_OG5_126688_0 - ALL_YDR237W	YDR237W	MRPL7 - Mitochondrial ribosomal protein of the large subunit	1	1	1	1	1	1	1	1
9_OG5_126688_0 - ALL_YGR085C	YGR085C	"RPL11B - Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl11Ap; involved in ribosomal assembly; depletion causes degradation of proteins and RNA of the 60S subunit; has similarity to E. coli L5 and rat L11"	1	1	1	1	1	1	1	1
10_OG5_126688_0 - ALL_YPR102C	YPR102C	"RPL11A - Protein of the large 60S ribosomal subunit, nearly identical to Rpl11Bp but expressed at twice the level; involved in ribosomal assembly; depletion causes degradation of 60S proteins and RNA; similar to E. coli L5 and rat L11"	1	1	1	1	1	1	1	1
11_OG5_126700_0 - ALL_YNL292W	YNL292W	"PUS4 - Pseudouridine synthase, catalyzes only the formation of pseudouridine-55 (Psi55), a highly conserved tRNA modification, in mitochondrial and cytoplasmic tRNAs; PUS4 overexpression leads to translational derepression of GCN4 (Gcd- phenotype)"	1	1	0.972222222	1	1	1	1	1
12_OG5_126700_0 - ALL_YLR175W	YLR175W	"CBF5 - Pseudouridine synthase catalytic subunit of box H/ACA small nucleolar ribonucleoprotein particles (snoRNPs), acts on both large and small rRNAs and on snRNA U2; mutations in human ortholog dyskerin cause the disorder dyskeratosis congenita"	1	1	0.972222222	1	1	1	1	1
13_OG5_126684_0 - ALL_YPL040C	YPL040C	"ISM1 - Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth"	1	1	1	1	0.952380952	1	1	1
14_OG5_126684_0 - ALL_YBL076C	YBL076C	"ILS1 - Cytoplasmic isoleucine-tRNA synthetase, target of the G1-specific inhibitor reveromycin A"	1	1	1	1	0.952380952	1	1	1
15_OG5_126710_0 - ALL_YDL104C	YDL104C	"QRI7 - Highly conserved mitochondrial protein, essential for t6A modification of mitochondrial tRNAs that decode ANN codons; similar to Kae1p and E. coli YgjD, both of which are also required for tRNA t6A modification"	1	1	1	1	0.952380952	1	1	0.9375
16_OG5_126710_0 - ALL_YKR038C	YKR038C	"KAE1 - Highly conserved ATPase of HSP70/DnaK family; component of the EKC/KEOPS complex with Bud32p, Cgi121p, Pcc1p, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription"	1	1	1	1	0.952380952	1	1	0.9375
17_OG5_126752_0 - ALL_YHR091C	YHR091C	MSR1 - Mitochondrial arginyl-tRNA synthetase	1	1	1	1	0.952380952	1	1	1
18_OG5_126752_0 - ALL_YDR341C	YDR341C	"YDR341C - Arginyl-tRNA synthetase, proposed to be cytoplasmic but the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"	1	1	1	1	0.952380952	1	1	1
19_OG5_126764_0 - ALL_YIL078W	YIL078W	"THS1 - Threonyl-tRNA synthetase, essential cytoplasmic protein"	1	1	1	1	0.952380952	1	1	1
20_OG5_126799_0 - ALL_YOR335C	YOR335C	"ALA1 - Cytoplasmic and mitochondrial alanyl-tRNA synthetase, required for protein synthesis; point mutation (cdc64-1 allele) causes cell cycle arrest at G1; lethality of null mutation is functionally complemented by human homolog"	1	1	1	1	0.952380952	1	1	1
21_OG5_126806_0 - ALL_YPR033C	YPR033C	HTS1 - Cytoplasmic and mitochondrial histidine tRNA synthetase; efficient mitochondrial localization requires both a presequence and an amino-terminal sequence; mutations in human ortholog HARS2 are associated with Perrault syndrome	1	1	1	1	0.952380952	1	1	1
22_OG5_126760_0 - ALL_YHL015W	YHL015W	RPS20 - Protein component of the small (40S) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; has similarity to E. coli S10 and rat S20 ribosomal proteins	1	1	0.972222222	1	1	1	0.95	0.875
23_OG5_126637_0 - ALL_YDL140C	YDL140C	"RPO21 - RNA polymerase II largest subunit B220, part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime"	1	1	0.916666667	1	1	1	1	1
24_OG5_126637_0 - ALL_YOR116C	YOR116C	"RPO31 - RNA polymerase III largest subunit C160, part of core enzyme; similar to bacterial beta-prime subunit and to RPA190 and RPO21"	1	1	0.916666667	1	1	1	1	1
25_OG5_126708_0 - ALL_YKL067W	YKL067W	"YNK1 - Nucleoside diphosphate kinase, catalyzes the transfer of gamma phosphates from nucleoside triphosphates, usually ATP, to nucleoside diphosphates by a mechanism that involves formation of an autophosphorylated enzyme intermediate"	1	1	0.944444444	1	0.952380952	1	1	0.875
26_OG5_126736_0 - ALL_YLR234W	YLR234W	"TOP3 - DNA Topoisomerase III, conserved protein that functions in a complex with Sgs1p and Rmi1p to relax single-stranded negatively-supercoiled DNA preferentially, involved in telomere stability and regulation of mitotic recombination"	1	0.9375	1	1	0.952380952	1	1	0.9375
27_OG5_126755_0 - ALL_YNL247W	YNL247W	"YNL247W - Cysteinyl-tRNA synthetase; may interact with ribosomes, based on co-purification experiments"	1	0.9375	1	1	0.952380952	1	1	0.9375
28_OG5_126678_0 - ALL_YBL087C	YBL087C	"RPL23A - Protein component of the large (60S) ribosomal subunit, identical to Rpl23Bp and has similarity to E. coli L14 and rat L23 ribosomal proteins"	1	1	1	1	0.952380952	0.928571429	1	1
29_OG5_126678_0 - ALL_YKL170W	YKL170W	MRPL38 - Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels	1	1	1	1	0.952380952	0.928571429	1	1
30_OG5_126678_0 - ALL_YER117W	YER117W	"RPL23B - Protein component of the large (60S) ribosomal subunit, identical to Rpl23Ap and has similarity to E. coli L14 and rat L23 ribosomal proteins"	1	1	1	1	0.952380952	0.928571429	1	1
31_OG5_126722_0 - ALL_YGL123W	YGL123W	"RPS2 - Protein component of the small (40S) subunit, essential for control of translational accuracy; phosphorylation by C-terminal domain kinase I (CTDK-I) enhances translational accuracy; methylated on one or more arginine residues by Hmt1p"	1	1	1	1	0.952380952	0.928571429	1	1
32_OG5_126723_0 - ALL_YGR094W	YGR094W	VAS1 - Mitochondrial and cytoplasmic valyl-tRNA synthetase	1	1	1	1	0.952380952	0.928571429	1	0.9375
33_OG5_127036_0 - ALL_YFL022C	YFL022C	"FRS2 - Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate binding is similar"	1	1	1	1	0.952380952	0.928571429	1	0.875
34_OG5_126677_0 - ALL_YHR011W	YHR011W	"DIA4 - Probable mitochondrial seryl-tRNA synthetase, mutant displays increased invasive and pseudohyphal growth"	1	0.875	1	1	1	1	1	1
35_OG5_126677_0 - ALL_YDR023W	YDR023W	"SES1 - Cytosolic seryl-tRNA synthetase, class II aminoacyl-tRNA synthetase that aminoacylates tRNA(Ser), displays tRNA-dependent amino acid recognition which enhances discrimination of the serine substrate, interacts with peroxin Pex21p"	1	0.875	1	1	1	1	1	1
36_OG5_126863_0 - ALL_YPR088C	YPR088C	"SRP54 - Signal recognition particle (SRP) subunit (homolog of mammalian SRP54); contains the signal sequence-binding activity of SRP, interacts with the SRP RNA, and mediates binding of SRP to signal receptor; contains GTPase domain"	1	0.9375	0.972222222	1	0.952380952	1	1	1
37_OG5_126851_0 - ALL_YJR103W	YJR103W	"URA8 - Minor CTP synthase isozyme (see also URA7), catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis"	1	0.9375	1	1	0.904761905	1	1	0.875
38_OG5_126851_0 - ALL_YBL039C	YBL039C	"URA7 - Major CTP synthase isozyme (see also URA8), catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis"	1	0.9375	1	1	0.904761905	1	1	0.875
39_OG5_126620_0 - ALL_YIL003W	YIL003W	"CFD1 - Highly conserved, iron-sulfur cluster binding protein localized in the cytoplasm; forms a complex with Nbp35p that is involved in iron-sulfur protein assembly in the cytosol"	1	0.9375	0.944444444	1	0.952380952	1	1	0.9375
40_OG5_126620_0 - ALL_YGL091C	YGL091C	NBP35 - Essential iron-sulfur cluster binding protein localized in the cytoplasm; forms a complex with Cfd1p that is involved in iron-sulfur protein assembly in the cytosol; similar to P-loop NTPases	1	0.9375	0.944444444	1	0.952380952	1	1	0.9375
41_OG5_126776_0 - ALL_YCR012W	YCR012W	"PGK1 - 3-phosphoglycerate kinase, catalyzes transfer of high-energy phosphoryl groups from the acyl phosphate of 1,3-bisphosphoglycerate to ADP to produce ATP; key enzyme in glycolysis and gluconeogenesis"	1	0.9375	0.944444444	1	0.952380952	1	1	0.9375
42_OG5_126659_0 - ALL_YOL127W	YOL127W	"RPL25 - Primary rRNA-binding ribosomal protein component of the large (60S) ribosomal subunit, has similarity to E. coli L23 and rat L23a ribosomal proteins; binds to 25S rRNA via a conserved C-terminal motif"	1	1	1	1	0.952380952	0.928571429	0.95	0.9375
43_OG5_126745_0 - ALL_YPL266W	YPL266W	"DIM1 - Essential 18S rRNA dimethylase (dimethyladenosine transferase), responsible for conserved m6(2)Am6(2)A dimethylation in 3'-terminal loop of 18S rRNA, part of 90S and 40S pre-particles in nucleolus, involved in pre-ribosomal RNA processing"	1	0.875	1	1	0.952380952	1	1	0.9375
44_OG5_126820_0 - ALL_YNL178W	YNL178W	"RPS3 - Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; has similarity to E. coli S3 and rat S3 ribosomal proteins"	1	1	1	0.875	0.952380952	1	1	0.9375
45_OG5_126913_0 - ALL_YAL015C	YAL015C	NTG1 - DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress	1	1	1	0.875	0.952380952	1	1	0.9375
46_OG5_126913_0 - ALL_YOL043C	YOL043C	"NTG2 - DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase involved in base excision repair, localizes to the nucleus; sumoylated"	1	1	1	0.875	0.952380952	1	1	0.9375
47_OG5_126908_0 - ALL_YNL072W	YNL072W	"RNH201 - Ribonuclease H2 catalytic subunit, removes RNA primers during Okazaki fragment synthesis and errant ribonucleotides misincorporated during DNA replication; homolog of RNAse HI; related to human AGS4 which causes Aicardi-Goutieres syndrome"	1	1	0.944444444	1	0.952380952	0.928571429	1	1
48_OG5_126730_0 - ALL_YHL011C	YHL011C	"PRS3 - 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes"	1	0.9375	0.916666667	1	0.952380952	1	1	0.8125
49_OG5_126730_0 - ALL_YBL068W	YBL068W	"PRS4 - 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes"	1	0.9375	0.916666667	1	0.952380952	1	1	0.8125
50_OG5_126730_0 - ALL_YER099C	YER099C	"PRS2 - 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes"	1	0.9375	0.916666667	1	0.952380952	1	1	0.8125
51_OG5_126970_0 - ALL_YJR069C	YJR069C	"HAM1 - Conserved protein with deoxyribonucleoside triphosphate pyrophosphohydrolase activity, mediates exclusion of noncanonical purines from deoxyribonucleoside triphosphate pools; mutant is sensitive to the base analog 6-N-hydroxylaminopurine"	1	0.9375	0.916666667	1	0.952380952	1	1	0.875
52_OG5_126777_0 - ALL_YMR101C	YMR101C	SRT1 - Cis-prenyltransferase involved in synthesis of long-chain dolichols (19-22 isoprene units; as opposed to Rer2p which synthesizes shorter-chain dolichols); localizes to lipid bodies; transcription is induced during stationary phase	1	0.9375	1	1	0.857142857	1	1	0.9375
53_OG5_126777_0 - ALL_YBR002C	YBR002C	RER2 - Cis-prenyltransferase involved in dolichol synthesis; participates in endoplasmic reticulum (ER) protein sorting	1	0.9375	1	1	0.857142857	1	1	0.9375
54_OG5_126932_0 - ALL_YDR292C	YDR292C	"SRP101 - Signal recognition particle (SRP) receptor alpha subunit; contain GTPase domains; involved in SRP-dependent protein targeting; interacts with the beta subunit, Srp102p"	1	0.9375	0.972222222	1	0.952380952	0.928571429	1	1
55_OG5_126698_0 - ALL_YGR254W	YGR254W	"ENO1 - Enolase I, a phosphopyruvate hydratase that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression is repressed in response to glucose"	1	0.9375	0.944444444	1	0.904761905	1	1	0.8125
56_OG5_126698_0 - ALL_YHR174W	YHR174W	"ENO2 - Enolase II, a phosphopyruvate hydratase that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression is induced in response to glucose"	1	0.9375	0.944444444	1	0.904761905	1	1	0.8125
57_OG5_126698_0 - ALL_YMR323W	YMR323W	"ERR3 - Protein of unknown function, has similarity to enolases"	1	0.9375	0.944444444	1	0.904761905	1	1	0.8125
58_OG5_126698_0 - ALL_YOR393W	YOR393W	"ERR1 - Protein of unknown function, has similarity to enolases"	1	0.9375	0.944444444	1	0.904761905	1	1	0.8125
59_OG5_126698_0 - ALL_YPL281C	YPL281C	"ERR2 - Protein of unknown function, has similarity to enolases"	1	0.9375	0.944444444	1	0.904761905	1	1	0.8125
60_OG5_126842_0 - ALL_YKL104C	YKL104C	"GFA1 - Glutamine-fructose-6-phosphate amidotransferase, catalyzes the formation of glucosamine-6-P and glutamate from fructose-6-P and glutamine in the first step of chitin biosynthesis"	1	0.875	0.944444444	1	0.952380952	1	1	0.9375
61_OG5_126848_0 - ALL_YGL169W	YGL169W	"SUA5 - Single-stranded telomeric DNA-binding protein, required for normal telomere length; null mutant lacks N6-threonylcarbamoyl adenosine (t6A) modification in the anticodon loop of ANN-decoding tRNA; member of conserved YrdC/Sua5 family"	1	0.9375	0.944444444	1	0.952380952	0.928571429	1	0.9375
62_OG5_126697_0 - ALL_YJL060W	YJL060W	"BNA3 - Kynurenine aminotransferase, catalyzes formation of kynurenic acid from kynurenine; potential Cdc28p substrate"	1	0.9375	0.916666667	1	0.904761905	1	1	0.375
63_OG5_126920_0 - ALL_YJR057W	YJR057W	"CDC8 - Thymidylate and uridylate kinase, functions in de novo biosynthesis of pyrimidine deoxyribonucleotides; converts dTMP to dTDP and dUMP to dUTP; essential for mitotic and meiotic DNA replication; homologous to S. pombe Tmp1p"	1	0.875	0.972222222	1	0.904761905	1	1	1
64_OG5_126593_0 - ALL_YML028W	YML028W	"TSA1 - Thioredoxin peroxidase, acts as both a ribosome-associated and free cytoplasmic antioxidant; self-associates to form a high-molecular weight chaperone complex under oxidative stress; deletion results in mutator phenotype"	1	0.875	0.916666667	1	0.952380952	1	1	0.9375
65_OG5_126593_0 - ALL_YDR453C	YDR453C	"TSA2 - Stress inducible cytoplasmic thioredoxin peroxidase; cooperates with Tsa1p in the removal of reactive oxygen, nitrogen and sulfur species using thioredoxin as hydrogen donor; deletion enhances the mutator phenotype of tsa1 mutants"	1	0.875	0.916666667	1	0.952380952	1	1	0.9375
66_OG5_126593_0 - ALL_YBL064C	YBL064C	"PRX1 - Mitochondrial peroxiredoxin (1-Cys Prx) with thioredoxin peroxidase activity, has a role in reduction of hydroperoxides; reactivation requires Trr2p and glutathione; induced during respiratory growth and oxidative stress; phosphorylated"	1	0.875	0.916666667	1	0.952380952	1	1	0.9375
67_OG5_126668_0 - ALL_YML026C	YML026C	RPS18B - Protein component of the small (40S) ribosomal subunit; nearly identical to Rps18Ap and has similarity to E. coli S13 and rat S18 ribosomal proteins	1	1	1	1	0.952380952	0.785714286	1	1
68_OG5_126668_0 - ALL_YDR450W	YDR450W	RPS18A - Protein component of the small (40S) ribosomal subunit; nearly identical to Rps18Bp and has similarity to E. coli S13 and rat S18 ribosomal proteins	1	1	1	1	0.952380952	0.785714286	1	1
69_OG5_126668_0 - ALL_YNL081C	YNL081C	"SWS2 - Putative mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S13 ribosomal protein; participates in controlling sporulation efficiency"	1	1	1	1	0.952380952	0.785714286	1	1
70_OG5_126679_0 - ALL_YLR058C	YLR058C	"SHM2 - Cytosolic serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; major isoform involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis"	1	0.875	1	1	0.857142857	1	1	0.875
71_OG5_126679_0 - ALL_YBR263W	YBR263W	"SHM1 - Mitochondrial serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis; reverse reaction generates serine"	1	0.875	1	1	0.857142857	1	1	0.875
72_OG5_126665_0 - ALL_YBL055C	YBL055C	YBL055C - 3'-->5' exonuclease and endonuclease with a possible role in apoptosis; has similarity to mammalian and C. elegans apoptotic nucleases	1	0.75	1	1	0.952380952	1	1	1
73_OG5_127076_0 - ALL_YHR074W	YHR074W	"QNS1 - Glutamine-dependent NAD(+) synthetase, essential for the formation of NAD(+) from nicotinic acid adenine dinucleotide"	1	0.9375	0.888888889	1	0.857142857	1	1	0.5625
74_OG5_126793_0 - ALL_YEL021W	YEL021W	"URA3 - Orotidine-5'-phosphate (OMP) decarboxylase, catalyzes the sixth enzymatic step in the de novo biosynthesis of pyrimidines, converting OMP into uridine monophosphate (UMP); converts 5-FOA into 5-fluorouracil, a toxic compound"	1	0.9375	0.916666667	1	0.857142857	0.928571429	1	0.6875
75_OG5_126793_0 - ALL_YML106W	YML106W	"URA5 - Major orotate phosphoribosyltransferase (OPRTase) isozyme that catalyzes the fifth enzymatic step in de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; minor OPRTase encoded by URA10"	1	0.9375	0.916666667	1	0.857142857	0.928571429	1	0.6875
76_OG5_126793_0 - ALL_YMR271C	YMR271C	"URA10 - Minor orotate phosphoribosyltransferase (OPRTase) isozyme that catalyzes the fifth enzymatic step in the de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; major OPRTase encoded by URA5"	1	0.9375	0.916666667	1	0.857142857	0.928571429	1	0.6875
77_OG5_126862_0 - ALL_YGR244C	YGR244C	"LSC2 - Beta subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate"	1	0.9375	0.777777778	1	0.904761905	1	1	0.8125
78_OG5_127151_0 - ALL_YKL151C	YKL151C	YKL151C - Putative protein of unknown function; YKL151C promoter contains STREs (stress response elements) and expression is induced by heat shock or methyl methanesulfonate; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	1	0.9375	0.777777778	1	0.904761905	1	1	0.6875
79_OG5_126927_0 - ALL_YKL148C	YKL148C	"SDH1 - Flavoprotein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain"	1	0.875	0.833333333	1	0.904761905	1	1	0.625
80_OG5_126927_0 - ALL_YJL045W	YJL045W	"YJL045W - Minor succinate dehydrogenase isozyme; homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner"	1	0.875	0.833333333	1	0.904761905	1	1	0.625
81_OG5_127011_0 - ALL_YNL220W	YNL220W	"ADE12 - Adenylosuccinate synthase, catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence"	1	0.8125	0.888888889	1	0.904761905	1	1	0.625
82_OG5_126673_0 - ALL_YFR006W	YFR006W	YFR006W - Putative X-Pro aminopeptidase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YFR006W is not an essential gene	1	0.875	0.777777778	1	0.952380952	1	1	0.5625
83_OG5_126673_0 - ALL_YER078C	YER078C	"ICP55 - Mitochondrial aminopeptidase; cleaves the N termini of at least 38 imported proteins after cleavage by the mitochondrial processing peptidase (MPP), thereby increasing their stability; member of the aminopeptidase P family"	1	0.875	0.777777778	1	0.952380952	1	1	0.5625
84_OG5_126626_0 - ALL_YGL062W	YGL062W	"PYC1 - Pyruvate carboxylase isoform, cytoplasmic enzyme that converts pyruvate to oxaloacetate; highly similar to isoform Pyc2p but differentially regulated; mutations in the human homolog are associated with lactic acidosis"	1	0.6875	1	1	0.904761905	1	1	0.5
85_OG5_126626_0 - ALL_YBR208C	YBR208C	"DUR1,2 - Urea amidolyase, contains both urea carboxylase and allophanate hydrolase activities, degrades urea to CO2 and NH3; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation"	1	0.6875	1	1	0.904761905	1	1	0.5
86_OG5_126626_0 - ALL_YBR218C	YBR218C	"PYC2 - Pyruvate carboxylase isoform, cytoplasmic enzyme that converts pyruvate to oxaloacetate; highly similar to isoform Pyc1p but differentially regulated; mutations in the human homolog are associated with lactic acidosis"	1	0.6875	1	1	0.904761905	1	1	0.5
87_OG5_126796_0 - ALL_YNL061W	YNL061W	"NOP2 - Probable RNA m(5)C methyltransferase, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; localized to the nucleolus; constituent of 66S pre-ribosomal particles"	1	0.8125	0.777777778	1	1	1	1	1
88_OG5_127152_0 - ALL_YMR217W	YMR217W	"GUA1 - GMP synthase; highly conserved enzyme that catalyzes the second step in the biosynthesis of GMP from inosine 5'-phosphate (IMP); transcription is not subject to regulation by guanine but is negatively regulated by nutrient starvation; reduction-of-function mutation gua1-G388D causes changes in cellular guanine nucleotide pools, defects in general protein synthesis, and impaired translation of GCN4 mRNA"	1	0.8125	0.916666667	1	0.857142857	1	1	0.75
89_OG5_126613_0 - ALL_YCR083W	YCR083W	"TRX3 - Mitochondrial thioredoxin, highly conserved oxidoreductase required to maintain the redox homeostasis of the cell, forms the mitochondrial thioredoxin system with Trr2p, redox state is maintained by both Trr2p and Glr1p"	1	0.6875	0.944444444	1	0.952380952	1	1	0.8125
90_OG5_126613_0 - ALL_YGR209C	YGR209C	"TRX2 - Cytoplasmic thioredoxin isoenzyme of the thioredoxin system which protects cells against oxidative and reductive stress, forms LMA1 complex with Pbi2p, acts as a cofactor for Tsa1p, required for ER-Golgi transport and vacuole inheritance"	1	0.6875	0.944444444	1	0.952380952	1	1	0.8125
91_OG5_126613_0 - ALL_YLR043C	YLR043C	"TRX1 - Cytoplasmic thioredoxin isoenzyme of the thioredoxin system which protects cells against oxidative and reductive stress, forms LMA1 complex with Pbi2p, acts as a cofactor for Tsa1p, required for ER-Golgi transport and vacuole inheritance"	1	0.6875	0.944444444	1	0.952380952	1	1	0.8125
92_OG5_126937_0 - ALL_YBR003W	YBR003W	"COQ1 - Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis"	1	0.875	0.861111111	1	0.904761905	0.928571429	1	0.6875
93_OG5_126835_0 - ALL_YJL130C	YJL130C	"URA2 - Bifunctional carbamoylphosphate synthetase (CPSase)-aspartate transcarbamylase (ATCase), catalyzes the first two enzymatic steps in the de novo biosynthesis of pyrimidines; both activities are subject to feedback inhibition by UTP"	1	0.8125	0.888888889	1	0.857142857	1	1	0.625
94_OG5_126835_0 - ALL_YJR109C	YJR109C	"CPA2 - Large subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor"	1	0.8125	0.888888889	1	0.857142857	1	1	0.625
95_OG5_127106_0 - ALL_YOR142W	YOR142W	"LSC1 - Alpha subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate; phosphorylated"	1	0.9375	0.777777778	1	0.904761905	0.928571429	1	0.625
96_OG5_126966_0 - ALL_YHR111W	YHR111W	UBA4 - Protein that activates Urm1p before its conjugation to proteins (urmylation); also acts in thiolation of the wobble base of cytoplasmic tRNAs by adenylating and then thiolating Urm1p; receives sulfur from Tum1p	1	0.8125	0.777777778	1	0.952380952	1	1	1
97_OG5_126893_0 - ALL_YLL041C	YLL041C	"SDH2 - Iron-sulfur protein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain"	1	0.875	0.75	1	0.904761905	1	1	0.6875
98_OG5_126855_0 - ALL_YDR270W	YDR270W	"CCC2 - Cu(+2)-transporting P-type ATPase, required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases"	1	0.75	0.861111111	1	0.904761905	1	1	0.5625
99_OG5_126651_0 - ALL_YLR351C	YLR351C	"NIT3 - Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member"	1	0.75	0.777777778	1	0.952380952	1	1	0.5
100_OG5_126651_0 - ALL_YJL126W	YJL126W	"NIT2 - Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member"	1	0.75	0.777777778	1	0.952380952	1	1	0.5
101_OG5_126858_0 - ALL_YDL141W	YDL141W	"BPL1 - Biotin:apoprotein ligase, covalently modifies proteins with the addition of biotin, required for acetyl-CoA carboxylase (Acc1p) holoenzyme formation"	1	0.6875	1	1	0.857142857	0.928571429	1	0.4375
102_OG5_127040_0 - ALL_YKL088W	YKL088W	"CAB3 - Subunit of a phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis; null mutant lethality is complemented by E. coli coaBC"	1	0.875	0.861111111	1	0.904761905	0.928571429	0.9	0.75
103_OG5_126887_0 - ALL_YLR432W	YLR432W	"IMD3 - Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed"	1	0.625	0.916666667	1	0.904761905	1	1	0.6875
104_OG5_126887_0 - ALL_YML056C	YML056C	"IMD4 - Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed"	1	0.625	0.916666667	1	0.904761905	1	1	0.6875
105_OG5_126887_0 - ALL_YHR216W	YHR216W	"IMD2 - Inosine monophosphate dehydrogenase, catalyzes the rate-limiting step in GTP biosynthesis, expression is induced by mycophenolic acid resulting in resistance to the drug, expression is repressed by nutrient limitatio"	1	0.625	0.916666667	1	0.904761905	1	1	0.6875
106_OG5_127041_0 - ALL_YEL041W	YEL041W	YEF1 - ATP-NADH kinase; phosphorylates both NAD and NADH; homooctameric structure consisting of 60-kDa subunits; sequence similarity to Utr1p and Pos5p; overexpression complements certain pos5 phenotypes	1	0.875	0.805555556	1	0.761904762	1	1	0.625
107_OG5_127041_0 - ALL_YJR049C	YJR049C	UTR1 - ATP-NADH kinase; phosphorylates both NAD and NADH; active as a hexamer; enhances the activity of ferric reductase (Fre1p)	1	0.875	0.805555556	1	0.761904762	1	1	0.625
108_OG5_126839_0 - ALL_YIL066C	YIL066C	"RNR3 - Minor isoform of the large subunit of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits"	1	0.625	0.972222222	1	0.904761905	0.928571429	1	0.875
109_OG5_126839_0 - ALL_YER070W	YER070W	"RNR1 - Major isoform of the large subunit of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits"	1	0.625	0.972222222	1	0.904761905	0.928571429	1	0.875
110_OG5_127466_0 - ALL_YMR293C	YMR293C	HER2 - Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; required for remodeling of ER caused by Hmg2p overexpression; similar to bacterial GatA glutamyl-tRNA amidotransferase	1	0.6875	0.833333333	1	0.904761905	1	1	0.3125
111_OG5_126685_0 - ALL_YOR347C	YOR347C	"PYK2 - Pyruvate kinase that appears to be modulated by phosphorylation; PYK2 transcription is repressed by glucose, and Pyk2p may be active under low glycolytic flux"	1	0.6875	0.777777778	1	0.952380952	1	1	0.875
112_OG5_126685_0 - ALL_YAL038W	YAL038W	"CDC19 - Pyruvate kinase, functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration"	1	0.6875	0.777777778	1	0.952380952	1	1	0.875
113_OG5_127486_0 - ALL_YGL040C	YGL040C	"HEM2 - Aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus"	1	0.8125	0.888888889	1	0.714285714	1	1	0.375
114_OG5_126662_0 - ALL_YGR155W	YGR155W	"CYS4 - Cystathionine beta-synthase, catalyzes synthesis of cystathionine from serine and homocysteine, the first committed step in cysteine biosynthesis; responsible for hydrogen sulfide generation; mutations in human ortholog cause homocystinuria"	1	0.75	0.833333333	1	0.952380952	0.928571429	0.95	0.5
115_OG5_126794_0 - ALL_YDL125C	YDL125C	"HNT1 - Adenosine 5'-monophosphoramidase; interacts physically and genetically with Kin28p, a CDK and TFIIK subunit, and genetically with CAK1; member of the histidine triad (HIT) superfamily of nucleotide-binding proteins and similar to Hint"	1	0.6875	0.944444444	1	0.952380952	0.928571429	0.9	0.9375
116_OG5_126894_0 - ALL_YGL234W	YGL234W	"ADE5,7 - Bifunctional enzyme of the 'de novo' purine nucleotide biosynthetic pathway, contains aminoimidazole ribotide synthetase and glycinamide ribotide synthetase activities"	1	0.75	0.888888889	1	0.761904762	1	1	0.0625
117_OG5_127006_0 - ALL_YER081W	YER081W	"SER3 - 3-phosphoglycerate dehydrogenase, catalyzes the first step in serine and glycine biosynthesis; isozyme of Ser33p"	1	0.875	0.75	1	0.904761905	0.857142857	1	0.3125
118_OG5_127006_0 - ALL_YIL074C	YIL074C	"SER33 - 3-phosphoglycerate dehydrogenase, catalyzes the first step in serine and glycine biosynthesis; isozyme of Ser3p"	1	0.875	0.75	1	0.904761905	0.857142857	1	0.3125
119_OG5_127414_0 - ALL_YOR095C	YOR095C	"RKI1 - Ribose-5-phosphate ketol-isomerase, catalyzes the interconversion of ribose 5-phosphate and ribulose 5-phosphate in the pentose phosphate pathway; participates in pyridoxine biosynthesis"	1	0.9375	0.583333333	1	0.857142857	1	1	0.5
120_OG5_127706_0 - ALL_YMR300C	YMR300C	"ADE4 - Phosphoribosylpyrophosphate amidotransferase (PRPPAT; amidophosphoribosyltransferase), catalyzes first step of the 'de novo' purine nucleotide biosynthetic pathway"	1	0.75	0.888888889	1	0.80952381	0.928571429	1	0.0625
121_OG5_126786_0 - ALL_YFL001W	YFL001W	"DEG1 - tRNA:pseudouridine synthase, introduces pseudouridines at position 38 or 39 in tRNA, important for maintenance of translation efficiency and normal cell growth, localizes to both the nucleus and cytoplasm; non-essential for viability"	1	0.5	0.972222222	1	0.952380952	1	0.95	0.875
122_OG5_127395_0 - ALL_YDL205C	YDL205C	"HEM3 - Porphobilinogen deaminase, catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in heme biosynthesis; localizes to the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p, but not by levels of heme"	1	0.8125	0.888888889	1	0.666666667	1	1	0.3125
123_OG5_126801_0 - ALL_YER023W	YER023W	"PRO3 - Delta 1-pyrroline-5-carboxylate reductase, catalyzes the last step in proline biosynthesis"	1	0.5625	0.888888889	1	0.904761905	1	1	0.6875
124_OG5_126720_0 - ALL_YPR074C	YPR074C	"TKL1 - Transketolase, similar to Tkl2p; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids"	1	0.5	0.944444444	1	0.904761905	1	1	0.6875
125_OG5_126720_0 - ALL_YBR117C	YBR117C	"TKL2 - Transketolase, similar to Tkl1p; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids"	1	0.5	0.944444444	1	0.904761905	1	1	0.6875
126_OG5_126624_0 - ALL_YNR012W	YNR012W	"URK1 - Uridine/cytidine kinase, component of the pyrimidine ribonucleotide salvage pathway that converts uridine into UMP and cytidine into CMP; involved in the pyrimidine deoxyribonucleotide salvage pathway, converting deoxycytidine into dCMP"	1	0.5625	0.833333333	1	0.952380952	1	1	0.5625
127_OG5_126624_0 - ALL_YHR128W	YHR128W	"FUR1 - Uracil phosphoribosyltransferase, synthesizes UMP from uracil; involved in the pyrimidine salvage pathway"	1	0.5625	0.833333333	1	0.952380952	1	1	0.5625
128_OG5_126731_0 - ALL_YHR208W	YHR208W	"BAT1 - Mitochondrial branched-chain amino acid (BCAA) aminotransferase, preferentially involved in BCAA biosynthesis; homolog of murine ECA39; highly expressed during logarithmic phase and repressed during stationary phase"	1	0.5	0.888888889	1	0.952380952	1	1	0.4375
129_OG5_126731_0 - ALL_YJR148W	YJR148W	"BAT2 - Cytosolic branched-chain amino acid (BCAA) aminotransferase, preferentially involved in BCAA catabolism; homolog of murine ECA39; highly expressed during stationary phase and repressed during logarithmic phase"	1	0.5	0.888888889	1	0.952380952	1	1	0.4375
130_OG5_126956_0 - ALL_YHR013C	YHR013C	"ARD1 - Subunit of N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); acetylates many proteins and thus affects telomeric silencing, cell cycle, heat-shock resistance, mating, and sporulation; human Ard1p levels are elevated in cancer cells"	1	0.8125	0.638888889	1	0.952380952	0.928571429	1	0.875
131_OG5_126816_0 - ALL_YKR079C	YKR079C	TRZ1 - tRNA 3'-end processing endonuclease tRNase Z; also localized to mitochondria and interacts genetically with Rex2 exonuclease; homolog of the human candidate prostate cancer susceptibility gene ELAC2	1	1	0.444444444	1	0.952380952	0.928571429	1	0.8125
132_OG5_127330_0 - ALL_YBL080C	YBL080C	PET112 - Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; mutation is functionally complemented by the bacterial GatB ortholog	1	0.75	0.833333333	1	0.80952381	0.928571429	1	0.5
133_OG5_126750_0 - ALL_YKL184W	YKL184W	"SPE1 - Ornithine decarboxylase, catalyzes the first step in polyamine biosynthesis; degraded in a proteasome-dependent manner in the presence of excess polyamines; deletion decreases lifespan, and increases necrotic cell death and ROS generation"	1	0.5	0.861111111	1	0.952380952	1	1	0.5
134_OG5_127233_0 - ALL_YER043C	YER043C	"SAH1 - S-adenosyl-L-homocysteine hydrolase, catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine (AdoMet) to an acceptor"	1	0.9375	0.416666667	1	0.952380952	1	1	0.75
135_OG5_126676_0 - ALL_YHR008C	YHR008C	"SOD2 - Mitochondrial manganese superoxide dismutase, protects cells against oxygen toxicity; phosphorylated"	1	0.4375	0.916666667	1	0.952380952	1	1	0.9375
136_OG5_126763_0 - ALL_YNL168C	YNL168C	"FMP41 - Putative protein of unknown function; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"	1	0.75	0.638888889	1	0.904761905	1	1	0.25
137_OG5_126775_0 - ALL_YAL012W	YAL012W	"CYS3 - Cystathionine gamma-lyase, catalyzes one of the two reactions involved in the transsulfuration pathway that yields cysteine from homocysteine with the intermediary formation of cystathionine"	1	0.5625	0.75	1	0.952380952	1	1	0.5
138_OG5_126775_0 - ALL_YGL184C	YGL184C	"STR3 - Peroxisomal cystathionine beta-lyase, converts cystathionine into homocysteine; may be redox regulated by Gto1p"	1	0.5625	0.75	1	0.952380952	1	1	0.5
139_OG5_127272_0 - ALL_YBR121C	YBR121C	GRS1 - Cytoplasmic and mitochondrial glycyl-tRNA synthase that ligates glycine to the cognate anticodon bearing tRNA; transcription termination factor that may interact with the 3'-end of pre-mRNA to promote 3'-end formation	1	1	0.305555556	1	0.952380952	1	1	1
140_OG5_127272_0 - ALL_YPR081C	YPR081C	"GRS2 - Protein with sequence similarity to Grs1p, which is a glycyl-tRNA synthetase; cannot substitute for Grs1p; possible pseudogene that is expressed at very low levels"	1	1	0.305555556	1	0.952380952	1	1	1
141_OG5_126899_0 - ALL_YEL020C	YEL020C	YEL020C - Hypothetical protein with low sequence identity to Pdc1p	1	0.6875	0.75	1	0.80952381	1	1	0.125
142_OG5_126899_0 - ALL_YMR108W	YMR108W	"ILV2 - Acetolactate synthase, catalyses the first common step in isoleucine and valine biosynthesis and is the target of several classes of inhibitors, localizes to the mitochondria; expression of the gene is under general amino acid control"	1	0.6875	0.75	1	0.80952381	1	1	0.125
143_OG5_126759_0 - ALL_YER086W	YER086W	"ILV1 - Threonine deaminase, catalyzes the first step in isoleucine biosynthesis; expression is under general amino acid control; ILV1 locus exhibits highly positioned nucleosomes whose organization is independent of known ILV1 regulation"	1	0.625	0.777777778	1	0.904761905	0.928571429	1	0.375
144_OG5_126759_0 - ALL_YKL218C	YKL218C	"SRY1 - 3-hydroxyaspartate dehydratase, deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required in the presence of hydroxyaspartate; highly similar to mouse serine racemase (Srr) but has no serine racemase activity"	1	0.625	0.777777778	1	0.904761905	0.928571429	1	0.375
145_OG5_126968_0 - ALL_YFL018C	YFL018C	"LPD1 - Dihydrolipoamide dehydrogenase, the lipoamide dehydrogenase component (E3) of the pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase multi-enzyme complexes"	1	0.4375	0.888888889	1	0.904761905	1	1	0.625
146_OG5_127862_0 - ALL_YHR018C	YHR018C	"ARG4 - Argininosuccinate lyase, catalyzes the final step in the arginine biosynthesis pathway"	1	0.875	0.777777778	1	0.571428571	1	1	0.0625
147_OG5_126982_0 - ALL_YLR438W	YLR438W	"CAR2 - L-ornithine transaminase (OTAse), catalyzes the second step of arginine degradation, expression is dually-regulated by allophanate induction and a specific arginine induction process; not nitrogen catabolite repression sensitive"	1	0.6875	0.722222222	1	0.80952381	1	1	0.3125
148_OG5_126982_0 - ALL_YOL140W	YOL140W	"ARG8 - Acetylornithine aminotransferase, catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine"	1	0.6875	0.722222222	1	0.80952381	1	1	0.3125
149_OG5_126810_0 - ALL_YDR287W	YDR287W	"INM2 - Inositol monophosphatase, involved in biosynthesis of inositol; enzymatic activity requires magnesium ions and is inhibited by lithium and sodium ions; inm1 inm2 double mutant lacks inositol auxotrophy"	1	0.75	0.861111111	1	0.857142857	1	0.75	0.5
150_OG5_126810_0 - ALL_YHR046C	YHR046C	"INM1 - Inositol monophosphatase, involved in biosynthesis of inositol and in phosphoinositide second messenger signaling; INM1 expression increases in the presence of inositol and decreases upon exposure to antibipolar drugs lithium and valproate"	1	0.75	0.861111111	1	0.857142857	1	0.75	0.5
151_OG5_126952_0 - ALL_YFL016C	YFL016C	MDJ1 - Co-chaperone that stimulates the ATPase activity of the HSP70 protein Ssc1p; involved in protein folding/refolding in the mitochodrial matrix; required for proteolysis of misfolded proteins; member of the HSP40 (DnaJ) family of chaperones	1	0.3125	1	1	0.952380952	1	0.95	0.8125
152_OG5_127725_0 - ALL_YGR061C	YGR061C	"ADE6 - Formylglycinamidine-ribonucleotide (FGAM)-synthetase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway"	1	0.75	0.888888889	1	0.714285714	0.857142857	1	0.0625
153_OG5_126762_0 - ALL_YDR226W	YDR226W	"ADK1 - Adenylate kinase, required for purine metabolism; localized to the cytoplasm and the mitochondria; lacks cleavable signal sequence"	1	0.3125	0.944444444	1	0.952380952	1	1	0.875
154_OG5_127234_0 - ALL_YGR195W	YGR195W	SKI6 - Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp41p (EXOSC4)	1	0.75	0.694444444	1	0.952380952	0.857142857	0.95	0.9375
155_OG5_126959_0 - ALL_YCL017C	YCL017C	NFS1 - Cysteine desulfurase involved in iron-sulfur cluster (Fe/S) biogenesis and in thio-modification of mitochondrial and cytoplasmic tRNAs; essential protein located predominantly in mitochondria	1	0.25	1	1	0.952380952	1	1	1
156_OG5_127061_0 - ALL_YBR127C	YBR127C	"VMA2 - Subunit B of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; contains nucleotide binding sites; also detected in the cytoplasm"	1	1	0.25	1	0.952380952	1	1	0.9375
157_OG5_127401_0 - ALL_YPL172C	YPL172C	"COX10 - Heme A:farnesyltransferase, catalyzes the first step in the conversion of protoheme to the heme A prosthetic group required for cytochrome c oxidase activity; human ortholog is associated with mitochondrial disorders"	1	0.625	0.666666667	1	0.904761905	1	1	0.625
158_OG5_127229_0 - ALL_YCR036W	YCR036W	RBK1 - Putative ribokinase	1	0.6875	0.555555556	1	0.952380952	1	1	0.5625
159_OG5_126632_0 - ALL_YOL060C	YOL060C	"MAM3 - Protein required for normal mitochondrial morphology, has similarity to hemolysins"	1	0.3125	0.972222222	1	0.904761905	1	1	0.8125
160_OG5_126746_0 - ALL_YHL032C	YHL032C	"GUT1 - Glycerol kinase, converts glycerol to glycerol-3-phosphate; glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p; derepression of expression on non-fermentable carbon sources is mediated by Opi1p and Rsf1p"	1	0.5	0.777777778	1	0.952380952	1	0.95	0.6875
161_OG5_127074_0 - ALL_YLR146C	YLR146C	"SPE4 - Spermine synthase, required for the biosynthesis of spermine and also involved in biosynthesis of pantothenic acid"	1	0.8125	0.527777778	1	0.904761905	0.928571429	1	0.3125
162_OG5_127074_0 - ALL_YPR069C	YPR069C	"SPE3 - Spermidine synthase, involved in biosynthesis of spermidine and also in biosynthesis of pantothenic acid; spermidine is required for growth of wild-type cells"	1	0.8125	0.527777778	1	0.904761905	0.928571429	1	0.3125
163_OG5_126744_0 - ALL_YLR369W	YLR369W	"SSQ1 - Mitochondrial hsp70-type molecular chaperone, required for assembly of iron/sulfur clusters into proteins at a step after cluster synthesis, and for maturation of Yfh1p, which is a homolog of human frataxin implicated in Friedreich's ataxia"	1	0.3125	1	1	0.857142857	1	1	0.9375
164_OG5_126744_0 - ALL_YEL030W	YEL030W	"ECM10 - Heat shock protein of the Hsp70 family, localized in mitochondrial nucleoids, plays a role in protein translocation, interacts with Mge1p in an ATP-dependent manner; overexpression induces extensive mitochondrial DNA aggregations"	1	0.3125	1	1	0.857142857	1	1	0.9375
165_OG5_126744_0 - ALL_YJR045C	YJR045C	"SSC1 - Hsp70 family ATPase, constituent of the import motor component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); involved in protein translocation and folding; subunit of SceI endonuclease"	1	0.3125	1	1	0.857142857	1	1	0.9375
166_OG5_126870_0 - ALL_YOR136W	YOR136W	"IDH2 - Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase, which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle; phosphorylated"	1	0.8125	0.694444444	0.75	0.904761905	1	1	0.125
167_OG5_126870_0 - ALL_YIL094C	YIL094C	"LYS12 - Homo-isocitrate dehydrogenase, an NAD-linked mitochondrial enzyme required for the fourth step in the biosynthesis of lysine, in which homo-isocitrate is oxidatively decarboxylated to alpha-ketoadipate"	1	0.8125	0.694444444	0.75	0.904761905	1	1	0.125
168_OG5_126847_0 - ALL_YER042W	YER042W	"MXR1 - Methionine-S-sulfoxide reductase, involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR2; involved in the regulation of lifespan"	1	0.4375	0.805555556	1	0.904761905	1	1	0.5
169_OG5_126978_0 - ALL_YOR232W	YOR232W	"MGE1 - Mitochondrial matrix cochaperone, acts as a nucleotide release factor for Ssc1p in protein translocation and folding; also acts as cochaperone for Ssq1p in folding of Fe-S cluster proteins; homolog of E. coli GrpE"	1	0.3125	1	1	0.904761905	0.928571429	1	0.8125
170_OG5_127707_0 - ALL_YOL058W	YOL058W	"ARG1 - Arginosuccinate synthetase, catalyzes the formation of L-argininosuccinate from citrulline and L-aspartate in the arginine biosynthesis pathway; potential Cdc28p substrate"	1	0.875	0.777777778	1	0.523809524	1	0.95	0.125
171_OG5_126768_0 - ALL_YBL019W	YBL019W	APN2 - Class II abasic (AP) endonuclease involved in repair of DNA damage; homolog of human HAP1 and E. coli exoIII	1	0.4375	0.805555556	1	0.952380952	0.928571429	1	0.75
172_OG5_127045_0 - ALL_YNL290W	YNL290W	"RFC3 - Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon"	1	0.4375	0.972222222	1	0.857142857	0.857142857	1	0.9375
173_OG5_126680_0 - ALL_YAL054C	YAL054C	"ACS1 - Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetylation; expressed during growth on nonfermentable carbon sources and under aerobic conditions"	1	0.625	0.583333333	1	0.904761905	1	1	0.875
174_OG5_126680_0 - ALL_YLR153C	YLR153C	"ACS2 - Acetyl-coA synthetase isoform which, along with Acs1p, is the nuclear source of acetyl-coA for histone acetylation; mutants affect global transcription; required for growth on glucose; expressed under anaerobic conditions"	1	0.625	0.583333333	1	0.904761905	1	1	0.875
175_OG5_127211_0 - ALL_YML110C	YML110C	"COQ5 - 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase, involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes"	1	0.4375	0.888888889	1	0.857142857	0.928571429	1	0.6875
176_OG5_127103_0 - ALL_YNL185C	YNL185C	MRPL19 - Mitochondrial ribosomal protein of the large subunit	1	0.4375	1	1	0.80952381	0.857142857	1	0.6875
177_OG5_127105_0 - ALL_YPL175W	YPL175W	"SPT14 - UDP-GlcNAc-binding and catalytic subunit of the enzyme that mediates the first step in glycosylphosphatidylinositol (GPI) biosynthesis, mutations cause defects in transcription and in biogenesis of cell wall proteins"	1	0.6875	0.583333333	0.875	0.952380952	1	1	0.875
178_OG5_126691_0 - ALL_YLR304C	YLR304C	"ACO1 - Aconitase, required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; phosphorylated; component of the mitochondrial nucleoid; mutation leads to glutamate auxotrophy"	1	0.5	0.805555556	0.875	0.904761905	1	1	0.6875
179_OG5_126691_0 - ALL_YJL200C	YJL200C	"ACO2 - Putative mitochondrial aconitase isozyme; similarity to Aco1p, an aconitase required for the TCA cycle; expression induced during growth on glucose, by amino acid starvation via Gcn4p, and repressed on ethanol"	1	0.5	0.805555556	0.875	0.904761905	1	1	0.6875
180_OG5_127079_0 - ALL_YPR183W	YPR183W	"DPM1 - Dolichol phosphate mannose (Dol-P-Man) synthase of the ER membrane, catalyzes the formation of Dol-P-Man from Dol-P and GDP-Man; required for glycosyl phosphatidylinositol membrane anchoring, O mannosylation, and protein glycosylation"	1	0.5625	0.638888889	1	0.952380952	0.928571429	1	0.9375
181_OG5_126671_0 - ALL_YGR204W	YGR204W	"ADE3 - Cytoplasmic trifunctional enzyme C1-tetrahydrofolate synthase, involved in single carbon metabolism and required for biosynthesis of purines, thymidylate, methionine, and histidine; null mutation causes auxotrophy for adenine and histidine"	1	0.25	0.972222222	1	0.857142857	1	1	0.3125
182_OG5_126671_0 - ALL_YBR084W	YBR084W	"MIS1 - Mitochondrial C1-tetrahydrofolate synthase, involved in interconversion between different oxidation states of tetrahydrofolate (THF); provides activities of formyl-THF synthetase, methenyl-THF cyclohydrolase, and methylene-THF dehydrogenase"	1	0.25	0.972222222	1	0.857142857	1	1	0.3125
183_OG5_126583_0 - ALL_YDR368W	YDR368W	"YPR1 - NADPH-dependent aldo-keto reductase, reduces multiple substrates including 2-methylbutyraldehyde and D,L-glyceraldehyde, expression is induced by osmotic and oxidative stress; functionally redundant with other aldo-keto reductases"	1	0.625	0.5	1	0.952380952	1	1	0.625
184_OG5_126583_0 - ALL_YHR104W	YHR104W	"GRE3 - Aldose reductase involved in methylglyoxal, d-xylose, arabinose, and galactose metabolism; stress induced (osmotic, ionic, oxidative, heat shock, starvation and heavy metals); regulated by the HOG pathway"	1	0.625	0.5	1	0.952380952	1	1	0.625
185_OG5_126583_0 - ALL_YOR120W	YOR120W	"GCY1 - Putative NADP(+) coupled glycerol dehydrogenase, proposed to be involved in an alternative pathway for glycerol catabolism; also has mRNA binding activity; member of the aldo-keto reductase (AKR) family"	1	0.625	0.5	1	0.952380952	1	1	0.625
186_OG5_126583_0 - ALL_YJR096W	YJR096W	YJR096W - Putative xylose and arabinose reductase; member of the aldo-keto reductase (AKR) family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS	1	0.625	0.5	1	0.952380952	1	1	0.625
187_OG5_127258_0 - ALL_YPL262W	YPL262W	"FUM1 - Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial distribution determined by the N-terminal targeting sequence, protein conformation, and status of glyoxylate shunt; phosphorylated in mitochondria"	1	0.4375	0.805555556	1	0.952380952	0.928571429	0.95	0.125
188_OG5_127285_0 - ALL_YLR277C	YLR277C	"YSH1 - Putative endoribonuclease, subunit of the mRNA cleavage and polyadenylation specificity complex; required for 3' processing, splicing, and transcriptional termination of mRNAs and snoRNAs"	1	0.8125	0.305555556	1	0.952380952	1	1	0.9375
189_OG5_127507_0 - ALL_YGR267C	YGR267C	"FOL2 - GTP-cyclohydrolase I, catalyzes the first step in the folic acid biosynthetic pathway"	1	0.375	0.833333333	1	0.857142857	1	1	0.3125
190_OG5_126980_0 - ALL_YBR196C	YBR196C	"PGI1 - Glycolytic enzyme phosphoglucose isomerase, catalyzes the interconversion of glucose-6-phosphate and fructose-6-phosphate; required for cell cycle progression and completion of the gluconeogenic events of sporulation"	1	0.25	0.861111111	1	0.952380952	1	1	0.875
191_OG5_126837_0 - ALL_YJR040W	YJR040W	"GEF1 - Voltage-gated chloride channel localized to the golgi, the endosomal system, and plasma membrane, and involved in cation homeostasis; highly homologous to vertebrate voltage-gated chloride channels"	1	0.6875	0.555555556	1	0.80952381	1	1	0.3125
192_OG5_126783_0 - ALL_YDR232W	YDR232W	"HEM1 - 5-aminolevulinate synthase, catalyzes the first step in the heme biosynthetic pathway; an N-terminal signal sequence is required for localization to the mitochondrial matrix; expression is regulated by Hap2p-Hap3p"	1	0.3125	0.805555556	1	0.904761905	1	1	0.4375
193_OG5_126585_0 - ALL_YIL149C	YIL149C	"MLP2 - Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved in the Tel1p pathway that controls telomere length"	1	0.625	0.583333333	1	0.904761905	1	0.9	0.8125
194_OG5_126585_0 - ALL_YKR095W	YKR095W	"MLP1 - Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved with Tel1p in telomere length control; involved with Pml1p and Pml39p in nuclear retention of unspliced mRNAs"	1	0.625	0.583333333	1	0.904761905	1	0.9	0.8125
195_OG5_126585_0 - ALL_YDL058W	YDL058W	USO1 - Essential protein involved in the vesicle-mediated ER to Golgi transport step of secretion; binds membranes and functions during vesicle docking to the Golgi; required for assembly of the ER-to-Golgi SNARE complex	1	0.625	0.583333333	1	0.904761905	1	0.9	0.8125
196_OG5_127289_0 - ALL_YKL216W	YKL216W	"URA1 - Dihydroorotate dehydrogenase, catalyzes the fourth enzymatic step in the de novo biosynthesis of pyrimidines, converting dihydroorotic acid into orotic acid"	1	0.4375	0.833333333	0.875	0.857142857	1	1	0.6875
197_OG5_126638_0 - ALL_YMR170C	YMR170C	"ALD2 - Cytoplasmic aldehyde dehydrogenase, involved in ethanol oxidation and beta-alanine biosynthesis; uses NAD+ as the preferred coenzyme; expression is stress induced and glucose repressed; very similar to Ald3p"	1	0.5625	0.555555556	1	0.857142857	1	1	0.3125
198_OG5_126638_0 - ALL_YER073W	YER073W	"ALD5 - Mitochondrial aldehyde dehydrogenase, involved in regulation or biosynthesis of electron transport chain components and acetate formation; activated by K+; utilizes NADP+ as the preferred coenzyme; constitutively expressed"	1	0.5625	0.555555556	1	0.857142857	1	1	0.3125
199_OG5_126638_0 - ALL_YOR374W	YOR374W	"ALD4 - Mitochondrial aldehyde dehydrogenase, required for growth on ethanol and conversion of acetaldehyde to acetate; phosphorylated; activity is K+ dependent; utilizes NADP+ or NAD+ equally as coenzymes; expression is glucose repressed"	1	0.5625	0.555555556	1	0.857142857	1	1	0.3125
200_OG5_126638_0 - ALL_YMR169C	YMR169C	"ALD3 - Cytoplasmic aldehyde dehydrogenase, involved in beta-alanine synthesis; uses NAD+ as the preferred coenzyme; very similar to Ald2p; expression is induced by stress and repressed by glucose"	1	0.5625	0.555555556	1	0.857142857	1	1	0.3125
201_OG5_126857_0 - ALL_YOR375C	YOR375C	"GDH1 - NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh3p; expression regulated by nitrogen and carbon sources"	1	0.75	0.611111111	0.75	0.904761905	1	0.95	0.625
202_OG5_126857_0 - ALL_YAL062W	YAL062W	"GDH3 - NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources"	1	0.75	0.611111111	0.75	0.904761905	1	0.95	0.625
203_OG5_127715_0 - ALL_YJL088W	YJL088W	"ARG3 - Ornithine carbamoyltransferase (carbamoylphosphate:L-ornithine carbamoyltransferase), catalyzes the sixth step in the biosynthesis of the arginine precursor ornithine"	1	0.9375	0.805555556	1	0.285714286	0.928571429	1	0.1875
204_OG5_127035_0 - ALL_YDR321W	YDR321W	"ASP1 - Cytosolic L-asparaginase, involved in asparagine catabolism"	1	1	0.666666667	0.625	0.857142857	0.857142857	0.95	0.4375
205_OG5_127035_0 - ALL_YLR155C	YLR155C	ASP3-1 - Cell-wall L-asparaginase II involved in asparagine catabolism; expression induced during nitrogen starvation; ORF contains a short non-coding RNA that enhances expression of full-length gene; reference strain S288C has four copies of ASP3	1	1	0.666666667	0.625	0.857142857	0.857142857	0.95	0.4375
206_OG5_127035_0 - ALL_YLR157C	YLR157C	ASP3-2 - Cell-wall L-asparaginase II involved in asparagine catabolism; expression induced during nitrogen starvation; ORF contains a short non-coding RNA that enhances expression of full-length gene; reference strain S288C has four copies of ASP3	1	1	0.666666667	0.625	0.857142857	0.857142857	0.95	0.4375
207_OG5_127035_0 - ALL_YLR158C	YLR158C	ASP3-3 - Cell-wall L-asparaginase II involved in asparagine catabolism; expression induced during nitrogen starvation; ORF contains a short non-coding RNA that enhances expression of full-length gene; reference strain S288C has four copies of ASP3	1	1	0.666666667	0.625	0.857142857	0.857142857	0.95	0.4375
208_OG5_127035_0 - ALL_YLR160C	YLR160C	ASP3-4 - Cell-wall L-asparaginase II involved in asparagine catabolism; expression induced during nitrogen starvation; ORF contains a short non-coding RNA that enhances expression of full-length gene; reference strain S288C has four copies of ASP3	1	1	0.666666667	0.625	0.857142857	0.857142857	0.95	0.4375
209_OG5_127020_0 - ALL_YOR226C	YOR226C	"ISU2 - Conserved protein of the mitochondrial matrix, required for synthesis of mitochondrial and cytosolic iron-sulfur proteins, performs a scaffolding function in mitochondria during Fe/S cluster assembly; isu1 isu2 double mutant is inviable"	1	0.375	0.916666667	0.875	0.857142857	0.928571429	1	0.9375
210_OG5_127020_0 - ALL_YPL135W	YPL135W	"ISU1 - Conserved protein of the mitochondrial matrix, performs a scaffolding function during assembly of iron-sulfur clusters, interacts physically and functionally with yeast frataxin (Yfh1p); isu1 isu2 double mutant is inviable"	1	0.375	0.916666667	0.875	0.857142857	0.928571429	1	0.9375
211_OG5_127961_0 - ALL_YMR120C	YMR120C	"ADE17 - Enzyme of 'de novo' purine biosynthesis containing both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities, isozyme of Ade16p; ade16 ade17 mutants require adenine and histidine"	1	0.25	0.888888889	1	0.80952381	1	1	0.0625
212_OG5_127961_0 - ALL_YLR028C	YLR028C	"ADE16 - Enzyme of 'de novo' purine biosynthesis containing both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities, isozyme of Ade17p; ade16 ade17 mutants require adenine and histidine"	1	0.25	0.888888889	1	0.80952381	1	1	0.0625
213_OG5_126609_0 - ALL_YBR222C	YBR222C	"PCS60 - Peroxisomal protein that binds AMP and mRNA, localizes to both the peroxisomal peripheral membrane and matrix, expression is highly inducible by oleic acid, similar to E. coli long chain acyl-CoA synthetase"	1	0.5625	0.722222222	1	0.857142857	1	0.8	0.1875
214_OG5_127109_0 - ALL_YDL055C	YDL055C	"PSA1 - GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase), synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure"	1	0.9375	0.555555556	0.75	0.857142857	0.928571429	0.9	0.9375
215_OG5_127043_0 - ALL_YER057C	YER057C	"HMF1 - Member of the p14.5 protein family with similarity to Mmf1p, functionally complements Mmf1p function when targeted to mitochondria; heat shock inducible; high-dosage growth inhibitor; forms a homotrimer in vitro"	1	0.4375	0.75	1	0.80952381	0.928571429	1	0.1875
216_OG5_127043_0 - ALL_YIL051C	YIL051C	MMF1 - Mitochondrial protein required for transamination of isoleucine but not of valine or leucine; may regulate specificity of branched-chain transaminases Bat1p and Bat2p; interacts genetically with mitochondrial ribosomal protein genes	1	0.4375	0.75	1	0.80952381	0.928571429	1	0.1875
217_OG5_127565_0 - ALL_YPR118W	YPR118W	MRI1 - 5'-methylthioribose-1-phosphate isomerase; catalyzes the isomerization of 5-methylthioribose-1-phosphate to 5-methylthioribulose-1-phosphate in the methionine salvage pathway	1	0.875	0.333333333	1	0.857142857	0.857142857	1	0.25
218_OG5_127429_0 - ALL_YDL102W	YDL102W	"POL3 - Catalytic subunit of DNA polymerase delta; required for chromosomal DNA replication during mitosis and meiosis, intragenic recombination, repair of double strand DNA breaks, and DNA replication during nucleotide excision repair (NER)"	1	0.9375	0.222222222	1	0.904761905	0.857142857	1	1
219_OG5_127169_0 - ALL_YAL044C	YAL044C	"GCV3 - H subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; also required for all protein lipoylation; expression is regulated by levels of 5,10-methylene-THF"	1	0.4375	0.75	1	0.857142857	0.857142857	1	0.5625
220_OG5_128110_0 - ALL_YGR208W	YGR208W	"SER2 - Phosphoserine phosphatase of the phosphoglycerate pathway, involved in serine and glycine biosynthesis, expression is regulated by the available nitrogen source"	1	0.6875	0.527777778	1	0.857142857	1	0.8	0.25
221_OG5_127093_0 - ALL_YDL174C	YDL174C	"DLD1 - D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane"	1	0.6875	0.694444444	1	0.523809524	1	0.95	0.125
222_OG5_127332_0 - ALL_YNR041C	YNR041C	"COQ2 - Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis"	1	0.4375	0.666666667	0.875	0.857142857	1	1	0.6875
223_OG5_127381_0 - ALL_YLR245C	YLR245C	"CDD1 - Cytidine deaminase; catalyzes the modification of cytidine to uridine in vitro but native RNA substrates have not been identified, localizes to both the nucleus and cytoplasm"	1	0.4375	0.611111111	1	0.904761905	0.928571429	0.95	0.4375
224_OG5_127626_0 - ALL_YGR264C	YGR264C	"MES1 - Methionyl-tRNA synthetase, forms a complex with glutamyl-tRNA synthetase (Gus1p) and Arc1p, which increases the catalytic efficiency of both tRNA synthetases; also has a role in nuclear export of tRNAs"	1	0.9375	0.5	0.75	0.857142857	0.785714286	1	0.25
225_OG5_127238_0 - ALL_YLR354C	YLR354C	"TAL1 - Transaldolase, enzyme in the non-oxidative pentose phosphate pathway; converts sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate to erythrose 4-phosphate and fructose 6-phosphate"	1	0.25	0.722222222	1	0.857142857	1	1	0.5
226_OG5_127238_0 - ALL_YGR043C	YGR043C	NQM1 - Transaldolase of unknown function; transcription is repressed by Mot1p and induced by alpha-factor and during diauxic shift	1	0.25	0.722222222	1	0.857142857	1	1	0.5
227_OG5_127334_0 - ALL_YMR189W	YMR189W	"GCV2 - P subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of 5,10-methylene-THF in the cytoplasm"	1	0.375	0.694444444	1	0.80952381	1	0.95	0.3125
228_OG5_127215_0 - ALL_YIL155C	YIL155C	"GUT2 - Mitochondrial glycerol-3-phosphate dehydrogenase; expression is repressed by both glucose and cAMP and derepressed by non-fermentable carbon sources in a Snf1p, Rsf1p, Hap2/3/4/5 complex dependent manner"	1	0.375	0.638888889	1	0.80952381	1	1	0.6875
229_OG5_127412_0 - ALL_YDR019C	YDR019C	"GCV1 - T subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of levels of 5,10-methylene-THF in the cytoplasm"	1	0.5	0.694444444	1	0.80952381	0.857142857	0.95	0.5
230_OG5_127282_0 - ALL_YFL030W	YFL030W	"AGX1 - Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases"	1	0.875	0.5	0.875	0.619047619	1	0.9	0.375
231_OG5_126579_0 - ALL_YMR317W	YMR317W	YMR317W - Putative protein of unknown function with some similarity to sialidase from Trypanosoma; YMR317W is not an essential gene	1	0.3125	0.5	1	0.952380952	1	1	0.75
232_OG5_126579_0 - ALL_YIL169C	YIL169C	"YIL169C - Putative protein of unknown function; serine/threonine rich and highly similar to YOL155C, a putative glucan alpha-1,4-glucosidase; transcript is induced in both high and low pH environments; YIL169C is a non-essential gene"	1	0.3125	0.5	1	0.952380952	1	1	0.75
233_OG5_126579_0 - ALL_YCR089W	YCR089W	"FIG2 - Cell wall adhesin, expressed specifically during mating; may be involved in maintenance of cell wall integrity during mating"	1	0.3125	0.5	1	0.952380952	1	1	0.75
234_OG5_126579_0 - ALL_YGR014W	YGR014W	MSB2 - Mucin family member involved in the Cdc42p- and MAP kinase-dependent filamentous growth signaling pathway; also functions as an osmosensor in parallel to the Sho1p-mediated pathway; potential Cdc28p substrate	1	0.3125	0.5	1	0.952380952	1	1	0.75
235_OG5_126579_0 - ALL_YIR019C	YIR019C	"MUC1 - GPI-anchored cell surface glycoprotein (flocculin) required for pseudohyphal formation, invasive growth, flocculation, and biofilms; transcriptionally regulated by the MAPK pathway (via Ste12p and Tec1p) and the cAMP pathway (via Flo8p)"	1	0.3125	0.5	1	0.952380952	1	1	0.75
236_OG5_126579_0 - ALL_YDL039C	YDL039C	"PRM7 - Pheromone-regulated protein, predicted to have one transmembrane segment; promoter contains Gcn4p binding elements"	1	0.3125	0.5	1	0.952380952	1	1	0.75
237_OG5_126579_0 - ALL_YAR050W	YAR050W	"FLO1 - Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p"	1	0.3125	0.5	1	0.952380952	1	1	0.75
238_OG5_126579_0 - ALL_YOL155C	YOL155C	HPF1 - Haze-protective mannoprotein that reduces the particle size of aggregated proteins in white wines	1	0.3125	0.5	1	0.952380952	1	1	0.75
239_OG5_126579_0 - ALL_YAL063C	YAL063C	"FLO9 - Lectin-like protein with similarity to Flo1p, thought to be expressed and involved in flocculation"	1	0.3125	0.5	1	0.952380952	1	1	0.75
240_OG5_126579_0 - ALL_YDR420W	YDR420W	"HKR1 - Mucin family member that functions as an osmosensor in the Sho1p-mediated HOG pathway with Msb2p; proposed to be a negative regulator of filamentous growth; mutant displays defects in beta-1,3 glucan synthesis and bud site selection"	1	0.3125	0.5	1	0.952380952	1	1	0.75
241_OG5_126579_0 - ALL_YHR211W	YHR211W	"FLO5 - Lectin-like cell wall protein (flocculin) involved in flocculation, binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin resistant but heat labile; similar to Flo1p"	1	0.3125	0.5	1	0.952380952	1	1	0.75
242_OG5_127204_0 - ALL_YGR124W	YGR124W	"ASN2 - Asparagine synthetase, isozyme of Asn1p; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway"	1	0.5625	0.5	1	0.761904762	0.928571429	1	0.25
243_OG5_127204_0 - ALL_YPR145W	YPR145W	"ASN1 - Asparagine synthetase, isozyme of Asn2p; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway"	1	0.5625	0.5	1	0.761904762	0.928571429	1	0.25
244_OG5_127379_0 - ALL_YML022W	YML022W	"APT1 - Adenine phosphoribosyltransferase, catalyzes the formation of AMP from adenine and 5-phosphoribosylpyrophosphate; involved in the salvage pathway of purine nucleotide biosynthesis"	1	0.375	0.722222222	1	0.857142857	0.785714286	1	0.375
245_OG5_126733_0 - ALL_YMR301C	YMR301C	"ATM1 - Mitochondrial inner membrane ATP-binding cassette (ABC) transporter, exports mitochondrially synthesized precursors of iron-sulfur (Fe/S) clusters to the cytosol"	1	0.3125	0.583333333	1	0.904761905	0.928571429	1	0.875
246_OG5_126871_0 - ALL_YGL136C	YGL136C	"MRM2 - Mitochondrial 2' O-ribose methyltransferase, required for methylation of U(2791) in 21S rRNA; MRM2 deletion confers thermosensitive respiration and loss of mitochondrial DNA; has similarity to Spb1p and Trm7p, and to E. coli FtsJ/RrmJ"	1	0.5	0.277777778	1	1	1	0.95	0.9375
247_OG5_126871_0 - ALL_YCL054W	YCL054W	"SPB1 - AdoMet-dependent methyltransferase involved in rRNA processing and 60S ribosomal subunit maturation; methylates G2922 in the tRNA docking site of the large subunit rRNA and in the absence of snR52, U2921; suppressor of PAB1 mutants"	1	0.5	0.277777778	1	1	1	0.95	0.9375
248_OG5_126757_0 - ALL_YPL028W	YPL028W	"ERG10 - Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase), cytosolic enzyme that transfers an acetyl group from one acetyl-CoA molecule to another, forming acetoacetyl-CoA; involved in the first step in mevalonate biosynthesis"	1	0.5	0.555555556	0.75	0.904761905	1	1	0.5625
249_OG5_126756_0 - ALL_YCR024C	YCR024C	SLM5 - Mitochondrial asparaginyl-tRNA synthetase	1	0.3125	0.444444444	1	0.952380952	1	1	1
250_OG5_126756_0 - ALL_YHR019C	YHR019C	"DED81 - Cytosolic asparaginyl-tRNA synthetase, required for protein synthesis, catalyzes the specific attachment of asparagine to its cognate tRNA"	1	0.3125	0.444444444	1	0.952380952	1	1	1
251_OG5_126853_0 - ALL_YBR019C	YBR019C	"GAL10 - UDP-glucose-4-epimerase, catalyzes the interconversion of UDP-galactose and UDP-D-glucose in galactose metabolism; also catalyzes the conversion of alpha-D-glucose or alpha-D-galactose to their beta-anomers"	1	0.25	0.666666667	1	0.952380952	0.928571429	0.9	0.625
252_OG5_127742_0 - ALL_YGR101W	YGR101W	PCP1 - Mitochondrial serine protease required for the processing of various mitochondrial proteins and maintenance of mitochondrial DNA and morphology; belongs to the rhomboid-GlpG superfamily of intramembrane peptidases	1	0.5625	0.333333333	0.875	0.904761905	1	1	0.1875
253_OG5_126648_0 - ALL_YPL088W	YPL088W	YPL088W - Putative aryl alcohol dehydrogenase; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance	1	0.625	0.527777778	1	0.571428571	1	0.95	0.5
254_OG5_127049_0 - ALL_YDL236W	YDL236W	PHO13 - Alkaline phosphatase specific for p-nitrophenyl phosphate; also has protein phosphatase activity	1	0.5	0.305555556	1	0.857142857	1	1	0.5625
255_OG5_126728_0 - ALL_YBR296C	YBR296C	"PHO89 - Na+/Pi cotransporter, active in early growth phase; similar to phosphate transporters of Neurospora crassa; transcription regulated by inorganic phosphate concentrations and Pho4p"	1	0.5	0.694444444	1	0.714285714	1	0.75	0.625
256_OG5_126787_0 - ALL_YNL274C	YNL274C	"GOR1 - Glyoxylate reductase; null mutation results in increased biomass after diauxic shift; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"	1	0.5625	0.444444444	0.875	0.761904762	1	1	0.125
257_OG5_127281_0 - ALL_YDL238C	YDL238C	"GUD1 - Guanine deaminase, a catabolic enzyme of the guanine salvage pathway producing xanthine and ammonia from guanine; activity is low in exponentially-growing cultures but expression is increased in post-diauxic and stationary-phase cultures"	1	0.8125	0.5	0.75	0.666666667	0.928571429	0.95	0.25
258_OG5_127004_0 - ALL_YBR006W	YBR006W	UGA2 - Succinate semialdehyde dehydrogenase involved in the utilization of gamma-aminobutyrate (GABA) as a nitrogen source; part of the 4-aminobutyrate and glutamate degradation pathways; localized to the cytoplasm	1	0.5	0.527777778	0.75	0.857142857	0.928571429	1	0.4375
259_OG5_127844_0 - ALL_YPR004C	YPR004C	"AIM45 - Putative ortholog of mammalian electron transfer flavoprotein complex subunit ETF-alpha; interacts with frataxin, Yfh1p; null mutant displays elevated frequency of mitochondrial genome loss; may have a role in oxidative stress response"	1	0.4375	0.5	0.75	0.857142857	1	1	0.3125
260_OG5_127708_0 - ALL_YGR207C	YGR207C	CIR1 - Mitochondrial protein that interacts with frataxin (Yfh1p); putative ortholog of mammalian electron transfer flavoprotein complex subunit ETF-beta; may have a role in oxidative stress response	1	0.4375	0.5	0.75	0.904761905	0.928571429	1	0.375
261_OG5_126973_0 - ALL_YLR253W	YLR253W	"YLR253W - Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; transcription is periodic during the metabolic cycle; YLR253W is not an essential gene"	1	0.25	0.361111111	1	0.904761905	1	1	0.75
262_OG5_126880_0 - ALL_YBR229C	YBR229C	"ROT2 - Glucosidase II catalytic subunit required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations"	1	0.3125	0.25	1	0.952380952	1	1	0.5625
263_OG5_127471_0 - ALL_YOR168W	YOR168W	"GLN4 - Glutamine tRNA synthetase, monomeric class I tRNA synthetase that catalyzes the specific glutaminylation of tRNA(Glu); N-terminal domain proposed to be involved in enzyme-tRNA interactions"	1	0.375	0.388888889	1	0.857142857	0.857142857	1	1
264_OG5_127397_0 - ALL_YKL175W	YKL175W	"ZRT3 - Vacuolar membrane zinc transporter, transports zinc from storage in the vacuole to the cytoplasm when needed; transcription is induced under conditions of zinc deficiency"	1	0.3125	0.444444444	1	0.904761905	1	0.8	0.1875
265_OG5_127271_0 - ALL_YKL001C	YKL001C	"MET14 - Adenylylsulfate kinase, required for sulfate assimilation and involved in methionine metabolism"	1	0.3125	0.416666667	0.875	0.857142857	1	1	0.125
266_OG5_126577_0 - ALL_YAL029C	YAL029C	"MYO4 - One of two type V myosin motors (along with MYO2) involved in actin-based transport of cargos; required for mRNA transport, including ASH1 mRNA, and facilitating the growth and movement of ER tubules into the growing bud along with She3p"	1	0.3125	0.222222222	1	0.904761905	1	1	0.9375
267_OG5_126577_0 - ALL_YOR326W	YOR326W	"MYO2 - One of two type V myosin motors (along with MYO4) involved in actin-based transport of cargos; required for the polarized delivery of secretory vesicles, the vacuole, late Golgi elements, peroxisomes, and the mitotic spindle"	1	0.3125	0.222222222	1	0.904761905	1	1	0.9375
268_OG5_126577_0 - ALL_YHR023W	YHR023W	"MYO1 - Type II myosin heavy chain, required for wild-type cytokinesis and cell separation; localizes to the actomyosin ring; binds to myosin light chains Mlc1p and Mlc2p through its IQ1 and IQ2 motifs respectively"	1	0.3125	0.222222222	1	0.904761905	1	1	0.9375
269_OG5_127440_0 - ALL_YLR086W	YLR086W	SMC4 - Subunit of the condensin complex; reorganizes chromosomes during cell division; forms a complex with Smc2p that has ATP-hydrolyzing and DNA-binding activity; required for tRNA gene clustering at the nucleolus; potential Cdc28p substrate	1	0.3125	0.25	1	0.952380952	1	0.9	1
270_OG5_127802_0 - ALL_YIR027C	YIR027C	"DAL1 - Allantoinase, converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression"	1	0.875	0.75	1	0.380952381	0.428571429	0.9	0.1875
271_OG5_127325_0 - ALL_YLR151C	YLR151C	"PCD1 - Peroxisomal nudix pyrophosphatase with specificity for coenzyme A and CoA derivatives, may function to remove potentially toxic oxidized CoA disulfide from peroxisomes to maintain the capacity for beta-oxidation of fatty acids"	1	0.3125	0.5	0.75	0.80952381	0.928571429	1	0.25
272_OG5_126928_0 - ALL_YAL061W	YAL061W	BDH2 - Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3	1	0.4375	0.583333333	0.5	0.761904762	1	1	0.125
273_OG5_126928_0 - ALL_YDL246C	YDL246C	SOR2 - Protein of unknown function; protein sequence is 99% identical to the Sor1p sorbitol dehydrogenase; computational analysis of large-scale protein-protein interaction data also suggests a role in fructose or mannose metabolism	1	0.4375	0.583333333	0.5	0.761904762	1	1	0.125
274_OG5_126928_0 - ALL_YAL060W	YAL060W	"BDH1 - NAD-dependent (R,R)-butanediol dehydrogenase, catalyzes oxidation of (R,R)-2,3-butanediol to (3R)-acetoin, oxidation of meso-butanediol to (3S)-acetoin, and reduction of acetoin; enhances use of 2,3-butanediol as an aerobic carbon source"	1	0.4375	0.583333333	0.5	0.761904762	1	1	0.125
275_OG5_126928_0 - ALL_YLR070C	YLR070C	"XYL2 - Xylitol dehydrogenase, converts xylitol to D-xylulose; expression induced by xylose, even though this pentose sugar is not well utilized by S. cerevisiae; null mutant has cell wall defect"	1	0.4375	0.583333333	0.5	0.761904762	1	1	0.125
276_OG5_126928_0 - ALL_YJR159W	YJR159W	SOR1 - Sorbitol dehydrogenase; expression is induced in the presence of sorbitol or xylose	1	0.4375	0.583333333	0.5	0.761904762	1	1	0.125
277_OG5_126615_0 - ALL_YFL054C	YFL054C	YFL054C - Putative channel-like protein; similar to Fps1p; mediates passive diffusion of glycerol in the presence of ethanol	1	0.3125	0.555555556	0.75	0.80952381	1	0.85	0.5
278_OG5_126615_0 - ALL_YLL043W	YLL043W	"FPS1 - Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress"	1	0.3125	0.555555556	0.75	0.80952381	1	0.85	0.5
279_OG5_127177_0 - ALL_YHR047C	YHR047C	"AAP1 - Arginine/alanine aminopeptidase, overproduction stimulates glycogen accumulation"	1	0.375	0.222222222	0.75	0.952380952	1	0.95	0.5
280_OG5_127177_0 - ALL_YKL157W	YKL157W	APE2 - Aminopeptidase yscII; may have a role in obtaining leucine from dipeptide substrates; sequence coordinates have changed since RT-PCR analysis showed that the adjacent ORF YKL158W comprises the 5' exon of APE2/YKL157W	1	0.375	0.222222222	0.75	0.952380952	1	0.95	0.5
281_OG5_126647_0 - ALL_YDR338C	YDR338C	"YDR338C - Putative protein of unknown function, member of the multi-drug and toxin extrusion (MATE) family of the multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter superfamily"	1	0.3125	0.638888889	1	0.333333333	0.928571429	1	0.3125
282_OG5_126647_0 - ALL_YHR032W	YHR032W	ERC1 - Member of the multi-drug and toxin extrusion (MATE) family of the multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter superfamily; overproduction confers ethionine resistance and accumulation of S-adenosylmethionine	1	0.3125	0.638888889	1	0.333333333	0.928571429	1	0.3125
283_OG5_127905_0 - ALL_YHL018W	YHL018W	YHL018W - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria and is induced in response to the DNA-damaging agent MMS	1	0.3125	0.361111111	1	0.857142857	0.928571429	0.75	0.5
284_OG5_128337_0 - ALL_YOR356W	YOR356W	CIR2 - Putative ortholog of human electron transfer flavoprotein dehydrogenase (ETF-dH); found in a large supramolecular complex with other mitochondrial dehydrogenases; may have a role in oxidative stress response	1	0.25	0.277777778	0.75	0.904761905	1	1	0.375
285_OG5_128545_0 - ALL_YFR047C	YFR047C	"BNA6 - Quinolinate phosphoribosyl transferase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p"	1	0.625	0.75	1	0.285714286	0.714285714	0.8	0.0625
286_OG5_127007_0 - ALL_YER152C	YER152C	YER152C - Protein with 2-aminoadipate transaminase activity; shares amino acid similarity with the aminotransferases Aro8p and Aro9p; YER152C is not an essential gene	1	0.5625	0.555555556	0.375	0.666666667	1	1	0.1875
287_OG5_127007_0 - ALL_YGL202W	YGL202W	"ARO8 - Aromatic aminotransferase I, expression is regulated by general control of amino acid biosynthesis"	1	0.5625	0.555555556	0.375	0.666666667	1	1	0.1875
288_OG5_126778_0 - ALL_YIL124W	YIL124W	"AYR1 - NADPH-dependent 1-acyl dihydroxyacetone phosphate reductase found in lipid particles, ER, and mitochondrial outer membrane; involved in phosphatidic acid biosynthesis; required for spore germination; capable of metabolizing steroid hormones"	1	0.25	0.527777778	1	0.428571429	1	0.95	0.0625
289_OG5_127985_0 - ALL_YDR305C	YDR305C	HNT2 - Dinucleoside triphosphate hydrolase; has similarity to the tumor suppressor FHIT and belongs to the histidine triad (HIT) superfamily of nucleotide-binding proteins	1	0.625	0.277777778	1	0.238095238	1	1	0.6875
290_OG5_127209_0 - ALL_YDR336W	YDR336W	YDR336W - Putative protein of unknown function; sumoylated under stress conditions in a genome wide study; YDR336W is not an essential gene	1	0.25	0.777777778	1	0.380952381	0.928571429	0.8	0.6875
291_OG5_127505_0 - ALL_YBR111C	YBR111C	YSA1 - Nudix hydrolase family member with ADP-ribose pyrophosphatase activity; shown to metabolize O-acetyl-ADP-ribose to AMP and acetylated ribose 5'-phosphate	1	0.5	0.694444444	0.625	0.428571429	0.857142857	1	0.5
292_OG5_127129_0 - ALL_YOR251C	YOR251C	"TUM1 - Rhodanese domain sulfur transferase, accepts persulfite from Nfs1p and transfers it to Uba4p in the pathway for 2-thiolation of the wobble uridine base of tRNAs; also stimulates sulfur transfer by Nfs1p; may be mitochondrially localized"	1	0.375	0.5	0.875	0.476190476	0.928571429	0.95	0.5625
293_OG5_127991_0 - ALL_YML078W	YML078W	"CPR3 - Mitochondrial peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; involved in protein refolding after import into mitochondria"	1	0.25	0.388888889	1	0.761904762	0.928571429	0.75	0.5625
294_OG5_127355_0 - ALL_YDL200C	YDL200C	MGT1 - DNA repair methyltransferase (6-O-methylguanine-DNA methylase) involved in protection against DNA alkylation damage	1	0.8125	0.861111111	0.375	0.476190476	0.785714286	0.7	0.1875
295_OG5_127140_0 - ALL_YGL256W	YGL256W	"ADH4 - Alcohol dehydrogenase isoenzyme type IV, dimeric enzyme demonstrated to be zinc-dependent despite sequence similarity to iron-activated alcohol dehydrogenases; transcription is induced in response to zinc deficiency"	1	0.375	0.583333333	0.625	0.619047619	0.928571429	0.75	0.375
296_OG5_127186_0 - ALL_YOR386W	YOR386W	"PHR1 - DNA photolyase involved in photoreactivation, repairs pyrimidine dimers in the presence of visible light; induced by DNA damage; regulated by transcriptional repressor Rph1p"	1	0.25	0.416666667	1	0.714285714	0.928571429	0.45	0.25
297_OG5_128502_0 - ALL_YGL159W	YGL159W	YGL159W - Putative protein of unknown function; deletion mutant has no detectable phenotype	1	0.5625	0.305555556	0.625	0.523809524	0.928571429	0.8	0.125
298_OG5_128594_0 - ALL_YBR046C	YBR046C	"ZTA1 - NADPH-dependent quinone reductase, GFP-tagged protein localizes to the cytoplasm and nucleus; has similarity to E. coli quinone oxidoreductase and to human zeta-crystallin"	1	0.3125	0.416666667	0.75	0.380952381	0.928571429	0.95	0.125
299_OG5_128333_0 - ALL_YIL160C	YIL160C	"POT1 - 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids"	1	0.25	0.388888889	1	0.238095238	0.857142857	0.95	0.25
300_OG5_128504_0 - ALL_Q0120	Q0120	"BI4 - Mitochondrial mRNA maturase, forms a complex with Nam2p to mediate splicing of the bI4 intron of the COB gene; encoded by both exon and intron sequences of partially processed COB mRNA"	1	0.5	0.527777778	0.625	0.428571429	0.857142857	0.6	0.3125
301_OG5_128504_0 - ALL_Q0105	Q0105	"COB - Cytochrome b, mitochondrially encoded subunit of the ubiquinol-cytochrome c reductase complex which includes Cobp, Rip1p, Cyt1p, Cor1p, Qcr2p, Qcr6p, Qcr7p, Qcr8p, Qcr9p, and Qcr10p"	1	0.5	0.527777778	0.625	0.428571429	0.857142857	0.6	0.3125
302_OG5_128358_0 - ALL_Q0045	Q0045	"COX1 - Subunit I of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; one of three mitochondrially-encoded subunits"	1	0.375	0.638888889	0.5	0.380952381	0.857142857	0.55	0.3125
303_OG5_128358_0 - ALL_Q0070	Q0070	"AI5_ALPHA - Endonuclease I-SceIV, involved in intron mobility; encoded by a mobile group I intron within the mitochondrial COX1 gene"	1	0.375	0.638888889	0.5	0.380952381	0.857142857	0.55	0.3125
304_OG5_128199_0 - ALL_YBR053C	YBR053C	YBR053C - Putative protein of unknown function; induced by cell wall perturbation	1	0.25	0.222222222	0.375	0.619047619	1	0.8	0.125
305_OG5_129173_0 - ALL_Q0250	Q0250	"COX2 - Subunit II of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; one of three mitochondrially-encoded subunits"	1	0.375	0.444444444	0.625	0.333333333	0.857142857	0.55	0.4375
306_OG5_126788_1 - ALL (-ARCHAEA)_YLR259C	YLR259C	HSP60 - Tetradecameric mitochondrial chaperonin required for ATP-dependent folding of precursor polypeptides and complex assembly; prevents aggregation and mediates protein refolding after heat shock; role in mtDNA transmission; phosphorylated	1	0.0625	1	1	1	1	1	0.8125
307_OG5_126915_1 - ALL (-ARCHAEA)_YMR229C	YMR229C	RRP5 - RNA binding protein with preference for single stranded tracts of U's involved in synthesis of both 18S and 5.8S rRNAs; component of both the ribosomal small subunit (SSU) processosome and the 90S preribosome	1	0	0.972222222	1	0.952380952	1	1	0.875
308_OG5_126949_1 - ALL (-ARCHAEA)_YBR025C	YBR025C	OLA1 - P-loop ATPase with similarity to human OLA1 and bacterial YchF; identified as specifically interacting with the proteasome; protein levels are induced by hydrogen peroxide	1	0.0625	1	1	0.904761905	1	1	0.9375
309_OG5_126616_1 - ALL (-ARCHAEA)_YER017C	YER017C	"AFG3 - Component, with Yta12p, of the mitochondrial inner membrane m-AAA protease that mediates degradation of misfolded or unassembled proteins and is also required for correct assembly of mitochondrial enzyme complexes"	1	0	1	1	0.904761905	1	1	0.8125
310_OG5_126616_1 - ALL (-ARCHAEA)_YMR089C	YMR089C	"YTA12 - Component, with Afg3p, of the mitochondrial inner membrane m-AAA protease that mediates degradation of misfolded or unassembled proteins and is also required for correct assembly of mitochondrial enzyme complexes"	1	0	1	1	0.904761905	1	1	0.8125
311_OG5_126616_1 - ALL (-ARCHAEA)_YPR024W	YPR024W	"YME1 - Catalytic subunit of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; mutation causes an elevated rate of mitochondrial turnover"	1	0	1	1	0.904761905	1	1	0.8125
312_OG5_126692_1 - ALL (-ARCHAEA)_YLR069C	YLR069C	MEF1 - Mitochondrial elongation factor involved in translational elongation	1	0	1	1	0.904761905	1	1	0.6875
313_OG5_126692_1 - ALL (-ARCHAEA)_YJL102W	YJL102W	MEF2 - Mitochondrial elongation factor involved in translational elongation	1	0	1	1	0.904761905	1	1	0.6875
314_OG5_126721_1 - ALL (-ARCHAEA)_YLR244C	YLR244C	"MAP1 - Methionine aminopeptidase, catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map2p"	1	0	1	1	0.904761905	1	1	0.6875
315_OG5_126884_1 - ALL (-ARCHAEA)_YGL068W	YGL068W	MNP1 - Protein associated with the mitochondrial nucleoid; putative mitochondrial ribosomal protein with similarity to E. coli L7/L12 ribosomal protein; required for normal respiratory growth	1	0	1	1	0.904761905	1	1	0.6875
316_OG5_127126_1 - ALL (-ARCHAEA)_YOL023W	YOL023W	IFM1 - Mitochondrial translation initiation factor 2	1	0	1	1	0.904761905	1	1	0.625
317_OG5_127170_1 - ALL (-ARCHAEA)_YHR168W	YHR168W	"MTG2 - Putative GTPase, member of the Obg family; peripheral protein of the mitochondrial inner membrane that associates with the large ribosomal subunit; required for mitochondrial translation, possibly via a role in ribosome assembly"	1	0	1	1	0.904761905	1	1	0.6875
318_OG5_127284_1 - ALL (-ARCHAEA)_YLR289W	YLR289W	GUF1 - Mitochondrial matrix GTPase that associates with mitochondrial ribosomes; important for translation under temperature and nutrient stress; may have a role in translational fidelity; similar to bacterial LepA elongation factor	1	0	1	1	0.904761905	1	1	0.5625
319_OG5_127413_1 - ALL (-ARCHAEA)_YPL097W	YPL097W	MSY1 - Mitochondrial tyrosyl-tRNA synthetase	1	0	1	1	0.904761905	1	1	0.5
320_OG5_127078_1 - ALL (-ARCHAEA)_YOR274W	YOR274W	"MOD5 - Delta 2-isopentenyl pyrophosphate:tRNA isopentenyl transferase, required for biosynthesis of the modified base isopentenyladenosine in mitochondrial and cytoplasmic tRNAs; gene is nuclear and encodes two isozymic forms"	1	0	1	1	0.952380952	1	0.95	0.6875
321_OG5_127255_1 - ALL (-ARCHAEA)_YDR116C	YDR116C	MRPL1 - Mitochondrial ribosomal protein of the large subunit	1	0	1	1	0.857142857	1	1	0.5
322_OG5_127423_1 - ALL (-ARCHAEA)_YJL063C	YJL063C	MRPL8 - Mitochondrial ribosomal protein of the large subunit	1	0	1	1	0.857142857	1	1	0.4375
323_OG5_126947_1 - ALL (-ARCHAEA)_YGL143C	YGL143C	"MRF1 - Mitochondrial translation release factor, involved in stop codon recognition and hydrolysis of the peptidyl-tRNA bond during mitochondrial translation; lack of MRF1 causes mitochondrial genome instability"	1	0	1	1	0.904761905	1	0.95	0.6875
324_OG5_127133_1 - ALL (-ARCHAEA)_YGR220C	YGR220C	MRPL9 - Mitochondrial ribosomal protein of the large subunit	1	0	1	1	0.904761905	1	0.95	0.625
325_OG5_126916_1 - ALL (-ARCHAEA)_YDR454C	YDR454C	"GUK1 - Guanylate kinase, converts GMP to GDP; required for growth and mannose outer chain elongation of cell wall N-linked glycoproteins"	1	0	0.972222222	1	0.952380952	0.928571429	1	0.9375
326_OG5_126889_1 - ALL (-ARCHAEA)_YOR241W	YOR241W	"MET7 - Folylpolyglutamate synthetase, catalyzes extension of the glutamate chains of the folate coenzymes, required for methionine synthesis and for maintenance of mitochondrial DNA"	1	0.0625	0.972222222	1	0.857142857	1	1	0.6875
327_OG5_126889_1 - ALL (-ARCHAEA)_YMR113W	YMR113W	"FOL3 - Dihydrofolate synthetase, involved in folic acid biosynthesis; catalyzes the conversion of dihydropteroate to dihydrofolate in folate coenzyme biosynthesis"	1	0.0625	0.972222222	1	0.857142857	1	1	0.6875
328_OG5_127099_1 - ALL (-ARCHAEA)_YJR121W	YJR121W	"ATP2 - Beta subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated"	1	0	0.972222222	1	0.857142857	1	1	0.75
329_OG5_126972_1 - ALL (-ARCHAEA)_YDR037W	YDR037W	KRS1 - Lysyl-tRNA synthetase	1	0.1875	0.861111111	1	0.952380952	1	1	0.9375
330_OG5_127621_1 - ALL (-ARCHAEA)_YOL033W	YOL033W	"MSE1 - Mitochondrial glutamyl-tRNA synthetase, predicted to be palmitoylated"	1	0	1	1	0.80952381	1	1	0.4375
331_OG5_126865_1 - ALL (-ARCHAEA)_YDL036C	YDL036C	"PUS9 - Mitochondrial tRNA:pseudouridine synthase, catalyzes the formation of pseudouridine at position 32 in mitochondrial tRNAs; contains an N-terminal mitochondrial targeting sequence"	1	0.0625	0.972222222	1	0.904761905	0.928571429	1	0.9375
332_OG5_126865_1 - ALL (-ARCHAEA)_YOL066C	YOL066C	RIB2 - Bifunctional enzyme with DRAP deaminase and tRNA:pseudouridine synthase activity; the deaminase catalyzes the third step in riboflavin biosynthesis and the synthase catalyzes formation of pseudouridine at position 32 in cytoplasmic tRNAs	1	0.0625	0.972222222	1	0.904761905	0.928571429	1	0.9375
333_OG5_126954_1 - ALL (-ARCHAEA)_YOR187W	YOR187W	"TUF1 - Mitochondrial translation elongation factor Tu; comprises both GTPase and guanine nucleotide exchange factor activities, while these activities are found in separate proteins in S. pombe and humans"	1	0	0.972222222	1	0.904761905	0.928571429	1	0.6875
334_OG5_127478_1 - ALL (-ARCHAEA)_YBR146W	YBR146W	MRPS9 - Mitochondrial ribosomal protein of the small subunit	1	0	1	1	0.904761905	1	0.9	0.5
335_OG5_127531_1 - ALL (-ARCHAEA)_YDR268W	YDR268W	MSW1 - Mitochondrial tryptophanyl-tRNA synthetase	1	0	1	1	0.904761905	1	0.9	0.4375
336_OG5_127027_1 - ALL (-ARCHAEA)_YJL121C	YJL121C	"RPE1 - D-ribulose-5-phosphate 3-epimerase, catalyzes a reaction in the non-oxidative part of the pentose-phosphate pathway; mutants are sensitive to oxidative stress"	1	0.1875	0.944444444	1	0.857142857	1	1	0.6875
337_OG5_127249_1 - ALL (-ARCHAEA)_YDR298C	YDR298C	"ATP5 - Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is an evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated"	1	0	0.888888889	1	0.904761905	1	1	0.5
338_OG5_127254_1 - ALL (-ARCHAEA)_YDR196C	YDR196C	CAB5 - Probable dephospho-CoA kinase (DPCK) that catalyzes the last step in coenzyme A biosynthesis; null mutant lethality is complemented by E. coli coaE (encoding DPCK); detected in purified mitochondria in high-throughput studies	1	0	1	1	0.857142857	0.928571429	1	0.6875
339_OG5_127198_1 - ALL (-ARCHAEA)_YNL284C	YNL284C	MRPL10 - Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL10 and YmL18) on two-dimensional SDS gels	1	0	1	1	0.904761905	0.928571429	0.95	0.5
340_OG5_127647_1 - ALL (-ARCHAEA)_YHR038W	YHR038W	"RRF1 - Mitochondrial ribosome recycling factor, essential for mitochondrial protein synthesis and for the maintenance of the respiratory function of mitochondria"	1	0	1	1	0.904761905	0.928571429	0.95	0.1875
341_OG5_126628_1 - ALL (-ARCHAEA)_YJR009C	YJR009C	"TDH2 - Glyceraldehyde-3-phosphate dehydrogenase, isozyme 2, involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall"	1	0.125	0.944444444	1	0.904761905	0.928571429	1	1
342_OG5_126628_1 - ALL (-ARCHAEA)_YGR192C	YGR192C	"TDH3 - Glyceraldehyde-3-phosphate dehydrogenase, isozyme 3, involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall"	1	0.125	0.944444444	1	0.904761905	0.928571429	1	1
343_OG5_126628_1 - ALL (-ARCHAEA)_YJL052W	YJL052W	"TDH1 - Glyceraldehyde-3-phosphate dehydrogenase, isozyme 1, involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall"	1	0.125	0.944444444	1	0.904761905	0.928571429	1	1
344_OG5_126734_1 - ALL (-ARCHAEA)_YDR502C	YDR502C	"SAM2 - S-adenosylmethionine synthetase, catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; one of two differentially regulated isozymes (Sam1p and Sam2p)"	1	0.0625	0.944444444	0.875	0.952380952	1	1	0.875
345_OG5_126734_1 - ALL (-ARCHAEA)_YLR180W	YLR180W	"SAM1 - S-adenosylmethionine synthetase, catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; one of two differentially regulated isozymes (Sam1p and Sam2p)"	1	0.0625	0.944444444	0.875	0.952380952	1	1	0.875
346_OG5_127201_1 - ALL (-ARCHAEA)_YMR167W	YMR167W	MLH1 - Protein required for mismatch repair in mitosis and meiosis as well as crossing over during meiosis; forms a complex with Pms1p and Msh2p-Msh3p during mismatch repair; human homolog is associated with hereditary non-polyposis colon cancer	1	0.125	0.861111111	1	0.904761905	1	1	1
347_OG5_127174_1 - ALL (-ARCHAEA)_YBL036C	YBL036C	YBL036C - Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS	1	0	0.861111111	1	0.952380952	1	0.95	0.8125
348_OG5_127268_1 - ALL (-ARCHAEA)_YOR150W	YOR150W	MRPL23 - Mitochondrial ribosomal protein of the large subunit	1	0	1	1	0.761904762	1	1	0.6875
349_OG5_127316_1 - ALL (-ARCHAEA)_YML025C	YML025C	"YML6 - Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosomal proteins"	1	0	1	1	0.904761905	0.857142857	1	0.5625
350_OG5_126895_1 - ALL (-ARCHAEA)_YHR120W	YHR120W	"MSH1 - DNA-binding protein of the mitochondria involved in repair of mitochondrial DNA, has ATPase activity and binds to DNA mismatches; has homology to E. coli MutS; transcription is induced during meiosis"	1	0.1875	0.805555556	1	0.952380952	1	1	0.9375
351_OG5_126895_1 - ALL (-ARCHAEA)_YDR097C	YDR097C	"MSH6 - Protein required for mismatch repair in mitosis and meiosis, forms a complex with Msh2p to repair both single-base & insertion-deletion mispairs; potentially phosphorylated by Cdc28p"	1	0.1875	0.805555556	1	0.952380952	1	1	0.9375
352_OG5_127028_1 - ALL (-ARCHAEA)_YKL192C	YKL192C	"ACP1 - Mitochondrial matrix acyl carrier protein, involved in biosynthesis of octanoate, which is a precursor to lipoic acid; activated by phosphopantetheinylation catalyzed by Ppt2p"	1	0	1	1	0.857142857	0.928571429	0.95	0.625
353_OG5_126596_1 - ALL (-ARCHAEA)_YKL209C	YKL209C	"STE6 - Plasma membrane ATP-binding cassette (ABC) transporter required for the export of a-factor, catalyzes ATP hydrolysis coupled to a-factor transport; contains 12 transmembrane domains and two ATP binding domains; expressed only in MATa cells"	1	0.125	0.777777778	1	0.952380952	1	1	0.5625
354_OG5_127361_1 - ALL (-ARCHAEA)_YNL005C	YNL005C	MRP7 - Mitochondrial ribosomal protein of the large subunit	1	0	1	1	0.761904762	1	0.95	0.4375
355_OG5_126936_1 - ALL (-ARCHAEA)_YER168C	YER168C	"CCA1 - ATP (CTP):tRNA-specific tRNA nucleotidyltransferase; different forms targeted to the nucleus, cytosol, and mitochondrion are generated via the use of multiple transcriptional and translational start sites"	1	0	0.805555556	1	0.904761905	1	1	0.9375
356_OG5_126769_1 - ALL (-ARCHAEA)_YOR020C	YOR020C	"HSP10 - Mitochondrial matrix co-chaperonin that inhibits the ATPase activity of Hsp60p, a mitochondrial chaperonin; involved in protein folding and sorting in the mitochondria; 10 kD heat shock protein with similarity to E. coli groES"	1	0	1	1	0.952380952	0.857142857	0.9	0.8125
357_OG5_126903_1 - ALL (-ARCHAEA)_YKR056W	YKR056W	"TRM2 - tRNA methyltransferase, 5-methylates the uridine residue at position 54 of tRNAs and may also have a role in tRNA stabilization or maturation; endo-exonuclease with a role in DNA repair"	1	0.0625	0.75	1	0.952380952	1	1	0.625
358_OG5_127662_1 - ALL (-ARCHAEA)_YPL104W	YPL104W	"MSD1 - Mitochondrial aspartyl-tRNA synthetase, required for acylation of aspartyl-tRNA; yeast and bacterial aspartyl-, asparaginyl-, and lysyl-tRNA synthetases contain regions with high sequence similarity, suggesting a common ancestral gene"	1	0	1	1	0.761904762	0.928571429	1	0.125
359_OG5_127077_1 - ALL (-ARCHAEA)_YBR039W	YBR039W	"ATP3 - Gamma subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis"	1	0	0.916666667	1	0.904761905	0.857142857	1	0.6875
360_OG5_127309_1 - ALL (-ARCHAEA)_YLR401C	YLR401C	"DUS3 - Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region"	1	0	0.888888889	1	0.857142857	0.928571429	1	0.5625
361_OG5_127002_1 - ALL (-ARCHAEA)_YDR050C	YDR050C	"TPI1 - Triose phosphate isomerase, abundant glycolytic enzyme; mRNA half-life is regulated by iron availability; transcription is controlled by activators Reb1p, Gcr1p, and Rap1p through binding sites in the 5' non-coding region"	1	0	0.888888889	1	0.904761905	0.928571429	0.95	0.875
362_OG5_127603_1 - ALL (-ARCHAEA)_YPL013C	YPL013C	MRPS16 - Mitochondrial ribosomal protein of the small subunit	1	0	1	1	0.857142857	0.857142857	0.95	0.125
363_OG5_126991_1 - ALL (-ARCHAEA)_YBL022C	YBL022C	"PIM1 - ATP-dependent Lon protease, involved in degradation of misfolded proteins in mitochondria; required for biogenesis and maintenance of mitochondria"	1	0	0.75	1	0.904761905	1	1	0.5
364_OG5_126704_1 - ALL (-ARCHAEA)_YOL059W	YOL059W	"GPD2 - NAD-dependent glycerol 3-phosphate dehydrogenase, homolog of Gpd1p, expression is controlled by an oxygen-independent signaling pathway required to regulate metabolism under anoxic conditions; located in cytosol and mitochondria"	1	0.125	0.944444444	1	0.80952381	1	0.9	0.875
365_OG5_126704_1 - ALL (-ARCHAEA)_YDL022W	YDL022W	"GPD1 - NAD-dependent glycerol-3-phosphate dehydrogenase, key enzyme of glycerol synthesis, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway; homolog of Gpd2p"	1	0.125	0.944444444	1	0.80952381	1	0.9	0.875
366_OG5_126623_1 - ALL (-ARCHAEA)_YPL240C	YPL240C	"HSP82 - Hsp90 chaperone required for pheromone signaling and negative regulation of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding and nucleotide addition; interacts with Cns1p, Cpr6p, Cpr7p, Sti1p"	1	0	0.638888889	1	1	1	1	1
367_OG5_126623_1 - ALL (-ARCHAEA)_YMR186W	YMR186W	"HSC82 - Cytoplasmic chaperone of the Hsp90 family, redundant in function and nearly identical with Hsp82p, and together they are essential; expressed constitutively at 10-fold higher basal levels than HSP82 and induced 2-3 fold by heat shock"	1	0	0.638888889	1	1	1	1	1
368_OG5_127058_1 - ALL (-ARCHAEA)_YOL021C	YOL021C	DIS3 - Exosome core complex catalytic subunit; possesses both endonuclease and 3'-5' exonuclease activity; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase R and to human DIS3	1	0.125	0.805555556	0.875	0.952380952	1	1	1
369_OG5_127362_1 - ALL (-ARCHAEA)_YDR148C	YDR148C	"KGD2 - Dihydrolipoyl transsuccinylase, component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes the oxidative decarboxylation of alpha-ketoglutarate to succinyl-CoA in the TCA cycle; phosphorylated"	1	0.0625	0.722222222	1	0.904761905	1	1	0.6875
370_OG5_127675_1 - ALL (-ARCHAEA)_YLR382C	YLR382C	"NAM2 - Mitochondrial leucyl-tRNA synthetase, also has a direct role in splicing of several mitochondrial group I introns; indirectly required for mitochondrial genome maintenance"	1	0.125	1	1	0.80952381	1	0.8	0.4375
371_OG5_126985_1 - ALL (-ARCHAEA)_YER061C	YER061C	CEM1 - Mitochondrial beta-keto-acyl synthase with possible role in fatty acid synthesis; required for mitochondrial respiration	1	0	0.972222222	1	0.904761905	0.928571429	0.8	0.5625
372_OG5_127404_1 - ALL (-ARCHAEA)_YDL004W	YDL004W	"ATP16 - Delta subunit of the central stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated"	1	0	0.916666667	1	0.80952381	0.928571429	0.95	0.625
373_OG5_127510_1 - ALL (-ARCHAEA)_YOR176W	YOR176W	"HEM15 - Ferrochelatase, a mitochondrial inner membrane protein, catalyzes the insertion of ferrous iron into protoporphyrin IX, the eighth and final step in the heme biosynthetic pathway"	1	0.0625	0.833333333	1	0.761904762	1	1	0.375
374_OG5_127663_1 - ALL (-ARCHAEA)_YDR337W	YDR337W	MRPS28 - Mitochondrial ribosomal protein of the small subunit	1	0	1	1	0.666666667	0.928571429	1	0.4375
375_OG5_126934_1 - ALL (-ARCHAEA)_YFR009W	YFR009W	"GCN20 - Positive regulator of the Gcn2p kinase activity, forms a complex with Gcn1p; proposed to stimulate Gcn2p activation by an uncharged tRNA"	1	0	0.833333333	1	0.952380952	0.857142857	0.95	0.8125
376_OG5_126904_1 - ALL (-ARCHAEA)_YDL052C	YDL052C	"SLC1 - 1-acyl-sn-glycerol-3-phosphate acyltransferase, catalyzes the acylation of lysophosphatidic acid to form phosphatidic acid, a key intermediate in lipid metabolism; enzymatic activity detected in lipid particles and microsomes"	1	0	0.833333333	1	0.80952381	0.928571429	1	0.6875
377_OG5_126758_1 - ALL (-ARCHAEA)_YGR240C	YGR240C	"PFK1 - Alpha subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes"	1	0.0625	0.666666667	1	0.904761905	1	1	0.375
378_OG5_126758_1 - ALL (-ARCHAEA)_YMR205C	YMR205C	"PFK2 - Beta subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes"	1	0.0625	0.666666667	1	0.904761905	1	1	0.375
379_OG5_126779_1 - ALL (-ARCHAEA)_YIL125W	YIL125W	"KGD1 - Component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes a key step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutarate to form succinyl-CoA"	1	0	0.666666667	1	0.904761905	1	1	0.625
380_OG5_127165_1 - ALL (-ARCHAEA)_YBL099W	YBL099W	"ATP1 - Alpha subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated"	1	0	0.916666667	0.75	0.904761905	1	1	0.6875
381_OG5_127023_1 - ALL (-ARCHAEA)_YLR163C	YLR163C	"MAS1 - Smaller subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins"	1	0.125	0.611111111	1	0.952380952	1	1	0.8125
382_OG5_127348_1 - ALL (-ARCHAEA)_YOR196C	YOR196C	"LIP5 - Protein involved in biosynthesis of the coenzyme lipoic acid, has similarity to E. coli lipoic acid synthase"	1	0.125	0.75	1	0.80952381	1	1	0.5
383_OG5_127373_1 - ALL (-ARCHAEA)_YDL142C	YDL142C	"CRD1 - Cardiolipin synthase; produces cardiolipin, which is a phospholipid of the mitochondrial inner membrane that is required for normal mitochondrial membrane potential and function; also required for normal vacuolar ion homeostasis"	1	0	0.944444444	1	0.857142857	0.857142857	0.9	0.375
384_OG5_127722_1 - ALL (-ARCHAEA)_YMR023C	YMR023C	"MSS1 - Mitochondrial protein, forms a heterodimer complex with Mto1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; similar to human GTPBP3"	1	0.0625	0.916666667	1	0.80952381	0.928571429	0.9	0.25
385_OG5_127347_1 - ALL (-ARCHAEA)_YDR047W	YDR047W	"HEM12 - Uroporphyrinogen decarboxylase, catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; a hem12 mutant has phenotypes similar to patients with porphyria cutanea tarda"	1	0.125	0.861111111	1	0.761904762	0.928571429	1	0.3125
386_OG5_127161_1 - ALL (-ARCHAEA)_YDR236C	YDR236C	"FMN1 - Riboflavin kinase, phosphorylates riboflavin to form riboflavin monophosphate (FMN), which is a necessary cofactor for many enzymes; localizes to microsomes and to the mitochondrial inner membrane"	1	0	0.944444444	1	0.714285714	0.928571429	0.95	0.8125
387_OG5_126644_1 - ALL (-ARCHAEA)_YMR190C	YMR190C	SGS1 - Nucleolar DNA helicase of the RecQ family; involved in genome integrity maintenance; regulates chromosome synapsis and meiotic joint molecule/crossover formation; potential role as repressor of a subset of rapamycin responsive genes; rapidly lost in response to rapamycin in Rrd1p-dependent manner; similar to human BLM and WRN proteins implicated in Bloom and Werner syndromes	1	0	0.583333333	1	0.952380952	1	1	1
388_OG5_127775_1 - ALL (-ARCHAEA)_YGL236C	YGL236C	"MTO1 - Mitochondrial protein, forms a heterodimer complex with Mss1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; required for respiration in paromomycin-resistant 15S rRNA mutants"	1	0	0.916666667	1	0.857142857	0.857142857	0.9	0.4375
389_OG5_126992_1 - ALL (-ARCHAEA)_YBR252W	YBR252W	"DUT1 - deoxyuridine triphosphate diphosphatase (dUTPase); catalyzes hydrolysis of dUTP to dUMP and PPi, thereby preventing incorporation of uracil into DNA during replication; critical for the maintenance of genetic stability; also has diphosphatase activity on deoxyinosine triphosphate"	1	0.0625	0.694444444	1	0.904761905	0.928571429	1	0.6875
390_OG5_127763_1 - ALL (-ARCHAEA)_YOR323C	YOR323C	"PRO2 - Gamma-glutamyl phosphate reductase, catalyzes the second step in proline biosynthesis"	1	0.0625	0.805555556	1	0.714285714	1	1	0.375
391_OG5_127517_1 - ALL (-ARCHAEA)_YBL038W	YBL038W	MRPL16 - Mitochondrial ribosomal protein of the large subunit	1	0	1	0.875	0.714285714	0.928571429	1	0.4375
392_OG5_126941_1 - ALL (-ARCHAEA)_YPR062W	YPR062W	"FCY1 - Cytosine deaminase, zinc metalloenzyme that catalyzes the hydrolytic deamination of cytosine to uracil; of biomedical interest because it also catalyzes the deamination of 5-fluorocytosine (5FC) to form anticancer drug 5-fluorouracil (5FU)"	1	0.1875	0.888888889	1	0.666666667	0.928571429	1	0.9375
393_OG5_126941_1 - ALL (-ARCHAEA)_YJL035C	YJL035C	"TAD2 - Subunit of tRNA-specific adenosine-34 deaminase, forms a heterodimer with Tad3p that converts adenosine to inosine at the wobble position of several tRNAs"	1	0.1875	0.888888889	1	0.666666667	0.928571429	1	0.9375
394_OG5_128011_1 - ALL (-ARCHAEA)_YBR227C	YBR227C	MCX1 - Mitochondrial matrix protein; putative ATP-binding chaperone with non-proteolytic function; similar to bacterial ClpX proteins	1	0	0.972222222	1	0.80952381	1	0.7	0.1875
395_OG5_128023_1 - ALL (-ARCHAEA)_YNL026W	YNL026W	"SAM50 - Essential component of the Sorting and Assembly Machinery (SAM or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; homologous to bacterial Omp85"	1	0	0.722222222	1	0.80952381	1	0.95	0.125
396_OG5_127575_1 - ALL (-ARCHAEA)_YPR166C	YPR166C	MRP2 - Mitochondrial ribosomal protein of the small subunit	1	0	0.972222222	0.75	0.80952381	0.928571429	1	0.375
397_OG5_127793_1 - ALL (-ARCHAEA)_YBL013W	YBL013W	"FMT1 - Methionyl-tRNA formyltransferase, catalyzes the formylation of initiator Met-tRNA in mitochondria; potential Cdc28p substrate"	1	0.0625	1	1	0.666666667	0.785714286	1	0.3125
398_OG5_128026_1 - ALL (-ARCHAEA)_YGR021W	YGR021W	"YGR021W - Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"	1	0	1	1	0.714285714	0.785714286	0.95	0.125
399_OG5_127179_1 - ALL (-ARCHAEA)_YDL201W	YDL201W	TRM8 - Subunit of a tRNA methyltransferase complex composed of Trm8p and Trm82p that catalyzes 7-methylguanosine modification of tRNA	1	0	0.805555556	1	0.904761905	0.785714286	0.95	0.9375
400_OG5_126599_1 - ALL (-ARCHAEA)_YKR086W	YKR086W	"PRP16 - DEAH-box RNA helicase involved in second catalytic step of splicing; exhibits ATP-dependent RNA unwinding activity; mediates the release of Yju2p and Cwc25p in the second step; in the absence of ATP, stabilizes the binding of Cwc25p to the spliceosome in the first catalytic step"	1	0	0.444444444	1	1	1	1	1
401_OG5_126599_1 - ALL (-ARCHAEA)_YER013W	YER013W	"PRP22 - DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase, associates with lariat intermediates before the second catalytic step of splicing; mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes"	1	0	0.444444444	1	1	1	1	1
402_OG5_126599_1 - ALL (-ARCHAEA)_YGL120C	YGL120C	"PRP43 - RNA helicase in the DEAH-box family, functions in both RNA polymerase I and polymerase II transcript metabolism, involved in release of the lariat-intron from the spliceosome"	1	0	0.444444444	1	1	1	1	1
403_OG5_126599_1 - ALL (-ARCHAEA)_YNR011C	YNR011C	"PRP2 - RNA-dependent ATPase in the DEAH-box family, required for activation of the spliceosome before the first transesterification step in RNA splicing; orthologous to human protein DHX16"	1	0	0.444444444	1	1	1	1	1
404_OG5_127113_1 - ALL (-ARCHAEA)_YNL088W	YNL088W	"TOP2 - Topoisomerase II, relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone of both positively and negatively supercoiled DNA; cleaves complementary strands; localizes to axial cores in meiosis"	1	0	0.527777778	1	0.952380952	1	0.95	1
405_OG5_126823_1 - ALL (-ARCHAEA)_YJL026W	YJL026W	"RNR2 - Ribonucleotide-diphosphate reductase (RNR), small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits"	1	0.1875	0.638888889	1	0.857142857	0.928571429	1	0.875
406_OG5_127670_1 - ALL (-ARCHAEA)_YOL096C	YOL096C	"COQ3 - O-methyltransferase, catalyzes two different O-methylation steps in ubiquinone (Coenzyme Q) biosynthesis; component of a mitochondrial ubiquinone-synthesizing complex; phosphoprotein"	1	0	0.5	1	0.904761905	1	1	0.75
407_OG5_127541_1 - ALL (-ARCHAEA)_YDL219W	YDL219W	"DTD1 - D-Tyr-tRNA(Tyr) deacylase, functions in protein translation, may affect nonsense suppression via alteration of the protein synthesis machinery; ubiquitous among eukaryotes"	1	0	0.666666667	1	0.857142857	0.928571429	0.95	0.625
408_OG5_127019_1 - ALL (-ARCHAEA)_YCL033C	YCL033C	"MXR2 - Methionine-R-sulfoxide reductase, involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR1; involved in the regulation of lifespan"	1	0.1875	0.638888889	1	0.80952381	1	0.95	0.5625
409_OG5_127226_1 - ALL (-ARCHAEA)_YMR105C	YMR105C	"PGM2 - Phosphoglucomutase, catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism; functions as the acceptor for a Glc-phosphotransferase"	1	0.1875	0.444444444	1	0.952380952	1	1	0.4375
410_OG5_127226_1 - ALL (-ARCHAEA)_YKL127W	YKL127W	"PGM1 - Phosphoglucomutase, minor isoform; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism"	1	0.1875	0.444444444	1	0.952380952	1	1	0.4375
411_OG5_126984_1 - ALL (-ARCHAEA)_YJL138C	YJL138C	"TIF2 - Translation initiation factor eIF4A, identical to Tif1p; DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4G"	1	0.125	0.527777778	1	0.857142857	1	1	1
412_OG5_126984_1 - ALL (-ARCHAEA)_YKR059W	YKR059W	"TIF1 - Translation initiation factor eIF4A, identical to Tif2p; DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4G"	1	0.125	0.527777778	1	0.857142857	1	1	1
413_OG5_127579_1 - ALL (-ARCHAEA)_YEL011W	YEL011W	"GLC3 - Glycogen branching enzyme, involved in glycogen accumulation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern"	1	0	0.527777778	1	0.904761905	1	0.95	0.375
414_OG5_127121_1 - ALL (-ARCHAEA)_YNL241C	YNL241C	"ZWF1 - Glucose-6-phosphate dehydrogenase (G6PD), catalyzes the first step of the pentose phosphate pathway; involved in adapting to oxidatve stress; homolog of the human G6PD which is deficient in patients with hemolytic anemia"	1	0	0.638888889	1	0.80952381	0.928571429	1	0.875
415_OG5_126785_1 - ALL (-ARCHAEA)_YPL091W	YPL091W	"GLR1 - Cytosolic and mitochondrial glutathione oxidoreductase, converts oxidized glutathione to reduced glutathione; mitochondrial but not cytosolic form has a role in resistance to hyperoxia"	1	0.125	0.472222222	1	0.904761905	1	1	0.6875
416_OG5_127291_1 - ALL (-ARCHAEA)_YDR272W	YDR272W	"GLO2 - Cytoplasmic glyoxalase II, catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate"	1	0.125	0.472222222	1	0.904761905	1	1	0.875
417_OG5_127291_1 - ALL (-ARCHAEA)_YOR040W	YOR040W	"GLO4 - Mitochondrial glyoxalase II, catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate"	1	0.125	0.472222222	1	0.904761905	1	1	0.875
418_OG5_128078_1 - ALL (-ARCHAEA)_YNL063W	YNL063W	MTQ1 - S-adenosylmethionine-dependent methyltransferase; methylates translational release factor Mrf1p; similar to E.coli PrmC; is not an essential gene	1	0	0.972222222	1	0.571428571	0.928571429	0.9	0.25
419_OG5_127385_1 - ALL (-ARCHAEA)_YOR074C	YOR074C	"CDC21 - Thymidylate synthase, required for de novo biosynthesis of pyrimidine deoxyribonucleotides; expression is induced at G1/S"	1	0.0625	0.583333333	1	0.857142857	0.928571429	1	0.8125
420_OG5_127468_1 - ALL (-ARCHAEA)_YGR171C	YGR171C	"MSM1 - Mitochondrial methionyl-tRNA synthetase (MetRS), functions as a monomer in mitochondrial protein synthesis; functions similarly to cytoplasmic MetRS although the cytoplasmic form contains a zinc-binding domain not found in Msm1p"	1	0.0625	0.555555556	1	0.80952381	1	1	0.875
421_OG5_126636_1 - ALL (-ARCHAEA)_YDR258C	YDR258C	HSP78 - Oligomeric mitochondrial matrix chaperone that cooperates with Ssc1p in mitochondrial thermotolerance after heat shock; able to prevent the aggregation of misfolded proteins as well as resolubilize protein aggregates	1	0	1	1	0.571428571	0.785714286	1	0.875
422_OG5_126636_1 - ALL (-ARCHAEA)_YLL026W	YLL026W	"HSP104 - Heat shock protein that cooperates with Ydj1p (Hsp40) and Ssa1p (Hsp70) to refold and reactivate previously denatured, aggregated proteins; responsive to stresses including: heat, ethanol, and sodium arsenite; involved in [PSI+] propagation"	1	0	1	1	0.571428571	0.785714286	1	0.875
423_OG5_127189_1 - ALL (-ARCHAEA)_YLL029W	YLL029W	"FRA1 - Protein involved in negative regulation of transcription of iron regulon; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; cytosolic; mutant fails to repress transcription of iron regulon and is defective in spore formation"	1	0.0625	0.388888889	1	0.952380952	1	1	0.8125
424_OG5_127091_1 - ALL (-ARCHAEA)_YLR207W	YLR207W	"HRD3 - Resident protein of the ER membrane that plays a central role in ER-associated protein degradation (ERAD), forms HRD complex with Hrd1p and ERAD determinants that engages in lumen to cytosol communication and coordination of ERAD events"	1	0	0.388888889	1	0.952380952	1	1	0.875
425_OG5_127175_1 - ALL (-ARCHAEA)_YHR183W	YHR183W	"GND1 - 6-phosphogluconate dehydrogenase (decarboxylating), catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone and adaptation to oxidative stress"	1	0.1875	0.666666667	1	0.80952381	0.857142857	1	0.875
426_OG5_127175_1 - ALL (-ARCHAEA)_YGR256W	YGR256W	"GND2 - 6-phosphogluconate dehydrogenase (decarboxylating), catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone"	1	0.1875	0.666666667	1	0.80952381	0.857142857	1	0.875
427_OG5_127222_1 - ALL (-ARCHAEA)_YLL027W	YLL027W	"ISA1 - Mitochondrial matrix protein involved in biogenesis of the iron-sulfur (Fe/S) cluster of Fe/S proteins, isa1 deletion causes loss of mitochondrial DNA and respiratory deficiency; depletion reduces growth on nonfermentable carbon sources"	1	0.0625	0.5	1	0.904761905	0.928571429	1	0.625
428_OG5_127383_1 - ALL (-ARCHAEA)_YDL033C	YDL033C	"SLM3 - tRNA-specific 2-thiouridylase, responsible for 2-thiolation of the wobble base of mitochondrial tRNAs; human ortholog is implicated in myoclonus epilepsy associated with ragged red fibers (MERRF)"	1	0	0.972222222	1	0.761904762	0.928571429	0.65	0.625
429_OG5_127997_1 - ALL (-ARCHAEA)_YER183C	YER183C	"FAU1 - 5,10-methenyltetrahydrofolate synthetase, involved in folic acid biosynthesis"	1	0.0625	0.916666667	0.75	0.761904762	0.928571429	0.95	0.25
430_OG5_127554_1 - ALL (-ARCHAEA)_YOR111W	YOR111W	YOR111W - Putative protein of unknown function	1	0.0625	0.833333333	0.875	0.857142857	0.785714286	0.95	0.625
431_OG5_127400_1 - ALL (-ARCHAEA)_YLR377C	YLR377C	"FBP1 - Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism; undergoes either proteasome-mediated or autophagy-mediated degradation depending on growth conditions; interacts with Vid30p"	1	0.125	0.388888889	1	0.904761905	1	1	0.4375
432_OG5_127867_1 - ALL (-ARCHAEA)_YJR113C	YJR113C	"RSM7 - Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S7 ribosomal protein"	1	0	1	0.625	0.714285714	1	0.95	0.125
433_OG5_128046_1 - ALL (-ARCHAEA)_YHL004W	YHL004W	MRP4 - Mitochondrial ribosomal protein of the small subunit	1	0	1	0.5	0.857142857	0.928571429	1	0.125
434_OG5_126727_1 - ALL (-ARCHAEA)_YNL135C	YNL135C	"FPR1 - Peptidyl-prolyl cis-trans isomerase (PPIase), binds to the drugs FK506 and rapamycin; also binds to the nonhistone chromatin binding protein Hmo1p and may regulate its assembly or function"	1	0	0.277777778	1	1	1	1	0.6875
435_OG5_127879_1 - ALL (-ARCHAEA)_YOR001W	YOR001W	"RRP6 - Nuclear exosome exonuclease component; has 3'-5' exonuclease activity; involved in RNA processing, maturation, surveillance, degradation, tethering, and export; has similarity to E. coli RNase D and to human PM-Sc1 100 (EXOSC10)"	1	0	0.444444444	0.875	0.952380952	1	1	0.5625
436_OG5_126999_1 - ALL (-ARCHAEA)_YPR160W	YPR160W	"GPH1 - Non-essential glycogen phosphorylase required for the mobilization of glycogen, activity is regulated by cyclic AMP-mediated phosphorylation, expression is regulated by stress-response elements and by the HOG MAP kinase pathway"	1	0	0.416666667	1	0.904761905	1	0.95	0.375
437_OG5_126849_1 - ALL (-ARCHAEA)_YPL119C	YPL119C	DBP1 - Putative ATP-dependent RNA helicase of the DEAD-box protein family; mutants show reduced stability of the 40S ribosomal subunit scanning through 5' untranslated regions of mRNAs	1	0.125	0.361111111	1	0.904761905	1	1	0.9375
438_OG5_126849_1 - ALL (-ARCHAEA)_YOR204W	YOR204W	"DED1 - ATP-dependent DEAD (Asp-Glu-Ala-Asp)-box RNA helicase, required for translation initiation of all yeast mRNAs; mutations in human DEAD-box DBY are a frequent cause of male infertility"	1	0.125	0.361111111	1	0.904761905	1	1	0.9375
439_OG5_127216_1 - ALL (-ARCHAEA)_YER178W	YER178W	"PDA1 - E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex, catalyzes the direct oxidative decarboxylation of pyruvate to acetyl-CoA; phosphorylated; regulated by glucose"	1	0.125	0.361111111	1	0.904761905	1	1	0.5625
440_OG5_126897_1 - ALL (-ARCHAEA)_YPL270W	YPL270W	"MDL2 - Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter, required for respiratory growth at high temperature; similar to human TAP1 and TAP2 implicated in bare lymphocyte syndrome and Wegener-like granulomatosis"	1	0	0.611111111	0.75	0.904761905	1	1	0.6875
441_OG5_126897_1 - ALL (-ARCHAEA)_YLR188W	YLR188W	"MDL1 - Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter, mediates export of peptides generated upon proteolysis of mitochondrial proteins, plays a role in the regulation of cellular resistance to oxidative stress"	1	0	0.611111111	0.75	0.904761905	1	1	0.6875
442_OG5_127097_1 - ALL (-ARCHAEA)_YOL122C	YOL122C	SMF1 - Divalent metal ion transporter with a broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins	1	0.0625	0.5	1	0.761904762	1	1	0.3125
443_OG5_127097_1 - ALL (-ARCHAEA)_YLR034C	YLR034C	SMF3 - Putative divalent metal ion transporter involved in iron homeostasis; transcriptionally regulated by metal ions; member of the Nramp family of metal transport proteins	1	0.0625	0.5	1	0.761904762	1	1	0.3125
444_OG5_128427_1 - ALL (-ARCHAEA)_YOR184W	YOR184W	"SER1 - 3-phosphoserine aminotransferase, catalyzes the formation of phosphoserine from 3-phosphohydroxypyruvate, required for serine and glycine biosynthesis; regulated by the general control of amino acid biosynthesis mediated by Gcn4p"	1	0.0625	0.472222222	1	0.857142857	0.928571429	1	0.1875
445_OG5_127572_1 - ALL (-ARCHAEA)_YEL052W	YEL052W	AFG1 - Conserved protein that may act as a chaperone in the degradation of misfolded or unassembled cytochrome c oxidase subunits; localized to matrix face of the mitochondrial inner membrane; member of the AAA family but lacks a protease domain	1	0	0.472222222	1	0.857142857	0.928571429	1	0.625
446_OG5_126711_1 - ALL (-ARCHAEA)_YIR037W	YIR037W	HYR1 - Thiol peroxidase that functions as a hydroperoxide receptor to sense intracellular hydroperoxide levels and transduce a redox signal to the Yap1p transcription factor	1	0	0.444444444	1	0.80952381	1	1	0.75
447_OG5_126711_1 - ALL (-ARCHAEA)_YBR244W	YBR244W	GPX2 - Phospholipid hydroperoxide glutathione peroxidase induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress	1	0	0.444444444	1	0.80952381	1	1	0.75
448_OG5_126711_1 - ALL (-ARCHAEA)_YKL026C	YKL026C	GPX1 - Phospholipid hydroperoxide glutathione peroxidase induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress	1	0	0.444444444	1	0.80952381	1	1	0.75
449_OG5_126826_1 - ALL (-ARCHAEA)_YNL305C	YNL305C	BXI1 - Protein involved in apoptosis; variously described as containing a BCL-2 homology (BH3) domain or as a member of the BAX inhibitor family; reported to promote apoptosis under some conditions and to inhibit it in others; localizes to ER and vacuole; may link the unfolded protein response to apoptosis via regulation of calcium-mediated signaling; translocates to mitochondria under apoptosis-inducing conditions in a process involving Mir1p and Cor1p	1	0	0.694444444	0.75	0.857142857	1	0.95	0.5625
450_OG5_127162_1 - ALL (-ARCHAEA)_YHR042W	YHR042W	NCP1 - NADP-cytochrome P450 reductase; involved in ergosterol biosynthesis; associated and coordinately regulated with Erg11p	1	0	0.416666667	1	0.904761905	0.928571429	1	0.8125
451_OG5_127060_1 - ALL (-ARCHAEA)_YKL033W-A	YKL033W-A	YKL033W-A - Putative protein of unknown function; similar to uncharacterized proteins from other fungi	1	0	0.611111111	0.875	0.80952381	1	0.95	0.25
452_OG5_126674_1 - ALL (-ARCHAEA)_YGL167C	YGL167C	PMR1 - High affinity Ca2+/Mn2+ P-type ATPase required for Ca2+ and Mn2+ transport into Golgi; involved in Ca2+ dependent protein sorting and processing; mutations in human homolog ATP2C1 cause acantholytic skin condition Hailey-Hailey disease	1	0.125	0.333333333	1	0.904761905	1	1	0.8125
453_OG5_128228_1 - ALL (-ARCHAEA)_YDR044W	YDR044W	"HEM13 - Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; transcription is repressed by oxygen and heme (via Rox1p and Hap1p)"	1	0	0.472222222	1	0.761904762	1	1	0.375
454_OG5_126945_1 - ALL (-ARCHAEA)_YML054C	YML054C	"CYB2 - Cytochrome b2 (L-lactate cytochrome-c oxidoreductase), component of the mitochondrial intermembrane space, required for lactate utilization; expression is repressed by glucose and anaerobic conditions"	1	0.125	0.472222222	1	0.80952381	1	0.95	0.0625
455_OG5_127463_1 - ALL (-ARCHAEA)_YPR067W	YPR067W	"ISA2 - Protein required for maturation of mitochondrial and cytosolic Fe/S proteins, localizes to the mitochondrial intermembrane space, overexpression of ISA2 suppresses grx5 mutations"	1	0.0625	0.638888889	1	0.904761905	0.785714286	0.9	0.625
456_OG5_126737_1 - ALL (-ARCHAEA)_YKL106W	YKL106W	"AAT1 - Mitochondrial aspartate aminotransferase, catalyzes the conversion of oxaloacetate to aspartate in aspartate and asparagine biosynthesis"	1	0	0.305555556	1	0.904761905	1	1	0.8125
457_OG5_126737_1 - ALL (-ARCHAEA)_YLR027C	YLR027C	"AAT2 - Cytosolic aspartate aminotransferase, involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells"	1	0	0.305555556	1	0.904761905	1	1	0.8125
458_OG5_127329_1 - ALL (-ARCHAEA)_YLR118C	YLR118C	YLR118C - Acyl-protein thioesterase responsible for depalmitoylation of Gpa1p; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced in response to the DNA-damaging agent MMS	1	0	0.305555556	1	0.904761905	1	1	0.5
459_OG5_128116_1 - ALL (-ARCHAEA)_YGR255C	YGR255C	COQ6 - Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS)	1	0	0.472222222	1	0.80952381	0.928571429	1	0.3125
460_OG5_127728_1 - ALL (-ARCHAEA)_YMR239C	YMR239C	RNT1 - RNAase III; involved in rDNA transcription and rRNA processing; also cleaves a stem-loop structure at the 3' end of U2 snRNA to ensure formation of the correct U2 3' end; involved in polyadenylation-independent transcription termination	1	0.125	0.972222222	0.625	0.761904762	1	0.85	0.1875
461_OG5_127295_1 - ALL (-ARCHAEA)_YPL059W	YPL059W	GRX5 - Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; mitochondrial matrix protein involved in the synthesis/assembly of iron-sulfur centers; monothiol glutaredoxin subfamily member along with Grx3p and Grx4p	1	0.125	0.472222222	1	0.857142857	0.928571429	0.95	0.6875
462_OG5_126621_1 - ALL (-ARCHAEA)_YOR246C	YOR246C	"YOR246C - Protein with similarity to oxidoreductases, found in lipid particles; required for replication of Brome mosaic virus in S. cerevisiae, a model system for studying replication of positive-strand RNA viruses in their natural hosts"	1	0.125	0.25	1	0.952380952	1	1	0.75
463_OG5_126729_1 - ALL (-ARCHAEA)_YDR456W	YDR456W	"NHX1 - Na+/H+ and K+/H+ exchanger, required for intracellular sequestration of Na+ and K+; located in the vacuole and late endosome compartments; required for osmotolerance to acute hypertonic shock and for vacuolar fusion"	1	0.125	0.25	1	0.952380952	1	1	0.5
464_OG5_126772_1 - ALL (-ARCHAEA)_YNL112W	YNL112W	"DBP2 - Essential ATP-dependent RNA helicase of the DEAD-box protein family, involved in nonsense-mediated mRNA decay and rRNA processing"	1	0.0625	0.25	1	0.952380952	1	1	0.875
465_OG5_126864_1 - ALL (-ARCHAEA)_YCL035C	YCL035C	GRX1 - Hydroperoxide and superoxide-radical responsive heat-stable glutathione-dependent disulfide oxidoreductase with active site cysteine pair; protects cells from oxidative damage	1	0	0.472222222	0.875	0.904761905	1	0.95	0.8125
466_OG5_126864_1 - ALL (-ARCHAEA)_YDR513W	YDR513W	"GRX2 - Cytoplasmic glutaredoxin, thioltransferase, glutathione-dependent disulfide oxidoreductase involved in maintaining redox state of target proteins, also exhibits glutathione peroxidase activity, expression induced in response to stress"	1	0	0.472222222	0.875	0.904761905	1	0.95	0.8125
467_OG5_127360_1 - ALL (-ARCHAEA)_YFR031C	YFR031C	SMC2 - Subunit of the condensin complex; essential SMC chromosomal ATPase family member that forms a complex with Smc4p to form the active ATPase; Smc2p/Smc4p complex binds DNA; required for clustering of tRNA genes at the nucleolus	1	0.1875	0.333333333	1	0.857142857	1	1	0.9375
468_OG5_126873_1 - ALL (-ARCHAEA)_YJL155C	YJL155C	"FBP26 - Fructose-2,6-bisphosphatase, required for glucose metabolism"	1	0.0625	0.333333333	1	0.857142857	1	1	0.375
469_OG5_127574_1 - ALL (-ARCHAEA)_YEL024W	YEL024W	"RIP1 - Ubiquinol-cytochrome-c reductase, a Rieske iron-sulfur protein of the mitochondrial cytochrome bc1 complex; transfers electrons from ubiquinol to cytochrome c1 during respiration"	1	0	0.333333333	1	0.857142857	1	1	0.625
470_OG5_127417_1 - ALL (-ARCHAEA)_YML021C	YML021C	"UNG1 - Uracil-DNA glycosylase, required for repair of uracil in DNA formed by spontaneous cytosine deamination, not required for strand-specific mismatch repair, cell-cycle regulated, expressed in late G1, localizes to mitochondria and nucleus"	1	0	0.638888889	1	0.619047619	0.928571429	1	0.875
471_OG5_128029_1 - ALL (-ARCHAEA)_YNL071W	YNL071W	"LAT1 - Dihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase complex, which catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA"	1	0	0.277777778	1	0.904761905	1	1	0.3125
472_OG5_127363_1 - ALL (-ARCHAEA)_YBR037C	YBR037C	"SCO1 - Copper-binding protein of the mitochondrial inner membrane, required for cytochrome c oxidase activity and respiration; may function to deliver copper to cytochrome c oxidase; has similarity to thioredoxins"	1	0	0.388888889	1	0.857142857	0.928571429	1	0.6875
473_OG5_127363_1 - ALL (-ARCHAEA)_YBR024W	YBR024W	"SCO2 - Protein anchored to the mitochondrial inner membrane, similar to Sco1p and may have a redundant function with Sco1p in delivery of copper to cytochrome c oxidase; interacts with Cox2p"	1	0	0.388888889	1	0.857142857	0.928571429	1	0.6875
474_OG5_127555_1 - ALL (-ARCHAEA)_YER003C	YER003C	"PMI40 - Mannose-6-phosphate isomerase, catalyzes the interconversion of fructose-6-P and mannose-6-P; required for early steps in protein mannosylation"	1	0	0.222222222	1	0.952380952	1	1	0.6875
475_OG5_128503_1 - ALL (-ARCHAEA)_YHR144C	YHR144C	DCD1 - Deoxycytidine monophosphate (dCMP) deaminase required for dCTP and dTTP synthesis; expression is NOT cell cycle regulated	1	0.1875	0.361111111	1	0.80952381	1	1	0.3125
476_OG5_127394_1 - ALL (-ARCHAEA)_YEL029C	YEL029C	"BUD16 - Putative pyridoxal kinase, a key enzyme involved in pyridoxal 5'-phosphate synthesis, the active form of vitamin B6; required for genome integrity; involved in bud-site selection; similarity to yeast BUD17 and human pyridoxal kinase (PDXK)"	1	0	0.388888889	0.875	0.904761905	1	1	0.4375
477_OG5_127394_1 - ALL (-ARCHAEA)_YNR027W	YNR027W	"BUD17 - Putative pyridoxal kinase, a key enzyme in vitamin B6 metabolism; involved in bud-site selection; diploid mutants display a random rather than a bipolar budding pattern; similarity to yeast BUD16 and human pyridoxal kinase (PDXK)"	1	0	0.388888889	0.875	0.904761905	1	1	0.4375
478_OG5_127524_1 - ALL (-ARCHAEA)_YBR221C	YBR221C	"PDB1 - E1 beta subunit of the pyruvate dehydrogenase (PDH) complex, which is an evolutionarily-conserved multi-protein complex found in mitochondria"	1	0.125	0.333333333	1	0.904761905	0.928571429	1	0.5625
479_OG5_127257_1 - ALL (-ARCHAEA)_YDL168W	YDL168W	"SFA1 - Bifunctional enzyme containing both alcohol dehydrogenase and glutathione-dependent formaldehyde dehydrogenase activities, functions in formaldehyde detoxification and formation of long chain and complex alcohols, regulated by Hog1p-Sko1p"	1	0.1875	0.305555556	1	0.857142857	1	1	0.25
480_OG5_127836_1 - ALL (-ARCHAEA)_YDR036C	YDR036C	"EHD3 - 3-hydroxyisobutyryl-CoA hydrolase, member of a family of enoyl-CoA hydratase/isomerases; non-tagged protein is detected in highly purified mitochondria in high-throughput studies; phosphorylated; mutation affects fluid-phase endocytosis"	1	0.0625	0.25	1	0.904761905	1	1	0.375
481_OG5_126773_1 - ALL (-ARCHAEA)_YNL007C	YNL007C	SIS1 - Type II HSP40 co-chaperone that interacts with the HSP70 protein Ssa1p; not functionally redundant with Ydj1p due to due to substrate specificity; shares similarity with bacterial DnaJ proteins	1	0	0.25	1	0.904761905	1	1	0.875
482_OG5_127117_1 - ALL (-ARCHAEA)_YOR304W	YOR304W	"ISW2 - ATP-dependent DNA translocase involved in chromatin remodeling; ATPase component that, with Itc1p, forms a complex required for repression of a-specific genes, INO1, and early meiotic genes during mitotic growth"	1	0.0625	0.25	1	0.952380952	1	0.95	0.875
483_OG5_127117_1 - ALL (-ARCHAEA)_YBR245C	YBR245C	"ISW1 - Member of the imitation-switch (ISWI) class of ATP-dependent chromatin remodeling complexes; ATPase that forms a complex with Ioc2p and Ioc4p to regulate transcription elongation, and a complex with Ioc3p to repress transcription initiation"	1	0.0625	0.25	1	0.952380952	1	0.95	0.875
484_OG5_127509_1 - ALL (-ARCHAEA)_YOL008W	YOL008W	"COQ10 - Coenzyme Q (ubiquinone) binding protein, functions in the delivery of Q<sub>6</sub> to its proper location for electron transport during respiration; START domain protein with homologs in bacteria and eukaryotes"	1	0	0.416666667	1	0.857142857	0.928571429	0.95	0.625
485_OG5_127627_1 - ALL (-ARCHAEA)_YML004C	YML004C	"GLO1 - Monomeric glyoxalase I, catalyzes the detoxification of methylglyoxal (a by-product of glycolysis) via condensation with glutathione to produce S-D-lactoylglutathione; expression regulated by methylglyoxal levels and osmotic stress"	1	0.1875	0.527777778	1	0.619047619	1	1	0.3125
486_OG5_126753_1 - ALL (-ARCHAEA)_YKL029C	YKL029C	"MAE1 - Mitochondrial malic enzyme, catalyzes the oxidative decarboxylation of malate to pyruvate, which is a key intermediate in sugar metabolism and a precursor for synthesis of several amino acids"	1	0	0.361111111	1	0.857142857	0.928571429	1	0.5
487_OG5_128812_1 - ALL (-ARCHAEA)_YKR084C	YKR084C	"HBS1 - GTPase with similarity to translation release factors; together with binding partner Dom34p, facilitates ribosomal subunit dissociation and peptidyl-tRNA release when translation is stalled; genetically implicated in mRNA no-go decay"	1	0	0.333333333	1	0.80952381	1	1	0.1875
488_OG5_127523_1 - ALL (-ARCHAEA)_YKL040C	YKL040C	"NFU1 - Protein involved in iron metabolism in mitochondria; similar to NifU, which is a protein required for the maturation of the Fe/S clusters of nitrogenase in nitrogen-fixing bacteria"	1	0	0.333333333	1	0.857142857	1	0.95	0.75
489_OG5_126726_1 - ALL (-ARCHAEA)_YPL147W	YPL147W	"PXA1 - Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter and ALD-related proteins"	1	0	0.277777778	1	0.904761905	1	0.95	0.5
490_OG5_126726_1 - ALL (-ARCHAEA)_YKL188C	YKL188C	"PXA2 - Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter and ALD-related proteins"	1	0	0.277777778	1	0.904761905	1	0.95	0.5
491_OG5_126955_1 - ALL (-ARCHAEA)_YIL043C	YIL043C	"CBR1 - Microsomal cytochrome b reductase, not essential for viability; also detected in mitochondria; mutation in conserved NADH binding domain of the human ortholog results in type I methemoglobinemia"	1	0.0625	0.222222222	1	0.904761905	1	1	0.6875
492_OG5_128345_1 - ALL (-ARCHAEA)_YOR201C	YOR201C	"MRM1 - Ribose methyltransferase that modifies a functionally critical, conserved nucleotide in mitochondrial 21S rRNA"	1	0.0625	0.916666667	1	0.476190476	0.928571429	0.8	0.1875
493_OG5_126718_1 - ALL (-ARCHAEA)_YBR115C	YBR115C	"LYS2 - Alpha aminoadipate reductase, catalyzes the reduction of alpha-aminoadipate to alpha-aminoadipate 6-semialdehyde, which is the fifth step in biosynthesis of lysine; activation requires posttranslational phosphopantetheinylation by Lys5p"	1	0.0625	0.555555556	0.75	0.80952381	1	1	0.1875
494_OG5_127067_1 - ALL (-ARCHAEA)_YCL057W	YCL057W	"PRD1 - Zinc metalloendopeptidase, found in the cytoplasm and intermembrane space of mitochondria; with Cym1p, involved in degradation of mitochondrial proteins and of presequence peptides cleaved from imported proteins"	1	0	0.444444444	1	0.904761905	1	0.75	0.375
495_OG5_127680_1 - ALL (-ARCHAEA)_YNR036C	YNR036C	MRPS12 - Mitochondrial protein; may interact with ribosomes based on co-purification experiments; similar to E. coli and human mitochondrial S12 ribosomal proteins	1	0	0.972222222	0.5	0.761904762	0.857142857	1	0.4375
496_OG5_127515_1 - ALL (-ARCHAEA)_YLR239C	YLR239C	"LIP2 - Lipoyl ligase, involved in the modification of mitochondrial enzymes by the attachment of lipoic acid groups"	1	0	0.583333333	1	0.714285714	0.785714286	1	0.5
497_OG5_127073_1 - ALL (-ARCHAEA)_YBR177C	YBR177C	EHT1 - Acyl-coenzymeA:ethanol O-acyltransferase that plays a minor role in medium-chain fatty acid ethyl ester biosynthesis; possesses short-chain esterase activity; localizes to lipid particles and the mitochondrial outer membrane	1	0	0.277777778	1	0.904761905	1	0.9	0.375
498_OG5_127073_1 - ALL (-ARCHAEA)_YPL095C	YPL095C	EEB1 - Acyl-coenzymeA:ethanol O-acyltransferase responsible for the major part of medium-chain fatty acid ethyl ester biosynthesis during fermentation; possesses short-chain esterase activity; may be involved in lipid metabolism and detoxification	1	0	0.277777778	1	0.904761905	1	0.9	0.375
499_OG5_127073_1 - ALL (-ARCHAEA)_YMR210W	YMR210W	"YMR210W - Putative acyltransferase with similarity to Eeb1p and Eht1p, has a minor role in medium-chain fatty acid ethyl ester biosynthesis; may be involved in lipid metabolism and detoxification"	1	0	0.277777778	1	0.904761905	1	0.9	0.375
500_OG5_127021_1 - ALL (-ARCHAEA)_YLR299W	YLR299W	"ECM38 - Gamma-glutamyltranspeptidase, major glutathione-degrading enzyme; involved in detoxification of electrophilic xenobiotics; expression induced mainly by nitrogen starvation"	1	0.0625	0.388888889	0.875	0.80952381	1	1	0.1875
501_OG5_127571_1 - ALL (-ARCHAEA)_YPR073C	YPR073C	LTP1 - Protein phosphotyrosine phosphatase of unknown cellular role; activated by adenine	1	0	0.583333333	0.75	0.80952381	0.928571429	1	0.1875
502_OG5_127182_1 - ALL (-ARCHAEA)_YDR256C	YDR256C	"CTA1 - Catalase A, breaks down hydrogen peroxide in the peroxisomal matrix formed by acyl-CoA oxidase (Pox1p) during fatty acid beta-oxidation"	1	0	0.5	0.75	0.80952381	1	1	0.1875
503_OG5_127182_1 - ALL (-ARCHAEA)_YGR088W	YGR088W	"CTT1 - Cytosolic catalase T, has a role in protection from oxidative damage by hydrogen peroxide"	1	0	0.5	0.75	0.80952381	1	1	0.1875
504_OG5_127112_1 - ALL (-ARCHAEA)_YDR111C	YDR111C	ALT2 - Putative alanine transaminase (glutamic pyruvic transaminase)	1	0.1875	0.277777778	0.875	0.904761905	1	1	0.5625
505_OG5_127112_1 - ALL (-ARCHAEA)_YLR089C	YLR089C	"ALT1 - Alanine transaminase (glutamic pyruvic transaminase); involved in alanine biosynthetic and catabolic processes; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"	1	0.1875	0.277777778	0.875	0.904761905	1	1	0.5625
506_OG5_127501_1 - ALL (-ARCHAEA)_YGR248W	YGR248W	SOL4 - 6-phosphogluconolactonase with similarity to Sol3p	1	0	0.388888889	1	0.80952381	0.857142857	1	0.375
507_OG5_127501_1 - ALL (-ARCHAEA)_YHR163W	YHR163W	"SOL3 - 6-phosphogluconolactonase, catalyzes the second step of the pentose phosphate pathway; weak multicopy suppressor of los1-1 mutation; homologous to Sol2p and Sol1p"	1	0	0.388888889	1	0.80952381	0.857142857	1	0.375
508_OG5_127501_1 - ALL (-ARCHAEA)_YNR034W	YNR034W	"SOL1 - Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol2p, Sol3p, and Sol4p"	1	0	0.388888889	1	0.80952381	0.857142857	1	0.375
509_OG5_127501_1 - ALL (-ARCHAEA)_YCR073W-A	YCR073W-A	"SOL2 - Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol1p, Sol3p, and Sol4p"	1	0	0.388888889	1	0.80952381	0.857142857	1	0.375
510_OG5_126717_1 - ALL (-ARCHAEA)_YKR093W	YKR093W	"PTR2 - Integral membrane peptide transporter, mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p"	1	0	0.444444444	1	0.80952381	1	0.8	0.125
511_OG5_126994_1 - ALL (-ARCHAEA)_YPL252C	YPL252C	YAH1 - Ferredoxin of the mitochondrial matrix required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; homologous to human adrenodoxin	1	0	0.388888889	0.875	0.904761905	0.928571429	0.95	0.9375
512_OG5_126818_1 - ALL (-ARCHAEA)_Q0130	Q0130	"OLI1 - F0-ATP synthase subunit c (ATPase-associated proteolipid), encoded on the mitochondrial genome; mutation confers oligomycin resistance; expression is specifically dependent on the nuclear genes AEP1 and AEP2"	1	0	0.861111111	0.625	0.80952381	1	0.75	0.625
513_OG5_126650_1 - ALL (-ARCHAEA)_YPR003C	YPR003C	YPR003C - Putative sulfate permease; physically interacts with Hsp82p; green fluorescent protein (GFP)-fusion protein localizes to the ER; YPR003C is not an essential gene	1	0.0625	0.305555556	0.875	0.857142857	1	1	0.375
514_OG5_126650_1 - ALL (-ARCHAEA)_YBR294W	YBR294W	"SUL1 - High affinity sulfate permease of the SulP anion transporter family; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates"	1	0.0625	0.305555556	0.875	0.857142857	1	1	0.375
515_OG5_126650_1 - ALL (-ARCHAEA)_YLR092W	YLR092W	"SUL2 - High affinity sulfate permease; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates"	1	0.0625	0.305555556	0.875	0.857142857	1	1	0.375
516_OG5_127157_1 - ALL (-ARCHAEA)_YDR205W	YDR205W	"MSC2 - Member of the cation diffusion facilitator family, localizes to the endoplasmic reticulum and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids"	1	0.1875	0.666666667	0.5	0.904761905	1	0.95	0.4375
517_OG5_128372_1 - ALL (-ARCHAEA)_YDL120W	YDL120W	YFH1 - Mitochondrial matrix iron chaperone; oxidizes and stores iron; interacts with Isu1p to promote Fe-S cluster assembly; mutation results in multiple Fe/S-dependent enzyme deficiencies; human frataxin homolog is mutated in Friedrich's ataxia	1	0	0.305555556	1	0.857142857	0.857142857	1	0.5625
518_OG5_127245_1 - ALL (-ARCHAEA)_YNL141W	YNL141W	"AAH1 - Adenine deaminase (adenine aminohydrolase), converts adenine to hypoxanthine; involved in purine salvage; transcriptionally regulated by nutrient levels and growth phase; Aah1p degraded upon entry into quiescence via SCF and the proteasome"	1	0.0625	0.444444444	1	0.904761905	1	0.65	0.5
519_OG5_128402_1 - ALL (-ARCHAEA)_YGL018C	YGL018C	"JAC1 - Specialized J-protein that functions with Hsp70 in Fe-S cluster biogenesis in mitochondria, involved in iron metabolism; contains a J domain typical to J-type chaperones; localizes to the mitochondrial matrix"	1	0	0.333333333	1	0.714285714	1	0.95	0.625
520_OG5_128213_1 - ALL (-ARCHAEA)_YOR143C	YOR143C	"THI80 - Thiamine pyrophosphokinase, phosphorylates thiamine to produce the coenzyme thiamine pyrophosphate (thiamine diphosphate)"	1	0	0.361111111	1	0.857142857	0.928571429	0.85	0.4375
521_OG5_127283_1 - ALL (-ARCHAEA)_YAL044W-A	YAL044W-A	YAL044W-A - Putative protein of unknown function; similar to S. pombe uvi31 which is a putative DNA repair protein	1	0.125	0.527777778	1	0.857142857	0.642857143	0.95	0.375
522_OG5_127094_1 - ALL (-ARCHAEA)_YMR110C	YMR110C	"HFD1 - Putative fatty aldehyde dehydrogenase, located in the mitochondrial outer membrane and also in lipid particles; has similarity to human fatty aldehyde dehydrogenase (FALDH) which is implicated in Sjogren-Larsson syndrome"	1	0	0.361111111	0.75	0.952380952	1	0.9	0.3125
523_OG5_128032_1 - ALL (-ARCHAEA)_YFL053W	YFL053W	"DAK2 - Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation"	1	0.0625	0.333333333	1	0.666666667	0.928571429	1	0.1875
524_OG5_128032_1 - ALL (-ARCHAEA)_YML070W	YML070W	"DAK1 - Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation"	1	0.0625	0.333333333	1	0.666666667	0.928571429	1	0.1875
525_OG5_127389_1 - ALL (-ARCHAEA)_YCR028C-A	YCR028C-A	RIM1 - Single-stranded DNA-binding protein essential for mitochondrial genome maintenance; involved in mitochondrial DNA replication	1	0	1	0.625	0.666666667	0.785714286	0.85	0.1875
526_OG5_128744_1 - ALL (-ARCHAEA)_YGL125W	YGL125W	"MET13 - Major isozyme of methylenetetrahydrofolate reductase, catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate in the methionine biosynthesis pathway"	1	0	0.527777778	0.75	0.619047619	1	1	0.125
527_OG5_129182_1 - ALL (-ARCHAEA)_YJL068C	YJL068C	"YJL068C - Non-essential intracellular esterase that can function as an S-formylglutathione hydrolase; may be involved in the detoxification of formaldehyde, which can be metabolized to S-formylglutathione; similar to human esterase D"	1	0	0.25	0.875	0.80952381	1	0.95	0.0625
528_OG5_126939_1 - ALL (-ARCHAEA)_YGL055W	YGL055W	"OLE1 - Delta(9) fatty acid desaturase, required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria"	1	0	0.222222222	0.875	0.857142857	0.928571429	1	0.4375
529_OG5_128006_1 - ALL (-ARCHAEA)_YOR065W	YOR065W	"CYT1 - Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex"	1	0	0.25	1	0.904761905	0.714285714	1	0.625
530_OG5_127037_1 - ALL (-ARCHAEA)_YKL094W	YKL094W	"YJU3 - Monoglyceride lipase (MGL), functional ortholog of mammalian MGL, localizes to lipid particles and membranes, also member of the eukaryotic serine hydrolase family"	1	0.0625	0.527777778	1	0.428571429	1	0.9	0.375
531_OG5_128349_1 - ALL (-ARCHAEA)_YOL114C	YOL114C	YOL114C - Putative protein of unknown function with similarity to human ICT1 and prokaryotic factors that may function in translation termination; YOL114C is not an essential gene	1	0	0.361111111	0.875	0.857142857	0.857142857	0.9	0.4375
532_OG5_129066_1 - ALL (-ARCHAEA)_YER014W	YER014W	"HEM14 - Protoporphyrinogen oxidase, a mitochondrial enzyme that catalyzes the seventh step in the heme biosynthetic pathway, converting protoporphyrinogen IX to protoporphyrin IX; inhibited by diphenyl ether-type herbicides"	1	0.0625	0.277777778	1	0.714285714	0.857142857	1	0.125
533_OG5_129077_1 - ALL (-ARCHAEA)_YGL017W	YGL017W	"ATE1 - Arginyl-tRNA-protein transferase, catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway"	1	0	0.25	0.875	0.857142857	0.857142857	1	0.0625
534_OG5_129087_1 - ALL (-ARCHAEA)_YLR059C	YLR059C	"REX2 - 3'-5' RNA exonuclease; involved in 3'-end processing of U4 and U5 snRNAs, 5S and 5.8S rRNAs, and RNase P and RNase MRP RNA; localized to mitochondria and null suppresses escape of mtDNA to nucleus in yme1 yme2 mutants; RNase D exonuclease"	1	0	0.361111111	0.75	0.80952381	1	0.9	0.125
535_OG5_128045_1 - ALL (-ARCHAEA)_YBR187W	YBR187W	GDT1 - Putative protein of unknown function; expression is reduced in a gcr1 null mutant; GFP-fusion protein localizes to the vacuole; expression pattern and physical interactions suggest a possible role in ribosome biogenesis	1	0.1875	0.222222222	1	0.80952381	0.785714286	1	0.4375
536_OG5_127477_1 - ALL (-ARCHAEA)_YPL264C	YPL264C	YPL264C - Putative membrane protein of unknown function; physically interacts with Hsp82p; YPL264C is not an essential gene	1	0	0.416666667	0.875	0.666666667	1	0.85	0.0625
537_OG5_127477_1 - ALL (-ARCHAEA)_YMR253C	YMR253C	YMR253C - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YMR253C is not an essential gene	1	0	0.416666667	0.875	0.666666667	1	0.85	0.0625
538_OG5_127953_1 - ALL (-ARCHAEA)_YJR117W	YJR117W	"STE24 - Highly conserved zinc metalloprotease that functions in two steps of a-factor maturation, C-terminal CAAX proteolysis and the first step of N-terminal proteolytic processing; contains multiple transmembrane spans"	1	0.125	0.277777778	0.625	0.904761905	1	1	0.875
539_OG5_128404_1 - ALL (-ARCHAEA)_YGL067W	YGL067W	"NPY1 - NADH diphosphatase (pyrophosphatase), hydrolyzes the pyrophosphate linkage in NADH and related nucleotides; localizes to peroxisomes"	1	0	0.472222222	1	0.380952381	1	0.95	0.125
540_OG5_128904_1 - ALL (-ARCHAEA)_YPL222W	YPL222W	"FMP40 - Putative protein of unknown function; proposed to be involved in responding to environmental stresses; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"	1	0.0625	0.416666667	1	0.380952381	1	1	0.125
541_OG5_127584_1 - ALL (-ARCHAEA)_YJR104C	YJR104C	SOD1 - Cytosolic copper-zinc superoxide dismutase; some mutations are analogous to those that cause ALS (amyotrophic lateral sclerosis) in humans	1	0	0.472222222	0.75	0.714285714	0.857142857	1	0.125
542_OG5_127264_1 - ALL (-ARCHAEA)_YNR029C	YNR029C	"YNR029C - Putative protein of unknown function, deletion confers reduced fitness in saline"	1	0.0625	0.388888889	1	0.476190476	0.928571429	1	0.6875
543_OG5_128934_1 - ALL (-ARCHAEA)_YDR109C	YDR109C	YDR109C - Putative kinase	1	0	0.277777778	1	0.619047619	0.928571429	0.95	0.125
544_OG5_127317_1 - ALL (-ARCHAEA)_YMR152W	YMR152W	"YIM1 - Protein of unknown function; null mutant displays sensitivity to DNA damaging agents; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"	1	0	0.25	0.75	0.857142857	1	0.9	0.125
545_OG5_127610_1 - ALL (-ARCHAEA)_YKR088C	YKR088C	TVP38 - Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; required for asymmetric localization of Kar9p during mitosis; GFP-fusion protein localizes to the cytoplasm in a punctate pattern	1	0.0625	0.25	1	0.666666667	0.928571429	0.9	0.5
546_OG5_127915_1 - ALL (-ARCHAEA)_YLR109W	YLR109W	"AHP1 - Thiol-specific peroxiredoxin, reduces hydroperoxides to protect against oxidative damage; function in vivo requires covalent conjugation to Urm1p"	1	0	0.25	1	0.666666667	0.785714286	1	0.1875
547_OG5_127342_1 - ALL (-ARCHAEA)_YFR044C	YFR044C	DUG1 - Cys-Gly metallo-di-peptidase; forms a complex with Dug2p and Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p)	1	0.1875	0.333333333	0.5	0.857142857	1	1	0.3125
548_OG5_128271_1 - ALL (-ARCHAEA)_YML059C	YML059C	"NTE1 - Serine esterase, homolog of human neuropathy target esterase (NTE); Nte1p-mediated phosphatidylcholine turnover influences transcription factor Opi1p localization, affecting transcriptional regulation of phospholipid biosynthesis genes"	1	0	0.472222222	0.5	0.714285714	1	1	0.1875
549_OG5_127267_1 - ALL (-ARCHAEA)_YMR226C	YMR226C	"YMR226C - NADP(+)-dependent dehydrogenase; acts on serine, L-allo-threonine, and other 3-hydroxy acids; green fluorescent protein fusion protein localizes to the cytoplasm and nucleus; may interact with ribosomes, based on co-purification experiments"	1	0.1875	0.666666667	0.375	0.619047619	1	1	0.125
550_OG5_128449_1 - ALL (-ARCHAEA)_YMR097C	YMR097C	"MTG1 - Putative GTPase peripheral to the mitochondrial inner membrane, essential for respiratory competence, likely functions in assembly of the large ribosomal subunit, has homologs in plants and animals"	1	0	0.277777778	0.75	0.761904762	0.857142857	1	0.6875
551_OG5_127001_1 - ALL (-ARCHAEA)_YDR400W	YDR400W	"URH1 - Uridine nucleosidase (uridine-cytidine N-ribohydrolase), cleaves N-glycosidic bonds in nucleosides; involved in the pyrimidine salvage and nicotinamide riboside salvage pathways"	1	0.1875	0.444444444	1	0.80952381	0.357142857	1	0.375
552_OG5_127436_1 - ALL (-ARCHAEA)_YMR234W	YMR234W	RNH1 - Ribonuclease H1; able to bind double-stranded RNAs and RNA-DNA hybrids; associates with RNAse polymerase I; the homolog of mammalian RNAse HII (the S. cerevisiae homolog of mammalian RNAse HI is RNH201)	1	0.0625	0.75	0.25	0.666666667	0.928571429	1	0.5625
553_OG5_128811_1 - ALL (-ARCHAEA)_YGL001C	YGL001C	"ERG26 - C-3 sterol dehydrogenase, catalyzes the second of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis"	1	0	0.277777778	1	0.380952381	0.928571429	1	0.1875
554_OG5_128944_1 - ALL (-ARCHAEA)_YPL183W-A	YPL183W-A	"RTC6 - Protein involved translation; mutants have defects in biogenesis of nuclear ribosomes; sequence similar to prokaryotic ribosomal protein L36, may be a mitochondrial ribosomal protein encoded in the nucleus"	1	0	0.75	0.625	0.619047619	0.785714286	0.8	0.25
555_OG5_128639_1 - ALL (-ARCHAEA)_YEL046C	YEL046C	"GLY1 - Threonine aldolase, catalyzes the cleavage of L-allo-threonine and L-threonine to glycine; involved in glycine biosynthesis"	1	0.0625	0.333333333	1	0.714285714	0.5	1	0.0625
556_OG5_126827_1 - ALL (-ARCHAEA)_YGR292W	YGR292W	"MAL12 - Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL1 complex locus; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose"	1	0.0625	0.638888889	0.375	0.761904762	1	0.75	0.0625
557_OG5_126827_1 - ALL (-ARCHAEA)_YJL216C	YJL216C	"IMA5 - Alpha-glucosidase with specificity for isomaltose, maltose, and palatinose; member of the IMA isomaltase family; not required for isomaltose utilization, but Ima5p overexpression allows the ima1 null mutant to grow on isomaltose"	1	0.0625	0.638888889	0.375	0.761904762	1	0.75	0.0625
558_OG5_126827_1 - ALL (-ARCHAEA)_YGR287C	YGR287C	"IMA1 - Major isomaltase (alpha-1,6-glucosidase) required for isomaltose utilization; has specificity for isomaltose, palatinose, and methyl-alpha-glucoside; member of the IMA isomaltase family"	1	0.0625	0.638888889	0.375	0.761904762	1	0.75	0.0625
559_OG5_126827_1 - ALL (-ARCHAEA)_YBR299W	YBR299W	"MAL32 - Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL3 complex locus; functional in genomic reference strain S288C; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose"	1	0.0625	0.638888889	0.375	0.761904762	1	0.75	0.0625
560_OG5_126827_1 - ALL (-ARCHAEA)_YIL172C	YIL172C	"IMA3 - Alpha-glucosidase with broad substrate specificity for alpha-1,4- and alpha-1,6-glucosides; member of IMA isomaltase family; not required for isomaltose utilization, but Ima3p overexpression allows the ima1 null mutant to grow on isomaltose"	1	0.0625	0.638888889	0.375	0.761904762	1	0.75	0.0625
561_OG5_126827_1 - ALL (-ARCHAEA)_YJL221C	YJL221C	"IMA4 - Alpha-glucosidase with broad substrate specificity for alpha-1,4- and alpha-1,6-glucosides; member of IMA isomaltase family; not required for isomaltose utilization, but Ima4p overexpression allows the ima1 null mutant to grow on isomaltose"	1	0.0625	0.638888889	0.375	0.761904762	1	0.75	0.0625
562_OG5_126827_1 - ALL (-ARCHAEA)_YOL157C	YOL157C	"IMA2 - Alpha-glucosidase with specificity for isomaltase, methyl-alpha-glucoside, and palatinose; member of IMA isomaltase family; not required for isomaltose utilization, but Ima2p overexpression allows the ima1 null mutant to grow on isomaltose"	1	0.0625	0.638888889	0.375	0.761904762	1	0.75	0.0625
563_OG5_129357_1 - ALL (-ARCHAEA)_YMR114C	YMR114C	"YMR114C - Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR114C is not an essential gene"	1	0.125	0.222222222	0.875	0.666666667	1	0.75	0.25
564_OG5_127837_1 - ALL (-ARCHAEA)_YHR210C	YHR210C	YHR210C - Putative protein of unknown function; non-essential gene; highly expressed under anaeorbic conditions; sequence similarity to aldose 1-epimerases such as GAL10	1	0	0.361111111	1	0.80952381	0.785714286	0.55	0.25
565_OG5_127837_1 - ALL (-ARCHAEA)_YNR071C	YNR071C	YNR071C - Putative protein of unknown function	1	0	0.361111111	1	0.80952381	0.785714286	0.55	0.25
566_OG5_128903_1 - ALL (-ARCHAEA)_Q0085	Q0085	ATP6 - Mitochondrially encoded subunit a of the F0 sector of mitochondrial F1F0 ATP synthase; translation is specifically activated by Atp22p; ATP6 and ATP8 mRNAs are not translated in the absence of the F1 sector of ATPase	1	0	0.916666667	0.75	0.380952381	0.857142857	0.6	0
567_OG5_127613_1 - ALL (-ARCHAEA)_YMR278W	YMR278W	"PGM3 - Phosphoglucomutase, catalyzes interconversion of glucose-1-phosphate and glucose-6-phospate; transcription induced in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; non-essential"	1	0.0625	0.416666667	0.375	0.904761905	1	0.8	0.625
568_OG5_128411_1 - ALL (-ARCHAEA)_YPL109C	YPL109C	"YPL109C - Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"	1	0	0.25	1	0.380952381	0.857142857	1	0.25
569_OG5_129150_1 - ALL (-ARCHAEA)_YDR115W	YDR115W	"YDR115W - Putative mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L34 ribosomal protein; required for respiratory growth, as are most mitochondrial ribosomal proteins"	1	0	0.888888889	0.625	0.333333333	0.714285714	0.9	0.0625
570_OG5_128626_1 - ALL (-ARCHAEA)_YER050C	YER050C	"RSM18 - Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein"	1	0	1	0.25	0.666666667	0.785714286	0.75	0.125
571_OG5_127410_1 - ALL (-ARCHAEA)_YDL078C	YDL078C	"MDH3 - Peroxisomal malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the glyoxylate cycle"	1	0	0.222222222	1	0.952380952	1	0.25	0.4375
572_OG5_128067_1 - ALL (-ARCHAEA)_YNL218W	YNL218W	MGS1 - Protein with DNA-dependent ATPase and ssDNA annealing activities involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP)	1	0	0.805555556	0.375	0.428571429	0.857142857	0.95	0.3125
573_OG5_127214_1 - ALL (-ARCHAEA)_YML131W	YML131W	"YML131W - Putative protein of unknown function with similarity to medium chain dehydrogenase/reductases; expression induced by stresses including osmotic shock, DNA damaging agents, and other chemicals; GFP-fusion protein localizes to the cytoplasm"	1	0.0625	0.25	0.5	0.714285714	1	0.95	0
574_OG5_129227_1 - ALL (-ARCHAEA)_YBR018C	YBR018C	"GAL7 - Galactose-1-phosphate uridyl transferase, synthesizes glucose-1-phosphate and UDP-galactose from UDP-D-glucose and alpha-D-galactose-1-phosphate in the second step of galactose catabolism"	1	0.1875	0.305555556	0.5	0.714285714	0.928571429	0.9	0.0625
575_OG5_127491_1 - ALL (-ARCHAEA)_YKL152C	YKL152C	"GPM1 - Tetrameric phosphoglycerate mutase, mediates the conversion of 3-phosphoglycerate to 2-phosphoglycerate during glycolysis and the reverse reaction during gluconeogenesis"	1	0	0.527777778	0.75	0.571428571	1	0.45	0.5625
576_OG5_128465_1 - ALL (-ARCHAEA)_YHR029C	YHR029C	"YHI9 - Protein of unknown function; null mutant is defective in unfolded protein response; possibly involved in a membrane regulation metabolic pathway; member of the PhzF superfamily, though most likely not involved in phenazine production"	1	0.125	0.416666667	0.875	0.285714286	0.857142857	0.85	0.1875
577_OG5_129981_1 - ALL (-ARCHAEA)_YMR034C	YMR034C	"YMR034C - Putative transporter, member of the SLC10 carrier family; identified in a transposon mutagenesis screen as a gene involved in azole resistance; YMR034C is not an essential gene"	1	0	0.333333333	0.875	0.238095238	1	0.8	0
578_OG5_130204_1 - ALL (-ARCHAEA)_YKR087C	YKR087C	"OMA1 - Metalloendopeptidase of the mitochondrial inner membrane, involved in turnover of membrane-embedded proteins; member of a family of predicted membrane-bound metallopeptidases in prokaryotes and higher eukaryotes"	1	0.0625	0.222222222	0.875	0.476190476	0.857142857	0.8	0.0625
579_OG5_129347_1 - ALL (-ARCHAEA)_YDR248C	YDR248C	"YDR248C - Putative protein of unknown function; sequence similarity to bacterial and human gluconokinase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; upregulated by deletion of the RNAP-II associated factor, PAF1"	1	0	0.305555556	0.75	0.285714286	0.857142857	1	0.1875
580_OG5_129957_1 - ALL (-ARCHAEA)_YML009C	YML009C	MRPL39 - Mitochondrial ribosomal protein of the large subunit	1	0	0.527777778	1	0.238095238	0.642857143	0.75	0.0625
581_OG5_128583_1 - ALL (-ARCHAEA)_Q0275	Q0275	"COX3 - Subunit III of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; one of three mitochondrially-encoded subunits"	1	0.125	0.638888889	0.625	0.476190476	0.857142857	0.55	0.3125
582_OG5_126942_1 - ALL (-ARCHAEA)_YNL229C	YNL229C	URE2 - Nitrogen catabolite repression transcriptional regulator that acts by inhibition of GLN3 transcription in good nitrogen source; has glutathione peroxidase activity and can mutate to acquire GST activity; altered form creates [URE3] prion	1	0	0.361111111	1	0.571428571	0.214285714	1	0
583_OG5_126860_1 - ALL (-ARCHAEA)_YKL071W	YKL071W	"YKL071W - Putative protein of unknown function; expression induced in cells treated with the mycotoxin patulin, and also the quinone methide triterpene celastrol; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm"	1	0.0625	0.305555556	1	0.666666667	0.357142857	0.65	0.125
584_OG5_129406_1 - ALL (-ARCHAEA)_YER004W	YER004W	"FMP52 - Protein of unknown function, localized to the mitochondrial outer membrane; induced by treatment with 8-methoxypsoralen and UVA irradiation"	1	0	0.222222222	0.5	0.333333333	0.928571429	0.9	0.3125
585_OG5_128466_1 - ALL (-ARCHAEA)_YPL103C	YPL103C	FMP30 - Mitochondrial inner membrane protein with a role in maintaining mitochondrial morphology and normal cardiolipin levels; proposed to be involved in N-acylethanolamine metabolism; related to mammalian N-acylPE-specific phospholipase D	1	0.0625	0.25	0.25	0.380952381	0.928571429	0.95	0.5
586_OG5_130009_1 - ALL (-ARCHAEA)_YNL117W	YNL117W	"MLS1 - Malate synthase, enzyme of the glyoxylate cycle, involved in utilization of non-fermentable carbon sources; expression is subject to carbon catabolite repression; localizes in peroxisomes during growth in oleic acid medium"	1	0.125	0.277777778	0.625	0.476190476	0.357142857	0.95	0.0625
587_OG5_130009_1 - ALL (-ARCHAEA)_YIR031C	YIR031C	"DAL7 - Malate synthase, role in allantoin degradation unknown; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation"	1	0.125	0.277777778	0.625	0.476190476	0.357142857	0.95	0.0625
588_OG5_126923_2 - ALL (-BACTERIA)_YDR385W	YDR385W	"EFT2 - Elongation factor 2 (EF-2), also encoded by EFT1; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin"	1	1	0.027777778	1	1	1	1	1
589_OG5_126923_2 - ALL (-BACTERIA)_YOR133W	YOR133W	"EFT1 - Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin"	1	1	0.027777778	1	1	1	1	1
590_OG5_126926_2 - ALL (-BACTERIA)_YDL126C	YDL126C	"CDC48 - ATPase involved in ubiquitin-mediated protein degradation; Cdc48p-Npl4p-Ufd1p complex participates in ER-associated degradation (ERAD) while Cdc48p-Npl4p-Vms1p complex participates in mitochondria-associated degradation (MAD); along with Npl4-Ufd1 complex, important for maintaining the cell wall integrity during heat stress to allow G1 progression"	1	1	0.027777778	1	1	1	1	1
591_OG5_127250_2 - ALL (-BACTERIA)_YBR143C	YBR143C	SUP45 - Polypeptide release factor (eRF1) in translation termination; mutant form acts as a recessive omnipotent suppressor; methylated by Mtq2p-Trm112p in ternary complex eRF1-eRF3-GTP; mutation of methylation site confers resistance to zymocin	1	1	0.027777778	1	1	1	1	1
592_OG5_126766_2 - ALL (-BACTERIA)_YBR191W	YBR191W	"RPL21A - Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl21Bp and has similarity to rat L21 ribosomal protein"	1	1	0	1	1	1	1	0.9375
593_OG5_126766_2 - ALL (-BACTERIA)_YPL079W	YPL079W	"RPL21B - Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl21Ap and has similarity to rat L21 ribosomal protein"	1	1	0	1	1	1	1	0.9375
594_OG5_126852_2 - ALL (-BACTERIA)_YML063W	YML063W	RPS1B - Ribosomal protein 10 (rp10) of the small (40S) subunit; nearly identical to Rps1Ap and has similarity to rat S3a ribosomal protein	1	1	0	1	1	1	1	0.9375
595_OG5_126852_2 - ALL (-BACTERIA)_YLR441C	YLR441C	RPS1A - Ribosomal protein 10 (rp10) of the small (40S) subunit; nearly identical to Rps1Bp and has similarity to rat S3a ribosomal protein	1	1	0	1	1	1	1	0.9375
596_OG5_126900_2 - ALL (-BACTERIA)_YJL177W	YJL177W	"RPL17B - Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl17Ap and has similarity to E. coli L22 and rat L17 ribosomal proteins"	1	1	0	1	1	1	1	1
597_OG5_126900_2 - ALL (-BACTERIA)_YKL180W	YKL180W	"RPL17A - Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl17Bp and has similarity to E. coli L22 and rat L17 ribosomal proteins; copurifies with the Dam1 complex (aka DASH complex)"	1	1	0	1	1	1	1	1
598_OG5_126912_2 - ALL (-BACTERIA)_YER148W	YER148W	"SPT15 - TATA-binding protein, general transcription factor that interacts with other factors to form the preinitiation complex at promoters, essential for viability"	1	1	0	1	1	1	1	1
599_OG5_126931_2 - ALL (-BACTERIA)_YGR034W	YGR034W	"RPL26B - Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl26Ap and has similarity to E. coli L24 and rat L26 ribosomal proteins; binds to 5.8S rRNA"	1	1	0	1	1	1	1	0.9375
600_OG5_126931_2 - ALL (-BACTERIA)_YLR344W	YLR344W	"RPL26A - Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl26Bp and has similarity to E. coli L24 and rat L26 ribosomal proteins; binds to 5.8S rRNA"	1	1	0	1	1	1	1	0.9375
601_OG5_126940_2 - ALL (-BACTERIA)_YBL027W	YBL027W	"RPL19B - Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl19Ap and has similarity to rat L19 ribosomal protein; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal"	1	1	0	1	1	1	1	0.9375
602_OG5_126940_2 - ALL (-BACTERIA)_YBR084C-A	YBR084C-A	"RPL19A - Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl19Bp and has similarity to rat L19 ribosomal protein; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal"	1	1	0	1	1	1	1	0.9375
603_OG5_126953_2 - ALL (-BACTERIA)_YGL076C	YGL076C	"RPL7A - Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl7Bp and has similarity to E. coli L30 and rat L7 ribosomal proteins; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2)"	1	1	0	1	1	1	1	0.9375
604_OG5_126953_2 - ALL (-BACTERIA)_YPL198W	YPL198W	"RPL7B - Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl7Ap and has similarity to E. coli L30 and rat L7 ribosomal proteins; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2)"	1	1	0	1	1	1	1	0.9375
605_OG5_126964_2 - ALL (-BACTERIA)_YBR181C	YBR181C	RPS6B - Protein component of the small (40S) ribosomal subunit; identical to Rps6Ap and has similarity to rat S6 ribosomal protein	1	1	0	1	1	1	1	1
606_OG5_126964_2 - ALL (-BACTERIA)_YPL090C	YPL090C	RPS6A - Protein component of the small (40S) ribosomal subunit; identical to Rps6Bp and has similarity to rat S6 ribosomal protein	1	1	0	1	1	1	1	1
607_OG5_126993_2 - ALL (-BACTERIA)_YGL147C	YGL147C	"RPL9A - Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl9Bp and has similarity to E. coli L6 and rat L9 ribosomal proteins"	1	1	0	1	1	1	1	1
608_OG5_126993_2 - ALL (-BACTERIA)_YNL067W	YNL067W	"RPL9B - Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl9Ap and has similarity to E. coli L6 and rat L9 ribosomal proteins"	1	1	0	1	1	1	1	1
609_OG5_127033_2 - ALL (-BACTERIA)_YMR121C	YMR121C	"RPL15B - Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl15Ap and has similarity to rat L15 ribosomal protein; binds to 5.8 S rRNA"	1	1	0	1	1	1	1	0.9375
610_OG5_127033_2 - ALL (-BACTERIA)_YLR029C	YLR029C	"RPL15A - Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl15Bp and has similarity to rat L15 ribosomal protein; binds to 5.8 S rRNA"	1	1	0	1	1	1	1	0.9375
611_OG5_127050_2 - ALL (-BACTERIA)_YBR031W	YBR031W	"RPL4A - N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl4Bp and has similarity to E. coli L4 and rat L4 ribosomal proteins"	1	1	0	1	1	1	1	0.9375
612_OG5_127050_2 - ALL (-BACTERIA)_YDR012W	YDR012W	"RPL4B - Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl4Ap and has similarity to E. coli L4 and rat L4 ribosomal proteins"	1	1	0	1	1	1	1	0.9375
613_OG5_127051_2 - ALL (-BACTERIA)_YLR340W	YLR340W	"RPP0 - Conserved ribosomal protein P0 of the ribosomal stalk, which is involved in interaction between translational elongation factors and the ribosome; similar to rat P0, human P0, and E. coli L10e; phosphorylated on serine 302"	1	1	0	1	1	1	1	1
614_OG5_127090_2 - ALL (-BACTERIA)_YPL131W	YPL131W	RPL5 - Protein component of the large (60S) ribosomal subunit with similarity to E. coli L18 and rat L5 ribosomal proteins; binds 5S rRNA and is required for 60S subunit assembly	1	1	0	1	1	1	1	1
615_OG5_127114_2 - ALL (-BACTERIA)_YPL220W	YPL220W	"RPL1A - N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl1Bp and has similarity to E. coli L1 and rat L10a ribosomal proteins; rpl1a rpl1b double null mutation is lethal"	1	1	0	1	1	1	1	0.9375
616_OG5_127114_2 - ALL (-BACTERIA)_YGL135W	YGL135W	"RPL1B - N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl1Ap and has similarity to E. coli L1 and rat L10a ribosomal proteins; rpl1a rpl1b double null mutation is lethal"	1	1	0	1	1	1	1	0.9375
617_OG5_127127_2 - ALL (-BACTERIA)_YMR260C	YMR260C	"TIF11 - Translation initiation factor eIF1A, essential protein that forms a complex with Sui1p (eIF1) and the 40S ribosomal subunit and scans for the start codon; C-terminus associates with Fun12p (eIF5B); N terminus interacts with eIF2 and eIF3"	1	1	0	1	1	1	1	1
618_OG5_127288_2 - ALL (-BACTERIA)_YPR086W	YPR086W	"SUA7 - Transcription factor TFIIB, a general transcription factor required for transcription initiation and start site selection by RNA polymerase II"	1	1	0	1	1	1	1	0.75
619_OG5_127301_2 - ALL (-BACTERIA)_YEL051W	YEL051W	"VMA8 - Subunit D of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; plays a role in the coupling of proton transport and ATP hydrolysis"	1	1	0.138888889	1	0.952380952	1	1	1
620_OG5_127227_2 - ALL (-BACTERIA)_YLL018C	YLL018C	"DPS1 - Aspartyl-tRNA synthetase, primarily cytoplasmic; homodimeric enzyme that catalyzes the specific aspartylation of tRNA(Asp); class II aminoacyl tRNA synthetase; binding to its own mRNA may confer autoregulation"	1	1	0.111111111	1	0.952380952	1	1	0.9375
621_OG5_127405_2 - ALL (-BACTERIA)_YOR243C	YOR243C	"PUS7 - Pseudouridine synthase, catalyzes pseudouridylation at positions 35 and 56 in U2 snRNA, position 50 in 5S rRNA, position 13 in cytoplasmic tRNAs, and position 35 in pre-tRNA(Tyr); conserved in archaea, vertebrates, and some bacteria"	1	1	0.055555556	1	0.952380952	1	1	0.875
622_OG5_127490_2 - ALL (-BACTERIA)_YLR060W	YLR060W	"FRS1 - Beta subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs2p to generate active enzyme; able to hydrolyze mis-aminoacylated tRNA-Phe, which could contribute to translational quality control"	1	1	0.027777778	1	0.952380952	1	1	0.9375
623_OG5_126694_2 - ALL (-BACTERIA)_YOR151C	YOR151C	"RPB2 - RNA polymerase II second largest subunit B150, part of central core; similar to bacterial beta subunit"	1	1	0	1	0.952380952	1	1	0.9375
624_OG5_126694_2 - ALL (-BACTERIA)_YOR207C	YOR207C	"RET1 - Second-largest subunit of RNA polymerase III, which is responsible for the transcription of tRNA and 5S RNA genes, and other low molecular weight RNAs"	1	1	0	1	0.952380952	1	1	0.9375
625_OG5_126874_2 - ALL (-BACTERIA)_YOR063W	YOR063W	"RPL3 - Protein component of the large (60S) ribosomal subunit, has similarity to E. coli L3 and rat L3 ribosomal proteins; involved in the replication and maintenance of killer double stranded RNA virus"	1	1	0	1	0.952380952	1	1	1
626_OG5_126890_2 - ALL (-BACTERIA)_YJR145C	YJR145C	RPS4A - Protein component of the small (40S) ribosomal subunit; mutation affects 20S pre-rRNA processing; identical to Rps4Bp and has similarity to rat S4 ribosomal protein	1	1	0	1	0.952380952	1	1	0.9375
627_OG5_126890_2 - ALL (-BACTERIA)_YHR203C	YHR203C	RPS4B - Protein component of the small (40S) ribosomal subunit; identical to Rps4Ap and has similarity to rat S4 ribosomal protein	1	1	0	1	0.952380952	1	1	0.9375
628_OG5_127016_2 - ALL (-BACTERIA)_YGL103W	YGL103W	"RPL28 - Ribosomal protein of the large (60S) ribosomal subunit, has similarity to E. coli L15 and rat L27a ribosomal proteins; may have peptidyl transferase activity; can mutate to cycloheximide resistance"	1	1	0	1	0.952380952	1	1	0.9375
629_OG5_127096_2 - ALL (-BACTERIA)_YOL097C	YOL097C	"WRS1 - Cytoplasmic tryptophanyl-tRNA synthetase, aminoacylates tryptophanyl-tRNA"	1	1	0	1	0.952380952	1	1	1
630_OG5_127102_2 - ALL (-BACTERIA)_YLR378C	YLR378C	"SEC61 - Essential subunit of Sec61 complex (Sec61p, Sbh1p, and Sss1p); forms a channel for SRP-dependent protein import and retrograde transport of misfolded proteins out of the ER; with Sec63 complex allows SRP-independent protein import into ER"	1	1	0	1	0.952380952	1	1	0.9375
631_OG5_127231_2 - ALL (-BACTERIA)_YBL091C	YBL091C	"MAP2 - Methionine aminopeptidase, catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map1p"	1	1	0	1	0.952380952	1	1	0.9375
632_OG5_127339_2 - ALL (-BACTERIA)_YPL237W	YPL237W	"SUI3 - Beta subunit of the translation initiation factor eIF2, involved in the identification of the start codon; proposed to be involved in mRNA binding"	1	1	0	1	0.952380952	1	1	1
633_OG5_127367_2 - ALL (-BACTERIA)_YLR022C	YLR022C	SDO1 - Essential protein involved in 60S ribosome maturation; ortholog of the human protein (SBDS) responsible for autosomal recessive Shwachman-Bodian-Diamond Syndrome; highly conserved across archae and eukaryotes	1	1	0	1	0.952380952	1	1	1
634_OG5_127465_2 - ALL (-BACTERIA)_YOR217W	YOR217W	"RFC1 - Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon"	1	1	0	1	0.952380952	1	1	0.9375
635_OG5_126878_2 - ALL (-BACTERIA)_YJL190C	YJL190C	RPS22A - Protein component of the small (40S) ribosomal subunit; nearly identical to Rps22Bp and has similarity to E. coli S8 and rat S15a ribosomal proteins	1	1	0.055555556	1	1	1	0.95	1
636_OG5_126878_2 - ALL (-BACTERIA)_YLR367W	YLR367W	RPS22B - Protein component of the small (40S) ribosomal subunit; nearly identical to Rps22Ap and has similarity to E. coli S8 and rat S15a ribosomal proteins	1	1	0.055555556	1	1	1	0.95	1
637_OG5_127166_2 - ALL (-BACTERIA)_YPR043W	YPR043W	"RPL43A - Protein component of the large (60S) ribosomal subunit, identical to Rpl43Bp and has similarity to rat L37a ribosomal protein; null mutation confers a dominant lethal phenotype"	1	1	0	1	1	1	0.95	0.875
638_OG5_127166_2 - ALL (-BACTERIA)_YJR094W-A	YJR094W-A	"RPL43B - Protein component of the large (60S) ribosomal subunit, identical to Rpl43Ap and has similarity to rat L37a ribosomal protein"	1	1	0	1	1	1	0.95	0.875
639_OG5_127411_2 - ALL (-BACTERIA)_YPL093W	YPL093W	NOG1 - Putative GTPase that associates with free 60S ribosomal subunits in the nucleolus and is required for 60S ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; member of the ODN family of nucleolar G-proteins	1	0.9375	0	1	1	1	1	1
640_OG5_126922_2 - ALL (-BACTERIA)_YJR047C	YJR047C	"ANB1 - Translation elongation factor eIF-5A, previously thought to function in translation initiation; similar to and functionally redundant with Hyp2p; undergoes an essential hypusination modification; expressed under anaerobic conditions"	1	1	0	1	1	0.928571429	1	0.875
641_OG5_126922_2 - ALL (-BACTERIA)_YEL034W	YEL034W	HYP2 - Translation elongation factor eIF-5A that may function in translation initiation; similar to and functionally redundant with Anb1p; structural homolog of bacterial EF-P; undergoes an essential hypusination modification	1	1	0	1	1	0.928571429	1	0.875
642_OG5_126930_2 - ALL (-BACTERIA)_YMR143W	YMR143W	RPS16A - Protein component of the small (40S) ribosomal subunit; identical to Rps16Bp and has similarity to E. coli S9 and rat S16 ribosomal proteins	1	1	0	1	1	0.928571429	1	1
643_OG5_126930_2 - ALL (-BACTERIA)_YDL083C	YDL083C	RPS16B - Protein component of the small (40S) ribosomal subunit; identical to Rps16Ap and has similarity to E. coli S9 and rat S16 ribosomal proteins	1	1	0	1	1	0.928571429	1	1
644_OG5_126951_2 - ALL (-BACTERIA)_YLR075W	YLR075W	"RPL10 - Protein component of the large (60S) ribosomal subunit, responsible for joining the 40S and 60S subunits; regulates translation initiation; has similarity to rat L10 ribosomal protein and to members of the QM gene family"	1	1	0	1	1	0.928571429	1	1
645_OG5_126965_2 - ALL (-BACTERIA)_YBL092W	YBL092W	"RPL32 - Protein component of the large (60S) ribosomal subunit, has similarity to rat L32 ribosomal protein; overexpression disrupts telomeric silencing"	1	1	0	1	1	0.928571429	1	0.8125
646_OG5_127039_2 - ALL (-BACTERIA)_YBL072C	YBL072C	RPS8A - Protein component of the small (40S) ribosomal subunit; identical to Rps8Bp and has similarity to rat S8 ribosomal protein	1	1	0	1	1	0.928571429	1	1
647_OG5_127039_2 - ALL (-BACTERIA)_YER102W	YER102W	RPS8B - Protein component of the small (40S) ribosomal subunit; identical to Rps8Ap and has similarity to rat S8 ribosomal protein	1	1	0	1	1	0.928571429	1	1
648_OG5_127488_2 - ALL (-BACTERIA)_YPR016C	YPR016C	"TIF6 - Constituent of 66S pre-ribosomal particles, has similarity to human translation initiation factor 6 (eIF6); may be involved in the biogenesis and or stability of 60S ribosomal subunits"	1	1	0	1	1	0.928571429	1	1
649_OG5_126631_2 - ALL (-BACTERIA)_YBR118W	YBR118W	TEF2 - Translational elongation factor EF-1 alpha; also encoded by TEF1; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes; may also have a role in tRNA re-export from the nucleus	1	1	0.055555556	1	0.904761905	1	1	1
650_OG5_126631_2 - ALL (-BACTERIA)_YPR080W	YPR080W	TEF1 - Translational elongation factor EF-1 alpha; also encoded by TEF2; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes; may also have a role in tRNA re-export from the nucleus	1	1	0.055555556	1	0.904761905	1	1	1
651_OG5_126988_2 - ALL (-BACTERIA)_YNL162W	YNL162W	"RPL42A - Protein component of the large (60S) ribosomal subunit, identical to Rpl42Bp and has similarity to rat L44 ribosomal protein"	1	1	0	1	0.952380952	1	0.95	0.9375
652_OG5_126988_2 - ALL (-BACTERIA)_YHR141C	YHR141C	"RPL42B - Protein component of the large (60S) ribosomal subunit, identical to Rpl42Ap and has similarity to rat L44; required for propagation of the killer toxin-encoding M1 double-stranded RNA satellite of the L-A double-stranded RNA virus"	1	1	0	1	0.952380952	1	0.95	0.9375
653_OG5_126896_2 - ALL (-BACTERIA)_YER074W	YER074W	RPS24A - Protein component of the small (40S) ribosomal subunit; identical to Rps24Bp and has similarity to rat S24 ribosomal protein	1	0.9375	0	1	0.952380952	1	1	0.875
654_OG5_126896_2 - ALL (-BACTERIA)_YIL069C	YIL069C	RPS24B - Protein component of the small (40S) ribosomal subunit; identical to Rps24Ap and has similarity to rat S24 ribosomal protein	1	0.9375	0	1	0.952380952	1	1	0.875
655_OG5_127598_2 - ALL (-BACTERIA)_YIL103W	YIL103W	"DPH1 - Protein required, along with Dph2p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph2p and Kti11p"	1	0.9375	0	1	0.952380952	1	1	0.875
656_OG5_126867_2 - ALL (-BACTERIA)_YML024W	YML024W	RPS17A - Ribosomal protein 51 (rp51) of the small (40s) subunit; nearly identical to Rps17Bp and has similarity to rat S17 ribosomal protein	1	0.9375	0	1	1	1	0.95	0.875
657_OG5_126867_2 - ALL (-BACTERIA)_YDR447C	YDR447C	RPS17B - Ribosomal protein 51 (rp51) of the small (40s) subunit; nearly identical to Rps17Ap and has similarity to rat S17 ribosomal protein	1	0.9375	0	1	1	1	0.95	0.875
658_OG5_127237_2 - ALL (-BACTERIA)_YDL185W	YDL185W	"VMA1 - Subunit A of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase; protein precursor undergoes self-catalyzed splicing to yield the extein Tfp1p and the intein Vde (PI-SceI), which is a site-specific endonuclease"	1	1	0.166666667	1	0.952380952	0.928571429	1	0.9375
659_OG5_126957_2 - ALL (-BACTERIA)_YIL133C	YIL133C	"RPL16A - N-terminally acetylated protein component of the large (60S) ribosomal subunit, binds to 5.8 S rRNA; has similarity to Rpl16Bp, E. coli L13 and rat L13a ribosomal proteins; transcriptionally regulated by Rap1p"	1	1	0	1	0.952380952	0.928571429	1	0.9375
660_OG5_126957_2 - ALL (-BACTERIA)_YNL069C	YNL069C	"RPL16B - N-terminally acetylated protein component of the large (60S) ribosomal subunit, binds to 5.8 S rRNA; has similarity to Rpl16Ap, E. coli L13 and rat L13a ribosomal proteins; transcriptionally regulated by Rap1p"	1	1	0	1	0.952380952	0.928571429	1	0.9375
661_OG5_127029_2 - ALL (-BACTERIA)_YPR132W	YPR132W	"RPS23B - Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit, required for translational accuracy; nearly identical to Rps23Ap and similar to E. coli S12 and rat S23 ribosomal proteins; deletion of both RPS23A and RPS23B is lethal"	1	1	0	1	0.952380952	0.928571429	1	1
662_OG5_127029_2 - ALL (-BACTERIA)_YGR118W	YGR118W	"RPS23A - Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit, required for translational accuracy; nearly identical to Rps23Bp and similar to E. coli S12 and rat S23 ribosomal proteins; deletion of both RPS23A and RPS23B is lethal"	1	1	0	1	0.952380952	0.928571429	1	1
663_OG5_127080_2 - ALL (-BACTERIA)_YOL121C	YOL121C	"RPS19A - Protein component of the small (40S) ribosomal subunit, required for assembly and maturation of pre-40 S particles; mutations in human RPS19 are associated with Diamond Blackfan anemia; nearly identical to Rps19Bp"	1	1	0	1	0.952380952	0.928571429	1	0.8125
664_OG5_127080_2 - ALL (-BACTERIA)_YNL302C	YNL302C	"RPS19B - Protein component of the small (40S) ribosomal subunit, required for assembly and maturation of pre-40 S particles; mutations in human RPS19 are associated with Diamond Blackfan anemia; nearly identical to Rps19Ap"	1	1	0	1	0.952380952	0.928571429	1	0.8125
665_OG5_127089_2 - ALL (-BACTERIA)_YDR064W	YDR064W	RPS13 - Protein component of the small (40S) ribosomal subunit; has similarity to E. coli S15 and rat S13 ribosomal proteins	1	1	0	1	0.952380952	0.928571429	1	0.9375
666_OG5_127191_2 - ALL (-BACTERIA)_YDL014W	YDL014W	"NOP1 - Nucleolar protein, component of the small subunit processome complex, which is required for processing of pre-18S rRNA; has similarity to mammalian fibrillarin"	1	1	0	1	0.952380952	0.928571429	1	0.9375
667_OG5_127312_2 - ALL (-BACTERIA)_YAL035W	YAL035W	"FUN12 - GTPase, required for general translation initiation by promoting Met-tRNAiMet binding to ribosomes and ribosomal subunit joining; homolog of bacterial IF2"	1	1	0	1	0.952380952	0.928571429	1	1
668_OG5_127352_2 - ALL (-BACTERIA)_YBR088C	YBR088C	"POL30 - Proliferating cell nuclear antigen (PCNA), functions as the sliding clamp for DNA polymerase delta; may function as a docking site for other proteins required for mitotic and meiotic chromosomal DNA replication and for DNA repair"	1	1	0	1	0.952380952	0.928571429	1	0.9375
669_OG5_127369_2 - ALL (-BACTERIA)_YHR070W	YHR070W	"TRM5 - tRNA(m(1)G37)methyltransferase, methylates a tRNA base adjacent to the anticodon that has a role in prevention of frameshifting; highly conserved across Archaea, Bacteria, and Eukarya"	1	1	0	1	0.952380952	0.928571429	1	0.9375
670_OG5_127433_2 - ALL (-BACTERIA)_YJR007W	YJR007W	"SUI2 - Alpha subunit of the translation initiation factor eIF2, involved in the identification of the start codon; phosphorylation of Ser51 is required for regulation of translation by inhibiting the exchange of GDP for GTP"	1	1	0.055555556	1	1	0.928571429	0.95	0.9375
671_OG5_126986_2 - ALL (-BACTERIA)_YDR025W	YDR025W	RPS11A - Protein component of the small (40S) ribosomal subunit; identical to Rps11Bp and has similarity to E. coli S17 and rat S11 ribosomal proteins	1	1	0	1	1	0.928571429	0.95	0.9375
672_OG5_126986_2 - ALL (-BACTERIA)_YBR048W	YBR048W	RPS11B - Protein component of the small (40S) ribosomal subunit; identical to Rps11Ap and has similarity to E. coli S17 and rat S11 ribosomal proteins	1	1	0	1	1	0.928571429	0.95	0.9375
673_OG5_127100_2 - ALL (-BACTERIA)_YPR103W	YPR103W	"PRE2 - Beta 5 subunit of the 20S proteasome, responsible for the chymotryptic activity of the proteasome"	1	0.9375	0.055555556	1	1	0.928571429	1	1
674_OG5_127154_2 - ALL (-BACTERIA)_YHR020W	YHR020W	"YHR020W - Protein of unknown function that may interact with ribosomes, based on co-purification experiments; has similarity to proline-tRNA ligase; YHR020W is an essential gene"	1	1	0.166666667	1	0.857142857	1	1	1
675_OG5_126983_2 - ALL (-BACTERIA)_YBR189W	YBR189W	RPS9B - Protein component of the small (40S) ribosomal subunit; nearly identical to Rps9Ap and has similarity to E. coli S4 and rat S9 ribosomal proteins	1	1	0	1	1	0.857142857	1	0.9375
676_OG5_126983_2 - ALL (-BACTERIA)_YPL081W	YPL081W	RPS9A - Protein component of the small (40S) ribosomal subunit; nearly identical to Rps9Bp and has similarity to E. coli S4 and rat S9 ribosomal proteins	1	1	0	1	1	0.857142857	1	0.9375
677_OG5_127064_2 - ALL (-BACTERIA)_YJR123W	YJR123W	"RPS5 - Protein component of the small (40S) ribosomal subunit, the least basic of the non-acidic ribosomal proteins; phosphorylated in vivo; essential for viability; has similarity to E. coli S7 and rat S5 ribosomal proteins"	1	1	0	1	1	0.857142857	1	0.9375
678_OG5_127567_2 - ALL (-BACTERIA)_YGR185C	YGR185C	"TYS1 - Cytoplasmic tyrosyl-tRNA synthetase, required for cytoplasmic protein synthesis; interacts with positions 34 and 35 of the tRNATyr anticodon; mutations in human ortholog YARS are associated with Charcot-Marie-Tooth (CMT) neuropathies"	1	1	0	1	0.857142857	1	1	0.9375
679_OG5_127155_2 - ALL (-BACTERIA)_YBL057C	YBL057C	PTH2 - One of two (see also PTH1) mitochondrially-localized peptidyl-tRNA hydrolases; negatively regulates the ubiquitin-proteasome pathway via interactions with ubiquitin-like ubiquitin-associated proteins; dispensable for cell growth	1	1	0	1	0.904761905	1	0.95	1
680_OG5_127443_2 - ALL (-BACTERIA)_YLR172C	YLR172C	"DPH5 - Methyltransferase required for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); not essential for viability; GFP-Dph5p fusion protein localizes to the cytoplasm"	1	0.9375	0	1	0.904761905	1	1	0.9375
681_OG5_127351_2 - ALL (-BACTERIA)_YHR068W	YHR068W	"DYS1 - Deoxyhypusine synthase, catalyzes formation of deoxyhypusine, the first step in hypusine biosynthesis; triggers posttranslational hypusination of translation elongation factor eIF-5A and regulates its intracellular levels; tetrameric"	1	1	0.083333333	1	0.904761905	0.928571429	1	1
682_OG5_127472_2 - ALL (-BACTERIA)_YKL113C	YKL113C	"RAD27 - 5' to 3' exonuclease, 5' flap endonuclease, required for Okazaki fragment processing and maturation as well as for long-patch base-excision repair; member of the S. pombe RAD2/FEN1 family"	1	1	0	1	0.904761905	0.928571429	1	1
683_OG5_127513_2 - ALL (-BACTERIA)_YNL001W	YNL001W	"DOM34 - Protein that, with binding partner Hbs1p, facilitates ribosomal subunit dissociation when translation is stalled; required for RNA cleavage in no-go decay, but reports conflict on endonuclease activity; Pelota ortholog"	1	1	0	1	0.904761905	0.928571429	1	1
684_OG5_127564_2 - ALL (-BACTERIA)_YDL166C	YDL166C	"FAP7 - Essential NTPase required for small ribosome subunit synthesis, mediates processing of the 20S pre-rRNA at site D in the cytoplasm but associates only transiently with 43S preribosomes via Rps14p, may be the endonuclease for site D"	1	1	0	1	0.904761905	0.928571429	1	0.9375
685_OG5_127534_2 - ALL (-BACTERIA)_YJL125C	YJL125C	"GCD14 - Subunit of tRNA (1-methyladenosine) methyltransferase, with Gcd10p, required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression"	1	1	0.111111111	1	0.952380952	0.928571429	0.95	0.8125
686_OG5_127205_2 - ALL (-BACTERIA)_YLR388W	YLR388W	RPS29A - Protein component of the small (40S) ribosomal subunit; nearly identical to Rps29Bp and has similarity to rat S29 and E. coli S14 ribosomal proteins	1	1	0	1	0.952380952	0.928571429	0.95	0.8125
687_OG5_127205_2 - ALL (-BACTERIA)_YDL061C	YDL061C	RPS29B - Protein component of the small (40S) ribosomal subunit; nearly identical to Rps29Ap and has similarity to rat S29 and E. coli S14 ribosomal proteins	1	1	0	1	0.952380952	0.928571429	0.95	0.8125
688_OG5_127328_2 - ALL (-BACTERIA)_YOR289W	YOR289W	YOR289W - Putative protein of unknown function; transcription induced by the unfolded protein response; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus	1	1	0.083333333	0.875	0.952380952	1	1	0.6875
689_OG5_127407_2 - ALL (-BACTERIA)_YPL160W	YPL160W	"CDC60 - Cytosolic leucyl tRNA synthetase, ligates leucine to the appropriate tRNA"	1	0.875	0	1	0.952380952	1	1	0.9375
690_OG5_127464_2 - ALL (-BACTERIA)_YOR145C	YOR145C	"PNO1 - Essential nucleolar protein required for pre-18S rRNA processing, interacts with Dim1p, an 18S rRNA dimethyltransferase, and also with Nob1p, which is involved in proteasome biogenesis; contains a KH domain"	1	0.875	0	1	0.952380952	1	1	1
691_OG5_127349_2 - ALL (-BACTERIA)_YDR120C	YDR120C	"TRM1 - tRNA methyltransferase; two forms of the protein are made by alternative translation starts; localizes to both the nucleus and mitochondrion to produce the modified base N2,N2-dimethylguanosine in tRNAs in both compartments"	1	1	0.027777778	1	0.952380952	0.857142857	1	1
692_OG5_127014_2 - ALL (-BACTERIA)_YLR048W	YLR048W	"RPS0B - Protein component of the small (40S) ribosomal subunit, nearly identical to Rps0Ap; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal"	1	1	0	1	0.952380952	0.857142857	1	0.875
693_OG5_127014_2 - ALL (-BACTERIA)_YGR214W	YGR214W	"RPS0A - Protein component of the small (40S) ribosomal subunit, nearly identical to Rps0Bp; required for maturation of 18S rRNA along with Rps0Bp; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal"	1	1	0	1	0.952380952	0.857142857	1	0.875
694_OG5_127447_2 - ALL (-BACTERIA)_YER025W	YER025W	"GCD11 - Gamma subunit of the translation initiation factor eIF2, involved in the identification of the start codon; binds GTP when forming the ternary complex with GTP and tRNAi-Met"	1	1	0	1	0.857142857	1	0.95	1
695_OG5_127274_2 - ALL (-BACTERIA)_YHL022C	YHL022C	SPO11 - Meiosis-specific protein that initiates meiotic recombination by catalyzing the formation of double-strand breaks in DNA via a transesterification reaction; required for homologous chromosome pairing and synaptonemal complex formation	1	0.9375	0	1	0.857142857	1	1	0.6875
696_OG5_127476_2 - ALL (-BACTERIA)_YOR119C	YOR119C	RIO1 - Essential serine kinase involved in cell cycle progression and processing of the 20S pre-rRNA into mature 18S rRNA	1	1	0.083333333	0.875	0.904761905	1	1	0.9375
697_OG5_127512_2 - ALL (-BACTERIA)_YER007C-A	YER007C-A	TMA20 - Protein of unknown function that associates with ribosomes and has a putative RNA binding domain; interacts with Tma22p; null mutant exhibits translation defects; has homology to human oncogene MCT-1	1	1	0	0.875	0.904761905	1	1	0.9375
698_OG5_127497_2 - ALL (-BACTERIA)_YLR009W	YLR009W	"RLP24 - Essential protein with similarity to Rpl24Ap and Rpl24Bp, associated with pre-60S ribosomal subunits and required for ribosomal large subunit biogenesis"	1	0.9375	0	1	0.904761905	0.928571429	1	0.9375
699_OG5_126808_2 - ALL (-BACTERIA)_YJL194W	YJL194W	"CDC6 - Essential ATP-binding protein required for DNA replication, component of the pre-replicative complex (pre-RC) which requires ORC to associate with chromatin and is in turn required for Mcm2-7p DNA association; homologous to S. pombe Cdc18p"	1	0.8125	0	1	0.952380952	1	1	0.9375
700_OG5_126808_2 - ALL (-BACTERIA)_YML065W	YML065W	"ORC1 - Largest subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; exhibits ATPase activity"	1	0.8125	0	1	0.952380952	1	1	0.9375
701_OG5_127528_2 - ALL (-BACTERIA)_YAL036C	YAL036C	"RBG1 - Member of the DRG family of GTP-binding proteins; associates with translating ribosomes; interacts with Tma46p, Ygr250cp, Gir2p and Yap1p via two-hybrid"	1	0.875	0	1	0.952380952	0.928571429	1	1
702_OG5_127419_2 - ALL (-BACTERIA)_YDR045C	YDR045C	RPC11 - RNA polymerase III subunit C11; mediates pol III RNA cleavage activity and is important for termination of transcription; homologous to TFIIS	1	1	0	1	0.80952381	0.928571429	1	0.9375
703_OG5_127005_2 - ALL (-BACTERIA)_YGL030W	YGL030W	"RPL30 - Protein component of the large (60S) ribosomal subunit, has similarity to rat L30 ribosomal protein; involved in pre-rRNA processing in the nucleolus; autoregulates splicing of its transcript"	1	0.8125	0	1	0.904761905	1	1	1
704_OG5_127008_2 - ALL (-BACTERIA)_YHR021C	YHR021C	RPS27B - Protein component of the small (40S) ribosomal subunit; nearly identical to Rps27Ap and has similarity to rat S27 ribosomal protein	1	1	0	1	0.904761905	0.857142857	0.95	0.875
705_OG5_127008_2 - ALL (-BACTERIA)_YKL156W	YKL156W	RPS27A - Protein component of the small (40S) ribosomal subunit; nearly identical to Rps27Bp and has similarity to rat S27 ribosomal protein	1	1	0	1	0.904761905	0.857142857	0.95	0.875
706_OG5_127046_2 - ALL (-BACTERIA)_YLR264W	YLR264W	RPS28B - Protein component of the small (40S) ribosomal subunit; nearly identical to Rps28Ap and has similarity to rat S28 ribosomal protein	1	1	0	1	0.904761905	0.857142857	0.95	0.875
707_OG5_127046_2 - ALL (-BACTERIA)_YOR167C	YOR167C	RPS28A - Protein component of the small (40S) ribosomal subunit; nearly identical to Rps28Bp and has similarity to rat S28 ribosomal protein	1	1	0	1	0.904761905	0.857142857	0.95	0.875
708_OG5_127345_2 - ALL (-BACTERIA)_YPR187W	YPR187W	"RPO26 - RNA polymerase subunit ABC23, common to RNA polymerases I, II, and III; part of central core; similar to bacterial omega subunit"	1	0.875	0	1	0.952380952	0.928571429	0.95	0.9375
709_OG5_127015_2 - ALL (-BACTERIA)_YOR332W	YOR332W	"VMA4 - Subunit E of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane"	1	0.75	0.111111111	1	0.952380952	1	1	0.8125
710_OG5_126882_2 - ALL (-BACTERIA)_YDR280W	YDR280W	"RRP45 - Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp45p (PM/SCL-75, EXOSC9)"	1	0.75	0	1	0.952380952	1	1	0.9375
711_OG5_127684_2 - ALL (-BACTERIA)_YNL207W	YNL207W	RIO2 - Essential serine kinase involved in the processing of the 20S pre-rRNA into mature 18S rRNA; has similarity to Rio1p	1	0.75	0	1	0.952380952	1	1	0.875
712_OG5_127455_2 - ALL (-BACTERIA)_YBR154C	YBR154C	"RPB5 - RNA polymerase subunit ABC27, common to RNA polymerases I, II, and III; contacts DNA and affects transactivation"	1	0.9375	0	1	0.952380952	0.857142857	0.95	0.9375
713_OG5_126918_2 - ALL (-BACTERIA)_YDR500C	YDR500C	"RPL37B - Protein component of the large (60S) ribosomal subunit, has similarity to Rpl37Ap and to rat L37 ribosomal protein"	1	0.9375	0	1	0.857142857	1	0.9	0.9375
714_OG5_126918_2 - ALL (-BACTERIA)_YLR185W	YLR185W	"RPL37A - Protein component of the large (60S) ribosomal subunit, has similarity to Rpl37Bp and to rat L37 ribosomal protein"	1	0.9375	0	1	0.857142857	1	0.9	0.9375
715_OG5_127536_2 - ALL (-BACTERIA)_YLR143W	YLR143W	YLR143W - Putative protein of unknown function; green fluorescent protein (GFP)-tagged protein localizes to the cytoplasm; YLR143W is not an essential gene	1	0.9375	0.055555556	0.875	0.952380952	0.928571429	1	0.875
716_OG5_126907_2 - ALL (-BACTERIA)_YDL075W	YDL075W	"RPL31A - Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl31Bp and has similarity to rat L31 ribosomal protein; associates with the karyopherin Sxm1p; loss of both Rpl31p and Rpl39p confers lethality"	1	0.8125	0	1	1	0.928571429	0.95	1
717_OG5_126907_2 - ALL (-BACTERIA)_YLR406C	YLR406C	"RPL31B - Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl31Ap and has similarity to rat L31 ribosomal protein; associates with the karyopherin Sxm1p; loss of both Rpl31p and Rpl39p confers lethality"	1	0.8125	0	1	1	0.928571429	0.95	1
718_OG5_127713_2 - ALL (-BACTERIA)_YDR140W	YDR140W	MTQ2 - S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; subunit of complex with Trm112p that methylates translation release factor Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; similar to E.coli PrmC	1	1	0	1	0.80952381	0.928571429	0.95	0.8125
719_OG5_127375_2 - ALL (-BACTERIA)_YDL164C	YDL164C	"CDC9 - DNA ligase found in the nucleus and mitochondria, an essential enzyme that joins Okazaki fragments during DNA replication; also acts in nucleotide excision repair, base excision repair, and recombination"	1	1	0.138888889	1	0.80952381	0.857142857	1	0.9375
720_OG5_127622_2 - ALL (-BACTERIA)_YIL021W	YIL021W	"RPB3 - RNA polymerase II third largest subunit B44, part of central core; similar to prokaryotic alpha subunit"	1	0.75	0	1	0.904761905	1	1	0.9375
721_OG5_127343_2 - ALL (-BACTERIA)_YJR064W	YJR064W	"CCT5 - Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo"	1	0.6875	0.055555556	1	0.952380952	1	1	0.9375
722_OG5_127300_2 - ALL (-BACTERIA)_YPL009C	YPL009C	"TAE2 - Protein of unknown function, involved in protein translation; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm"	1	1	0	1	0.904761905	0.928571429	0.8	0.9375
723_OG5_127149_2 - ALL (-BACTERIA)_YDR091C	YDR091C	RLI1 - Essential iron-sulfur protein required for ribosome biogenesis and translation initiation and termination; facilitates binding of a multifactor complex (MFC) of initiation factors to the small ribosomal subunit; predicted ABC family ATPase	1	1	0.194444444	0.875	0.857142857	1	0.9	0.9375
724_OG5_127322_2 - ALL (-BACTERIA)_YEL026W	YEL026W	"SNU13 - RNA binding protein, part of U3 snoRNP involved in rRNA processing, part of U4/U6-U5 tri-snRNP involved in mRNA splicing, similar to human 15.5K protein"	1	1	0	0.75	0.952380952	0.928571429	1	0.9375
725_OG5_127380_2 - ALL (-BACTERIA)_YNL132W	YNL132W	"KRE33 - Essential protein, required for biogenesis of the small ribosomal subunit; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance"	1	0.625	0.166666667	1	1	1	1	0.9375
726_OG5_127549_2 - ALL (-BACTERIA)_YLR200W	YLR200W	"YKE2 - Subunit of the heterohexameric Gim/prefoldin protein complex involved in the folding of alpha-tubulin, beta-tubulin, and actin"	1	1	0	0.875	0.952380952	0.785714286	1	0.875
727_OG5_127479_2 - ALL (-BACTERIA)_YJR008W	YJR008W	YJR008W - Putative protein of unknown function; expression repressed by inosine and choline in an Opi1p-dependent manner; expression induced by mild heat-stress on a non-fermentable carbon source.	1	0.875	0.138888889	0.875	0.904761905	1	0.95	0.75
728_OG5_126654_2 - ALL (-BACTERIA)_YNL021W	YNL021W	"HDA1 - Putative catalytic subunit of a class II histone deacetylase complex that also contains Hda2p and Hda3p; Hda1p interacts with the Hda2p-Hda3p subcomplex to form an active tetramer; deletion increases histone H2B, H3 and H4 acetylation"	1	0.6875	0.194444444	1	0.904761905	1	1	0.6875
729_OG5_127324_2 - ALL (-BACTERIA)_YPL086C	YPL086C	"ELP3 - Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; exhibits histone acetyltransferase activity that is directed to histones H3 and H4; disruption confers resistance to K. lactis zymotoxin"	1	0.75	0.138888889	1	0.904761905	0.928571429	1	0.9375
730_OG5_127734_2 - ALL (-BACTERIA)_YOR006C	YOR006C	TSR3 - Protein required for correct processing of the 20S pre-rRNA at site D to generate mature 18S rRNA; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus	1	0.75	0	1	0.904761905	0.928571429	1	0.9375
731_OG5_126840_2 - ALL (-BACTERIA)_YGL022W	YGL022W	"STT3 - Subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; forms a subcomplex with Ost3p and Ost4p and is directly involved in catalysis"	1	0.625	0	1	0.952380952	1	1	0.75
732_OG5_127132_2 - ALL (-BACTERIA)_YKL006W	YKL006W	"RPL14A - N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl14Bp and has similarity to rat L14 ribosomal protein; rpl14a csh5 double null mutant exhibits synthetic slow growth"	1	0.6875	0	1	1	0.928571429	0.95	0.875
733_OG5_127132_2 - ALL (-BACTERIA)_YHL001W	YHL001W	"RPL14B - Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl14Ap and has similarity to rat L14 ribosomal protein"	1	0.6875	0	1	1	0.928571429	0.95	0.875
734_OG5_127456_2 - ALL (-BACTERIA)_YDL007W	YDL007W	RPT2 - One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for normal peptide hydrolysis by the core 20S particle	1	0.5625	0.027777778	1	1	1	1	0.9375
735_OG5_127022_2 - ALL (-BACTERIA)_YDR418W	YDR418W	"RPL12B - Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl12Ap; rpl12a rpl12b double mutant exhibits slow growth and slow translation; has similarity to E. coli L11 and rat L12 ribosomal proteins"	1	0.5625	0	1	1	1	1	0.9375
736_OG5_127022_2 - ALL (-BACTERIA)_YEL054C	YEL054C	"RPL12A - Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl12Bp; rpl12a rpl12b double mutant exhibits slow growth and slow translation; has similarity to E. coli L11 and rat L12 ribosomal proteins"	1	0.5625	0	1	1	1	1	0.9375
737_OG5_127208_2 - ALL (-BACTERIA)_YIL143C	YIL143C	"SSL2 - Component of the holoenzyme form of RNA polymerase transcription factor TFIIH, has DNA-dependent ATPase/helicase activity and is required, with Rad3p, for unwinding promoter DNA; involved in DNA repair; homolog of human ERCC3"	1	0.625	0.111111111	1	1	0.928571429	1	0.9375
738_OG5_127025_2 - ALL (-BACTERIA)_YIL052C	YIL052C	"RPL34B - Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl34Ap and has similarity to rat L34 ribosomal protein"	1	0.625	0	1	1	0.928571429	1	0.8125
739_OG5_127025_2 - ALL (-BACTERIA)_YER056C-A	YER056C-A	"RPL34A - Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl34Bp and has similarity to rat L34 ribosomal protein"	1	0.625	0	1	1	0.928571429	1	0.8125
740_OG5_127483_2 - ALL (-BACTERIA)_YJL014W	YJL014W	"CCT3 - Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo"	1	0.625	0	1	1	0.928571429	1	0.9375
741_OG5_127356_2 - ALL (-BACTERIA)_YIR022W	YIR022W	"SEC11 - 18kDa catalytic subunit of the Signal Peptidase Complex (SPC; Spc1p, Spc2p, Spc3p, and Sec11p) which cleaves the signal sequence of proteins targeted to the endoplasmic reticulum"	1	0.6875	0.055555556	1	0.857142857	1	1	0.9375
742_OG5_127176_2 - ALL (-BACTERIA)_YDL191W	YDL191W	"RPL35A - Protein component of the large (60S) ribosomal subunit, identical to Rpl35Bp and has similarity to rat L35 ribosomal protein"	1	0.625	0	1	0.952380952	1	0.95	0.9375
743_OG5_127176_2 - ALL (-BACTERIA)_YDL136W	YDL136W	"RPL35B - Protein component of the large (60S) ribosomal subunit, identical to Rpl35Ap and has similarity to rat L35 ribosomal protein"	1	0.625	0	1	0.952380952	1	0.95	0.9375
744_OG5_126803_2 - ALL (-BACTERIA)_YPL234C	YPL234C	"VMA11 - Vacuolar ATPase V0 domain subunit c', involved in proton transport activity; hydrophobic integral membrane protein (proteolipid) containing four transmembrane segments; N and C termini are in the vacuolar lumen"	1	0.6875	0.138888889	1	0.904761905	0.928571429	1	0.875
745_OG5_126803_2 - ALL (-BACTERIA)_YEL027W	YEL027W	VMA3 - Proteolipid subunit of the vacuolar H(+)-ATPase V0 sector (subunit c; dicyclohexylcarbodiimide binding subunit); required for vacuolar acidification and important for copper and iron metal ion homeostasis	1	0.6875	0.138888889	1	0.904761905	0.928571429	1	0.875
746_OG5_127672_2 - ALL (-BACTERIA)_YBR243C	YBR243C	"ALG7 - UDP-N-acetyl-glucosamine-1-P transferase, transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first step of the dolichol pathway of protein asparagine-linked glycosylation; inhibited by tunicamycin"	1	0.6875	0	1	0.904761905	0.928571429	1	0.875
747_OG5_128555_2 - ALL (-BACTERIA)_YNL232W	YNL232W	CSL4 - Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain an S1 RNA binding domain; has similarity to human hCsl4p (EXOSC1)	1	0.6875	0	1	0.904761905	0.928571429	1	0.5
748_OG5_127589_2 - ALL (-BACTERIA)_YKL144C	YKL144C	"RPC25 - RNA polymerase III subunit C25, required for transcription initiation; forms a heterodimer with Rpc17p; paralog of Rpb7p"	1	0.5625	0	1	0.952380952	1	1	0.9375
749_OG5_127653_2 - ALL (-BACTERIA)_YHR069C	YHR069C	RRP4 - Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain RNA binding domains; has similarity to human hRrp4p (EXOSC2)	1	0.75	0	1	0.952380952	0.857142857	0.95	1
750_OG5_127181_2 - ALL (-BACTERIA)_YDL100C	YDL100C	"GET3 - Guanine nucleotide exchange factor for Gpa1p; amplifies G protein signaling; subunit of the GET complex, which is involved in Golgi to ER trafficking and insertion of proteins into the ER membrane; has low-level ATPase activity"	1	0.625	0.194444444	1	0.952380952	0.928571429	1	0.75
751_OG5_127563_2 - ALL (-BACTERIA)_YJR072C	YJR072C	"NPA3 - Essential, conserved, cytoplasmic ATPase; phosphorylated by the Pcl1p-Pho85p kinase complex"	1	0.625	0	1	0.952380952	0.928571429	1	1
752_OG5_127592_2 - ALL (-BACTERIA)_YOR310C	YOR310C	"NOP58 - Protein involved in pre-rRNA processing, 18S rRNA synthesis, and snoRNA synthesis; component of the small subunit processome complex, which is required for processing of pre-18S rRNA"	1	0.625	0	1	0.952380952	0.928571429	1	1
753_OG5_127600_2 - ALL (-BACTERIA)_YOL094C	YOL094C	"RFC4 - Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon"	1	0.5	0.027777778	1	1	1	1	0.9375
754_OG5_127711_2 - ALL (-BACTERIA)_YMR074C	YMR074C	"YMR074C - Protein with homology to human PDCD5, which is involved in programmed cell death; N-terminal region forms a conserved triple-helix bundle structure; overexpression promotes H2O2-induced apoptosis; YMR074C is not an essential gene"	1	1	0	0.75	0.904761905	0.928571429	0.9	0.6875
755_OG5_128121_2 - ALL (-BACTERIA)_YML105C	YML105C	"SEC65 - Subunit of the signal recognition particle (SRP), involved in protein targeting to the ER; interacts with Srp54p; homolog of mammalian SRP19"	1	0.75	0	1	0.904761905	0.857142857	0.95	0.6875
756_OG5_127691_2 - ALL (-BACTERIA)_YOR210W	YOR210W	"RPB10 - RNA polymerase subunit ABC10-beta, common to RNA polymerases I, II, and III"	1	1	0	1	0.904761905	0.642857143	0.9	0.9375
757_OG5_127688_2 - ALL (-BACTERIA)_YOL005C	YOL005C	RPB11 - RNA polymerase II subunit B12.5; part of central core; similar to Rpc19p and bacterial alpha subunit	1	0.5625	0	1	0.952380952	0.928571429	1	0.875
758_OG5_126834_2 - ALL (-BACTERIA)_YER095W	YER095W	"RAD51 - Strand exchange protein, forms a helical filament with DNA that searches for homology; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; homolog of Dmc1p and bacterial RecA protein"	1	1	0	0.75	0.857142857	0.928571429	0.9	0.9375
759_OG5_126834_2 - ALL (-BACTERIA)_YER179W	YER179W	DMC1 - Meiosis-specific protein required for repair of double-strand breaks and pairing between homologous chromosomes; homolog of Rad51p and the bacterial RecA protein	1	1	0	0.75	0.857142857	0.928571429	0.9	0.9375
760_OG5_128649_2 - ALL (-BACTERIA)_YIR002C	YIR002C	"MPH1 - Member of the DEAH family of helicases, functions in an error-free DNA damage bypass pathway that involves homologous recombination, binds to flap DNA and stimulates activity of Rad27p and Dna2p; mutations confer a mutator phenotype"	1	0.625	0	1	0.857142857	1	0.95	0.1875
761_OG5_127807_2 - ALL (-BACTERIA)_YBR242W	YBR242W	YBR242W - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR242W is not an essential gene	1	0.5625	0.166666667	1	0.857142857	1	1	0.5625
762_OG5_127807_2 - ALL (-BACTERIA)_YGL101W	YGL101W	YGL101W - Putative protein of unknown function; non-essential gene with similarity to YBR242W; interacts with the DNA helicase Hpr5p	1	0.5625	0.166666667	1	0.857142857	1	1	0.5625
763_OG5_126998_2 - ALL (-BACTERIA)_YGR027C	YGR027C	RPS25A - Protein component of the small (40S) ribosomal subunit; nearly identical to Rps25Bp and has similarity to rat S25 ribosomal protein	1	0.5	0	1	0.952380952	1	0.95	0.9375
764_OG5_126998_2 - ALL (-BACTERIA)_YLR333C	YLR333C	RPS25B - Protein component of the small (40S) ribosomal subunit; nearly identical to Rps25Ap and has similarity to rat S25 ribosomal protein	1	0.5	0	1	0.952380952	1	0.95	0.9375
765_OG5_127602_2 - ALL (-BACTERIA)_YOR250C	YOR250C	"CLP1 - Subunit of cleavage factor I (CFI), involved in both the endonucleolyitc cleavage and polyadenylation steps of mRNA 3'-end maturation"	1	0.5625	0	1	0.904761905	0.928571429	1	0.9375
766_OG5_127424_2 - ALL (-BACTERIA)_YOL038W	YOL038W	PRE6 - Alpha 4 subunit of the 20S proteasome; may replace alpha 3 subunit (Pre9p) under stress conditions to create a more active proteasomal isoform; GFP-fusion protein relocates from cytosol to the mitochondrial surface upon oxidative stress	1	0.4375	0	1	0.952380952	1	1	0.8125
767_OG5_127631_2 - ALL (-BACTERIA)_YPR019W	YPR019W	MCM4 - Essential helicase component of heterohexameric MCM2-7 complexes which bind pre-replication complexes on DNA and melt DNA prior to replication; forms an Mcm4p-6p-7p subcomplex; shows nuclear accumulation in G1; homolog of S. pombe Cdc21p	1	0.5625	0	0.875	0.952380952	1	1	0.9375
768_OG5_127764_2 - ALL (-BACTERIA)_YBL023C	YBL023C	MCM2 - Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex	1	0.4375	0	1	0.952380952	1	1	1
769_OG5_127977_2 - ALL (-BACTERIA)_YPL022W	YPL022W	"RAD1 - Single-stranded DNA endonuclease (with Rad10p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human XPF protein"	1	0.4375	0	1	0.952380952	1	1	0.625
770_OG5_127748_2 - ALL (-BACTERIA)_YLR186W	YLR186W	EMG1 - Member of the alpha/beta knot fold methyltransferase superfamily; required for maturation of 18S rRNA and for 40S ribosome production; interacts with RNA and with S-adenosylmethionine; associates with spindle/microtubules; forms homodimers	1	0.625	0	1	0.904761905	0.857142857	1	0.9375
771_OG5_127573_2 - ALL (-BACTERIA)_YNR053C	YNR053C	NOG2 - Putative GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation	1	0.4375	0	1	0.904761905	1	1	1
772_OG5_127415_2 - ALL (-BACTERIA)_YGL211W	YGL211W	"NCS6 - Protein required for thiolation of the uridine at the wobble position of Gln, Lys, and Glu tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae"	1	0.9375	0.166666667	0.75	0.857142857	0.785714286	1	0.875
773_OG5_127553_2 - ALL (-BACTERIA)_YHR012W	YHR012W	VPS29 - Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval	1	0.5	0.055555556	0.875	0.952380952	1	1	0.75
774_OG5_127128_2 - ALL (-BACTERIA)_YMR142C	YMR142C	"RPL13B - Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl13Ap; not essential for viability; has similarity to rat L13 ribosomal protein"	1	0.375	0	1	0.952380952	1	1	0.9375
775_OG5_127128_2 - ALL (-BACTERIA)_YDL082W	YDL082W	"RPL13A - Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl13Bp; not essential for viability; has similarity to rat L13 ribosomal protein"	1	0.375	0	1	0.952380952	1	1	0.9375
776_OG5_127593_2 - ALL (-BACTERIA)_YGR253C	YGR253C	PUP2 - Alpha 5 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit zeta	1	0.375	0	1	0.952380952	1	1	1
777_OG5_127376_2 - ALL (-BACTERIA)_YJL189W	YJL189W	"RPL39 - Protein component of the large (60S) ribosomal subunit, has similarity to rat L39 ribosomal protein; required for ribosome biogenesis; loss of both Rpl31p and Rpl39p confers lethality; also exhibits genetic interactions with SIS1 and PAB1"	1	0.875	0	1	0.80952381	0.785714286	0.85	0.75
778_OG5_127673_2 - ALL (-BACTERIA)_YGR262C	YGR262C	"BUD32 - Protein kinase, component of the EKC/KEOPS complex with Kae1p, Cgi121p, Pcc1p, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription"	1	0.625	0.027777778	1	0.904761905	0.785714286	1	1
779_OG5_126872_2 - ALL (-BACTERIA)_YDL081C	YDL081C	"RPP1A - Ribosomal stalk protein P1 alpha, involved in the interaction between translational elongation factors and the ribosome; accumulation of P1 in the cytoplasm is regulated by phosphorylation and interaction with the P2 stalk component"	1	0.5	0	1	0.952380952	0.857142857	1	0.8125
780_OG5_126872_2 - ALL (-BACTERIA)_YDL130W	YDL130W	"RPP1B - Ribosomal protein P1 beta, component of the ribosomal stalk, which is involved in interaction of translational elongation factors with ribosome; accumulation is regulated by phosphorylation and interaction with the P2 stalk component"	1	0.5	0	1	0.952380952	0.857142857	1	0.8125
781_OG5_128736_2 - ALL (-BACTERIA)_YLR105C	YLR105C	"SEN2 - Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen2p contains the active site for tRNA 5' splice site cleavage and has similarity to Sen34p and to Archaeal tRNA splicing endonuclease"	1	0.75	0	0.875	0.666666667	1	1	0.25
782_OG5_128248_2 - ALL (-BACTERIA)_YDR294C	YDR294C	"DPL1 - Dihydrosphingosine phosphate lyase, regulates intracellular levels of sphingolipid long-chain base phosphates (LCBPs), degrades phosphorylated long chain bases, prefers C16 dihydrosphingosine-l-phosphate as a substrate"	1	0.4375	0.027777778	1	0.952380952	1	0.9	0.3125
783_OG5_127269_2 - ALL (-BACTERIA)_YLR287C-A	YLR287C-A	RPS30A - Protein component of the small (40S) ribosomal subunit; nearly identical to Rps30Bp and has similarity to rat S30 ribosomal protein	1	0.5	0	1	0.952380952	0.928571429	0.9	0.6875
784_OG5_127269_2 - ALL (-BACTERIA)_YOR182C	YOR182C	RPS30B - Protein component of the small (40S) ribosomal subunit; nearly identical to Rps30Ap and has similarity to rat S30 ribosomal protein	1	0.5	0	1	0.952380952	0.928571429	0.9	0.6875
785_OG5_127981_2 - ALL (-BACTERIA)_YDR404C	YDR404C	RPB7 - RNA polymerase II subunit B16; forms two subunit dissociable complex with Rpb4p; involved in recruitment of 3'-end processing factors to transcribing RNA polymerase II complex and in export of mRNA to cytoplasm under stress conditions	1	0.4375	0	1	0.904761905	0.928571429	1	0.8125
786_OG5_126742_2 - ALL (-BACTERIA)_YNL330C	YNL330C	"RPD3 - Histone deacetylase; regulates transcription, silencing, and other processes by influencing chromatin remodeling; forms at least two different complexes which have distinct functions and members"	1	0.25	0.166666667	1	1	1	1	1
787_OG5_126701_2 - ALL (-BACTERIA)_YGR271W	YGR271W	"SLH1 - Putative RNA helicase related to Ski2p, involved in translation inhibition of non-poly(A) mRNAs; required for repressing propagation of dsRNA viruses"	1	0.25	0.027777778	1	1	1	1	1
788_OG5_126701_2 - ALL (-BACTERIA)_YER172C	YER172C	BRR2 - RNA-dependent ATPase RNA helicase (DEIH box); required for disruption of U4/U6 base-pairing in native snRNPs to activate the spliceosome for catalysis; homologous to human U5-200kD	1	0.25	0.027777778	1	1	1	1	1
789_OG5_128507_2 - ALL (-BACTERIA)_YNL048W	YNL048W	"ALG11 - Alpha-1,2-mannosyltransferase, catalyzes sequential addition of the two terminal alpha 1,2-mannose residues to the Man5GlcNAc2-PP-dolichol intermediate during asparagine-linked glycosylation in the ER"	1	0.4375	0	1	0.952380952	0.857142857	1	0.4375
790_OG5_127138_2 - ALL (-BACTERIA)_YER131W	YER131W	RPS26B - Protein component of the small (40S) ribosomal subunit; nearly identical to Rps26Ap and has similarity to rat S26 ribosomal protein	1	0.5	0	1	1	0.785714286	0.95	0.9375
791_OG5_127138_2 - ALL (-BACTERIA)_YGL189C	YGL189C	RPS26A - Protein component of the small (40S) ribosomal subunit; nearly identical to Rps26Bp and has similarity to rat S26 ribosomal protein	1	0.5	0	1	1	0.785714286	0.95	0.9375
792_OG5_128346_2 - ALL (-BACTERIA)_YLR438C-A	YLR438C-A	"LSM3 - Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA"	1	0.5625	0	1	0.904761905	0.857142857	0.9	0.6875
793_OG5_127630_2 - ALL (-BACTERIA)_YML014W	YML014W	"TRM9 - tRNA methyltransferase, catalyzes esterification of modified uridine nucleotides in tRNA(Arg3) and tRNA(Glu), likely as part of a complex with Trm112p; deletion confers resistance to zymocin"	1	0.4375	0.055555556	0.875	0.904761905	1	1	0.9375
794_OG5_127221_2 - ALL (-BACTERIA)_YLR167W	YLR167W	RPS31 - Fusion protein that is cleaved to yield a ribosomal protein of the small (40S) subunit and ubiquitin; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; interacts genetically with translation factor eIF2B	1	0.4375	0	0.875	0.904761905	1	1	0.9375
795_OG5_127125_2 - ALL (-BACTERIA)_YGL105W	YGL105W	"ARC1 - Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases (Mes1p and Gus1p), delivering tRNA to them, stimulating catalysis, and ensuring their localization to the cytoplasm; also binds quadruplex nucleic acids"	1	0.5625	0.055555556	1	0.714285714	0.928571429	1	0.875
796_OG5_126845_2 - ALL (-BACTERIA)_YOL039W	YOL039W	"RPP2A - Ribosomal protein P2 alpha, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm"	1	0.4375	0	0.875	0.952380952	0.928571429	1	1
797_OG5_126845_2 - ALL (-BACTERIA)_YDR382W	YDR382W	"RPP2B - Ribosomal protein P2 beta, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm"	1	0.4375	0	0.875	0.952380952	0.928571429	1	1
798_OG5_127820_2 - ALL (-BACTERIA)_YML094W	YML094W	GIM5 - Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it	1	0.5	0	0.875	0.952380952	0.857142857	1	0.875
799_OG5_127679_2 - ALL (-BACTERIA)_YDR339C	YDR339C	FCF1 - Putative PINc domain nuclease required for early cleavages of 35S pre-rRNA and maturation of 18S rRNA; component of the SSU (small subunit) processome involved in 40S ribosomal subunit biogenesis; copurifies with Faf1p	1	0.25	0	1	1	0.928571429	1	1
800_OG5_128320_2 - ALL (-BACTERIA)_YGR277C	YGR277C	"CAB4 - Probable pantetheine-phosphate adenylyltransferase (PPAT), which catalyzes the fourth step in the biosynthesis of coenzyme A from pantothenate; null mutant lethality is complemented by E. coli coaD (encoding PPAT); widely conserved"	1	0.625	0	0.875	0.857142857	0.857142857	0.95	0.375
801_OG5_128591_2 - ALL (-BACTERIA)_YPL227C	YPL227C	"ALG5 - UDP-glucose:dolichyl-phosphate glucosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum"	1	0.625	0.138888889	0.875	0.761904762	1	0.9	0.375
802_OG5_127848_2 - ALL (-BACTERIA)_YLR197W	YLR197W	NOP56 - Essential evolutionarily-conserved nucleolar protein component of the box C/D snoRNP complexes that direct 2'-O-methylation of pre-rRNA during its maturation; overexpression causes spindle orientation defects	1	0.375	0	1	0.857142857	0.928571429	1	1
803_OG5_127805_2 - ALL (-BACTERIA)_YKR026C	YKR026C	"GCN3 - Alpha subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a positive regulator of GCN4 expression"	1	0.4375	0.027777778	0.75	0.952380952	1	1	0.6875
804_OG5_127585_2 - ALL (-BACTERIA)_YER171W	YER171W	"RAD3 - 5' to 3' DNA helicase, involved in nucleotide excision repair and transcription; subunit of RNA polII initiation factor TFIIH and of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPD protein; mutant has aneuploidy tolerance"	1	0.25	0.083333333	1	0.952380952	0.928571429	1	1
805_OG5_127819_2 - ALL (-BACTERIA)_YPR110C	YPR110C	"RPC40 - RNA polymerase subunit AC40, common to RNA polymerase I and III"	1	0.25	0	0.875	1	1	1	1
806_OG5_128342_2 - ALL (-BACTERIA)_YGL115W	YGL115W	"SNF4 - Activating gamma subunit of the AMP-activated Snf1p kinase complex (contains Snf1p and a Sip1p/Sip2p/Gal83p family member); activates glucose-repressed genes, represses glucose-induced genes; role in sporulation, and peroxisome biogenesis"	1	0.3125	0	1	0.857142857	1	0.95	0.1875
807_OG5_127952_2 - ALL (-BACTERIA)_YHR072W-A	YHR072W-A	"NOP10 - Constituent of small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs, which are required for pseudouridylation and processing of pre-18S rRNA"	1	0.6875	0	0.875	0.857142857	0.785714286	0.9	0.875
808_OG5_127703_2 - ALL (-BACTERIA)_YGR211W	YGR211W	"ZPR1 - Essential protein with two zinc fingers, present in the nucleus of growing cells but relocates to the cytoplasm in starved cells via a process mediated by Cpr1p; binds to translation elongation factor eEF-1 (Tef1p)"	1	0.75	0	0.5	0.904761905	0.928571429	1	0.875
809_OG5_127526_2 - ALL (-BACTERIA)_YML126C	YML126C	"ERG13 - 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase, catalyzes the formation of HMG-CoA from acetyl-CoA and acetoacetyl-CoA; involved in the second step in mevalonate biosynthesis"	1	0.4375	0.166666667	0.75	0.857142857	1	1	0.5
810_OG5_128108_2 - ALL (-BACTERIA)_YKL215C	YKL215C	OXP1 - 5-oxoprolinase; enzyme is ATP-dependent and functions as a dimer; similar to mouse Oplah gene; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	1	0.5	0.138888889	0.875	0.80952381	0.857142857	1	0.1875
811_OG5_128065_2 - ALL (-BACTERIA)_YPL207W	YPL207W	"TYW1 - Protein required for the synthesis of wybutosine, a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions"	1	0.9375	0	1	0.285714286	1	0.8	0.625
812_OG5_127072_2 - ALL (-BACTERIA)_YOR234C	YOR234C	"RPL33B - Ribosomal protein L37 of the large (60S) ribosomal subunit, nearly identical to Rpl33Ap and has similarity to rat L35a; rpl33b null mutant exhibits normal growth while rpl33a rpl33b double null mutant is inviable"	1	0.25	0	1	0.952380952	0.857142857	0.95	0.875
813_OG5_127072_2 - ALL (-BACTERIA)_YPL143W	YPL143W	"RPL33A - N-terminally acetylated ribosomal protein L37 of the large (60S) ribosomal subunit, nearly identical to Rpl33Bp and has similarity to rat L35a; rpl33a null mutant exhibits slow growth while rpl33a rpl33b double null mutant is inviable"	1	0.25	0	1	0.952380952	0.857142857	0.95	0.875
814_OG5_128701_2 - ALL (-BACTERIA)_YMR310C	YMR310C	YMR310C - Putative protein of unknown function; predicted to be involved in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR310C is not an essential gene	1	0.6875	0	0.75	0.857142857	1	0.7	0.5
815_OG5_128701_2 - ALL (-BACTERIA)_YGR283C	YGR283C	"YGR283C - Protein of unknown function; may interact with ribosomes, based on co-purification experiments; predicted to be involved in ribosome biogenesis; null mutant is resistant to fluconazole; GFP-fusion protein localizes to the nucleolus"	1	0.6875	0	0.75	0.857142857	1	0.7	0.5
816_OG5_128002_2 - ALL (-BACTERIA)_YPL235W	YPL235W	RVB2 - Essential protein involved in transcription regulation; component of chromatin remodeling complexes; required for assembly and function of the INO80 complex; also referred to as reptin; member of the RUVB-like protein family	1	0.3125	0.027777778	1	0.857142857	0.857142857	0.95	0.9375
817_OG5_128559_2 - ALL (-BACTERIA)_YMR130W	YMR130W	YMR130W - Putative protein of unknown function; YMR130W is not an essential gene	1	0.375	0.083333333	1	0.714285714	0.928571429	0.95	0.0625
818_OG5_127955_2 - ALL (-BACTERIA)_YLR450W	YLR450W	"HMG2 - One of two isozymes of HMG-CoA reductase that convert HMG-CoA to mevalonate, a rate-limiting step in sterol biosynthesis; overproduction induces assembly of peripheral ER membrane arrays and short nuclear-associated membrane stacks"	1	0.6875	0.055555556	0.5	0.80952381	0.928571429	1	0.3125
819_OG5_127955_2 - ALL (-BACTERIA)_YML075C	YML075C	"HMG1 - One of two isozymes of HMG-CoA reductase that catalyzes the conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; localizes to the nuclear envelope; overproduction induces the formation of karmellae"	1	0.6875	0.055555556	0.5	0.80952381	0.928571429	1	0.3125
820_OG5_128262_2 - ALL (-BACTERIA)_YDR378C	YDR378C	"LSM6 - Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA"	1	0.5	0	1	0.714285714	0.857142857	0.85	0.6875
821_OG5_128331_2 - ALL (-BACTERIA)_YMR208W	YMR208W	"ERG12 - Mevalonate kinase, acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate"	1	0.875	0.111111111	0.5	0.80952381	0.857142857	0.8	0.5
822_OG5_128468_2 - ALL (-BACTERIA)_YKL017C	YKL017C	HCS1 - Hexameric DNA polymerase alpha-associated DNA helicase A involved in lagging strand DNA synthesis; contains single-stranded DNA stimulated ATPase and dATPase activities; replication protein A stimulates helicase and ATPase activities	1	0.3125	0.111111111	1	0.428571429	1	1	0.375
823_OG5_127994_2 - ALL (-BACTERIA)_YML060W	YML060W	"OGG1 - Mitochondrial glycosylase/lyase that specifically excises 7,8-dihydro-8-oxoguanine residues located opposite cytosine or thymine residues in DNA, repairs oxidative damage to mitochondrial DNA, contributes to UVA resistance"	1	0.25	0.083333333	0.75	0.761904762	1	0.95	0.875
824_OG5_127645_2 - ALL (-BACTERIA)_YOL102C	YOL102C	"TPT1 - tRNA 2'-phosphotransferase, catalyzes the final step in yeast tRNA splicing: the transfer of the 2'-PO(4) from the splice junction to NAD(+) to form ADP-ribose 1''-2''cyclic phosphate and nicotinamide"	1	0.3125	0.166666667	0.75	0.714285714	0.928571429	1	0.5
825_OG5_128252_2 - ALL (-BACTERIA)_YNR043W	YNR043W	"MVD1 - Mevalonate pyrophosphate decarboxylase, essential enzyme involved in the biosynthesis of isoprenoids and sterols, including ergosterol; acts as a homodimer"	1	0.3125	0.111111111	0.5	0.857142857	1	1	0.5
826_OG5_129257_2 - ALL (-BACTERIA)_YNR050C	YNR050C	"LYS9 - Saccharopine dehydrogenase (NADP+, L-glutamate-forming); catalyzes the formation of saccharopine from alpha-aminoadipate 6-semialdehyde, the seventh step in lysine biosynthesis pathway; exhibits genetic and physical interactions with TRM112"	1	0.25	0.111111111	0.5	0.80952381	1	1	0.0625
827_OG5_129346_2 - ALL (-BACTERIA)_YML005W	YML005W	TRM12 - S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; required for wybutosine formation in phenylalanine-accepting tRNA	1	0.375	0	0.75	0.428571429	0.928571429	0.75	0.4375
828_OG5_129765_2 - ALL (-BACTERIA)_YGL050W	YGL050W	"TYW3 - tRNA methyltransferase required for synthesis of wybutosine, a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions"	1	0.6875	0	0.25	0.285714286	0.928571429	0.75	0.3125
829_OG5_130172_2 - ALL (-BACTERIA)_YGL156W	YGL156W	"AMS1 - Vacuolar alpha mannosidase, involved in free oligosaccharide (fOS) degradation; delivered to the vacuole in a novel pathway separate from the secretory pathway"	1	0.25	0.138888889	0.375	0.238095238	0.928571429	0.95	0.0625
830_OG5_127532_3 - ALL (-ANIMALS)_YHR106W	YHR106W	"TRR2 - Mitochondrial thioredoxin reductase involved in protection against oxidative stress, required with Glr1p to maintain the redox state of Trx3p; contains active-site motif (CAVC) present in prokaryotic orthologs; binds NADPH and FAD"	1	1	1	1	0.285714286	0	1	0.25
831_OG5_127532_3 - ALL (-ANIMALS)_YDR353W	YDR353W	"TRR1 - Cytoplasmic thioredoxin reductase, key regulatory enzyme that determines the redox state of the thioredoxin system, which acts as a disulfide reductase system and protects cells against both oxidative and reductive stress"	1	1	1	1	0.285714286	0	1	0.25
832_OG5_128018_3 - ALL (-ANIMALS)_YER052C	YER052C	HOM3 - Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis	1	0.8125	0.944444444	1	0.238095238	0	1	0.1875
833_OG5_127122_3 - ALL (-ANIMALS)_YBR153W	YBR153W	RIB7 - Diaminohydroxyphoshoribosylaminopyrimidine deaminase; catalyzes the second step of the riboflavin biosynthesis pathway	1	0.8125	0.888888889	1	0.476190476	0	1	0.3125
834_OG5_127183_3 - ALL (-ANIMALS)_YDR127W	YDR127W	"ARO1 - Pentafunctional arom protein, catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids"	1	0.8125	0.888888889	1	0.285714286	0	1	0.25
835_OG5_128304_3 - ALL (-ANIMALS)_YGL148W	YGL148W	"ARO2 - Bifunctional chorismate synthase and flavin reductase, catalyzes the conversion of 5-enolpyruvylshikimate 3-phosphate (EPSP) to form chorismate, which is a precursor to aromatic amino acids"	1	0.8125	0.888888889	1	0.285714286	0	1	0.25
836_OG5_127275_3 - ALL (-ANIMALS)_YBL033C	YBL033C	RIB1 - GTP cyclohydrolase II; catalyzes the first step of the riboflavin biosynthesis pathway	1	0.8125	0.888888889	1	0.142857143	0	1	0.0625
837_OG5_127275_3 - ALL (-ANIMALS)_YDR487C	YDR487C	"RIB3 - 3,4-dihydroxy-2-butanone-4-phosphate synthase (DHBP synthase), required for riboflavin biosynthesis from ribulose-5-phosphate, also has an unrelated function in mitochondrial respiration"	1	0.8125	0.888888889	1	0.142857143	0	1	0.0625
838_OG5_128902_3 - ALL (-ANIMALS)_YOL143C	YOL143C	"RIB4 - Lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, also known as DMRL synthase); catalyzes synthesis of immediate precursor to riboflavin"	1	0.8125	0.888888889	1	0.142857143	0	1	0.0625
839_OG5_128016_3 - ALL (-ANIMALS)_YGL026C	YGL026C	"TRP5 - Tryptophan synthase, catalyzes the last step of tryptophan biosynthesis; regulated by the general control system of amino acid biosynthesis"	1	0.875	0.805555556	1	0.19047619	0	1	0.125
840_OG5_127668_3 - ALL (-ANIMALS)_YOR128C	YOR128C	"ADE2 - Phosphoribosylaminoimidazole carboxylase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway; red pigment accumulates in mutant cells deprived of adenine"	1	0.75	0.888888889	1	0.142857143	0	1	0.0625
841_OG5_128434_3 - ALL (-ANIMALS)_YNL316C	YNL316C	"PHA2 - Prephenate dehydratase, catalyzes the conversion of prephanate to phenylpyruvate, which is a step in the phenylalanine biosynthesis pathway"	1	0.875	0.75	1	0.142857143	0	1	0
842_OG5_127656_3 - ALL (-ANIMALS)_YIL116W	YIL116W	"HIS5 - Histidinol-phosphate aminotransferase, catalyzes the seventh step in histidine biosynthesis; responsive to general control of amino acid biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts"	1	0.8125	0.777777778	1	0.142857143	0	1	0.25
843_OG5_128664_3 - ALL (-ANIMALS)_YDR158W	YDR158W	"HOM2 - Aspartic beta semi-aldehyde dehydrogenase, catalyzes the second step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis"	1	0.75	0.833333333	1	0.238095238	0	1	0.1875
844_OG5_128544_3 - ALL (-ANIMALS)_YER090W	YER090W	"TRP2 - Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p"	1	0.75	0.833333333	1	0.142857143	0	1	0.0625
845_OG5_128100_3 - ALL (-ANIMALS)_YKR069W	YKR069W	"MET1 - S-adenosyl-L-methionine uroporphyrinogen III transmethylase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis"	1	0.8125	0.694444444	1	0.333333333	0	1	0.0625
846_OG5_128063_3 - ALL (-ANIMALS)_YJR139C	YJR139C	"HOM6 - Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase), dimeric enzyme that catalyzes the third step in the common pathway for methionine and threonine biosynthesis; enzyme has nucleotide-binding, dimerization and catalytic regions"	1	0.75	0.75	1	0.19047619	0	1	0.125
847_OG5_129303_3 - ALL (-ANIMALS)_YDR354W	YDR354W	"TRP4 - Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis"	1	0.75	0.75	1	0.047619048	0	1	0.0625
848_OG5_128618_3 - ALL (-ANIMALS)_YJR016C	YJR016C	"ILV3 - Dihydroxyacid dehydratase, catalyzes third step in the common pathway leading to biosynthesis of branched-chain amino acids"	1	0.6875	0.805555556	1	0.19047619	0	1	0.0625
849_OG5_128663_3 - ALL (-ANIMALS)_YKL211C	YKL211C	"TRP3 - Bifunctional enzyme exhibiting both indole-3-glycerol-phosphate synthase and anthranilate synthase activities, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p"	1	0.75	0.75	1	0.095238095	0	0.95	0.125
850_OG5_129100_3 - ALL (-ANIMALS)_YLR355C	YLR355C	ILV5 - Bifunctional acetohydroxyacid reductoisomerase and mtDNA binding protein; involved in branched-chain amino acid biosynthesis and maintenance of wild-type mitochondrial DNA; found in mitochondrial nucleoids	1	0.6875	0.75	1	0.142857143	0	1	0.0625
851_OG5_129302_3 - ALL (-ANIMALS)_YBR248C	YBR248C	"HIS7 - Imidazole glycerol phosphate synthase (glutamine amidotransferase:cyclase), catalyzes the fifth and sixth steps of histidine biosynthesis and also produces 5-aminoimidazole-4-carboxamide ribotide (AICAR), a purine precursor"	1	0.6875	0.722222222	1	0.19047619	0	1	0.0625
852_OG5_127864_3 - ALL (-ANIMALS)_YDR234W	YDR234W	"LYS4 - Homoaconitase, catalyzes the conversion of homocitrate to homoisocitrate, which is a step in the lysine biosynthesis pathway"	1	0.6875	0.722222222	1	0.142857143	0	1	0.0625
853_OG5_127864_3 - ALL (-ANIMALS)_YGL009C	YGL009C	"LEU1 - Isopropylmalate isomerase, catalyzes the second step in the leucine biosynthesis pathway"	1	0.6875	0.722222222	1	0.142857143	0	1	0.0625
854_OG5_129258_3 - ALL (-ANIMALS)_YOR202W	YOR202W	"HIS3 - Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p"	1	0.6875	0.75	1	0.142857143	0	0.95	0.0625
855_OG5_128612_3 - ALL (-ANIMALS)_YOL055C	YOL055C	THI20 - Multifunctional protein with hydroxymethylpyrimidine phosphate (HMP-P) kinase and thiaminase activities; involved in thiamine biosynthesis and degradation; in a gene family with THI21 and THI22; HMP-P kinase activity redundant with Thi21p	1	0.9375	0.805555556	0.625	0.142857143	0	1	0.0625
856_OG5_128612_3 - ALL (-ANIMALS)_YPL258C	YPL258C	"THI21 - Hydroxymethylpyrimidine phosphate kinase, involved in the last steps in thiamine biosynthesis; member of a gene family with THI20 and THI22; Thi20p also has this activity"	1	0.9375	0.805555556	0.625	0.142857143	0	1	0.0625
857_OG5_128612_3 - ALL (-ANIMALS)_YPR121W	YPR121W	THI22 - Protein with similarity to hydroxymethylpyrimidine phosphate kinases; member of a gene family with THI20 and THI21; not required for thiamine biosynthesis	1	0.9375	0.805555556	0.625	0.142857143	0	1	0.0625
858_OG5_129046_3 - ALL (-ANIMALS)_YBR176W	YBR176W	"ECM31 - Ketopantoate hydroxymethyltransferase, required for pantothenic acid biosynthesis, converts 2-oxoisovalerate into 2-dehydropantoate"	1	0.5	0.805555556	1	0.238095238	0	1	0.125
859_OG5_129171_3 - ALL (-ANIMALS)_YHR025W	YHR025W	"THR1 - Homoserine kinase, conserved protein required for threonine biosynthesis; expression is regulated by the GCN4-mediated general amino acid control pathway"	1	0.75	0.555555556	1	0.047619048	0	1	0.375
860_OG5_128803_3 - ALL (-ANIMALS)_YNL256W	YNL256W	"FOL1 - Multifunctional enzyme of the folic acid biosynthesis pathway, has dihydropteroate synthetase, dihydro-6-hydroxymethylpterin pyrophosphokinase, and dihydroneopterin aldolase activities"	1	0.375	0.888888889	1	0.142857143	0	1	0.25
861_OG5_127887_3 - ALL (-ANIMALS)_YIL010W	YIL010W	DOT5 - Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth	1	0.5	0.722222222	1	0.142857143	0	0.95	0.375
862_OG5_129345_3 - ALL (-ANIMALS)_YCL009C	YCL009C	"ILV6 - Regulatory subunit of acetolactate synthase, which catalyzes the first step of branched-chain amino acid biosynthesis; enhances activity of the Ilv2p catalytic subunit, localizes to mitochondria"	1	0.375	0.777777778	1	0.047619048	0	1	0.0625
863_OG5_127542_3 - ALL (-ANIMALS)_YJL092W	YJL092W	"SRS2 - DNA helicase and DNA-dependent ATPase involved in DNA repair, needed for proper timing of commitment to meiotic recombination and transition from Meiosis I to II; blocks trinucleotide repeat expansion; affects genome stability"	1	0.25	1	1	0.333333333	0	0.9	0.375
864_OG5_128715_3 - ALL (-ANIMALS)_YER091C	YER091C	"MET6 - Cobalamin-independent methionine synthase, involved in methionine biosynthesis and regeneration; requires a minimum of two glutamates on the methyltetrahydrofolate substrate, similar to bacterial metE homologs"	1	0.625	0.583333333	0.75	0.142857143	0	1	0.1875
865_OG5_129962_3 - ALL (-ANIMALS)_YPR167C	YPR167C	"MET16 - 3'-phosphoadenylsulfate reductase, reduces 3'-phosphoadenylyl sulfate to adenosine-3',5'-bisphosphate and free sulfite using reduced thioredoxin as cosubstrate, involved in sulfate assimilation and methionine metabolism"	1	0.4375	0.472222222	1	0.142857143	0	1	0.0625
866_OG5_128220_3 - ALL (-ANIMALS)_YMR178W	YMR178W	YMR178W - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced in response to the DNA-damaging agent MMS; YMR178W is not an essential gene	1	0.625	0.833333333	0.5	0.095238095	0	0.95	0.125
867_OG5_128015_3 - ALL (-ANIMALS)_YPL214C	YPL214C	"THI6 - Bifunctional enzyme with thiamine-phosphate pyrophosphorylase and 4-methyl-5-beta-hydroxyethylthiazole kinase activities, required for thiamine biosynthesis; GFP-fusion protein localizes to the cytoplasm in a punctate pattern"	1	0.375	0.777777778	0.75	0.142857143	0	1	0.0625
868_OG5_126935_3 - ALL (-ANIMALS)_YBR072W	YBR072W	"HSP26 - Small heat shock protein (sHSP) with chaperone activity; forms hollow, sphere-shaped oligomers that suppress unfolded proteins aggregation; oligomer activation requires heat-induced conformational change; also has mRNA binding activity"	1	0.5625	0.555555556	1	0.428571429	0	0.7	0.4375
869_OG5_130203_3 - ALL (-ANIMALS)_YMR062C	YMR062C	"ARG7 - Mitochondrial ornithine acetyltransferase, catalyzes the fifth step in arginine biosynthesis; also possesses acetylglutamate synthase activity, regenerates acetylglutamate while forming ornithine"	1	0.25	0.527777778	1	0.142857143	0	1	0.0625
870_OG5_128196_3 - ALL (-ANIMALS)_YJL094C	YJL094C	"KHA1 - Putative K+/H+ antiporter with a probable role in intracellular cation homeostasis, localized to Golgi vesicles and detected in highly purified mitochondria in high-throughput studies"	1	0.8125	0.361111111	0.625	0.095238095	0	0.85	0
871_OG5_130209_3 - ALL (-ANIMALS)_YDR007W	YDR007W	"TRP1 - Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA)"	1	0.625	0.527777778	1	0.142857143	0	0.4	0
872_OG5_128068_3 - ALL (-ANIMALS)_YNR058W	YNR058W	"BIO3 - 7,8-diamino-pelargonic acid aminotransferase (DAPA), catalyzes the second step in the biotin biosynthesis pathway; BIO3 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis"	1	0.3125	0.722222222	0.5	0.238095238	0	0.85	0.0625
873_OG5_130208_3 - ALL (-ANIMALS)_YHR063C	YHR063C	"PAN5 - 2-dehydropantoate 2-reductase, part of the pantothenic acid pathway, structurally homologous to E. coli panE"	1	0.4375	0.388888889	0.5	0.047619048	0	1	0.125
874_OG5_128273_3 - ALL (-ANIMALS)_YJL218W	YJL218W	"YJL218W - Putative protein of unknown function, similar to bacterial galactoside O-acetyltransferases; induced by oleate in an OAF1/PIP2-dependent manner; promoter contains an oleate response element consensus sequence; non-essential gene"	1	0.4375	0.527777778	0.5	0.142857143	0	0.8	0.125
875_OG5_130587_3 - ALL (-ANIMALS)_YJR010W	YJR010W	"MET3 - ATP sulfurylase, catalyzes the primary step of intracellular sulfate activation, essential for assimilatory reduction of sulfate to sulfide, involved in methionine metabolism"	1	0.5	0.222222222	0.5	0.19047619	0	1	0.125
876_OG5_130839_3 - ALL (-ANIMALS)_YLR303W	YLR303W	"MET17 - Methionine and cysteine synthase (O-acetyl homoserine-O-acetyl serine sulfhydrylase), required for sulfur amino acid synthesis"	1	0.25	0.5	0.25	0.095238095	0	0.9	0
877_OG5_129978_3 - ALL (-ANIMALS)_YFL050C	YFL050C	ALR2 - Probable Mg(2+) transporter; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions; plays a role in regulating Ty1 transposition	1	0.3125	0.472222222	0.25	0.19047619	0	0.8	0.0625
878_OG5_129978_3 - ALL (-ANIMALS)_YOL130W	YOL130W	"ALR1 - Plasma membrane Mg(2+) transporter, expression and turnover are regulated by Mg(2+) concentration; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions"	1	0.3125	0.472222222	0.25	0.19047619	0	0.8	0.0625
879_OG5_131377_3 - ALL (-ANIMALS)_YPR201W	YPR201W	ARR3 - Plasma membrane metalloid/H+ antiporter; transports arsenite and antimonite; required for resistance to arsenic compounds; transcription is activated by Arr1p in the presence of arsenite	1	0.3125	0.277777778	0.25	0.142857143	0	0.85	0.0625
880_OG5_132591_3 - ALL (-ANIMALS)_YPR002W	YPR002W	"PDH1 - Mitochondrial protein that participates in respiration, induced by diauxic shift; homologous to E. coli PrpD, may take part in the conversion of 2-methylcitrate to 2-methylisocitrate"	1	0.25	0.222222222	0.25	0.142857143	0	0.7	0.125
881_OG5_126761_4 - EUKARYOTES_YNL189W	YNL189W	"SRP1 - Karyopherin alpha homolog, forms a dimer with karyopherin beta Kap95p to mediate import of nuclear proteins, binds the nuclear localization signal of the substrate during import; may also play a role in regulation of protein degradation"	1	0	0.027777778	1	1	1	1	0.875
882_OG5_127705_4 - EUKARYOTES_YOR157C	YOR157C	PUP1 - Beta 2 subunit of the 20S proteasome; endopeptidase with trypsin-like activity that cleaves after basic residues; synthesized as a proprotein before being proteolytically processed for assembly into 20S particle; human homolog is subunit Z	1	0.1875	0	1	1	1	1	1
883_OG5_126821_4 - EUKARYOTES_YER133W	YER133W	"GLC7 - Type 1 serine/threonine protein phosphatase catalytic subunit, involved in many processes (eg: glycogen metabolism, sporulation, mitosis); accumulates at mating projections by interaction with Afr1p; interacts with many regulatory subunits"	1	0.0625	0	1	1	1	1	1
884_OG5_127832_4 - EUKARYOTES_YDL143W	YDL143W	"CCT4 - Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo"	1	0.0625	0	1	1	1	1	1
885_OG5_126569_4 - EUKARYOTES_YBR010W	YBR010W	"HHT1 - Histone H3, core histone protein required for chromatin assembly, part of heterochromatin-mediated telomeric and HM silencing; one of two identical histone H3 proteins (see HHT2); regulated by acetylation, methylation, and phosphorylation"	1	0	0	1	1	1	1	0.9375
886_OG5_126569_4 - EUKARYOTES_YNL031C	YNL031C	"HHT2 - Histone H3, core histone protein required for chromatin assembly, part of heterochromatin-mediated telomeric and HM silencing; one of two identical histone H3 proteins (see HHT1); regulated by acetylation, methylation, and phosphorylation"	1	0	0	1	1	1	1	0.9375
887_OG5_126572_4 - EUKARYOTES_YDR224C	YDR224C	"HTB1 - Histone H2B, core histone protein required for chromatin assembly and chromosome function; nearly identical to HTB2; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation"	1	0	0	1	1	1	1	0.9375
888_OG5_126572_4 - EUKARYOTES_YBL002W	YBL002W	"HTB2 - Histone H2B, core histone protein required for chromatin assembly and chromosome function; nearly identical to HTB1; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation"	1	0	0	1	1	1	1	0.9375
889_OG5_126573_4 - EUKARYOTES_YBR009C	YBR009C	"HHF1 - Histone H4, core histone protein required for chromatin assembly and chromosome function; one of two identical histone proteins (see also HHF2); contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity"	1	0	0	1	1	1	1	0.875
890_OG5_126573_4 - EUKARYOTES_YNL030W	YNL030W	"HHF2 - Histone H4, core histone protein required for chromatin assembly and chromosome function; one of two identical histone proteins (see also HHF1); contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity"	1	0	0	1	1	1	1	0.875
891_OG5_126605_4 - EUKARYOTES_YML124C	YML124C	"TUB3 - Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; expressed at lower level than Tub1p"	1	0	0	1	1	1	1	1
892_OG5_126605_4 - EUKARYOTES_YML085C	YML085C	"TUB1 - Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules"	1	0	0	1	1	1	1	1
893_OG5_126611_4 - EUKARYOTES_YFL037W	YFL037W	"TUB2 - Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules"	1	0	0	1	1	1	1	1
894_OG5_126649_4 - EUKARYOTES_YGR108W	YGR108W	"CLB1 - B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome"	1	0	0	1	1	1	1	0.625
895_OG5_126649_4 - EUKARYOTES_YPR119W	YPR119W	"CLB2 - B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome"	1	0	0	1	1	1	1	0.625
896_OG5_126649_4 - EUKARYOTES_YGR109C	YGR109C	CLB6 - B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1	1	0	0	1	1	1	1	0.625
897_OG5_126649_4 - EUKARYOTES_YDL155W	YDL155W	"CLB3 - B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation"	1	0	0	1	1	1	1	0.625
898_OG5_126649_4 - EUKARYOTES_YLR210W	YLR210W	"CLB4 - B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation"	1	0	0	1	1	1	1	0.625
899_OG5_126655_4 - EUKARYOTES_YDR477W	YDR477W	"SNF1 - AMP-activated serine/threonine protein kinase found in a complex containing Snf4p and members of the Sip1p/Sip2p/Gal83p family; required for transcription of glucose-repressed genes, thermotolerance, sporulation, and peroxisome biogenesis"	1	0	0	1	1	1	1	0.8125
900_OG5_126655_4 - EUKARYOTES_YKL101W	YKL101W	"HSL1 - Nim1p-related protein kinase that regulates the morphogenesis and septin checkpoints; associates with the assembled septin filament; required along with Hsl7p for bud neck recruitment, phosphorylation, and degradation of Swe1p"	1	0	0	1	1	1	1	0.8125
901_OG5_126655_4 - EUKARYOTES_YDR507C	YDR507C	"GIN4 - Protein kinase involved in bud growth and assembly of the septin ring, proposed to have kinase-dependent and kinase-independent activities; undergoes autophosphorylation; similar to Kcc4p and Hsl1p"	1	0	0	1	1	1	1	0.8125
902_OG5_126655_4 - EUKARYOTES_YCL024W	YCL024W	"KCC4 - Protein kinase of the bud neck involved in the septin checkpoint, associates with septin proteins, negatively regulates Swe1p by phosphorylation, shows structural homology to bud neck kinases Gin4p and Hsl1p"	1	0	0	1	1	1	1	0.8125
903_OG5_126712_4 - EUKARYOTES_YPL031C	YPL031C	"PHO85 - Cyclin-dependent kinase, with ten cyclin partners; involved in regulating the cellular response to nutrient levels and environmental conditions and progression through the cell cycle"	1	0	0	1	1	1	1	1
904_OG5_126712_4 - EUKARYOTES_YBR160W	YBR160W	CDC28 - Catalytic subunit of the main cell cycle cyclin-dependent kinase (CDK); alternately associates with G1 cyclins (CLNs) and G2/M cyclins (CLBs) which direct the CDK to specific substrates	1	0	0	1	1	1	1	1
905_OG5_126888_4 - EUKARYOTES_YMR139W	YMR139W	RIM11 - Protein kinase required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta	1	0	0	1	1	1	1	0.875
906_OG5_126888_4 - EUKARYOTES_YDL079C	YDL079C	MRK1 - Glycogen synthase kinase 3 (GSK-3) homolog; one of four GSK-3 homologs in S. cerevisiae that function to activate Msn2p-dependent transcription of stress responsive genes and that function in protein degradation	1	0	0	1	1	1	1	0.875
907_OG5_127130_4 - EUKARYOTES_YMR242C	YMR242C	"RPL20A - Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl20Bp and has similarity to rat L18a ribosomal protein"	1	0	0	1	1	1	1	1
908_OG5_127130_4 - EUKARYOTES_YOR312C	YOR312C	"RPL20B - Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl20Ap and has similarity to rat L18a ribosomal protein"	1	0	0	1	1	1	1	1
909_OG5_127146_4 - EUKARYOTES_YNR052C	YNR052C	"POP2 - RNase of the DEDD superfamily, subunit of the Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation"	1	0	0	1	1	1	1	0.9375
910_OG5_127160_4 - EUKARYOTES_YIL075C	YIL075C	"RPN2 - Subunit of the 26S proteasome, substrate of the N-acetyltransferase Nat1p"	1	0	0	1	1	1	1	0.875
911_OG5_127180_4 - EUKARYOTES_YHR193C	YHR193C	"EGD2 - Alpha subunit of the heteromeric nascent polypeptide-associated complex (NAC) involved in protein sorting and translocation, associated with cytoplasmic ribosomes"	1	0	0	1	1	1	1	0.9375
912_OG5_127206_4 - EUKARYOTES_YLR448W	YLR448W	"RPL6B - Protein component of the large (60S) ribosomal subunit, has similarity to Rpl6Ap and to rat L6 ribosomal protein; binds to 5.8S rRNA"	1	0	0	1	1	1	1	0.875
913_OG5_127206_4 - EUKARYOTES_YML073C	YML073C	"RPL6A - N-terminally acetylated protein component of the large (60S) ribosomal subunit, has similarity to Rpl6Bp and to rat L6 ribosomal protein; binds to 5.8S rRNA"	1	0	0	1	1	1	1	0.875
914_OG5_127428_4 - EUKARYOTES_YDR188W	YDR188W	"CCT6 - Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, essential protein that is required for the assembly of actin and tubulins in vivo; contains an ATP-binding motif"	1	0	0	1	1	1	1	1
915_OG5_127499_4 - EUKARYOTES_YJL115W	YJL115W	"ASF1 - Nucleosome assembly factor, involved in chromatin assembly and disassembly, anti-silencing protein that causes derepression of silent loci when overexpressed; plays a role in regulating Ty1 transposition"	1	0	0	1	1	1	1	1
916_OG5_127514_4 - EUKARYOTES_YLR293C	YLR293C	"GSP1 - Ran GTPase, GTP binding protein (mammalian Ranp homolog) involved in the maintenance of nuclear organization, RNA processing and transport; regulated by Srm1p, Rna1p, Yrb1p, Yrb2p, Yrp4p, Yrb30p, Cse1p and Kap95p; yeast Gsp2p homolog"	1	0	0	1	1	1	1	1
917_OG5_127514_4 - EUKARYOTES_YOR185C	YOR185C	"GSP2 - GTP binding protein (mammalian Ranp homolog) involved in the maintenance of nuclear organization, RNA processing and transport; interacts with Kap121p, Kap123p and Pdr6p (karyophilin betas); Gsp1p homolog that is not required for viability"	1	0	0	1	1	1	1	1
918_OG5_127761_4 - EUKARYOTES_YER094C	YER094C	PUP3 - Beta 3 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit C10	1	0	0	1	1	1	1	0.9375
919_OG5_127790_4 - EUKARYOTES_YPL217C	YPL217C	"BMS1 - GTPase required for synthesis of 40S ribosomal subunits and for processing the 35S pre-rRNA at sites A0, A1, and A2; interacts with Rcl1p, which stimulates its GTPase and U3 snoRNA binding activities; has similarity to Tsr1p"	1	0	0	1	1	1	1	0.9375
920_OG5_127884_4 - EUKARYOTES_YMR314W	YMR314W	PRE5 - Alpha 6 subunit of the 20S proteasome	1	0	0	1	1	1	1	0.875
921_OG5_127914_4 - EUKARYOTES_YHR122W	YHR122W	"YHR122W - Protein of unknown function required for establishment of sister chromatid cohesion; synthetically lethal with RFC5, an RF-C subunit that links replication to cohesion establishment; YHR122W is an essential gene"	1	0	0	1	1	1	1	0.875
922_OG5_127933_4 - EUKARYOTES_YOR261C	YOR261C	"RPN8 - Essential, non-ATPase regulatory subunit of the 26S proteasome; has similarity to the human p40 proteasomal subunit and to another S. cerevisiae regulatory subunit, Rpn11p"	1	0	0	1	1	1	1	0.9375
923_OG5_128005_4 - EUKARYOTES_YGL130W	YGL130W	"CEG1 - Alpha (guanylyltransferase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CET1, an RNA 5'-triphosphatase) involved in adding the 5' cap to mRNA; the mammalian enzyme is a single bifunctional polypeptide"	1	0	0	1	1	1	1	0.8125
924_OG5_128058_4 - EUKARYOTES_YGR145W	YGR145W	"ENP2 - Essential nucleolar protein, required for biogenesis of the small ribosomal subunit; contains WD repeats, interacts with Mpp10p and Bfr2p, and has homology to Spb1p"	1	0	0	1	1	1	1	0.9375
925_OG5_128119_4 - EUKARYOTES_YLR222C	YLR222C	"UTP13 - Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA"	1	0	0	1	1	1	1	0.8125
926_OG5_126601_4 - EUKARYOTES_YIL009W	YIL009W	"FAA3 - Long chain fatty acyl-CoA synthetase, activates imported fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery"	1	0.0625	0.194444444	1	0.952380952	1	1	1
927_OG5_126601_4 - EUKARYOTES_YMR246W	YMR246W	"FAA4 - Long chain fatty acyl-CoA synthetase, activates imported fatty acids with a preference for C12:0-C16:0 chain lengths; functions in long chain fatty acid import; important for survival during stationary phase; localized to lipid particles"	1	0.0625	0.194444444	1	0.952380952	1	1	1
928_OG5_126601_4 - EUKARYOTES_YOR317W	YOR317W	"FAA1 - Long chain fatty acyl-CoA synthetase, activates imported fatty acids with a preference for C12:0-C16:0 chain lengths; functions in long chain fatty acid import; accounts for most acyl-CoA synthetase activity; localized to lipid particles"	1	0.0625	0.194444444	1	0.952380952	1	1	1
929_OG5_126601_4 - EUKARYOTES_YER015W	YER015W	"FAA2 - Medium chain fatty acyl-CoA synthetase, activates imported fatty acids; accepts a wide range of fatty acid chain lengths with a preference for medium chains, C9:0-C13:0; localized to the peroxisome"	1	0.0625	0.194444444	1	0.952380952	1	1	1
930_OG5_127765_4 - EUKARYOTES_YBR087W	YBR087W	"RFC5 - Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon"	1	0.125	0.027777778	1	0.952380952	1	1	1
931_OG5_127828_4 - EUKARYOTES_YOR259C	YOR259C	RPT4 - One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in degradation of ubiquitinated substrates; contributes preferentially to ERAD; required for spindle pole body duplication; mainly nuclear localization	1	0.125	0.027777778	1	0.952380952	1	1	0.875
932_OG5_128097_4 - EUKARYOTES_YPR051W	YPR051W	MAK3 - Catalytic subunit of N-terminal acetyltransferase of the NatC type; required for replication of dsRNA virus	1	0.125	0.027777778	1	0.952380952	1	1	0.625
933_OG5_127259_4 - EUKARYOTES_YJL050W	YJL050W	"MTR4 - ATP-dependent 3'-5' RNA helicase of the Dead-box family, involved in nuclear RNA processing and degradation both as a component of the TRAMP complex and in TRAMP independent processes; has a KOW domain that shows RNA binding activity"	1	0.0625	0.083333333	1	0.952380952	1	1	1
934_OG5_126914_4 - EUKARYOTES_YDR531W	YDR531W	"CAB1 - Pantothenate kinase (ATP:D-pantothenate 4'-phosphotransferase, EC 2.7.1.33); catalyzes the first committed step in the universal biosynthetic pathway for synthesis of coenzyme A (CoA); transcriptionally regulated by Upc2p via a sterol response element"	1	0.0625	0.055555556	1	0.952380952	1	1	0.8125
935_OG5_127265_4 - EUKARYOTES_YDR062W	YDR062W	"LCB2 - Component of serine palmitoyltransferase, responsible along with Lcb1p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine"	1	0	0.111111111	1	0.952380952	1	1	0.6875
936_OG5_126886_4 - EUKARYOTES_YKL024C	YKL024C	"URA6 - Uridylate kinase, catalyzes the seventh enzymatic step in the de novo biosynthesis of pyrimidines, converting uridine monophosphate (UMP) into uridine-5'-diphosphate (UDP)"	1	0	0.083333333	1	0.952380952	1	1	1
937_OG5_126561_4 - EUKARYOTES_YKR103W	YKR103W	NFT1 - Putative transporter of the multidrug resistance-associated protein (MRP) subfamily; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds.	1	0	0.055555556	1	0.952380952	1	1	0.75
938_OG5_126561_4 - EUKARYOTES_YLL015W	YLL015W	"BPT1 - ABC type transmembrane transporter of MRP/CFTR family, found in vacuolar membrane, involved in the transport of unconjugated bilirubin and in heavy metal detoxification via glutathione conjugates, along with Ycf1p"	1	0	0.055555556	1	0.952380952	1	1	0.75
939_OG5_126561_4 - EUKARYOTES_YDR135C	YDR135C	"YCF1 - Vacuolar glutathione S-conjugate transporter of the ATP-binding cassette family, has a role in detoxifying metals such as cadmium, mercury, and arsenite; also transports unconjugated bilirubin; similar to human cystic fibrosis protein CFTR"	1	0	0.055555556	1	0.952380952	1	1	0.75
940_OG5_126561_4 - EUKARYOTES_YGR281W	YGR281W	"YOR1 - Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter mediates export of many different organic anions including oligomycin; similar to human cystic fibrosis transmembrane receptor (CFTR)"	1	0	0.055555556	1	0.952380952	1	1	0.75
941_OG5_126561_4 - EUKARYOTES_YHL035C	YHL035C	VMR1 - Vacuolar membrane protein involved in multiple drug resistance and metal sensitivity; ATP-binding cassette (ABC) family member involved in drug transport; potential Cdc28p substrate; induced under respiratory conditions	1	0	0.055555556	1	0.952380952	1	1	0.75
942_OG5_126561_4 - EUKARYOTES_YLL048C	YLL048C	YBT1 - Transporter of the ATP-binding cassette (ABC) family involved in bile acid transport; similar to mammalian bile transporters	1	0	0.055555556	1	0.952380952	1	1	0.75
943_OG5_126795_4 - EUKARYOTES_YER165W	YER165W	"PAB1 - Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G"	1	0	0.027777778	1	0.952380952	1	1	1
944_OG5_126800_4 - EUKARYOTES_YBR109C	YBR109C	"CMD1 - Calmodulin; Ca++ binding protein that regulates Ca++ independent processes (mitosis, bud growth, actin organization, endocytosis, etc.) and Ca++ dependent processes (stress-activated pathways), targets include Nuf1p, Myo2p and calcineurin"	1	0	0.027777778	1	0.952380952	1	1	0.9375
945_OG5_126828_4 - EUKARYOTES_YHR123W	YHR123W	"EPT1 - sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferase; not essential for viability"	1	0	0.027777778	1	0.952380952	1	1	0.875
946_OG5_126828_4 - EUKARYOTES_YNL130C	YNL130C	"CPT1 - Cholinephosphotransferase, required for phosphatidylcholine biosynthesis and for inositol-dependent regulation of EPT1 transcription"	1	0	0.027777778	1	0.952380952	1	1	0.875
947_OG5_126843_4 - EUKARYOTES_YCL043C	YCL043C	"PDI1 - Protein disulfide isomerase, multifunctional protein resident in the endoplasmic reticulum lumen, essential for the formation of disulfide bonds in secretory and cell-surface proteins, unscrambles non-native disulfide bonds"	1	0	0.027777778	1	0.952380952	1	1	0.9375
948_OG5_127024_4 - EUKARYOTES_YPL209C	YPL209C	"IPL1 - Aurora kinase subunit of the conserved chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), involved in regulating kinetochore-microtubule attachments; helps maintain condensed chromosomes during anaphase and early telophase"	1	0	0.027777778	1	0.952380952	1	1	0.8125
949_OG5_127529_4 - EUKARYOTES_YDL040C	YDL040C	"NAT1 - Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing"	1	0	0.027777778	1	0.952380952	1	1	0.8125
950_OG5_127781_4 - EUKARYOTES_YGR252W	YGR252W	"GCN5 - Histone acetyltransferase, acetylates N-terminal lysines on histones H2B and H3; catalytic subunit of the ADA and SAGA histone acetyltransferase complexes; founding member of the Gcn5p-related N-acetyltransferase superfamily"	1	0	0.027777778	1	0.952380952	1	1	0.8125
951_OG5_127804_4 - EUKARYOTES_YDL160C	YDL160C	"DHH1 - Cytoplasmic DExD/H-box helicase, stimulates mRNA decapping, coordinates distinct steps in mRNA function and decay, interacts with both the decapping and deadenylase complexes, may have a role in mRNA export and translation"	1	0	0.027777778	1	0.952380952	1	1	0.875
952_OG5_128088_4 - EUKARYOTES_YKL172W	YKL172W	"EBP2 - Essential protein required for the maturation of 25S rRNA and 60S ribosomal subunit assembly, localizes to the nucleolus; constituent of 66S pre-ribosomal particles"	1	0	0.027777778	1	0.952380952	1	1	0.875
953_OG5_126705_4 - EUKARYOTES_YOR270C	YOR270C	"VPH1 - Subunit a of vacuolar-ATPase V0 domain, one of two isoforms (Vph1p and Stv1p); Vph1p is located in V-ATPase complexes of the vacuole while Stv1p is located in V-ATPase complexes of the Golgi and endosomes"	1	0.1875	0	1	0.952380952	1	1	0.9375
954_OG5_126705_4 - EUKARYOTES_YMR054W	YMR054W	"STV1 - Subunit a of the vacuolar-ATPase V0 domain, one of two isoforms (Stv1p and Vph1p); Stv1p is located in V-ATPase complexes of the Golgi and endosomes while Vph1p is located in V-ATPase complexes of the vacuole"	1	0.1875	0	1	0.952380952	1	1	0.9375
955_OG5_127508_4 - EUKARYOTES_YPR173C	YPR173C	"VPS4 - AAA-ATPase involved in multivesicular body (MVB) protein sorting, ATP-bound Vps4p localizes to endosomes and catalyzes ESCRT-III disassembly and membrane release; ATPase activity is activated by Vta1p; regulates cellular sterol metabolism"	1	0.1875	0	1	0.952380952	1	1	0.75
956_OG5_127422_4 - EUKARYOTES_YBR034C	YBR034C	"HMT1 - Nuclear SAM-dependent mono- and asymmetric arginine dimethylating methyltransferase that modifies hnRNPs, including Npl3p and Hrp1p, affecting their activity and nuclear export; methylates U1 snRNP protein Snp1p and ribosomal protein Rps2p"	1	0.125	0	1	0.952380952	1	1	0.8125
957_OG5_128035_4 - EUKARYOTES_YLR291C	YLR291C	"GCD7 - Beta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression"	1	0.125	0	1	0.952380952	1	1	0.6875
958_OG5_126696_4 - EUKARYOTES_YDL192W	YDL192W	"ARF1 - ADP-ribosylation factor, GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; functionally interchangeable with Arf2p"	1	0.0625	0	1	0.952380952	1	1	0.875
959_OG5_126696_4 - EUKARYOTES_YDL137W	YDL137W	"ARF2 - ADP-ribosylation factor, GTPase of the Ras superfamily involved in regulation of coated formation vesicles in intracellular trafficking within the Golgi; functionally interchangeable with Arf1p"	1	0.0625	0	1	0.952380952	1	1	0.875
960_OG5_127616_4 - EUKARYOTES_YML001W	YML001W	"YPT7 - Rab family GTPase; GTP-binding protein of the rab family; required for homotypic fusion event in vacuole inheritance, for endosome-endosome fusion, similar to mammalian Rab7"	1	0.0625	0	1	0.952380952	1	1	0.75
961_OG5_127786_4 - EUKARYOTES_YOR117W	YOR117W	RPT5 - One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; recruited to the GAL1-10 promoter region upon induction of transcription; similar to human TBP1	1	0.0625	0	1	0.952380952	1	1	1
962_OG5_128259_4 - EUKARYOTES_YKL149C	YKL149C	"DBR1 - RNA lariat debranching enzyme, involved in intron turnover; required for efficient Ty1 transposition"	1	0.0625	0	1	0.952380952	1	1	0.8125
963_OG5_126570_4 - EUKARYOTES_YDR225W	YDR225W	"HTA1 - Histone H2A, core histone protein required for chromatin assembly and chromosome function; one of two nearly identical subtypes (see also HTA2); DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p"	1	0	0	1	0.952380952	1	1	0.8125
964_OG5_126570_4 - EUKARYOTES_YBL003C	YBL003C	"HTA2 - Histone H2A, core histone protein required for chromatin assembly and chromosome function; one of two nearly identical (see also HTA1) subtypes; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p"	1	0	0	1	0.952380952	1	1	0.8125
965_OG5_126588_4 - EUKARYOTES_YLL024C	YLL024C	"SSA2 - ATP binding protein involved in protein folding and vacuolar import of proteins; member of heat shock protein 70 (HSP70) family; associated with the chaperonin-containing T-complex; present in the cytoplasm, vacuolar membrane and cell wall"	1	0	0	1	0.952380952	1	1	1
966_OG5_126588_4 - EUKARYOTES_YER103W	YER103W	SSA4 - Heat shock protein that is highly induced upon stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the HSP70 family; cytoplasmic protein that concentrates in nuclei upon starvation	1	0	0	1	0.952380952	1	1	1
967_OG5_126588_4 - EUKARYOTES_YAL005C	YAL005C	"SSA1 - ATPase involved in protein folding and nuclear localization signal (NLS)-directed nuclear transport; member of heat shock protein 70 (HSP70) family; forms a chaperone complex with Ydj1p; localized to the nucleus, cytoplasm, and cell wall"	1	0	0	1	0.952380952	1	1	1
968_OG5_126588_4 - EUKARYOTES_YDL229W	YDL229W	"SSB1 - Cytoplasmic ATPase that is a ribosome-associated molecular chaperone, functions with J-protein partner Zuo1p; may be involved in folding of newly-made polypeptide chains; member of the HSP70 family; interacts with phosphatase subunit Reg1p"	1	0	0	1	0.952380952	1	1	1
969_OG5_126588_4 - EUKARYOTES_YBL075C	YBL075C	SSA3 - ATPase involved in protein folding and the response to stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm	1	0	0	1	0.952380952	1	1	1
970_OG5_126588_4 - EUKARYOTES_YJL034W	YJL034W	"KAR2 - ATPase involved in protein import into the ER, also acts as a chaperone to mediate protein folding in the ER and may play a role in ER export of soluble proteins; regulates the unfolded protein response via interaction with Ire1p"	1	0	0	1	0.952380952	1	1	1
971_OG5_126588_4 - EUKARYOTES_YNL209W	YNL209W	"SSB2 - Cytoplasmic ATPase that is a ribosome-associated molecular chaperone, functions with J-protein partner Zuo1p; may be involved in the folding of newly-synthesized polypeptide chains; member of the HSP70 family; homolog of SSB1"	1	0	0	1	0.952380952	1	1	1
972_OG5_126595_4 - EUKARYOTES_YFL039C	YFL039C	"ACT1 - Actin, structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions"	1	0	0	1	0.952380952	1	1	1
973_OG5_126600_4 - EUKARYOTES_YOL016C	YOL016C	"CMK2 - Calmodulin-dependent protein kinase; may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to Cmk1p and mammalian Cam Kinase II"	1	0	0	1	0.952380952	1	1	0.75
974_OG5_126600_4 - EUKARYOTES_YFR014C	YFR014C	"CMK1 - Calmodulin-dependent protein kinase; may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to Cmk2p and mammalian Cam Kinase II"	1	0	0	1	0.952380952	1	1	0.75
975_OG5_126610_4 - EUKARYOTES_YAL026C	YAL026C	DRS2 - Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation and endocytosis; mutations in human homolog ATP8B1 result in liver disease	1	0	0	1	0.952380952	1	1	0.875
976_OG5_126610_4 - EUKARYOTES_YDR093W	YDR093W	"DNF2 - Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase"	1	0	0	1	0.952380952	1	1	0.875
977_OG5_126610_4 - EUKARYOTES_YER166W	YER166W	"DNF1 - Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase"	1	0	0	1	0.952380952	1	1	0.875
978_OG5_126660_4 - EUKARYOTES_YKR001C	YKR001C	"VPS1 - Dynamin-like GTPase required for vacuolar sorting; also involved in actin cytoskeleton organization, endocytosis, late Golgi-retention of some proteins, regulation of peroxisome biogenesis"	1	0	0	1	0.952380952	1	1	0.875
979_OG5_126660_4 - EUKARYOTES_YLL001W	YLL001W	DNM1 - Dynamin-related GTPase required for mitochondrial fission and morphology; assembles on the cytoplasmic face of mitochondrial tubules at sites at which division will occur; also participates in endocytosis and regulating peroxisome abundance	1	0	0	1	0.952380952	1	1	0.875
980_OG5_126735_4 - EUKARYOTES_YBL052C	YBL052C	"SAS3 - Histone acetyltransferase catalytic subunit of NuA3 complex that acetylates histone H3, involved in transcriptional silencing; homolog of the mammalian MOZ proto-oncogene; mutant has aneuploidy tolerance; sas3gcn5 double mutation is lethal"	1	0	0	1	0.952380952	1	1	1
981_OG5_126735_4 - EUKARYOTES_YOR244W	YOR244W	ESA1 - Catalytic subunit of the histone acetyltransferase complex (NuA4) that acetylates four conserved internal lysines of histone H4 N-terminal tail; required for cell cycle progression and transcriptional silencing at the rDNA locus	1	0	0	1	0.952380952	1	1	1
982_OG5_126765_4 - EUKARYOTES_YGL003C	YGL003C	"CDH1 - Cell-cycle regulated activator of the anaphase-promoting complex/cyclosome (APC/C), which directs ubiquitination of cyclins resulting in mitotic exit; targets the APC/C to specific substrates including Cdc20p, Ase1p, Cin8p and Fin1p"	1	0	0	1	0.952380952	1	1	0.75
983_OG5_126765_4 - EUKARYOTES_YGL116W	YGL116W	"CDC20 - Cell-cycle regulated activator of anaphase-promoting complex/cyclosome (APC/C), which is required for metaphase/anaphase transition; directs ubiquitination of mitotic cyclins, Pds1p, and other anaphase inhibitors; potential Cdc28p substrate"	1	0	0	1	0.952380952	1	1	0.75
984_OG5_126780_4 - EUKARYOTES_YPL204W	YPL204W	"HRR25 - Protein kinase involved in regulating diverse events including vesicular trafficking, DNA repair, and chromosome segregation; binds the CTD of RNA pol II; homolog of mammalian casein kinase 1delta (CK1delta)"	1	0	0	1	0.952380952	1	1	0.9375
985_OG5_126822_4 - EUKARYOTES_YNL161W	YNL161W	"CBK1 - Serine/threonine protein kinase that regulates cell morphogenesis pathways, including cell wall biosynthesis, mating projection morphology, bipolar bud site selection; regulates SRL1 mRNA localization via phosphorylation of substrate Ssd1p"	1	0	0	1	0.952380952	1	1	0.5
986_OG5_126856_4 - EUKARYOTES_YML035C	YML035C	"AMD1 - AMP deaminase, tetrameric enzyme that catalyzes the deamination of AMP to form IMP and ammonia; may be involved in regulation of intracellular adenine nucleotide pools"	1	0	0	1	0.952380952	1	1	0.5625
987_OG5_126868_4 - EUKARYOTES_YMR183C	YMR183C	SSO2 - Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane; syntaxin homolog that is functionally redundant with Sso1p	1	0	0	1	0.952380952	1	1	0.9375
988_OG5_126868_4 - EUKARYOTES_YPL232W	YPL232W	SSO1 - Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2p; syntaxin homolog; functionally redundant with Sso2p	1	0	0	1	0.952380952	1	1	0.9375
989_OG5_126877_4 - EUKARYOTES_YBR082C	YBR082C	"UBC4 - Ubiquitin-conjugating enzyme (E2), mediates degradation of abnormal or excess proteins, including calmodulin and histone H3; interacts with many SCF ubiquitin protein ligases; component of the cellular stress response"	1	0	0	1	0.952380952	1	1	0.9375
990_OG5_126877_4 - EUKARYOTES_YDR059C	YDR059C	"UBC5 - Ubiquitin-conjugating enzyme that mediates selective degradation of short-lived, abnormal, or excess proteins, including histone H3; central component of the cellular stress response; expression is heat inducible"	1	0	0	1	0.952380952	1	1	0.9375
991_OG5_126883_4 - EUKARYOTES_YNL064C	YNL064C	YDJ1 - Type I HSP40 co-chaperone involved in regulation of the HSP90 and HSP70 functions; involved in protein translocation across membranes; member of the DnaJ family	1	0	0	1	0.952380952	1	1	1
992_OG5_126901_4 - EUKARYOTES_YOR061W	YOR061W	"CKA2 - Alpha' catalytic subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerase"	1	0	0	1	0.952380952	1	1	0.9375
993_OG5_126901_4 - EUKARYOTES_YIL035C	YIL035C	"CKA1 - Alpha catalytic subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases"	1	0	0	1	0.952380952	1	1	0.9375
994_OG5_127012_4 - EUKARYOTES_YMR022W	YMR022W	"UBC7 - Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly"	1	0	0	1	0.952380952	1	1	0.8125
995_OG5_127107_4 - EUKARYOTES_YMR216C	YMR216C	SKY1 - SR protein kinase (SRPK) involved in regulating proteins involved in mRNA metabolism and cation homeostasis; similar to human SRPK1	1	0	0	1	0.952380952	1	1	0.75
996_OG5_127118_4 - EUKARYOTES_YLL050C	YLL050C	"COF1 - Cofilin, promotes actin filament depolarization in a pH-dependent manner; binds both actin monomers and filaments and severs filaments; thought to be regulated by phosphorylation at SER4; ubiquitous and essential in eukaryotes"	1	0	0	1	0.952380952	1	1	0.625
997_OG5_127137_4 - EUKARYOTES_YMR230W	YMR230W	RPS10B - Protein component of the small (40S) ribosomal subunit; nearly identical to Rps10Ap and has similarity to rat ribosomal protein S10	1	0	0	1	0.952380952	1	1	0.8125
998_OG5_127137_4 - EUKARYOTES_YOR293W	YOR293W	RPS10A - Protein component of the small (40S) ribosomal subunit; nearly identical to Rps10Bp and has similarity to rat ribosomal protein S10	1	0	0	1	0.952380952	1	1	0.8125
999_OG5_127163_4 - EUKARYOTES_YMR276W	YMR276W	"DSK2 - Nuclear-enriched ubiquitin-like polyubiquitin-binding protein, required for spindle pole body (SPB) duplication and for transit through the G2/M phase of the cell cycle, involved in proteolysis, interacts with the proteasome"	1	0	0	1	0.952380952	1	1	1
1000_OG5_127172_4 - EUKARYOTES_YCR094W	YCR094W	CDC50 - Endosomal protein that interacts with phospholipid flippase Drs2p; interaction with Cdc50p is essential for Drs2p catalytic activity; mutations affect cell polarity and polarized growth; similar to Ynr048wp and Lem3p	1	0	0	1	0.952380952	1	1	0.75
1001_OG5_127178_4 - EUKARYOTES_YOR239W	YOR239W	ABP140 - AdoMet-dependent tRNA methyltransferase and actin binding protein; C-terminal fragment is responsible for 3-methylcytidine modification of residue 32 of the tRNA anti-codon loop of tRNA-Thr and tRNA-Ser and contains an S-adenosylmethionine (AdoMet) binding motif; N-terminal actin binding sequence interacts with actin filaments and localizes to actin patches and cables	1	0	0	1	0.952380952	1	1	0.625
1002_OG5_127256_4 - EUKARYOTES_YLR262C	YLR262C	"YPT6 - Rab family GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6"	1	0	0	1	0.952380952	1	1	0.8125
1003_OG5_127261_4 - EUKARYOTES_YOR369C	YOR369C	RPS12 - Protein component of the small (40S) ribosomal subunit; has similarity to rat ribosomal protein S12	1	0	0	1	0.952380952	1	1	0.9375
1004_OG5_127297_4 - EUKARYOTES_YNL049C	YNL049C	"SFB2 - Component of the Sec23p-Sfb2p heterodimer of the COPII vesicle coat, required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sec24p and Sfb3p"	1	0	0	1	0.952380952	1	1	0.9375
1005_OG5_127297_4 - EUKARYOTES_YIL109C	YIL109C	"SEC24 - Component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat, required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sfb2p and Sfb3p"	1	0	0	1	0.952380952	1	1	0.9375
1006_OG5_127331_4 - EUKARYOTES_YPL218W	YPL218W	"SAR1 - GTPase, GTP-binding protein of the ARF family, component of COPII coat of vesicles; required for transport vesicle formation during ER to Golgi protein transport"	1	0	0	1	0.952380952	1	1	0.9375
1007_OG5_127353_4 - EUKARYOTES_YER136W	YER136W	"GDI1 - GDP dissociation inhibitor, regulates vesicle traffic in secretory pathways by regulating the dissociation of GDP from the Sec4/Ypt/rab family of GTP binding proteins"	1	0	0	1	0.952380952	1	1	0.875
1008_OG5_127354_4 - EUKARYOTES_YJL053W	YJL053W	"PEP8 - Vacuolar protein sorting protein that forms part of the multimeric membrane-associated retromer complex along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport"	1	0	0	1	0.952380952	1	1	0.8125
1009_OG5_127368_4 - EUKARYOTES_YOR096W	YOR096W	"RPS7A - Protein component of the small (40S) ribosomal subunit, nearly identical to Rps7Bp; interacts with Kti11p; deletion causes hypersensitivity to zymocin; has similarity to rat S7 and Xenopus S8 ribosomal proteins"	1	0	0	1	0.952380952	1	1	0.8125
1010_OG5_127368_4 - EUKARYOTES_YNL096C	YNL096C	"RPS7B - Protein component of the small (40S) ribosomal subunit, nearly identical to Rps7Ap; interacts with Kti11p; deletion causes hypersensitivity to zymocin; has similarity to rat S7 and Xenopus S8 ribosomal proteins"	1	0	0	1	0.952380952	1	1	0.8125
1011_OG5_127386_4 - EUKARYOTES_YML069W	YML069W	"POB3 - Subunit of the heterodimeric FACT complex (Spt16p-Pob3p), which associates with chromatin via interaction with Nhp6Ap and Nhp6Bp, and reorganizes nucleosomes to facilitate access to DNA by RNA and DNA polymerases"	1	0	0	1	0.952380952	1	1	0.875
1012_OG5_127402_4 - EUKARYOTES_YGL043W	YGL043W	"DST1 - General transcription elongation factor TFIIS, enables RNA polymerase II to read through blocks to elongation by stimulating cleavage of nascent transcripts stalled at transcription arrest sites"	1	0	0	1	0.952380952	1	1	0.9375
1013_OG5_127430_4 - EUKARYOTES_YDR328C	YDR328C	"SKP1 - Evolutionarily conserved kinetochore protein that is part of multiple protein complexes, including the SCF ubiquitin ligase complex, the CBF3 complex that binds centromeric DNA, and the RAVE complex that regulates assembly of the V-ATPase"	1	0	0	1	0.952380952	1	1	0.8125
1014_OG5_127474_4 - EUKARYOTES_YPL259C	YPL259C	APM1 - Mu1-like medium subunit of the clathrin-associated protein complex (AP-1); binds clathrin; involved in clathrin-dependent Golgi protein sorting	1	0	0	1	0.952380952	1	1	0.8125
1015_OG5_127480_4 - EUKARYOTES_YGL206C	YGL206C	"CHC1 - Clathrin heavy chain, subunit of the major coat protein involved in intracellular protein transport and endocytosis; two heavy chains form the clathrin triskelion structural component; the light chain (CLC1) is thought to regulate function"	1	0	0	1	0.952380952	1	1	0.8125
1016_OG5_127550_4 - EUKARYOTES_YBR058C	YBR058C	"UBP14 - Ubiquitin-specific protease that specifically disassembles unanchored ubiquitin chains; involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; similar to human isopeptidase T"	1	0	0	1	0.952380952	1	1	0.9375
1017_OG5_127557_4 - EUKARYOTES_YDL132W	YDL132W	"CDC53 - Cullin, structural protein of SCF complexes (which also contain Skp1p, Cdc34p, Hrt1p and an F-box protein) involved in ubiquitination; SCF promotes the G1-S transition by targeting G1 cyclins and the Cln-CDK inhibitor Sic1p for degradation"	1	0	0	1	0.952380952	1	1	0.6875
1018_OG5_127562_4 - EUKARYOTES_YFR050C	YFR050C	PRE4 - Beta 7 subunit of the 20S proteasome	1	0	0	1	0.952380952	1	1	0.9375
1019_OG5_127597_4 - EUKARYOTES_YLR195C	YLR195C	"NMT1 - N-myristoyl transferase, catalyzes the cotranslational, covalent attachment of myristic acid to the N-terminal glycine residue of several proteins involved in cellular growth and signal transduction"	1	0	0	1	0.952380952	1	1	1
1020_OG5_127623_4 - EUKARYOTES_YGL011C	YGL011C	SCL1 - Alpha 1 subunit of the 20S proteasome involved in the degradation of ubiquitinated substrates; 20S proteasome is the core complex of the 26S proteasome; essential for growth; detected in the mitochondria	1	0	0	1	0.952380952	1	1	0.8125
1021_OG5_127648_4 - EUKARYOTES_YFL045C	YFL045C	"SEC53 - Phosphomannomutase, involved in synthesis of GDP-mannose and dolichol-phosphate-mannose; required for folding and glycosylation of secretory proteins in the ER lumen"	1	0	0	1	0.952380952	1	1	0.9375
1022_OG5_127687_4 - EUKARYOTES_YLR208W	YLR208W	"SEC13 - Component of the Nup84 nuclear pore sub-complex, the Sec13p-Sec31p complex of the COPII vesicle coat, and the SEA (Seh1-associated) complex; required for vesicle formation in ER to Golgi transport and nuclear pore complex organization"	1	0	0	1	0.952380952	1	1	0.8125
1023_OG5_127690_4 - EUKARYOTES_YFR051C	YFR051C	"RET2 - Delta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER"	1	0	0	1	0.952380952	1	1	0.8125
1024_OG5_127739_4 - EUKARYOTES_YDR092W	YDR092W	UBC13 - Ubiquitin-conjugating enzyme involved in the error-free DNA postreplication repair pathway; interacts with Mms2p to assemble ubiquitin chains at the Ub Lys-63 residue; DNA damage triggers redistribution from the cytoplasm to the nucleus	1	0	0	1	0.952380952	1	1	0.8125
1025_OG5_127754_4 - EUKARYOTES_YHR170W	YHR170W	NMD3 - Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex	1	0	0	1	0.952380952	1	1	1
1026_OG5_127779_4 - EUKARYOTES_YPR041W	YPR041W	TIF5 - Translation initiation factor eIF5; functions both as a GTPase-activating protein to mediate hydrolysis of ribosome-bound GTP and as a GDP dissociation inhibitor to prevent recycling of eIF2	1	0	0	1	0.952380952	1	1	0.875
1027_OG5_127785_4 - EUKARYOTES_YEL031W	YEL031W	"SPF1 - P-type ATPase, ion transporter of the ER membrane involved in ER function and Ca2+ homeostasis; required for regulating Hmg2p degradation; confers sensitivity to a killer toxin (SMKT) produced by Pichia farinosa KK1"	1	0	0	1	0.952380952	1	1	0.9375
1028_OG5_127822_4 - EUKARYOTES_YMR288W	YMR288W	HSH155 - U2-snRNP associated splicing factor that forms extensive associations with the branch site-3' splice site-3' exon region upon prespliceosome formation; similarity to the mammalian U2 snRNP-associated splicing factor SAP155	1	0	0	1	0.952380952	1	1	0.8125
1029_OG5_127833_4 - EUKARYOTES_YOR298C-A	YOR298C-A	MBF1 - Transcriptional coactivator that bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations	1	0	0	1	0.952380952	1	1	0.8125
1030_OG5_127889_4 - EUKARYOTES_YDL147W	YDL147W	"RPN5 - Subunit of the COP9 signalosome (CSN) and non-ATPase regulatory subunit of the 26S proteasome lid, similar to mammalian p55 subunit and to another S. cerevisiae regulatory subunit, Rpn7p; Rpn5p is an essential protein"	1	0	0	1	0.952380952	1	1	0.9375
1031_OG5_127891_4 - EUKARYOTES_YDR427W	YDR427W	"RPN9 - Non-ATPase regulatory subunit of the 26S proteasome, has similarity to putative proteasomal subunits in other species; null mutant is temperature sensitive and exhibits cell cycle and proteasome assembly defects"	1	0	0	1	0.952380952	1	1	0.875
1032_OG5_127902_4 - EUKARYOTES_YJR002W	YJR002W	"MPP10 - Component of the SSU processome and 90S preribosome, required for pre-18S rRNA processing, interacts with and controls the stability of Imp3p and Imp4p, essential for viability; similar to human Mpp10p"	1	0	0	1	0.952380952	1	1	0.9375
1033_OG5_127903_4 - EUKARYOTES_YOL077C	YOL077C	"BRX1 - Nucleolar protein, constituent of 66S pre-ribosomal particles; depletion leads to defects in rRNA processing and a block in the assembly of large ribosomal subunits; possesses a sigma(70)-like RNA-binding motif"	1	0	0	1	0.952380952	1	1	1
1034_OG5_127929_4 - EUKARYOTES_YPR010C	YPR010C	RPA135 - RNA polymerase I second largest subunit A135	1	0	0	1	0.952380952	1	1	0.9375
1035_OG5_127945_4 - EUKARYOTES_YKL045W	YKL045W	"PRI2 - Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair"	1	0	0	1	0.952380952	1	1	0.875
1036_OG5_127946_4 - EUKARYOTES_YKL080W	YKL080W	"VMA5 - Subunit C of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane"	1	0	0	1	0.952380952	1	1	0.875
1037_OG5_127957_4 - EUKARYOTES_YPR108W	YPR108W	"RPN7 - Essential, non-ATPase regulatory subunit of the 26S proteasome, similar to another S. cerevisiae regulatory subunit, Rpn5p, as well as to mammalian proteasome subunits"	1	0	0	1	0.952380952	1	1	0.875
1038_OG5_127960_4 - EUKARYOTES_YGL201C	YGL201C	MCM6 - Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex; forms a subcomplex with Mcm4p and Mcm7p	1	0	0	1	0.952380952	1	1	1
1039_OG5_127979_4 - EUKARYOTES_YLR274W	YLR274W	"MCM5 - Component of the hexameric MCM complex, which is important for priming origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation when activated by Cdc7p-Dbf4p in S-phase"	1	0	0	1	0.952380952	1	1	1
1040_OG5_128007_4 - EUKARYOTES_YDL165W	YDL165W	"CDC36 - Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor"	1	0	0	1	0.952380952	1	1	0.625
1041_OG5_128009_4 - EUKARYOTES_YGR103W	YGR103W	NOP7 - Component of several different pre-ribosomal particles; forms a complex with Ytm1p and Erb1p that is required for maturation of the large ribosomal subunit; required for exit from G<sub>0</sub> and the initiation of cell proliferation	1	0	0	1	0.952380952	1	1	0.9375
1042_OG5_128028_4 - EUKARYOTES_YOL124C	YOL124C	"TRM11 - Catalytic subunit of an adoMet-dependent tRNA methyltransferase complex (Trm11p-Trm112p), required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; contains a THUMP domain and a methyltransferase domain"	1	0	0	1	0.952380952	1	1	0.875
1043_OG5_128040_4 - EUKARYOTES_YJR068W	YJR068W	"RFC2 - Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon"	1	0	0	1	0.952380952	1	1	0.875
1044_OG5_128041_4 - EUKARYOTES_YNL288W	YNL288W	"CAF40 - Evolutionarily conserved subunit of the CCR4-NOT complex involved in controlling mRNA initiation, elongation and degradation; binds Cdc39p"	1	0	0	1	0.952380952	1	1	0.9375
1045_OG5_128052_4 - EUKARYOTES_YNL317W	YNL317W	PFS2 - Integral subunit of the pre-mRNA cleavage and polyadenylation factor (CPF) complex; plays an essential role in mRNA 3'-end formation by bridging different processing factors and thereby promoting the assembly of the processing complex	1	0	0	1	0.952380952	1	1	1
1046_OG5_128085_4 - EUKARYOTES_YGL238W	YGL238W	"CSE1 - Nuclear envelope protein that mediates the nuclear export of importin alpha (Srp1p), homolog of metazoan CAS protein, required for accurate chromosome segregation"	1	0	0	1	0.952380952	1	1	0.75
1047_OG5_128095_4 - EUKARYOTES_YPR066W	YPR066W	"UBA3 - Protein that acts together with Ula1p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation; GFP-fusion protein localizes to the cytoplasm in a punctate pattern"	1	0	0	1	0.952380952	1	1	0.8125
1048_OG5_128125_4 - EUKARYOTES_YGL195W	YGL195W	"GCN1 - Positive regulator of the Gcn2p kinase activity, forms a complex with Gcn20p; proposed to stimulate Gcn2p activation by an uncharged tRNA"	1	0	0	1	0.952380952	1	1	0.625
1049_OG5_128255_4 - EUKARYOTES_YER112W	YER112W	"LSM4 - Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA"	1	0	0	1	0.952380952	1	1	0.75
1050_OG5_128308_4 - EUKARYOTES_YJR084W	YJR084W	YJR084W - Protein that forms a complex with Thp3p; may have a role in transcription elongation and/or mRNA splicing; identified as a COP9 signalosome component but phenotype and interactions suggest it may not be involved with the signalosome	1	0	0	1	0.952380952	1	1	0.75
1051_OG5_128324_4 - EUKARYOTES_YLR272C	YLR272C	"YCS4 - Subunit of the condensin complex; required for establishment and maintenance of chromosome condensation, chromosome segregation, chromatin binding of condensin, tRNA gene clustering at the nucleolus, and silencing at the mating type locus"	1	0	0	1	0.952380952	1	1	0.4375
1052_OG5_128328_4 - EUKARYOTES_YDR486C	YDR486C	VPS60 - Cytoplasmic and vacuolar membrane protein involved in late endosome to vacuole transport; required for normal filament maturation during pseudohyphal growth; may function in targeting cargo proteins for degradation; interacts with Vta1p	1	0	0	1	0.952380952	1	1	0.4375
1053_OG5_128334_4 - EUKARYOTES_YER107C	YER107C	GLE2 - Component of the Nup82 subcomplex of the nuclear pore complex; required for polyadenylated RNA export but not for protein import; homologous to S. pombe Rae1p	1	0	0	1	0.952380952	1	1	0.875
1054_OG5_128413_4 - EUKARYOTES_YOR254C	YOR254C	"SEC63 - Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER"	1	0	0	1	0.952380952	1	1	0.6875
1055_OG5_128438_4 - EUKARYOTES_YDL216C	YDL216C	RRI1 - Catalytic subunit of the COP9 signalosome (CSN) complex that acts as an isopeptidase in cleaving the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; metalloendopeptidase involved in the adaptation to pheromone signaling	1	0	0	1	0.952380952	1	1	0.5
1056_OG5_128459_4 - EUKARYOTES_YKL019W	YKL019W	RAM2 - Alpha subunit of both the farnesyltransferase and type I geranylgeranyltransferase that catalyze prenylation of proteins containing a CAAX consensus motif; essential protein required for membrane localization of Ras proteins and a-factor	1	0	0	1	0.952380952	1	1	0.625
1057_OG5_128560_4 - EUKARYOTES_YPR144C	YPR144C	"NOC4 - Nucleolar protein, forms a complex with Nop14p that mediates maturation and nuclear export of 40S ribosomal subunits"	1	0	0	1	0.952380952	1	1	0.625
1058_OG5_128564_4 - EUKARYOTES_YLR045C	YLR045C	STU2 - Microtubule-associated protein (MAP) of the XMAP215/Dis1 family; regulates microtubule dynamics during spindle orientation and metaphase chromosome alignment; interacts with spindle pole body component Spc72p	1	0	0	1	0.952380952	1	1	0.3125
1059_OG5_128587_4 - EUKARYOTES_YOR077W	YOR077W	"RTS2 - Basic zinc-finger protein, similar to human and mouse Kin17 proteins which are chromatin-associated proteins involved in UV response and DNA replication"	1	0	0	1	0.952380952	1	1	0.625
1060_OG5_128843_4 - EUKARYOTES_YHR079C	YHR079C	IRE1 - Serine-threonine kinase and endoribonuclease; transmembrane protein that mediates the unfolded protein response (UPR) by regulating Hac1p synthesis through HAC1 mRNA splicing; Kar2p binds inactive Ire1p and releases from it upon ER stress	1	0	0	1	0.952380952	1	1	0
1061_OG5_129117_4 - EUKARYOTES_YJL109C	YJL109C	"UTP10 - Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA; mutant has increased aneuploidy tolerance"	1	0	0	1	0.952380952	1	1	0.125
1062_OG5_129453_4 - EUKARYOTES_YLR417W	YLR417W	VPS36 - Component of the ESCRT-II complex; contains the GLUE (GRAM Like Ubiquitin binding in EAP45) domain which is involved in interactions with ESCRT-I and ubiquitin-dependent sorting of proteins into the endosome	1	0	0	1	0.952380952	1	1	0.25
1063_OG5_126774_4 - EUKARYOTES_YGL173C	YGL173C	"KEM1 - Evolutionarily-conserved 5'-3' exonuclease component of cytoplasmic processing (P) bodies involved in mRNA decay; plays a role in microtubule-mediated processes, filamentous growth, ribosomal RNA maturation, and telomere maintenance"	1	0	0.027777778	1	1	1	0.95	1
1064_OG5_126774_4 - EUKARYOTES_YOR048C	YOR048C	"RAT1 - Nuclear 5' to 3' single-stranded RNA exonuclease, involved in RNA metabolism, including rRNA and snRNA processing as well as poly (A+) dependent and independent mRNA transcription termination"	1	0	0.027777778	1	1	1	0.95	1
1065_OG5_127516_4 - EUKARYOTES_YMR116C	YMR116C	ASC1 - G-protein beta subunit and guanine nucleotide dissociation inhibitor for Gpa2p; ortholog of RACK1 that inhibits translation; core component of the small (40S) ribosomal subunit; represses Gcn4p in the absence of amino acid starvation	1	0	0	1	1	1	0.95	0.875
1066_OG5_127984_4 - EUKARYOTES_YLR129W	YLR129W	"DIP2 - Nucleolar protein, specifically associated with the U3 snoRNA, part of the large ribonucleoprotein complex known as the small subunit (SSU) processome, required for 18S rRNA biogenesis, part of the active pre-rRNA processing complex"	1	0	0	1	1	1	0.95	0.875
1067_OG5_128222_4 - EUKARYOTES_YPL151C	YPL151C	"PRP46 - Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs"	1	0	0	1	1	1	0.95	0.8125
1068_OG5_127834_4 - EUKARYOTES_YBL041W	YBL041W	PRE7 - Beta 6 subunit of the 20S proteasome	1	0.125	0	1	1	0.928571429	1	0.9375
1069_OG5_127912_4 - EUKARYOTES_YNL075W	YNL075W	"IMP4 - Component of the SSU processome, which is required for pre-18S rRNA processing; interacts with Mpp10p; member of a superfamily of proteins that contain a sigma(70)-like motif and associate with RNAs"	1	0.125	0	1	1	0.928571429	1	1
1070_OG5_128003_4 - EUKARYOTES_YLR243W	YLR243W	YLR243W - Putative protein of unknown function; YLR243W is an essential gene	1	0.125	0	1	1	0.928571429	1	0.875
1071_OG5_127782_4 - EUKARYOTES_YJL111W	YJL111W	"CCT7 - Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo; mutant has increased aneuploidy tolerance"	1	0.0625	0	1	1	0.928571429	1	0.9375
1072_OG5_127236_4 - EUKARYOTES_YNL301C	YNL301C	"RPL18B - Protein component of the large (60S) ribosomal subunit, identical to Rpl18Ap and has similarity to rat L18 ribosomal protein"	1	0	0	1	1	0.928571429	1	1
1073_OG5_127236_4 - EUKARYOTES_YOL120C	YOL120C	"RPL18A - Protein component of the large (60S) ribosomal subunit, identical to Rpl18Bp and has similarity to rat L18 ribosomal protein; intron of RPL18A pre-mRNA forms stem-loop structures that are a target for Rnt1p cleavage leading to degradation"	1	0	0	1	1	0.928571429	1	1
1074_OG5_127578_4 - EUKARYOTES_YHR165C	YHR165C	"PRP8 - Component of the U4/U6-U5 snRNP complex, involved in the second catalytic step of splicing; mutations of human Prp8 cause retinitis pigmentosa"	1	0	0	1	1	0.928571429	1	0.875
1075_OG5_127698_4 - EUKARYOTES_YGR218W	YGR218W	"CRM1 - Major karyopherin, involved in export of proteins, RNAs, and ribosomal subunits from the nucleus; exportin"	1	0	0	1	1	0.928571429	1	0.9375
1076_OG5_127700_4 - EUKARYOTES_YER012W	YER012W	PRE1 - Beta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycle	1	0	0	1	1	0.928571429	1	1
1077_OG5_127757_4 - EUKARYOTES_YFR004W	YFR004W	"RPN11 - Metalloprotease subunit of the 19S regulatory particle of the 26S proteasome lid; couples the deubiquitination and degradation of proteasome substrates; involved, independent of catalytic activity, in fission of mitochondria and peroxisomes"	1	0	0	1	1	0.928571429	1	0.875
1078_OG5_127923_4 - EUKARYOTES_YJL008C	YJL008C	"CCT8 - Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo"	1	0	0	1	1	0.928571429	1	0.875
1079_OG5_127993_4 - EUKARYOTES_YNR054C	YNR054C	ESF2 - Essential nucleolar protein involved in pre-18S rRNA processing; binds to RNA and stimulates ATPase activity of Dbp8; involved in assembly of the small subunit (SSU) processome	1	0	0	1	1	0.928571429	1	0.875
1080_OG5_126574_4 - EUKARYOTES_YOL075C	YOL075C	YOL075C - Putative ABC transporter	1	0.125	0.138888889	1	0.904761905	1	1	0.75
1081_OG5_126574_4 - EUKARYOTES_YNR070W	YNR070W	"PDR18 - Putative transporter of the ATP-binding cassette (ABC) family, implicated in pleiotropic drug resistance; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"	1	0.125	0.138888889	1	0.904761905	1	1	0.75
1082_OG5_126574_4 - EUKARYOTES_YPL058C	YPL058C	"PDR12 - Plasma membrane ATP-binding cassette (ABC) transporter, weak-acid-inducible multidrug transporter required for weak organic acid resistance; induced by sorbate and benzoate and regulated by War1p; mutants exhibit sorbate hypersensitivity"	1	0.125	0.138888889	1	0.904761905	1	1	0.75
1083_OG5_126574_4 - EUKARYOTES_YDR011W	YDR011W	"SNQ2 - Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter involved in multidrug resistance and resistance to singlet oxygen species"	1	0.125	0.138888889	1	0.904761905	1	1	0.75
1084_OG5_126574_4 - EUKARYOTES_YIL013C	YIL013C	"PDR11 - ATP-binding cassette (ABC) transporter, multidrug transporter involved in multiple drug resistance; mediates sterol uptake when sterol biosynthesis is compromisedregulated by Pdr1p; required for anaerobic growth"	1	0.125	0.138888889	1	0.904761905	1	1	0.75
1085_OG5_126574_4 - EUKARYOTES_YOR011W	YOR011W	"AUS1 - Plasma membrane sterol transporter of the ATP-binding cassette family; required, along with Pdr11p, for uptake of exogenous sterols and their incorporation into the plasma membrane; activity is stimulated by phosphatidylserine; sterol uptake is required for anaerobic growth because sterol biosynthesis requires oxygen"	1	0.125	0.138888889	1	0.904761905	1	1	0.75
1086_OG5_126574_4 - EUKARYOTES_YOR328W	YOR328W	"PDR10 - ATP-binding cassette (ABC) transporter, multidrug transporter involved in the pleiotropic drug resistance network; regulated by Pdr1p and Pdr3p"	1	0.125	0.138888889	1	0.904761905	1	1	0.75
1087_OG5_126574_4 - EUKARYOTES_YDR406W	YDR406W	"PDR15 - Plasma membrane ATP binding cassette (ABC) transporter, multidrug transporter and general stress response factor implicated in cellular detoxification; regulated by Pdr1p, Pdr3p and Pdr8p; promoter contains a PDR responsive element"	1	0.125	0.138888889	1	0.904761905	1	1	0.75
1088_OG5_126574_4 - EUKARYOTES_YOR153W	YOR153W	"PDR5 - Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter actively regulated by Pdr1p; also involved in steroid transport, cation resistance, and cellular detoxification during exponential growth"	1	0.125	0.138888889	1	0.904761905	1	1	0.75
1089_OG5_127861_4 - EUKARYOTES_YER006W	YER006W	"NUG1 - GTPase that associates with nuclear 60S pre-ribosomes, required for export of 60S ribosomal subunits from the nucleus"	1	0.125	0.027777778	1	0.904761905	1	1	0.625
1090_OG5_128161_4 - EUKARYOTES_YFL017C	YFL017C	"GNA1 - Evolutionarily conserved glucosamine-6-phosphate acetyltransferase required for multiple cell cycle events including passage through START, DNA synthesis, and mitosis; involved in UDP-N-acetylglucosamine synthesis, forms GlcNAc6P from AcCoA"	1	0.0625	0.055555556	1	0.904761905	1	1	0.4375
1091_OG5_128051_4 - EUKARYOTES_YGR132C	YGR132C	"PHB1 - Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation"	1	0.0625	0.027777778	1	0.904761905	1	1	0.6875
1092_OG5_126910_4 - EUKARYOTES_YLR389C	YLR389C	"STE23 - Metalloprotease involved, with homolog Axl1p, in N-terminal processing of pro-a-factor to the mature form; expressed in both haploids and diploids; member of the insulin-degrading enzyme family"	1	0	0.194444444	1	0.904761905	1	1	0.625
1093_OG5_127651_4 - EUKARYOTES_YER163C	YER163C	YER163C - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; periodically expressed during the metabolic cycle; weak similarity to bacterial cation transport protein	1	0	0.194444444	1	0.904761905	1	1	0.25
1094_OG5_127359_4 - EUKARYOTES_YDL103C	YDL103C	"QRI1 - UDP-N-acetylglucosamine pyrophosphorylase, catalyzes the formation of UDP-N-acetylglucosamine (UDP-GlcNAc), which is important in cell wall biosynthesis, protein N-glycosylation, and GPI anchor biosynthesis"	1	0	0.083333333	1	0.904761905	1	1	1
1095_OG5_127962_4 - EUKARYOTES_YBR237W	YBR237W	"PRP5 - RNA helicase in the DEAD-box family, necessary for prespliceosome formation, bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA"	1	0	0.083333333	1	0.904761905	1	1	0.75
1096_OG5_126653_4 - EUKARYOTES_YHR176W	YHR176W	"FMO1 - Flavin-containing monooxygenase, localized to the cytoplasmic face of the ER membrane; catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide-bonded proteins"	1	0	0.055555556	1	0.904761905	1	1	0.0625
1097_OG5_126792_4 - EUKARYOTES_YDR155C	YDR155C	"CPR1 - Cytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds the drug cyclosporin A"	1	0	0.027777778	1	0.904761905	1	1	0.9375
1098_OG5_127449_4 - EUKARYOTES_YFL008W	YFL008W	"SMC1 - Subunit of the multiprotein cohesin complex, essential protein involved in chromosome segregation and in double-strand DNA break repair; SMC chromosomal ATPase family member, binds DNA with a preference for DNA with secondary structure"	1	0	0.027777778	1	0.904761905	1	1	1
1099_OG5_127744_4 - EUKARYOTES_YPR176C	YPR176C	BET2 - Beta subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p	1	0	0.027777778	1	0.904761905	1	1	0.9375
1100_OG5_128366_4 - EUKARYOTES_YNL118C	YNL118C	"DCP2 - Catalytic subunit of the Dcp1p-Dcp2p decapping enzyme complex, which removes the 5' cap structure from mRNAs prior to their degradation; member of the Nudix hydrolase family"	1	0	0.027777778	1	0.904761905	1	1	0.6875
1101_OG5_128660_4 - EUKARYOTES_YDR163W	YDR163W	"CWC15 - Non-essential protein involved in pre-mRNA splicing, component of a complex containing Cef1p; has similarity to S. pombe Cwf15p"	1	0	0.027777778	1	0.904761905	1	1	0.5625
1102_OG5_128226_4 - EUKARYOTES_YGR173W	YGR173W	RBG2 - Protein with a role in translation; forms a complex with Gir2p; has similarity to mammalian developmentally regulated GTP-binding protein	1	0.125	0	1	0.904761905	1	1	0.8125
1103_OG5_127751_4 - EUKARYOTES_YLR383W	YLR383W	"SMC6 - Protein involved in structural maintenance of chromosomes; essential subunit of Mms21-Smc5-Smc6 complex; required for growth, DNA repair, interchromosomal and sister chromatid recombination; homologous to S. pombe rad18"	1	0.0625	0	1	0.904761905	1	1	0.75
1104_OG5_128408_4 - EUKARYOTES_YDR244W	YDR244W	"PEX5 - Peroxisomal membrane signal receptor for the C-terminal tripeptide signal sequence (PTS1) of peroxisomal matrix proteins, required for peroxisomal matrix protein import; also proposed to have PTS1-receptor independent functions"	1	0.0625	0	1	0.904761905	1	1	0.375
1105_OG5_126645_4 - EUKARYOTES_YGL006W	YGL006W	PMC1 - Vacuolar Ca2+ ATPase involved in depleting cytosol of Ca2+ ions; prevents growth inhibition by activation of calcineurin in the presence of elevated concentrations of calcium; similar to mammalian PMCA1a	1	0	0	1	0.904761905	1	1	0.5625
1106_OG5_126719_4 - EUKARYOTES_YLR399C	YLR399C	BDF1 - Protein involved in transcription initiation at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal region of mammalian TAF1; redundant with Bdf2p	1	0	0	1	0.904761905	1	1	0.5
1107_OG5_126719_4 - EUKARYOTES_YDL070W	YDL070W	BDF2 - Protein involved in transcription initiation at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal region of mammalian TAF1; redundant with Bdf1p	1	0	0	1	0.904761905	1	1	0.5
1108_OG5_126741_4 - EUKARYOTES_YBL056W	YBL056W	PTC3 - Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p (see also Ptc2p) to limit maximal kinase activity induced by osmotic stress; dephosphorylates T169 phosphorylated Cdc28p (see also Ptc2p); role in DNA damage checkpoint inactivation	1	0	0	1	0.904761905	1	1	0.875
1109_OG5_126741_4 - EUKARYOTES_YER089C	YER089C	PTC2 - Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p to limit maximal osmostress induced kinase activity; dephosphorylates Ire1p to downregulate the unfolded protein response; dephosphorylates Cdc28p; inactivates the DNA damage checkpoint	1	0	0	1	0.904761905	1	1	0.875
1110_OG5_126813_4 - EUKARYOTES_YOR014W	YOR014W	RTS1 - B-type regulatory subunit of protein phosphatase 2A (PP2A); Rts1p and Cdc55p are alternative regulatory subunits for PP2A; PP2A-Rts1p protects cohesin when recruited by Sgo1p to the pericentromere; highly enriched at centromeres in absence of Cdc55p; homolog of the mammalian B' subunit of PP2A	1	0	0	1	0.904761905	1	1	0.6875
1111_OG5_126891_4 - EUKARYOTES_YKR017C	YKR017C	YKR017C - Putative protein of unknown function; contains a RING finger motif	1	0	0	1	0.904761905	1	1	0.5625
1112_OG5_126938_4 - EUKARYOTES_YLL045C	YLL045C	"RPL8B - Ribosomal protein L4 of the large (60S) ribosomal subunit, nearly identical to Rpl8Ap and has similarity to rat L7a ribosomal protein; mutation results in decreased amounts of free 60S subunits"	1	0	0	1	0.904761905	1	1	1
1113_OG5_126938_4 - EUKARYOTES_YHL033C	YHL033C	"RPL8A - Ribosomal protein L4 of the large (60S) ribosomal subunit, nearly identical to Rpl8Bp and has similarity to rat L7a ribosomal protein; mutation results in decreased amounts of free 60S subunits"	1	0	0	1	0.904761905	1	1	1
1114_OG5_126967_4 - EUKARYOTES_YNL111C	YNL111C	"CYB5 - Cytochrome b5, involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation"	1	0	0	1	0.904761905	1	1	0.5
1115_OG5_126975_4 - EUKARYOTES_YPR141C	YPR141C	"KAR3 - Minus-end-directed microtubule motor that functions in mitosis and meiosis, localizes to the spindle pole body and localization is dependent on functional Cik1p, required for nuclear fusion during mating; potential Cdc28p substrate"	1	0	0	1	0.904761905	1	1	0.5
1116_OG5_126987_4 - EUKARYOTES_YPR011C	YPR011C	"YPR011C - Putative transporter, member of the mitochondrial carrier family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"	1	0	0	1	0.904761905	1	1	0.5
1117_OG5_126987_4 - EUKARYOTES_YHR002W	YHR002W	"LEU5 - Mitochondrial carrier protein involved in the accumulation of CoA in the mitochondrial matrix; homolog of human Graves disease protein; does not encode an isozyme of Leu4p, as first hypothesized"	1	0	0	1	0.904761905	1	1	0.5
1118_OG5_126990_4 - EUKARYOTES_YLL019C	YLL019C	"KNS1 - Nonessential putative protein kinase of unknown cellular role; member of the LAMMER family of protein kinases, which are serine/threonine kinases also capable of phosphorylating tyrosine residues"	1	0	0	1	0.904761905	1	1	0.875
1119_OG5_127047_4 - EUKARYOTES_YDR107C	YDR107C	TMN2 - Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn3p; member of the evolutionarily conserved Transmembrane Nine family of proteins with nine membrane-spanning segments	1	0	0	1	0.904761905	1	1	0.5625
1120_OG5_127047_4 - EUKARYOTES_YLR083C	YLR083C	"EMP70 - Protein with a role in cellular adhesion, filamentous growth, and endosome-to-vacuole sorting; similar to Tmn2p and Tmn3p; member of Transmembrane Nine family of proteins with 9 transmembrane segments"	1	0	0	1	0.904761905	1	1	0.5625
1121_OG5_127075_4 - EUKARYOTES_YLL010C	YLL010C	"PSR1 - Plasma membrane associated protein phosphatase involved in the general stress response; required along with binding partner Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p"	1	0	0	1	0.904761905	1	1	0.9375
1122_OG5_127075_4 - EUKARYOTES_YLR019W	YLR019W	"PSR2 - Functionally redundant Psr1p homolog, a plasma membrane phosphatase involved in the general stress response; required with Psr1p and Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p"	1	0	0	1	0.904761905	1	1	0.9375
1123_OG5_127110_4 - EUKARYOTES_YIL006W	YIL006W	"YIA6 - Mitochondrial NAD+ transporter, involved in the transport of NAD+ into the mitochondria (see also YEA6); member of the mitochondrial carrier subfamily; disputed role as a pyruvate transporter; has putative mouse and human orthologs"	1	0	0	1	0.904761905	1	1	0.625
1124_OG5_127110_4 - EUKARYOTES_YIL134W	YIL134W	"FLX1 - Protein required for transport of flavin adenine dinucleotide (FAD), a synthesis product of riboflavin, across the mitochondrial membrane"	1	0	0	1	0.904761905	1	1	0.625
1125_OG5_127110_4 - EUKARYOTES_YEL006W	YEL006W	"YEA6 - Putative mitochondrial NAD+ transporter, member of the mitochondrial carrier subfamily (see also YIA6); has putative human ortholog"	1	0	0	1	0.904761905	1	1	0.625
1126_OG5_127120_4 - EUKARYOTES_YOR245C	YOR245C	"DGA1 - Diacylglycerol acyltransferase, catalyzes the terminal step of triacylglycerol (TAG) formation, acylates diacylglycerol using acyl-CoA as an acyl donor, localized to lipid particles"	1	0	0	1	0.904761905	1	1	0.5
1127_OG5_127167_4 - EUKARYOTES_YPL106C	YPL106C	SSE1 - ATPase that is a component of the heat shock protein Hsp90 chaperone complex; binds unfolded proteins; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm	1	0	0	1	0.904761905	1	1	0.8125
1128_OG5_127167_4 - EUKARYOTES_YBR169C	YBR169C	SSE2 - Member of the heat shock protein 70 (HSP70) family; may be involved in protein folding; localized to the cytoplasm; highly homologous to the heat shock protein Sse1p	1	0	0	1	0.904761905	1	1	0.8125
1129_OG5_127188_4 - EUKARYOTES_YKL059C	YKL059C	"MPE1 - Essential conserved subunit of CPF (cleavage and polyadenylation factor), plays a role in 3' end formation of mRNA via the specific cleavage and polyadenylation of pre-mRNA, contains a putative RNA-binding zinc knuckle motif"	1	0	0	1	0.904761905	1	1	0.875
1130_OG5_127220_4 - EUKARYOTES_YJR077C	YJR077C	"MIR1 - Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Pic2p but more abundant than Pic2p under normal conditions; phosphorylated"	1	0	0	1	0.904761905	1	1	0.75
1131_OG5_127220_4 - EUKARYOTES_YER053C	YER053C	"PIC2 - Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Mir1p but less abundant than Mir1p under normal conditions; expression is induced at high temperature"	1	0	0	1	0.904761905	1	1	0.75
1132_OG5_127225_4 - EUKARYOTES_YDR172W	YDR172W	"SUP35 - Translation termination factor eRF3, has a role in mRNA deadenylation and decay; altered protein conformation creates the [PSI(+)] prion that alters translational fidelity and results in a nonsense suppressor phenotype"	1	0	0	1	0.904761905	1	1	0.9375
1133_OG5_127230_4 - EUKARYOTES_YER016W	YER016W	BIM1 - Microtubule-binding protein that together with Kar9p makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally	1	0	0	1	0.904761905	1	1	0.75
1134_OG5_127279_4 - EUKARYOTES_YBL040C	YBL040C	"ERD2 - HDEL receptor, an integral membrane protein that binds to the HDEL motif in proteins destined for retention in the endoplasmic reticulum; has a role in maintenance of normal levels of ER-resident proteins"	1	0	0	1	0.904761905	1	1	0.9375
1135_OG5_127299_4 - EUKARYOTES_YBL091C-A	YBL091C-A	SCS22 - Protein involved in regulation of phospholipid metabolism; homolog of Scs2p; similar to D. melanogaster inturned protein	1	0	0	1	0.904761905	1	1	0.5625
1136_OG5_127299_4 - EUKARYOTES_YER120W	YER120W	"SCS2 - Integral ER membrane protein that regulates phospholipid metabolism via an interaction with the FFAT motif of Opi1p, also involved in telomeric silencing, disruption causes inositol auxotrophy above 34 degrees C, VAP homolog"	1	0	0	1	0.904761905	1	1	0.5625
1137_OG5_127310_4 - EUKARYOTES_YFL038C	YFL038C	"YPT1 - Rab family GTPase, involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p)"	1	0	0	1	0.904761905	1	1	0.9375
1138_OG5_127319_4 - EUKARYOTES_YPR029C	YPR029C	"APL4 - Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport"	1	0	0	1	0.904761905	1	1	0.8125
1139_OG5_127320_4 - EUKARYOTES_YEL037C	YEL037C	"RAD23 - Protein with ubiquitin-like N terminus, subunit of Nuclear Excision Repair Factor 2 (NEF2) with Rad4p that binds damaged DNA; enhances protein deglycosylation activity of Png1p; also involved, with Rad4p, in ubiquitylated protein turnover"	1	0	0	1	0.904761905	1	1	0.8125
1140_OG5_127321_4 - EUKARYOTES_YFL005W	YFL005W	SEC4 - Rab family GTPase essential for vesicle-mediated exocytic secretion and autophagy; associates with the exocyst component Sec15p and may regulate polarized delivery of transport vesicles to the exocyst at the plasma membrane	1	0	0	1	0.904761905	1	1	0.125
1141_OG5_127323_4 - EUKARYOTES_YJL097W	YJL097W	"PHS1 - Essential 3-hydroxyacyl-CoA dehydratase of the ER membrane, involved in elongation of very long-chain fatty acids; evolutionarily conserved, similar to mammalian PTPLA and PTPLB; involved in sphingolipid biosynthesis and protein trafficking"	1	0	0	1	0.904761905	1	1	0.75
1142_OG5_127384_4 - EUKARYOTES_YNL244C	YNL244C	SUI1 - Translation initiation factor eIF1; component of a complex involved in recognition of the initiator codon; modulates translation accuracy at the initiation phase	1	0	0	1	0.904761905	1	1	0.8125
1143_OG5_127452_4 - EUKARYOTES_YDR304C	YDR304C	"CPR5 - Peptidyl-prolyl cis-trans isomerase (cyclophilin) of the endoplasmic reticulum, catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; transcriptionally induced in response to unfolded proteins in the ER"	1	0	0	1	0.904761905	1	1	0.625
1144_OG5_127452_4 - EUKARYOTES_YHR057C	YHR057C	"CPR2 - Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; has a potential role in the secretory pathway"	1	0	0	1	0.904761905	1	1	0.625
1145_OG5_127506_4 - EUKARYOTES_YDL195W	YDL195W	"SEC31 - Component of the Sec13p-Sec31p complex of the COPII vesicle coat, required for vesicle formation in ER to Golgi transport; mutant has increased aneuploidy tolerance"	1	0	0	1	0.904761905	1	1	0.8125
1146_OG5_127540_4 - EUKARYOTES_YDR170C	YDR170C	"SEC7 - Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors involved in proliferation of the Golgi, intra-Golgi transport and ER-to-Golgi transport; found in the cytoplasm and on Golgi-associated coated vesicles"	1	0	0	1	0.904761905	1	1	0.375
1147_OG5_127560_4 - EUKARYOTES_YDR105C	YDR105C	"TMS1 - Vacuolar membrane protein of unknown function that is conserved in mammals; predicted to contain eleven transmembrane helices; interacts with Pdr5p, a protein involved in multidrug resistance"	1	0	0	1	0.904761905	1	1	0.3125
1148_OG5_127608_4 - EUKARYOTES_YNL287W	YNL287W	"SEC21 - Gamma subunit of coatomer, a heptameric protein complex that together with Arf1p forms the COPI coat; involved in ER to Golgi transport of selective cargo"	1	0	0	1	0.904761905	1	1	0.875
1149_OG5_127643_4 - EUKARYOTES_YBR017C	YBR017C	KAP104 - Transportin or cytosolic karyopherin beta 2; functions in the rg-nuclear localization signal-mediated nuclear import/reimport of mRNA-binding proteins Nab2p and Hrp1p; regulates asymmetric protein synthesis in daughter cells during mitosis	1	0	0	1	0.904761905	1	1	0.6875
1150_OG5_127683_4 - EUKARYOTES_YLR447C	YLR447C	"VMA6 - Subunit d of the five-subunit V0 integral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found in the endomembrane system; stabilizes VO subunits; required for V1 domain assembly on the vacuolar membrane"	1	0	0	1	0.904761905	1	1	0.9375
1151_OG5_127692_4 - EUKARYOTES_YKL196C	YKL196C	"YKT6 - Vesicle membrane protein (v-SNARE) with acyltransferase activity; involved in trafficking to and within the Golgi, endocytic trafficking to the vacuole, and vacuolar fusion; membrane localization due to prenylation at the carboxy-terminus"	1	0	0	1	0.904761905	1	1	1
1152_OG5_127721_4 - EUKARYOTES_YGR278W	YGR278W	CWC22 - Spliceosome-associated protein that is required for pre-mRNA splicing; necessary for Prp2p function at the first catalytic step of splicing; has similarity to S. pombe Cwf22p; CWC22 is an essential protein	1	0	0	1	0.904761905	1	1	0.8125
1153_OG5_127797_4 - EUKARYOTES_YPR036W	YPR036W	"VMA13 - Subunit H of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; serves as an activator or a structural stabilizer of the V-ATPase"	1	0	0	1	0.904761905	1	1	0.875
1154_OG5_127856_4 - EUKARYOTES_YDR189W	YDR189W	SLY1 - Hydrophilic protein involved in vesicle trafficking between the ER and Golgi; SM (Sec1/Munc-18) family protein that binds the tSNARE Sed5p and stimulates its assembly into a trans-SNARE membrane-protein complex	1	0	0	1	0.904761905	1	1	0.9375
1155_OG5_127871_4 - EUKARYOTES_YGL099W	YGL099W	LSG1 - Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm	1	0	0	1	0.904761905	1	1	1
1156_OG5_127911_4 - EUKARYOTES_YAL021C	YAL021C	"CCR4 - Component of the CCR4-NOT transcriptional complex, which is involved in regulation of gene expression; component of the major cytoplasmic deadenylase, which is involved in mRNA poly(A) tail shortening"	1	0	0	1	0.904761905	1	1	0.5625
1157_OG5_127938_4 - EUKARYOTES_YGR257C	YGR257C	"MTM1 - Mitochondrial protein of the mitochondrial carrier family, involved in activating mitochondrial Sod2p probably by facilitating insertion of an essential manganese cofactor"	1	0	0	1	0.904761905	1	1	0.5
1158_OG5_127954_4 - EUKARYOTES_YPL020C	YPL020C	ULP1 - Protease that specifically cleaves Smt3p protein conjugates; required for cell cycle progression; associates with nucleoporins and may interact with septin rings during telophase; sequestered to the nucleolus under stress conditions	1	0	0	1	0.904761905	1	1	0.6875
1159_OG5_127969_4 - EUKARYOTES_YMR224C	YMR224C	"MRE11 - Subunit of a complex with Rad50p and Xrs2p (MRX complex) that functions in repair of DNA double-strand breaks and in telomere stability, exhibits nuclease activity that appears to be required for MRX function; widely conserved"	1	0	0	1	0.904761905	1	1	0.9375
1160_OG5_127990_4 - EUKARYOTES_YKL009W	YKL009W	"MRT4 - Protein involved in mRNA turnover and ribosome assembly, localizes to the nucleolus"	1	0	0	1	0.904761905	1	1	0.875
1161_OG5_128000_4 - EUKARYOTES_YMR213W	YMR213W	"CEF1 - Essential splicing factor; associated with Prp19p and the spliceosome, contains an N-terminal c-Myb DNA binding motif necessary for cell viability but not for Prp19p association, evolutionarily conserved and homologous to S. pombe Cdc5p"	1	0	0	1	0.904761905	1	1	0.875
1162_OG5_128001_4 - EUKARYOTES_YNL082W	YNL082W	"PMS1 - ATP-binding protein required for mismatch repair in mitosis and meiosis; functions as a heterodimer with Mlh1p, binds double- and single-stranded DNA via its N-terminal domain, similar to E. coli MutL"	1	0	0	1	0.904761905	1	1	0.9375
1163_OG5_128038_4 - EUKARYOTES_YJL133W	YJL133W	"MRS3 - Iron transporter that mediates Fe2+ transport across the inner mitochondrial membrane; mitochondrial carrier family member, similar to and functionally redundant with Mrs4p; active under low-iron conditions; may transport other cations"	1	0	0	1	0.904761905	1	1	0.625
1164_OG5_128038_4 - EUKARYOTES_YKR052C	YKR052C	"MRS4 - Iron transporter that mediates Fe2+ transport across the inner mitochondrial membrane; mitochondrial carrier family member, similar to and functionally redundant with Mrs3p; active under low-iron conditions; may transport other cations"	1	0	0	1	0.904761905	1	1	0.625
1165_OG5_128043_4 - EUKARYOTES_YCR063W	YCR063W	BUD31 - Component of the SF3b subcomplex of the U2 snRNP; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern	1	0	0	1	0.904761905	1	1	0.875
1166_OG5_128090_4 - EUKARYOTES_YLR117C	YLR117C	"CLF1 - Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; homolog of Drosophila crooked neck protein; interacts with U1 snRNP proteins"	1	0	0	1	0.904761905	1	1	0.8125
1167_OG5_128127_4 - EUKARYOTES_YCR093W	YCR093W	"CDC39 - Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor"	1	0	0	1	0.904761905	1	1	0.75
1168_OG5_128131_4 - EUKARYOTES_YOL049W	YOL049W	"GSH2 - Glutathione synthetase, catalyzes the ATP-dependent synthesis of glutathione (GSH) from gamma-glutamylcysteine and glycine; induced by oxidative stress and heat shock"	1	0	0	1	0.904761905	1	1	0.625
1169_OG5_128180_4 - EUKARYOTES_YNL092W	YNL092W	YNL092W - Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; YNL092W is not an essential gene	1	0	0	1	0.904761905	1	1	0.8125
1170_OG5_128181_4 - EUKARYOTES_YLR240W	YLR240W	VPS34 - Phosphatidylinositol 3-kinase responsible for the synthesis of phosphatidylinositol 3-phosphate; forms membrane-associated signal transduction complex with Vps15p to regulate protein sorting; activated by the GTP-bound form of Gpa1p	1	0	0	1	0.904761905	1	1	0.6875
1171_OG5_128240_4 - EUKARYOTES_YNR007C	YNR007C	"ATG3 - E2-like enzyme involved in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; plays a role in formation of Atg8p-phosphatidylethanolamine conjugates, which are involved in membrane dynamics during autophagy and Cvt"	1	0	0	1	0.904761905	1	1	0.6875
1172_OG5_128250_4 - EUKARYOTES_YDL091C	YDL091C	"UBX3 - UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p, green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern"	1	0	0	1	0.904761905	1	1	0.6875
1173_OG5_128266_4 - EUKARYOTES_YJL143W	YJL143W	"TIM17 - Essential subunit of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); with Tim23p, contributes to the architecture and function of the import channel; may link the import motor to the core TIM23 complex"	1	0	0	1	0.904761905	1	1	0.5625
1174_OG5_128285_4 - EUKARYOTES_YPR175W	YPR175W	"DPB2 - Second largest subunit of DNA polymerase II (DNA polymerase epsilon), required for normal yeast chromosomal replication; expression peaks at the G1/S phase boundary; potential Cdc28p substrate"	1	0	0	1	0.904761905	1	1	0.625
1175_OG5_128301_4 - EUKARYOTES_YJL081C	YJL081C	"ARP4 - Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes"	1	0	0	1	0.904761905	1	1	0.5
1176_OG5_128378_4 - EUKARYOTES_YGR116W	YGR116W	SPT6 - Transcription elongation factor required for the maintenance of chromatin structure during transcription in order to inhibit transcription from promoters within the coding region	1	0	0	1	0.904761905	1	1	0.5625
1177_OG5_128412_4 - EUKARYOTES_YPL003W	YPL003W	"ULA1 - Protein that acts together with Uba3p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation"	1	0	0	1	0.904761905	1	1	0.5
1178_OG5_128418_4 - EUKARYOTES_YDL153C	YDL153C	SAS10 - Essential subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit; disrupts silencing when overproduced; mutant has increased aneuploidy tolerance	1	0	0	1	0.904761905	1	1	0.75
1179_OG5_128537_4 - EUKARYOTES_YOR275C	YOR275C	RIM20 - Protein involved in proteolytic activation of Rim101p in response to alkaline pH; PalA/AIP1/Alix family member; interaction with the ESCRT-III subunit Snf7p suggests a relationship between pH response and multivesicular body formation	1	0	0	1	0.904761905	1	1	0.3125
1180_OG5_128558_4 - EUKARYOTES_YML049C	YML049C	RSE1 - Protein involved in pre-mRNA splicing; component of the pre-spliceosome; associates with U2 snRNA; involved in ER to Golgi transport	1	0	0	1	0.904761905	1	1	0.5625
1181_OG5_128598_4 - EUKARYOTES_YGR090W	YGR090W	"UTP22 - Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data"	1	0	0	1	0.904761905	1	1	0.5
1182_OG5_128601_4 - EUKARYOTES_YNL222W	YNL222W	SSU72 - Transcription/RNA-processing factor that associates with TFIIB and cleavage/polyadenylation factor Pta1p; exhibits phosphatase activity on serine-5 of the RNA polymerase II C-terminal domain; affects start site selection in vivo	1	0	0	1	0.904761905	1	1	0.1875
1183_OG5_128613_4 - EUKARYOTES_YBR055C	YBR055C	"PRP6 - Splicing factor, component of the U4/U6-U5 snRNP complex"	1	0	0	1	0.904761905	1	1	0.625
1184_OG5_128634_4 - EUKARYOTES_YNR003C	YNR003C	RPC34 - RNA polymerase III subunit C34; interacts with TFIIIB70 and is a key determinant in pol III recruitment by the preinitiation complex	1	0	0	1	0.904761905	1	1	0.75
1185_OG5_128700_4 - EUKARYOTES_YGL174W	YGL174W	"BUD13 - Subunit of the RES complex, which is required for nuclear pre-mRNA retention and splicing; involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern"	1	0	0	1	0.904761905	1	1	0.625
1186_OG5_128754_4 - EUKARYOTES_YLR002C	YLR002C	NOC3 - Protein that forms a nuclear complex with Noc2p that binds to 66S ribosomal precursors to mediate their intranuclear transport; also binds to chromatin to promote the association of DNA replication factors and replication initiation	1	0	0	1	0.904761905	1	1	0.5
1187_OG5_128816_4 - EUKARYOTES_YDL098C	YDL098C	SNU23 - Component of U4/U6.U5 snRNP involved in mRNA splicing via spliceosome	1	0	0	1	0.904761905	1	1	0.5625
1188_OG5_128825_4 - EUKARYOTES_YPR047W	YPR047W	"MSF1 - Mitochondrial phenylalanyl-tRNA synthetase, active as a monomer, unlike the cytoplasmic subunit which is active as a dimer complexed to a beta subunit dimer; similar to the alpha subunit of E. coli phenylalanyl-tRNA synthetase"	1	0	0	1	0.904761905	1	1	0.5
1189_OG5_128878_4 - EUKARYOTES_YKL022C	YKL022C	"CDC16 - Subunit of the anaphase-promoting complex/cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; required for sporulation"	1	0	0	1	0.904761905	1	1	0.375
1190_OG5_128928_4 - EUKARYOTES_YLR421C	YLR421C	RPN13 - Subunit of the 19S regulatory particle of the 26S proteasome lid; acts as a ubiquitin receptor for the proteasome; null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability	1	0	0	1	0.904761905	1	1	0.375
1191_OG5_129095_4 - EUKARYOTES_YPL012W	YPL012W	RRP12 - Protein required for export of the ribosomal subunits; associates with the RNA components of the pre-ribosomes; has a role in nuclear import in association with Pse1p; contains HEAT-repeats	1	0	0	1	0.904761905	1	1	0.375
1192_OG5_129121_4 - EUKARYOTES_YBL079W	YBL079W	"NUP170 - Subunit of the nuclear pore complex (NPC), required for NPC localization of specific nucleoporins; involved in nuclear envelope permeability and chromosome segregation; has similar to Nup157p; essential role, with Nup157p, in NPC assembly"	1	0	0	1	0.904761905	1	1	0.125
1193_OG5_129121_4 - EUKARYOTES_YER105C	YER105C	"NUP157 - Abundant subunit of the nuclear pore complex (NPC), present on both sides of the NPC; has similarity to Nup170p; essential role, with Nup170p, in NPC assembly"	1	0	0	1	0.904761905	1	1	0.125
1194_OG5_129132_4 - EUKARYOTES_YDR398W	YDR398W	UTP5 - Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit	1	0	0	1	0.904761905	1	1	0.125
1195_OG5_129137_4 - EUKARYOTES_YMR061W	YMR061W	RNA14 - Cleavage and polyadenylation factor I (CF I) component involved in cleavage and polyadenylation of mRNA 3' ends; bridges interaction between Rna15p and Hrp1p in the CF I complex	1	0	0	1	0.904761905	1	1	0.3125
1196_OG5_129170_4 - EUKARYOTES_YMR277W	YMR277W	"FCP1 - Carboxy-terminal domain (CTD) phosphatase, essential for dephosphorylation of the repeated C-terminal domain of the RNA polymerase II large subunit (Rpo21p)"	1	0	0	1	0.904761905	1	1	0.4375
1197_OG5_129199_4 - EUKARYOTES_YGR093W	YGR093W	YGR093W - Putative protein of unconfirmed function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus	1	0	0	1	0.904761905	1	1	0.4375
1198_OG5_129254_4 - EUKARYOTES_YPR025C	YPR025C	"CCL1 - Cyclin associated with protein kinase Kin28p, which is the TFIIH-associated carboxy-terminal domain (CTD) kinase involved in transcription initiation at RNA polymerase II promoters"	1	0	0	1	0.904761905	1	1	0.25
1199_OG5_129541_4 - EUKARYOTES_YGL244W	YGL244W	RTF1 - Subunit of the RNA polymerase II-associated Paf1 complex; directly or indirectly regulates DNA-binding properties of Spt15p and relative activities of different TATA elements; involved in telomere maintenance	1	0	0	1	0.904761905	1	1	0.125
1200_OG5_127263_4 - EUKARYOTES_YLR106C	YLR106C	"MDN1 - Huge dynein-related AAA-type ATPase (midasin), forms extended pre-60S particle with the Rix1 complex (Rix1p-Ipi1p-Ipi3p); acts in removal of ribosomal biogenesis factors at successive steps of pre-60S assembly and export from nucleus"	1	0.125	0.194444444	1	0.952380952	1	0.95	0.9375
1201_OG5_126850_4 - EUKARYOTES_YKR051W	YKR051W	YKR051W - Putative protein of unknown function	1	0	0.027777778	1	0.952380952	1	0.95	0.6875
1202_OG5_127587_4 - EUKARYOTES_YER027C	YER027C	"GAL83 - One of three possible beta-subunits of the Snf1 kinase complex, allows nuclear localization of the Snf1 kinase complex in the presence of a nonfermentable carbon source; contains glycogen-binding domain"	1	0	0.027777778	1	0.952380952	1	0.95	0.625
1203_OG5_127587_4 - EUKARYOTES_YGL208W	YGL208W	SIP2 - One of three beta subunits of the Snf1 serine/threonine protein kinase complex involved in the response to glucose starvation; null mutants exhibit accelerated aging; N-myristoylprotein localized to the cytoplasm and the plasma membrane	1	0	0.027777778	1	0.952380952	1	0.95	0.625
1204_OG5_127718_4 - EUKARYOTES_YMR146C	YMR146C	"TIF34 - eIF3i subunit of the core complex of translation initiation factor 3 (eIF3), which is essential for translation; stimulates rate of ribosomal scanning during translation reinitiation"	1	0	0.027777778	1	0.952380952	1	0.95	1
1205_OG5_127759_4 - EUKARYOTES_YGR135W	YGR135W	"PRE9 - Alpha 3 subunit of the 20S proteasome, the only nonessential 20S subunit; may be replaced by the alpha 4 subunit (Pre6p) under stress conditions to create a more active proteasomal isoform"	1	0.0625	0	1	0.952380952	1	0.95	0.9375
1206_OG5_127070_4 - EUKARYOTES_YKL210W	YKL210W	"UBA1 - Ubiquitin activating enzyme (E1), involved in ubiquitin-mediated protein degradation and essential for viability"	1	0	0	1	0.952380952	1	0.95	1
1207_OG5_127134_4 - EUKARYOTES_YPL249C-A	YPL249C-A	"RPL36B - Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl36Ap and has similarity to rat L36 ribosomal protein; binds to 5.8 S rRNA"	1	0	0	1	0.952380952	1	0.95	0.9375
1208_OG5_127134_4 - EUKARYOTES_YMR194W	YMR194W	"RPL36A - N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl36Bp and has similarity to rat L36 ribosomal protein; binds to 5.8 S rRNA"	1	0	0	1	0.952380952	1	0.95	0.9375
1209_OG5_127487_4 - EUKARYOTES_YBR011C	YBR011C	"IPP1 - Cytoplasmic inorganic pyrophosphatase (PPase), homodimer that catalyzes the rapid exchange of oxygens from Pi with water, highly expressed and essential for viability, active-site residues show identity to those from E. coli PPase"	1	0	0	1	0.952380952	1	0.95	0.875
1210_OG5_127496_4 - EUKARYOTES_YOL018C	YOL018C	"TLG2 - Syntaxin-like t-SNARE that forms a complex with Tlg1p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds Vps45p, which prevents Tlg2p degradation and also facilitates t-SNARE complex formation; homologous to mammalian SNARE protein syntaxin 16 (Sx16)"	1	0	0	1	0.952380952	1	0.95	0.8125
1211_OG5_127619_4 - EUKARYOTES_YDR238C	YDR238C	"SEC26 - Essential beta-coat protein of the COPI coatomer, involved in ER-to-Golgi protein trafficking and maintenance of normal ER morphology; shares 43% sequence identity with mammalian beta-coat protein (beta-COP)"	1	0	0	1	0.952380952	1	0.95	1
1212_OG5_127665_4 - EUKARYOTES_YBR080C	YBR080C	"SEC18 - ATPase required for vesicular transport between ER and Golgi, the 'priming' step in homotypic vacuole fusion, autophagy, and protein secretion; releases Sec17p from SNAP complexes; has similarity to mammalian NSF"	1	0	0	1	0.952380952	1	0.95	1
1213_OG5_127808_4 - EUKARYOTES_YDL145C	YDL145C	"COP1 - Alpha subunit of COPI vesicle coatomer complex, which surrounds transport vesicles in the early secretory pathway"	1	0	0	1	0.952380952	1	0.95	1
1214_OG5_127919_4 - EUKARYOTES_YML010W	YML010W	SPT5 - Protein involved in regulating Pol I and Pol II transcription and pre-mRNA processing; forms a complex with Spt4p; contains a C-terminal repeat domain that is a target for phosphorylation by Sgv1p	1	0	0	1	0.952380952	1	0.95	0.875
1215_OG5_128086_4 - EUKARYOTES_YGR245C	YGR245C	"SDA1 - Highly conserved nuclear protein required for actin cytoskeleton organization and passage through Start, plays a critical role in G1 events, binds Nap1p, also involved in 60S ribosome biogenesis"	1	0	0	1	0.952380952	1	0.95	0.8125
1216_OG5_128094_4 - EUKARYOTES_YCR047C	YCR047C	"BUD23 - Methyltransferase, methylates residue G1575 of 18S rRNA; required for rRNA processing and nuclear export of 40S ribosomal subunits independently of methylation activity; diploid mutant displays random budding pattern"	1	0	0	1	0.952380952	1	0.95	0.9375
1217_OG5_128096_4 - EUKARYOTES_YDL030W	YDL030W	"PRP9 - Subunit of the SF3a splicing factor complex, required for spliceosome assembly; acts after the formation of the U1 snRNP-pre-mRNA complex"	1	0	0	1	0.952380952	1	0.95	0.8125
1218_OG5_128156_4 - EUKARYOTES_YDL208W	YDL208W	"NHP2 - Nuclear protein related to mammalian high mobility group (HMG) proteins, essential for function of H/ACA-type snoRNPs, which are involved in 18S rRNA processing"	1	0	0	1	0.952380952	1	0.95	0.875
1219_OG5_128215_4 - EUKARYOTES_YOR361C	YOR361C	"PRT1 - eIF3b subunit of the core complex of translation initiation factor 3 (eIF3), essential for translation; part of a subcomplex (Prt1p-Rpg1p-Nip1p) that stimulates binding of mRNA and tRNA(i)Met to ribosomes"	1	0	0	1	0.952380952	1	0.95	0.75
1220_OG5_128251_4 - EUKARYOTES_YPR094W	YPR094W	"RDS3 - Component of the SF3b subcomplex of the U2 snRNP, zinc cluster protein involved in pre-mRNA splicing and cycloheximide resistance"	1	0	0	1	0.952380952	1	0.95	0.875
1221_OG5_128501_4 - EUKARYOTES_YNL107W	YNL107W	"YAF9 - Subunit of both the NuA4 histone H4 acetyltransferase complex and the SWR1 complex, may function to antagonize silencing near telomeres; interacts directly with Swc4p, has homology to human leukemogenic protein AF9, contains a YEATS domain"	1	0	0	1	0.952380952	1	0.95	0.6875
1222_OG5_128845_4 - EUKARYOTES_YOL145C	YOL145C	"CTR9 - Component of the Paf1p complex that binds to and modulates the activity of RNA polymerases I and II; required for expression of a subset of genes, including cyclin genes; contains TPR repeats"	1	0	0	1	0.952380952	1	0.95	0.3125
1223_OG5_128935_4 - EUKARYOTES_YDR087C	YDR087C	"RRP1 - Essential evolutionarily conserved nucleolar protein necessary for biogenesis of 60S ribosomal subunits and processing of pre-rRNAs to mature rRNAs, associated with several distinct 66S pre-ribosomal particles"	1	0	0	1	0.952380952	1	0.95	0.25
1224_OG5_127158_4 - EUKARYOTES_YLR246W	YLR246W	"ERF2 - Subunit of a palmitoyltransferase, composed of Erf2p and Shr5p, that adds a palmitoyl lipid moiety to heterolipidated substrates such as Ras1p and Ras2p through a thioester linkage; mutants partially mislocalize Ras2p to the vacuole"	1	0	0	1	1	1	0.9	0.75
1225_OG5_127906_4 - EUKARYOTES_YDR267C	YDR267C	CIA1 - WD40 repeat protein involved in assembly of cytosolic and nuclear iron-sulfur proteins; similar to the human Ciao1 protein; YDR267C is an essential gene	1	0	0	1	1	1	0.9	0.9375
1226_OG5_127936_4 - EUKARYOTES_YOR224C	YOR224C	"RPB8 - RNA polymerase subunit ABC14.5, common to RNA polymerases I, II, and III"	1	0	0	1	1	1	0.9	0.9375
1227_OG5_127606_4 - EUKARYOTES_YGL048C	YGL048C	RPT6 - One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; bound by ubiquitin-protein ligases Ubr1p and Ufd4p; localized mainly to the nucleus throughout the cell cycle	1	0.0625	0.055555556	1	0.952380952	0.928571429	1	1
1228_OG5_127538_4 - EUKARYOTES_YOL090W	YOL090W	MSH2 - Protein that forms heterodimers with Msh3p and Msh6p that bind to DNA mismatches to initiate the mismatch repair process; contains a Walker ATP-binding motif required for repair activity; Msh2p-Msh6p binds to and hydrolyzes ATP	1	0.0625	0.027777778	1	0.952380952	0.928571429	1	1
1229_OG5_127998_4 - EUKARYOTES_YDR212W	YDR212W	"TCP1 - Alpha subunit of chaperonin-containing T-complex, which mediates protein folding in the cytosol; involved in actin cytoskeleton maintenance; overexpression in neurons suppresses formation of pathogenic conformations of huntingtin protein"	1	0.0625	0.027777778	1	0.952380952	0.928571429	1	0.875
1230_OG5_127944_4 - EUKARYOTES_YDR190C	YDR190C	RVB1 - Essential protein involved in transcription regulation; component of chromatin remodeling complexes; required for assembly and function of the INO80 complex; also referred to as pontin; member of the RUVB-like protein family	1	0.1875	0	1	0.952380952	0.928571429	1	0.9375
1231_OG5_127141_4 - EUKARYOTES_YDL134C	YDL134C	"PPH21 - Catalytic subunit of protein phosphatase 2A (PP2A), functionally redundant with Pph22p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis"	1	0.125	0	1	0.952380952	0.928571429	1	1
1232_OG5_127141_4 - EUKARYOTES_YDL188C	YDL188C	"PPH22 - Catalytic subunit of protein phosphatase 2A (PP2A), functionally redundant with Pph21p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis"	1	0.125	0	1	0.952380952	0.928571429	1	1
1233_OG5_127838_4 - EUKARYOTES_YDR390C	YDR390C	"UBA2 - Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Aos1p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability"	1	0.0625	0	1	0.952380952	0.928571429	1	1
1234_OG5_127898_4 - EUKARYOTES_YHR026W	YHR026W	"VMA16 - Subunit c'' of the vacuolar ATPase, which functions in acidification of the vacuole; one of three proteolipid subunits of the V0 domain"	1	0.0625	0	1	0.952380952	0.928571429	1	0.9375
1235_OG5_128498_4 - EUKARYOTES_YPL002C	YPL002C	"SNF8 - Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; appears to be functionally related to SNF7; involved in glucose derepression"	1	0.0625	0	1	0.952380952	0.928571429	1	0.5625
1236_OG5_127044_4 - EUKARYOTES_YPL244C	YPL244C	"HUT1 - Protein with a role in UDP-galactose transport to the Golgi lumen, has similarity to human UDP-galactose transporter UGTrel1, exhibits a genetic interaction with S. cerevisiae ERO1"	1	0	0	1	0.952380952	0.928571429	1	0.9375
1237_OG5_127203_4 - EUKARYOTES_YPR181C	YPR181C	"SEC23 - GTPase-activating protein, stimulates the GTPase activity of Sar1p; component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat, involved in ER to Golgi transport"	1	0	0	1	0.952380952	0.928571429	1	1
1238_OG5_127262_4 - EUKARYOTES_YHR010W	YHR010W	"RPL27A - Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl27Bp and has similarity to rat L27 ribosomal protein"	1	0	0	1	0.952380952	0.928571429	1	0.9375
1239_OG5_127262_4 - EUKARYOTES_YDR471W	YDR471W	"RPL27B - Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl27Ap and has similarity to rat L27 ribosomal protein"	1	0	0	1	0.952380952	0.928571429	1	0.9375
1240_OG5_127273_4 - EUKARYOTES_YGL031C	YGL031C	"RPL24A - Ribosomal protein L30 of the large (60S) ribosomal subunit, nearly identical to Rpl24Bp and has similarity to rat L24 ribosomal protein; not essential for translation but may be required for normal translation rate"	1	0	0	1	0.952380952	0.928571429	1	0.75
1241_OG5_127273_4 - EUKARYOTES_YGR148C	YGR148C	"RPL24B - Ribosomal protein L30 of the large (60S) ribosomal subunit, nearly identical to Rpl24Ap and has similarity to rat L24 ribosomal protein; not essential for translation but may be required for normal translation rate"	1	0	0	1	0.952380952	0.928571429	1	0.75
1242_OG5_127382_4 - EUKARYOTES_YAL016W	YAL016W	"TPD3 - Regulatory subunit A of the heterotrimeric protein phosphatase 2A (PP2A), which also contains regulatory subunit Cdc55p and either catalytic subunit Pph21p or Pph22p; required for cell morphogenesis and transcription by RNA polymerase III"	1	0	0	1	0.952380952	0.928571429	1	0.8125
1243_OG5_127387_4 - EUKARYOTES_YBL050W	YBL050W	"SEC17 - Peripheral membrane protein required for vesicular transport between ER and Golgi, the 'priming' step in homotypic vacuole fusion, and autophagy; stimulates the ATPase activity of Sec18p; has similarity to mammalian alpha-SNAP"	1	0	0	1	0.952380952	0.928571429	1	0.875
1244_OG5_127511_4 - EUKARYOTES_YOR033C	YOR033C	"EXO1 - 5'-3' exonuclease and flap-endonuclease involved in recombination, double-strand break repair and DNA mismatch repair; member of the Rad2p nuclease family, with conserved N and I nuclease domains"	1	0	0	1	0.952380952	0.928571429	1	0.9375
1245_OG5_127511_4 - EUKARYOTES_YDR263C	YDR263C	"DIN7 - Mitochondrial nuclease functioning in DNA repair and replication, modulates the stability of the mitochondrial genome, induced by exposure to mutagens, also induced during meiosis at a time nearly coincident with commitment to recombination"	1	0	0	1	0.952380952	0.928571429	1	0.9375
1246_OG5_127539_4 - EUKARYOTES_YAR007C	YAR007C	"RFA1 - Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination"	1	0	0	1	0.952380952	0.928571429	1	0.9375
1247_OG5_127632_4 - EUKARYOTES_YGL095C	YGL095C	"VPS45 - Protein of the Sec1p/Munc-18 family, essential for vacuolar protein sorting; required for the function of Pep12p and the early endosome/late Golgi SNARE Tlg2p; essential for fusion of Golgi-derived vesicles with the prevacuolar compartment"	1	0	0	1	0.952380952	0.928571429	1	0.875
1248_OG5_127652_4 - EUKARYOTES_YLR212C	YLR212C	"TUB4 - Gamma-tubulin, involved in nucleating microtubules from both the cytoplasmic and nuclear faces of the spindle pole body"	1	0	0	1	0.952380952	0.928571429	1	0.9375
1249_OG5_127755_4 - EUKARYOTES_YOR362C	YOR362C	PRE10 - Alpha 7 subunit of the 20S proteasome	1	0	0	1	0.952380952	0.928571429	1	0.9375
1250_OG5_127812_4 - EUKARYOTES_YOL010W	YOL010W	RCL1 - Subunit of U3-containing 90S preribosome processome complex involved in 18S rRNA biogenesis and small ribosomal subunit assembly; stimulates Bms1p GTPase and U3 binding activity; similar to RNA cyclase-like proteins but no activity detected	1	0	0	1	0.952380952	0.928571429	1	0.875
1251_OG5_127843_4 - EUKARYOTES_YLR347C	YLR347C	"KAP95 - Karyopherin beta, forms a complex with Srp1p/Kap60p; interacts with nucleoporins to mediate nuclear import of NLS-containing cargo proteins via the nuclear pore complex; regulates PC biosynthesis; GDP-to-GTP exchange factor for Gsp1p"	1	0	0	1	0.952380952	0.928571429	1	0.875
1252_OG5_127888_4 - EUKARYOTES_YPR113W	YPR113W	"PIS1 - Phosphatidylinositol synthase, required for biosynthesis of phosphatidylinositol, which is a precursor for polyphosphoinositides, sphingolipids, and glycolipid anchors for some of the plasma membrane proteins"	1	0	0	1	0.952380952	0.928571429	1	0.9375
1253_OG5_127900_4 - EUKARYOTES_YML012W	YML012W	"ERV25 - Protein that forms a heterotrimeric complex with Erp1, Erp2p, and Emp24, member of the p24 family involved in endoplasmic reticulum to Golgi transport"	1	0	0	1	0.952380952	0.928571429	1	0.75
1254_OG5_127909_4 - EUKARYOTES_YKR081C	YKR081C	RPF2 - Essential protein involved in the processing of pre-rRNA and the assembly of the 60S ribosomal subunit; interacts with ribosomal protein L11; localizes predominantly to the nucleolus; constituent of 66S pre-ribosomal particles	1	0	0	1	0.952380952	0.928571429	1	0.9375
1255_OG5_127922_4 - EUKARYOTES_YDL097C	YDL097C	"RPN6 - Essential, non-ATPase regulatory subunit of the 26S proteasome lid required for the assembly and activity of the 26S proteasome; the human homolog (S9 protein) partially rescues Rpn6p depletion"	1	0	0	1	0.952380952	0.928571429	1	0.9375
1256_OG5_127926_4 - EUKARYOTES_YLR026C	YLR026C	"SED5 - cis-Golgi t-SNARE syntaxin required for vesicular transport between the ER and the Golgi complex, binds at least 9 SNARE proteins"	1	0	0	1	0.952380952	0.928571429	1	0.8125
1257_OG5_127950_4 - EUKARYOTES_YHR027C	YHR027C	"RPN1 - Non-ATPase base subunit of the 19S regulatory particle of the 26S proteasome; may participate in the recognition of several ligands of the proteasome; contains a leucine-rich repeat (LRR) domain, a site for protein-protein interactions"	1	0	0	1	0.952380952	0.928571429	1	0.9375
1258_OG5_127978_4 - EUKARYOTES_YPL196W	YPL196W	"OXR1 - Protein of unknown function required for normal levels of resistance to oxidative damage, null mutants are sensitive to hydrogen peroxide; member of a conserved family of proteins found in eukaryotes"	1	0	0	1	0.952380952	0.928571429	1	0.375
1259_OG5_128039_4 - EUKARYOTES_YMR240C	YMR240C	"CUS1 - Protein required for assembly of U2 snRNP into the spliceosome, forms a complex with Hsh49p and Hsh155p"	1	0	0	1	0.952380952	0.928571429	1	0.875
1260_OG5_128050_4 - EUKARYOTES_YLR409C	YLR409C	UTP21 - Subunit of U3-containing 90S preribosome and Small Subunit (SSU) processome complexes involved in production of 18S rRNA and assembly of small ribosomal subunit; synthetic defect with STI1 Hsp90 cochaperone; human homolog linked to glaucoma	1	0	0	1	0.952380952	0.928571429	1	0.875
1261_OG5_128055_4 - EUKARYOTES_YGL207W	YGL207W	"SPT16 - Subunit of the heterodimeric FACT complex (Spt16p-Pob3p), which associates with chromatin via interaction with Nhp6Ap and Nhp6Bp, and reorganizes nucleosomes to facilitate access to DNA by RNA and DNA polymerases"	1	0	0	1	0.952380952	0.928571429	1	0.875
1262_OG5_128061_4 - EUKARYOTES_YER126C	YER126C	"NSA2 - Protein constituent of 66S pre-ribosomal particles, contributes to processing of the 27S pre-rRNA"	1	0	0	1	0.952380952	0.928571429	1	0.9375
1263_OG5_128129_4 - EUKARYOTES_YGR054W	YGR054W	"YGR054W - Eukaryotic initiation factor (eIF) 2A; associates specifically with both 40S subunits and 80 S ribosomes, and interacts genetically with both eIF5b and eIF4E; homologous to mammalian eIF2A"	1	0	0	1	0.952380952	0.928571429	1	0.8125
1264_OG5_128135_4 - EUKARYOTES_YER021W	YER021W	"RPN3 - Essential, non-ATPase regulatory subunit of the 26S proteasome lid, similar to the p58 subunit of the human 26S proteasome; temperature-sensitive alleles cause metaphase arrest, suggesting a role for the proteasome in cell cycle control"	1	0	0	1	0.952380952	0.928571429	1	0.8125
1265_OG5_128164_4 - EUKARYOTES_YOR272W	YOR272W	"YTM1 - Constituent of 66S pre-ribosomal particles, forms a complex with Nop7p and Erb1p that is required for maturation of the large ribosomal subunit; has seven C-terminal WD repeats"	1	0	0	1	0.952380952	0.928571429	1	0.8125
1266_OG5_128175_4 - EUKARYOTES_YIL091C	YIL091C	UTP25 - Nucleolar protein required for 35S pre-RNA processing and 40S ribosomal subunit biogenesis; contains a DEAD-box RNA helicase-like motif	1	0	0	1	0.952380952	0.928571429	1	0.875
1267_OG5_128223_4 - EUKARYOTES_YPL247C	YPL247C	YPL247C - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; similar to the petunia WD repeat protein an11; overexpression causes a cell cycle delay or arrest	1	0	0	1	0.952380952	0.928571429	1	0.4375
1268_OG5_128225_4 - EUKARYOTES_YOR294W	YOR294W	RRS1 - Essential protein that binds ribosomal protein L11 and is required for nuclear export of the 60S pre-ribosomal subunit during ribosome biogenesis; mouse homolog shows altered expression in Huntington's disease model mice	1	0	0	1	0.952380952	0.928571429	1	0.875
1269_OG5_128236_4 - EUKARYOTES_YBR247C	YBR247C	"ENP1 - Protein associated with U3 and U14 snoRNAs, required for pre-rRNA processing and 40S ribosomal subunit synthesis; localized in the nucleus and concentrated in the nucleolus"	1	0	0	1	0.952380952	0.928571429	1	0.8125
1270_OG5_128238_4 - EUKARYOTES_YJL031C	YJL031C	BET4 - Alpha subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p	1	0	0	1	0.952380952	0.928571429	1	0.8125
1271_OG5_128253_4 - EUKARYOTES_YHR088W	YHR088W	"RPF1 - Nucleolar protein involved in the assembly and export of the large ribosomal subunit; constituent of 66S pre-ribosomal particles; contains a sigma(70)-like motif, which is thought to bind RNA"	1	0	0	1	0.952380952	0.928571429	1	0.8125
1272_OG5_128256_4 - EUKARYOTES_YGL198W	YGL198W	"YIP4 - Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport"	1	0	0	1	0.952380952	0.928571429	1	0.625
1273_OG5_128309_4 - EUKARYOTES_YMR093W	YMR093W	"UTP15 - Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA"	1	0	0	1	0.952380952	0.928571429	1	0.875
1274_OG5_128644_4 - EUKARYOTES_YKL095W	YKL095W	"YJU2 - Essential protein required for pre-mRNA splicing; associates transiently with the spliceosomal NTC (""nineteen complex"") and acts after Prp2p to promote the first catalytic reaction of splicing"	1	0	0	1	0.952380952	0.928571429	1	0.625
1275_OG5_128656_4 - EUKARYOTES_YDR473C	YDR473C	"PRP3 - Splicing factor, component of the U4/U6-U5 snRNP complex"	1	0	0	1	0.952380952	0.928571429	1	0.5625
1276_OG5_128676_4 - EUKARYOTES_YDR013W	YDR013W	"PSF1 - Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery"	1	0	0	1	0.952380952	0.928571429	1	0.5
1277_OG5_128694_4 - EUKARYOTES_YDL190C	YDL190C	"UFD2 - Ubiquitin chain assembly factor (E4) that cooperates with a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), and a ubiquitin protein ligase (E3) to conjugate ubiquitin to substrates; also functions as an E3"	1	0	0	1	0.952380952	0.928571429	1	0.625
1278_OG5_129331_4 - EUKARYOTES_YLR103C	YLR103C	"CDC45 - DNA replication initiation factor; recruited to MCM pre-RC complexes at replication origins; promotes release of MCM from Mcm10p, recruits elongation machinery; mutants in human homolog may cause velocardiofacial and DiGeorge syndromes"	1	0	0	1	0.952380952	0.928571429	1	0.1875
1279_OG5_127153_4 - EUKARYOTES_YGL058W	YGL058W	"RAD6 - Ubiquitin-conjugating enzyme (E2), involved in postreplication repair (as a heterodimer with Rad18p), DSBR and checkpoint control (as a heterodimer with Bre1p), ubiquitin-mediated N-end rule protein degradation (as a heterodimer with Ubr1p"	1	0	0	1	1	0.928571429	0.95	1
1280_OG5_127732_4 - EUKARYOTES_YHR066W	YHR066W	"SSF1 - Constituent of 66S pre-ribosomal particles, required for ribosomal large subunit maturation; functionally redundant with Ssf2p; member of the Brix family"	1	0	0	1	1	0.928571429	0.95	0.875
1281_OG5_127732_4 - EUKARYOTES_YDR312W	YDR312W	"SSF2 - Protein required for ribosomal large subunit maturation, functionally redundant with Ssf1p; member of the Brix family"	1	0	0	1	1	0.928571429	0.95	0.875
1282_OG5_127890_4 - EUKARYOTES_YLL011W	YLL011W	SOF1 - Essential protein required for biogenesis of 40S (small) ribosomal subunit; has similarity to the beta subunit of trimeric G-proteins and the splicing factor Prp4p	1	0	0	1	1	0.928571429	0.95	1
1283_OG5_127701_4 - EUKARYOTES_YGR246C	YGR246C	"BRF1 - TFIIIB B-related factor, one of three subunits of RNA polymerase III transcription initiation factor TFIIIB, binds TFIIIC and TBP and recruits RNA pol III to promoters, amino-terminal half is homologous to TFIIB"	1	0.0625	0	0.875	1	1	1	0.9375
1284_OG5_127441_4 - EUKARYOTES_YBR029C	YBR029C	"CDS1 - Phosphatidate cytidylyltransferase (CDP-diglyceride synthetase); an enzyme that catalyzes that conversion of CTP + phosphate into diphosphate + CDP-diaclglyerol, a critical step in the synthesis of all major yeast phospholipids"	1	0	0.138888889	1	0.857142857	1	1	0.9375
1285_OG5_127057_4 - EUKARYOTES_YDL066W	YDL066W	"IDP1 - Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes"	1	0	0.111111111	1	0.857142857	1	1	0.625
1286_OG5_127057_4 - EUKARYOTES_YLR174W	YLR174W	"IDP2 - Cytosolic NADP-specific isocitrate dehydrogenase, catalyzes oxidation of isocitrate to alpha-ketoglutarate; levels are elevated during growth on non-fermentable carbon sources and reduced during growth on glucose"	1	0	0.111111111	1	0.857142857	1	1	0.625
1287_OG5_127057_4 - EUKARYOTES_YNL009W	YNL009W	"IDP3 - Peroxisomal NADP-dependent isocitrate dehydrogenase, catalyzes oxidation of isocitrate to alpha-ketoglutarate with the formation of NADP(H+), required for growth on unsaturated fatty acids"	1	0	0.111111111	1	0.857142857	1	1	0.625
1288_OG5_127242_4 - EUKARYOTES_YOL002C	YOL002C	"IZH2 - Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc"	1	0	0.055555556	1	0.857142857	1	1	0.3125
1289_OG5_127242_4 - EUKARYOTES_YDR492W	YDR492W	"IZH1 - Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family; transcription is regulated directly by Zap1p, expression induced by zinc deficiency and fatty acids; deletion increases sensitivity to elevated zinc"	1	0	0.055555556	1	0.857142857	1	1	0.3125
1290_OG5_127784_4 - EUKARYOTES_YHR065C	YHR065C	"RRP3 - Protein involved in rRNA processing; required for maturation of the 35S primary transcript of pre-rRNA and for cleavage leading to mature 18S rRNA; homologous to eIF-4a, which is a DEAD box RNA-dependent ATPase with helicase activity"	1	0	0.055555556	1	1	0.857142857	1	0.9375
1291_OG5_127500_4 - EUKARYOTES_YGR241C	YGR241C	"YAP1802 - Protein involved in clathrin cage assembly; binds Pan1p and clathrin; homologous to Yap1801p, member of the AP180 protein family"	1	0	0.027777778	1	0.857142857	1	1	0.25
1292_OG5_127500_4 - EUKARYOTES_YHR161C	YHR161C	"YAP1801 - Protein involved in clathrin cage assembly; binds Pan1p and clathrin; homologous to Yap1802p, member of the AP180 protein family"	1	0	0.027777778	1	0.857142857	1	1	0.25
1293_OG5_128541_4 - EUKARYOTES_YDR333C	YDR333C	YDR333C - Putative protein of unknown function	1	0	0.027777778	1	0.857142857	1	1	0.5625
1294_OG5_128575_4 - EUKARYOTES_YGL065C	YGL065C	ALG2 - Mannosyltransferase that catalyzes two consecutive steps in the N-linked glycosylation pathway; alg2 mutants exhibit temperature-sensitive growth and abnormal accumulation of the lipid-linked oligosaccharide Man2GlcNAc2-PP-Dol	1	0	0.027777778	1	0.857142857	1	1	0.5625
1295_OG5_128616_4 - EUKARYOTES_YER036C	YER036C	"ARB1 - ATPase of the ATP-binding cassette (ABC) family involved in 40S and 60S ribosome biogenesis, has similarity to Gcn20p; shuttles from nucleus to cytoplasm, physically interacts with Tif6p, Lsg1p"	1	0	0.027777778	1	0.857142857	1	1	0.3125
1296_OG5_128677_4 - EUKARYOTES_YHR075C	YHR075C	PPE1 - Protein with carboxyl methyl esterase activity that may have a role in demethylation of the phosphoprotein phosphatase catalytic subunit; also identified as a small subunit mitochondrial ribosomal protein	1	0	0.027777778	1	0.857142857	1	1	0.5
1297_OG5_127999_4 - EUKARYOTES_YPL008W	YPL008W	"CHL1 - Probable DNA helicase involved in sister-chromatid cohesion and genome integrity; interacts with ECO1 and CTF18; mutants are defective in silencing, rDNA recombination, aging and the heat shock response; FANCJ-like helicase family member"	1	0.0625	0	1	0.857142857	1	1	0.75
1298_OG5_126781_4 - EUKARYOTES_YGR040W	YGR040W	KSS1 - Mitogen-activated protein kinase (MAPK) involved in signal transduction pathways that control filamentous growth and pheromone response; the KSS1 gene is nonfunctional in S288C strains and functional in W303 strains	1	0	0	1	0.857142857	1	1	0.5625
1299_OG5_126781_4 - EUKARYOTES_YHR030C	YHR030C	"SLT2 - Serine/threonine MAP kinase; involved in regulating maintenance of cell wall integrity, progression through the cell cycle, and nuclear mRNA retention in heat shock; required for mitophagy and pexophagy; affects recruitment of mitochondria to the phagophore assembly site (PAS); regulated by the PKC1-mediated signaling pathway"	1	0	0	1	0.857142857	1	1	0.5625
1300_OG5_126781_4 - EUKARYOTES_YBL016W	YBL016W	"FUS3 - Mitogen-activated serine/threonine protein kinase involved in mating; phosphoactivated by Ste7p; substrates include Ste12p, Far1p, Bni1p, Sst2p; inhibits invasive growth during mating by phosphorylating Tec1p, promoting its degradation"	1	0	0	1	0.857142857	1	1	0.5625
1301_OG5_126805_4 - EUKARYOTES_YLR419W	YLR419W	"YLR419W - Putative helicase with limited sequence similarity to human Rb protein; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YLR419W is not an essential gene"	1	0	0	1	0.857142857	1	1	0.5
1302_OG5_126841_4 - EUKARYOTES_YBR085W	YBR085W	"AAC3 - Mitochondrial inner membrane ADP/ATP translocator, exchanges cytosolic ADP for mitochondrially synthesized ATP; expressed under anaerobic conditions; similar to Pet9p and Aac1p; has roles in maintenance of viability and in respiration"	1	0	0	1	0.857142857	1	1	0.75
1303_OG5_126841_4 - EUKARYOTES_YBL030C	YBL030C	"PET9 - Major ADP/ATP carrier of the mitochondrial inner membrane, exchanges cytosolic ADP for mitochondrially synthesized ATP; also imports heme and ATP; phosphorylated; required for viability in many lab strains that carry a sal1 mutation"	1	0	0	1	0.857142857	1	1	0.75
1304_OG5_126879_4 - EUKARYOTES_YMR079W	YMR079W	"SEC14 - Phosphatidylinositol/phosphatidylcholine transfer protein; involved in regulating PtdIns, PtdCho, and ceramide metabolism, products of which regulate intracellular transport and UPR; functionally homologous to mammalian PITPs"	1	0	0	1	0.857142857	1	1	0.5
1305_OG5_126925_4 - EUKARYOTES_YJR131W	YJR131W	"MNS1 - Alpha-1,2-mannosidase involved in ER quality control; catalyzes the removal of one mannose residue from Man9GlcNAc to produce a single isomer of Man8GlcNAc in N-linked oligosaccharide biosynthesis; integral to ER membrane"	1	0	0	1	0.857142857	1	1	0.1875
1306_OG5_127059_4 - EUKARYOTES_YIR009W	YIR009W	"MSL1 - U2B component of U2 snRNP, involved in splicing, binds the U2 snRNA stem-loop IV in vitro but requires association of Lea1p for in vivo binding; does not contain the conserved C-terminal RNA binding domain found in other family members"	1	0	0	1	0.857142857	1	1	0.8125
1307_OG5_127251_4 - EUKARYOTES_YER122C	YER122C	"GLO3 - ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Gcs1p"	1	0	0	1	0.857142857	1	1	0.9375
1308_OG5_127251_4 - EUKARYOTES_YNL204C	YNL204C	"SPS18 - Protein of unknown function, contains a putative zinc-binding domain; expressed during sporulation"	1	0	0	1	0.857142857	1	1	0.9375
1309_OG5_127278_4 - EUKARYOTES_YOL139C	YOL139C	CDC33 - Cytoplasmic mRNA cap binding protein and translation initiation factor eIF4E; the eIF4E-cap complex is responsible for mediating cap-dependent mRNA translation via interactions with translation initiation factor eIF4G (Tif4631p or Tif4632p)	1	0	0	1	0.857142857	1	1	0.75
1310_OG5_127286_4 - EUKARYOTES_YGL141W	YGL141W	"HUL5 - Multiubiquitin chain assembly factor (E4); proteasome processivity factor that elongates polyUb chains on substrates, opposing Ubp6p, a branched polyubiquitin protease; required for retrograde transport of misfolded proteins during ERAD"	1	0	0	1	0.857142857	1	1	0.6875
1311_OG5_127287_4 - EUKARYOTES_YMR165C	YMR165C	"PAH1 - Mg<sup>2+</sup>-dependent phosphatidate (PA) phosphatase, catalyzes the dephosphorylation of PA to yield diacylglycerol, responsible for de novo lipid synthesis and formation of lipid droplets; homologous to mammalian lipin 1"	1	0	0	1	0.857142857	1	1	0.875
1312_OG5_127308_4 - EUKARYOTES_YKR048C	YKR048C	NAP1 - Protein that interacts with mitotic cyclin Clb2p; required for the regulation of microtubule dynamics during mitosis; controls bud morphogenesis; involved in the transport of H2A and H2B histones to the nucleus; phosphorylated by CK2	1	0	0	1	0.857142857	1	1	0.6875
1313_OG5_127457_4 - EUKARYOTES_YIR001C	YIR001C	"SGN1 - Cytoplasmic RNA-binding protein, contains an RNA recognition motif (RRM); may have a role in mRNA translation, as suggested by genetic interactions with genes encoding proteins involved in translational initiation"	1	0	0	1	0.857142857	1	1	0.8125
1314_OG5_127494_4 - EUKARYOTES_YHR076W	YHR076W	PTC7 - Type 2C protein phosphatase (PP2C); alternatively spliced to create two mRNA isoforms; protein from spliced form localizes to the mitochondria while the one from the unspliced form is localized to the nuclear envelope	1	0	0	1	0.857142857	1	1	0.5
1315_OG5_127666_4 - EUKARYOTES_YLR025W	YLR025W	SNF7 - One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes	1	0	0	1	0.857142857	1	1	0.75
1316_OG5_127716_4 - EUKARYOTES_YOR046C	YOR046C	DBP5 - Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family involved in mRNA export from the nucleus; involved in translation termination	1	0	0	1	0.857142857	1	1	0.625
1317_OG5_127758_4 - EUKARYOTES_YMR197C	YMR197C	"VTI1 - Protein involved in cis-Golgi membrane traffic; v-SNARE that interacts with two t-SNARES, Sed5p and Pep12p; required for multiple vacuolar sorting pathways"	1	0	0	1	0.857142857	1	1	0.4375
1318_OG5_127762_4 - EUKARYOTES_YJL001W	YJL001W	"PRE3 - Beta 1 subunit of the 20S proteasome, responsible for cleavage after acidic residues in peptides"	1	0	0	1	1	0.857142857	1	1
1319_OG5_127774_4 - EUKARYOTES_YGL049C	YGL049C	"TIF4632 - Translation initiation factor eIF4G, subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); associates with the poly(A)-binding protein Pab1p, also interacts with eIF4A (Tif1p); homologous to Tif4631p"	1	0	0	1	0.857142857	1	1	0.0625
1320_OG5_127774_4 - EUKARYOTES_YGR162W	YGR162W	"TIF4631 - Translation initiation factor eIF4G, subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); interacts with Pab1p and with eIF4A (Tif1p); also has a role in biogenesis of the large ribosomal subunit"	1	0	0	1	0.857142857	1	1	0.0625
1321_OG5_127806_4 - EUKARYOTES_YFR010W	YFR010W	"UBP6 - Ubiquitin-specific protease situated in the base subcomplex of the 26S proteasome, releases free ubiquitin from branched polyubiquitin chains; works in opposition to Hul5p polyubiquitin elongation activity; mutant has aneuploidy tolerance"	1	0	0	1	0.857142857	1	1	0.8125
1322_OG5_127941_4 - EUKARYOTES_YHR024C	YHR024C	"MAS2 - Larger subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins"	1	0	0	1	0.857142857	1	1	0.8125
1323_OG5_127942_4 - EUKARYOTES_YNL262W	YNL262W	"POL2 - Catalytic subunit of DNA polymerase (II) epsilon, a chromosomal DNA replication polymerase that exhibits processivity and proofreading exonuclease activity; also involved in DNA synthesis during DNA repair; interacts extensively with Mrc1p"	1	0	0	1	0.857142857	1	1	0.9375
1324_OG5_128047_4 - EUKARYOTES_YBR142W	YBR142W	"MAK5 - Essential nucleolar protein, putative DEAD-box RNA helicase required for maintenance of M1 dsRNA virus; involved in biogenesis of large (60S) ribosomal subunits"	1	0	0	1	0.857142857	1	1	0.8125
1325_OG5_128057_4 - EUKARYOTES_YNL201C	YNL201C	"PSY2 - Subunit of protein phosphatase PP4 complex; active complex is composed of catalytic subunit Pph3p and Psy2p, with Psy4p apparently providing additional substrate specificity in some cases; regulates recovery from the DNA damage checkpoint and also the gene conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair; Pph3p and Psy2p localize to foci on meiotic chromosomes; putative homolog of mammalian R3"	1	0	0	1	0.857142857	1	1	0.4375
1326_OG5_128076_4 - EUKARYOTES_YKL189W	YKL189W	"HYM1 - Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with Kic1p and Sog2p, localizes to sites of polarized growth during budding and during the mating response"	1	0	0	1	0.857142857	1	1	0.3125
1327_OG5_128133_4 - EUKARYOTES_YEL058W	YEL058W	"PCM1 - Essential N-acetylglucosamine-phosphate mutase; converts GlcNAc-6-P to GlcNAc-1-P, which is a precursor for the biosynthesis of chitin and for the formation of N-glycosylated mannoproteins and glycosylphosphatidylinositol anchors"	1	0	0	1	0.857142857	1	1	0.875
1328_OG5_128138_4 - EUKARYOTES_YDR088C	YDR088C	"SLU7 - RNA splicing factor, required for ATP-independent portion of 2nd catalytic step of spliceosomal RNA splicing; interacts with Prp18p; contains zinc knuckle domain"	1	0	0	1	0.857142857	1	1	0.75
1329_OG5_128171_4 - EUKARYOTES_YPR082C	YPR082C	"DIB1 - 17-kDa component of the U4/U6aU5 tri-snRNP, plays an essential role in pre-mRNA splicing, orthologue of hDIM1, the human U5-specific 15-kDa protein"	1	0	0	1	0.857142857	1	1	0.9375
1330_OG5_128263_4 - EUKARYOTES_YKL139W	YKL139W	"CTK1 - Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I); phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and ribosomal protein Rps2p to increase translational fidelity; similar to the Drosophila dCDK12 and human CDK12 and probably CDK13"	1	0	0	1	0.857142857	1	1	0.3125
1331_OG5_128264_4 - EUKARYOTES_YHR171W	YHR171W	"ATG7 - Autophagy-related protein and dual specificity member of the E1 family of ubiquitin-activating enzymes; mediates the conjugation of Atg12p with Atg5p and Atg8p with phosphatidylethanolamine, required steps in autophagosome formation"	1	0	0	1	0.857142857	1	1	0.8125
1332_OG5_128272_4 - EUKARYOTES_YHR169W	YHR169W	"DBP8 - ATPase, putative RNA helicase of the DEAD-box family; component of 90S preribosome complex involved in production of 18S rRNA and assembly of 40S small ribosomal subunit; ATPase activity stimulated by association with Esf2p"	1	0	0	1	0.857142857	1	1	0.875
1333_OG5_128291_4 - EUKARYOTES_YDR468C	YDR468C	TLG1 - Essential t-SNARE that forms a complex with Tlg2p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds the docking complex VFT (Vps fifty-three) through interaction with Vps51p	1	0	0	1	0.857142857	1	1	0.625
1334_OG5_128353_4 - EUKARYOTES_YJR088C	YJR088C	EMC2 - Member of a transmembrane complex required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response	1	0	0	1	0.857142857	1	1	0.625
1335_OG5_128371_4 - EUKARYOTES_YGL080W	YGL080W	"FMP37 - Putative protein of unknown function; highly conserved across species and orthologous to human gene BRP44L; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"	1	0	0	1	0.857142857	1	1	0.625
1336_OG5_128388_4 - EUKARYOTES_YNL110C	YNL110C	"NOP15 - Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis; localizes to both nucleolus and cytoplasm"	1	0	0	1	0.857142857	1	1	0.8125
1337_OG5_128405_4 - EUKARYOTES_YNL003C	YNL003C	"PET8 - S-adenosylmethionine transporter of the mitochondrial inner membrane, member of the mitochondrial carrier family; required for biotin biosynthesis and respiratory growth"	1	0	0	1	0.857142857	1	1	0.625
1338_OG5_128407_4 - EUKARYOTES_YPL213W	YPL213W	LEA1 - Component of U2 snRNP; disruption causes reduced U2 snRNP levels; physically interacts with Msl1p; putative homolog of human U2A' snRNP protein	1	0	0	1	0.857142857	1	1	0.75
1339_OG5_128448_4 - EUKARYOTES_YDL051W	YDL051W	LHP1 - RNA binding protein required for maturation of tRNA and U6 snRNA precursors; acts as a molecular chaperone for RNAs transcribed by polymerase III; homologous to human La (SS-B) autoantigen	1	0	0	1	0.857142857	1	1	0.5625
1340_OG5_128460_4 - EUKARYOTES_YBL063W	YBL063W	"KIP1 - Kinesin-related motor protein required for mitotic spindle assembly, chromosome segregation, and 2 micron plasmid partitioning; functionally redundant with Cin8p for chromosomal but not plasmid functions"	1	0	0	1	0.857142857	1	1	0.4375
1341_OG5_128475_4 - EUKARYOTES_YKL134C	YKL134C	"YKL134C - Mitochondrial intermediate peptidase, cleaves destabilizing N-terminal residues of a subset of proteins upon import, after their cleavage by mitochondrial processing peptidase (Mas1p-Mas2p); may contribute to mitochondrial iron homeostasis"	1	0	0	1	0.857142857	1	1	0.6875
1342_OG5_128477_4 - EUKARYOTES_YLR148W	YLR148W	"PEP3 - Component of CORVET tethering complex; vacuolar peripheral membrane protein that promotes vesicular docking/fusion reactions in conjunction with SNARE proteins, required for vacuolar biogenesis"	1	0	0	1	0.857142857	1	1	0.6875
1343_OG5_128514_4 - EUKARYOTES_YBL084C	YBL084C	"CDC27 - Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition"	1	0	0	1	0.857142857	1	1	0.4375
1344_OG5_128576_4 - EUKARYOTES_YFL024C	YFL024C	"EPL1 - Component of NuA4, which is an essential histone H4/H2A acetyltransferase complex; homologous to Drosophila Enhancer of Polycomb"	1	0	0	1	0.857142857	1	1	0.125
1345_OG5_128623_4 - EUKARYOTES_YLR115W	YLR115W	"CFT2 - Subunit of the mRNA cleavage and polyadenlylation factor (CPF); required for pre-mRNA cleavage, polyadenylation and poly(A) site recognition, 43% similarity with the mammalian CPSF-100 protein."	1	0	0	1	0.857142857	1	1	0.4375
1346_OG5_128691_4 - EUKARYOTES_YGR003W	YGR003W	"CUL3 - Ubiquitin-protein ligase, forms a complex with Elc1p that polyubiquitylates monoubiquitylated RNA polymerase II to trigger its proteolysis; cullin family member with similarity to Cdc53p and human CUL3"	1	0	0	1	0.857142857	1	1	0.3125
1347_OG5_128702_4 - EUKARYOTES_YBR065C	YBR065C	"ECM2 - Pre-mRNA splicing factor, facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome, function may be regulated by Slu7p"	1	0	0	1	0.857142857	1	1	0.625
1348_OG5_128765_4 - EUKARYOTES_YDR080W	YDR080W	VPS41 - Vacuolar membrane protein that is a subunit of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex; essential for membrane docking and fusion at the Golgi-to-endosome and endosome-to-vacuole stages of protein transport	1	0	0	1	0.857142857	1	1	0.3125
1349_OG5_128776_4 - EUKARYOTES_YNL062C	YNL062C	"GCD10 - Subunit of tRNA (1-methyladenosine) methyltransferase with Gcd14p, required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression"	1	0	0	1	0.857142857	1	1	0.625
1350_OG5_128830_4 - EUKARYOTES_YJL168C	YJL168C	"SET2 - Histone methyltransferase with a role in transcriptional elongation, methylates a lysine residue of histone H3; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p"	1	0	0	1	0.857142857	1	1	0.4375
1351_OG5_128832_4 - EUKARYOTES_YHL031C	YHL031C	"GOS1 - v-SNARE protein involved in Golgi transport, homolog of the mammalian protein GOS-28/GS28"	1	0	0	1	0.857142857	1	1	0.375
1352_OG5_128937_4 - EUKARYOTES_YMR078C	YMR078C	CTF18 - Subunit of a complex with Ctf8p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion; may have overlapping functions with Rad24p in the DNA damage replication checkpoint	1	0	0	1	0.857142857	1	1	0.5625
1353_OG5_128989_4 - EUKARYOTES_YPL120W	YPL120W	VPS30 - Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II; Complex I is essential in autophagy and Complex II is required for vacuolar protein sorting; ortholog of the higher eukaryotic gene Beclin 1	1	0	0	1	0.857142857	1	1	0.3125
1354_OG5_129001_4 - EUKARYOTES_YGR005C	YGR005C	TFG2 - TFIIF (Transcription Factor II) middle subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP30	1	0	0	1	0.857142857	1	1	0.3125
1355_OG5_129145_4 - EUKARYOTES_YKL041W	YKL041W	VPS24 - One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); forms an ESCRT-III subcomplex with Did4p; involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway	1	0	0	1	0.857142857	1	1	0.3125
1356_OG5_129246_4 - EUKARYOTES_YOR004W	YOR004W	"UTP23 - Essential nucleolar protein that is a component of the SSU (small subunit) processome involved in 40S ribosomal subunit biogenesis; has homology to PINc domain protein Fcf1p, although the PINc domain of Utp23p is not required for function"	1	0	0	1	0.857142857	1	1	0.375
1357_OG5_129298_4 - EUKARYOTES_YKL125W	YKL125W	RRN3 - Protein required for transcription of rDNA by RNA polymerase I; transcription factor independent of DNA template; involved in recruitment of RNA polymerase I to rDNA	1	0	0	1	0.857142857	1	1	0.0625
1358_OG5_129338_4 - EUKARYOTES_YHR077C	YHR077C	NMD2 - Protein involved in the nonsense-mediated mRNA decay (NMD) pathway; interacts with Nam7p and Upf3p; involved in telomere maintenance	1	0	0	1	0.857142857	1	1	0.25
1359_OG5_129431_4 - EUKARYOTES_YOR123C	YOR123C	"LEO1 - Component of the Paf1 complex, which associates with RNA polymerase II and is involved in histone methylation; plays a role in regulating Ty1 transposition"	1	0	0	1	0.857142857	1	1	0.125
1360_OG5_129544_4 - EUKARYOTES_YPL101W	YPL101W	"ELP4 - Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity"	1	0	0	1	0.857142857	1	1	0.1875
1361_OG5_127303_4 - EUKARYOTES_YNL240C	YNL240C	"NAR1 - Component of the cytosolic iron-sulfur (FeS) protein assembly machinery, required for maturation of cytosolic and nuclear FeS proteins and for normal resistance to oxidative stress; homologous to human Narf"	1	0	0.138888889	1	0.904761905	1	0.95	0.8125
1362_OG5_127996_4 - EUKARYOTES_YML093W	YML093W	UTP14 - Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit	1	0	0.027777778	1	0.904761905	1	0.95	0.875
1363_OG5_128042_4 - EUKARYOTES_YMR128W	YMR128W	"ECM16 - Essential DEAH-box ATP-dependent RNA helicase specific to the U3 snoRNP, predominantly nucleolar in distribution, required for 18S rRNA synthesis"	1	0	0.027777778	1	0.904761905	1	0.95	0.9375
1364_OG5_129166_4 - EUKARYOTES_YBL020W	YBL020W	RFT1 - Essential integral membrane protein that is required for translocation of Man5GlcNac2-PP-Dol from the cytoplasmic side to the lumenal side of the ER membrane but is not the flippase; mutation is suppressed by expression of human p53 protein	1	0	0.027777778	1	0.904761905	1	0.95	0.25
1365_OG5_126740_4 - EUKARYOTES_YBR089C-A	YBR089C-A	NHP6B - High-mobility group (HMG) protein that binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to the chromosomes; functionally redundant with Nhp6Ap; homologous to mammalian HMGB1 and HMGB2	1	0	0	1	0.904761905	1	0.95	0.875
1366_OG5_126740_4 - EUKARYOTES_YPR052C	YPR052C	NHP6A - High-mobility group (HMG) protein that binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to the chromosomes; functionally redundant with Nhp6Bp; homologous to mammalian HMGB1 and HMGB2	1	0	0	1	0.904761905	1	0.95	0.875
1367_OG5_126898_4 - EUKARYOTES_YDR435C	YDR435C	"PPM1 - Carboxyl methyltransferase, methylates the C terminus of the protein phosphatase 2A catalytic subunit (Pph21p or Pph22p), which is important for complex formation with regulatory subunits"	1	0	0	1	0.904761905	1	0.95	0.8125
1368_OG5_126898_4 - EUKARYOTES_YOL141W	YOL141W	"PPM2 - AdoMet-dependent tRNA methyltransferase also involved in methoxycarbonylation; required for the synthesis of wybutosine (yW), a modified guanosine found at the 3'-position adjacent to the anticodon of phe-tRNA; similarity to Ppm1p"	1	0	0	1	0.904761905	1	0.95	0.8125
1369_OG5_126969_4 - EUKARYOTES_YBL078C	YBL078C	"ATG8 - Component of autophagosomes and Cvt vesicles; undergoes conjugation to phosphatidylethanolamine (PE); Atg8p-PE is anchored to membranes, is involved in phagophore expansion, and may mediate membrane fusion during autophagosome formation"	1	0	0	1	0.904761905	1	0.95	0.8125
1370_OG5_126971_4 - EUKARYOTES_YER031C	YER031C	"YPT31 - Rab family GTPase, very similar to Ypt32p; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi"	1	0	0	1	0.904761905	1	0.95	1
1371_OG5_126971_4 - EUKARYOTES_YGL210W	YGL210W	"YPT32 - Rab family GTPase, very similar to Ypt31p; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi"	1	0	0	1	0.904761905	1	0.95	1
1372_OG5_126981_4 - EUKARYOTES_YGL190C	YGL190C	"CDC55 - Non-essential regulatory subunit B of protein phosphatase 2A (PP2A); involved in regulation of mitotic exit; required for correct nuclear division and chromosome segregation in meiosis; maintains sequestration of the phosphatase Cdc14p in nucleolus during early meiosis, which is essential for meiosis I spindle assembly; limits formation of PP2A-Rts1p holocomplexes to ensure timely dissolution of sister chromosome cohesion; found in nucleus, bud neck and bud of most cells"	1	0	0	1	0.904761905	1	0.95	0.5625
1373_OG5_127156_4 - EUKARYOTES_YLR061W	YLR061W	"RPL22A - Protein component of the large (60S) ribosomal subunit, has similarity to Rpl22Bp and to rat L22 ribosomal protein"	1	0	0	1	0.904761905	1	0.95	0.9375
1374_OG5_127156_4 - EUKARYOTES_YFL034C-A	YFL034C-A	"RPL22B - Protein component of the large (60S) ribosomal subunit, has similarity to Rpl22Ap and to rat L22 ribosomal protein"	1	0	0	1	0.904761905	1	0.95	0.9375
1375_OG5_127495_4 - EUKARYOTES_YER039C	YER039C	"HVG1 - Protein of unknown function, has homology to Vrg4p"	1	0	0	1	0.904761905	1	0.95	0.375
1376_OG5_127495_4 - EUKARYOTES_YGL225W	YGL225W	VRG4 - Golgi GDP-mannose transporter; regulates Golgi function and glycosylation in Golgi	1	0	0	1	0.904761905	1	0.95	0.375
1377_OG5_127498_4 - EUKARYOTES_YDR424C	YDR424C	"DYN2 - Cytoplasmic light chain dynein, microtubule motor protein; proposed to be involved in the assembly of the nuclear pore complex"	1	0	0	1	0.904761905	1	0.95	0.875
1378_OG5_127537_4 - EUKARYOTES_YMR308C	YMR308C	"PSE1 - Karyopherin/importin that interacts with the nuclear pore complex; acts as the nuclear import receptor for specific proteins, including Pdr1p, Yap1p, Ste12p, and Aft1p"	1	0	0	1	0.904761905	1	0.95	0.8125
1379_OG5_127629_4 - EUKARYOTES_YBR261C	YBR261C	TAE1 - AdoMet-dependent proline methyltransferase; catalyzes the dimethylation of ribosomal proteins Rpl12 and Rps25 at N-terminal proline residues; has a role in protein synthesis; fusion protein localizes to the cytoplasm	1	0	0	1	0.904761905	1	0.95	0.625
1380_OG5_127747_4 - EUKARYOTES_YML130C	YML130C	ERO1 - Thiol oxidase required for oxidative protein folding in the endoplasmic reticulum	1	0	0	1	0.904761905	1	0.95	0.8125
1381_OG5_127799_4 - EUKARYOTES_YLR005W	YLR005W	"SSL1 - Component of the core form of RNA polymerase transcription factor TFIIH, which has both protein kinase and DNA-dependent ATPase/helicase activities and is essential for transcription and nucleotide excision repair; interacts with Tfb4p"	1	0	0	1	0.904761905	1	0.95	0.9375
1382_OG5_127870_4 - EUKARYOTES_YMR073C	YMR073C	IRC21 - Putative protein of unknown function; may be involved in resistance to carboplatin and cisplatin; null mutant displays increase in spontaneous Rad52p foci; contains a lipid-binding domain and binds cardiolipin in a large-scale study	1	0	0	1	0.904761905	1	0.95	0.6875
1383_OG5_127886_4 - EUKARYOTES_YJL154C	YJL154C	"VPS35 - Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval"	1	0	0	1	0.904761905	1	0.95	0.8125
1384_OG5_128025_4 - EUKARYOTES_YGL161C	YGL161C	"YIP5 - Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport"	1	0	0	1	0.904761905	1	0.95	0.5
1385_OG5_128198_4 - EUKARYOTES_YOL027C	YOL027C	"MDM38 - Mitochondrial protein, forms a complex with Mba1p to facilitate recruitment of mRNA-specific translational activators to ribosomes; roles in protein export and K+/H+ exchange; human ortholog Letm1 implicated in Wolf-Hirschhorn syndrome"	1	0	0	1	0.904761905	1	0.95	0.625
1386_OG5_128198_4 - EUKARYOTES_YPR125W	YPR125W	"YLH47 - Mitochondrial inner membrane protein exposed to the mitochondrial matrix, associates with mitochondrial ribosomes, NOT required for respiratory growth; homolog of human Letm1, a protein implicated in Wolf-Hirschhorn syndrome"	1	0	0	1	0.904761905	1	0.95	0.625
1387_OG5_128322_4 - EUKARYOTES_YDR364C	YDR364C	"CDC40 - Pre-mRNA splicing factor, important for catalytic step II of pre-mRNA splicing and plays a role in cell cycle progression; required for DNA synthesis during mitosis and meiosis; has WD repeats"	1	0	0	1	0.904761905	1	0.95	0.8125
1388_OG5_128652_4 - EUKARYOTES_YPR178W	YPR178W	"PRP4 - Splicing factor, component of the U4/U6-U5 snRNP complex"	1	0	0	1	0.904761905	1	0.95	0.625
1389_OG5_128741_4 - EUKARYOTES_YBR079C	YBR079C	"RPG1 - eIF3a subunit of the core complex of translation initiation factor 3 (eIF3), essential for translation; part of a Prt1p-Rpg1p-Nip1p subcomplex that stimulates binding of mRNA and tRNA(i)Met to ribosomes; involved in translation reinitiation"	1	0	0	1	0.904761905	1	0.95	0.625
1390_OG5_129291_4 - EUKARYOTES_YER157W	YER157W	"COG3 - Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments"	1	0	0	1	0.952380952	1	0.9	0.3125
1391_OG5_127772_4 - EUKARYOTES_YGR231C	YGR231C	"PHB2 - Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation"	1	0.125	0.111111111	1	0.904761905	0.928571429	1	0.75
1392_OG5_128258_4 - EUKARYOTES_YPL132W	YPL132W	COX11 - Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p	1	0	0.194444444	1	0.904761905	0.928571429	1	0.625
1393_OG5_128093_4 - EUKARYOTES_YLL008W	YLL008W	"DRS1 - Nucleolar DEAD-box protein required for ribosome assembly and function, including synthesis of 60S ribosomal subunits; constituent of 66S pre-ribosomal particles"	1	0	0.166666667	1	0.904761905	0.928571429	1	0.8125
1394_OG5_127223_4 - EUKARYOTES_YCR072C	YCR072C	"RSA4 - WD-repeat protein involved in ribosome biogenesis; may interact with ribosomes; required for maturation and efficient intra-nuclear transport or pre-60S ribosomal subunits, localizes to the nucleolus"	1	0	0.055555556	1	0.904761905	0.928571429	1	0.9375
1395_OG5_126703_4 - EUKARYOTES_YLL039C	YLL039C	"UBI4 - Ubiquitin, becomes conjugated to proteins, marking them for selective degradation via the ubiquitin-26S proteasome system; essential for the cellular stress response; encoded as a polyubiquitin precursor comprised of 5 head-to-tail repeats"	1	0	0.027777778	1	0.904761905	0.928571429	1	1
1396_OG5_126707_4 - EUKARYOTES_YGL255W	YGL255W	"ZRT1 - High-affinity zinc transporter of the plasma membrane, responsible for the majority of zinc uptake; transcription is induced under low-zinc conditions by the Zap1p transcription factor"	1	0	0.027777778	1	0.904761905	0.928571429	1	0.8125
1397_OG5_126707_4 - EUKARYOTES_YLR130C	YLR130C	ZRT2 - Low-affinity zinc transporter of the plasma membrane; transcription is induced under low-zinc conditions by the Zap1p transcription factor	1	0	0.027777778	1	0.904761905	0.928571429	1	0.8125
1398_OG5_127098_4 - EUKARYOTES_YGL163C	YGL163C	"RAD54 - DNA-dependent ATPase, stimulates strand exchange by modifying the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; member of the SWI/SNF family"	1	0	0.027777778	1	0.904761905	0.928571429	1	0.75
1399_OG5_127098_4 - EUKARYOTES_YBR073W	YBR073W	"RDH54 - DNA-dependent ATPase, stimulates strand exchange by modifying the topology of double-stranded DNA; involved in recombinational repair of DNA double-strand breaks during mitosis and meiosis; proposed to be involved in crossover interference"	1	0	0.027777778	1	0.904761905	0.928571429	1	0.75
1400_OG5_128432_4 - EUKARYOTES_YIL083C	YIL083C	"CAB2 - Probable phosphopantothenoylcysteine synthetase (PPCS), which catalyzes the second step of coenzyme A biosynthesis from pantothenate; null mutant lethality is complemented by E. coli coaBC (encoding a bifunctional enzyme with PPCS activity)"	1	0	0.027777778	1	0.904761905	0.928571429	1	0.5
1401_OG5_127791_4 - EUKARYOTES_YML092C	YML092C	PRE8 - Alpha 2 subunit of the 20S proteasome	1	0.1875	0	1	0.904761905	0.928571429	1	0.9375
1402_OG5_127717_4 - EUKARYOTES_YJR099W	YJR099W	YUH1 - Ubiquitin C-terminal hydrolase that cleaves ubiquitin-protein fusions to generate monomeric ubiquitin; hydrolyzes the peptide bond at the C-terminus of ubiquitin; also the major processing enzyme for the ubiquitin-like protein Rub1p	1	0.0625	0	1	0.904761905	0.928571429	1	0.6875
1403_OG5_127904_4 - EUKARYOTES_YGR020C	YGR020C	"VMA7 - Subunit F of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane"	1	0.0625	0	1	0.904761905	0.928571429	1	1
1404_OG5_127104_4 - EUKARYOTES_YKR002W	YKR002W	"PAP1 - Poly(A) polymerase, one of three factors required for mRNA 3'-end polyadenylation, forms multiprotein complex with polyadenylation factor I (PF I), also required for mRNA nuclear export; may also polyadenylate rRNAs"	1	0	0	1	0.904761905	0.928571429	1	1
1405_OG5_127142_4 - EUKARYOTES_YPL170W	YPL170W	"DAP1 - Heme-binding protein involved in regulation of cytochrome P450 protein Erg11p; damage response protein, related to mammalian membrane progesterone receptors; mutations lead to defects in telomeres, mitochondria, and sterol synthesis"	1	0	0	1	0.904761905	0.928571429	1	0.4375
1406_OG5_127212_4 - EUKARYOTES_YJR066W	YJR066W	"TOR1 - PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis"	1	0	0	1	0.904761905	0.928571429	1	0.5625
1407_OG5_127212_4 - EUKARYOTES_YKL203C	YKL203C	"TOR2 - PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis"	1	0	0	1	0.904761905	0.928571429	1	0.5625
1408_OG5_127432_4 - EUKARYOTES_YKR035W-A	YKR035W-A	DID2 - Class E protein of the vacuolar protein-sorting (Vps) pathway; binds Vps4p and directs it to dissociate ESCRT-III complexes; forms a functional and physical complex with Ist1p; human ortholog may be altered in breast tumors	1	0	0	1	0.904761905	0.928571429	1	0.8125
1409_OG5_127633_4 - EUKARYOTES_YER174C	YER174C	GRX4 - Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx3p and Grx5p; protects cells from oxidative damage; mutant has increased aneuploidy tolerance	1	0	0	1	0.904761905	0.928571429	1	0.875
1410_OG5_127633_4 - EUKARYOTES_YDR098C	YDR098C	GRX3 - Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx4p and Grx5p; protects cells from oxidative damage	1	0	0	1	0.904761905	0.928571429	1	0.875
1411_OG5_128010_4 - EUKARYOTES_YIL007C	YIL007C	NAS2 - Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); similar to mammalian proteasomal modulator subunit; non-essential gene; interacts with Rpn4p	1	0	0	1	0.904761905	0.928571429	1	0.875
1412_OG5_128022_4 - EUKARYOTES_YDL043C	YDL043C	"PRP11 - Subunit of the SF3a splicing factor complex, required for spliceosome assembly"	1	0	0	1	0.904761905	0.928571429	1	0.9375
1413_OG5_128053_4 - EUKARYOTES_YDR331W	YDR331W	GPI8 - ER membrane glycoprotein subunit of the glycosylphosphatidylinositol transamidase complex that adds glycosylphosphatidylinositol (GPI) anchors to newly synthesized proteins; human PIG-K protein is a functional homolog	1	0	0	1	0.904761905	0.928571429	1	0.875
1414_OG5_128148_4 - EUKARYOTES_YDR365C	YDR365C	ESF1 - Nucleolar protein involved in pre-rRNA processing; depletion causes severely decreased 18S rRNA levels	1	0	0	1	0.904761905	0.928571429	1	0.875
1415_OG5_128177_4 - EUKARYOTES_YNL102W	YNL102W	"POL1 - Catalytic subunit of the DNA polymerase I alpha-primase complex, required for the initiation of DNA replication during mitotic DNA synthesis and premeiotic DNA synthesis"	1	0	0	1	0.904761905	0.928571429	1	0.9375
1416_OG5_128207_4 - EUKARYOTES_YGR078C	YGR078C	"PAC10 - Part of the heteromeric co-chaperone GimC/prefoldin complex, which promotes efficient protein folding"	1	0	0	1	0.904761905	0.928571429	1	0.875
1417_OG5_128219_4 - EUKARYOTES_YJR125C	YJR125C	ENT3 - Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p	1	0	0	1	0.904761905	0.928571429	1	0.6875
1418_OG5_128380_4 - EUKARYOTES_YHR186C	YHR186C	"KOG1 - Subunit of TORC1, a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p, Lst8p and Tco89p; contains four HEAT repeats and seven WD-40 repeats; may act as a scaffold protein to couple TOR and its effectors"	1	0	0	1	0.904761905	0.928571429	1	0.375
1419_OG5_128381_4 - EUKARYOTES_YBR254C	YBR254C	TRS20 - One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; mutations in the human homolog cause the spondyloepiphyseal dysplasia tarda (SEDL) disorder	1	0	0	1	0.904761905	0.928571429	1	0.75
1420_OG5_128386_4 - EUKARYOTES_YBR136W	YBR136W	MEC1 - Genome integrity checkpoint protein and PI kinase superfamily member; signal transducer required for cell cycle arrest and transcriptional responses prompted by damaged or unreplicated DNA; monitors and participates in meiotic recombination	1	0	0	1	0.904761905	0.928571429	1	0.6875
1421_OG5_128440_4 - EUKARYOTES_YLR323C	YLR323C	"CWC24 - Essential protein, component of a complex containing Cef1p; has similarity to S. pombe Cwf24p"	1	0	0	1	0.904761905	0.928571429	1	0.6875
1422_OG5_128513_4 - EUKARYOTES_YNL153C	YNL153C	GIM3 - Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it	1	0	0	1	0.904761905	0.928571429	1	0.8125
1423_OG5_128599_4 - EUKARYOTES_YPR133C	YPR133C	"SPN1 - Protein involved in RNA polymerase II transcription; interacts genetically or physically with RNAP II, TBP, TFIIS, and chromatin remodelling factors; central domain highly conserved throughout eukaryotes; mutations confer an Spt- phenotype"	1	0	0	1	0.904761905	0.928571429	1	0.6875
1424_OG5_128631_4 - EUKARYOTES_YNL022C	YNL022C	"YNL022C - Putative cytosine 5-methyltransferase, contains seven beta-strand methyltransferase motif similar to NOP2/YNL061W; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; predicted to be involved in ribosome biogenesis"	1	0	0	1	0.904761905	0.928571429	1	0.5625
1425_OG5_128657_4 - EUKARYOTES_YDR221W	YDR221W	"GTB1 - Glucosidase II beta subunit, forms a complex with alpha subunit Rot2p, involved in removal of two glucose residues from N-linked glycans during glycoprotein biogenesis in the ER"	1	0	0	1	0.904761905	0.928571429	1	0.375
1426_OG5_128675_4 - EUKARYOTES_YGR258C	YGR258C	"RAD2 - Single-stranded DNA endonuclease, cleaves single-stranded DNA during nucleotide excision repair to excise damaged DNA; subunit of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPG protein"	1	0	0	1	0.904761905	0.928571429	1	0.625
1427_OG5_128768_4 - EUKARYOTES_YFR005C	YFR005C	"SAD1 - Conserved zinc-finger domain protein involved in pre-mRNA splicing, required for assembly of U4 snRNA into the U4/U6 particle"	1	0	0	1	0.904761905	0.928571429	1	0.625
1428_OG5_128785_4 - EUKARYOTES_YDR490C	YDR490C	"PKH1 - Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh2p"	1	0	0	1	0.904761905	0.928571429	1	0.1875
1429_OG5_128785_4 - EUKARYOTES_YOL100W	YOL100W	"PKH2 - Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh1p"	1	0	0	1	0.904761905	0.928571429	1	0.1875
1430_OG5_128793_4 - EUKARYOTES_YBL035C	YBL035C	"POL12 - B subunit of DNA polymerase alpha-primase complex, required for initiation of DNA replication during mitotic and premeiotic DNA synthesis; also functions in telomere capping and length regulation"	1	0	0	1	0.904761905	0.928571429	1	0.625
1431_OG5_128888_4 - EUKARYOTES_YDR489W	YDR489W	"SLD5 - Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery"	1	0	0	1	0.904761905	0.928571429	1	0.375
1432_OG5_128890_4 - EUKARYOTES_YHR052W	YHR052W	CIC1 - Essential protein that interacts with proteasome components and has a potential role in proteasome substrate specificity; also copurifies with 66S pre-ribosomal particles	1	0	0	1	0.904761905	0.928571429	1	0.5
1433_OG5_129082_4 - EUKARYOTES_YJL069C	YJL069C	"UTP18 - Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data"	1	0	0	1	0.904761905	0.928571429	1	0.5625
1434_OG5_129148_4 - EUKARYOTES_YMR235C	YMR235C	"RNA1 - GTPase activating protein (GAP) for Gsp1p, involved in nuclear transport"	1	0	0	1	0.904761905	0.928571429	1	0.25
1435_OG5_128600_4 - EUKARYOTES_YOR253W	YOR253W	"NAT5 - Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing"	1	0.125	0.055555556	1	0.952380952	0.928571429	0.95	0.4375
1436_OG5_127013_4 - EUKARYOTES_YDR411C	YDR411C	"DFM1 - Endoplasmic reticulum (ER) localized protein involved in ER-associated protein degradation (ERAD), ER stress and homeostasis; interacts with components of ERAD-L and ERAD-C and Cdc48p; derlin-like family member similar to Der1p"	1	0	0	1	0.952380952	0.928571429	0.95	1
1437_OG5_127013_4 - EUKARYOTES_YBR201W	YBR201W	"DER1 - Endoplasmic reticulum membrane protein, required for ER-associated protein degradation of misfolded or unassembled proteins; N- and C- termini protrude into the cytoplasm, has similarity to Dfm1p"	1	0	0	1	0.952380952	0.928571429	0.95	1
1438_OG5_127730_4 - EUKARYOTES_YIL142W	YIL142W	"CCT2 - Subunit beta of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo"	1	0	0	1	0.952380952	0.928571429	0.95	0.9375
1439_OG5_128106_4 - EUKARYOTES_YCR057C	YCR057C	"PWP2 - Conserved 90S pre-ribosomal component essential for proper endonucleolytic cleavage of the 35 S rRNA precursor at A0, A1, and A2 sites; contains eight WD-repeats; PWP2 deletion leads to defects in cell cycle and bud morphogenesis"	1	0	0	1	0.952380952	0.928571429	0.95	0.875
1440_OG5_128298_4 - EUKARYOTES_YDL031W	YDL031W	"DBP10 - Putative ATP-dependent RNA helicase of the DEAD-box protein family, constituent of 66S pre-ribosomal particles; essential protein involved in ribosome biogenesis"	1	0	0	1	0.952380952	0.928571429	0.95	0.8125
1441_OG5_128303_4 - EUKARYOTES_YEL003W	YEL003W	GIM4 - Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it	1	0	0	1	0.952380952	0.928571429	0.95	0.75
1442_OG5_128318_4 - EUKARYOTES_YGL240W	YGL240W	"DOC1 - Processivity factor required for the ubiquitination activity of the anaphase promoting complex (APC), mediates the activity of the APC by contributing to substrate recognition; involved in cyclin proteolysis; contains a conserved DOC1 homology domain"	1	0	0	1	0.952380952	0.928571429	0.95	0.75
1443_OG5_128343_4 - EUKARYOTES_YNL147W	YNL147W	"LSM7 - Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA"	1	0	0	1	0.952380952	0.928571429	0.95	0.6875
1444_OG5_128536_4 - EUKARYOTES_YMR132C	YMR132C	"JLP2 - Protein of unknown function, contains sequence that closely resembles a J domain (typified by the E. coli DnaJ protein)"	1	0	0	1	0.952380952	0.928571429	0.95	0.5625
1445_OG5_129075_4 - EUKARYOTES_YNL006W	YNL006W	LST8 - Protein required for the transport of amino acid permease Gap1p from the Golgi to the cell surface; component of the TOR signaling pathway; associates with both Tor1p and Tor2p; contains a WD-repeat	1	0	0	1	0.952380952	0.928571429	0.95	0.25
1446_OG5_127986_4 - EUKARYOTES_YOL133W	YOL133W	"HRT1 - RING finger containing subunit of Skp1-Cullin-F-box ubiquitin protein ligases (SCF); required for Gic2p, Far1p, Sic1p and Cln2p degradation; may tether Cdc34p (a ubiquitin conjugating enzyme or E2) and Cdc53p (a cullin) subunits of SCF"	1	0	0	1	1	0.928571429	0.9	0.8125
1447_OG5_127190_4 - EUKARYOTES_YIL044C	YIL044C	"AGE2 - ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in Trans-Golgi-Network (TGN) transport; contains C2C2H2 cysteine/histidine motif"	1	0	0.027777778	0.875	0.952380952	1	1	0.875
1448_OG5_127406_4 - EUKARYOTES_YNL271C	YNL271C	"BNI1 - Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNR1"	1	0	0.027777778	0.875	0.952380952	1	1	0.125
1449_OG5_128519_4 - EUKARYOTES_YNL172W	YNL172W	"APC1 - Largest subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis"	1	0	0.027777778	0.875	0.952380952	1	1	0.3125
1450_OG5_128137_4 - EUKARYOTES_YGR083C	YGR083C	"GCD2 - Delta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression"	1	0.0625	0	0.875	0.952380952	1	1	0.6875
1451_OG5_126706_4 - EUKARYOTES_YER177W	YER177W	"BMH1 - 14-3-3 protein, major isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling"	1	0	0	0.875	0.952380952	1	1	1
1452_OG5_126706_4 - EUKARYOTES_YDR099W	YDR099W	"BMH2 - 14-3-3 protein, minor isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling"	1	0	0	0.875	0.952380952	1	1	1
1453_OG5_126754_4 - EUKARYOTES_YMR243C	YMR243C	"ZRC1 - Vacuolar membrane zinc transporter, transports zinc from the cytosol into the vacuole for storage; also has a role in resistance to zinc shock resulting from a sudden influx of zinc into the cytoplasm"	1	0	0	0.875	0.952380952	1	1	0.625
1454_OG5_126754_4 - EUKARYOTES_YOR316C	YOR316C	COT1 - Vacuolar transporter that mediates zinc transport into the vacuole; overexpression confers resistance to cobalt and rhodium	1	0	0	0.875	0.952380952	1	1	0.625
1455_OG5_126869_4 - EUKARYOTES_YLL013C	YLL013C	"PUF3 - Protein of the mitochondrial outer surface, links the Arp2/3 complex with the mitochore during anterograde mitochondrial movement; also binds to and promotes degradation of mRNAs for select nuclear-encoded mitochondrial proteins"	1	0	0	0.875	0.952380952	1	1	0.6875
1456_OG5_127063_4 - EUKARYOTES_YIL106W	YIL106W	MOB1 - Component of the mitotic exit network; associates with and is required for the activation and Cdc15p-dependent phosphorylation of the Dbf2p kinase; required for cytokinesis and cell separation; component of the CCR4 transcriptional complex	1	0	0	0.875	0.952380952	1	1	0.625
1457_OG5_127213_4 - EUKARYOTES_YIL153W	YIL153W	"RRD1 - Peptidyl-prolyl cis/trans-isomerase; activator of the phosphotyrosyl phosphatase activity of PP2A; involved in G1 phase progression, microtubule dynamics, bud morphogenesis and DNA repair; required for rapid reduction of Sgs1p levels in response to rapamycin; subunit of the Tap42p-Sit4p-Rrd1p complex"	1	0	0	0.875	0.952380952	1	1	0.9375
1458_OG5_127213_4 - EUKARYOTES_YPL152W	YPL152W	"RRD2 - Activator of the phosphotyrosyl phosphatase activity of PP2A,peptidyl-prolyl cis/trans-isomerase; regulates G1 phase progression, the osmoresponse, microtubule dynamics; subunit of the Tap42p-Pph21p-Rrd2p complex"	1	0	0	0.875	0.952380952	1	1	0.9375
1459_OG5_127454_4 - EUKARYOTES_YOL093W	YOL093W	"TRM10 - tRNA methyltransferase, methylates the N-1 position of guanosine in tRNAs"	1	0	0	0.875	0.952380952	1	1	0.8125
1460_OG5_127612_4 - EUKARYOTES_YBL058W	YBL058W	SHP1 - UBX (ubiquitin regulatory X) domain-containing protein that regulates Glc7p phosphatase activity and interacts with Cdc48p; interacts with ubiquitylated proteins in vivo and is required for degradation of a ubiquitylated model substrate	1	0	0	0.875	0.952380952	1	1	0.75
1461_OG5_127615_4 - EUKARYOTES_YBR267W	YBR267W	"REI1 - Cytoplasmic pre-60S factor; required for the correct recycling of shuttling factors Alb1, Arx1 and Tif6 at the end of the ribosomal large subunit biogenesis; involved in bud growth in the mitotic signaling network"	1	0	0	0.875	0.952380952	1	1	0.875
1462_OG5_127615_4 - EUKARYOTES_YLR387C	YLR387C	"REH1 - Cytoplasmic 60S subunit biogenesis factor, associates with pre-60S particles; similar to Rei1p and shares partially redundant function in cytoplasmic 60S subunit maturation; contains dispersed C2H2 zinc finger domains"	1	0	0	0.875	0.952380952	1	1	0.875
1463_OG5_127685_4 - EUKARYOTES_YOR070C	YOR070C	"GYP1 - Cis-golgi GTPase-activating protein (GAP) for the Rab family members Ypt1p (in vivo) and for Ypt1p, Sec4p, Ypt7p, and Ypt51p (in vitro); involved in vesicle docking and fusion"	1	0	0	0.875	0.952380952	1	1	0.8125
1464_OG5_128060_4 - EUKARYOTES_YJL029C	YJL029C	"VPS53 - Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; required for vacuolar protein sorting"	1	0	0	0.875	0.952380952	1	1	0.75
1465_OG5_128278_4 - EUKARYOTES_YNL163C	YNL163C	RIA1 - Cytoplasmic GTPase involved in biogenesis of the 60S ribosome; has similarity to translation elongation factor 2 (Eft1p and Eft2p)	1	0	0	0.875	0.952380952	1	1	0.8125
1466_OG5_128493_4 - EUKARYOTES_YPL243W	YPL243W	SRP68 - Core component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane	1	0	0	0.875	0.952380952	1	1	0.5625
1467_OG5_128494_4 - EUKARYOTES_YMR077C	YMR077C	"VPS20 - Myristoylated subunit of ESCRTIII, the endosomal sorting complex required for transport of transmembrane proteins into the multivesicular body pathway to the lysosomal/vacuolar lumen; cytoplasmic protein recruited to endosomal membranes"	1	0	0	0.875	0.952380952	1	1	0.5
1468_OG5_128004_4 - EUKARYOTES_YAL025C	YAL025C	"MAK16 - Essential nuclear protein, constituent of 66S pre-ribosomal particles; required for maturation of 25S and 5.8S rRNAs; required for maintenance of M1 satellite double-stranded RNA of the L-A virus"	1	0	0	0.875	1	1	0.95	0.9375
1469_OG5_127749_4 - EUKARYOTES_YML080W	YML080W	"DUS1 - Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus3p, and Dus4p; modifies pre-tRNA(Phe) at U17"	1	0.0625	0.027777778	1	0.952380952	0.857142857	1	1
1470_OG5_128784_4 - EUKARYOTES_YDL178W	YDL178W	"DLD2 - D-lactate dehydrogenase, located in the mitochondrial matrix"	1	0	0.194444444	1	0.80952381	1	1	0.1875
1471_OG5_128784_4 - EUKARYOTES_YEL071W	YEL071W	"DLD3 - D-lactate dehydrogenase, part of the retrograde regulon which consists of genes whose expression is stimulated by damage to mitochondria and reduced in cells grown with glutamate as the sole nitrogen source, located in the cytoplasm"	1	0	0.194444444	1	0.80952381	1	1	0.1875
1472_OG5_127677_4 - EUKARYOTES_YER156C	YER156C	"YER156C - Putative protein of unknown function; interacts with Hsp82p and copurifies with Ipl1p; expression is copper responsive and downregulated in strains deleted for MAC1, a copper-responsive transcription factor; similarity to mammalian MYG1"	1	0	0.055555556	1	0.952380952	0.857142857	1	0.875
1473_OG5_128571_4 - EUKARYOTES_YIL022W	YIL022W	TIM44 - Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); tethers the import motor and regulatory factors (PAM complex) to the translocation channel (Tim23p-Tim17p core complex)	1	0	0.055555556	1	0.80952381	1	1	0.625
1474_OG5_128077_4 - EUKARYOTES_YMR281W	YMR281W	"GPI12 - ER membrane protein involved in the second step of glycosylphosphatidylinositol (GPI) anchor assembly, the de-N-acetylation of the N-acetylglucosaminylphosphatidylinositol intermediate; functional homolog of human PIG-Lp"	1	0	0.027777778	1	0.80952381	1	1	0.8125
1475_OG5_129286_4 - EUKARYOTES_YAL019W	YAL019W	"FUN30 - Conserved member of the Snf2p family with ATP-dependent chromatin remodeling activity; has a role in silencing; potential Cdc28p substrate; authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies"	1	0	0.027777778	1	0.80952381	1	1	0.125
1476_OG5_127855_4 - EUKARYOTES_YCL059C	YCL059C	KRR1 - Essential nucleolar protein required for the synthesis of 18S rRNA and for the assembly of 40S ribosomal subunit	1	0.125	0	1	0.952380952	0.857142857	1	1
1477_OG5_129426_4 - EUKARYOTES_YLR166C	YLR166C	"SEC10 - Essential 100kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosis"	1	0.0625	0	1	0.80952381	1	1	0.125
1478_OG5_126663_4 - EUKARYOTES_YBR139W	YBR139W	"YBR139W - Putative serine type carboxypeptidase with a role in phytochelatin synthesis; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner"	1	0	0	1	0.80952381	1	1	0.3125
1479_OG5_126663_4 - EUKARYOTES_YMR297W	YMR297W	"PRC1 - Vacuolar carboxypeptidase Y (proteinase C; CPY), broad-specificity C-terminal exopeptidase involved in non-specific protein degradation in the vacuole; member of the serine carboxypeptidase family"	1	0	0	1	0.80952381	1	1	0.3125
1480_OG5_126724_4 - EUKARYOTES_YOR089C	YOR089C	VPS21 - Rab family GTPase required for endocytic transport and for sorting of vacuolar hydrolases; localized in endocytic intermediates; detected in mitochondria; geranylgeranylation required for membrane association; mammalian Rab5 homolog	1	0	0	1	0.80952381	1	1	0.9375
1481_OG5_126724_4 - EUKARYOTES_YKR014C	YKR014C	"YPT52 - Rab family GTPase, similar to Ypt51p and Ypt53p and to mammalian rab5; required for vacuolar protein sorting and endocytosis"	1	0	0	1	0.80952381	1	1	0.9375
1482_OG5_127069_4 - EUKARYOTES_YNR023W	YNR023W	SNF12 - 73 kDa subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; homolog of Rsc6p subunit of the RSC chromatin remodeling complex; deletion mutants are temperature-sensitive	1	0	0	1	0.80952381	1	1	0.375
1483_OG5_127069_4 - EUKARYOTES_YCR052W	YCR052W	RSC6 - Component of the RSC chromatin remodeling complex; essential for mitotic growth; homolog of SWI/SNF subunit Swp73p	1	0	0	1	0.80952381	1	1	0.375
1484_OG5_127304_4 - EUKARYOTES_YJL128C	YJL128C	PBS2 - MAP kinase kinase of the HOG signaling pathway; activated under severe osmotic stress; mitophagy-specific regulator; plays a role in regulating Ty1 transposition	1	0	0	1	0.80952381	1	1	0.5
1485_OG5_127304_4 - EUKARYOTES_YDL159W	YDL159W	"STE7 - Signal transducing MAP kinase kinase involved in pheromone response, where it phosphorylates Fus3p, and in the pseudohyphal/invasive growth pathway, through phosphorylation of Kss1p; phosphorylated by Ste11p, degraded by ubiquitin pathway"	1	0	0	1	0.80952381	1	1	0.5
1486_OG5_127609_4 - EUKARYOTES_YDR084C	YDR084C	TVP23 - Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern	1	0	0	1	0.80952381	1	1	0.6875
1487_OG5_127654_4 - EUKARYOTES_YPL010W	YPL010W	"RET3 - Zeta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER"	1	0	0	1	0.952380952	0.857142857	1	0.6875
1488_OG5_127689_4 - EUKARYOTES_YPR072W	YPR072W	"NOT5 - Subunit of the CCR4-NOT complex, which is a global transcriptional regulator with roles in transcription initiation and elongation and in mRNA degradation"	1	0	0	1	0.952380952	0.857142857	1	0.875
1489_OG5_127689_4 - EUKARYOTES_YIL038C	YIL038C	"NOT3 - Subunit of the CCR4-NOT complex, which is a global transcriptional regulator with roles in transcription initiation and elongation and in mRNA degradation"	1	0	0	1	0.952380952	0.857142857	1	0.875
1490_OG5_127723_4 - EUKARYOTES_YKL190W	YKL190W	"CNB1 - Calcineurin B; the regulatory subunit of calcineurin, a Ca++/calmodulin-regulated type 2B protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is encoded by CNA1 and/or CMP1"	1	0	0	1	0.952380952	0.857142857	1	0.6875
1491_OG5_127733_4 - EUKARYOTES_YLR275W	YLR275W	"SMD2 - Core Sm protein Sm D2; part of heteroheptameric complex (with Smb1p, Smd1p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D2"	1	0	0	1	0.952380952	0.857142857	1	0.9375
1492_OG5_127796_4 - EUKARYOTES_YER082C	YER082C	"UTP7 - Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA"	1	0	0	1	0.952380952	0.857142857	1	0.9375
1493_OG5_127846_4 - EUKARYOTES_YOL004W	YOL004W	"SIN3 - Component of the Sin3p-Rpd3p histone deacetylase complex, involved in transcriptional repression and activation of diverse processes, including mating-type switching and meiosis; involved in the maintenance of chromosomal integrity"	1	0	0	1	0.80952381	1	1	0.3125
1494_OG5_127869_4 - EUKARYOTES_YPL211W	YPL211W	"NIP7 - Nucleolar protein required for 60S ribosome subunit biogenesis, constituent of 66S pre-ribosomal particles; physically interacts with Nop8p and the exosome subunit Rrp43p"	1	0	0	1	0.952380952	0.857142857	1	0.9375
1495_OG5_127883_4 - EUKARYOTES_YMR002W	YMR002W	"MIC17 - Mitochondrial intermembrane space protein, required for normal oxygen consumption; contains twin cysteine-x9-cysteine motifs"	1	0	0	1	0.80952381	1	1	0.5
1496_OG5_128027_4 - EUKARYOTES_YBL067C	YBL067C	"UBP13 - Putative ubiquitin carboxyl-terminal hydrolase, ubiquitin-specific protease that cleaves ubiquitin-protein fusions"	1	0	0	1	0.80952381	1	1	0.4375
1497_OG5_128027_4 - EUKARYOTES_YER098W	YER098W	"UBP9 - Ubiquitin carboxyl-terminal hydrolase, ubiquitin-specific protease that cleaves ubiquitin-protein fusions"	1	0	0	1	0.80952381	1	1	0.4375
1498_OG5_128081_4 - EUKARYOTES_YDL090C	YDL090C	RAM1 - Beta subunit of the CAAX farnesyltransferase (FTase) that prenylates the a-factor mating pheromone and Ras proteins; required for the membrane localization of Ras proteins and a-factor; homolog of the mammalian FTase beta subunit	1	0	0	1	0.952380952	0.857142857	1	0.875
1499_OG5_128130_4 - EUKARYOTES_YNL308C	YNL308C	KRI1 - Essential nucleolar protein required for 40S ribosome biogenesis; physically and functionally interacts with Krr1p	1	0	0	1	0.952380952	0.857142857	1	0.8125
1500_OG5_128132_4 - EUKARYOTES_YKL099C	YKL099C	UTP11 - Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit	1	0	0	1	0.952380952	0.857142857	1	0.9375
1501_OG5_128165_4 - EUKARYOTES_YHR148W	YHR148W	"IMP3 - Component of the SSU processome, which is required for pre-18S rRNA processing, essential protein that interacts with Mpp10p and mediates interactions of Imp4p and Mpp10p with U3 snoRNA"	1	0	0	1	0.952380952	0.857142857	1	0.875
1502_OG5_128187_4 - EUKARYOTES_YLL036C	YLL036C	"PRP19 - Splicing factor associated with the spliceosome; contains a U-box, a motif found in a class of ubiquitin ligases, and a WD40 domain"	1	0	0	1	0.80952381	1	1	0.75
1503_OG5_128241_4 - EUKARYOTES_YBR202W	YBR202W	"MCM7 - Component of the heterohexameric MCM2-7 complex, which primes origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation in S-phase; forms an Mcm4p-6p-7p subcomplex"	1	0	0	1	0.952380952	0.857142857	1	0.875
1504_OG5_128294_4 - EUKARYOTES_YGR285C	YGR285C	"ZUO1 - Ribosome-associated chaperone, functions in ribosome biogenesis and, in partnership with Ssz1p and SSb1/2, as a chaperone for nascent polypeptide chains; contains a DnaJ domain and functions as a J-protein partner for Ssb1p and Ssb2p"	1	0	0	1	0.80952381	1	1	0.75
1505_OG5_128422_4 - EUKARYOTES_YGL171W	YGL171W	ROK1 - ATP-dependent RNA helicase of the DEAD box family; required for 18S rRNA synthesis	1	0	0	1	0.80952381	1	1	0.75
1506_OG5_128548_4 - EUKARYOTES_YBR110W	YBR110W	"ALG1 - Mannosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum (ER); essential for viability, mutation is functionally complemented by human ortholog"	1	0	0	1	0.952380952	0.857142857	1	0.5625
1507_OG5_128580_4 - EUKARYOTES_YNL182C	YNL182C	"IPI3 - Essential component of the Rix1 complex (Rix1p, Ipi1p, Ipi3p) that is required for processing of ITS2 sequences from 35S pre-rRNA; highly conserved and contains WD40 motifs; Rix1 complex associates with Mdn1p in pre-60S ribosomal particles"	1	0	0	1	0.952380952	0.857142857	1	0.625
1508_OG5_128697_4 - EUKARYOTES_YML095C	YML095C	"RAD10 - Single-stranded DNA endonuclease (with Rad1p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human ERCC1 protein"	1	0	0	1	0.952380952	0.857142857	1	0.6875
1509_OG5_128771_4 - EUKARYOTES_YHL013C	YHL013C	"OTU2 - Protein of unknown function that may interact with ribosomes, based on co-purification experiments; member of the ovarian tumor-like (OTU) superfamily of predicted cysteine proteases; shows cytoplasmic localization"	1	0	0	1	0.80952381	1	1	0.625
1510_OG5_128790_4 - EUKARYOTES_YGL112C	YGL112C	"TAF6 - Subunit (60 kDa) of TFIID and SAGA complexes, involved in transcription initiation of RNA polymerase II and in chromatin modification, similar to histone H4"	1	0	0	1	0.952380952	0.857142857	1	0.3125
1511_OG5_128826_4 - EUKARYOTES_YDR177W	YDR177W	UBC1 - Ubiquitin-conjugating enzyme that mediates selective degradation of short-lived and abnormal proteins; plays a role in vesicle biogenesis and ER-associated protein degradation (ERAD); component of the cellular stress response	1	0	0	1	0.80952381	1	1	0.5
1512_OG5_128889_4 - EUKARYOTES_YMR203W	YMR203W	TOM40 - Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; constitutes the core element of the protein conducting pore	1	0	0	1	0.80952381	1	1	0.125
1513_OG5_128945_4 - EUKARYOTES_YJR031C	YJR031C	"GEA1 - Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs), involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; similar to but not functionally redundant with Gea2p"	1	0	0	1	0.80952381	1	1	0.1875
1514_OG5_128945_4 - EUKARYOTES_YEL022W	YEL022W	"GEA2 - Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs), involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; similar to but not functionally redundant with Gea1p"	1	0	0	1	0.80952381	1	1	0.1875
1515_OG5_129002_4 - EUKARYOTES_YLR459W	YLR459W	"GAB1 - GPI transamidase subunit, involved in attachment of glycosylphosphatidylinositol (GPI) anchors to proteins; may have a role in recognition of the attachment signal or of the lipid portion of GPI"	1	0	0	1	0.80952381	1	1	0.3125
1516_OG5_129020_4 - EUKARYOTES_YBR246W	YBR246W	RRT2 - Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; null mutants display a weak carboxypeptidase Y missorting/secretion phenotype	1	0	0	1	0.80952381	1	1	0.5625
1517_OG5_129179_4 - EUKARYOTES_YKL197C	YKL197C	PEX1 - AAA-peroxin that heterodimerizes with AAA-peroxin Pex6p and participates in the recycling of peroxisomal signal receptor Pex5p from the peroxisomal membrane to the cystosol; induced by oleic acid and upregulated during anaerobiosis	1	0	0	1	0.80952381	1	1	0.25
1518_OG5_129368_4 - EUKARYOTES_YBR097W	YBR097W	VPS15 - Myristoylated serine/threonine protein kinase involved in vacuolar protein sorting; functions as a membrane-associated complex with Vps34p; active form recruits Vps34p to the Golgi membrane; interacts with the GDP-bound form of Gpa1p	1	0	0	1	0.80952381	1	1	0.125
1519_OG5_129387_4 - EUKARYOTES_YER173W	YER173W	"RAD24 - Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; subunit of a clamp loader that loads Rad17p-Mec3p-Ddc1p onto DNA; homolog of human and S. pombe Rad17 protein"	1	0	0	1	0.80952381	1	1	0.1875
1520_OG5_129455_4 - EUKARYOTES_YMR268C	YMR268C	PRP24 - Splicing factor that reanneals U4 and U6 snRNPs during spliceosome recycling	1	0	0	1	0.80952381	1	1	0.1875
1521_OG5_129499_4 - EUKARYOTES_YIL068C	YIL068C	"SEC6 - Essential 88kDa subunit of the exocyst complex, which mediates polarized targeting of secretory vesicles to active sites of exocytosis; dimeric form of Sec6p interacts with Sec9p in vitro and inhibits t-SNARE assembly"	1	0	0	1	0.80952381	1	1	0.0625
1522_OG5_129591_4 - EUKARYOTES_YAR003W	YAR003W	"SWD1 - Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member with similarity to mammalian Rbbp7"	1	0	0	1	0.80952381	1	1	0.1875
1523_OG5_127101_4 - EUKARYOTES_YGL180W	YGL180W	ATG1 - Protein ser/thr kinase required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; structurally required for phagophore assembly site formation; during autophagy forms a complex with Atg13p and Atg17p	1	0	0	1	0.857142857	1	0.95	0.375
1524_OG5_127148_4 - EUKARYOTES_YEL056W	YEL056W	"HAT2 - Subunit of the Hat1p-Hat2p histone acetyltransferase complex; required for high affinity binding of the complex to free histone H4, thereby enhancing Hat1p activity; similar to human RbAp46 and 48; has a role in telomeric silencing"	1	0	0	1	0.857142857	1	0.95	0.8125
1525_OG5_127481_4 - EUKARYOTES_YKL117W	YKL117W	SBA1 - Co-chaperone that binds to and regulates Hsp90 family chaperones; important for pp60v-src activity in yeast; homologous to the mammalian p23 proteins and like p23 can regulate telomerase activity	1	0	0	1	0.857142857	1	0.95	0.875
1526_OG5_127650_4 - EUKARYOTES_YCL001W	YCL001W	"RER1 - Protein involved in retention of membrane proteins, including Sec12p, in the ER; localized to Golgi; functions as a retrieval receptor in returning membrane proteins to the ER"	1	0	0	1	0.857142857	1	0.95	0.9375
1527_OG5_127768_4 - EUKARYOTES_YLR410W	YLR410W	"VIP1 - Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase; IP7 production is important for phosphate signaling; involved in cortical actin cytoskeleton function, and invasive pseudohyphal growth analogous to S. pombe asp1"	1	0	0	1	0.857142857	1	0.95	0.625
1528_OG5_128049_4 - EUKARYOTES_YGL124C	YGL124C	"MON1 - Protein required for fusion of cvt-vesicles and autophagosomes with the vacuole; associates, as a complex with Ccz1p, with a perivacuolar compartment; potential Cdc28p substrate"	1	0	0	1	0.857142857	1	0.95	0.5625
1529_OG5_128184_4 - EUKARYOTES_YOR091W	YOR091W	TMA46 - Protein of unknown function that associates with translating ribosomes; interacts with GTPase Rbg1p	1	0	0	1	0.857142857	1	0.95	0.9375
1530_OG5_128615_4 - EUKARYOTES_YOL034W	YOL034W	SMC5 - Structural maintenance of chromosomes (SMC) protein; essential subunit of the Mms21-Smc5-Smc6 complex; required for growth and DNA repair; S. pombe homolog forms a heterodimer with S. pombe Rad18p that is involved in DNA repair	1	0	0	1	0.857142857	1	0.95	0.625
1531_OG5_128900_4 - EUKARYOTES_YHR099W	YHR099W	"TRA1 - Subunit of SAGA and NuA4 histone acetyltransferase complexes; interacts with acidic activators (e.g., Gal4p) which leads to transcription activation; similar to human TRRAP, which is a cofactor for c-Myc mediated oncogenic transformation"	1	0	0	1	0.857142857	1	0.95	0.4375
1532_OG5_129080_4 - EUKARYOTES_YBL008W	YBL008W	"HIR1 - Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; contributes to nucleosome formation, heterochromatic gene silencing, and formation of functional kinetochores"	1	0	0	1	1	0.857142857	0.95	0.3125
1533_OG5_129224_4 - EUKARYOTES_YDL108W	YDL108W	"KIN28 - Serine/threonine protein kinase, subunit of the transcription factor TFIIH; involved in transcription initiation at RNA polymerase II promoters"	1	0	0	1	0.857142857	1	0.95	0.25
1534_OG5_127391_4 - EUKARYOTES_YLR170C	YLR170C	"APS1 - Small subunit of the clathrin-associated adaptor complex AP-1, which is involved in protein sorting at the trans-Golgi network; homolog of the sigma subunit of the mammalian clathrin AP-1 complex"	1	0	0	1	0.904761905	1	0.9	0.75
1535_OG5_128980_4 - EUKARYOTES_YBR198C	YBR198C	"TAF5 - Subunit (90 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification"	1	0	0	1	0.904761905	1	0.9	0.5
1536_OG5_128988_4 - EUKARYOTES_YGR002C	YGR002C	SWC4 - Component of the Swr1p complex that incorporates Htz1p into chromatin; component of the NuA4 histone acetyltransferase complex	1	0	0	1	0.904761905	1	0.9	0.5625
1537_OG5_127577_4 - EUKARYOTES_YGR048W	YGR048W	"UFD1 - Protein that interacts with Cdc48p and Npl4p, involved in recognition of polyubiquitinated proteins and their presentation to the 26S proteasome for degradation; involved in transporting proteins from the ER to the cytosol"	1	0	0	0.875	1	0.928571429	1	1
1538_OG5_127840_4 - EUKARYOTES_YLR147C	YLR147C	"SMD3 - Core Sm protein Sm D3; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D3"	1	0	0	0.875	1	0.928571429	1	0.875
1539_OG5_127866_4 - EUKARYOTES_YPR112C	YPR112C	MRD1 - Essential conserved protein that is part of the 90S preribosome; required for production of 18S rRNA and small ribosomal subunit; contains five consensus RNA-binding domains	1	0	0	0.875	1	0.928571429	1	0.9375
1540_OG5_128735_4 - EUKARYOTES_YPL117C	YPL117C	"IDI1 - Isopentenyl diphosphate:dimethylallyl diphosphate isomerase (IPP isomerase), catalyzes an essential activation step in the isoprenoid biosynthetic pathway; required for viability"	1	0.1875	0.111111111	1	0.857142857	0.928571429	1	0.3125
1541_OG5_127927_4 - EUKARYOTES_YDR021W	YDR021W	"FAL1 - Nucleolar protein required for maturation of 18S rRNA, member of the eIF4A subfamily of DEAD-box ATP-dependent RNA helicases"	1	0.1875	0.083333333	1	0.857142857	0.928571429	1	0.8125
1542_OG5_128089_4 - EUKARYOTES_YPR131C	YPR131C	"NAT3 - Catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes acetylation of the amino-terminal methionine residues of all proteins beginning with Met-Asp or Met-Glu and of some proteins beginning with Met-Asn or Met-Met"	1	0.0625	0.055555556	1	0.857142857	0.928571429	1	0.9375
1543_OG5_128124_4 - EUKARYOTES_YJR070C	YJR070C	"LIA1 - Deoxyhypusine hydroxylase, a HEAT-repeat containing metalloenzyme that catalyzes hypusine formation; binds to and is required for the modification of Hyp2p (eIF5A); complements S. pombe mmd1 mutants defective in mitochondrial positioning"	1	0.0625	0.055555556	1	0.857142857	0.928571429	1	0.875
1544_OG5_128426_4 - EUKARYOTES_YER141W	YER141W	"COX15 - Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase"	1	0	0.111111111	1	0.857142857	0.928571429	1	0.625
1545_OG5_128070_4 - EUKARYOTES_YIL061C	YIL061C	SNP1 - Component of U1 snRNP required for mRNA splicing via spliceosome; substrate of the arginine methyltransferase Hmt1p; may interact with poly(A) polymerase to regulate polyadenylation; homolog of human U1 70K protein	1	0	0.027777778	1	0.857142857	0.928571429	1	0.75
1546_OG5_129449_4 - EUKARYOTES_YDR299W	YDR299W	BFR2 - Essential protein that is a component of 90S preribosomes; may be involved in rRNA processing; multicopy suppressor of sensitivity to Brefeldin A; expression is induced during lag phase and also by cold shock	1	0	0.027777778	1	0.857142857	0.928571429	1	0.1875
1547_OG5_128297_4 - EUKARYOTES_YJR013W	YJR013W	"GPI14 - Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M"	1	0.0625	0	1	0.857142857	0.928571429	1	0.6875
1548_OG5_127767_4 - EUKARYOTES_YDL015C	YDL015C	"TSC13 - Enoyl reductase that catalyzes the last step in each cycle of very long chain fatty acid elongation, localizes to the ER, highly enriched in a structure marking nuclear-vacuolar junctions, coimmunoprecipitates with elongases Fen1p and Sur4p"	1	0	0	1	0.857142857	0.928571429	1	0.8125
1549_OG5_127771_4 - EUKARYOTES_YGL087C	YGL087C	"MMS2 - Ubiquitin-conjugating enzyme variant involved in error-free postreplication repair; forms a heteromeric complex with Ubc13p, an active ubiquitin-conjugating enzyme; cooperates with chromatin-associated RING finger proteins, Rad18p and Rad5p"	1	0	0	1	0.857142857	0.928571429	1	0.75
1550_OG5_127794_4 - EUKARYOTES_YNL263C	YNL263C	"YIF1 - Integral membrane protein required for the fusion of ER-derived COPII transport vesicles with the Golgi; interacts with Yip1p and Yos1p; localizes to the Golgi, the ER, and COPII vesicles"	1	0	0	1	0.857142857	0.928571429	1	0.75
1551_OG5_127951_4 - EUKARYOTES_YGL054C	YGL054C	"ERV14 - Protein localized to COPII-coated vesicles, involved in vesicle formation and incorporation of specific secretory cargo; required for the delivery of bud-site selection protein Axl2p to cell surface; related to Drosophila cornichon"	1	0	0	1	0.857142857	0.928571429	1	0.1875
1552_OG5_127980_4 - EUKARYOTES_YHR162W	YHR162W	YHR162W - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion	1	0	0	1	0.857142857	0.928571429	1	0.5625
1553_OG5_127980_4 - EUKARYOTES_YGR243W	YGR243W	"FMP43 - Putative protein of unknown function; expression regulated by osmotic and alkaline stresses; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"	1	0	0	1	0.857142857	0.928571429	1	0.5625
1554_OG5_128037_4 - EUKARYOTES_YDR214W	YDR214W	AHA1 - Co-chaperone that binds to Hsp82p and activates its ATPase activity; similar to Hch1p; expression is regulated by stresses such as heat shock	1	0	0	1	0.857142857	0.928571429	1	0.5625
1555_OG5_128073_4 - EUKARYOTES_YFR052W	YFR052W	"RPN12 - Subunit of the 19S regulatory particle of the 26S proteasome lid; synthetically lethal with RPT1, which is an ATPase component of the 19S regulatory particle; physically interacts with Nob1p and Rpn3p"	1	0	0	1	0.857142857	0.928571429	1	0.6875
1556_OG5_128169_4 - EUKARYOTES_YMR290C	YMR290C	HAS1 - ATP-dependent RNA helicase; localizes to both the nuclear periphery and nucleolus; highly enriched in nuclear pore complex fractions; constituent of 66S pre-ribosomal particles	1	0	0	1	1	0.785714286	1	0.8125
1557_OG5_128292_4 - EUKARYOTES_YLR276C	YLR276C	DBP9 - ATP-dependent RNA helicase of the DEAD-box family involved in biogenesis of the 60S ribosomal subunit	1	0	0	1	0.857142857	0.928571429	1	0.8125
1558_OG5_128306_4 - EUKARYOTES_YGR091W	YGR091W	"PRP31 - Splicing factor, component of the U4/U6-U5 snRNP complex"	1	0	0	1	0.857142857	0.928571429	1	0.8125
1559_OG5_128335_4 - EUKARYOTES_YJR050W	YJR050W	"ISY1 - Member of NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of spliceosome containing U2, U5, and U6 snRNAs, interacts with Prp16p to modulate splicing fidelity; isy1 syf2 cells have defective spindles"	1	0	0	1	0.857142857	0.928571429	1	0.8125
1560_OG5_128430_4 - EUKARYOTES_YJL203W	YJL203W	"PRP21 - Subunit of the SF3a splicing factor complex, required for spliceosome assembly"	1	0	0	1	0.857142857	0.928571429	1	0.625
1561_OG5_128447_4 - EUKARYOTES_YOL062C	YOL062C	APM4 - Mu2-like subunit of the clathrin associated protein complex (AP-2); involved in vesicle transport	1	0	0	1	0.857142857	0.928571429	1	0.5
1562_OG5_128455_4 - EUKARYOTES_YHR172W	YHR172W	SPC97 - Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque	1	0	0	1	0.857142857	0.928571429	1	0.6875
1563_OG5_128485_4 - EUKARYOTES_YMR236W	YMR236W	"TAF9 - Subunit (17 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H3"	1	0	0	1	0.857142857	0.928571429	1	0.3125
1564_OG5_128770_4 - EUKARYOTES_YPL065W	YPL065W	"VPS28 - Component of the ESCRT-I complex (Stp22p, Srn2p, Vps28p, and Mvb12p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; conserved C-terminal domain interacts with ESCRT-III subunit Vps20p"	1	0	0	1	0.857142857	0.928571429	1	0.4375
1565_OG5_128820_4 - EUKARYOTES_YLR418C	YLR418C	"CDC73 - Component of the Paf1p complex that binds to and modulates the activity of RNA polymerases I and II; required for expression of certain genes, modification of some histones, and telomere maintenance"	1	0	0	1	0.857142857	0.928571429	1	0.375
1566_OG5_128831_4 - EUKARYOTES_YHL010C	YHL010C	"ETP1 - Putative protein of unknown function that is required for growth on ethanol; contains a zinc finger region and has homology to human BRAP2, which is a cytoplasmic protein that binds nuclear localization sequences"	1	0	0	1	0.857142857	0.928571429	1	0.375
1567_OG5_128834_4 - EUKARYOTES_YGR006W	YGR006W	"PRP18 - Splicing factor involved in the positioning of the 3' splice site during the second catalytic step of splicing, part of snRNP U5, interacts with Slu7p"	1	0	0	1	0.857142857	0.928571429	1	0.625
1568_OG5_128887_4 - EUKARYOTES_YPL122C	YPL122C	"TFB2 - Subunit of TFIIH and nucleotide excision repair factor 3 complexes, involved in transcription initiation, required for nucleotide excision repair, similar to 52 kDa subunit of human TFIIH"	1	0	0	1	1	0.785714286	1	0.3125
1569_OG5_129085_4 - EUKARYOTES_YJL030W	YJL030W	"MAD2 - Component of the spindle-assembly checkpoint complex, which delays the onset of anaphase in cells with defects in mitotic spindle assembly; forms a complex with Mad1p"	1	0	0	1	0.857142857	0.928571429	1	0.375
1570_OG5_129089_4 - EUKARYOTES_YNL252C	YNL252C	MRPL17 - Mitochondrial ribosomal protein of the large subunit	1	0	0	1	0.857142857	0.928571429	1	0.3125
1571_OG5_129207_4 - EUKARYOTES_YLR192C	YLR192C	HCR1 - Dual function protein involved in translation initiation as a substoichiometric component (eIF3j) of translation initiation factor 3 (eIF3) and required for processing of 20S pre-rRNA; binds to eIF3 subunits Rpg1p and Prt1p and 18S rRNA	1	0	0	1	0.857142857	0.928571429	1	0.1875
1572_OG5_129292_4 - EUKARYOTES_YGR112W	YGR112W	SHY1 - Mitochondrial inner membrane protein required for assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes; similar to human SURF1 involved in Leigh Syndrome	1	0	0.166666667	1	0.904761905	0.928571429	0.95	0.0625
1573_OG5_128511_4 - EUKARYOTES_YIR012W	YIR012W	SQT1 - Essential protein involved in a late step of 60S ribosomal subunit assembly or modification; contains multiple WD repeats; interacts with Qsr1p in a two-hybrid assay	1	0	0.027777778	1	0.904761905	0.928571429	0.95	0.4375
1574_OG5_127484_4 - EUKARYOTES_YKR057W	YKR057W	RPS21A - Protein component of the small (40S) ribosomal subunit; nearly identical to Rps21Bp and has similarity to rat S21 ribosomal protein	1	0	0	1	0.904761905	0.928571429	0.95	0.8125
1575_OG5_127484_4 - EUKARYOTES_YJL136C	YJL136C	RPS21B - Protein component of the small (40S) ribosomal subunit; nearly identical to Rps21Ap and has similarity to rat S21 ribosomal protein	1	0	0	1	0.904761905	0.928571429	0.95	0.8125
1576_OG5_127780_4 - EUKARYOTES_YLR396C	YLR396C	"VPS33 - ATP-binding protein that is a subunit of the HOPS complex and of the CORVET tethering complex; essential for protein sorting, vesicle docking and fusion at the vacuole"	1	0	0	1	0.904761905	0.928571429	0.95	0.75
1577_OG5_127874_4 - EUKARYOTES_YJR006W	YJR006W	"POL31 - DNA polymerase III (delta) subunit, essential for cell viability; involved in DNA replication and DNA repair"	1	0	0	1	0.904761905	0.928571429	0.95	1
1578_OG5_128120_4 - EUKARYOTES_YPL046C	YPL046C	"ELC1 - Elongin C, involved in transcription elongation as a heterodimer with Ela1p; forms a complex with Cul3p that polyubiquitylates monoubiquitylated RNA polymerase II to trigger its proteolysis; plays a role in global genomic repair"	1	0	0	1	0.904761905	0.928571429	0.95	0.4375
1579_OG5_128178_4 - EUKARYOTES_YPL043W	YPL043W	"NOP4 - Nucleolar protein, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; contains four RNA recognition motifs (RRMs)"	1	0	0	1	0.904761905	0.928571429	0.95	0.6875
1580_OG5_128208_4 - EUKARYOTES_YDL060W	YDL060W	"TSR1 - Protein required for processing of 20S pre-rRNA in the cytoplasm, associates with pre-40S ribosomal particles"	1	0	0	1	0.904761905	0.928571429	0.95	1
1581_OG5_128773_4 - EUKARYOTES_YHR166C	YHR166C	"CDC23 - Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition"	1	0	0	1	0.904761905	0.928571429	0.95	0.5
1582_OG5_128134_4 - EUKARYOTES_YEL032W	YEL032W	MCM3 - Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex	1	0	0	1	0.952380952	0.928571429	0.9	1
1583_OG5_127789_4 - EUKARYOTES_YJL074C	YJL074C	"SMC3 - Subunit of the multiprotein cohesin complex required for sister chromatid cohesion in mitotic cells; also required, with Rec8p, for cohesion and recombination during meiosis; phylogenetically conserved SMC chromosomal ATPase family member"	1	0	0.083333333	0.875	0.904761905	1	1	0.875
1584_OG5_128946_4 - EUKARYOTES_YJL180C	YJL180C	ATP12 - Conserved protein required for assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase; mutation of human ATP12 reduces active ATP synthase levels and is associated with the disorder ATPAF2 deficiency	1	0	0.055555556	0.875	0.904761905	1	1	0.3125
1585_OG5_127111_4 - EUKARYOTES_YNL223W	YNL223W	ATG4 - Conserved cysteine protease required for autophagy; cleaves Atg8p to a form required for autophagosome and Cvt vesicle generation	1	0	0.027777778	0.875	0.904761905	1	1	0.3125
1586_OG5_128162_4 - EUKARYOTES_YLR260W	YLR260W	"LCB5 - Minor sphingoid long-chain base kinase, paralog of Lcb4p responsible for few percent of the total activity, possibly involved in synthesis of long-chain base phosphates, which function as signaling molecules"	1	0	0.027777778	0.875	0.904761905	1	1	0.125
1587_OG5_128162_4 - EUKARYOTES_YOR171C	YOR171C	"LCB4 - Sphingoid long-chain base kinase, responsible for synthesis of long-chain base phosphates, which function as signaling molecules, regulates synthesis of ceramide from exogenous long-chain bases, localizes to the Golgi and late endosomes"	1	0	0.027777778	0.875	0.904761905	1	1	0.125
1588_OG5_128210_4 - EUKARYOTES_YDR211W	YDR211W	"GCD6 - Catalytic epsilon subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression"	1	0	0.027777778	0.875	0.904761905	1	1	0.875
1589_OG5_128392_4 - EUKARYOTES_YML102W	YML102W	"CAC2 - Component of the chromatin assembly complex (with Rlf2p and Msi1p) that assembles newly synthesized histones onto recently replicated DNA, required for building functional kinetochores, conserved from yeast to humans"	1	0	0.027777778	0.875	0.904761905	1	1	0.6875
1590_OG5_129360_4 - EUKARYOTES_YLR384C	YLR384C	"IKI3 - Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD)"	1	0	0.027777778	0.875	0.904761905	1	1	0.1875
1591_OG5_127702_4 - EUKARYOTES_YOL006C	YOL006C	"TOP1 - Topoisomerase I, nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication, transcription, and recombination"	1	0.0625	0	0.875	0.904761905	1	1	0.75
1592_OG5_126829_4 - EUKARYOTES_YBL049W	YBL049W	"MOH1 - Protein of unknown function, has homology to kinase Snf7p; not required for growth on nonfermentable carbon sources; essential for survival in stationary phase"	1	0	0	0.875	0.904761905	1	1	0.6875
1593_OG5_127364_4 - EUKARYOTES_YKL068W	YKL068W	NUP100 - Subunit of the nuclear pore complex (NPC) that is localized to both sides of the pore; contains a repetitive GLFG motif that interacts with mRNA export factor Mex67p and with karyopherin Kap95p; homologous to Nup116p	1	0	0	0.875	0.904761905	1	1	0.9375
1594_OG5_127364_4 - EUKARYOTES_YMR047C	YMR047C	NUP116 - Subunit of the Nup82 subcomplex of the nuclear pore complex; localized to both sides of the pore; contains a repetitive GLFG motif that interacts with mRNA export factor Mex67p and with karyopherin Kap95p; homologous to Nup100p	1	0	0	0.875	0.904761905	1	1	0.9375
1595_OG5_127453_4 - EUKARYOTES_YDR164C	YDR164C	SEC1 - Sm-like protein involved in docking and fusion of exocytic vesicles; binds to assembled SNARE complexes at the membrane and stimulates membrane fusion; localization to sites of secretion (bud neck and bud tip) is dependent on SNARE function	1	0	0	0.875	0.904761905	1	1	0.875
1596_OG5_127604_4 - EUKARYOTES_YPR129W	YPR129W	SCD6 - Protein containing an Lsm domain; negatively regulates translation initiation via 48S preinitiation complex assembly; may bind RNA and have a role in RNA processing; overproduction suppresses null mutation in clathrin heavy chain gene CHC1	1	0	0	0.875	0.904761905	1	1	0.75
1597_OG5_127803_4 - EUKARYOTES_YAL042W	YAL042W	"ERV46 - Protein localized to COPII-coated vesicles, forms a complex with Erv41p; involved in the membrane fusion stage of transport"	1	0	0	0.875	0.904761905	1	1	0.4375
1598_OG5_127875_4 - EUKARYOTES_YKL212W	YKL212W	"SAC1 - Phosphatidylinositol phosphate (PtdInsP) phosphatase involved in hydrolysis of PtdIns[4]P; transmembrane protein localizes to ER and Golgi; involved in protein trafficking and processing, secretion, and cell wall maintenance"	1	0	0	0.875	0.904761905	1	1	0.625
1599_OG5_127958_4 - EUKARYOTES_YBR236C	YBR236C	"ABD1 - Methyltransferase, catalyzes the transfer of a methyl group from S-adenosylmethionine to the GpppN terminus of capped mRNA"	1	0	0	0.875	0.904761905	1	1	1
1600_OG5_127963_4 - EUKARYOTES_YOR057W	YOR057W	SGT1 - Cochaperone protein; regulates activity of adenylyl cyclase Cyr1p; involved in kinetochore complex assembly; associates with the SCF (Skp1p/Cdc53p/F box protein) ubiquitin ligase complex; acts as a linker between Skp1p and HSP90 complexes	1	0	0	0.875	0.904761905	1	1	0.75
1601_OG5_128128_4 - EUKARYOTES_YKR068C	YKR068C	BET3 - Hydrophilic protein that acts in conjunction with SNARE proteins in targeting and fusion of ER to Golgi transport vesicles; component of the TRAPP (transport protein particle) complex	1	0	0	0.875	0.904761905	1	1	0.875
1602_OG5_128231_4 - EUKARYOTES_YOR319W	YOR319W	HSH49 - U2-snRNP associated splicing factor with similarity to the mammalian splicing factor SAP49; proposed to function as a U2-snRNP assembly factor along with Hsh155p and binding partner Cus1p; contains two RNA recognition motifs (RRM)	1	0	0	0.875	0.904761905	1	1	0.8125
1603_OG5_128270_4 - EUKARYOTES_YLR196W	YLR196W	PWP1 - Protein with WD-40 repeats involved in rRNA processing; associates with trans-acting ribosome biogenesis factors; similar to beta-transducin superfamily	1	0	0	0.875	0.904761905	1	1	0.75
1604_OG5_128283_4 - EUKARYOTES_YIR005W	YIR005W	"IST3 - Component of the U2 snRNP, required for the first catalytic step of splicing and for spliceosomal assembly; interacts with Rds3p and is required for Mer1p-activated splicing"	1	0	0	0.875	0.904761905	1	1	0.75
1605_OG5_128357_4 - EUKARYOTES_YAL032C	YAL032C	PRP45 - Protein required for pre-mRNA splicing; associates with the spliceosome and interacts with splicing factors Prp22p and Prp46p; orthologous to human transcriptional coactivator SKIP and can activate transcription of a reporter gene	1	0	0	0.875	0.904761905	1	1	0.8125
1606_OG5_128517_4 - EUKARYOTES_YPL210C	YPL210C	SRP72 - Core component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane	1	0	0	0.875	0.904761905	1	1	0.75
1607_OG5_128710_4 - EUKARYOTES_YNR021W	YNR021W	YNR021W - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YNR021W is not an essential gene	1	0	0	0.875	0.904761905	1	1	0.5
1608_OG5_128953_4 - EUKARYOTES_YJL090C	YJL090C	DPB11 - Replication initiation protein that loads DNA pol epsilon onto pre-replication complexes at origins; checkpoint sensor recruited to stalled replication forks by the checkpoint clamp complex where it activates Mec1p; ortholog of human TopBP1	1	0	0	0.875	0.904761905	1	1	0.125
1609_OG5_127434_4 - EUKARYOTES_YBL024W	YBL024W	"NCL1 - S-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase, methylates cytosine to m5C at several positions in tRNAs and intron-containing pre-tRNAs; similar to Nop2p and human proliferation associated nucleolar protein p120"	1	0	0	0.875	0.952380952	1	0.95	1
1610_OG5_127988_4 - EUKARYOTES_YPL178W	YPL178W	"CBC2 - Small subunit of the heterodimeric cap binding complex that also contains Sto1p, component of the spliceosomal commitment complex; interacts with Npl3p, possibly to package mRNA for export from the nucleus; contains an RNA-binding motif"	1	0	0	0.875	0.952380952	1	0.95	0.9375
1611_OG5_128227_4 - EUKARYOTES_YPR137W	YPR137W	"RRP9 - Protein involved in pre-rRNA processing, associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protein"	1	0	0	0.875	0.952380952	1	0.95	0.75
1612_OG5_128527_4 - EUKARYOTES_YML096W	YML096W	YML096W - Putative protein of unknown function with similarity to asparagine synthetases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YML096W is not an essential gene and partially overlaps the verified gene RAD10	1	0	0	0.875	0.952380952	1	0.95	0.5625
1613_OG5_127975_4 - EUKARYOTES_YFL036W	YFL036W	RPO41 - Mitochondrial RNA polymerase; single subunit enzyme similar to those of T3 and T7 bacteriophages; requires a specificity subunit encoded by MTF1 for promoter recognition	1	0	0.055555556	1	0.904761905	0.857142857	1	0.6875
1614_OG5_127842_4 - EUKARYOTES_YDR410C	YDR410C	"STE14 - Farnesyl cysteine-carboxyl methyltransferase, mediates the carboxyl methylation step during C-terminal CAAX motif processing of a-factor and RAS proteins in the endoplasmic reticulum, localizes to the ER membrane"	1	0	0.027777778	1	0.904761905	0.857142857	1	0.5625
1615_OG5_128538_4 - EUKARYOTES_YML097C	YML097C	VPS9 - A guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport; specifically stimulates the intrinsic guanine nucleotide exchange activity of Vps21p/Rab5: similar to mammalian ras inhibitors; binds ubiquitin	1	0	0.027777778	1	0.761904762	1	1	0.625
1616_OG5_127438_4 - EUKARYOTES_YDL084W	YDL084W	SUB2 - Component of the TREX complex required for nuclear mRNA export; member of the DEAD-box RNA helicase superfamily and is involved in early and late steps of spliceosome assembly; homolog of the human splicing factor hUAP56	1	0	0	1	0.904761905	0.857142857	1	0.875
1617_OG5_127638_4 - EUKARYOTES_YMR161W	YMR161W	"HLJ1 - Co-chaperone for Hsp40p, anchored in the ER membrane; with its homolog Ydj1p promotes ER-associated protein degradation (ERAD) of integral membrane substrates; similar to E. coli DnaJ"	1	0	0	1	0.904761905	0.857142857	1	0.75
1618_OG5_127686_4 - EUKARYOTES_YGR172C	YGR172C	"YIP1 - Integral membrane protein required for the biogenesis of ER-derived COPII transport vesicles; interacts with Yif1p and Yos1p; localizes to the Golgi, the ER, and COPII vesicles"	1	0	0	1	0.761904762	1	1	1
1619_OG5_127714_4 - EUKARYOTES_YDR002W	YDR002W	"YRB1 - Ran GTPase binding protein; involved in nuclear protein import and RNA export, ubiquitin-mediated protein degradation during the cell cycle; shuttles between the nucleus and cytoplasm; is essential; homolog of human RanBP1"	1	0	0	1	0.761904762	1	1	0.9375
1620_OG5_127760_4 - EUKARYOTES_YGL137W	YGL137W	"SEC27 - Essential beta'-coat protein of the COPI coatomer, involved in ER-to-Golgi and Golgi-to-ER transport; contains WD40 domains that mediate cargo selective interactions; 45% sequence identity to mammalian beta'-COP"	1	0	0	1	0.904761905	0.857142857	1	0.9375
1621_OG5_127918_4 - EUKARYOTES_YLR427W	YLR427W	MAG2 - Cytoplasmic protein of unknown function; induced in response to mycotoxin patulin; ubiquitinated protein similar to the human ring finger motif protein RNF10; predicted to be involved in repair of alkylated DNA due to interaction with MAG1	1	0	0	1	0.761904762	1	1	0.6875
1622_OG5_127921_4 - EUKARYOTES_YDR484W	YDR484W	"VPS52 - Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; involved in localization of actin and chitin"	1	0	0	1	0.904761905	0.857142857	1	0.75
1623_OG5_128033_4 - EUKARYOTES_YHR098C	YHR098C	"SFB3 - Component of the Sec23p-Sfb3p heterodimer of the COPII vesicle coat, required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sec24p and Sfb2p"	1	0	0	1	0.761904762	1	1	0.4375
1624_OG5_128074_4 - EUKARYOTES_YDR472W	YDR472W	TRS31 - One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic	1	0	0	1	0.904761905	0.857142857	1	1
1625_OG5_128167_4 - EUKARYOTES_YNR051C	YNR051C	"BRE5 - Ubiquitin protease cofactor, forms deubiquitination complex with Ubp3p that coregulates anterograde and retrograde transport between the endoplasmic reticulum and Golgi compartments; null is sensitive to brefeldin A"	1	0	0	1	0.761904762	1	1	0.25
1626_OG5_128182_4 - EUKARYOTES_YDR496C	YDR496C	"PUF6 - Pumilio-homology domain protein that binds the 3' UTR of ASH1 mRNA and represses its translation, resulting in proper asymmetric localization of ASH1 mRNA; also co-sediments with the 60S ribosomal subunit and is required for its biogenesis"	1	0	0	1	0.904761905	0.857142857	1	0.8125
1627_OG5_128216_4 - EUKARYOTES_YNL126W	YNL126W	SPC98 - Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque	1	0	0	1	0.761904762	1	1	0.8125
1628_OG5_128379_4 - EUKARYOTES_YKL179C	YKL179C	COY1 - Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function	1	0	0	1	0.761904762	1	1	0.25
1629_OG5_128453_4 - EUKARYOTES_YER154W	YER154W	"OXA1 - Mitochondrial inner membrane insertase, mediates the insertion of both mitochondrial- and nuclear-encoded proteins from the matrix into the inner membrane, interacts with mitochondrial ribosomes; conserved from bacteria to animals"	1	0	0	1	0.904761905	0.857142857	1	0.5
1630_OG5_128521_4 - EUKARYOTES_YDR419W	YDR419W	"RAD30 - DNA polymerase eta, involved in translesion synthesis during post-replication repair; catalyzes the synthesis of DNA opposite cyclobutane pyrimidine dimers and other lesions; mutations in human pol eta are responsible for XPV"	1	0	0	1	0.761904762	1	1	0.5
1631_OG5_128819_4 - EUKARYOTES_YPR048W	YPR048W	"TAH18 - Conserved NAPDH-dependent diflavin reductase, component of an early step in the cytosolic Fe-S protein assembly (CIA) machinery; transfers electrons from NADPH to the Fe-S cluster of Dre2p; plays a pro-death role under oxidative stress"	1	0	0	1	0.904761905	0.857142857	1	0.75
1632_OG5_128976_4 - EUKARYOTES_YOR206W	YOR206W	"NOC2 - Protein that forms a nucleolar complex with Mak21p that binds to 90S and 66S pre-ribosomes, as well as a nuclear complex with Noc3p that binds to 66S pre-ribosomes; both complexes mediate intranuclear transport of ribosomal precursors"	1	0	0	1	0.904761905	0.857142857	1	0.3125
1633_OG5_129062_4 - EUKARYOTES_YDL105W	YDL105W	NSE4 - Nuclear protein that plays a role in the function of the Smc5p-Rhc18p complex	1	0	0	1	0.761904762	1	1	0.1875
1634_OG5_129339_4 - EUKARYOTES_YDL028C	YDL028C	"MPS1 - Dual-specificity kinase required for spindle pole body (SPB) duplication and spindle checkpoint function; substrates include SPB proteins Spc42p, Spc110p, and Spc98p, mitotic exit network protein Mob1p, and checkpoint protein Mad1p"	1	0	0	1	0.761904762	1	1	0.3125
1635_OG5_129621_4 - EUKARYOTES_YDL148C	YDL148C	"NOP14 - Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA"	1	0	0	1	0.904761905	0.857142857	1	0.1875
1636_OG5_128689_4 - EUKARYOTES_YOL071W	YOL071W	"EMI5 - Subunit of succinate dehydrogenase, which couples succinate oxidation to ubiquinone reduction; required for FAD cofactor attachment to Sdh1p; mutations in human ortholog PGL2 are associated with neuroendocrine tumors (paraganglioma)"	1	0	0.138888889	1	0.80952381	1	0.95	0.375
1637_OG5_128307_4 - EUKARYOTES_YER140W	YER140W	"YER140W - Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; genetic interactions suggest a role in folding of ER membrane proteins"	1	0	0.027777778	1	0.80952381	1	0.95	0.75
1638_OG5_128064_4 - EUKARYOTES_YPR182W	YPR182W	"SMX3 - Core Sm protein Sm F; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm F"	1	0.0625	0	1	0.952380952	0.857142857	0.95	0.9375
1639_OG5_126885_4 - EUKARYOTES_YPL154C	YPL154C	"PEP4 - Vacuolar aspartyl protease (proteinase A), required for the posttranslational precursor maturation of vacuolar proteinases; important for protein turnover after oxidative damage; synthesized as a zymogen, self-activates"	1	0	0	1	0.80952381	1	0.95	0.625
1640_OG5_127469_4 - EUKARYOTES_YBR135W	YBR135W	"CKS1 - Cyclin-dependent protein kinase regulatory subunit and adaptor; modulates proteolysis of M-phase targets through interactions with the proteasome; role in transcriptional regulation, recruiting proteasomal subunits to target gene promoters"	1	0	0	1	0.952380952	0.857142857	0.95	0.75
1641_OG5_127473_4 - EUKARYOTES_YPR028W	YPR028W	YOP1 - Membrane protein that interacts with Yip1p to mediate membrane traffic; interacts with Sey1p to maintain ER morphology; overexpression leads to cell death and accumulation of internal cell membranes	1	0	0	1	0.80952381	1	0.95	0.75
1642_OG5_127920_4 - EUKARYOTES_YOR175C	YOR175C	"ALE1 - Broad-specificity lysophospholipid acyltransferase, part of MBOAT family of membrane-bound O-acyltransferases; key component of Lands cycle; may have role in fatty acid exchange at sn-2 position of mature glycerophospholipids"	1	0	0	1	0.80952381	1	0.95	0.25
1643_OG5_128243_4 - EUKARYOTES_YGL070C	YGL070C	RPB9 - RNA polymerase II subunit B12.6; contacts DNA; mutations affect transcription start site selection and fidelity of transcription	1	0	0	1	0.952380952	0.857142857	0.95	0.875
1644_OG5_128268_4 - EUKARYOTES_YER100W	YER100W	UBC6 - Ubiquitin-conjugating enzyme involved in ER-associated protein degradation; located at the cytosolic side of the ER membrane; tail region contains a transmembrane segment at the C-terminus; substrate of the ubiquitin-proteasome pathway	1	0	0	1	0.80952381	1	0.95	0.5
1645_OG5_128313_4 - EUKARYOTES_YMR049C	YMR049C	"ERB1 - Constituent of 66S pre-ribosomal particles, forms a complex with Nop7p and Ytm1p that is required for maturation of the large ribosomal subunit; required for maturation of the 25S and 5.8S ribosomal RNAs; homologous to mammalian Bop1"	1	0	0	1	0.952380952	0.857142857	0.95	0.8125
1646_OG5_128339_4 - EUKARYOTES_YOR100C	YOR100C	"CRC1 - Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation"	1	0	0	1	0.80952381	1	0.95	0.3125
1647_OG5_128348_4 - EUKARYOTES_YMR131C	YMR131C	RRB1 - Essential nuclear protein involved in early steps of ribosome biogenesis; physically interacts with the ribosomal protein Rpl3p	1	0	0	1	0.952380952	0.857142857	0.95	0.875
1648_OG5_128393_4 - EUKARYOTES_YAL058W	YAL058W	"CNE1 - Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p, with which Cne1p interacts; 24% identical to mammalian calnexin; Ca+ binding not yet shown in yeast"	1	0	0	1	0.80952381	1	0.95	0.3125
1649_OG5_128398_4 - EUKARYOTES_YJR105W	YJR105W	"ADO1 - Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle"	1	0	0	1	0.80952381	1	0.95	0.5625
1650_OG5_128417_4 - EUKARYOTES_YJR005C-A	YJR005C-A	"YJR005C-A - Putative protein of unknown function, originally identified as a syntenic homolog of an <i>Ashbya gossypii</i> gene"	1	0	0	1	0.80952381	1	0.95	0.6875
1651_OG5_128567_4 - EUKARYOTES_YFL002C	YFL002C	"SPB4 - Putative ATP-dependent RNA helicase, nucleolar protein required for synthesis of 60S ribosomal subunits at a late step in the pathway; sediments with 66S pre-ribosomes in sucrose gradients"	1	0	0	1	0.80952381	1	0.95	0.75
1652_OG5_128733_4 - EUKARYOTES_YER007W	YER007W	"PAC2 - Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl"	1	0	0	1	0.80952381	1	0.95	0.5625
1653_OG5_128940_4 - EUKARYOTES_YMR039C	YMR039C	"SUB1 - Transcriptional coactivator, facilitates elongation through factors that modify RNAP II; role in peroxide resistance involving Rad2p; role in the hyperosmotic stress response through polymerase recruitment at RNAP II and RNAP III genes"	1	0	0	1	0.80952381	1	0.95	0.1875
1654_OG5_129086_4 - EUKARYOTES_YMR284W	YMR284W	"YKU70 - Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair"	1	0	0	1	0.80952381	1	0.95	0.375
1655_OG5_129691_4 - EUKARYOTES_YPR040W	YPR040W	"TIP41 - Protein that interacts physically and genetically with Tap42p, which regulates protein phosphatase 2A; component of the TOR (target of rapamycin) signaling pathway"	1	0	0	1	0.80952381	1	0.95	0.125
1656_OG5_128844_4 - EUKARYOTES_YOR260W	YOR260W	"GCD1 - Gamma subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression"	1	0	0	1	0.857142857	1	0.9	0.5625
1657_OG5_128833_4 - EUKARYOTES_YPR045C	YPR045C	THP3 - Protein that forms a complex with Csn12p that is recruited to transcribed genes and may have a role in transcription elongation; possibly involved in splicing based on pre-mRNA accumulation defect for many intron-containing genes	1	0	0	0.875	0.952380952	0.928571429	1	0.375
1658_OG5_127313_4 - EUKARYOTES_YDR183W	YDR183W	"PLP1 - Protein that interacts with CCT (chaperonin containing TCP-1) complex and has a role in actin and tubulin folding; has weak similarity to phosducins, which are G-protein regulators"	1	0	0	1	0.904761905	1	0.85	0.9375
1659_OG5_128444_4 - EUKARYOTES_YBR070C	YBR070C	ALG14 - Component of UDP-GlcNAc transferase required for the second step of dolichyl-linked oligosaccharide synthesis; anchors the catalytic subunit Alg13p to the ER membrane; similar to bacterial and human glycosyltransferases	1	0	0	1	0.904761905	1	0.85	0.6875
1660_OG5_127671_4 - EUKARYOTES_YGR007W	YGR007W	"ECT1 - Ethanolamine-phosphate cytidylyltransferase, catalyzes the second step of phosphatidylethanolamine biosynthesis; involved in the maintenance of plasma membrane; similar to mammalian CTP: phosphocholine cytidylyl-transferases"	1	0.0625	0.194444444	1	0.952380952	1	0.8	0.75
1661_OG5_127068_4 - EUKARYOTES_YPL074W	YPL074W	"YTA6 - Putative ATPase of the CDC48/PAS1/SEC18 (AAA) family, localized to the cortex of mother cells but not to daughter cells"	1	0.1875	0	1	0.952380952	1	0.8	0.9375
1662_OG5_127068_4 - EUKARYOTES_YER047C	YER047C	"SAP1 - Putative ATPase of the AAA family, interacts with the Sin1p transcriptional repressor in the two-hybrid system"	1	0.1875	0	1	0.952380952	1	0.8	0.9375
1663_OG5_128804_4 - EUKARYOTES_YPL082C	YPL082C	"MOT1 - Essential abundant protein involved in regulation of transcription, removes Spt15p (TBP) from DNA via its C-terminal ATPase activity, forms a complex with TBP that binds TATA DNA with high affinity but with altered specificity"	1	0	0.055555556	1	0.80952381	0.928571429	1	0.3125
1664_OG5_129120_4 - EUKARYOTES_YOL080C	YOL080C	REX4 - Putative RNA exonuclease possibly involved in pre-rRNA processing and ribosome assembly	1	0	0.027777778	1	0.80952381	0.928571429	1	0.3125
1665_OG5_127729_4 - EUKARYOTES_YDL064W	YDL064W	UBC9 - SUMO-conjugating enzyme involved in the Smt3p conjugation pathway; nuclear protein required for S- and M-phase cyclin degradation and mitotic control; involved in proteolysis mediated by the anaphase-promoting complex cyclosome (APCC)	1	0	0	1	0.952380952	0.785714286	1	0.875
1666_OG5_127885_4 - EUKARYOTES_YGL047W	YGL047W	"ALG13 - Catalytic component of UDP-GlcNAc transferase, required for the second step of dolichyl-linked oligosaccharide synthesis; anchored to the ER membrane via interaction with Alg14p; similar to bacterial and human glycosyltransferases"	1	0	0	1	0.80952381	0.928571429	1	0.5
1667_OG5_128399_4 - EUKARYOTES_YLL031C	YLL031C	GPI13 - ER membrane localized phosphoryltransferase that adds phosphoethanolamine onto the third mannose residue of the glycosylphosphatidylinositol (GPI) anchor precursor; similar to human PIG-O protein	1	0	0	1	0.80952381	0.928571429	1	0.5625
1668_OG5_128467_4 - EUKARYOTES_YLL034C	YLL034C	"RIX7 - Putative ATPase of the AAA family, required for export of pre-ribosomal large subunits from the nucleus; distributed between the nucleolus, nucleoplasm, and nuclear periphery depending on growth conditions"	1	0	0	1	0.80952381	0.928571429	1	0.6875
1669_OG5_128530_4 - EUKARYOTES_YDR429C	YDR429C	"TIF35 - eIF3g subunit of the core complex of translation initiation factor 3 (eIF3), which is essential for translation; stimulates resumption of ribosomal scanning during translation reinitiation"	1	0	0	1	0.952380952	0.785714286	1	0.5625
1670_OG5_128586_4 - EUKARYOTES_YDL217C	YDL217C	TIM22 - Essential core component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; forms the channel through which proteins are imported	1	0	0	1	0.80952381	0.928571429	1	0.625
1671_OG5_128777_4 - EUKARYOTES_YLR336C	YLR336C	"SGD1 - Essential nuclear protein, required for biogenesis of the small ribosomal subunit; has a possible role in the osmoregulatory glycerol response; putative homolog of human NOM1 which is implicated in acute myeloid leukemia"	1	0	0	1	0.80952381	0.928571429	1	0.625
1672_OG5_129155_4 - EUKARYOTES_YDR397C	YDR397C	NCB2 - Subunit of a heterodimeric NC2 transcription regulator complex with Bur6p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2beta	1	0	0	1	0.80952381	0.928571429	1	0.25
1673_OG5_128168_4 - EUKARYOTES_YOR069W	YOR069W	VPS5 - Nexin-1 homolog required for localizing membrane proteins from a prevacuolar/late endosomal compartment back to the late Golgi apparatus; structural component of the retromer membrane coat complex; forms a retromer subcomplex with Vps17p	1	0	0	1	0.857142857	0.928571429	0.95	0.3125
1674_OG5_128931_4 - EUKARYOTES_YLR078C	YLR078C	"BOS1 - v-SNARE (vesicle specific SNAP receptor), localized to the endoplasmic reticulum membrane and necessary for vesicular transport from the ER to the Golgi"	1	0	0	1	0.857142857	0.928571429	0.95	0.3125
1675_OG5_127594_4 - EUKARYOTES_YBL021C	YBL021C	"HAP3 - Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences contributing to both complex assembly and DNA binding"	1	0	0	1	0.904761905	0.928571429	0.9	0.5625
1676_OG5_128212_4 - EUKARYOTES_YDR246W	YDR246W	TRS23 - One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic; human homolog is TRAPPC4	1	0	0	1	0.904761905	0.928571429	0.9	0.875
1677_OG5_127569_4 - EUKARYOTES_YPR035W	YPR035W	"GLN1 - Glutamine synthetase (GS), synthesizes glutamine from glutamate and ammonia; with Glt1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source and by amino acid limitation"	1	0	0.111111111	0.875	0.857142857	1	1	0.3125
1678_OG5_127681_4 - EUKARYOTES_YGR110W	YGR110W	CLD1 - Mitochondrial cardiolipin-specific phospholipase; functions upstream of Taz1p to generate monolyso-cardiolipin; transcription increases upon genotoxic stress; involved in restricting Ty1 transposition; has homology to mammalian CGI-58	1	0	0.027777778	0.875	0.857142857	1	1	0.3125
1679_OG5_127681_4 - EUKARYOTES_YLR099C	YLR099C	"ICT1 - Lysophosphatidic acid acyltransferase, responsible for enhanced phospholipid synthesis during organic solvent stress; null displays increased sensitivity to Calcofluor white; highly expressed during organic solvent stress"	1	0	0.027777778	0.875	0.857142857	1	1	0.3125
1680_OG5_126646_4 - EUKARYOTES_YDL019C	YDL019C	"OSH2 - Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability"	1	0	0	0.875	0.857142857	1	1	0.5
1681_OG5_126646_4 - EUKARYOTES_YHR073W	YHR073W	"OSH3 - Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability"	1	0	0	0.875	0.857142857	1	1	0.5
1682_OG5_126646_4 - EUKARYOTES_YAR042W	YAR042W	SWH1 - Protein similar to mammalian oxysterol-binding protein; contains ankyrin repeats; localizes to the Golgi and the nucleus-vacuole junction	1	0	0	0.875	0.857142857	1	1	0.5
1683_OG5_126948_4 - EUKARYOTES_YDR208W	YDR208W	"MSS4 - Phosphatidylinositol-4-phosphate 5-kinase, involved in actin cytoskeleton organization and cell morphogenesis; multicopy suppressor of stt4 mutation"	1	0	0	0.875	0.857142857	1	1	0.8125
1684_OG5_127144_4 - EUKARYOTES_YLR032W	YLR032W	RAD5 - DNA helicase proposed to promote replication fork regression during postreplication repair by template switching; RING finger containing ubiquitin ligase; stimulates the synthesis of free and PCNA-bound polyubiquitin chains by Ubc13p-Mms2p	1	0	0	0.875	0.857142857	1	1	0.4375
1685_OG5_127370_4 - EUKARYOTES_YJR119C	YJR119C	JHD2 - JmjC domain family histone demethylase specific for H3-K4 (histone H3 Lys4); removes methyl groups specifically added by Set1p methyltransferase; protein levels regulated by Not4p (E3 ubiquitin ligase) polyubiquitin-mediated degradation	1	0	0	0.875	0.857142857	1	1	0.375
1686_OG5_127425_4 - EUKARYOTES_YIL095W	YIL095W	PRK1 - Protein serine/threonine kinase; regulates the organization and function of the actin cytoskeleton and reduces endocytic ability of cell through the phosphorylation of the Pan1p-Sla1p-End3p protein complex	1	0	0	0.875	0.857142857	1	1	0.5625
1687_OG5_127425_4 - EUKARYOTES_YBR059C	YBR059C	"AKL1 - Ser-Thr protein kinase, member (with Ark1p and Prk1p) of the Ark kinase family; involved in endocytosis and actin cytoskeleton organization"	1	0	0	0.875	0.857142857	1	1	0.5625
1688_OG5_127425_4 - EUKARYOTES_YNL020C	YNL020C	ARK1 - Serine/threonine protein kinase involved in regulation of the cortical actin cytoskeleton; involved in control of endocytosis	1	0	0	0.875	0.857142857	1	1	0.5625
1689_OG5_127493_4 - EUKARYOTES_YMR207C	YMR207C	"HFA1 - Mitochondrial acetyl-coenzyme A carboxylase, catalyzes the production of malonyl-CoA in mitochondrial fatty acid biosynthesis"	1	0	0	0.875	0.857142857	1	1	0.5625
1690_OG5_127493_4 - EUKARYOTES_YNR016C	YNR016C	"ACC1 - Acetyl-CoA carboxylase, biotin containing enzyme that catalyzes the carboxylation of acetyl-CoA to form malonyl-CoA; required for de novo biosynthesis of long-chain fatty acids"	1	0	0	0.875	0.857142857	1	1	0.5625
1691_OG5_127910_4 - EUKARYOTES_YBL037W	YBL037W	"APL3 - Alpha-adaptin, large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport"	1	0	0	0.875	0.857142857	1	1	0.625
1692_OG5_128217_4 - EUKARYOTES_YNL325C	YNL325C	"FIG4 - Phosphatidylinositol 3,5-bisphosphate (PtdIns[3,5]P) phosphatase; required for efficient mating and response to osmotic shock; physically associates with and regulated by Vac14p; contains a SAC1-like domain"	1	0	0	0.875	0.857142857	1	1	0.5625
1693_OG5_128279_4 - EUKARYOTES_YOL052C	YOL052C	"SPE2 - S-adenosylmethionine decarboxylase, required for the biosynthesis of spermidine and spermine; cells lacking Spe2p require spermine or spermidine for growth in the presence of oxygen but not when grown anaerobically"	1	0	0	0.875	0.857142857	1	1	0.25
1694_OG5_128400_4 - EUKARYOTES_YMR135C	YMR135C	"GID8 - Protein of unknown function, involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; contains LisH and CTLH domains, like Vid30p; dosage-dependent regulator of START"	1	0	0	0.875	0.857142857	1	1	0.5625
1695_OG5_128479_4 - EUKARYOTES_YKL012W	YKL012W	"PRP40 - U1 snRNP protein involved in splicing, interacts with the branchpoint-binding protein during the formation of the second commitment complex"	1	0	0	0.875	0.857142857	1	1	0.625
1696_OG5_128499_4 - EUKARYOTES_YLR386W	YLR386W	"VAC14 - Protein involved in regulated synthesis of PtdIns(3,5)P(2), in control of trafficking of some proteins to the vacuole lumen via the MVB, and in maintenance of vacuole size and acidity; interacts with Fig4p; activator of Fab1p"	1	0	0	0.875	0.857142857	1	1	0.6875
1697_OG5_128561_4 - EUKARYOTES_YER162C	YER162C	"RAD4 - Protein that recognizes and binds damaged DNA (with Rad23p) during nucleotide excision repair; subunit of Nuclear Excision Repair Factor 2 (NEF2); also involved, with Rad23p, in turnover of ubiquitylated proteins"	1	0	0	0.875	0.857142857	1	1	0.5
1698_OG5_128617_4 - EUKARYOTES_YFR019W	YFR019W	"FAB1 - 1-phosphatidylinositol-3-phosphate 5-kinase; vacuolar membrane kinase that generates phosphatidylinositol (3,5)P2, which is involved in vacuolar sorting and homeostasis"	1	0	0	0.875	0.857142857	1	1	0.25
1699_OG5_128823_4 - EUKARYOTES_YLR015W	YLR015W	"BRE2 - Subunit of COMPASS (Set1C) complex, which methylates Lys4 of histone H3 and functions in silencing at telomeres; has a C-terminal Sdc1 Dpy-30 Interaction (SDI) domain that mediates binding to Sdc1p; similar to trithorax-group protein ASH2L"	1	0	0	0.875	0.857142857	1	1	0.4375
1700_OG5_128977_4 - EUKARYOTES_YGR028W	YGR028W	MSP1 - Mitochondrial protein involved in sorting of proteins in the mitochondria; putative membrane-spanning ATPase	1	0	0	0.875	0.857142857	1	1	0.25
1701_OG5_129397_4 - EUKARYOTES_YGR046W	YGR046W	TAM41 - Mitochondrial protein involved in protein import into the mitochondrial matrix; maintains the functional integrity of the TIM23 protein translocator complex; viability of null mutant is strain-dependent; mRNA is targeted to the bud	1	0	0	0.875	0.857142857	1	1	0.25
1702_OG5_129528_4 - EUKARYOTES_YNL139C	YNL139C	"THO2 - Subunit of the THO complex, which is required for efficient transcription elongation and involved in transcriptional elongation-associated recombination; required for LacZ RNA expression from certain plasmids"	1	0	0	0.875	0.857142857	1	1	0.1875
1703_OG5_129796_4 - EUKARYOTES_YBR251W	YBR251W	MRPS5 - Mitochondrial ribosomal protein of the small subunit	1	0	0	0.875	0.857142857	1	1	0.0625
1704_OG5_128486_4 - EUKARYOTES_YPL029W	YPL029W	"SUV3 - ATP-dependent RNA helicase, component of the mitochondrial degradosome along with the RNase Dss1p; the degradosome associates with the ribosome and mediates RNA turnover; also required during splicing of the COX1 AI5_beta intron"	1	0.0625	0.055555556	0.875	0.904761905	1	0.95	0.625
1705_OG5_127365_4 - EUKARYOTES_YJR048W	YJR048W	"CYC1 - Cytochrome c, isoform 1; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration"	1	0	0.166666667	0.875	0.904761905	1	0.95	0.75
1706_OG5_127365_4 - EUKARYOTES_YEL039C	YEL039C	"CYC7 - Cytochrome c isoform 2, expressed under hypoxic conditions; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration"	1	0	0.166666667	0.875	0.904761905	1	0.95	0.75
1707_OG5_127641_4 - EUKARYOTES_YLR008C	YLR008C	PAM18 - Constituent of the import motor (PAM complex) component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); essential J-protein cochaperone that stimulates Ssc1p ATPase activity to drive import; inhibited by Pam16p	1	0	0.083333333	0.875	0.904761905	1	0.95	0.875
1708_OG5_128632_4 - EUKARYOTES_YBR175W	YBR175W	"SWD3 - Essential subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member and ortholog of mammalian WDR5"	1	0	0.027777778	0.875	0.904761905	1	0.95	0.25
1709_OG5_127333_4 - EUKARYOTES_YPL037C	YPL037C	"EGD1 - Subunit beta1 of the nascent polypeptide-associated complex (NAC) involved in protein targeting, associated with cytoplasmic ribosomes; enhances DNA binding of the Gal4p activator; homolog of human BTF3b"	1	0	0	0.875	0.904761905	1	0.95	0.8125
1710_OG5_127451_4 - EUKARYOTES_YHR039C-A	YHR039C-A	"VMA10 - Subunit G of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; involved in vacuolar acidification"	1	0	0	0.875	0.904761905	1	0.95	0.8125
1711_OG5_128201_4 - EUKARYOTES_YKL018W	YKL018W	"SWD2 - Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lys 4 and is involved in telomeric silencing; subunit of CPF (cleavage and polyadenylation factor), a complex involved in RNAP II transcription termination"	1	0	0	0.875	0.904761905	1	0.95	0.6875
1712_OG5_128260_4 - EUKARYOTES_YGL063W	YGL063W	"PUS2 - Mitochondrial tRNA:pseudouridine synthase; acts at positions 27 and 28, but not at position 72; efficiently and rapidly targeted to mitochondria, specifically dedicated to mitochondrial tRNA modification"	1	0	0	0.875	0.904761905	1	0.95	0.8125
1713_OG5_128260_4 - EUKARYOTES_YPL212C	YPL212C	"PUS1 - tRNA:pseudouridine synthase, introduces pseudouridines at positions 26-28, 34-36, 65, and 67 of tRNA; nuclear protein that appears to be involved in tRNA export; also acts on U2 snRNA"	1	0	0	0.875	0.904761905	1	0.95	0.8125
1714_OG5_128282_4 - EUKARYOTES_YKR071C	YKR071C	DRE2 - Conserved component of an early step in the cytosolic Fe-S protein assembly (CIA) machinery; contains an Fe-S cluster that receives electrons from NADPH via the action of Tah18p; ortholog of human Ciapin1	1	0	0	0.875	0.904761905	1	0.95	0.875
1715_OG5_129600_4 - EUKARYOTES_YGR200C	YGR200C	"ELP2 - Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; target of Kluyveromyces lactis zymocin"	1	0	0	0.875	0.904761905	1	0.95	0.25
1716_OG5_127145_4 - EUKARYOTES_YKL085W	YKL085W	"MDH1 - Mitochondrial malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the tricarboxylic acid (TCA) cycle; phosphorylated"	1	0	0.166666667	1	0.714285714	1	1	0.3125
1717_OG5_127570_4 - EUKARYOTES_YNR001C	YNR001C	"CIT1 - Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate; the rate-limiting enzyme of the TCA cycle; nuclear encoded mitochondrial protein"	1	0	0.055555556	1	0.857142857	0.857142857	1	0.625
1718_OG5_127570_4 - EUKARYOTES_YCR005C	YCR005C	"CIT2 - Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors"	1	0	0.055555556	1	0.857142857	0.857142857	1	0.625
1719_OG5_127570_4 - EUKARYOTES_YPR001W	YPR001W	CIT3 - Dual specificity mitochondrial citrate and methylcitrate synthase; catalyzes the condensation of acetyl-CoA and oxaloacetate to form citrate and that of propionyl-CoA and oxaloacetate to form 2-methylcitrate	1	0	0.055555556	1	0.857142857	0.857142857	1	0.625
1720_OG5_127358_4 - EUKARYOTES_YLR251W	YLR251W	SYM1 - Protein required for ethanol metabolism; induced by heat shock and localized to the inner mitochondrial membrane; homologous to mammalian peroxisomal membrane protein Mpv17	1	0	0	1	0.857142857	0.857142857	1	0.125
1721_OG5_127535_4 - EUKARYOTES_YPR037C	YPR037C	"ERV2 - Flavin-linked sulfhydryl oxidase localized to the endoplasmic reticulum lumen, involved in disulfide bond formation within the ER"	1	0	0	1	0.857142857	0.857142857	1	0.6875
1722_OG5_127535_4 - EUKARYOTES_YGR029W	YGR029W	"ERV1 - Flavin-linked sulfhydryl oxidase of the mitochondrial intermembrane space (IMS), oxidizes Mia40p as part of a disulfide relay system that promotes IMS retention of imported proteins; ortholog of human hepatopoietin (ALR)"	1	0	0	1	0.857142857	0.857142857	1	0.6875
1723_OG5_128080_4 - EUKARYOTES_YOL013C	YOL013C	HRD1 - Ubiquitin-protein ligase required for endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins; genetically linked to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring finger	1	0	0	1	0.857142857	0.857142857	1	0.9375
1724_OG5_128179_4 - EUKARYOTES_YOR112W	YOR112W	"CEX1 - Cytoplasmic component of the nuclear aminoacylation-dependent tRNA export pathway; interacts with nuclear pore component Nup116p; copurifies with tRNA export receptors Los1p and Msn5p, as well as eIF-1a and the RAN GTPase Gsp1p"	1	0	0	1	0.857142857	0.857142857	1	0.8125
1725_OG5_128290_4 - EUKARYOTES_YIL129C	YIL129C	"TAO3 - Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with protein kinase Cbk1p and also with Kic1p"	1	0	0	1	0.714285714	1	1	0.0625
1726_OG5_128319_4 - EUKARYOTES_YMR138W	YMR138W	"CIN4 - GTP-binding protein involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl; regulated by the GTPase-activating protein, Cin2p, the human retinitis pigmentosa 2 (RP2) homolog"	1	0	0	1	0.857142857	0.857142857	1	0.875
1727_OG5_128340_4 - EUKARYOTES_YKR024C	YKR024C	DBP7 - Putative ATP-dependent RNA helicase of the DEAD-box family involved in ribosomal biogenesis; essential for growth under anaerobic conditions	1	0	0	1	0.714285714	1	1	0.875
1728_OG5_128360_4 - EUKARYOTES_YDR416W	YDR416W	"SYF1 - Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; null mutant has splicing defect and arrests in G2/M; homologs in human and C. elegans"	1	0	0	1	0.857142857	0.857142857	1	0.8125
1729_OG5_128573_4 - EUKARYOTES_YFR021W	YFR021W	"ATG18 - Phosphoinositide binding protein required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein"	1	0	0	1	0.714285714	1	1	0.25
1730_OG5_128732_4 - EUKARYOTES_YBR228W	YBR228W	"SLX1 - Subunit of a complex, with Slx4p, that hydrolyzes 5' branches from duplex DNA in response to stalled or converging replication forks; function overlaps with that of Sgs1p-Top3p"	1	0	0	1	0.714285714	1	1	0.4375
1731_OG5_126929_4 - EUKARYOTES_YDR371W	YDR371W	"CTS2 - Putative chitinase, functionally complements A. gossypii cts2 mutant sporulation defect"	1	0.0625	0.194444444	1	0.761904762	1	0.95	0.125
1732_OG5_127248_4 - EUKARYOTES_YDL087C	YDL087C	LUC7 - Essential protein associated with the U1 snRNP complex; splicing factor involved in recognition of 5' splice site; contains two zinc finger motifs; N-terminal zinc finger binds pre-mRNA	1	0	0	1	0.761904762	1	0.95	0.6875
1733_OG5_127426_4 - EUKARYOTES_YGR058W	YGR058W	"PEF1 - Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2"	1	0	0	1	0.761904762	1	0.95	0.25
1734_OG5_127880_4 - EUKARYOTES_YER129W	YER129W	"SAK1 - Upstream serine/threonine kinase for the SNF1 complex; partially redundant with Elm1p and Tos3p; members of this family have functional orthology with LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome"	1	0	0	1	0.761904762	1	0.95	0.125
1735_OG5_127880_4 - EUKARYOTES_YGL179C	YGL179C	"TOS3 - Protein kinase, related to and functionally redundant with Elm1p and Sak1p for the phosphorylation and activation of Snf1p; functionally orthologous to LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome"	1	0	0	1	0.761904762	1	0.95	0.125
1736_OG5_128288_4 - EUKARYOTES_YCL037C	YCL037C	"SRO9 - Cytoplasmic RNA-binding protein that associates with translating ribosomes; involved in heme regulation of Hap1p as a component of the HMC complex, also involved in the organization of actin filaments; contains a La motif"	1	0	0	1	0.761904762	1	0.95	0.1875
1737_OG5_128390_4 - EUKARYOTES_YLR268W	YLR268W	"SEC22 - R-SNARE protein; assembles into SNARE complex with Bet1p, Bos1p and Sed5p; cycles between the ER and Golgi complex; involved in anterograde and retrograde transport between the ER and Golgi; synaptobrevin homolog"	1	0	0	1	0.904761905	0.857142857	0.95	0.8125
1738_OG5_128581_4 - EUKARYOTES_YJR058C	YJR058C	"APS2 - Small subunit of the clathrin-associated adaptor complex AP-2, which is involved in protein sorting at the plasma membrane; related to the sigma subunit of the mammalian plasma membrane clathrin-associated protein (AP-2) complex"	1	0	0	1	0.904761905	0.857142857	0.95	0.75
1739_OG5_129146_4 - EUKARYOTES_YKL021C	YKL021C	"MAK11 - Protein involved in an early, nucleolar step of 60S ribosomal subunit biogenesis; essential for cell growth and replication of killer M1 dsRNA virus; contains four beta-transducin repeats"	1	0	0	1	0.761904762	1	0.95	0.625
1740_OG5_129233_4 - EUKARYOTES_YBR020W	YBR020W	"GAL1 - Galactokinase, phosphorylates alpha-D-galactose to alpha-D-galactose-1-phosphate in the first step of galactose catabolism; expression regulated by Gal4p"	1	0.0625	0	1	0.80952381	1	0.9	0.3125
1741_OG5_129233_4 - EUKARYOTES_YDR009W	YDR009W	GAL3 - Transcriptional regulator involved in activation of the GAL genes in response to galactose; forms a complex with Gal80p to relieve Gal80p inhibition of Gal4p; binds galactose and ATP but does not have galactokinase activity	1	0.0625	0	1	0.80952381	1	0.9	0.3125
1742_OG5_127731_4 - EUKARYOTES_YJR132W	YJR132W	"NMD5 - Karyopherin, a carrier protein involved in nuclear import of proteins; importin beta homolog"	1	0	0	1	0.80952381	1	0.9	0.8125
1743_OG5_128760_4 - EUKARYOTES_YJL124C	YJL124C	"LSM1 - Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAs"	1	0	0	1	0.80952381	1	0.9	0.6875
1744_OG5_129392_4 - EUKARYOTES_YMR259C	YMR259C	YMR259C - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR259C is not an essential gene	1	0	0	1	0.80952381	1	0.9	0.0625
1745_OG5_129561_4 - EUKARYOTES_YKR062W	YKR062W	"TFA2 - TFIIE small subunit, involved in RNA polymerase II transcription initiation"	1	0	0	1	0.80952381	1	0.9	0.25
1746_OG5_129623_4 - EUKARYOTES_YPL096W	YPL096W	PNG1 - Conserved peptide N-glycanase required for deglycosylation of misfolded glycoproteins during proteasome-dependent degradation; localizes to the cytoplasm and nucleus; activity is enhanced by interaction with Rad23p	1	0	0	1	0.80952381	1	0.9	0.1875
1747_OG5_127081_4 - EUKARYOTES_YJR005W	YJR005W	"APL1 - Beta-adaptin, large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport; similar to mammalian beta-chain of the clathrin associated protein complex"	1	0	0	0.875	0.904761905	0.928571429	1	0.875
1748_OG5_127081_4 - EUKARYOTES_YKL135C	YKL135C	"APL2 - Beta-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting"	1	0	0	0.875	0.904761905	0.928571429	1	0.875
1749_OG5_127525_4 - EUKARYOTES_YJL176C	YJL176C	"SWI3 - Subunit of the SWI/SNF chromatin remodeling complex, which regulates transcription by remodeling chromosomes; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2"	1	0	0	0.875	0.904761905	0.928571429	1	0.5625
1750_OG5_127525_4 - EUKARYOTES_YFR037C	YFR037C	"RSC8 - Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters"	1	0	0	0.875	0.904761905	0.928571429	1	0.5625
1751_OG5_127738_4 - EUKARYOTES_YLR142W	YLR142W	"PUT1 - Proline oxidase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; PUT1 transcription is induced by Put3p in the presence of proline and the absence of a preferred nitrogen source"	1	0	0	0.875	0.904761905	0.928571429	1	0.4375
1752_OG5_128188_4 - EUKARYOTES_YOR262W	YOR262W	YOR262W - Protein of unknown function required for establishment of sister chromatid cohesion; contains an ATP/GTP binding site motif; similar to YLR243W and is highly conserved across species and homologous to human gene GPN2/ATPBD1B	1	0	0	0.875	0.904761905	0.928571429	1	0.875
1753_OG5_128229_4 - EUKARYOTES_YJL033W	YJL033W	HCA4 - Putative nucleolar DEAD box RNA helicase; high-copy number suppression of a U14 snoRNA processing mutant suggests an involvement in 18S rRNA synthesis	1	0	0	0.875	0.904761905	0.928571429	1	0.8125
1754_OG5_128332_4 - EUKARYOTES_YNL227C	YNL227C	"JJJ1 - Co-chaperone that stimulates the ATPase activity of Ssa1p, required for a late step of ribosome biogenesis; associated with the cytosolic large ribosomal subunit; contains a J-domain; mutation causes defects in fluid-phase endocytosis"	1	0	0	0.875	0.904761905	0.928571429	1	0.6875
1755_OG5_128354_4 - EUKARYOTES_YOL041C	YOL041C	NOP12 - Nucleolar protein involved in pre-25S rRNA processing and biogenesis of large 60S ribosomal subunit; contains an RNA recognition motif (RRM); binds to Ebp2; similar to Nop13p and Nsr1p	1	0	0	0.875	0.904761905	0.928571429	1	0.75
1756_OG5_128859_4 - EUKARYOTES_YPR180W	YPR180W	"AOS1 - Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability"	1	0	0	0.875	0.904761905	0.928571429	1	0.4375
1757_OG5_128950_4 - EUKARYOTES_YCL008C	YCL008C	"STP22 - Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; homologous to the mouse and human Tsg101 tumor susceptibility gene; mutants exhibit a Class E Vps phenotype"	1	0	0	0.875	0.904761905	0.928571429	1	0.125
1758_OG5_127823_4 - EUKARYOTES_YOR163W	YOR163W	DDP1 - Polyphosphate phosphatase; hydrolyzes diphosphorylated inositol polyphosphates and diadenosine polyphosphates; has high specificity for diadenosine hexa- and pentaphosphates; member of the MutT family of nucleotide hydrolases	1	0.0625	0.055555556	1	0.857142857	1	0.85	0.0625
1759_OG5_128515_4 - EUKARYOTES_YMR069W	YMR069W	"NAT4 - N alpha-acetyl-transferase, involved in acetylation of the N-terminal residues of histones H4 and H2A"	1	0	0	1	0.857142857	1	0.85	0.625
1760_OG5_128547_4 - EUKARYOTES_YPR147C	YPR147C	YPR147C - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS	1	0	0	1	0.857142857	1	0.85	0.25
1761_OG5_129157_4 - EUKARYOTES_YPL064C	YPL064C	"CWC27 - Component of a complex containing Cef1p, putatively involved in pre-mRNA splicing; has similarity to S. pombe Cwf27p"	1	0	0	1	0.857142857	1	0.85	0.5
1762_OG5_129530_4 - EUKARYOTES_YJL179W	YJL179W	"PFD1 - Subunit of heterohexameric prefoldin, which binds cytosolic chaperonin and transfers target proteins to it; involved in the biogenesis of actin and of alpha- and gamma-tubulin"	1	0	0	1	0.857142857	1	0.85	0.0625
1763_OG5_127053_4 - EUKARYOTES_YDR510W	YDR510W	"SMT3 - Ubiquitin-like protein of the SUMO family, conjugated to lysine residues of target proteins; regulates chromatid cohesion, chromosome segregation, APC-mediated proteolysis, DNA replication and septin ring dynamics; phosphorylated at Ser2"	1	0	0	0.875	0.952380952	0.928571429	0.95	1
1764_OG5_127770_4 - EUKARYOTES_YNL138W	YNL138W	"SRV2 - CAP (cyclase-associated protein) subunit of adenylyl cyclase complex; N-terminus binds adenylyl cyclase and facilitates activation by RAS; C-terminus binds ADP-actin monomers, facilitating regulation of actin dynamics and cell morphogenesis"	1	0	0	0.875	0.952380952	0.928571429	0.95	0.75
1765_OG5_127814_4 - EUKARYOTES_YGR074W	YGR074W	"SMD1 - Core Sm protein Sm D1; part of heteroheptameric complex (with Smb1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D1"	1	0	0	0.875	0.952380952	0.928571429	0.95	0.9375
1766_OG5_128056_4 - EUKARYOTES_YKL145W	YKL145W	RPT1 - One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for optimal CDC20 transcription; interacts with Rpn12p and Ubr1p; mutant has aneuploidy tolerance	1	0	0	0.875	0.952380952	0.928571429	0.95	1
1767_OG5_126635_4 - EUKARYOTES_YMR104C	YMR104C	YPK2 - Protein kinase with similarity to serine/threonine protein kinase Ypk1p; functionally redundant with YPK1 at the genetic level; participates in a signaling pathway required for optimal cell wall integrity; homolog of mammalian kinase SGK	1	0	0	0.75	0.952380952	1	1	0.5625
1768_OG5_126635_4 - EUKARYOTES_YKL126W	YKL126W	YPK1 - Serine/threonine protein kinase that phosphorylates and downregulates flippase activator Fpk1p; mutations affect receptor-mediated endocytosis and sphingolipid-mediated and cell integrity signaling pathways; homolog of mammalian kinase SGK	1	0	0	0.75	0.952380952	1	1	0.5625
1769_OG5_129384_4 - EUKARYOTES_YPL001W	YPL001W	"HAT1 - Catalytic subunit of the Hat1p-Hat2p histone acetyltransferase complex that uses the cofactor acetyl coenzyme A, to acetylate free nuclear and cytoplasmic histone H4; involved in telomeric silencing and DNA double-strand break repair"	1	0	0	0.75	0.952380952	1	1	0.125
1770_OG5_127877_4 - EUKARYOTES_YBR001C	YBR001C	"NTH2 - Putative neutral trehalase, required for thermotolerance and may mediate resistance to other cellular stresses"	1	0	0.194444444	1	0.761904762	0.928571429	1	0.1875
1771_OG5_127877_4 - EUKARYOTES_YDR001C	YDR001C	"NTH1 - Neutral trehalase, degrades trehalose; required for thermotolerance and may mediate resistance to other cellular stresses; may be phosphorylated by Cdc28p"	1	0	0.194444444	1	0.761904762	0.928571429	1	0.1875
1772_OG5_128406_4 - EUKARYOTES_YDR376W	YDR376W	"ARH1 - Oxidoreductase of the mitochondrial inner membrane, involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viability"	1	0	0.083333333	1	0.761904762	0.928571429	1	0.6875
1773_OG5_128661_4 - EUKARYOTES_YDR204W	YDR204W	"COQ4 - Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex"	1	0	0	1	0.761904762	0.928571429	1	0.5625
1774_OG5_128925_4 - EUKARYOTES_YHR081W	YHR081W	"LRP1 - Nuclear exosome-associated nucleic acid binding protein; involved in RNA processing, surveillance, degradation, tethering, and export; homolog of mammalian nuclear matrix protein C1D involved in regulation of DNA repair and recombination"	1	0	0	1	0.761904762	0.928571429	1	0.4375
1775_OG5_129000_4 - EUKARYOTES_YFL044C	YFL044C	OTU1 - Deubiquitylation enzyme that binds to the chaperone-ATPase Cdc48p; may contribute to regulation of protein degradation by deubiquitylating substrates that have been ubiquitylated by Ufd2p; member of the Ovarian Tumor (OTU) family	1	0	0	1	0.761904762	0.928571429	1	0.5
1776_OG5_129027_4 - EUKARYOTES_YBR060C	YBR060C	"ORC2 - Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; interacts with Spp1p and with trimethylated histone H3; phosphorylated by Cdc28p"	1	0	0	1	0.761904762	0.928571429	1	0.625
1777_OG5_127813_4 - EUKARYOTES_YDL226C	YDL226C	"GCS1 - ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Glo3p"	1	0	0	1	0.904761905	0.785714286	1	0.75
1778_OG5_128126_4 - EUKARYOTES_YDR083W	YDR083W	"RRP8 - Nucleolar protein involved in rRNA processing, pre-rRNA cleavage at site A2; also involved in telomere maintenance; mutation is synthetically lethal with a gar1 mutation"	1	0	0	1	0.904761905	0.785714286	1	0.9375
1779_OG5_128401_4 - EUKARYOTES_YLR116W	YLR116W	"MSL5 - Component of the commitment complex, which defines the first step in the splicing pathway; essential protein that interacts with Mud2p and Prp40p, forming a bridge between the intron ends; also involved in nuclear retention of pre-mRNA"	1	0	0	1	0.904761905	0.785714286	1	0.6875
1780_OG5_128419_4 - EUKARYOTES_YJR014W	YJR014W	"TMA22 - Protein of unknown function; associates with ribosomes and has a putative RNA binding domain; interacts with Tma20p; similar to human GRAP and human DRP1, which interacts with human Tma20p homolog MCT-1"	1	0	0	1	0.904761905	0.785714286	1	0.8125
1781_OG5_128481_4 - EUKARYOTES_YIL110W	YIL110W	HPM1 - AdoMet-dependent methyltransferase involved in a novel 3-methylhistidine modification of ribosomal protein Rpl3p; seven beta-strand MTase family member; null mutant exhibits a weak vacuolar protein sorting defect and caspofungin resistance	1	0	0	1	0.904761905	0.785714286	1	0.6875
1782_OG5_128840_4 - EUKARYOTES_YOR308C	YOR308C	SNU66 - Component of the U4/U6.U5 snRNP complex involved in pre-mRNA splicing via spliceosome; also required for pre-5S rRNA processing and may act in concert with Rnh70p; has homology to human SART-1	1	0	0	1	0.904761905	0.785714286	1	0.5
1783_OG5_127378_4 - EUKARYOTES_YAL022C	YAL022C	"FUN26 - Vacuolar membrane transporter with broad nucleoside selectivity; may regulate balance of nicotinamide riboside (NmR) levels between cytosol and vacuole, contributing to salvage of NmR for use in cytosolic NAD+ synthesis"	1	0	0	1	0.80952381	0.928571429	0.95	0.3125
1784_OG5_127448_4 - EUKARYOTES_YLR325C	YLR325C	"RPL38 - Protein component of the large (60S) ribosomal subunit, has similarity to rat L38 ribosomal protein"	1	0	0	1	0.952380952	0.785714286	0.95	0.8125
1785_OG5_127916_4 - EUKARYOTES_YOL012C	YOL012C	"HTZ1 - Histone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin"	1	0	0	1	0.80952381	0.928571429	0.95	0.75
1786_OG5_127982_4 - EUKARYOTES_YIR026C	YIR026C	"YVH1 - Protein phosphatase involved in vegetative growth at low temperatures, sporulation, and glycogen accumulation; mutants are defective in 60S ribosome assembly; member of the dual-specificity family of protein phosphatases"	1	0	0	1	0.952380952	0.785714286	0.95	0.875
1787_OG5_128540_4 - EUKARYOTES_YMR080C	YMR080C	NAM7 - ATP-dependent RNA helicase of the SFI superfamily involved in nonsense mediated mRNA decay; required for efficient translation termination at nonsense codons and targeting of NMD substrates to P-bodies; involved in telomere maintenance	1	0	0	1	0.80952381	0.928571429	0.95	0.625
1788_OG5_128643_4 - EUKARYOTES_YDR005C	YDR005C	MAF1 - Negative regulator of RNA polymerase III; component of several signaling pathways that repress polymerase III transcription in response to changes in cellular environment; targets the initiation factor TFIIIB	1	0	0	1	0.80952381	0.928571429	0.95	0.5
1789_OG5_129090_4 - EUKARYOTES_YML015C	YML015C	"TAF11 - TFIID subunit (40 kDa), involved in RNA polymerase II transcription initiation, similar to histone H3 with atypical histone fold motif of Spt3-like transcription factors"	1	0	0	1	0.80952381	0.928571429	0.95	0.3125
1790_OG5_129317_4 - EUKARYOTES_YHR062C	YHR062C	"RPP1 - Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs"	1	0	0	1	0.80952381	0.928571429	0.95	0.3125
1791_OG5_129748_4 - EUKARYOTES_YOL032W	YOL032W	"OPI10 - Protein with a possible role in phospholipid biosynthesis, based on inositol-excreting phenotype of the null mutant and its suppression by exogenous choline"	1	0	0	1	0.80952381	0.928571429	0.95	0.25
1792_OG5_129820_4 - EUKARYOTES_YPL051W	YPL051W	ARL3 - GTPase of the Ras superfamily required to recruit Arl1p to the Golgi; similar to ADP-ribosylation factor	1	0	0	1	0.80952381	0.928571429	0.95	0.125
1793_OG5_129268_4 - EUKARYOTES_YPR140W	YPR140W	"TAZ1 - Lyso-phosphatidylcholine acyltransferase, required for normal phospholipid content of mitochondrial membranes; may remodel acyl groups of cardiolipin in the inner membrane; human ortholog tafazzin is implicated in Barth syndrome"	1	0	0.027777778	1	0.857142857	0.928571429	0.9	0.125
1794_OG5_127307_4 - EUKARYOTES_YGL205W	YGL205W	"POX1 - Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix"	1	0	0	1	0.857142857	0.928571429	0.9	0.1875
1795_OG5_128069_4 - EUKARYOTES_YDL074C	YDL074C	"BRE1 - E3 ubiquitin ligase, forms heterodimer with Rad6p to monoubiquinate histone H2B-K123, which is required for the subsequent methylation of histone H3-K4 and H3-K79; required for DSBR, transcription, silencing, and checkpoint control"	1	0	0	1	0.857142857	0.928571429	0.9	0.6875
1796_OG5_128174_4 - EUKARYOTES_YBR133C	YBR133C	"HSL7 - Protein arginine N-methyltransferase that exhibits septin and Hsl1p-dependent bud neck localization and periodic Hsl1p-dependent phosphorylation; required along with Hsl1p for bud neck recruitment, phosphorylation, and degradation of Swe1p"	1	0	0	1	0.857142857	0.928571429	0.9	0.8125
1797_OG5_127371_4 - EUKARYOTES_YDR282C	YDR282C	YDR282C - Putative protein of unknown function	1	0.0625	0.138888889	0.875	0.80952381	1	1	0.6875
1798_OG5_127371_4 - EUKARYOTES_YDL001W	YDL001W	RMD1 - Cytoplasmic protein required for sporulation	1	0.0625	0.138888889	0.875	0.80952381	1	1	0.6875
1799_OG5_128111_4 - EUKARYOTES_YKL002W	YKL002W	"DID4 - Class E Vps protein of the ESCRT-III complex, required for sorting of integral membrane proteins into lumenal vesicles of multivesicular bodies, and for delivery of newly synthesized vacuolar enzymes to the vacuole, involved in endocytosis"	1	0.0625	0	0.875	0.952380952	0.857142857	1	0.875
1800_OG5_128863_4 - EUKARYOTES_YKL143W	YKL143W	"LTV1 - Component of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; required for ribosomal small subunit export from nucleus; required for growth at low temperature"	1	0.0625	0	0.875	0.80952381	1	1	0.5625
1801_OG5_127277_4 - EUKARYOTES_YHR102W	YHR102W	"KIC1 - Protein kinase of the PAK/Ste20 kinase family, required for cell integrity possibly through regulating 1,6-beta-glucan levels in the wall; physically interacts with Cdc31p (centrin), which is a component of the spindle pole body"	1	0	0	0.875	0.80952381	1	1	0.25
1802_OG5_127277_4 - EUKARYOTES_YDR523C	YDR523C	"SPS1 - Putative protein serine/threonine kinase expressed at the end of meiosis and localized to the prospore membrane, required for correct localization of enzymes involved in spore wall synthesis"	1	0	0	0.875	0.80952381	1	1	0.25
1803_OG5_127416_4 - EUKARYOTES_YOL115W	YOL115W	"PAP2 - Non-canonical poly(A) polymerase, involved in nuclear RNA degradation as a component of the TRAMP complex; catalyzes polyadenylation of hypomodified tRNAs, and snoRNA and rRNA precursors; overlapping but non-redundant functions with Trf5p"	1	0	0	0.875	0.80952381	1	1	1
1804_OG5_127416_4 - EUKARYOTES_YNL299W	YNL299W	"TRF5 - Non-canonical poly(A) polymerase, involved in nuclear RNA degradation as a component of the TRAMP complex; catalyzes polyadenylation of hypomodified tRNAs, and snoRNA and rRNA precursors; overlapping but non-redundant functions with Pap2p"	1	0	0	0.875	0.80952381	1	1	1
1805_OG5_127489_4 - EUKARYOTES_YNL083W	YNL083W	"SAL1 - ADP/ATP transporter; member of the Ca2+-binding subfamily of mitochondrial carriers, with two EF-hand motifs; transport activity of either Sal1p or Pet9p is critical for viability; polymorphic in different S. cerevisiae strains"	1	0	0	0.875	0.80952381	1	1	0.375
1806_OG5_127559_4 - EUKARYOTES_YJL106W	YJL106W	"IME2 - Serine/threonine protein kinase involved in activation of meiosis, associates with Ime1p and mediates its stability, activates Ndt80p; IME2 expression is positively regulated by Ime1p"	1	0	0	0.875	0.80952381	1	1	0.4375
1807_OG5_127970_4 - EUKARYOTES_YMR309C	YMR309C	"NIP1 - eIF3c subunit of the eukaryotic translation initiation factor 3 (eIF3), involved in the assembly of preinitiation complex and start codon selection"	1	0	0	0.875	0.952380952	0.857142857	1	0.75
1808_OG5_128098_4 - EUKARYOTES_YOL142W	YOL142W	RRP40 - Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain both S1 and KH RNA binding domains; has similarity to human hRrp40p (EXOSC3)	1	0	0	0.875	0.80952381	1	1	0.875
1809_OG5_128269_4 - EUKARYOTES_YJR065C	YJR065C	"ARP3 - Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity"	1	0	0	0.875	0.80952381	1	1	0.375
1810_OG5_128373_4 - EUKARYOTES_YDR266C	YDR266C	"YDR266C - Protein of unknown function that may interact with ribosomes, based on co-purification experiments;green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; contains a RING finger domain"	1	0	0	0.875	0.952380952	0.857142857	1	0.5625
1811_OG5_128403_4 - EUKARYOTES_YOR056C	YOR056C	NOB1 - Essential nuclear protein involved in proteasome maturation and synthesis of 40S ribosomal subunits; required for cleavage of the 20S pre-rRNA to generate the mature 18S rRNA	1	0	0	0.875	0.952380952	0.857142857	1	0.8125
1812_OG5_128487_4 - EUKARYOTES_YDR152W	YDR152W	GIR2 - Highly-acidic cytoplasmic RWD domain-containing protein of unknown function; forms a complex with Rbg2p; interacts with Rbg1p and Gcn1p; associates with translating ribosomes; putative intrinsically unstructured protein	1	0	0	0.875	0.952380952	0.857142857	1	0.625
1813_OG5_128628_4 - EUKARYOTES_YOR346W	YOR346W	"REV1 - Deoxycytidyl transferase, forms a complex with the subunits of DNA polymerase zeta, Rev3p and Rev7p; involved in repair of abasic sites in damaged DNA"	1	0	0	0.875	0.80952381	1	1	0.5
1814_OG5_129436_4 - EUKARYOTES_YDR180W	YDR180W	"SCC2 - Subunit of cohesin loading factor (Scc2p-Scc4p), a complex required for loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during DSB repair via histone H2AX; evolutionarily-conserved adherin"	1	0	0	0.875	0.80952381	1	1	0.125
1815_OG5_129639_4 - EUKARYOTES_YNL041C	YNL041C	"COG6 - Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments"	1	0	0	0.875	0.80952381	1	1	0.1875
1816_OG5_129727_4 - EUKARYOTES_YDR165W	YDR165W	TRM82 - Subunit of a tRNA methyltransferase complex composed of Trm8p and Trm82p that catalyzes 7-methylguanosine modification of tRNA	1	0	0	0.875	0.80952381	1	1	0.1875
1817_OG5_129896_4 - EUKARYOTES_YBL004W	YBL004W	"UTP20 - Component of the small-subunit (SSU) processome, which is involved in the biogenesis of the 18S rRNA"	1	0	0	0.875	0.80952381	1	1	0.125
1818_OG5_127778_4 - EUKARYOTES_YGL119W	YGL119W	"COQ8 - Protein required for ubiquinone (coenzyme Q) biosynthesis and for respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis"	1	0	0.055555556	0.875	0.857142857	1	0.95	0.75
1819_OG5_127792_4 - EUKARYOTES_YNL250W	YNL250W	"RAD50 - Subunit of MRX complex, with Mre11p and Xrs2p, involved in processing double-strand DNA breaks in vegetative cells, initiation of meiotic DSBs, telomere maintenance, and nonhomologous end joining"	1	0	0	0.875	0.857142857	1	0.95	0.9375
1820_OG5_128206_4 - EUKARYOTES_YPL006W	YPL006W	"NCR1 - Vacuolar membrane protein that transits through the biosynthetic vacuolar protein sorting pathway, involved in sphingolipid metabolism; glycoprotein and functional orthologue of human Niemann Pick C1 (NPC1) protein"	1	0	0	0.875	0.857142857	1	0.95	0.125
1821_OG5_129527_4 - EUKARYOTES_YDR027C	YDR027C	"VPS54 - Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; potentially phosphorylated by Cdc28p"	1	0	0	0.875	0.857142857	1	0.95	0.125
1822_OG5_127697_4 - EUKARYOTES_YDR264C	YDR264C	AKR1 - Palmitoyl transferase involved in protein palmitoylation; acts as a negative regulator of pheromone response pathway; required for endocytosis of pheromone receptors; involved in cell shape control; contains ankyrin repeats	1	0	0	0.875	0.904761905	1	0.9	0.25
1823_OG5_127697_4 - EUKARYOTES_YOR034C	YOR034C	AKR2 - Ankyrin repeat-containing protein similar to Akr1p; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; possibly involved in constitutive endocytosis of Ste3p	1	0	0	0.875	0.904761905	1	0.9	0.25
1824_OG5_128483_4 - EUKARYOTES_YKL207W	YKL207W	AIM27 - Member of a transmembrane complex required for efficient folding of proteins in the ER; required for respiratory growth; null mutant displays induction of the unfolded protein response	1	0	0	0.875	0.904761905	1	0.9	0.5625
1825_OG5_128952_4 - EUKARYOTES_YKR030W	YKR030W	"GMH1 - Golgi membrane protein of unknown function, interacts with Gea1p and Gea2p; required for localization of Gea2p; computational analysis suggests a possible role in either cell wall synthesis or protein-vacuolar targeting"	1	0	0	0.875	0.904761905	1	0.9	0.4375
1826_OG5_128374_4 - EUKARYOTES_YKL100C	YKL100C	YKL100C - Putative protein of unknown function with similarity to a human minor histocompatibility antigen and signal peptide peptidases; YKL100C is not an essential gene	1	0	0	0.875	0.952380952	1	0.85	0.625
1827_OG5_128774_4 - EUKARYOTES_YNL312W	YNL312W	"RFA2 - Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination"	1	0.0625	0	1	0.666666667	1	1	0.5
1828_OG5_127854_4 - EUKARYOTES_YHR200W	YHR200W	RPN10 - Non-ATPase base subunit of the 19S regulatory particle (RP) of the 26S proteasome; N-terminus plays a role in maintaining the structural integrity of the RP; binds selectively to polyubiquitin chains; homolog of the mammalian S5a protein	1	0	0	1	0.952380952	0.714285714	1	0.9375
1829_OG5_128488_4 - EUKARYOTES_YNL280C	YNL280C	"ERG24 - C-14 sterol reductase, acts in ergosterol biosynthesis; mutants accumulate the abnormal sterol ignosterol (ergosta-8,14 dienol), and are viable under anaerobic growth conditions but inviable on rich medium under aerobic conditions"	1	0	0	1	0.666666667	1	1	0.1875
1830_OG5_128801_4 - EUKARYOTES_YNR015W	YNR015W	"SMM1 - Dihydrouridine synthase, member of a family of dihydrouridine synthases including Dus1p, Smm1p, Dus3p, and Dus4p; modifies uridine residues at position 20 of cytoplasmic tRNAs"	1	0	0	1	0.80952381	0.857142857	1	0.5
1831_OG5_129445_4 - EUKARYOTES_YMR125W	YMR125W	"STO1 - Large subunit of the nuclear mRNA cap-binding protein complex, interacts with Npl3p to carry nuclear poly(A)+ mRNA to cytoplasm; also involved in nuclear mRNA degradation and telomere maintenance; orthologous to mammalian CBP80"	1	0	0	1	0.80952381	0.857142857	1	0.25
1832_OG5_129657_4 - EUKARYOTES_YOL107W	YOL107W	YOL107W - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and colocalizes in a punctate pattern with the early golgi/COPI vesicles; YOL107W is not an essential protein	1	0	0	1	0.80952381	0.857142857	1	0.125
1833_OG5_129760_4 - EUKARYOTES_YGL086W	YGL086W	MAD1 - Coiled-coil protein involved in the spindle-assembly checkpoint; phosphorylated by Mps1p upon checkpoint activation which leads to inhibition of the activity of the anaphase promoting complex; forms a complex with Mad2p	1	0	0	1	0.666666667	1	1	0.1875
1834_OG5_127366_4 - EUKARYOTES_YGR037C	YGR037C	"ACB1 - Acyl-CoA-binding protein, transports newly synthesized acyl-CoA esters from fatty acid synthetase (Fas1p-Fas2p) to acyl-CoA-consuming processes; subject to starvation-induced, Grh1p-mediated unconventional secretion"	1	0	0.111111111	1	0.857142857	0.857142857	0.95	0.625
1835_OG5_128627_4 - EUKARYOTES_YDR243C	YDR243C	"PRP28 - RNA helicase in the DEAD-box family, involved in RNA isomerization at the 5' splice site"	1	0	0.055555556	1	0.857142857	0.857142857	0.95	0.5625
1836_OG5_127878_4 - EUKARYOTES_YER009W	YER009W	"NTF2 - Nuclear envelope protein, interacts with GDP-bound Gsp1p and with proteins of the nuclear pore to transport Gsp1p into the nucleus where it is an essential player in nucleocytoplasmic transport"	1	0	0	1	0.857142857	0.857142857	0.95	0.875
1837_OG5_128092_4 - EUKARYOTES_YOR358W	YOR358W	"HAP5 - Subunit of the heme-activated, glucose-repressed Hap2/3/4/5 CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; required for assembly and DNA binding activity of the complex"	1	0	0	1	0.714285714	1	0.95	0.5625
1838_OG5_128311_4 - EUKARYOTES_YMR156C	YMR156C	"TPP1 - DNA 3'-phosphatase that functions in repair of endogenous damage of double-stranded DNA, activity is specific for removal of 3' phosphates at strand breaks; has similarity to the l-2-haloacid dehalogenase superfamily"	1	0	0	1	0.857142857	0.857142857	0.95	0.8125
1839_OG5_128646_4 - EUKARYOTES_YLR150W	YLR150W	STM1 - Protein required for optimal translation under nutrient stress; perturbs association of Yef3p with ribosomes; involved in TOR signaling; binds G4 quadruplex and purine motif triplex nucleic acid; helps maintain telomere structure	1	0	0	1	0.714285714	1	0.95	0.25
1840_OG5_128706_4 - EUKARYOTES_YHR040W	YHR040W	BCD1 - Essential protein required for the accumulation of box C/D snoRNA	1	0	0	1	0.857142857	0.857142857	0.95	0.625
1841_OG5_129539_4 - EUKARYOTES_YGR072W	YGR072W	"UPF3 - Component of the nonsense-mediated mRNA decay (NMD) pathway, along with Nam7p and Nmd2p; involved in decay of mRNA containing nonsense codons; involved in telomere maintenance"	1	0	0	1	0.714285714	1	0.95	0.125
1842_OG5_129651_4 - EUKARYOTES_YLR007W	YLR007W	NSE1 - Essential subunit of the Mms21-Smc5-Smc6 complex; nuclear protein required for DNA repair and growth; has a nonstructural role in the maintenance of chromosomes	1	0	0	1	0.714285714	1	0.95	0.125
1843_OG5_129755_4 - EUKARYOTES_YPR018W	YPR018W	RLF2 - Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1) with Cac2p and Msi1p that assembles newly synthesized histones onto recently replicated DNA; involved in the maintenance of transcriptionally silent chromatin	1	0.0625	0	0.875	0.857142857	0.928571429	1	0.125
1844_OG5_127829_4 - EUKARYOTES_YDR381W	YDR381W	"YRA1 - RNA binding protein required for export of poly(A)+ mRNA from the nucleus; proposed to couple mRNA export with 3' end processing via its interactions with Mex67p and Pcf11p; functionally redundant with Yra2p, another REF family member"	1	0	0	0.875	0.857142857	0.928571429	1	0.5
1845_OG5_128152_4 - EUKARYOTES_YNR017W	YNR017W	"TIM23 - Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); involved in protein import into mitochondrial matrix and inner membrane; with Tim17p, contributes to architecture and function of the import channel"	1	0	0	0.875	0.857142857	0.928571429	1	0.5
1846_OG5_128317_4 - EUKARYOTES_YMR028W	YMR028W	TAP42 - Essential protein involved in the TOR signaling pathway; physically associates with the protein phosphatase 2A and the SIT4 protein phosphatase catalytic subunits	1	0	0	0.875	0.857142857	0.928571429	1	0.625
1847_OG5_128429_4 - EUKARYOTES_YML077W	YML077W	"BET5 - Component of the TRAPP (transport protein particle) complex, which plays an essential role in the vesicular transport from endoplasmic reticulum to Golgi"	1	0	0	0.875	0.857142857	0.928571429	1	0.75
1848_OG5_129076_4 - EUKARYOTES_YPR105C	YPR105C	"COG4 - Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments"	1	0	0	0.875	0.857142857	0.928571429	1	0.25
1849_OG5_129194_4 - EUKARYOTES_YDR449C	YDR449C	"UTP6 - Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA"	1	0	0	0.875	0.857142857	0.928571429	1	0.4375
1850_OG5_129269_4 - EUKARYOTES_YLR127C	YLR127C	"APC2 - Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the catalytic core of the APC/C; has similarity to cullin Cdc53p"	1	0	0	0.875	0.857142857	0.928571429	1	0.375
1851_OG5_129367_4 - EUKARYOTES_YNL245C	YNL245C	CWC25 - Splicing factor required for the first step of pre-mRNA splicing; binding to the spliceosome requires Prp2p and Yju2p; heat-stable protein; has similarity to S. pombe Cwf25p	1	0	0	0.875	0.857142857	0.928571429	1	0.3125
1852_OG5_129417_4 - EUKARYOTES_YDR293C	YDR293C	SSD1 - Translational repressor with a role in cell wall polar growth and integrity; regulated by Cbk1p phosphorylation to effect bud-specific translational control of specific mRNAs; interacts with TOR pathway components	1	0	0	0.875	0.857142857	0.928571429	1	0.0625
1853_OG5_129490_4 - EUKARYOTES_YHR156C	YHR156C	"LIN1 - Non-essential component of U5 snRNP; nuclear protein; physically interacts with Irr1p of cohesin complex; may link together proteins involved in chromosome segregation, mRNA splicing and DNA replication"	1	0	0	0.875	0.857142857	0.928571429	1	0.125
1854_OG5_129540_4 - EUKARYOTES_YCL045C	YCL045C	EMC1 - Member of a transmembrane complex required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; interacts with Gal80p	1	0	0	0.875	0.857142857	0.928571429	1	0.25
1855_OG5_129661_4 - EUKARYOTES_YLR085C	YLR085C	"ARP6 - Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A"	1	0	0	0.875	0.857142857	0.928571429	1	0.1875
1856_OG5_127766_4 - EUKARYOTES_YBR061C	YBR061C	"TRM7 - 2'-O-ribose methyltransferase, methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop"	1	0.0625	0.194444444	1	0.952380952	0.857142857	0.85	1
1857_OG5_127030_4 - EUKARYOTES_YKR099W	YKR099W	BAS1 - Myb-related transcription factor involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways; also involved in regulation of meiotic recombination at specific genes	1	0	0	1	0.80952381	1	0.85	0.4375
1858_OG5_126846_4 - EUKARYOTES_YOR039W	YOR039W	"CKB2 - Beta' regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerase"	1	0	0	0.875	0.904761905	0.928571429	0.95	1
1859_OG5_126846_4 - EUKARYOTES_YGL019W	YGL019W	"CKB1 - Beta regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases"	1	0	0	0.875	0.904761905	0.928571429	0.95	1
1860_OG5_128239_4 - EUKARYOTES_YGL231C	YGL231C	EMC4 - Member of a transmembrane complex required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; human ortholog TMEM85 may function in apoptosis	1	0	0	0.875	0.904761905	0.928571429	0.95	0.5625
1861_OG5_128254_4 - EUKARYOTES_YGR123C	YGR123C	PPT1 - Protein serine/threonine phosphatase with similarity to human phosphatase PP5; present in both the nucleus and cytoplasm; expressed during logarithmic growth; computational analyses suggest roles in phosphate metabolism and rRNA processing	1	0	0	0.875	0.904761905	0.928571429	0.95	0.8125
1862_OG5_128605_4 - EUKARYOTES_YGR063C	YGR063C	"SPT4 - Protein involved in the regulating Pol I and Pol II transcription, pre-mRNA processing, kinetochore function, and gene silencing; forms a complex with Spt5p"	1	0	0	0.875	0.904761905	0.928571429	0.95	0.75
1863_OG5_126830_4 - EUKARYOTES_YNL326C	YNL326C	"PFA3 - Palmitoyltransferase for Vac8p, required for vacuolar membrane fusion; contains an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; autoacylates; required for vacuolar integrity under stress conditions"	1	0	0	1	0.857142857	1	0.8	0.875
1864_OG5_129210_4 - EUKARYOTES_YMR102C	YMR102C	YMR102C - Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene	1	0	0	1	0.857142857	1	0.8	0.25
1865_OG5_129321_4 - EUKARYOTES_YOL076W	YOL076W	"MDM20 - Non-catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes N-acetylation of proteins with specific N-terminal sequences; involved in mitochondrial inheritance and actin assembly"	1	0	0	1	0.857142857	1	0.8	0.3125
1866_OG5_127895_4 - EUKARYOTES_YHR119W	YHR119W	"SET1 - Histone methyltransferase, subunit of the COMPASS (Set1C) complex which methylates histone H3 on lysine 4; required in transcriptional silencing near telomeres and at the silent mating type loci; contains a SET domain"	1	0	0.027777778	0.75	0.904761905	1	1	0.5
1867_OG5_127678_4 - EUKARYOTES_YJR090C	YJR090C	"GRR1 - F-box protein component of the SCF ubiquitin-ligase complex; involved in carbon catabolite repression, glucose-dependent divalent cation transport, high-affinity glucose transport, morphogenesis, and sulfite detoxification"	1	0	0	0.75	0.904761905	1	1	0.3125
1868_OG5_128034_4 - EUKARYOTES_YKL035W	YKL035W	"UGP1 - UDP-glucose pyrophosphorylase (UGPase), catalyses the reversible formation of UDP-Glc from glucose 1-phosphate and UTP, involved in a wide variety of metabolic pathways, expression modulated by Pho85p through Pho4p"	1	0	0	0.75	0.904761905	1	1	0.5
1869_OG5_128048_4 - EUKARYOTES_YGR261C	YGR261C	APL6 - Beta3-like subunit of the yeast AP-3 complex; functions in transport of alkaline phosphatase to the vacuole via the alternate pathway; exists in both cytosolic and peripherally associated membrane-bound pools	1	0	0	0.75	0.904761905	1	1	0.375
1870_OG5_128172_4 - EUKARYOTES_YKL213C	YKL213C	"DOA1 - WD repeat protein required for ubiquitin-mediated protein degradation, forms complex with Cdc48p, plays a role in controlling cellular ubiquitin concentration; also promotes efficient NHEJ in postdiauxic/stationary phase"	1	0	0	0.75	0.904761905	1	1	0.9375
1871_OG5_128382_4 - EUKARYOTES_YPL195W	YPL195W	"APL5 - Delta adaptin-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway, suppressor of loss of casein kinase 1 function"	1	0	0	0.75	0.904761905	1	1	0.5
1872_OG5_127924_4 - EUKARYOTES_YOR341W	YOR341W	RPA190 - RNA polymerase I largest subunit A190	1	0	0	0.75	0.952380952	1	0.95	1
1873_OG5_128796_4 - EUKARYOTES_YML018C	YML018C	YML018C - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of the vacuole; physical interaction with Atg27p suggests a possible role in autophagy; YML018C is not an essential gene	1	0	0.027777778	1	0.714285714	0.928571429	1	0.1875
1874_OG5_128796_4 - EUKARYOTES_YDR438W	YDR438W	THI74 - Mitochondrial transporter repressible by thiamine	1	0	0.027777778	1	0.714285714	0.928571429	1	0.1875
1875_OG5_127551_4 - EUKARYOTES_YDR457W	YDR457W	TOM1 - E3 ubiquitin ligase of the hect-domain class; has a role in mRNA export from the nucleus and may regulate transcriptional coactivators; involved in degradation of excess histones	1	0	0	1	0.714285714	0.928571429	1	0.875
1876_OG5_129039_4 - EUKARYOTES_YPL146C	YPL146C	NOP53 - Nucleolar protein; involved in biogenesis of the 60S subunit of the ribosome; interacts with rRNA processing factors Cbf5p and Nop2p; null mutant is viable but growth is severely impaired	1	0	0	1	0.857142857	0.785714286	1	0.375
1877_OG5_129906_4 - EUKARYOTES_YDR108W	YDR108W	"TRS85 - Subunit of TRAPPIII (transport protein particle), a multimeric guanine nucleotide-exchange factor for Ypt1p, required for membrane expansion during autophagy and the CVT pathway; directs Ypt1p to the PAS; late post-replication meiotic role"	1	0	0	1	0.761904762	0.928571429	0.95	0.125
1878_OG5_129535_4 - EUKARYOTES_YGL232W	YGL232W	"TAN1 - Putative tRNA acetyltransferase, RNA-binding protein required for the formation of the modified nucleoside N(4)-acetylcytidine in serine and leucine tRNAs but not required for the same modification in 18S rRNA"	1	0	0	1	0.80952381	0.928571429	0.9	0.1875
1879_OG5_129734_4 - EUKARYOTES_YNL253W	YNL253W	"TEX1 - Protein involved in mRNA export, component of the transcription export (TREX) complex"	1	0	0	1	0.80952381	0.928571429	0.9	0.125
1880_OG5_128452_4 - EUKARYOTES_YGL044C	YGL044C	RNA15 - Cleavage and polyadenylation factor I (CF I) component involved in cleavage and polyadenylation of mRNA 3' ends; interacts with the A-rich polyadenylation signal in complex with Rna14p and Hrp1p	1	0	0.055555556	0.875	0.761904762	1	1	0.5625
1881_OG5_126709_4 - EUKARYOTES_YNL275W	YNL275W	"BOR1 - Boron efflux transporter of the plasma membrane; binds HCO3-, I-, Br-, NO3- and Cl-; has similarity to the characterized boron efflux transporter A. thaliana BOR1"	1	0	0	0.875	0.761904762	1	1	0.0625
1882_OG5_127521_4 - EUKARYOTES_YGL200C	YGL200C	EMP24 - Component of the p24 complex; binds to GPI anchor proteins and mediates their efficient transport from the ER to the Golgi; integral membrane protein that associates with endoplasmic reticulum-derived COPII-coated vesicles	1	0	0	0.875	0.904761905	0.857142857	1	0.625
1883_OG5_127521_4 - EUKARYOTES_YDL018C	YDL018C	"ERP3 - Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport"	1	0	0	0.875	0.904761905	0.857142857	1	0.625
1884_OG5_127773_4 - EUKARYOTES_YMR304W	YMR304W	UBP15 - Ubiquitin-specific protease that may play a role in ubiquitin precursor processing	1	0	0	0.875	0.761904762	1	1	0.875
1885_OG5_127831_4 - EUKARYOTES_YDR394W	YDR394W	RPT3 - One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; substrate of N-acetyltransferase B	1	0	0	0.875	0.904761905	0.857142857	1	0.9375
1886_OG5_127876_4 - EUKARYOTES_YOR281C	YOR281C	PLP2 - Essential protein that interacts with the CCT (chaperonin containing TCP-1) complex to stimulate actin folding; has similarity to phosducins; null mutant lethality is complemented by mouse phosducin-like protein MgcPhLP	1	0	0	0.875	0.761904762	1	1	0.75
1887_OG5_128247_4 - EUKARYOTES_YNL313C	YNL313C	EMW1 - Essential conserved protein with a role in maintaining cell wall integrity; contains six TPR (tetratricopeptide repeat) domains clustered in the C-terminal region; conditional mutant is suppressed by overexpression of GFA1	1	0	0	0.875	0.904761905	0.857142857	1	0.8125
1888_OG5_128359_4 - EUKARYOTES_YKL073W	YKL073W	"LHS1 - Molecular chaperone of the endoplasmic reticulum lumen, involved in polypeptide translocation and folding; nucleotide exchange factor for the ER lumenal Hsp70 chaperone Kar2p; regulated by the unfolded protein response pathway"	1	0	0	0.875	0.904761905	0.857142857	1	0.75
1889_OG5_128892_4 - EUKARYOTES_YNL315C	YNL315C	"ATP11 - Molecular chaperone, required for the assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase"	1	0	0	0.875	0.761904762	1	1	0.5
1890_OG5_128916_4 - EUKARYOTES_YGR167W	YGR167W	"CLC1 - Clathrin light chain, subunit of the major coat protein involved in intracellular protein transport and endocytosis; thought to regulate clathrin function; two Clathrin heavy chains (CHC1) form the clathrin triskelion structural component"	1	0	0	0.875	0.761904762	1	1	0.125
1891_OG5_129126_4 - EUKARYOTES_YMR223W	YMR223W	UBP8 - Ubiquitin-specific protease that is a component of the SAGA (Spt-Ada-Gcn5-Acetyltransferase) acetylation complex; required for SAGA-mediated deubiquitination of histone H2B	1	0	0	0.875	0.761904762	1	1	0.125
1892_OG5_129251_4 - EUKARYOTES_YJR082C	YJR082C	EAF6 - Subunit of the NuA4 acetyltransferase complex that acetylates histone H4 and NuA3 acetyltransferase complex that acetylates histone H3	1	0	0	0.875	0.761904762	1	1	0.25
1893_OG5_129867_4 - EUKARYOTES_YLR191W	YLR191W	"PEX13 - Integral peroxisomal membrane protein required for translocation of peroxisomal matrix proteins, interacts with the PTS1 signal recognition factor Pex5p and the PTS2 signal recognition factor Pex7p, forms a complex with Pex14p and Pex17p"	1	0	0	0.875	0.761904762	1	1	0
1894_OG5_127420_4 - EUKARYOTES_YDR448W	YDR448W	"ADA2 - Transcription coactivator, component of the ADA and SAGA transcriptional adaptor/HAT (histone acetyltransferase) complexes"	1	0	0	0.875	0.80952381	1	0.95	0.6875
1895_OG5_128185_4 - EUKARYOTES_YGR223C	YGR223C	"HSV2 - Phosphatidylinositol 3,5-bisphosphate-binding protein, plays a role in micronucleophagy; predicted to fold as a seven-bladed beta-propeller; displays punctate cytoplasmic localization"	1	0	0	0.875	0.80952381	1	0.95	0.625
1896_OG5_127092_4 - EUKARYOTES_YOL123W	YOL123W	"HRP1 - Subunit of cleavage factor I, a five-subunit complex required for the cleavage and polyadenylation of pre-mRNA 3' ends; RRM-containing heteronuclear RNA binding protein and hnRNPA/B family member that binds to poly (A) signal sequences"	1	0	0	0.875	0.857142857	1	0.9	0.4375
1897_OG5_129088_4 - EUKARYOTES_YDR117C	YDR117C	"TMA64 - Protein of unknown function that associates with ribosomes; has a putative RNA binding domain; in mammals the corresponding protein, eIF2D, has been shown to possess translation initiation factor activity"	1	0	0	0.875	0.857142857	1	0.9	0.4375
1898_OG5_129590_4 - EUKARYOTES_YOR067C	YOR067C	"ALG8 - Glucosyl transferase, involved in N-linked glycosylation; adds glucose to the dolichol-linked oligosaccharide precursor prior to transfer to protein during lipid-linked oligosaccharide biosynthesis; similar to Alg6p"	1	0	0	0.875	0.857142857	1	0.9	0.3125
1899_OG5_128874_4 - EUKARYOTES_YNL286W	YNL286W	"CUS2 - Protein that binds to U2 snRNA and Prp11p, may be involved in U2 snRNA folding; contains two RNA recognition motifs (RRMs)"	1	0	0	0.875	0.904761905	1	0.85	0.625
1900_OG5_128814_4 - EUKARYOTES_YMR150C	YMR150C	"IMP1 - Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p"	1	0	0.027777778	1	0.761904762	0.857142857	1	0.5625
1901_OG5_128439_4 - EUKARYOTES_YKL010C	YKL010C	"UFD4 - Ubiquitin-protein ligase (E3) that interacts with Rpt4p and Rpt6p, two subunits of the 19S particle of the 26S proteasome; cytoplasmic E3 involved in the degradation of ubiquitin fusion proteins"	1	0	0	1	0.619047619	1	1	0.5
1902_OG5_128668_4 - EUKARYOTES_YGR270W	YGR270W	"YTA7 - Protein that localizes to chromatin and has a role in regulation of histone gene expression; has a bromodomain-like region that interacts with the N-terminal tail of histone H3, and an ATPase domain; potentially phosphorylated by Cdc28p"	1	0	0	1	0.619047619	1	1	0.3125
1903_OG5_128965_4 - EUKARYOTES_YNR020C	YNR020C	"ATP23 - Putative metalloprotease of the mitochondrial inner membrane, required for processing of Atp6p; has an additional role in assembly of the F0 sector of the F1F0 ATP synthase complex"	1	0	0	1	0.761904762	0.857142857	1	0.375
1904_OG5_129924_4 - EUKARYOTES_YBR279W	YBR279W	"PAF1 - Component of the Paf1p complex that binds to and modulates the activity of RNA polymerases I and II; required for expression of a subset of genes, including cell cycle-regulated genes; homolog of human PD2/hPAF1"	1	0	0	1	0.761904762	0.857142857	1	0.125
1905_OG5_128939_4 - EUKARYOTES_YNR032C-A	YNR032C-A	"HUB1 - Ubiquitin-like protein modifier; promotes alternative splicing of SRC1 pre-mRNA; binds non-covalently to the HIND domain of Snu66, may function in modification of Sph1p and Hbt1p, functionally complemented by the human or S. pombe ortholog; mechanism of Hub1p adduct formation not yet clear"	1	0	0	1	0.80952381	0.857142857	0.95	0.5625
1906_OG5_129429_4 - EUKARYOTES_YDR167W	YDR167W	"TAF10 - Subunit (145 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification"	1	0	0	1	0.80952381	0.857142857	0.95	0.25
1907_OG5_129456_4 - EUKARYOTES_YGR127W	YGR127W	"YGR127W - Putative protein of unknown function; expression is regulated by Msn2p/Msn4p, indicating a possible role in stress response"	1	0.0625	0.111111111	1	0.857142857	0.857142857	0.9	0
1908_OG5_129092_4 - EUKARYOTES_YGR047C	YGR047C	TFC4 - One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA domain of TFIIIC that binds BoxA DNA promoter sites of tRNA and similar genes; has TPR motifs; human homolog is TFIIIC-102	1	0	0.027777778	0.875	0.80952381	0.928571429	1	0.3125
1909_OG5_127787_4 - EUKARYOTES_YHR204W	YHR204W	"MNL1 - alpha-1,2-specific exomannosidase of the endoplasmic reticulum that generates a Man7GlcNac2 oligosaccharide signal on glycoproteins destined for ubiquitin-proteasome degradation"	1	0	0	0.875	0.80952381	0.928571429	1	0.25
1910_OG5_129154_4 - EUKARYOTES_YGL187C	YGL187C	"COX4 - Subunit IV of cytochrome c oxidase, the terminal member of the mitochondrial inner membrane electron transport chain; precursor N-terminal 25 residues are cleaved during mitochondrial import; phosphorylated; spermidine enhances translation"	1	0	0	0.875	0.80952381	0.928571429	1	0.125
1911_OG5_129529_4 - EUKARYOTES_YDR121W	YDR121W	DPB4 - Shared subunit of DNA polymerase (II) epsilon and of ISW2/yCHRAC chromatin accessibility complex; involved in both chromosomal DNA replication and in inheritance of telomeric silencing	1	0	0	0.875	0.80952381	0.928571429	1	0.1875
1912_OG5_128705_4 - EUKARYOTES_YDL029W	YDL029W	"ARP2 - Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity"	1	0	0	0.875	0.857142857	0.928571429	0.95	0.375
1913_OG5_128731_4 - EUKARYOTES_YGL127C	YGL127C	SOH1 - Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; involved in telomere maintenance; conserved with other metazoan MED31 subunits	1	0	0	0.875	0.857142857	0.928571429	0.95	0.625
1914_OG5_128911_4 - EUKARYOTES_YBR257W	YBR257W	"POP4 - Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P"	1	0	0	0.875	0.857142857	0.928571429	0.95	0.4375
1915_OG5_128923_4 - EUKARYOTES_YPR023C	YPR023C	"EAF3 - Esa1p-associated factor, nonessential component of the NuA4 acetyltransferase complex, homologous to Drosophila dosage compensation protein MSL3; plays a role in regulating Ty1 transposition"	1	0	0	0.875	0.857142857	0.928571429	0.95	0.25
1916_OG5_129043_4 - EUKARYOTES_YCR042C	YCR042C	"TAF2 - TFIID subunit (150 kDa), involved in RNA polymerase II transcription initiation"	1	0	0	0.875	0.857142857	0.928571429	0.95	0.3125
1917_OG5_127311_4 - EUKARYOTES_YNL293W	YNL293W	"MSB3 - GTPase-activating protein for Sec4p and several other Rab GTPases, regulates exocytosis via its action on Sec4p, also required for proper actin organization; similar to Msb4p; both Msb3p and Msb4p localize to sites of polarized growth"	1	0	0	1	0.80952381	1	0.8	0.5625
1918_OG5_127311_4 - EUKARYOTES_YOL112W	YOL112W	"MSB4 - GTPase-activating protein of the Ras superfamily that acts primarily on Sec4p, localizes to the bud site and bud tip, has similarity to Msb3p; msb3 msb4 double mutation causes defects in secretion and actin organization"	1	0	0	1	0.80952381	1	0.8	0.5625
1919_OG5_128442_4 - EUKARYOTES_YLR380W	YLR380W	CSR1 - Phosphatidylinositol transfer protein with a potential role in regulating lipid and fatty acid metabolism under heme-depleted conditions; interacts specifically with thioredoxin peroxidase; may have a role in oxidative stress resistance	1	0	0	1	0.80952381	1	0.8	0.0625
1920_OG5_129556_4 - EUKARYOTES_YGR096W	YGR096W	TPC1 - Mitochondrial membrane transporter that mediates uptake of the essential cofactor thiamine pyrophosphate (ThPP) into mitochondria; expression appears to be regulated by carbon source; member of the mitochondrial carrier family	1	0	0	1	0.80952381	1	0.8	0.125
1921_OG5_126767_4 - EUKARYOTES_YPL127C	YPL127C	"HHO1 - Histone H1, a linker histone required for nucleosome packaging at restricted sites; suppresses DNA repair involving homologous recombination; not required for telomeric silencing, basal transcriptional repression, or efficient sporulation"	1	0	0	0.875	0.904761905	0.928571429	0.9	0.1875
1922_OG5_128149_4 - EUKARYOTES_YBR265W	YBR265W	"TSC10 - 3-ketosphinganine reductase, catalyzes the second step in phytosphingosine synthesis, essential for growth in the absence of exogenous dihydrosphingosine or phytosphingosine, member of short chain dehydrogenase/reductase protein family"	1	0	0.083333333	0.75	0.857142857	1	1	0.625
1923_OG5_127746_4 - EUKARYOTES_YNL055C	YNL055C	"POR1 - Mitochondrial porin (voltage-dependent anion channel), outer membrane protein required for the maintenance of mitochondrial osmotic stability and mitochondrial membrane permeability; phosphorylated"	1	0	0	0.75	0.857142857	1	1	0.125
1924_OG5_127746_4 - EUKARYOTES_YIL114C	YIL114C	"POR2 - Putative mitochondrial porin (voltage-dependent anion channel), related to Por1p but not required for mitochondrial membrane permeability or mitochondrial osmotic stability"	1	0	0	0.75	0.857142857	1	1	0.125
1925_OG5_127992_4 - EUKARYOTES_YBR234C	YBR234C	"ARC40 - Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches"	1	0	0	0.75	0.857142857	1	1	0.4375
1926_OG5_128082_4 - EUKARYOTES_YOR036W	YOR036W	"PEP12 - Target membrane receptor (t-SNARE) for vesicular intermediates traveling between the Golgi apparatus and the vacuole; controls entry of biosynthetic, endocytic, and retrograde traffic into the prevacuolar compartment; syntaxin"	1	0	0	0.75	0.857142857	1	1	0.125
1927_OG5_128221_4 - EUKARYOTES_YPL045W	YPL045W	VPS16 - Subunit of the vacuole fusion and protein sorting HOPS complex and the CORVET tethering complex; part of the Class C Vps complex essential for membrane docking and fusion at Golgi-to-endosome and endosome-to-vacuole protein transport stages	1	0	0	0.75	0.857142857	1	1	0.8125
1928_OG5_128267_4 - EUKARYOTES_YNL037C	YNL037C	"IDH1 - Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase, which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle"	1	0	0	0.75	0.857142857	1	1	0.0625
1929_OG5_128778_4 - EUKARYOTES_YLR370C	YLR370C	"ARC18 - Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches"	1	0	0	0.75	0.857142857	1	1	0.3125
1930_OG5_128922_4 - EUKARYOTES_YEL002C	YEL002C	WBP1 - Beta subunit of the oligosaccharyl transferase (OST) glycoprotein complex; required for N-linked glycosylation of proteins in the endoplasmic reticulum	1	0	0	0.75	0.857142857	1	1	0.4375
1931_OG5_128966_4 - EUKARYOTES_YNR035C	YNR035C	"ARC35 - Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches; required for cortical localization of calmodulin"	1	0	0	0.75	0.857142857	1	1	0.3125
1932_OG5_129458_4 - EUKARYOTES_YKL028W	YKL028W	"TFA1 - TFIIE large subunit, involved in recruitment of RNA polymerase II to the promoter, activation of TFIIH, and promoter opening"	1	0	0	0.75	0.857142857	1	1	0.25
1933_OG5_129491_4 - EUKARYOTES_YOR160W	YOR160W	"MTR10 - Nuclear import receptor, mediates the nuclear localization of proteins involved in mRNA-nucleus export; promotes dissociation of mRNAs from the nucleus-cytoplasm mRNA shuttling protein Npl3p; required for retrograde import of mature tRNAs"	1	0	0	0.75	0.857142857	1	1	0.25
1934_OG5_129616_4 - EUKARYOTES_YFR002W	YFR002W	"NIC96 - Component of the nuclear pore complex, required for nuclear pore formation; forms a subcomplex with Nsp1p, Nup57p, and Nup49p"	1	0	0	0.75	0.857142857	1	1	0.1875
1935_OG5_129276_4 - EUKARYOTES_YDL047W	YDL047W	SIT4 - Type 2A-related serine-threonine phosphatase that functions in the G1/S transition of the mitotic cycle; cytoplasmic and nuclear protein that modulates functions mediated by Pkc1p including cell wall and actin cytoskeleton organization	1	0	0	1	0.857142857	1	0.75	0.3125
1936_OG5_129570_4 - EUKARYOTES_YNR038W	YNR038W	DBP6 - Essential protein involved in ribosome biogenesis; putative ATP-dependent RNA helicase of the DEAD-box protein family	1	0	0	1	0.857142857	1	0.75	0.375
1937_OG5_128786_4 - EUKARYOTES_YMR227C	YMR227C	"TAF7 - TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation"	1	0	0.027777778	0.75	0.904761905	1	0.95	0.25
1938_OG5_128500_4 - EUKARYOTES_YPL157W	YPL157W	"TGS1 - Trimethyl guanosine synthase, conserved nucleolar methyl transferase that converts the m(7)G cap structure of snRNAs, snoRNAs, and telomerase TLC1 RNA to m(2,2,7)G; also required for nucleolar assembly and splicing of meiotic pre-mRNAs"	1	0	0	0.75	0.904761905	1	0.95	0.6875
1939_OG5_128659_4 - EUKARYOTES_YER019C-A	YER019C-A	"SBH2 - Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p"	1	0	0	1	0.80952381	0.785714286	1	0.5625
1940_OG5_128659_4 - EUKARYOTES_YER087C-B	YER087C-B	SBH1 - Beta subunit of the Sec61p ER translocation complex (Sec61p-Sss1p-Sbh1p); involved in protein translocation into the endoplasmic reticulum; interacts with the exocyst complex and also with Rtn1p; homologous to Sbh2p	1	0	0	1	0.80952381	0.785714286	1	0.5625
1941_OG5_127811_4 - EUKARYOTES_YDL206W	YDL206W	YDL206W - Putative protein of unknown function; YDL206W is not an essential protein	1	0	0	1	0.666666667	0.928571429	1	0.0625
1942_OG5_127811_4 - EUKARYOTES_YJR106W	YJR106W	"ECM27 - Putative protein of unknown function; may play a role in cell wall biosynthesis, mutants are hypersensitive to Papulacandin B; null mutants have increased plasmid loss; displays a two-hybrid interaction with Pdr5p"	1	0	0	1	0.666666667	0.928571429	1	0.0625
1943_OG5_129966_4 - EUKARYOTES_YDR485C	YDR485C	"VPS72 - Htz1p-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting"	1	0	0	1	0.714285714	0.928571429	0.95	0.125
1944_OG5_128752_4 - EUKARYOTES_YJR063W	YJR063W	"RPA12 - RNA polymerase I subunit A12.2; contains two zinc binding domains, and the N terminal domain is responsible for anchoring to the RNA pol I complex"	1	0.125	0	1	0.857142857	0.785714286	0.95	0.375
1945_OG5_129169_4 - EUKARYOTES_YMR274C	YMR274C	RCE1 - Type II CAAX prenyl protease involved in the proteolysis and maturation of Ras and the a-factor mating pheromone	1	0	0	1	0.857142857	0.785714286	0.95	0.4375
1946_OG5_128595_4 - EUKARYOTES_YKL160W	YKL160W	ELF1 - Transcription elongation factor that contains a conserved zinc finger domain; implicated in the maintenance of proper chromatin structure in actively transcribed regions; deletion inhibits Brome mosaic virus (BMV) gene expression	1	0	0	1	0.761904762	0.928571429	0.9	0.6875
1947_OG5_129673_4 - EUKARYOTES_YLR065C	YLR065C	YLR065C - Putative protein of unknown function; YLR065C is not an essential gene	1	0	0	1	0.761904762	0.928571429	0.9	0.1875
1948_OG5_128457_4 - EUKARYOTES_YFR033C	YFR033C	"QCR6 - Subunit 6 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; highly acidic protein; required for maturation of cytochrome c1"	1	0	0	0.875	0.857142857	0.857142857	1	0.625
1949_OG5_128678_4 - EUKARYOTES_YNL148C	YNL148C	"ALF1 - Alpha-tubulin folding protein, similar to mammalian cofactor B; Alf1p-GFP localizes to cytoplasmic microtubules; required for the folding of alpha-tubulin and may play an additional role in microtubule maintenance"	1	0	0	0.875	0.857142857	0.857142857	1	0.6875
1950_OG5_128699_4 - EUKARYOTES_YDR060W	YDR060W	"MAK21 - Constituent of 66S pre-ribosomal particles, required for large (60S) ribosomal subunit biogenesis; involved in nuclear export of pre-ribosomes; required for maintenance of dsRNA virus; homolog of human CAATT-binding protein"	1	0	0	0.875	0.857142857	0.857142857	1	0.75
1951_OG5_129004_4 - EUKARYOTES_YDR361C	YDR361C	"BCP1 - Essential protein involved in nuclear export of Mss4p, which is a lipid kinase that generates phosphatidylinositol 4,5-biphosphate and plays a role in actin cytoskeleton organization and vesicular transport"	1	0	0	0.875	0.714285714	1	1	0.5625
1952_OG5_129097_4 - EUKARYOTES_YML038C	YML038C	"YMD8 - Putative nucleotide sugar transporter, has similarity to Vrg4p"	1	0	0	0.875	0.857142857	0.857142857	1	0.4375
1953_OG5_129415_4 - EUKARYOTES_YDR301W	YDR301W	"CFT1 - RNA-binding subunit of the mRNA cleavage and polyadenylation factor; involved in poly(A) site recognition and required for both pre-mRNA cleavage and polyadenylation, 51% sequence similarity with mammalian AAUAA-binding subunit of CPSF"	1	0	0	0.875	0.857142857	0.857142857	1	0.25
1954_OG5_129804_4 - EUKARYOTES_YBR231C	YBR231C	"SWC5 - Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A"	1	0	0	0.875	0.714285714	1	1	0.0625
1955_OG5_127135_4 - EUKARYOTES_YBR241C	YBR241C	"YBR241C - Putative transporter, member of the sugar porter family; green fluorescent protein (GFP)-fusion protein localizes to the vacuolar membrane; YBR241C is not an essential gene"	1	0	0.027777778	0.875	0.761904762	1	0.95	0.375
1956_OG5_128115_4 - EUKARYOTES_YNL255C	YNL255C	"GIS2 - Translational activator for mRNAs with internal ribosome entry sites; associates with polysomes and binds to a specific subset of mRNAs; ortholog of human ZNF9/CNBP, a gene involved in myotonic dystrophy type 2"	1	0	0	0.875	0.761904762	1	0.95	0.3125
1957_OG5_128458_4 - EUKARYOTES_YLR128W	YLR128W	DCN1 - Scaffold-type E3 ligase required for cullin neddylation and ubiquitin ligase activation; contains a ubiquitin-binding domain (UBA) for ubiquitin and Nedd8 (Rub1p) interaction and a PONY domain involved in cullin binding and neddylation	1	0	0	0.875	0.761904762	1	0.95	0.375
1958_OG5_128484_4 - EUKARYOTES_YJL072C	YJL072C	"PSF2 - Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery"	1	0	0	0.875	0.904761905	0.857142857	0.95	0.5625
1959_OG5_129497_4 - EUKARYOTES_YOR194C	YOR194C	"TOA1 - TFIIA large subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to largest and second largest subunits of human and Drosophila TFIIA"	1	0	0	0.875	0.761904762	1	0.95	0.1875
1960_OG5_128822_4 - EUKARYOTES_YLR074C	YLR074C	BUD20 - Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern	1	0	0	0.875	0.952380952	0.857142857	0.9	0.5
1961_OG5_128872_4 - EUKARYOTES_YNL200C	YNL200C	"YNL200C - Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"	1	0.0625	0.027777778	0.75	0.904761905	0.928571429	1	0.375
1962_OG5_127611_4 - EUKARYOTES_YKL193C	YKL193C	"SDS22 - Conserved nuclear regulatory subunit of Glc7p type 1 protein serine-threonine phosphatase (PP1), functions positively with Glc7p to promote dephosphorylation of nuclear substrates required for chromosome transmission during mitosis"	1	0	0.138888889	0.75	0.904761905	0.928571429	1	0.875
1963_OG5_127935_4 - EUKARYOTES_YOR336W	YOR336W	"KRE5 - Protein required for beta-1,6 glucan biosynthesis; mutations result in aberrant morphology and severe growth defects"	1	0	0	0.75	0.904761905	0.928571429	1	0.3125
1964_OG5_128281_4 - EUKARYOTES_YJL024C	YJL024C	"APS3 - Small subunit of the clathrin-associated adaptor complex AP-3, which is involved in vacuolar protein sorting; related to the sigma subunit of the mammalian clathrin AP-3 complex; suppressor of loss of casein kinase 1 function"	1	0	0	0.75	0.904761905	0.928571429	1	0.5
1965_OG5_127682_4 - EUKARYOTES_YNL267W	YNL267W	"PIK1 - Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton"	1	0	0	1	0.904761905	0.928571429	0.75	0.9375
1966_OG5_128648_4 - EUKARYOTES_YDR255C	YDR255C	"RMD5 - Conserved protein that has an E3-like ubiquitin ligase activity necessary for polyubiquitination and degradation of the gluconeogenic enzyme fructose-1,6-bisphosphatase; also required for sporulation; has a degenerate RING finger domain"	1	0	0	0.875	0.857142857	1	0.85	0.1875
1967_OG5_128384_4 - EUKARYOTES_YLR398C	YLR398C	"SKI2 - Ski complex component and putative RNA helicase, mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay"	1	0	0	0.75	0.952380952	0.928571429	0.95	0.625
1968_OG5_127590_4 - EUKARYOTES_YJL167W	YJL167W	"ERG20 - Farnesyl pyrophosphate synthetase, has both dimethylallyltranstransferase and geranyltranstransferase activities; catalyzes the formation of C15 farnesyl pyrophosphate units for isoprenoid and sterol biosynthesis"	1	0.125	0.083333333	1	0.857142857	0.714285714	1	0.875
1969_OG5_128704_4 - EUKARYOTES_YPL076W	YPL076W	"GPI2 - Protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; homologous to the human PIG-C protein"	1	0	0	1	0.714285714	0.857142857	1	0.6875
1970_OG5_128978_4 - EUKARYOTES_YPL063W	YPL063W	TIM50 - Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); acts as receptor for the TIM23 complex guiding incoming precursors from the TOM complex; may control the gating of the Tim23p-Tim17p channel	1	0	0	1	0.857142857	0.714285714	1	0.5625
1971_OG5_129747_4 - EUKARYOTES_YJL010C	YJL010C	NOP9 - Essential subunit of U3-containing 90S preribosome involved in production of 18S rRNA and assembly of small ribosomal subunit; also part of pre-40S ribosome and required for its export into cytoplasm; binds RNA and contains pumilio domain	1	0	0	1	0.714285714	0.857142857	1	0.3125
1972_OG5_129759_4 - EUKARYOTES_YGR099W	YGR099W	"TEL2 - Essential DNA-binding protein specific to single-stranded yeast telomeric DNA repeats, required for telomere length regulation and telomere position effect"	1	0	0	1	0.571428571	1	1	0.1875
1973_OG5_129864_4 - EUKARYOTES_YEL055C	YEL055C	"POL5 - DNA Polymerase phi; has sequence similarity to the human MybBP1A and weak sequence similarity to B-type DNA polymerases, not required for chromosomal DNA replication; required for the synthesis of rRNA"	1	0	0	1	0.571428571	1	1	0.0625
1974_OG5_128596_4 - EUKARYOTES_YBL071W-A	YBL071W-A	"KTI11 - Zn-ribbon protein that co-purifies with Dph1 and Dph2 in a complex required for synthesis of diphthamide on translation factor eEF2 and with Elongator subunits Iki3p, Elp2p, and Elp3p involved in modification of wobble nucleosides in tRNAs"	1	0	0	1	0.761904762	0.857142857	0.95	0.75
1975_OG5_129337_4 - EUKARYOTES_YGL153W	YGL153W	"PEX14 - Peroxisomal membrane peroxin that is a central component of the peroxisomal protein import machinery; interacts with both PTS1 (Pex5p) and PTS2 (Pex7p), peroxisomal matrix protein signal recognition factors and membrane receptor Pex13p"	1	0	0	1	0.619047619	1	0.95	0.1875
1976_OG5_129619_4 - EUKARYOTES_YJL104W	YJL104W	PAM16 - Constituent of the import motor (PAM complex) component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); forms a 1:1 subcomplex with Pam18p and inhibits its cochaperone activity; contains a J-like domain	1	0	0	1	0.761904762	0.857142857	0.95	0.1875
1977_OG5_127865_4 - EUKARYOTES_YBR026C	YBR026C	"ETR1 - 2-enoyl thioester reductase, member of the medium chain dehydrogenase/reductase family; localized to in mitochondria, where it has a probable role in fatty acid synthesis"	1	0	0.055555556	1	0.80952381	0.857142857	0.9	0.3125
1978_OG5_128693_4 - EUKARYOTES_YGR095C	YGR095C	RRP46 - Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp46p (EXOSC5)	1	0	0	1	0.80952381	0.857142857	0.9	0.6875
1979_OG5_129723_4 - EUKARYOTES_YMR272C	YMR272C	"SCS7 - Sphingolipid alpha-hydroxylase, functions in the alpha-hydroxylation of sphingolipid-associated very long chain fatty acids, has both cytochrome b5-like and hydroxylase/desaturase domains, not essential for growth"	1	0	0.055555556	0.875	0.761904762	0.928571429	1	0.125
1980_OG5_129131_4 - EUKARYOTES_YOR115C	YOR115C	TRS33 - One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic	1	0	0	0.875	0.761904762	0.928571429	1	0.4375
1981_OG5_128397_4 - EUKARYOTES_YLR066W	YLR066W	"SPC3 - Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC22/23"	1	0	0	0.875	0.904761905	0.785714286	1	0.625
1982_OG5_129809_4 - EUKARYOTES_YDR145W	YDR145W	"TAF12 - Subunit (61/68 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H2A"	1	0	0	1	0.714285714	1	0.85	0.125
1983_OG5_128841_4 - EUKARYOTES_YMR296C	YMR296C	"LCB1 - Component of serine palmitoyltransferase, responsible along with Lcb2p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine"	1	0	0	0.875	0.80952381	0.928571429	0.95	0.5
1984_OG5_129222_4 - EUKARYOTES_YNL329C	YNL329C	PEX6 - AAA-peroxin that heterodimerizes with AAA-peroxin Pex1p and participates in the recycling of peroxisomal signal receptor Pex5p from the peroxisomal membrane to the cystosol	1	0	0	0.875	0.80952381	0.928571429	0.95	0.375
1985_OG5_129396_4 - EUKARYOTES_YLR051C	YLR051C	FCF2 - Essential nucleolar protein involved in the early steps of 35S rRNA processing; interacts with Faf1p; member of a transcriptionally co-regulated set of genes called the RRB regulon	1	0	0	0.875	0.857142857	0.928571429	0.9	0.375
1986_OG5_127637_4 - EUKARYOTES_YDL234C	YDL234C	"GYP7 - GTPase-activating protein for yeast Rab family members including: Ypt7p (most effective), Ypt1p, Ypt31p, and Ypt32p (in vitro); involved in vesicle mediated protein trafficking"	1	0	0	0.75	0.80952381	1	1	0.3125
1987_OG5_128044_4 - EUKARYOTES_YLR328W	YLR328W	"NMA1 - Nicotinic acid mononucleotide adenylyltransferase, involved in pathways of NAD biosynthesis, including the de novo, NAD(+) salvage, and nicotinamide riboside salvage pathways"	1	0	0	0.75	0.80952381	1	1	0.4375
1988_OG5_128044_4 - EUKARYOTES_YGR010W	YGR010W	"NMA2 - Nicotinic acid mononucleotide adenylyltransferase, involved in de novo and salvage synthesis of NAD(+)"	1	0	0	0.75	0.80952381	1	1	0.4375
1989_OG5_128062_4 - EUKARYOTES_YIR008C	YIR008C	"PRI1 - Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair"	1	0	0	0.75	0.952380952	0.857142857	1	1
1990_OG5_128209_4 - EUKARYOTES_YER164W	YER164W	"CHD1 - Nucleosome remodeling factor that functions in regulation of transcription elongation; contains a chromo domain, a helicase domain and a DNA-binding domain; component of both the SAGA and SLIK complexes"	1	0	0	0.75	0.80952381	1	1	0.5625
1991_OG5_128321_4 - EUKARYOTES_YMR231W	YMR231W	PEP5 - Component of CORVET tethering complex; peripheral vacuolar membrane protein required for protein trafficking and vacuole biogenesis; interacts with Pep7p	1	0	0	0.75	0.80952381	1	1	0.8125
1992_OG5_128473_4 - EUKARYOTES_YAL048C	YAL048C	"GEM1 - Evolutionarily-conserved tail-anchored outer mitochondrial membrane GTPase which regulates mitochondrial morphology; cells lacking Gem1p contain collapsed, globular, or grape-like mitochondria; not required for pheromone-induced cell death"	1	0	0	0.75	0.80952381	1	1	0.125
1993_OG5_129507_4 - EUKARYOTES_YDR228C	YDR228C	"PCF11 - mRNA 3' end processing factor, essential component of cleavage and polyadenylation factor IA (CF IA), involved in pre-mRNA 3' end processing and in transcription termination; binds C-terminal domain of largest subunit of RNA pol II (Rpo21p)"	1	0	0	0.75	0.80952381	1	1	0.125
1994_OG5_129248_4 - EUKARYOTES_YJR024C	YJR024C	MDE1 - 5'-methylthioribulose-1-phosphate dehydratase; acts in the methionine salvage pathway; potential Smt3p sumoylation substrate; expression downregulated by caspofungin and deletion mutant is caspofungin resistant	1	0	0.138888889	0.75	0.857142857	1	0.95	0.125
1995_OG5_128651_4 - EUKARYOTES_YPL167C	YPL167C	"REV3 - Catalytic subunit of DNA polymerase zeta, involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair"	1	0	0	0.75	0.857142857	1	0.95	0.5625
1996_OG5_129283_4 - EUKARYOTES_YEL053C	YEL053C	"MAK10 - Non-catalytic subunit of N-terminal acetyltransferase of the NatC type, required for replication of dsRNA virus; expression is glucose-repressible"	1	0	0	0.75	0.857142857	1	0.95	0.125
1997_OG5_129582_4 - EUKARYOTES_YPR135W	YPR135W	"CTF4 - Chromatin-associated protein, required for sister chromatid cohesion; interacts with DNA polymerase alpha (Pol1p) and may link DNA synthesis to sister chromatid cohesion"	1	0	0	0.75	0.904761905	1	0.9	0.1875
1998_OG5_127709_4 - EUKARYOTES_YEL042W	YEL042W	"GDA1 - Guanosine diphosphatase located in the Golgi, involved in the transport of GDP-mannose into the Golgi lumen by converting GDP to GMP after mannose is transferred its substrate"	1	0	0	1	0.619047619	0.928571429	1	0.5
1999_OG5_129503_4 - EUKARYOTES_YDR529C	YDR529C	"QCR7 - Subunit 7 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the mitochondrial matrix; N-terminus appears to play a role in complex assembly"	1	0	0	1	0.666666667	0.928571429	0.95	0.125
2000_OG5_128280_4 - EUKARYOTES_YHR086W	YHR086W	"NAM8 - RNA binding protein, component of the U1 snRNP protein; mutants are defective in meiotic recombination and in formation of viable spores, involved in the formation of DSBs through meiosis-specific splicing of MER2 pre-mRNA"	1	0	0	1	0.714285714	0.928571429	0.9	0.3125
2001_OG5_128280_4 - EUKARYOTES_YBR212W	YBR212W	NGR1 - RNA binding protein that negatively regulates growth rate; interacts with the 3' UTR of the mitochondrial porin (POR1) mRNA and enhances its degradation; overexpression impairs mitochondrial function; expressed in stationary phase	1	0	0	1	0.714285714	0.928571429	0.9	0.3125
2002_OG5_129526_4 - EUKARYOTES_YLR247C	YLR247C	IRC20 - Putative helicase; localizes to the mitochondrion and the nucleus; YLR247C is not an essential gene; null mutant displays increased levels of spontaneous Rad52p foci	1	0	0	1	0.714285714	0.928571429	0.9	0.25
2003_OG5_128118_4 - EUKARYOTES_YDR519W	YDR519W	"FPR2 - Membrane-bound peptidyl-prolyl cis-trans isomerase (PPIase), binds to the drugs FK506 and rapamycin; expression pattern suggests possible involvement in ER protein trafficking"	1	0	0.194444444	1	0.857142857	0.785714286	0.9	0.4375
2004_OG5_128367_4 - EUKARYOTES_YJR017C	YJR017C	ESS1 - Peptidylprolyl-cis/trans-isomerase (PPIase) specific for phosphorylated serine and threonine residues N-terminal to proline; regulates phosphorylation of the RNA polymerase II large subunit (Rpo21p) C-terminal domain	1	0	0.083333333	0.875	0.952380952	0.714285714	1	0.75
2005_OG5_128066_4 - EUKARYOTES_YNR046W	YNR046W	TRM112 - Subunit of tRNA methyltransferase (MTase) complexes in combination with Trm9p and Trm11p; subunit of complex with Mtq2p that methylates Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; deletion confers resistance to zymocin	1	0	0	0.875	0.952380952	0.714285714	1	0.75
2006_OG5_128310_4 - EUKARYOTES_YFL042C	YFL042C	YFL042C - Putative protein of unknown function; YFL042C is not an essential gene	1	0	0	0.875	0.666666667	1	1	0.1875
2007_OG5_128310_4 - EUKARYOTES_YLR072W	YLR072W	YLR072W - Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YLR072W is not an esssential gene	1	0	0	0.875	0.666666667	1	1	0.1875
2008_OG5_128310_4 - EUKARYOTES_YDR326C	YDR326C	YSP2 - Protein involved in programmed cell death; mutant shows resistance to cell death induced by amiodarone or intracellular acidification	1	0	0	0.875	0.666666667	1	1	0.1875
2009_OG5_128310_4 - EUKARYOTES_YHR080C	YHR080C	"YHR080C - Protein of unknown function that may interact with ribosomes, based on co-purification experiments; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"	1	0	0	0.875	0.666666667	1	1	0.1875
2010_OG5_128805_4 - EUKARYOTES_YBR164C	YBR164C	"ARL1 - Soluble GTPase with a role in regulation of membrane traffic; regulates potassium influx; G protein of the Ras superfamily, similar to ADP-ribosylation factor"	1	0	0	0.875	0.857142857	0.857142857	0.95	0.5625
2011_OG5_128836_4 - EUKARYOTES_YDL149W	YDL149W	"ATG9 - Transmembrane protein involved in forming Cvt and autophagic vesicles; cycles between the phagophore assembly site (PAS) and other cytosolic punctate structures, not found in autophagosomes; may be involved in membrane delivery to the PAS"	1	0	0	0.875	0.761904762	1	0.9	0.3125
2012_OG5_129817_4 - EUKARYOTES_YKR016W	YKR016W	FCJ1 - Mitochondrial inner membrane protein involved in formation and molecular structure of crista junctions; impairs oligomerization of F1F0-ATP synthase; null shows altered mitochondrial morphology and abnormal mitochondrial genome maintenance	1	0	0.055555556	0.75	0.857142857	0.928571429	1	0.0625
2013_OG5_128230_4 - EUKARYOTES_YEL012W	YEL012W	"UBC8 - Ubiquitin-conjugating enzyme that negatively regulates gluconeogenesis by mediating the glucose-induced ubiquitination of fructose-1,6-bisphosphatase (FBPase); cytoplasmic enzyme that catalyzes the ubiquitination of histones in vitro"	1	0	0	0.75	0.857142857	0.928571429	1	0.75
2014_OG5_128232_4 - EUKARYOTES_YHR089C	YHR089C	"GAR1 - Protein component of the H/ACA snoRNP pseudouridylase complex, involved in the modification and cleavage of the 18S pre-rRNA"	1	0	0	0.75	0.857142857	0.928571429	1	0.9375
2015_OG5_128622_4 - EUKARYOTES_YGL142C	YGL142C	"GPI10 - Integral membrane protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; putative alpha 1,2 mannosyltransferase required for addition of the third mannose onto the GPI core structure; human PIG-Bp is a functional homolog"	1	0	0	0.75	0.857142857	0.928571429	1	0.5625
2016_OG5_128881_4 - EUKARYOTES_YIL097W	YIL097W	"FYV10 - Protein of unknown function, required for survival upon exposure to K1 killer toxin; involved in proteasome-dependent catabolite inactivation of FBPase; contains CTLH domain; plays role in anti-apoptosis"	1	0	0	0.75	0.857142857	0.928571429	1	0.5
2017_OG5_129564_4 - EUKARYOTES_YLL035W	YLL035W	GRC3 - Polynucleotide kinase present on rDNA that is required for efficient transcription termination by RNA polymerase I; required for cell growth; mRNA is cell-cycle regulated	1	0	0	0.75	0.857142857	0.928571429	1	0.1875
2018_OG5_129597_4 - EUKARYOTES_YPR143W	YPR143W	"RRP15 - Nucleolar protein, constituent of pre-60S ribosomal particles; required for proper processing of the 27S pre-rRNA at the A3 and B1 sites to yield mature 5.8S and 25S rRNAs"	1	0	0	0.75	0.857142857	0.928571429	1	0.1875
2019_OG5_129827_4 - EUKARYOTES_YIL063C	YIL063C	"YRB2 - Protein of unknown function involved in nuclear processes of the Ran-GTPase cycle; involved in nuclear protein export; contains Ran Binding Domain and FxFG repeats; interacts with Srm1p, GTP-Gsp1p, Rna1p and Crm1p; is not essential"	1	0	0	0.75	0.857142857	0.928571429	1	0.125
2020_OG5_127639_4 - EUKARYOTES_YDR075W	YDR075W	"PPH3 - Catalytic subunit of protein phosphatase PP4 complex; active complex is composed of Pph3p and Psy2p, with Psy4p apparently providing additional substrate specificity in some cases; regulates recovery from the DNA damage checkpoint and also the gene conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair; involved in activation of Gln3p to alleviate nitrogen catabolite repression; Pph3p and Psy2p localize to foci on meiotic chromosomes"	1	0	0	1	0.904761905	0.928571429	0.7	0.875
2021_OG5_129525_4 - EUKARYOTES_YDR283C	YDR283C	"GCN2 - Protein kinase, phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation; activated by uncharged tRNAs and the Gcn1p-Gcn20p complex; contributes to DNA damage checkpoint control"	1	0	0	0.625	0.904761905	1	1	0.3125
2022_OG5_127088_4 - EUKARYOTES_YDR284C	YDR284C	"DPP1 - Diacylglycerol pyrophosphate (DGPP) phosphatase, zinc-regulated vacuolar membrane-associated lipid phosphatase, dephosphorylates DGPP to phosphatidate (PA) and Pi, then PA to diacylglycerol; involved in lipid signaling and cell metabolism"	1	0	0	1	0.571428571	1	0.95	0.375
2023_OG5_129188_4 - EUKARYOTES_YOL146W	YOL146W	"PSF3 - Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery"	1	0	0	1	0.714285714	0.857142857	0.95	0.4375
2024_OG5_129139_4 - EUKARYOTES_YJL091C	YJL091C	"GWT1 - Protein involved in the inositol acylation of glucosaminyl phosphatidylinositol (GlcN-PI) to form glucosaminyl(acyl)phosphatidylinositol (GlcN(acyl)PI), an intermediate in the biosynthesis of glycosylphosphatidylinositol (GPI) anchors"	1	0	0	0.875	0.714285714	0.928571429	1	0.5625
2025_OG5_129229_4 - EUKARYOTES_YPL042C	YPL042C	"SSN3 - Cyclin-dependent protein kinase, component of RNA polymerase II holoenzyme; involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression"	1	0	0	0.875	0.714285714	0.928571429	1	0.125
2026_OG5_129803_4 - EUKARYOTES_YKL082C	YKL082C	"RRP14 - Essential protein, constituent of 66S pre-ribosomal particles; interacts with proteins involved in ribosomal biogenesis and cell polarity; member of the SURF-6 family"	1	0	0	0.875	0.714285714	0.928571429	1	0.125
2027_OG5_130015_4 - EUKARYOTES_YDL116W	YDL116W	"NUP84 - Subunit of the nuclear pore complex (NPC), forms a subcomplex with Nup85p, Nup120p, Nup145p-C, Sec13p, and Seh1p that plays a role in nuclear mRNA export and NPC biogenesis"	1	0	0	0.875	0.714285714	0.928571429	1	0.0625
2028_OG5_129843_4 - EUKARYOTES_YLR201C	YLR201C	COQ9 - Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes	1	0	0.083333333	1	0.666666667	1	0.85	0.125
2029_OG5_127661_4 - EUKARYOTES_YPL249C	YPL249C	"GYP5 - GTPase-activating protein (GAP) for yeast Rab family members, involved in ER to Golgi trafficking; exhibits GAP activity toward Ypt1p that is stimulated by Gyl1p, also acts on Sec4p; interacts with Gyl1p, Rvs161p and Rvs167p"	1	0	0.027777778	0.875	0.761904762	0.928571429	0.95	0.625
2030_OG5_128839_4 - EUKARYOTES_YBR091C	YBR091C	"TIM12 - Essential protein of the inner mitochondrial membrane, peripherally localized; component of the TIM22 complex, which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins"	1	0	0	0.875	0.761904762	0.928571429	0.95	0.4375
2031_OG5_128839_4 - EUKARYOTES_YHR005C-A	YHR005C-A	"TIM10 - Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner membrane"	1	0	0	0.875	0.761904762	0.928571429	0.95	0.4375
2032_OG5_127595_4 - EUKARYOTES_YOR290C	YOR290C	SNF2 - Catalytic subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; contains DNA-stimulated ATPase activity; functions interdependently in transcriptional activation with Snf5p and Snf6p	1	0	0	0.75	0.761904762	1	1	0.4375
2033_OG5_127595_4 - EUKARYOTES_YIL126W	YIL126W	STH1 - ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; essential helicase-related protein homologous to Snf2p	1	0	0	0.75	0.761904762	1	1	0.4375
2034_OG5_128158_4 - EUKARYOTES_YCL011C	YCL011C	"GBP2 - Poly(A+) RNA-binding protein, involved in the export of mRNAs from the nucleus to the cytoplasm; similar to Hrb1p and Npl3p; also binds single-stranded telomeric repeat sequence in vitro"	1	0	0	0.75	0.761904762	1	1	0.6875
2035_OG5_128158_4 - EUKARYOTES_YNL004W	YNL004W	"HRB1 - Poly(A+) RNA-binding protein, involved in the export of mRNAs from the nucleus to the cytoplasm; similar to Gbp2p and Npl3p"	1	0	0	0.75	0.761904762	1	1	0.6875
2036_OG5_128246_4 - EUKARYOTES_YHL017W	YHL017W	YHL017W - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein co-localizes with clathrin-coated vesicles	1	0	0	0.75	0.761904762	1	1	0.3125
2037_OG5_128246_4 - EUKARYOTES_YKL039W	YKL039W	"PTM1 - Protein of unknown function, copurifies with late Golgi vesicles containing the v-SNARE Tlg2p"	1	0	0	0.75	0.761904762	1	1	0.3125
2038_OG5_128901_4 - EUKARYOTES_YMR076C	YMR076C	"PDS5 - Protein required for establishment and maintenance of sister chromatid condensation and cohesion, colocalizes with cohesin on chromosomes, may function as a protein-protein interaction scaffold; also required during meiosis"	1	0	0	0.75	0.761904762	1	1	0.125
2039_OG5_128942_4 - EUKARYOTES_YBR123C	YBR123C	TFC1 - One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA globular domain of TFIIIC that binds DNA at the BoxA promoter sites of tRNA and similar genes; human homolog is TFIIIC-63	1	0	0	0.75	0.761904762	1	1	0.6875
2040_OG5_128975_4 - EUKARYOTES_YPR100W	YPR100W	MRPL51 - Mitochondrial ribosomal protein of the large subunit	1	0	0	0.75	0.904761905	0.857142857	1	0.5
2041_OG5_129778_4 - EUKARYOTES_YCL031C	YCL031C	RRP7 - Essential protein involved in rRNA processing and ribosome biogenesis	1	0	0	0.75	0.761904762	1	1	0.125
2042_OG5_129142_4 - EUKARYOTES_YKR009C	YKR009C	FOX2 - Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities	1	0	0.111111111	0.75	0.80952381	1	0.95	0.1875
2043_OG5_127625_4 - EUKARYOTES_YIL047C	YIL047C	SYG1 - Plasma membrane protein of unknown function; truncation and overexpression suppresses lethality of G-alpha protein deficiency	1	0	0	0.75	0.80952381	1	0.95	0.6875
2044_OG5_129078_4 - EUKARYOTES_YGR274C	YGR274C	"TAF1 - TFIID subunit (145 kDa), involved in RNA polymerase II transcription initiation; possesses in vitro histone acetyltransferase activity but its role in vivo appears to be minor; involved in promoter binding and G1/S progression"	1	0	0	0.75	0.80952381	1	0.95	0.3125
2045_OG5_129144_4 - EUKARYOTES_YNL219C	YNL219C	"ALG9 - Mannosyltransferase, involved in N-linked glycosylation; catalyzes the transfer of mannose from Dol-P-Man to lipid-linked oligosaccharides; mutation of the human ortholog causes type 1 congenital disorders of glycosylation"	1	0	0	0.75	0.80952381	1	0.95	0.3125
2046_OG5_129428_4 - EUKARYOTES_YDR159W	YDR159W	"SAC3 - Nuclear pore-associated protein, required for biogenesis of the small ribosomal subunit; forms a complex with Thp1p that is involved in transcription and in mRNA export from the nucleus"	1	0	0	0.75	0.80952381	1	0.95	0.1875
2047_OG5_129968_4 - EUKARYOTES_YDR311W	YDR311W	"TFB1 - Subunit of TFIIH and nucleotide excision repair factor 3 complexes, required for nucleotide excision repair, target for transcriptional activators"	1	0	0	0.75	0.80952381	1	0.95	0.125
2048_OG5_127987_4 - EUKARYOTES_YDR086C	YDR086C	"SSS1 - Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p) that forms a channel for passage of secretory proteins through the endoplasmic reticulum membrane, and of the Ssh1p complex (Ssh1p-Sbh2p-Sss1p); interacts with Ost4p and Wbp1p"	1	0	0	0.875	0.904761905	0.928571429	0.8	0.8125
2049_OG5_127816_4 - EUKARYOTES_YNL186W	YNL186W	UBP10 - Ubiquitin-specific protease that deubiquitinates ubiquitin-protein moieties; may regulate silencing by acting on Sir4p; involved in posttranscriptionally regulating Gap1p and possibly other transporters; primarily located in the nucleus	1	0	0	1	0.857142857	1	0.65	0.8125
2050_OG5_127442_4 - EUKARYOTES_YER029C	YER029C	"SMB1 - Core Sm protein Sm B; part of heteroheptameric complex (with Smd1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm B and Sm B'"	1	0	0	0.625	0.952380952	0.928571429	1	0.9375
2051_OG5_127901_4 - EUKARYOTES_YJL141C	YJL141C	"YAK1 - Serine-threonine protein kinase; component of a glucose-sensing system that inhibits growth in response to glucose availability; upon nutrient deprivation Yak1p phosphorylates Pop2p to regulate mRNA deadenylation, the co-repressor Crf1p to inhibit transcription of ribosomal genes, and the stress-responsive transcription factors Hsf1p and Msn2p; nuclear localization negatively regulated by the Ras/PKA signaling pathway in the presence of glucose"	1	0	0	0.75	0.904761905	1	0.85	0.3125
2052_OG5_128347_4 - EUKARYOTES_YKL154W	YKL154W	"SRP102 - Signal recognition particle (SRP) receptor beta subunit; involved in SRP-dependent protein targeting; anchors the alpha subunit, Srp101p to the ER membrane"	1	0	0	1	0.857142857	0.642857143	1	0.75
2053_OG5_129016_4 - EUKARYOTES_YGL212W	YGL212W	VAM7 - Vacuolar SNARE protein that functions with Vam3p in vacuolar protein trafficking; has an N-terminal PX domain (phosphoinositide-binding module) that binds PtdIns-3-P and mediates membrane binding; SNAP-25 homolog	1	0	0	1	0.571428571	0.928571429	1	0.4375
2054_OG5_129094_4 - EUKARYOTES_YMR137C	YMR137C	PSO2 - Nuclease required for a post-incision step in the repair of DNA single and double-strand breaks that result from interstrand crosslinks produced by a variety of mono- and bi-functional psoralen derivatives; induced by UV-irradiation	1	0	0	1	0.571428571	0.928571429	1	0.375
2055_OG5_128059_4 - EUKARYOTES_YOR307C	YOR307C	SLY41 - Protein involved in ER-to-Golgi transport	1	0	0	1	0.619047619	0.928571429	0.95	0.3125
2056_OG5_128549_4 - EUKARYOTES_YCR090C	YCR090C	YCR090C - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YCR090C is not an essential gene	1	0	0	1	0.666666667	0.928571429	0.9	0.875
2057_OG5_128109_4 - EUKARYOTES_YPL189W	YPL189W	GUP2 - Probable membrane protein with a possible role in proton symport of glycerol; member of the MBOAT family of putative membrane-bound O-acyltransferases; Gup1p homolog	1	0	0	0.875	0.619047619	1	1	0.1875
2058_OG5_128109_4 - EUKARYOTES_YGL084C	YGL084C	GUP1 - Plasma membrane protein involved in remodeling GPI anchors; member of the MBOAT family of putative membrane-bound O-acyltransferases; proposed to be involved in glycerol transport	1	0	0	0.875	0.619047619	1	1	0.1875
2059_OG5_129063_4 - EUKARYOTES_YKL058W	YKL058W	"TOA2 - TFIIA small subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to smallest subunit of human and Drosophila TFIIA"	1	0	0	0.875	0.761904762	0.857142857	1	0.1875
2060_OG5_129750_4 - EUKARYOTES_YGR187C	YGR187C	HGH1 - Nonessential protein of unknown function; predicted to be involved in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; similar to mammalian BRP16 (Brain protein 16)	1	0	0	0.875	0.761904762	0.857142857	1	0.1875
2061_OG5_129684_4 - EUKARYOTES_YPL215W	YPL215W	CBP3 - Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex	1	0	0.055555556	1	0.857142857	0.785714286	0.85	0.125
2062_OG5_128882_4 - EUKARYOTES_YJR122W	YJR122W	IBA57 - Mitochondrial matrix protein involved in the incorporation of iron-sulfur clusters into mitochondrial aconitase-type proteins; activates the radical-SAM family members Bio2p and Lip5p; interacts with Ccr4p in the two-hybrid system	1	0	0.194444444	0.875	0.80952381	0.857142857	0.95	0.375
2063_OG5_128104_4 - EUKARYOTES_YER143W	YER143W	"DDI1 - DNA damage-inducible v-SNARE binding protein with a role in suppression of protein secretion; may play a role in S-phase checkpoint control; has ubiquitin-associated (UBA), ubiquitin-like (UBL), and retroviral-like proteinase (RVP) domains"	1	0	0	0.875	0.666666667	1	0.95	0.875
2064_OG5_129549_4 - EUKARYOTES_YBL097W	YBL097W	BRN1 - Subunit of the condensin complex; required for chromosome condensation and for clustering of tRNA genes at the nucleolus; may influence multiple aspects of chromosome transmission	1	0	0	0.875	0.666666667	1	0.95	0.125
2065_OG5_129870_4 - EUKARYOTES_YLR097C	YLR097C	"HRT3 - Putative SCF-ubiquitin ligase F-box protein, based on both genetic and physical interactions and sequence similarity; identified in association with Cdc53p, Skp1p and Ubi4 in large and small-scale studies"	1	0	0	0.875	0.666666667	1	0.95	0.125
2066_OG5_129070_4 - EUKARYOTES_YER146W	YER146W	"LSM5 - Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA"	1	0.125	0	0.875	0.857142857	0.857142857	0.9	0.5625
2067_OG5_129130_4 - EUKARYOTES_YGR036C	YGR036C	"CAX4 - Dolichyl pyrophosphate (Dol-P-P) phosphatase with a luminally oriented active site in the ER, cleaves the anhydride linkage in Dol-P-P, required for Dol-P-P-linked oligosaccharide intermediate synthesis and protein N-glycosylation"	1	0	0	0.875	0.714285714	1	0.9	0.4375
2068_OG5_129041_4 - EUKARYOTES_YJL002C	YJL002C	"OST1 - Alpha subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins"	1	0	0	0.75	0.80952381	0.928571429	1	0.375
2069_OG5_129184_4 - EUKARYOTES_YOR164C	YOR164C	GET4 - Protein with a role in insertion of tail-anchored proteins into the ER membrane; forms a complex with Mdy2p; highly conserved across species and homologous to human gene C7orf20	1	0	0	0.75	0.80952381	0.928571429	1	0.5
2070_OG5_129586_4 - EUKARYOTES_YPL149W	YPL149W	ATG5 - Conserved protein involved in autophagy and the Cvt pathway; undergoes conjugation with Atg12p to form a complex involved in Atg8p lipidation; conjugated Atg12p also forms a complex with Atg16p that is essential for autophagosome formation	1	0	0	0.75	0.80952381	0.928571429	1	0.125
2071_OG5_129239_4 - EUKARYOTES_YJR010C-A	YJR010C-A	"SPC1 - Subunit of the signal peptidase complex (SPC), which cleaves the signal sequence from proteins targeted to the endoplasmic reticulum (ER), homolog of the SPC12 subunit of mammalian signal peptidase complex"	1	0	0	1	0.857142857	0.928571429	0.7	0.4375
2072_OG5_129793_4 - EUKARYOTES_YML055W	YML055W	"SPC2 - Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC25"	1	0	0	0.875	0.80952381	1	0.8	0.125
2073_OG5_127881_4 - EUKARYOTES_YMR292W	YMR292W	GOT1 - Homodimeric protein that is packaged into COPII vesicles and cycles between the ER and Golgi; involved in secretory transport but not directly required for aspects of transport assayed in vitro; may influence membrane composition	1	0	0	0.75	0.904761905	0.928571429	0.9	0.8125
2074_OG5_126950_4 - EUKARYOTES_YIL033C	YIL033C	"BCY1 - Regulatory subunit of the cyclic AMP-dependent protein kinase (PKA), a component of a signaling pathway that controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation"	1	0	0.083333333	0.625	0.857142857	1	1	0.9375
2075_OG5_126558_4 - EUKARYOTES_YKR054C	YKR054C	"DYN1 - Cytoplasmic heavy chain dynein, microtubule motor protein, required for anaphase spindle elongation; involved in spindle assembly, chromosome movement, and spindle orientation during cell division, targeted to microtubule tips by Pac1p"	1	0	0	0.625	0.857142857	1	1	0.875
2076_OG5_126748_4 - EUKARYOTES_YPL203W	YPL203W	TPK2 - cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk3p; localizes to P-bodies during stationary phase	1	0	0	0.625	0.857142857	1	1	0.9375
2077_OG5_126748_4 - EUKARYOTES_YKL166C	YKL166C	TPK3 - cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk2p; localizes to P-bodies during stationary phase	1	0	0	0.625	0.857142857	1	1	0.9375
2078_OG5_127000_4 - EUKARYOTES_YKL146W	YKL146W	"AVT3 - Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters"	1	0	0	0.625	0.857142857	1	1	0.5
2079_OG5_127000_4 - EUKARYOTES_YNL101W	YNL101W	"AVT4 - Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters"	1	0	0	0.625	0.857142857	1	1	0.5
2080_OG5_128565_4 - EUKARYOTES_YBR170C	YBR170C	NPL4 - Ubiquitin-binding protein involved in protein degradation; Cdc48p-Npl4p-Ufd1p complex participates in ER-associated degradation (ERAD) while Cdc48p-Npl4p-Vms1p complex participates in mitochondria-associated degradation (MAD)	1	0	0	0.625	0.857142857	1	1	0.6875
2081_OG5_129200_4 - EUKARYOTES_YIL065C	YIL065C	FIS1 - Protein involved in mitochondrial membrane fission and peroxisome abundance; required for localization of Dnm1p and Mdv1p during mitochondrial division; mediates ethanol-induced apoptosis and ethanol-induced mitochondrial fragmentation	1	0	0	1	0.761904762	0.714285714	1	0.3125
2082_OG5_129050_4 - EUKARYOTES_YLL009C	YLL009C	COX17 - Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs	1	0	0	1	0.714285714	0.857142857	0.9	0.5
2083_OG5_127446_4 - EUKARYOTES_YGL220W	YGL220W	"FRA2 - Protein involved in negative regulation of transcription of iron regulon; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; null mutant fails to repress iron regulon and is sensitive to nickel"	1	0	0.055555556	0.875	0.80952381	0.785714286	1	0.6875
2084_OG5_127446_4 - EUKARYOTES_YAL046C	YAL046C	AIM1 - Protein involved in mitochondrial function or organization; null mutant displays elevated frequency of mitochondrial genome loss	1	0	0.055555556	0.875	0.80952381	0.785714286	1	0.6875
2085_OG5_127280_4 - EUKARYOTES_YGL216W	YGL216W	KIP3 - Kinesin-related motor protein involved in mitotic spindle positioning	1	0	0.027777778	0.875	0.666666667	0.928571429	1	0.625
2086_OG5_128606_4 - EUKARYOTES_YJL140W	YJL140W	RPB4 - RNA polymerase II subunit B32; forms two subunit dissociable complex with Rpb7p; involved in recruitment of 3'-end processing factors to transcribing RNA polymerase II complex and in export of mRNA to cytoplasm under stress conditions	1	0	0	0.875	0.666666667	0.928571429	1	0.75
2087_OG5_129552_4 - EUKARYOTES_YJR129C	YJR129C	YJR129C - Putative protein of unknown function; predicted S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	1	0	0	0.875	0.666666667	0.928571429	1	0.125
2088_OG5_129888_4 - EUKARYOTES_YNL035C	YNL035C	YNL035C - Putative protein of unknown function with similarity to proteins containing WD-40 domains; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YNL035C is not an essential gene	1	0	0	0.875	0.666666667	0.928571429	1	0.125
2089_OG5_129197_4 - EUKARYOTES_YBR104W	YBR104W	"YMC2 - Mitochondrial protein, putative inner membrane transporter with a role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; has similarity with Ymc1p"	1	0	0	0.875	0.714285714	0.928571429	0.95	0.0625
2090_OG5_129197_4 - EUKARYOTES_YPR058W	YPR058W	"YMC1 - Mitochondrial protein, putative inner membrane transporter with a role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; has similarity with Ymc2p"	1	0	0	0.875	0.714285714	0.928571429	0.95	0.0625
2091_OG5_129963_4 - EUKARYOTES_YHR188C	YHR188C	GPI16 - Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-Tp homolog	1	0	0	0.875	0.714285714	0.928571429	0.95	0.25
2092_OG5_128999_4 - EUKARYOTES_YLR016C	YLR016C	"PML1 - Subunit of the RES complex, which is required for nuclear retention of unspliced pre-mRNAs; acts in the same pathway as Pml39p and Mlp1p"	1	0	0.027777778	1	0.80952381	0.857142857	0.8	0.625
2093_OG5_129297_4 - EUKARYOTES_YIL049W	YIL049W	"DFG10 - Probable polyprenol reductase that catalyzes conversion of polyprenol to dolichol, the precursor for N-glycosylation; involved in filamentous growth; mutations in human ortholog SRD5A3 confer CDG (Congenital Disorders of Glycosylation)"	1	0	0	1	0.666666667	1	0.8	0.3125
2094_OG5_129702_4 - EUKARYOTES_YOL135C	YOL135C	MED7 - Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation	1	0	0	1	0.80952381	0.857142857	0.8	0.25
2095_OG5_129162_4 - EUKARYOTES_YDR386W	YDR386W	"MUS81 - Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in DNA repair, replication fork stability, and joint molecule formation/resolution during meiotic recombination; helix-hairpin-helix protein"	1	0	0	0.875	0.761904762	0.928571429	0.9	0.25
2096_OG5_130031_4 - EUKARYOTES_YOR002W	YOR002W	"ALG6 - Alpha 1,3 glucosyltransferase, involved in transfer of oligosaccharides from dolichyl pyrophosphate to asparagine residues of proteins during N-linked protein glycosylation; mutations in human ortholog are associated with disease"	1	0	0	0.875	0.761904762	0.928571429	0.9	0.1875
2097_OG5_128685_4 - EUKARYOTES_YMR009W	YMR009W	ADI1 - Acireductone dioxygenease involved in the methionine salvage pathway; ortholog of human MTCBP-1; transcribed with YMR010W and regulated post-transcriptionally by RNase III (Rnt1p) cleavage; ADI1 mRNA is induced in heat shock conditions	1	0	0.111111111	0.75	0.714285714	1	1	0.1875
2098_OG5_126743_4 - EUKARYOTES_YGL253W	YGL253W	HXK2 - Hexokinase isoenzyme 2 that catalyzes phosphorylation of glucose in the cytosol; predominant hexokinase during growth on glucose; functions in the nucleus to repress expression of HXK1 and GLK1 and to induce expression of its own gene	1	0	0.027777778	0.75	0.714285714	1	1	0.75
2099_OG5_126743_4 - EUKARYOTES_YDR516C	YDR516C	EMI2 - Non-essential protein of unknown function required for transcriptional induction of the early meiotic-specific transcription factor IME1; required for sporulation; expression is regulated by glucose-repression transcription factors Mig1/2p	1	0	0.027777778	0.75	0.714285714	1	1	0.75
2100_OG5_126743_4 - EUKARYOTES_YFR053C	YFR053C	"HXK1 - Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p"	1	0	0.027777778	0.75	0.714285714	1	1	0.75
2101_OG5_126743_4 - EUKARYOTES_YCL040W	YCL040W	"GLK1 - Glucokinase, catalyzes the phosphorylation of glucose at C6 in the first irreversible step of glucose metabolism; one of three glucose phosphorylating enzymes; expression regulated by non-fermentable carbon sources"	1	0	0.027777778	0.75	0.714285714	1	1	0.75
2102_OG5_128847_4 - EUKARYOTES_YHR175W	YHR175W	"CTR2 - Putative low-affinity copper transporter of the vacuolar membrane; mutation confers resistance to toxic copper concentrations, while overexpression confers resistance to copper starvation"	1	0	0	0.75	0.714285714	1	1	0.0625
2103_OG5_128847_4 - EUKARYOTES_YLR411W	YLR411W	"CTR3 - High-affinity copper transporter of the plasma membrane, acts as a trimer; gene is disrupted by a Ty2 transposon insertion in many laboratory strains of S. cerevisiae"	1	0	0	0.75	0.714285714	1	1	0.0625
2104_OG5_129494_4 - EUKARYOTES_YDL065C	YDL065C	"PEX19 - Chaperone and import receptor for newly-synthesized class I peroxisomal membrane proteins (PMPs), binds PMPs in the cytoplasm and delivers them to the peroxisome for subsequent insertion into the peroxisomal membrane"	1	0	0	0.75	0.857142857	0.857142857	1	0.0625
2105_OG5_129587_4 - EUKARYOTES_YAL043C	YAL043C	"PTA1 - Subunit of holo-CPF, a multiprotein complex and functional homolog of mammalian CPSF, required for the cleavage and polyadenylation of mRNA and snoRNA 3' ends; involved in pre-tRNA processing; binds to the phosphorylated CTD of RNAPII"	1	0	0	0.75	0.857142857	0.857142857	1	0.1875
2106_OG5_129711_4 - EUKARYOTES_YPR162C	YPR162C	"ORC4 - Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing"	1	0	0	0.75	0.714285714	1	1	0.375
2107_OG5_129934_4 - EUKARYOTES_YPL125W	YPL125W	KAP120 - Karyopherin responsible for the nuclear import of ribosome maturation factor Rfp1p	1	0	0	0.75	0.714285714	1	1	0.0625
2108_OG5_127882_4 - EUKARYOTES_YGL183C	YGL183C	"MND1 - Protein required for recombination and meiotic nuclear division; forms a complex with Hop2p, which is involved in chromosome pairing and repair of meiotic double-strand breaks"	1	0	0	1	0.714285714	1	0.75	0.8125
2109_OG5_129892_4 - EUKARYOTES_YAL033W	YAL033W	"POP5 - Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs"	1	0	0	0.875	0.80952381	0.928571429	0.85	0.1875
2110_OG5_129513_4 - EUKARYOTES_YDL003W	YDL003W	MCD1 - Essential subunit of the cohesin complex required for sister chromatid cohesion in mitosis and meiosis; apoptosis induces cleavage and translocation of a C-terminal fragment to mitochondria; expression peaks in S phase	1	0.0625	0	0.75	0.761904762	1	0.95	0.1875
2111_OG5_129105_4 - EUKARYOTES_YGL237C	YGL237C	"HAP2 - Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding"	1	0	0	0.75	0.761904762	1	0.95	0.25
2112_OG5_129538_4 - EUKARYOTES_YNL045W	YNL045W	"LAP2 - Leucyl aminopeptidase yscIV (leukotriene A4 hydrolase) with epoxide hydrolase activity, metalloenzyme containing one zinc atom; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus"	1	0	0	0.75	0.761904762	1	0.95	0.125
2113_OG5_129159_4 - EUKARYOTES_YER063W	YER063W	"THO1 - Conserved nuclear RNA-binding protein; specifically binds to transcribed chromatin in a THO- and RNA-dependent manner, genetically interacts with shuttling hnRNP NAB2; overproduction suppresses transcriptional defect caused by hpr1 mutation"	1	0	0	0.875	0.857142857	0.928571429	0.8	0.5
2114_OG5_128797_4 - EUKARYOTES_YBR155W	YBR155W	"CNS1 - TPR-containing co-chaperone; binds both Hsp82p (Hsp90) and Ssa1p (Hsp70) and stimulates the ATPase activity of SSA1, ts mutants reduce Hsp82p function while over expression suppresses the phenotypes of an HSP82 ts allele and a cpr7 deletion"	1	0	0	0.75	0.952380952	0.857142857	0.9	0.625
2115_OG5_128635_4 - EUKARYOTES_YHR090C	YHR090C	YNG2 - Subunit of the NuA4 histone acetyltransferase complex that acetylates histone H4 and H2A; has similarity to the human tumor suppressor ING1 and its isoforms ING4 and ING5	1	0	0	1	0.80952381	1	0.65	0.3125
2116_OG5_127580_4 - EUKARYOTES_YKL081W	YKL081W	"TEF4 - Gamma subunit of translational elongation factor eEF1B, stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing eEF1A (Tef1p/Tef2p) from the ribosomal complex"	1	0	0	0.625	0.904761905	0.928571429	1	0.75
2117_OG5_127580_4 - EUKARYOTES_YPL048W	YPL048W	CAM1 - Nuclear protein required for transcription of MXR1; binds the MXR1 promoter in the presence of other nuclear factors; binds calcium and phospholipids; has similarity to translational cofactor EF-1 gamma	1	0	0	0.625	0.904761905	0.928571429	1	0.75
2118_OG5_128690_4 - EUKARYOTES_YOR265W	YOR265W	"RBL2 - Protein involved in microtubule morphogenesis, required for protection from excess free beta-tubulin; proposed to be involved the folding of beta-tubulin; similar to mouse beta-tubulin cofactor A"	1	0	0	0.875	0.904761905	0.928571429	0.75	0.625
2119_OG5_126812_4 - EUKARYOTES_YBR159W	YBR159W	"IFA38 - Microsomal beta-keto-reductase; contains oleate response element (ORE) sequence in the promoter region; mutants exhibit reduced VLCFA synthesis, accumulate high levels of dihydrosphingosine, phytosphingosine and medium-chain ceramides"	1	0	0.194444444	0.5	0.952380952	1	1	0.6875
2120_OG5_127396_4 - EUKARYOTES_YMR001C	YMR001C	"CDC5 - Polo-like kinase with multiple functions in mitosis and cytokinesis through substrate phosphorylation, also functions in adaptation to DNA damage during meiosis; has similarity to Xenopus Plx1 and S. pombe Plo1p; possible Cdc28p substrate"	1	0	0	0.5	0.952380952	1	1	0.5625
2121_OG5_128611_4 - EUKARYOTES_YLR306W	YLR306W	"UBC12 - Enzyme that mediates the conjugation of Rub1p, a ubiquitin-like protein, to other proteins; related to E2 ubiquitin-conjugating enzymes"	1	0	0	1	0.80952381	0.642857143	1	0.625
2122_OG5_129605_4 - EUKARYOTES_YMR026C	YMR026C	"PEX12 - C3HC4-type RING-finger peroxin and E3 ubiquitin ligase, required for peroxisome biogenesis and peroxisomal matrix protein import; forms translocation subcomplex with Pex2p and Pex10p; mutations in human homolog cause peroxisomal disorder"	1	0	0	1	0.714285714	0.785714286	0.95	0.25
2123_OG5_129729_4 - EUKARYOTES_YJL210W	YJL210W	"PEX2 - RING-finger peroxin and E3 ubiquitin ligase, peroxisomal membrane protein with a C-terminal zinc-binding RING domain, forms translocation subcomplex with Pex10p and Pex12p which functions in peroxisomal matrix protein import"	1	0	0	1	0.571428571	0.928571429	0.95	0.1875
2124_OG5_128425_4 - EUKARYOTES_YNL113W	YNL113W	"RPC19 - RNA polymerase subunit AC19, common to RNA polymerases I and III"	1	0.0625	0	0.875	0.857142857	0.714285714	1	0.75
2125_OG5_127737_4 - EUKARYOTES_YOR122C	YOR122C	"PFY1 - Profilin, binds actin, phosphatidylinositol 4,5-bisphosphate, and polyproline regions; involved in cytoskeleton organization; required for normal timing of actin polymerization in response to thermal stress"	1	0	0	0.875	0.857142857	0.714285714	1	0.1875
2126_OG5_128569_4 - EUKARYOTES_YNL310C	YNL310C	ZIM17 - Heat shock protein with a zinc finger motif; essential for protein import into mitochondria; may act with Pam18p to facilitate recognition and folding of imported proteins by Ssc1p (mtHSP70) in the mitochondrial matrix	1	0	0	0.875	0.714285714	0.857142857	1	0.625
2127_OG5_128630_4 - EUKARYOTES_YKL013C	YKL013C	"ARC19 - Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches"	1	0	0	0.875	0.857142857	0.714285714	1	0.375
2128_OG5_129093_4 - EUKARYOTES_YER110C	YER110C	"KAP123 - Karyopherin beta, mediates nuclear import of ribosomal proteins prior to assembly into ribosomes and import of histones H3 and H4; localizes to the nuclear pore, nucleus, and cytoplasm; exhibits genetic interactions with RAI1"	1	0	0	0.875	0.714285714	0.857142857	1	0.3125
2129_OG5_129634_4 - EUKARYOTES_YDR068W	YDR068W	"DOS2 - Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm"	1	0	0	0.875	0.619047619	1	0.95	0.0625
2130_OG5_128490_4 - EUKARYOTES_YFL017W-A	YFL017W-A	"SMX2 - Core Sm protein Sm G; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx3p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm G"	1	0.0625	0	1	0.857142857	0.785714286	0.8	0.75
2131_OG5_129096_4 - EUKARYOTES_YPR056W	YPR056W	"TFB4 - Subunit of TFIIH complex, involved in transcription initiation, similar to 34 kDa subunit of human TFIIH; interacts with Ssl1p"	1	0	0	1	0.857142857	0.785714286	0.8	0.625
2132_OG5_130446_4 - EUKARYOTES_YGR033C	YGR033C	TIM21 - Nonessential subunit of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); interacts with the Translocase of the Outer Mitochondrial membrane (TOM complex) and with respiratory enzymes; may regulate TIM23 complex activity	1	0	0	1	0.714285714	0.928571429	0.8	0.0625
2133_OG5_127199_4 - EUKARYOTES_YFR032C-A	YFR032C-A	"RPL29 - Protein component of the large (60S) ribosomal subunit, has similarity to rat L29 ribosomal protein; not essential for translation, but required for proper joining of the large and small ribosomal subunits and for normal translation rate"	1	0	0	0.875	0.80952381	0.857142857	0.9	0.875
2134_OG5_129230_4 - EUKARYOTES_YBL082C	YBL082C	"ALG3 - Dolichol-P-Man dependent alpha(1-3) mannosyltransferase, involved in the synthesis of dolichol-linked oligosaccharide donor for N-linked glycosylation of proteins"	1	0	0	0.75	0.761904762	0.928571429	1	0.3125
2135_OG5_129124_4 - EUKARYOTES_YOR103C	YOR103C	"OST2 - Epsilon subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins"	1	0	0	0.75	0.80952381	0.928571429	0.95	0.4375
2136_OG5_129165_4 - EUKARYOTES_YNR030W	YNR030W	"ALG12 - Alpha-1,6-mannosyltransferase localized to the ER; responsible for the addition of the alpha-1,6 mannose to dolichol-linked Man7GlcNAc2, acts in the dolichol pathway for N-glycosylation"	1	0	0	0.75	0.80952381	0.928571429	0.95	0.25
2137_OG5_129372_4 - EUKARYOTES_YMR106C	YMR106C	"YKU80 - Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair"	1	0	0	0.75	0.80952381	0.928571429	0.95	0.3125
2138_OG5_129756_4 - EUKARYOTES_YJL004C	YJL004C	SYS1 - Integral membrane protein of the Golgi required for targeting of the Arf-like GTPase Arl3p to the Golgi; multicopy suppressor of ypt6 null mutation	1	0	0	0.75	0.80952381	0.928571429	0.95	0.3125
2139_OG5_127676_4 - EUKARYOTES_YDR430C	YDR430C	"CYM1 - Lysine-specific metalloprotease of the mitochondrial intermembrane space, member of the pitrilysin family; degrades proteins and presequence peptides cleaved from imported proteins; required for normal mitochondrial morphology"	1	0	0.138888889	0.875	0.761904762	1	0.8	0.8125
2140_OG5_130012_4 - EUKARYOTES_YBL074C	YBL074C	"AAR2 - Component of the U5 snRNP, required for splicing of U3 precursors; originally described as a splicing factor specifically required for splicing pre-mRNA of the MATa1 cistron"	1	0	0	0.875	0.761904762	1	0.8	0.125
2141_OG5_127568_4 - EUKARYOTES_YDR334W	YDR334W	"SWR1 - Swi2/Snf2-related ATPase that is the structural component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A"	1	0	0	0.625	0.80952381	1	1	0.75
2142_OG5_128682_4 - EUKARYOTES_YGL233W	YGL233W	"SEC15 - Essential 113kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which mediates polarized targeting of vesicles to active sites of exocytosis; Sec15p associates with Sec4p and vesicles"	1	0	0	0.625	0.80952381	1	1	0.125
2143_OG5_128753_4 - EUKARYOTES_YKR003W	YKR003W	"OSH6 - Member of an oxysterol-binding protein family with overlapping, redundant functions in sterol metabolism and which collectively perform a function essential for viability; GFP-fusion protein localizes to the cell periphery"	1	0	0	0.625	0.80952381	1	1	0.125
2144_OG5_128753_4 - EUKARYOTES_YHR001W	YHR001W	"OSH7 - Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability"	1	0	0	0.625	0.80952381	1	1	0.125
2145_OG5_129502_4 - EUKARYOTES_YHR058C	YHR058C	MED6 - Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation	1	0	0	0.625	0.80952381	1	1	0.25
2146_OG5_127674_4 - EUKARYOTES_YER068W	YER068W	"MOT2 - Subunit of the CCR4-NOT complex, which has roles in transcription regulation, mRNA degradation, and post-transcriptional modifications; with Ubc4p, ubiquitinates nascent polypeptide-associated complex subunits and histone demethyase Jhd2p"	1	0	0	0.625	0.857142857	1	0.95	0.75
2147_OG5_127973_4 - EUKARYOTES_YOR212W	YOR212W	"STE4 - G protein beta subunit, forms a dimer with Ste18p to activate the mating signaling pathway, forms a heterotrimer with Gpa1p and Ste18p to dampen signaling; may recruit Rho1p to the polarized growth site during mating; contains WD40 repeats"	1	0	0	0.625	0.904761905	1	0.9	0.125
2148_OG5_129059_4 - EUKARYOTES_YLR216C	YLR216C	"CPR6 - Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity"	1	0	0	1	0.619047619	0.857142857	0.95	0.3125
2149_OG5_129854_4 - EUKARYOTES_YDR049W	YDR049W	"VMS1 - Component of a Cdc48p-complex involved in protein quality control; exhibits cytosolic and ER-membrane localization, with Cdc48p, during normal growth, and contributes to ER-associated degradation (ERAD) of specific substrates at a step after their ubiquitination; forms a mitochondrially-associated complex with Cdc48p and Npl4p under oxidative stress that is required for ubiquitin-mediated mitochondria-associated protein degradation (MAD); conserved in C. elegans and humans"	1	0	0.027777778	0.875	0.619047619	0.928571429	1	0.125
2150_OG5_129606_4 - EUKARYOTES_YDR265W	YDR265W	"PEX10 - Peroxisomal membrane E3 ubiquitin ligase, required for for Ubc4p-dependent Pex5p ubiquitination and peroxisomal matrix protein import; contains zinc-binding RING domain; mutations in human homolog cause various peroxisomal disorders"	1	0	0	0.875	0.619047619	0.928571429	1	0.3125
2151_OG5_128993_4 - EUKARYOTES_YIL144W	YIL144W	"TID3 - Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); conserved coiled-coil protein involved in chromosome segregation, spindle checkpoint activity, kinetochore assembly and clustering"	1	0	0.027777778	0.875	0.666666667	0.928571429	0.95	0.6875
2152_OG5_129324_4 - EUKARYOTES_YCR044C	YCR044C	"PER1 - Protein of the endoplasmic reticulum, required for GPI-phospholipase A2 activity that remodels the GPI anchor as a prerequisite for association of GPI-anchored proteins with lipid rafts; functionally complemented by human ortholog PERLD1"	1	0	0	0.875	0.666666667	0.928571429	0.95	0.1875
2153_OG5_129994_4 - EUKARYOTES_YDR412W	YDR412W	RRP17 - Component of the pre-60S pre-ribosomal particle; required for cell viability under standard (aerobic) conditions but not under anaerobic conditions; exonuclease required for 5&#8242; end processing of pre-60S ribosomal RNA	1	0	0	0.875	0.666666667	0.928571429	0.95	0.1875
2154_OG5_128788_4 - EUKARYOTES_YNL138W-A	YNL138W-A	"YSF3 - Component of the SF3b subcomplex of the U2 snRNP, essential protein required for for splicing and for assembly of SF3b"	1	0	0	1	0.761904762	0.857142857	0.8	0.8125
2155_OG5_127239_4 - EUKARYOTES_YCR037C	YCR037C	"PHO87 - Low-affinity inorganic phosphate (Pi) transporter, involved in activation of PHO pathway; expression is independent of Pi concentration and Pho4p activity; contains 12 membrane-spanning segments"	1	0.125	0.194444444	0.75	0.666666667	1	1	0.5625
2156_OG5_127239_4 - EUKARYOTES_YNR013C	YNR013C	"PHO91 - Low-affinity phosphate transporter of the vacuolar membrane; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth"	1	0.125	0.194444444	0.75	0.666666667	1	1	0.5625
2157_OG5_127239_4 - EUKARYOTES_YJL198W	YJL198W	"PHO90 - Low-affinity phosphate transporter; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth"	1	0.125	0.194444444	0.75	0.666666667	1	1	0.5625
2158_OG5_129044_4 - EUKARYOTES_YGR024C	YGR024C	"THG1 - tRNAHis guanylyltransferase, adds a guanosine residue to the 5' end of tRNAHis after transcription and RNase P cleavage; couples nuclear division and migration to cell budding and cytokinesis; essential enzyme conserved among eukaryotes"	1	0.125	0	0.75	0.666666667	1	1	0.4375
2159_OG5_129190_4 - EUKARYOTES_YOR085W	YOR085W	"OST3 - Gamma subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins"	1	0	0	0.75	0.666666667	1	1	0.125
2160_OG5_129274_4 - EUKARYOTES_YER151C	YER151C	UBP3 - Ubiquitin-specific protease that interacts with Bre5p to co-regulate anterograde and retrograde transport between the ER and Golgi; inhibitor of gene silencing; cleaves ubiquitin fusions but not polyubiquitin; also has mRNA binding activity	1	0	0	0.75	0.666666667	1	1	0.3125
2161_OG5_129385_4 - EUKARYOTES_YDR324C	YDR324C	UTP4 - Subunit of U3-containing 90S preribosome and Small Subunit (SSU) processome complexes involved in production of 18S rRNA and assembly of small ribosomal subunit; member of t-Utp subcomplex involved with transcription of 35S rRNA transcript	1	0	0	0.75	0.666666667	1	1	0.5
2162_OG5_128624_4 - EUKARYOTES_YJR135W-A	YJR135W-A	"TIM8 - Mitochondrial intermembrane space protein, forms a complex with Tim13p that delivers a subset of hydrophobic proteins to the TIM22 complex for inner membrane insertion; homolog of human TIMM8A, implicated in Mohr-Tranebjaerg syndrome"	1	0	0	0.875	0.761904762	0.928571429	0.85	0.3125
2163_OG5_128383_4 - EUKARYOTES_YIL008W	YIL008W	URM1 - Ubiquitin-like protein involved in thiolation of cytoplasmic tRNAs; receives sulfur from the E1-like enzyme Uba4p and transfers it to tRNA; also functions as a protein tag with roles in nutrient sensing and oxidative stress response	1	0.0625	0	0.75	0.857142857	0.857142857	0.95	0.75
2164_OG5_129029_4 - EUKARYOTES_YOR130C	YOR130C	"ORT1 - Ornithine transporter of the mitochondrial inner membrane, exports ornithine from mitochondria as part of arginine biosynthesis; human ortholog is associated with hyperammonaemia-hyperornithinaemia-homocitrullinuria (HHH) syndrome"	1	0	0	0.75	0.714285714	1	0.95	0.25
2165_OG5_129781_4 - EUKARYOTES_YFL007W	YFL007W	"BLM10 - Proteasome activator subunit; found in association with core particles, with and without the 19S regulatory particle; required for resistance to bleomycin, may be involved in protecting against oxidative damage; similar to mammalian PA200"	1	0	0	0.75	0.714285714	1	0.95	0.0625
2166_OG5_128200_4 - EUKARYOTES_YNR019W	YNR019W	"ARE2 - Acyl-CoA:sterol acyltransferase, isozyme of Are1p; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the presence of oxygen"	1	0	0	0.625	0.857142857	0.928571429	1	0.625
2167_OG5_128883_4 - EUKARYOTES_YGL094C	YGL094C	"PAN2 - Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes"	1	0	0	0.625	0.857142857	0.928571429	1	0.5
2168_OG5_126861_4 - EUKARYOTES_YKL140W	YKL140W	"TGL1 - Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes"	1	0	0	0.75	0.80952381	1	0.85	0.125
2169_OG5_129040_4 - EUKARYOTES_YLR056W	YLR056W	"ERG3 - C-5 sterol desaturase, catalyzes the introduction of a C-5(6) double bond into episterol, a precursor in ergosterol biosynthesis; mutants are viable, but cannot grow on non-fermentable carbon sources"	1	0	0	1	0.476190476	0.928571429	1	0.25
2170_OG5_128203_4 - EUKARYOTES_YBR220C	YBR220C	YBR220C - Putative protein of unknown function; YBR220C is not an essential gene	1	0	0	0.5	0.904761905	1	1	0.5
2171_OG5_128456_4 - EUKARYOTES_YLR430W	YLR430W	SEN1 - Presumed helicase required for RNA polymerase II transcription termination and processing of RNAs; homolog of Senataxin which causes Ataxia-Oculomotor Apraxia 2 and a dominant form of amyotrophic lateral sclerosis	1	0	0	1	0.619047619	0.785714286	1	0.4375
2172_OG5_128362_4 - EUKARYOTES_YLR305C	YLR305C	"STT4 - Phosphatidylinositol-4-kinase that functions in the Pkc1p protein kinase pathway; required for normal vacuole morphology, cell wall integrity, and actin cytoskeleton organization"	1	0	0	0.5	0.952380952	1	0.95	0.4375
2173_OG5_128316_4 - EUKARYOTES_YJL153C	YJL153C	"INO1 - Inositol-3-phosphate synthase, involved in synthesis of inositol phosphates and inositol-containing phospholipids; transcription is coregulated with other phospholipid biosynthetic genes by Ino2p and Ino4p, which bind the UASINO DNA element"	1	0.0625	0	1	0.857142857	0.642857143	0.9	0.4375
2174_OG5_129018_4 - EUKARYOTES_YKL173W	YKL173W	SNU114 - GTPase component of U5 snRNP involved in mRNA splicing via spliceosome; binds directly to U5 snRNA; proposed to be involved in conformational changes of the spliceosome; similarity to ribosomal translocation factor EF-2	1	0	0	1	0.857142857	0.642857143	0.9	0.5
2175_OG5_129547_4 - EUKARYOTES_YKL191W	YKL191W	"DPH2 - Protein required, along with Dph1p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph1p and Kti11p"	1	0	0	0.875	0.80952381	0.714285714	1	0.25
2176_OG5_128377_4 - EUKARYOTES_YJR085C	YJR085C	"YJR085C - Putative protein of unknown function; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"	1	0	0	0.875	0.714285714	0.857142857	0.95	0.25
2177_OG5_128748_4 - EUKARYOTES_YJR035W	YJR035W	RAD26 - Protein involved in transcription-coupled nucleotide excision repair of UV-induced DNA lesions; recruitment to DNA lesions is dependent on an elongating RNA polymerase II; homolog of human CSB protein	1	0	0.055555556	1	0.666666667	0.928571429	0.8	0.8125
2178_OG5_128224_4 - EUKARYOTES_YOR159C	YOR159C	"SME1 - Core Sm protein Sm E; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm E"	1	0.0625	0	0.875	0.952380952	0.714285714	0.85	0.75
2179_OG5_129585_4 - EUKARYOTES_YOL003C	YOL003C	"PFA4 - Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases"	1	0	0	0.75	0.761904762	0.928571429	0.95	0.125
2180_OG5_128762_4 - EUKARYOTES_YJR001W	YJR001W	"AVT1 - Vacuolar transporter, imports large neutral amino acids into the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters"	1	0	0	0.875	0.714285714	1	0.8	0.0625
2181_OG5_128955_4 - EUKARYOTES_YBL088C	YBL088C	TEL1 - Protein kinase primarily involved in telomere length regulation; contributes to cell cycle checkpoint control in response to DNA damage; functionally redundant with Mec1p; homolog of human ataxia telangiectasia (ATM) gene	1	0	0	0.625	0.761904762	1	1	0.5
2182_OG5_129163_4 - EUKARYOTES_YGL083W	YGL083W	"SCY1 - Putative kinase, suppressor of GTPase mutant, similar to bovine rhodopsin kinase"	1	0	0	0.625	0.761904762	1	1	0.375
2183_OG5_129596_4 - EUKARYOTES_YNL297C	YNL297C	"MON2 - Peripheral membrane protein with a role in endocytosis and vacuole integrity, interacts with Arl1p and localizes to the endosome; member of the Sec7p family of proteins"	1	0	0	0.625	0.761904762	1	1	0.125
2184_OG5_129826_4 - EUKARYOTES_YNL025C	YNL025C	"SSN8 - Cyclin-like component of the RNA polymerase II holoenzyme, involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression and telomere maintenance"	1	0	0	0.625	0.761904762	1	1	0.125
2185_OG5_126683_4 - EUKARYOTES_YDR497C	YDR497C	"ITR1 - Myo-inositol transporter with strong similarity to the minor myo-inositol transporter Itr2p, member of the sugar transporter superfamily; expression is repressed by inositol and choline via Opi1p and derepressed via Ino2p and Ino4p"	1	0.1875	0.194444444	0.625	0.80952381	1	0.95	0.625
2186_OG5_126683_4 - EUKARYOTES_YOL103W	YOL103W	"ITR2 - Myo-inositol transporter with strong similarity to the major myo-inositol transporter Itr1p, member of the sugar transporter superfamily; expressed constitutively"	1	0.1875	0.194444444	0.625	0.80952381	1	0.95	0.625
2187_OG5_129612_4 - EUKARYOTES_YAL002W	YAL002W	VPS8 - Membrane-associated protein that interacts with Vps21p to facilitate soluble vacuolar protein localization; component of the CORVET complex; required for localization and trafficking of the CPY sorting receptor; contains RING finger motif	1	0	0	0.625	0.80952381	1	0.95	0.125
2188_OG5_130157_4 - EUKARYOTES_YNL119W	YNL119W	NCS2 - Protein required for thiolation of the uridine at the wobble position of Lys(UUU) and Glu(UUC) tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae	1	0	0	0.625	0.80952381	1	0.95	0.0625
2189_OG5_129454_4 - EUKARYOTES_YKR025W	YKR025W	RPC37 - RNA polymerase III subunit C37	1	0	0	0.875	0.857142857	1	0.65	0.375
2190_OG5_127346_4 - EUKARYOTES_YPL268W	YPL268W	"PLC1 - Phospholipase C, hydrolyzes phosphatidylinositol 4,5-biphosphate (PIP2) to generate the signaling molecules inositol 1,4,5-triphosphate (IP3) and 1,2-diacylglycerol (DAG); involved in regulating many cellular processes"	1	0	0	1	0.380952381	1	1	0.5
2191_OG5_130007_4 - EUKARYOTES_YEL013W	YEL013W	"VAC8 - Phosphorylated and palmitoylated vacuolar membrane protein that interacts with Atg13p, required for the cytoplasm-to-vacuole targeting (Cvt) pathway; interacts with Nvj1p to form nucleus-vacuole junctions"	1	0	0	1	0.380952381	1	1	0.125
2192_OG5_129365_4 - EUKARYOTES_YLR215C	YLR215C	CDC123 - Protein involved in nutritional control of the cell cycle; regulates abundance of the translation initiation factor eIF2; ortholog of human D123 protein	1	0	0	0.875	0.619047619	0.928571429	0.95	0.4375
2193_OG5_128289_4 - EUKARYOTES_YOR027W	YOR027W	"STI1 - Hsp90 cochaperone, interacts with the Ssa group of the cytosolic Hsp70 chaperones and activates Ssa1p ATPase activity; interacts with Hsp90 chaperones and inhibits their ATPase activity; homolog of mammalian Hop"	1	0.0625	0.027777778	0.75	0.761904762	0.857142857	1	0.8125
2194_OG5_128556_4 - EUKARYOTES_YKR028W	YKR028W	"SAP190 - Protein that forms a complex with the Sit4p protein phosphatase and is required for its function; member of a family of similar proteins including Sap4p, Sap155p, and Sap185p"	1	0	0	0.75	0.666666667	1	0.95	0.0625
2195_OG5_128556_4 - EUKARYOTES_YJL098W	YJL098W	"SAP185 - Protein that forms a complex with the Sit4p protein phosphatase and is required for its function; member of a family of similar proteins including Sap4p, Sap155p, and Sap190p"	1	0	0	0.75	0.666666667	1	0.95	0.0625
2196_OG5_129326_4 - EUKARYOTES_YLR435W	YLR435W	TSR2 - Protein with a potential role in pre-rRNA processing	1	0	0	0.75	0.80952381	0.857142857	0.95	0.375
2197_OG5_129637_4 - EUKARYOTES_YKL195W	YKL195W	MIA40 - Essential protein of the mitochondrial intermembrane space (IMS); promotes retention of newly imported proteins; may do so by stabilizing client protein folding as part of a disulfide relay system or transferring metal to client proteins	1	0	0	0.75	0.666666667	1	0.95	0
2198_OG5_130094_4 - EUKARYOTES_YGR129W	YGR129W	"SYF2 - Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; isy1 syf2 cells have defective spindles activiating cell cycle arrest"	1	0	0	0.75	0.666666667	1	0.95	0.1875
2199_OG5_129531_4 - EUKARYOTES_YIL023C	YIL023C	"YKE4 - Zinc transporter; localizes to the ER; null mutant is sensitive to calcofluor white, leads to zinc accumulation in cytosol; ortholog of the mouse KE4 and member of the ZIP (ZRT, IRT-like Protein) family"	1	0	0	0.75	0.904761905	0.857142857	0.85	0.125
2200_OG5_129141_4 - EUKARYOTES_YFR027W	YFR027W	ECO1 - Acetyltransferase required for establishment of sister chromatid cohesion; modifies Smc3p at replication forks and Mcd1p in response to ds DNA breaks; has a C2H2-type zinc finger; mutations in human homolog ESCO2 cause Roberts syndrome	1	0	0	0.75	0.80952381	1	0.8	0.125
2201_OG5_130056_4 - EUKARYOTES_YHL030W	YHL030W	ECM29 - Scaffold protein that assists in association of the proteasome core particle with the regulatory particle; degraded by the mature proteasome after assembly; contains HEAT-like repeats	1	0	0	0.75	0.80952381	1	0.8	0.125
2202_OG5_128821_4 - EUKARYOTES_YBR103W	YBR103W	"SIF2 - WD40 repeat-containing subunit of the Set3C histone deacetylase complex, which represses early/middle sporulation genes; antagonizes telomeric silencing; binds specifically to the Sir4p N-terminus"	1	0	0	1	0.80952381	1	0.55	0.5
2203_OG5_127390_4 - EUKARYOTES_YAL003W	YAL003W	"EFB1 - Translation elongation factor 1 beta; stimulates nucleotide exchange to regenerate EF-1 alpha-GTP for the next elongation cycle; part of the EF-1 complex, which facilitates binding of aminoacyl-tRNA to the ribosomal A site"	1	0	0	0.5	0.857142857	1	1	0.875
2204_OG5_127392_4 - EUKARYOTES_YDR373W	YDR373W	FRQ1 - N-myristoylated calcium-binding protein that may have a role in intracellular signaling through its regulation of the phosphatidylinositol 4-kinase Pik1p; member of the recoverin/frequenin branch of the EF-hand superfamily	1	0	0	0.5	0.857142857	1	1	0.3125
2205_OG5_127617_4 - EUKARYOTES_YKL056C	YKL056C	TMA19 - Protein that associates with ribosomes; homolog of translationally controlled tumor protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and relocates to the mitochondrial outer surface upon oxidative stress	1	0	0	0.5	0.857142857	1	1	0.875
2206_OG5_128391_4 - EUKARYOTES_YDL135C	YDL135C	RDI1 - Rho GDP dissociation inhibitor involved in the localization and regulation of Cdc42p and Rho1p	1	0	0	0.5	0.857142857	1	1	0.25
2207_OG5_128861_4 - EUKARYOTES_YKL025C	YKL025C	"PAN3 - Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes"	1	0	0	0.5	0.857142857	1	1	0.25
2208_OG5_128870_4 - EUKARYOTES_YIL034C	YIL034C	CAP2 - Beta subunit of the capping protein (CP) heterodimer (Cap1p and Cap2p) which binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches	1	0	0	0.5	0.857142857	1	1	0.4375
2209_OG5_129037_4 - EUKARYOTES_YBR223C	YBR223C	"TDP1 - Tyrosyl-DNA Phosphodiesterase I, hydrolyzes 3' and 5'-phosphotyrosyl bonds, involved in the repair of DNA lesions created by topoisomerase I and topoisomerase II; mutations in human homolog result in the neurodegenerative disease SCANI"	1	0	0	0.75	0.857142857	1	0.75	0.375
2210_OG5_129205_4 - EUKARYOTES_YMR092C	YMR092C	"AIP1 - Actin cortical patch component, interacts with the actin depolymerizing factor cofilin; required to restrict cofilin localization to cortical patches; contains WD repeats"	1	0	0	0.5	0.904761905	1	0.95	0.25
2211_OG5_129786_4 - EUKARYOTES_YGL155W	YGL155W	"CDC43 - Beta subunit of geranylgeranyltransferase type I, catalyzes geranylgeranylation to the cysteine residue in proteins containing a C-terminal CaaX sequence ending in Leu or Phe; has substrates important for morphogenesis"	1	0	0	0.5	0.904761905	1	0.95	0.1875
2212_OG5_129813_4 - EUKARYOTES_YKL110C	YKL110C	"KTI12 - Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p"	1	0	0	0.875	0.904761905	0.571428571	1	0.1875
2213_OG5_128087_4 - EUKARYOTES_YLR038C	YLR038C	"COX12 - Subunit VIb of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; required for assembly of cytochrome c oxidase but not required for activity after assembly; phosphorylated"	1	0	0	0.875	0.666666667	0.857142857	0.95	0.4375
2214_OG5_128414_4 - EUKARYOTES_YBR004C	YBR004C	"GPI18 - Functional ortholog of human PIG-V, which is a mannosyltransferase that transfers the second mannose in glycosylphosphatidylinositol biosynthesis; the authentic, non-tagged protein was localized to mitochondria"	1	0	0	0.875	0.714285714	0.857142857	0.9	0.6875
2215_OG5_129440_4 - EUKARYOTES_YGR098C	YGR098C	"ESP1 - Separase, a caspase-like cysteine protease that promotes sister chromatid separation by mediating dissociation of the cohesin Scc1p from chromatin; inhibits protein phosphatase 2A-Cdc55p to promote mitotic exit; inhibited by Pds1p"	1	0	0	0.75	0.666666667	0.928571429	1	0.25
2216_OG5_130113_4 - EUKARYOTES_YLR088W	YLR088W	"GAA1 - Subunit of the GPI (glycosylphosphatidylinositol):protein transamidase complex, removes the GPI-anchoring signal and attaches GPI to proteins in the ER"	1	0	0	0.75	0.666666667	0.928571429	1	0.125
2217_OG5_130003_4 - EUKARYOTES_YML098W	YML098W	"TAF13 - TFIID subunit (19 kDa), involved in RNA polymerase II transcription initiation, similar to histone H4 with atypical histone fold motif of Spt3-like transcription factors"	1	0	0	0.875	0.761904762	0.857142857	0.85	0.25
2218_OG5_128257_4 - EUKARYOTES_YIL148W	YIL148W	"RPL40A - Fusion protein, identical to Rpl40Bp, that is cleaved to yield ubiquitin and a ribosomal protein of the large (60S) ribosomal subunit with similarity to rat L40; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes"	1	0	0	0.875	0.80952381	0.857142857	0.8	0.6875
2219_OG5_128257_4 - EUKARYOTES_YKR094C	YKR094C	"RPL40B - Fusion protein, identical to Rpl40Ap, that is cleaved to yield ubiquitin and a ribosomal protein of the large (60S) ribosomal subunit with similarity to rat L40; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes"	1	0	0	0.875	0.80952381	0.857142857	0.8	0.6875
2220_OG5_130340_4 - EUKARYOTES_YCL016C	YCL016C	"DCC1 - Subunit of a complex with Ctf8p and Ctf18p that shares some components with Replication Factor C, required for sister chromatid cohesion and telomere length maintenance"	1	0	0	1	0.761904762	0.928571429	0.65	0.1875
2221_OG5_130098_4 - EUKARYOTES_YPR189W	YPR189W	"SKI3 - Ski complex component and TPR protein, mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay"	1	0.0625	0	0.625	0.714285714	1	1	0.0625
2222_OG5_128350_4 - EUKARYOTES_YDL045C	YDL045C	"FAD1 - Flavin adenine dinucleotide (FAD) synthetase, performs the second step in synthesis of FAD from riboflavin"	1	0	0	0.625	0.857142857	0.857142857	1	0.6875
2223_OG5_129893_4 - EUKARYOTES_YDR325W	YDR325W	"YCG1 - Subunit of the condensin complex; required for establishment and maintenance of chromosome condensation, chromosome segregation and chromatin binding of the condensin complex; required for clustering of tRNA genes at the nucleolus"	1	0	0	0.625	0.714285714	1	1	0.125
2224_OG5_130021_4 - EUKARYOTES_YOR075W	YOR075W	"UFE1 - t-SNARE required for retrograde vesicular traffic and homotypic ER membrane fusion; forms a complex with the SNAREs Sec22p, Sec20p and Use1p to mediate fusion of Golgi-derived vesicles at the ER"	1	0	0	0.625	0.714285714	1	1	0.125
2225_OG5_130120_4 - EUKARYOTES_YNL261W	YNL261W	"ORC5 - Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing"	1	0	0	0.625	0.714285714	1	1	0.125
2226_OG5_128864_4 - EUKARYOTES_YDL077C	YDL077C	VAM6 - Vacuolar protein that plays a critical role in the tethering steps of vacuolar membrane fusion by facilitating guanine nucleotide exchange on small guanosine triphosphatase Ypt7p	1	0	0	0.625	0.761904762	1	0.95	0.375
2227_OG5_129856_4 - EUKARYOTES_YOR154W	YOR154W	SLP1 - Integral membrane protein of unknown function; member of the SUN-like family of proteins; genetic interactions suggest a role in folding of ER membrane proteins	1	0	0	0.625	0.761904762	1	0.95	0.0625
2228_OG5_130006_4 - EUKARYOTES_YNL124W	YNL124W	"NAF1 - RNA-binding protein required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing, forms a complex with Shq1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; similar to Gar1p"	1	0	0	0.625	0.761904762	1	0.95	0.125
2229_OG5_129118_4 - EUKARYOTES_YNL265C	YNL265C	IST1 - Protein with a positive role in the multivesicular body sorting pathway; functions and forms a complex with Did2p; recruitment to endosomes is mediated by the Vps2p-Vps24p subcomplex of ESCRT-III; also interacts with Vps4p	1	0	0	0.625	0.80952381	1	0.9	0.3125
2230_OG5_129557_4 - EUKARYOTES_YER159C	YER159C	BUR6 - Subunit of a heterodimeric NC2 transcription regulator complex with Ncb2p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2alpha	1	0	0	1	0.619047619	0.714285714	1	0.1875
2231_OG5_129648_4 - EUKARYOTES_YDR142C	YDR142C	PEX7 - Peroxisomal signal receptor for the N-terminal nonapeptide signal (PTS2) of peroxisomal matrix proteins; WD repeat protein; defects in human homolog cause lethal rhizomelic chondrodysplasia punctata (RCDP)	1	0	0	1	0.476190476	0.857142857	1	0.3125
2232_OG5_128020_4 - EUKARYOTES_YHR113W	YHR113W	APE4 - Cytoplasmic aspartyl aminopeptidase that may also function in the vacuole; CVT pathway cargo protein; cleaves unblocked N-terminal acidic amino acids from peptide substrates; forms a 12-subunit homo-oligomer; M18 metalloprotease family	1	0	0.111111111	1	0.523809524	0.857142857	0.95	0.75
2233_OG5_129984_4 - EUKARYOTES_YFR038W	YFR038W	IRC5 - Putative ATPase containing the DEAD/H helicase-related sequence motif; null mutant displays increased levels of spontaneous Rad52p foci	1	0	0	1	0.380952381	1	0.95	0.0625
2234_OG5_129834_4 - EUKARYOTES_YPL236C	YPL236C	YPL236C - 0	1	0	0	0.875	0.571428571	0.928571429	0.95	0.125
2235_OG5_129091_4 - EUKARYOTES_YPL263C	YPL263C	KEL3 - Cytoplasmic protein of unknown function	1	0	0	1	0.523809524	1	0.8	0.625
2236_OG5_130190_4 - EUKARYOTES_YMR149W	YMR149W	"SWP1 - Delta subunit of the oligosaccharyl transferase glycoprotein complex, which is required for N-linked glycosylation of proteins in the endoplasmic reticulum"	1	0	0	0.75	0.714285714	0.857142857	1	0.125
2237_OG5_128851_4 - EUKARYOTES_YFL034W	YFL034W	"YFL034W - Putative integral membrane protein that interacts with Rpp0p, which is a component of the ribosomal stalk"	1	0	0.027777778	0.75	0.619047619	1	0.95	0.4375
2238_OG5_129536_4 - EUKARYOTES_YJR102C	YJR102C	"VPS25 - Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome"	1	0	0	0.75	0.904761905	0.714285714	0.95	0.25
2239_OG5_128954_4 - EUKARYOTES_YPL110C	YPL110C	"GDE1 - Glycerophosphocholine (GroPCho) phosphodiesterase; hydrolyzes GroPCho to choline and glycerolphosphate, for use as a phosphate source and as a precursor for phosphocholine synthesis; may interact with ribosomes"	1	0	0	0.875	0.714285714	0.928571429	0.8	0.3125
2240_OG5_128568_4 - EUKARYOTES_YGL033W	YGL033W	"HOP2 - Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair"	1	0	0	0.875	0.761904762	0.928571429	0.75	0.8125
2241_OG5_130087_4 - EUKARYOTES_YIL150C	YIL150C	MCM10 - Essential chromatin-associated protein involved in the initiation of DNA replication; required for the association of the MCM2-7 complex with replication origins	1	0	0	0.75	0.761904762	1	0.8	0.125
2242_OG5_128421_4 - EUKARYOTES_YNL169C	YNL169C	"PSD1 - Phosphatidylserine decarboxylase of the mitochondrial inner membrane, converts phosphatidylserine to phosphatidylethanolamine"	1	0	0.083333333	0.5	0.80952381	1	1	0.625
2243_OG5_127581_4 - EUKARYOTES_YAL039C	YAL039C	"CYC3 - Cytochrome c heme lyase (holocytochrome c synthase), attaches heme to apo-cytochrome c (Cyc1p or Cyc7p) in the mitochondrial intermembrane space; human ortholog may have a role in microphthalmia with linear skin defects (MLS)"	1	0	0	0.5	0.80952381	1	1	0.5
2244_OG5_127581_4 - EUKARYOTES_YKL087C	YKL087C	"CYT2 - Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1"	1	0	0	0.5	0.80952381	1	1	0.5
2245_OG5_128763_4 - EUKARYOTES_YJL041W	YJL041W	"NSP1 - Essential component of the nuclear pore complex, which mediates nuclear import and export, found in both the Nup82 and Nic96 complexes"	1	0	0	0.5	0.80952381	1	1	0.75
2246_OG5_129203_4 - EUKARYOTES_YGL073W	YGL073W	"HSF1 - Trimeric heat shock transcription factor, activates multiple genes in response to stresses that include hyperthermia; recognizes variable heat shock elements (HSEs) consisting of inverted NGAAN repeats; posttranslationally regulated"	1	0.0625	0	0.5	0.857142857	1	0.95	0.125
2247_OG5_127614_4 - EUKARYOTES_YDR129C	YDR129C	"SAC6 - Fimbrin, actin-bundling protein; cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton"	1	0	0	0.5	0.857142857	1	0.95	0.1875
2248_OG5_128472_4 - EUKARYOTES_YPL191C	YPL191C	YPL191C - Putative protein of unknown function; diploid deletion strain exhibits high budding index; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	1	0	0	1	0.476190476	0.928571429	0.9	0.625
2249_OG5_128472_4 - EUKARYOTES_YGL082W	YGL082W	YGL082W - Putative protein of unknown function; predicted prenylation/proteolysis target of Afc1p and Rce1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YGL082W is not an essential gene	1	0	0	1	0.476190476	0.928571429	0.9	0.625
2250_OG5_128897_4 - EUKARYOTES_YNL044W	YNL044W	"YIP3 - Protein localized to COPII vesicles, proposed to be involved in ER to Golgi transport; interacts with members of the Rab GTPase family and Yip1p; also interacts with Rtn1p"	1	0	0	1	0.619047619	0.785714286	0.9	0.25
2251_OG5_129364_4 - EUKARYOTES_YBR101C	YBR101C	"FES1 - Hsp70 (Ssa1p) nucleotide exchange factor, cytosolic homolog of Sil1p, which is the nucleotide exchange factor for BiP (Kar2p) in the endoplasmic reticulum"	1	0	0	0.875	0.571428571	0.857142857	1	0.1875
2252_OG5_129364_4 - EUKARYOTES_YOL031C	YOL031C	"SIL1 - Nucleotide exchange factor for the endoplasmic reticulum (ER) lumenal Hsp70 chaperone Kar2p, required for protein translocation into the ER; homolog of Yarrowia lipolytica SLS1; GrpE-like protein"	1	0	0	0.875	0.571428571	0.857142857	1	0.1875
2253_OG5_129343_4 - EUKARYOTES_YOR258W	YOR258W	"HNT3 - DNA 5' AMP hydrolase involved in DNA repair; member of the histidine triad (HIT) superfamily of nucleotide-binding proteins; homolog of Aprataxin, a Hint related protein that is mutated in individuals with ataxia with oculomotor apraxia"	1	0	0	0.875	0.476190476	1	0.95	0.125
2254_OG5_128284_4 - EUKARYOTES_YNL320W	YNL320W	"YNL320W - Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"	1	0	0.138888889	0.75	0.761904762	0.785714286	1	0.625
2255_OG5_128529_4 - EUKARYOTES_YGR158C	YGR158C	MTR3 - Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hMtr3p (EXOSC6)	1	0	0	0.75	0.761904762	0.785714286	1	0.8125
2256_OG5_129236_4 - EUKARYOTES_YOL022C	YOL022C	TSR4 - Cytoplasmic protein required for correct processing of the 20S pre-rRNA at site D to generate mature 18S rRNA; essential gene in S288C background but not in CEN.PK2	1	0	0	0.75	0.619047619	0.928571429	1	0.5
2257_OG5_130038_4 - EUKARYOTES_YKL165C	YKL165C	MCD4 - Protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; multimembrane-spanning protein that localizes to the endoplasmic reticulum; highly conserved among eukaryotes	1	0	0	0.75	0.714285714	0.928571429	0.9	0.125
2258_OG5_130183_4 - EUKARYOTES_YMR211W	YMR211W	"DML1 - Essential protein involved in mtDNA inheritance, may also function in the partitioning of the mitochondrial organelle or in the segregation of chromosomes, exhibits regions similar to members of a GTPase family"	1	0	0	0.75	0.714285714	0.928571429	0.9	0.0625
2259_OG5_128478_4 - EUKARYOTES_YBR086C	YBR086C	"IST2 - Plasma membrane protein that may be involved in osmotolerance, localizes to the mother cell in small-budded cells and to the bud in medium- and large-budded cells; mRNA is transported to the bud tip by an actomyosin-driven process"	1	0	0	0.625	0.666666667	1	1	0.1875
2260_OG5_130239_4 - EUKARYOTES_YMR048W	YMR048W	"CSM3 - Replication fork associated factor, required for stable replication fork pausing; component of the DNA replication checkpoint pathway; required for accurate chromosome segregation during meiosis"	1	0	0	0.75	0.761904762	0.928571429	0.85	0
2261_OG5_128552_4 - EUKARYOTES_YPL123C	YPL123C	"RNY1 - Vacuolar RNase of the T(2) family, relocalizes to the cytosol where it cleaves tRNAs upon oxidative or stationary phase stress; promotes apoptosis under stress conditions and this function is independent of its catalytic activity"	1	0	0.027777778	0.75	0.80952381	0.928571429	0.8	0.125
2262_OG5_128679_4 - EUKARYOTES_YPR107C	YPR107C	"YTH1 - Essential RNA-binding component of cleavage and polyadenylation factor, contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylation"	1	0	0	0.5	0.857142857	0.928571429	1	0.5625
2263_OG5_129083_4 - EUKARYOTES_YGL097W	YGL097W	"SRM1 - Nucleotide exchange factor for Gsp1p, localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; suppressor of the pheromone response pathway; potentially phosphorylated by Cdc28p"	1	0	0	0.5	0.857142857	0.928571429	1	0.625
2264_OG5_128416_4 - EUKARYOTES_YLR362W	YLR362W	"STE11 - Signal transducing MEK kinase involved in pheromone response and pseudohyphal/invasive growth pathways where it phosphorylates Ste7p, and the high osmolarity response pathway, via phosphorylation of Pbs2p; regulated by Ste20p and Ste50p"	1	0	0	1	0.333333333	1	0.95	0.125
2265_OG5_129679_4 - EUKARYOTES_YGL246C	YGL246C	RAI1 - Nuclear protein with decapping endonuclease activity targeted toward mRNAs with unmethylated 7-methylguanosine cap structures; binds to and stabilizes the exoribonuclease Rat1p; required for pre-rRNA processing; homologous to human DOM3Z	1	0	0	1	0.476190476	0.857142857	0.95	0.0625
2266_OG5_130077_4 - EUKARYOTES_YFL003C	YFL003C	"MSH4 - Protein involved in meiotic recombination, required for normal levels of crossing over, colocalizes with Zip2p to discrete foci on meiotic chromosomes, has homology to bacterial MutS protein"	1	0	0	0.75	0.904761905	0.928571429	0.7	0.125
2267_OG5_128655_4 - EUKARYOTES_YKR023W	YKR023W	"YKR023W - Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"	1	0.0625	0	0.625	0.857142857	1	0.8	0.75
2268_OG5_129886_4 - EUKARYOTES_YCR087C-A	YCR087C-A	YCR087C-A - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; YCR087C-A is not an essential gene	1	0	0	0.875	0.857142857	1	0.55	0.1875
2269_OG5_127827_4 - EUKARYOTES_YFR028C	YFR028C	"CDC14 - Protein phosphatase required for mitotic exit; located in the nucleolus until liberated by the FEAR and Mitotic Exit Network in anaphase, enabling it to act on key substrates to effect a decrease in CDK/B-cyclin activity and mitotic exit; required for meiosis I spindle disassembly; released from nucleolus upon entry into anaphase I of meiosis, resequestered in metaphase II, then released again upon entry into anaphase II; maintained in nucleolus by Cdc55p in early meiosis"	1	0	0	0.375	0.904761905	1	1	0.625
2270_OG5_129185_4 - EUKARYOTES_YEL020W-A	YEL020W-A	"TIM9 - Essential protein of the mitochondrial intermembrane space, forms a complex with Tim10p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner membrane"	1	0	0	0.875	0.714285714	0.785714286	0.9	0.4375
2271_OG5_129925_4 - EUKARYOTES_YDR182W	YDR182W	CDC1 - Putative lipid phosphatase of the endoplasmic reticulum; shows Mn2+ dependence and may affect Ca2+ signaling; mutants display actin and general growth defects and pleiotropic defects in cell cycle progression and organelle distribution	1	0	0	0.75	0.571428571	1	0.95	0.125
2272_OG5_129288_4 - EUKARYOTES_YHR007C	YHR007C	"ERG11 - Lanosterol 14-alpha-demethylase, catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family"	1	0	0.027777778	1	0.333333333	0.928571429	1	0.1875
2273_OG5_128351_4 - EUKARYOTES_YGR202C	YGR202C	"PCT1 - Cholinephosphate cytidylyltransferase, also known as CTP:phosphocholine cytidylyltransferase, rate-determining enzyme of the CDP-choline pathway for phosphatidylcholine synthesis, inhibited by Sec14p, activated upon lipid-binding"	1	0	0	0.5	0.761904762	1	1	0.625
2274_OG5_128708_4 - EUKARYOTES_YLR168C	YLR168C	"UPS2 - Mitochondrial intermembrane space protein involved in regulation of mitochondrial cardiolipin and phosphatidylethanolamine levels; null has defects in mitochondrial morphology; similar to Ups1p, Ups3p and to human PRELI"	1	0	0	0.5	0.761904762	1	1	0.4375
2275_OG5_128708_4 - EUKARYOTES_YDR185C	YDR185C	UPS3 - Mitochondrial protein of unknown function; similar to Ups1p and Ups2p which are involved in regulation of mitochondrial cardiolipin and phosphatidylethanolamine levels; null is viable but interacts synthetically with ups1 and ups2 mutations	1	0	0	0.5	0.761904762	1	1	0.4375
2276_OG5_129189_4 - EUKARYOTES_YDL017W	YDL017W	CDC7 - DDK (Dbf4-dependent kinase) catalytic subunit required for firing origins and replication fork progression in S phase through phosphorylation of Mcm2-7p complexes and Cdc45p; kinase activity correlates with cyclical DBF4 expression	1	0	0	0.5	0.761904762	1	1	0.3125
2277_OG5_129735_4 - EUKARYOTES_YPR055W	YPR055W	"SEC8 - Essential 121kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosis"	1	0	0	0.5	0.761904762	1	1	0.125
2278_OG5_129818_4 - EUKARYOTES_YGR194C	YGR194C	"XKS1 - Xylulokinase, converts D-xylulose and ATP to xylulose 5-phosphate and ADP; rate limiting step in fermentation of xylulose; required for xylose fermentation by recombinant S. cerevisiae strains"	1	0	0	0.5	0.761904762	1	1	0.0625
2279_OG5_128707_4 - EUKARYOTES_YKL007W	YKL007W	CAP1 - Alpha subunit of the capping protein (CP) heterodimer (Cap1p and Cap2p) which binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches	1	0	0	0.5	0.80952381	1	0.95	0.25
2280_OG5_129603_4 - EUKARYOTES_YER048W-A	YER048W-A	ISD11 - Protein required for mitochondrial iron-sulfur cluster biosynthesis	1	0	0	1	0.666666667	0.642857143	0.95	0.4375
2281_OG5_130308_4 - EUKARYOTES_YMR035W	YMR035W	"IMP2 - Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p"	1	0	0	0.75	0.619047619	0.928571429	0.95	0.0625
2282_OG5_128431_4 - EUKARYOTES_YDR018C	YDR018C	"YDR018C - Probable membrane protein with three predicted transmembrane domains; homologous to Ybr042cp, similar to C. elegans F55A11.5 and maize 1-acyl-glycerol-3-phosphate acyltransferase"	1	0	0	0.625	0.619047619	1	1	0.4375
2283_OG5_128431_4 - EUKARYOTES_YBR042C	YBR042C	CST26 - Protein required for incorporation of stearic acid into phosphatidylinositol; affects chromosome stability when overexpressed	1	0	0	0.625	0.619047619	1	1	0.4375
2284_OG5_129972_4 - EUKARYOTES_YPR168W	YPR168W	NUT2 - Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for transcriptional activation and has a role in basal transcription	1	0	0	0.875	0.761904762	0.857142857	0.75	0.1875
2285_OG5_130433_4 - EUKARYOTES_YJR134C	YJR134C	"SGM1 - Protein of unknown function, required for wild-type growth rate on galactose and mannose; localizes to COPI coated vesicles and the Golgi apparatus"	1	0	0	0.875	0.619047619	1	0.75	0.125
2286_OG5_128879_4 - EUKARYOTES_YIL004C	YIL004C	BET1 - Type II membrane protein required for vesicular transport between the endoplasmic reticulum and Golgi complex; v-SNARE with similarity to synaptobrevins	1	0	0	0.625	0.80952381	0.857142857	0.95	0.625
2287_OG5_130257_4 - EUKARYOTES_YGR227W	YGR227W	"DIE2 - Dolichyl-phosphoglucose-dependent alpha-1,2 glucosyltransferase of the ER, functions in the pathway that synthesizes the dolichol-linked oligosaccharide precursor for N-linked protein glycosylation, has a role in regulation of ITR1 and INO1"	1	0	0	0.625	0.714285714	1	0.9	0.0625
2288_OG5_129379_4 - EUKARYOTES_YDL154W	YDL154W	"MSH5 - Protein of the MutS family, forms a dimer with Msh4p that facilitates crossovers between homologs during meiosis; msh5-Y823H mutation confers tolerance to DNA alkylating agents; homologs present in C. elegans and humans"	1	0	0	0.875	0.714285714	1	0.65	0.25
2289_OG5_128153_4 - EUKARYOTES_YJL208C	YJL208C	"NUC1 - Major mitochondrial nuclease, has RNAse and DNA endo- and exonucleolytic activities; has roles in mitochondrial recombination, apoptosis and maintenance of polyploidy"	1	0	0.111111111	0.5	0.80952381	0.928571429	1	0.5
2290_OG5_128665_4 - EUKARYOTES_YOR126C	YOR126C	"IAH1 - Isoamyl acetate-hydrolyzing esterase, required in balance with alcohol acetyltransferase to maintain optimal amounts of isoamyl acetate, which is particularly important in sake brewing"	1	0	0.055555556	1	0.238095238	1	1	0.25
2291_OG5_129751_4 - EUKARYOTES_YDR329C	YDR329C	PEX3 - Peroxisomal membrane protein (PMP) required for proper localization and stability of PMPs; anchors peroxisome retention factor Inp1p at the peroxisomal membrane; interacts with Pex19p	1	0	0	0.5	0.80952381	0.928571429	1	0.0625
2292_OG5_129060_4 - EUKARYOTES_YJR116W	YJR116W	TDA4 - Putative protein of unknown function; null mutant is sensitive to expression of the top1-T722A allele	1	0	0	1	0.333333333	1	0.9	0.0625
2293_OG5_126802_4 - EUKARYOTES_YER020W	YER020W	"GPA2 - Nucleotide binding alpha subunit of the heterotrimeric G protein that interacts with the receptor Gpr1p, has signaling role in response to nutrients; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery"	1	0	0	0.375	0.857142857	1	1	0.1875
2294_OG5_126802_4 - EUKARYOTES_YHR005C	YHR005C	GPA1 - GTP-binding alpha subunit of the heterotrimeric G protein that couples to pheromone receptors; negatively regulates the mating pathway by sequestering G(beta)gamma and by triggering an adaptive response; activates Vps34p at the endosome	1	0	0	0.375	0.857142857	1	1	0.1875
2295_OG5_126859_4 - EUKARYOTES_YOR327C	YOR327C	SNC2 - Vesicle membrane receptor protein (v-SNARE) involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins	1	0	0	0.375	0.857142857	1	1	0.6875
2296_OG5_126859_4 - EUKARYOTES_YAL030W	YAL030W	SNC1 - Vesicle membrane receptor protein (v-SNARE) involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; proposed to be involved in endocytosis; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins	1	0	0	0.375	0.857142857	1	1	0.6875
2297_OG5_127431_4 - EUKARYOTES_YDR069C	YDR069C	"DOA4 - Ubiquitin isopeptidase, required for recycling ubiquitin from proteasome-bound ubiquitinated intermediates, acts at the late endosome/prevacuolar compartment to recover ubiquitin from ubiquitinated membrane proteins en route to the vacuole"	1	0	0	0.375	0.857142857	1	1	0.5
2298_OG5_127431_4 - EUKARYOTES_YER144C	YER144C	"UBP5 - Putative ubiquitin-specific protease, closest paralog of Doa4p but has no functional overlap; concentrates at the bud neck"	1	0	0	0.375	0.857142857	1	1	0.5
2299_OG5_129180_4 - EUKARYOTES_YJR097W	YJR097W	"JJJ3 - Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein"	1	0	0	1	0.523809524	0.857142857	0.85	0.4375
2300_OG5_129113_4 - EUKARYOTES_YGR060W	YGR060W	"ERG25 - C-4 methyl sterol oxidase, catalyzes the first of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants accumulate the sterol intermediate 4,4-dimethylzymosterol"	1	0	0.027777778	0.75	0.476190476	1	1	0.0625
2301_OG5_128420_4 - EUKARYOTES_YLR350W	YLR350W	"ORM2 - Evolutionarily conserved protein, similar to Orm1p, required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control"	1	0	0	0.75	0.476190476	1	1	0.1875
2302_OG5_128420_4 - EUKARYOTES_YGR038W	YGR038W	"ORM1 - Evolutionarily conserved protein, similar to Orm2p, required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control"	1	0	0	0.75	0.476190476	1	1	0.1875
2303_OG5_130168_4 - EUKARYOTES_YGL241W	YGL241W	"KAP114 - Karyopherin, responsible for nuclear import of Spt15p, Sua7p, histones H2A and H2B, and Nap1p; amino terminus shows similarity to those of other importins, particularly Cse1p; localization is primarily nuclear"	1	0	0	0.75	0.476190476	1	1	0.125
2304_OG5_128756_4 - EUKARYOTES_YJR044C	YJR044C	VPS55 - Late endosomal protein involved in late endosome to vacuole trafficking; functional homolog of human obesity receptor gene-related protein (OB-RGRP)	1	0	0	0.625	0.666666667	0.928571429	1	0.125
2305_OG5_129620_4 - EUKARYOTES_YGL027C	YGL027C	"CWH41 - Processing alpha glucosidase I, ER type II integral membrane N-glycoprotein involved in assembly of cell wall beta 1,6 glucan and asparagine-linked protein glycosylation; also involved in ER protein quality control and sensing of ER stress"	1	0	0	0.75	0.761904762	0.857142857	0.85	0.25
2306_OG5_127835_4 - EUKARYOTES_YLR133W	YLR133W	"CKI1 - Choline kinase, catalyzing the first step in phosphatidylcholine synthesis via the CDP-choline (Kennedy pathway); exhibits some ethanolamine kinase activity contributing to phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway"	1	0	0	0.5	0.714285714	1	1	0.5625
2307_OG5_127835_4 - EUKARYOTES_YDR147W	YDR147W	"EKI1 - Ethanolamine kinase, primarily responsible for phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; exhibits some choline kinase activity, thus contributing to phosphatidylcholine synthesis via the CDP-choline pathway"	1	0	0	0.5	0.714285714	1	1	0.5625
2308_OG5_128363_4 - EUKARYOTES_YKR031C	YKR031C	"SPO14 - Phospholipase D, catalyzes the hydrolysis of phosphatidylcholine, producing choline and phosphatidic acid; involved in Sec14p-independent secretion; required for meiosis and spore formation; differently regulated in secretion and meiosis"	1	0	0	0.5	0.714285714	1	1	0.1875
2309_OG5_128867_4 - EUKARYOTES_YNL023C	YNL023C	"FAP1 - Protein that binds to Fpr1p, conferring rapamycin resistance by competing with rapamycin for Fpr1p binding; accumulates in the nucleus upon treatment of cells with rapamycin; has similarity to D. melanogaster shuttle craft and human NFX1"	1	0	0	0.5	0.857142857	0.857142857	1	0.25
2310_OG5_129741_4 - EUKARYOTES_YHR121W	YHR121W	LSM12 - Protein of unknown function that may function in RNA processing; interacts with Pbp1p and Pbp4p and associates with ribosomes; contains an RNA-binding LSM domain and an AD domain; GFP-fusion protein is induced by the DNA-damaging agent MMS	1	0	0	1	0.857142857	0.857142857	0.5	0.375
2311_OG5_126732_4 - EUKARYOTES_YCR034W	YCR034W	"FEN1 - Fatty acid elongase, involved in sphingolipid biosynthesis; acts on fatty acids of up to 24 carbons in length; mutations have regulatory effects on 1,3-beta-glucan synthase, vacuolar ATPase, and the secretory pathway"	1	0	0	0.5	0.80952381	1	0.9	0.5
2312_OG5_130123_4 - EUKARYOTES_YML068W	YML068W	"ITT1 - Protein that modulates the efficiency of translation termination, interacts with translation release factors eRF1 (Sup45p) and eRF3 (Sup35p) in vitro, contains a zinc finger domain characteristic of the TRIAD class of proteins"	1	0	0	0.875	0.428571429	1	0.9	0.0625
2313_OG5_129989_4 - EUKARYOTES_YKL205W	YKL205W	LOS1 - Nuclear pore protein involved in nuclear export of pre-tRNA and in re-export of mature tRNAs after their retrograde import from the cytoplasm	1	0	0	0.75	0.523809524	0.928571429	1	0.0625
2314_OG5_130158_4 - EUKARYOTES_YDR363W-A	YDR363W-A	SEM1 - Component of the lid subcomplex of the regulatory subunit of the 26S proteasome; involved in mRNA export mediated by the TREX-2 complex (Sac3p-Thp1p); ortholog of human DSS1	1	0	0	0.875	0.666666667	0.857142857	0.8	0.0625
2315_OG5_127260_4 - EUKARYOTES_YCR026C	YCR026C	NPP1 - Nucleotide pyrophosphatase/phosphodiesterase family member; mediates extracellular nucleotide phosphate hydrolysis along with Npp2p and Pho5p; activity and expression enhanced during conditions of phosphate starvation	1	0.0625	0.083333333	0.625	0.619047619	1	0.95	0.0625
2316_OG5_127260_4 - EUKARYOTES_YEL016C	YEL016C	NPP2 - Nucleotide pyrophosphatase/phosphodiesterase family member; mediates extracellular nucleotide phosphate hydrolysis along with Npp1p and Pho5p; activity and expression enhanced during conditions of phosphate starvation	1	0.0625	0.083333333	0.625	0.619047619	1	0.95	0.0625
2317_OG5_129504_4 - EUKARYOTES_YLR270W	YLR270W	"DCS1 - Non-essential hydrolase involved in mRNA decapping, may function in a feedback mechanism to regulate deadenylation, contains pyrophosphatase activity and a HIT (histidine triad) motif; interacts with neutral trehalase Nth1p"	1	0	0	0.5	0.761904762	0.928571429	1	0.25
2318_OG5_129504_4 - EUKARYOTES_YOR173W	YOR173W	"DCS2 - Non-essential, stress induced regulatory protein; modulates m7G-oligoribonucleotide metabolism; inhibits Dcs1p; regulated by Msn2p, Msn4p, and the Ras-cAMP-cAPK signaling pathway; mutant has increased aneuploidy tolerance"	1	0	0	0.5	0.761904762	0.928571429	1	0.25
2319_OG5_128835_4 - EUKARYOTES_YOR058C	YOR058C	ASE1 - Mitotic spindle midzone localized microtubule-associated protein (MAP) family member; required for spindle elongation and stabilization; undergoes cell cycle-regulated degradation by anaphase promoting complex; potential Cdc28p substrate	1	0	0	0.5	0.80952381	0.928571429	0.95	0.125
2320_OG5_128991_4 - EUKARYOTES_YOR181W	YOR181W	"LAS17 - Actin assembly factor, activates the Arp2/3 protein complex that nucleates branched actin filaments; localizes with the Arp2/3 complex to actin patches; homolog of the human Wiskott-Aldrich syndrome protein (WASP)"	1	0	0	0.375	0.80952381	1	1	0.125
2321_OG5_129107_4 - EUKARYOTES_YOR287C	YOR287C	RRP36 - Component of 90S preribosomes; involved in early cleavages of the 35S pre-rRNA and in production of the 40S ribosomal subunit	1	0	0	0.875	0.80952381	0.5	1	0.625
2322_OG5_130180_4 - EUKARYOTES_YOL069W	YOL069W	"NUF2 - Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering"	1	0	0	0.875	0.380952381	0.928571429	1	0.1875
2323_OG5_127048_4 - EUKARYOTES_YOR291W	YOR291W	"YPK9 - Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome"	1	0	0	0.375	0.857142857	1	0.95	0.625
2324_OG5_128815_4 - EUKARYOTES_YNL128W	YNL128W	TEP1 - Homolog of human tumor suppressor gene PTEN/MMAC1/TEP1 that has lipid phosphatase activity and is linked to the phosphatidylinositol signaling pathway; plays a role in normal sporulation	1	0	0	0.625	0.857142857	1	0.7	0.3125
2325_OG5_129128_4 - EUKARYOTES_YDR437W	YDR437W	"GPI19 - Subunit of GPI-GlcNAc transferase involved in synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), which is the first intermediate in glycosylphosphatidylinositol (GPI) anchor synthesis, shares similarity with mammalian PIG-P"	1	0	0	0.75	0.571428571	0.857142857	1	0.4375
2326_OG5_129929_4 - EUKARYOTES_YCR045C	YCR045C	RRT12 - Probable subtilisin-family protease with a role in formation of the dityrosine layer of spore walls; localizes to the spore wall and also the nuclear envelope and ER region in mature spores	1	0.0625	0.111111111	1	0.666666667	0.857142857	0.65	0.125
2327_OG5_128767_4 - EUKARYOTES_YDR482C	YDR482C	CWC21 - Protein involved in RNA splicing by the spliceosome; component of a complex containing Cef1p; interacts genetically with ISY1 and BUD13; may bind RNA; has similarity to S. pombe Cwf21p	1	0	0.027777778	0.625	0.761904762	0.785714286	1	0.625
2328_OG5_127966_4 - EUKARYOTES_YHR072W	YHR072W	"ERG7 - Lanosterol synthase, an essential enzyme that catalyzes the cyclization of squalene 2,3-epoxide, a step in ergosterol biosynthesis"	1	0	0.138888889	1	0.238095238	0.928571429	1	0.1875
2329_OG5_129355_4 - EUKARYOTES_YIL064W	YIL064W	SEE1 - Probable lysine methyltransferase involved in the dimethylation of eEF1A (Tef1p/Tef2p); sequence similarity to S-adenosylmethionine-dependent methyltransferases of the seven beta-strand family; role in vesicular transport	1	0	0.027777778	0.5	0.80952381	0.857142857	1	0.25
2330_OG5_128995_4 - EUKARYOTES_YBR186W	YBR186W	"PCH2 - Nucleolar component of the pachytene checkpoint, which prevents chromosome segregation when recombination and chromosome synapsis are defective; also represses meiotic interhomolog recombination in the rDNA"	1	0	0	0.875	0.761904762	0.928571429	0.6	0.6875
2331_OG5_129386_4 - EUKARYOTES_YGR216C	YGR216C	"GPI1 - Membrane protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; human and mouse GPI1p are functional homologs"	1	0	0	0.5	0.714285714	1	0.95	0.375
2332_OG5_130552_4 - EUKARYOTES_YPL164C	YPL164C	MLH3 - Protein involved in DNA mismatch repair and crossing-over during meiotic recombination; forms a complex with Mlh1p; mammalian homolog is implicated mammalian microsatellite instability	1	0	0	0.875	0.380952381	1	0.9	0.125
2333_OG5_130270_4 - EUKARYOTES_YDR079C-A	YDR079C-A	TFB5 - Component of the RNA polymerase II general transcription and DNA repair factor TFIIH; involved in transcription initiation and in nucleotide-excision repair; homolog of Chlamydomonas reinhardtii REX1-S protein involved in DNA repair	1	0	0	0.875	0.571428571	0.857142857	0.85	0.125
2334_OG5_130524_4 - EUKARYOTES_YDR434W	YDR434W	GPI17 - Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-Sp homolog	1	0	0	0.75	0.523809524	0.928571429	0.95	0.125
2335_OG5_129225_4 - EUKARYOTES_YGR159C	YGR159C	"NSR1 - Nucleolar protein that binds nuclear localization sequences, required for pre-rRNA processing and ribosome biogenesis"	1	0	0	0.625	0.523809524	1	1	0.5
2336_OG5_129941_4 - EUKARYOTES_YGR066C	YGR066C	YGR066C - Putative protein of unknown function	1	0	0	0.625	0.523809524	1	1	0.125
2337_OG5_129941_4 - EUKARYOTES_YBR105C	YBR105C	"VID24 - Peripheral membrane protein located at Vid (vacuole import and degradation) vesicles; regulates fructose-1,6-bisphosphatase (FBPase) targeting to the vacuole; promotes proteasome-dependent catabolite degradation of FBPase"	1	0	0	0.625	0.523809524	1	1	0.125
2338_OG5_128798_4 - EUKARYOTES_YIL062C	YIL062C	"ARC15 - Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches; has mRNA binding activity"	1	0	0	0.5	0.714285714	0.928571429	1	0.3125
2339_OG5_129744_4 - EUKARYOTES_YER127W	YER127W	LCP5 - Essential protein involved in maturation of 18S rRNA; depletion leads to inhibited pre-rRNA processing and reduced polysome levels; localizes primarily to the nucleolus	1	0	0	0.5	0.714285714	0.928571429	1	0.1875
2340_OG5_129470_4 - EUKARYOTES_YHR190W	YHR190W	"ERG9 - Farnesyl-diphosphate farnesyl transferase (squalene synthase), joins two farnesyl pyrophosphate moieties to form squalene in the sterol biosynthesis pathway"	1	0.125	0.055555556	1	0.285714286	0.857142857	1	0.1875
2341_OG5_129418_4 - EUKARYOTES_YLR316C	YLR316C	"TAD3 - Subunit of tRNA-specific adenosine-34 deaminase, forms a heterodimer with Tad2p that converts adenosine to inosine at the wobble position of several tRNAs"	1	0	0	0.875	0.857142857	0.857142857	0.55	0.5
2342_OG5_128151_4 - EUKARYOTES_YPR031W	YPR031W	NTO1 - Subunit of the NuA3 histone acetyltransferase complex that acetylates histone H3; contains PHD finger domain that interacts with methylated histone H3	1	0	0	0.375	0.761904762	1	1	0.25
2343_OG5_129961_4 - EUKARYOTES_YMR201C	YMR201C	RAD14 - Protein that recognizes and binds damaged DNA during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); contains zinc finger motif; homolog of human XPA protein	1	0	0	0.375	0.761904762	1	1	0.25
2344_OG5_130253_4 - EUKARYOTES_YER049W	YER049W	"TPA1 - Poly(rA)-binding protein involved in translation termination efficiency, mRNA poly(A) tail length and mRNA stability; interacts with Sup45p (eRF1), Sup35p (eRF3) and Pab1p; similar to prolyl 4-hydroxylases; binds Fe(III) and 2-oxoglutarate"	1	0	0	0.375	0.761904762	1	1	0.0625
2345_OG5_127826_4 - EUKARYOTES_YPL015C	YPL015C	HST2 - Cytoplasmic member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases; modulates nucleolar (rDNA) and telomeric silencing; possesses NAD(+)-dependent histone deacetylase activity in vitro	1	0.0625	0.055555556	0.375	0.80952381	1	0.95	0.375
2346_OG5_127917_4 - EUKARYOTES_YER169W	YER169W	RPH1 - JmjC domain-containing histone demethylase; specifically demethylates H3K36 tri- and dimethyl modification states; associates with actively transcribed (RNA polymerase II) regions in vivo and specifically targets H3K36 in its trimethylation state as its substrate; transcriptional repressor of PHR1; Rph1p phosphorylation during DNA damage is under control of the MEC1-RAD53 pathway	1	0	0	0.375	0.80952381	1	0.95	0.0625
2347_OG5_129439_4 - EUKARYOTES_YJR093C	YJR093C	"FIP1 - Subunit of cleavage polyadenylation factor (CPF), interacts directly with poly(A) polymerase (Pap1p) to regulate its activity; bridging factor that links Pap1p and the CPF complex via Yth1p"	1	0	0	0.375	0.80952381	1	0.95	0.25
2348_OG5_129026_4 - EUKARYOTES_YDL008W	YDL008W	"APC11 - Catalytic core subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; contains a RING-H2 domain that is required for activity"	1	0	0	1	0.761904762	0.571428571	0.8	0.75
2349_OG5_130528_4 - EUKARYOTES_YPL098C	YPL098C	MGR2 - Protein required for growth of cells lacking the mitochondrial genome	1	0	0	0.75	0.666666667	0.714285714	1	0.0625
2350_OG5_129931_4 - EUKARYOTES_YGL251C	YGL251C	HFM1 - Meiosis specific DNA helicase involved in the conversion of double-stranded breaks to later recombination intermediates and in crossover control; catalyzes the unwinding of Holliday junctions; has ssDNA and dsDNA stimulated ATPase activity	1	0	0	1	0.380952381	1	0.75	0.25
2351_OG5_129106_4 - EUKARYOTES_YDL085C-A	YDL085C-A	YDL085C-A - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus	1	0	0	0.875	0.666666667	0.785714286	0.8	0.4375
2352_OG5_128789_4 - EUKARYOTES_YNL016W	YNL016W	"PUB1 - Poly (A)+ RNA-binding protein, abundant mRNP-component protein that binds mRNA and is required for stability of many mRNAs; component of glucose deprivation induced stress granules, involved in P-body-dependent granule assembly"	1	0	0	0.5	0.666666667	1	0.95	0.125
2353_OG5_129231_4 - EUKARYOTES_YGL243W	YGL243W	"TAD1 - tRNA-specific adenosine deaminase, deaminates adenosine-37 to inosine in tRNA-Ala"	1	0	0	0.5	0.666666667	1	0.95	0.0625
2354_OG5_129584_4 - EUKARYOTES_YGR001C	YGR001C	YGR001C - Putative protein of unknown function with similarity to methyltransferase family members; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; required for replication of Brome mosaic virus in S. cerevisiae	1	0	0	0.875	0.761904762	0.928571429	0.55	0.25
2355_OG5_129631_4 - EUKARYOTES_YHR164C	YHR164C	"DNA2 - Tripartite DNA replication factor with single-stranded DNA-dependent ATPase, ATP-dependent nuclease, and helicase activities; required for Okazaki fragment processing; involved in DNA repair; cell-cycle dependent localization"	1	0.125	0.027777778	0.5	0.714285714	1	0.9	0.3125
2356_OG5_128476_4 - EUKARYOTES_YOR007C	YOR007C	SGT2 - Glutamine-rich cytoplasmic protein that serves as a scaffold for binding Get4/5p and other proteins required to mediate posttranslational insertion of tail-anchored proteins into the ER membrane; has similarity to human cochaperone SGT	1	0	0	0.5	0.714285714	1	0.9	0.5
2357_OG5_129358_4 - EUKARYOTES_YMR012W	YMR012W	"CLU1 - eIF3 component of unknown function; deletion causes defects in mitochondrial organization but not in growth or translation initiation, can rescue cytokinesis and mitochondrial organization defects of the Dictyostelium cluA- mutant"	1	0	0	0.5	0.714285714	1	0.9	0.3125
2358_OG5_130474_4 - EUKARYOTES_YJL011C	YJL011C	"RPC17 - RNA polymerase III subunit C17; physically interacts with C31, C11, and TFIIIB70; may be involved in the recruitment of pol III by the preinitiation complex"	1	0	0	0.75	0.714285714	1	0.65	0.125
2359_OG5_128461_4 - EUKARYOTES_YMR027W	YMR027W	YMR027W - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR027W is not an essential gene	1	0	0	0.375	0.80952381	0.928571429	1	0.5
2360_OG5_128608_4 - EUKARYOTES_YOR109W	YOR109W	"INP53 - Polyphosphatidylinositol phosphatase, dephosphorylates multiple phosphatidylinositols; involved in trans Golgi network-to-early endosome pathway; hyperosmotic stress causes translocation to actin patches; contains Sac1 and 5-ptase domains"	1	0	0	0.375	0.80952381	0.928571429	1	0.4375
2361_OG5_128608_4 - EUKARYOTES_YNL106C	YNL106C	"INP52 - Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain"	1	0	0	0.375	0.80952381	0.928571429	1	0.4375
2362_OG5_128454_4 - EUKARYOTES_YOL092W	YOL092W	YOL092W - Putative protein of unknown function; predicted to contain six transmembrane domains and is 58% similar to the uncharacterized ORF YBR147W	1	0	0	0.875	0.285714286	1	0.95	0.1875
2363_OG5_128454_4 - EUKARYOTES_YDR352W	YDR352W	YDR352W - Putative protein of unknown function	1	0	0	0.875	0.285714286	1	0.95	0.1875
2364_OG5_128454_4 - EUKARYOTES_YBR147W	YBR147W	RTC2 - Protein of unknown function; identified in a screen for mutants with decreased levels of rDNA transcription; detected in highly purified mitochondria; null mutant suppresses cdc13-1; similar to a G-protein coupled receptor from S. pombe	1	0	0	0.875	0.285714286	1	0.95	0.1875
2365_OG5_128885_4 - EUKARYOTES_YBL102W	YBL102W	"SFT2 - Non-essential tetra-spanning membrane protein found mostly in the late Golgi, can suppress some sed5 alleles; may be part of the transport machinery, but precise function is unknown; similar to mammalian syntaxin 5"	1	0	0	0.875	0.714285714	0.571428571	0.95	0.6875
2366_OG5_129745_4 - EUKARYOTES_YNL221C	YNL221C	"POP1 - Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P"	1	0	0	0.375	0.857142857	0.928571429	0.95	0.25
2367_OG5_127640_4 - EUKARYOTES_YJR036C	YJR036C	"HUL4 - Protein with similarity to hect domain E3 ubiquitin-protein ligases, not essential for viability"	1	0	0	0.5	0.80952381	1	0.8	0.5625
2368_OG5_130550_4 - EUKARYOTES_YML036W	YML036W	"CGI121 - Component of the EKC/KEOPS complex with Bud32p, Kae1p, Pcc1p, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription; Cgi121p is dispensable for tRNA modification"	1	0	0	0.875	0.476190476	0.857142857	0.9	0.25
2369_OG5_127696_4 - EUKARYOTES_YAR002C-A	YAR002C-A	"ERP1 - Protein that forms a heterotrimeric complex with Erp2p, Emp24p, and Erv25p; member, along with Emp24p and Erv25p, of the p24 family involved in ER to Golgi transport and localized to COPII-coated vesicles"	1	0	0	0.25	0.857142857	1	1	0.5
2370_OG5_127696_4 - EUKARYOTES_YHR110W	YHR110W	"ERP5 - Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport"	1	0	0	0.25	0.857142857	1	1	0.5
2371_OG5_127696_4 - EUKARYOTES_YGL002W	YGL002W	"ERP6 - Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"	1	0	0	0.25	0.857142857	1	1	0.5
2372_OG5_128866_4 - EUKARYOTES_YBL047C	YBL047C	"EDE1 - Key endocytic protein involved in a network of interactions with other endocytic proteins, binds membranes in a ubiquitin-dependent manner, may also bind ubiquitinated membrane-associated proteins"	1	0	0	0.25	0.857142857	1	1	0.3125
2373_OG5_129033_4 - EUKARYOTES_YLL018C-A	YLL018C-A	"COX19 - Protein required for cytochrome c oxidase assembly, located in the cytosol and mitochondrial intermembrane space; putative copper metallochaperone that delivers copper to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs"	1	0	0	0.875	0.523809524	0.857142857	0.85	0.625
2374_OG5_127522_4 - EUKARYOTES_YJL197W	YJL197W	"UBP12 - Ubiquitin carboxyl-terminal hydrolase, ubiquitin-specific protease present in the nucleus and cytoplasm that cleaves ubiquitin from ubiquitinated proteins"	1	0	0	0.625	0.476190476	1	1	0.4375
2375_OG5_130535_4 - EUKARYOTES_YNL248C	YNL248C	RPA49 - RNA polymerase I subunit A49	1	0	0	0.625	0.619047619	0.857142857	1	0.0625
2376_OG5_130733_4 - EUKARYOTES_YKL206C	YKL206C	ADD66 - Protein involved in 20S proteasome assembly; forms a heterodimer with Pba1p that binds to proteasome precursors; similar to human PAC2 constituent of the PAC1-PAC2 complex involved in proteasome assembly	1	0	0	1	0.619047619	0.928571429	0.55	0.1875
2377_OG5_130536_4 - EUKARYOTES_YOR141C	YOR141C	"ARP8 - Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes; has mRNA binding activity"	1	0	0	0.5	0.666666667	0.928571429	1	0.0625
2378_OG5_129865_4 - EUKARYOTES_YPL271W	YPL271W	"ATP15 - Epsilon subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated"	1	0	0	1	0.619047619	0.714285714	0.75	0.3125
2379_OG5_129413_4 - EUKARYOTES_YMR222C	YMR222C	FSH2 - Putative serine hydrolase that localizes to the cytoplasm; sequence is similar to S. cerevisiae Fsh1p and Fsh3p and the human candidate tumor suppressor OVCA2	1	0	0	0.75	0.666666667	0.714285714	0.95	0.375
2380_OG5_129413_4 - EUKARYOTES_YOR280C	YOR280C	FSH3 - Putative serine hydrolase; likely target of Cyc8p-Tup1p-Rfx1p transcriptional regulation; sequence is similar to S. cerevisiae Fsh1p and Fsh2p and the human candidate tumor suppressor OVCA2	1	0	0	0.75	0.666666667	0.714285714	0.95	0.375
2381_OG5_130431_4 - EUKARYOTES_YGR181W	YGR181W	"TIM13 - Mitochondrial intermembrane space protein, forms a complex with Tim8p that delivers a subset of hydrophobic proteins to the TIM22 complex for insertion into the inner membrane"	1	0	0	0.75	0.666666667	0.714285714	0.95	0.1875
2382_OG5_130537_4 - EUKARYOTES_YDR302W	YDR302W	GPI11 - ER membrane protein involved in a late step of glycosylphosphatidylinositol (GPI) anchor assembly; involved in the addition of phosphoethanolamine to the multiply mannosylated GPI intermediate; human PIG-Fp is a functional homolog	1	0	0	0.75	0.428571429	1	0.9	0.0625
2383_OG5_130700_4 - EUKARYOTES_YGR188C	YGR188C	"BUB1 - Protein kinase involved in the cell cycle checkpoint into anaphase; forms complex with Mad1p and Bub3p crucial to preventing cell cycle progression into anaphase in the presence of spindle damage; CDC28-mediated phosphorylation at Bub1p-T566 is important for its degradation in anaphase and adaptation of the checkpoint to prolonged mitotic arrest, but not to its kinase activity or chromosome segregation function; associates with centromere DNA via Skp1p"	1	0	0	0.625	0.523809524	0.928571429	1	0
2384_OG5_130563_4 - EUKARYOTES_YIL128W	YIL128W	"MET18 - DNA repair and TFIIH regulator, required for both nucleotide excision repair (NER) and RNA polymerase II (RNAP II) transcription; involved in telomere maintenance"	1	0	0	0.625	0.619047619	0.928571429	0.9	0.125
2385_OG5_128824_4 - EUKARYOTES_YJL134W	YJL134W	"LCB3 - Long-chain base-1-phosphate phosphatase with specificity for dihydrosphingosine-1-phosphate, regulates ceramide and long-chain base phosphates levels, involved in incorporation of exogenous long chain bases in sphingolipids"	1	0	0.055555556	0.5	0.619047619	1	0.95	0.0625
2386_OG5_128824_4 - EUKARYOTES_YKR053C	YKR053C	"YSR3 - Dihydrosphingosine 1-phosphate phosphatase, membrane protein involved in sphingolipid metabolism; has similarity to Lcb3p"	1	0	0.055555556	0.5	0.619047619	1	0.95	0.0625
2387_OG5_127576_4 - EUKARYOTES_YJL079C	YJL079C	PRY1 - Protein of unknown function	1	0	0	0.5	0.666666667	1	0.9	0.1875
2388_OG5_127576_4 - EUKARYOTES_YKR013W	YKR013W	PRY2 - Protein of unknown function	1	0	0	0.5	0.666666667	1	0.9	0.1875
2389_OG5_130132_4 - EUKARYOTES_YOR005C	YOR005C	"DNL4 - DNA ligase required for nonhomologous end-joining (NHEJ), forms stable heterodimer with required cofactor Lif1p, interacts with Nej1p; involved in meiosis, not essential for vegetative growth"	1	0	0	0.375	0.761904762	0.928571429	1	0.25
2390_OG5_130723_4 - EUKARYOTES_YOL073C	YOL073C	YOL073C - Putative protein of unknown function	1	0	0	0.875	0.380952381	0.857142857	0.95	0.125
2391_OG5_130048_4 - EUKARYOTES_YJL062W	YJL062W	LAS21 - Integral plasma membrane protein involved in the synthesis of the glycosylphosphatidylinositol (GPI) core structure; mutations affect cell wall integrity	1	0	0.027777778	0.5	0.761904762	1	0.8	0.125
2392_OG5_128919_4 - EUKARYOTES_YDR126W	YDR126W	"SWF1 - Palmitoyltransferase that acts on transmembrane proteins, including the SNAREs Snc1p, Syn8p, Tlg1p and likely all SNAREs; contains an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; may have a role in vacuole fusion"	1	0	0	1	0.333333333	0.928571429	0.8	0.625
2393_OG5_128245_4 - EUKARYOTES_YPL111W	YPL111W	"CAR1 - Arginase, responsible for arginine degradation, expression responds to both induction by arginine and nitrogen catabolite repression; disruption enhances freeze tolerance"	1	0	0.166666667	0.25	0.80952381	1	1	0.3125
2394_OG5_127845_4 - EUKARYOTES_YMR036C	YMR036C	MIH1 - Protein tyrosine phosphatase involved in cell cycle control; regulates the phosphorylation state of Cdc28p; homolog of S. pombe cdc25	1	0	0	0.25	0.80952381	1	1	0.1875
2395_OG5_127847_4 - EUKARYOTES_YKR070W	YKR070W	"YKR070W - Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"	1	0	0	0.75	0.380952381	0.928571429	1	0.375
2396_OG5_128695_4 - EUKARYOTES_YDL101C	YDL101C	"DUN1 - Cell-cycle checkpoint serine-threonine kinase required for DNA damage-induced transcription of certain target genes, phosphorylation of Rad55p and Sml1p, and transient G2/M arrest after DNA damage; also regulates postreplicative DNA repair"	1	0	0	0.25	0.80952381	1	1	0.0625
2397_OG5_128695_4 - EUKARYOTES_YPL153C	YPL153C	"RAD53 - Protein kinase, required for cell-cycle arrest in response to DNA damage; activated by trans autophosphorylation when interacting with hyperphosphorylated Rad9p; also interacts with ARS1 and plays a role in initiation of DNA replication"	1	0	0	0.25	0.80952381	1	1	0.0625
2398_OG5_130103_4 - EUKARYOTES_YPR098C	YPR098C	"YPR098C - Protein of unknown function, localized to the mitochondrial outer membrane"	1	0	0.027777778	0.75	0.476190476	0.928571429	0.9	0
2399_OG5_130691_4 - EUKARYOTES_YMR038C	YMR038C	"CCS1 - Copper chaperone for superoxide dismutase Sod1p, involved in oxidative stress protection; Met-X-Cys-X2-Cys motif within the N-terminal portion is involved in insertion of copper into Sod1p under conditions of copper deprivation"	1	0	0	0.75	0.476190476	0.928571429	0.9	0
2400_OG5_129613_4 - EUKARYOTES_YMR043W	YMR043W	MCM1 - Transcription factor involved in cell-type-specific transcription and pheromone response; plays a central role in the formation of both repressor and activator complexes	1	0	0	0.5	0.761904762	0.785714286	1	0.125
2401_OG5_130230_4 - EUKARYOTES_YEL044W	YEL044W	IES6 - Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions; human ortholog INO80C is a member of the human INO80 complex; implicated in DNA repair based on genetic interactions with RAD52 epistasis genes	1	0	0	0.5	0.619047619	0.928571429	1	0.1875
2402_OG5_127642_4 - EUKARYOTES_YLR179C	YLR179C	YLR179C - Protein of unknown function with similarity to Tfs1p; transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance; GFP-tagged protein localizes to the cytoplasm and nucleus	1	0	0	0.5	0.666666667	0.928571429	0.95	0.25
2403_OG5_127642_4 - EUKARYOTES_YLR178C	YLR178C	TFS1 - Protein that interacts with and inhibits carboxypeptidase Y and Ira2p; phosphatidylethanolamine-binding protein (PEBP) family member; targets to vacuolar membranes during stationary phase; acetylated by NatB N-terminal acetyltransferase	1	0	0	0.5	0.666666667	0.928571429	0.95	0.25
2404_OG5_129812_4 - EUKARYOTES_YBL098W	YBL098W	"BNA4 - Kynurenine 3-mono oxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p; putative therapeutic target for Huntington disease"	1	0	0	0.5	0.80952381	0.928571429	0.8	0
2405_OG5_130185_4 - EUKARYOTES_YBR217W	YBR217W	ATG12 - Conserved ubiquitin-like modifier involved in autophagy and the Cvt pathway; conjugated to Atg5p to form a complex involved in Atg8p lipidation; Atg12p-Atg5p also forms a complex with Atg16p that is required for autophagosome formation	1	0	0	0.75	0.666666667	0.714285714	0.9	0.3125
2406_OG5_130395_4 - EUKARYOTES_YDL119C	YDL119C	"YDL119C - Putative mitochondrial transport protein; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in purified mitochondria"	1	0	0	0.625	0.476190476	0.928571429	1	0.1875
2407_OG5_128609_4 - EUKARYOTES_YFR003C	YFR003C	"YPI1 - Inhibitor of the type I protein phosphatase Glc7p, which is involved in regulation of a variety of metabolic processes; overproduction causes decreased cellular content of glycogen"	1	0	0	0.75	0.571428571	0.857142857	0.85	0.5625
2408_OG5_129618_4 - EUKARYOTES_YGL192W	YGL192W	IME4 - Probable mRNA N6-adenosine methyltransferase required for entry into meiosis; transcribed in diploid cells; haploids repress IME4 transcription via production of antisense IME4 transcripts; antisense transcription is repressed in diploids	1	0.0625	0.027777778	1	0.571428571	0.857142857	0.6	0.375
2409_OG5_130401_4 - EUKARYOTES_YPL183C	YPL183C	RTT10 - Cytoplasmic protein with a role in regulation of Ty1 transposition	1	0	0	0.75	0.476190476	1	0.8	0.0625
2410_OG5_128574_4 - EUKARYOTES_YDR375C	YDR375C	BCS1 - Mitochondrial protein of the AAA ATPase family; has ATP-dependent chaperone activity; required for assembly of Rip1p and Qcr10p into cytochrome bc(1) complex; mutations in human homolog BCS1L are linked to neonatal mitochondrial diseases	1	0	0	0.5	0.714285714	0.857142857	0.95	0.4375
2411_OG5_128750_4 - EUKARYOTES_YCR032W	YCR032W	"BPH1 - PProtein homologous to human Chediak-Higashi syndrome and murine Beige proteins, which are implicated in disease syndromes due to defective lysosomal trafficking; mutant phenotype and genetic interactions suggest a role in protein sorting"	1	0	0	0.375	0.714285714	0.928571429	1	0.125
2412_OG5_128848_4 - EUKARYOTES_YOR090C	YOR090C	PTC5 - Mitochondrial type 2C protein phosphatase (PP2C) involved in regulation of pyruvate dehydrogenase activity by dephosphorylating the serine 133 of the Pda1p subunit; acts in concert with kinases Pkp1p and Pkp2p and phosphatase Ptc6p	1	0	0	0.375	0.714285714	0.928571429	1	0.125
2413_OG5_130025_4 - EUKARYOTES_YPR191W	YPR191W	"QCR2 - Subunit 2 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; phosphorylated; transcription is regulated by Hap1p, Hap2p/Hap3p, and heme"	1	0	0	0.375	0.714285714	0.928571429	1	0.0625
2414_OG5_129393_4 - EUKARYOTES_YJL207C	YJL207C	LAA1 - AP-1 accessory protein; colocalizes with clathrin to the late-Golgi apparatus; involved in TGN-endosome transport; physically interacts with AP-1; similar to the mammalian p200; may interact with ribosomes; YJL207C is a non-essential gene	1	0	0	0.375	0.761904762	0.928571429	0.95	0.125
2415_OG5_129323_4 - EUKARYOTES_YOR357C	YOR357C	SNX3 - Sorting nexin required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p	1	0	0	0.25	0.80952381	1	0.95	0.1875
2416_OG5_130787_4 - EUKARYOTES_YJR034W	YJR034W	PET191 - Protein required for assembly of cytochrome c oxidase; exists as an oligomer that is integral to the mitochondrial inner membrane and faces the intermembrane space; contains a twin Cx9C motif	1	0	0	0.75	0.571428571	0.785714286	0.9	0
2417_OG5_130872_4 - EUKARYOTES_YLR271W	YLR271W	YLR271W - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS	1	0	0	0.75	0.476190476	0.928571429	0.85	0.0625
2418_OG5_128865_4 - EUKARYOTES_YBL026W	YBL026W	"LSM2 - Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA"	1	0	0	0.625	0.714285714	0.714285714	0.95	0.75
2419_OG5_130892_4 - EUKARYOTES_YDR030C	YDR030C	"RAD28 - Protein involved in DNA repair, related to the human CSA protein that is involved in transcription-coupled repair nucleotide excision repair"	1	0	0	0.875	0.428571429	1	0.7	0.0625
2420_OG5_129659_4 - EUKARYOTES_YDR330W	YDR330W	UBX5 - UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p	1	0	0	0.75	0.523809524	0.928571429	0.8	0.375
2421_OG5_130579_4 - EUKARYOTES_YML030W	YML030W	AIM31 - Putative protein of unknown function; GFP-fusion protein localizes to mitochondria; may interact with respiratory chain complexes III or IV; null mutant is viable and displays reduced frequency of mitochondrial genome loss	1	0	0	0.5	0.571428571	0.928571429	1	0.0625
2422_OG5_130307_4 - EUKARYOTES_YBR111W-A	YBR111W-A	"SUS1 - Protein involved in mRNA export coupled transcription activation and elongation; component of both the SAGA histone acetylase complex and TREX-2, and interacts with RNAPII"	1	0	0	0.875	0.619047619	1	0.5	0.125
2423_OG5_130351_4 - EUKARYOTES_YCR092C	YCR092C	"MSH3 - Mismatch repair protein, forms dimers with Msh2p that mediate repair of insertion or deletion mutations and removal of nonhomologous DNA ends, contains a PCNA (Pol30p) binding motif required for genome stability"	1	0	0	0.875	0.238095238	0.928571429	0.95	0.1875
2424_OG5_128113_4 - EUKARYOTES_YNR074C	YNR074C	"AIF1 - Mitochondrial cell death effector that translocates to the nucleus in response to apoptotic stimuli, homolog of mammalian Apoptosis-Inducing Factor, putative reductase"	1	0.125	0.055555556	1	0.238095238	1	0.75	0.25
2425_OG5_130894_4 - EUKARYOTES_YDL156W	YDL156W	"YDL156W - Putative protein of unknown function; protein sequence contains three WD domains (WD-40 repeat); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; potential regulatory target of Mbp1p, which binds to the YDL156W promoter region"	1	0	0	0.75	0.285714286	1	0.95	0.0625
2426_OG5_128869_4 - EUKARYOTES_YKR092C	YKR092C	"SRP40 - Nucleolar, serine-rich protein with a role in preribosome assembly or transport; may function as a chaperone of small nucleolar ribonucleoprotein particles (snoRNPs); immunologically and structurally to rat Nopp140"	1	0	0.055555556	0.5	0.666666667	0.857142857	0.95	0.4375
2427_OG5_128036_4 - EUKARYOTES_YNR065C	YNR065C	YNR065C - Protein of unknown function; protein-protein interactions suggest a possible role in actin patch formation; YNR065C is not an essential gene	1	0	0	0.5	0.523809524	1	0.95	0.5
2428_OG5_128036_4 - EUKARYOTES_YBL017C	YBL017C	PEP1 - Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments	1	0	0	0.5	0.523809524	1	0.95	0.5
2429_OG5_128036_4 - EUKARYOTES_YIL173W	YIL173W	"VTH1 - Putative membrane glycoprotein with strong similarity to Vth2p and Pep1p/Vps10p, may be involved in vacuolar protein sorting"	1	0	0	0.5	0.523809524	1	0.95	0.5
2430_OG5_128036_4 - EUKARYOTES_YJL222W	YJL222W	"VTH2 - Putative membrane glycoprotein with strong similarity to Vth1p and Pep1p/Vps10p, may be involved in vacuolar protein sorting"	1	0	0	0.5	0.523809524	1	0.95	0.5
2431_OG5_130234_4 - EUKARYOTES_YNL059C	YNL059C	"ARP5 - Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes"	1	0	0	0.375	0.666666667	0.928571429	1	0.1875
2432_OG5_129532_4 - EUKARYOTES_YLR405W	YLR405W	"DUS4 - Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus3p"	1	0	0.194444444	0.625	0.761904762	0.928571429	0.65	0.25
2433_OG5_129508_4 - EUKARYOTES_YGR019W	YGR019W	UGA1 - Gamma-aminobutyrate (GABA) transaminase (4-aminobutyrate aminotransferase) involved in the 4-aminobutyrate and glutamate degradation pathways; required for normal oxidative stress tolerance and nitrogen utilization	1	0.0625	0.055555556	0.25	0.80952381	1	0.9	0.0625
2434_OG5_129500_4 - EUKARYOTES_YHR181W	YHR181W	"SVP26 - Integral membrane protein of the early Golgi apparatus and endoplasmic reticulum, involved in COP II vesicle transport; may also function to promote retention of proteins in the early Golgi compartment"	1	0	0	0.5	0.571428571	0.928571429	0.95	0.375
2435_OG5_129614_4 - EUKARYOTES_YMR118C	YMR118C	YMR118C - Protein of unknown function with similarity to succinate dehydrogenase cytochrome b subunit; YMR118C is not an essential gene	1	0	0.138888889	0.375	0.857142857	0.714285714	1	0.125
2436_OG5_129614_4 - EUKARYOTES_YKL141W	YKL141W	"SDH3 - Cytochrome b subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain"	1	0	0.138888889	0.375	0.857142857	0.714285714	1	0.125
2437_OG5_129749_4 - EUKARYOTES_YOL125W	YOL125W	TRM13 - 2'-O-methyltransferase responsible for modification of tRNA at position 4; C-terminal domain has similarity to Rossmann-fold (RFM) superfamily of RNA methyltransferases	1	0	0	0.875	0.761904762	0.857142857	0.45	0.3125
2438_OG5_130576_4 - EUKARYOTES_YNL259C	YNL259C	"ATX1 - Cytosolic copper metallochaperone that transports copper to the secretory vesicle copper transporter Ccc2p for eventual insertion into Fet3p, which is a multicopper oxidase required for high-affinity iron uptake"	1	0	0	0.875	0.523809524	0.642857143	0.9	0.125
2439_OG5_129485_4 - EUKARYOTES_YLR314C	YLR314C	"CDC3 - Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM"	1	0	0	0.25	0.761904762	0.928571429	1	0.1875
2440_OG5_129866_4 - EUKARYOTES_YBR289W	YBR289W	SNF5 - Subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf6p	1	0	0	0.375	0.714285714	1	0.85	0.1875
2441_OG5_129926_4 - EUKARYOTES_YCR075C	YCR075C	"ERS1 - Protein with similarity to human cystinosin, which is a H(+)-driven transporter involved in L-cystine export from lysosomes and implicated in the disease cystinosis; contains seven transmembrane domains"	1	0	0	0.5	0.80952381	0.928571429	0.7	0.1875
2442_OG5_129435_4 - EUKARYOTES_YMR013C	YMR013C	"SEC59 - Dolichol kinase, catalyzes the terminal step in dolichyl monophosphate (Dol-P) biosynthesis; required for viability and for normal rates of lipid intermediate synthesis and protein N-glycosylation"	1	0	0	0.75	0.952380952	0.785714286	0.45	0.5625
2443_OG5_129036_4 - EUKARYOTES_YNL246W	YNL246W	"VPS75 - NAP family histone chaperone; binds to histones and Rtt109p, stimulating histone acetyltransferase activity; possesses nucleosome assembly activity in vitro; proposed role in vacuolar protein sorting and in double-strand break repair"	1	0	0	0.75	0.619047619	1	0.55	0.5625
2444_OG5_127937_4 - EUKARYOTES_YBL032W	YBL032W	"HEK2 - RNA binding protein involved in the asymmetric localization of ASH1 mRNA; represses translation of ASH1 mRNA, an effect reversed by Yck1p-dependent phosphoryation; regulates telomere position effect and length; similarity to hnRNP-K"	1	0	0	0.25	0.666666667	1	1	0.125
2445_OG5_127937_4 - EUKARYOTES_YBR233W	YBR233W	"PBP2 - RNA binding protein with similarity to mammalian heterogeneous nuclear RNP K protein, involved in the regulation of telomere position effect and telomere length"	1	0	0	0.25	0.666666667	1	1	0.125
2446_OG5_129129_4 - EUKARYOTES_YFL009W	YFL009W	"CDC4 - F-box protein required for G1/S and G2/M transition, associates with Skp1p and Cdc53p to form a complex, SCFCdc4, which acts as ubiquitin-protein ligase directing ubiquitination of the phosphorylated CDK inhibitor Sic1p"	1	0	0	0.25	0.714285714	1	0.95	0.1875
2447_OG5_130597_4 - EUKARYOTES_YOR079C	YOR079C	"ATX2 - Golgi membrane protein involved in manganese homeostasis; overproduction suppresses the sod1 (copper, zinc superoxide dismutase) null mutation"	1	0	0	0.25	0.714285714	1	0.95	0.0625
2448_OG5_129861_4 - EUKARYOTES_YML086C	YML086C	"ALO1 - D-Arabinono-1,4-lactone oxidase, catalyzes the final step in biosynthesis of dehydro-D-arabinono-1,4-lactone, which is protective against oxidative stress"	1	0	0.083333333	1	0.333333333	0.571428571	1	0.25
2449_OG5_127769_4 - EUKARYOTES_YBR093C	YBR093C	PHO5 - Repressible acid phosphatase (1 of 3) that also mediates extracellular nucleotide-derived phosphate hydrolysis; secretory pathway derived cell surface glycoprotein; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2	1	0	0	0.5	0.571428571	0.928571429	0.9	0.125
2450_OG5_127769_4 - EUKARYOTES_YBR092C	YBR092C	"PHO3 - Constitutively expressed acid phosphatase similar to Pho5p; brought to the cell surface by transport vesicles; hydrolyzes thiamin phosphates in the periplasmic space, increasing cellular thiamin uptake; expression is repressed by thiamin"	1	0	0	0.5	0.571428571	0.928571429	0.9	0.125
2451_OG5_127769_4 - EUKARYOTES_YDL024C	YDL024C	"DIA3 - Protein of unknown function, involved in invasive and pseudohyphal growth"	1	0	0	0.5	0.571428571	0.928571429	0.9	0.125
2452_OG5_127769_4 - EUKARYOTES_YHR215W	YHR215W	"PHO12 - One of three repressible acid phosphatases, a glycoprotein that is transported to the cell surface by the secretory pathway; nearly identical to Pho11p; upregulated by phosphate starvation"	1	0	0	0.5	0.571428571	0.928571429	0.9	0.125
2453_OG5_127769_4 - EUKARYOTES_YAR071W	YAR071W	"PHO11 - One of three repressible acid phosphatases, a glycoprotein that is transported to the cell surface by the secretory pathway; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2"	1	0	0	0.5	0.571428571	0.928571429	0.9	0.125
2454_OG5_130774_4 - EUKARYOTES_YOR340C	YOR340C	RPA43 - RNA polymerase I subunit A43	1	0	0	0.375	0.523809524	1	1	0.125
2455_OG5_127582_4 - EUKARYOTES_YOR093C	YOR093C	YOR093C - Putative protein of unknown function; deletion causes sensitivity to unfolded protein response-inducing agents	1	0	0.194444444	0.375	0.714285714	1	0.8	0.125
2456_OG5_129878_4 - EUKARYOTES_YOR339C	YOR339C	"UBC11 - Ubiquitin-conjugating enzyme most similar in sequence to Xenopus ubiquitin-conjugating enzyme E2-C, but not a true functional homolog of this E2; unlike E2-C, not required for the degradation of mitotic cyclin Clb2"	1	0	0	0.75	0.666666667	0.857142857	0.6	0.25
2457_OG5_129876_4 - EUKARYOTES_YAR008W	YAR008W	"SEN34 - Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen34p contains the active site for tRNA 3' splice site cleavage and has similarity to Sen2p and to Archaeal tRNA splicing endonuclease"	1	0.1875	0	0.25	0.80952381	0.857142857	0.95	0.0625
2458_OG5_129488_4 - EUKARYOTES_YDR178W	YDR178W	"SDH4 - Membrane anchor subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain"	1	0	0	0.25	0.80952381	0.857142857	0.95	0.125
2459_OG5_129488_4 - EUKARYOTES_YLR164W	YLR164W	"YLR164W - Mitochondrial inner membrane protein of unknown function; similar to Tim18p and Sdh4p; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner"	1	0	0	0.25	0.80952381	0.857142857	0.95	0.125
2460_OG5_129488_4 - EUKARYOTES_YOR297C	YOR297C	TIM18 - Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; may mediate assembly or stability of the complex	1	0	0	0.25	0.80952381	0.857142857	0.95	0.125
2461_OG5_129312_4 - EUKARYOTES_YNL024C-A	YNL024C-A	KSH1 - Essential protein suggested to function early in the secretory pathway; inviability is suppressed by overexpression of Golgi protein Tvp23p; ortholog of human Kish	1	0	0	0.875	0.476190476	0.714285714	0.8	0.625
2462_OG5_131207_4 - EUKARYOTES_YMR153W	YMR153W	"NUP53 - Subunit of the nuclear pore complex (NPC), interacts with karyopherin Kap121p or with Nup170p via overlapping regions of Nup53p, involved in activation of the spindle checkpoint mediated by the Mad1p-Mad2p complex"	1	0	0	1	0.761904762	1	0.1	0.125
2463_OG5_129948_4 - EUKARYOTES_YNL039W	YNL039W	"BDP1 - Essential subunit of RNA polymerase III transcription factor (TFIIIB), which is involved in transcription of genes encoding tRNAs, 5S rRNA, U6 snRNA, and other small RNAs"	1	0	0	0.375	0.761904762	0.857142857	0.85	0.3125
2464_OG5_131019_4 - EUKARYOTES_YDR004W	YDR004W	RAD57 - Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad55p	1	0	0	0.625	0.333333333	0.928571429	0.95	0.125
2465_OG5_130778_4 - EUKARYOTES_YDR493W	YDR493W	MZM1 - Mitochondrial matrix protein with a role in maintaining the labile mitochondrial zinc pool; null mutant has a respiratory growth defect and an elevated frequency of mitochondrial genome loss; overexpression causes cell cycle delay or arrest	1	0	0	0.75	0.571428571	0.714285714	0.8	0.125
2466_OG5_128101_4 - EUKARYOTES_YJR126C	YJR126C	VPS70 - Protein of unknown function involved in vacuolar protein sorting	1	0	0	0.5	0.333333333	1	1	0.125
2467_OG5_129517_4 - EUKARYOTES_YCR059C	YCR059C	"YIH1 - Protein that inhibits activation of Gcn2p, an eIF2 alpha subunit protein kinase, by competing for Gcn1p binding, thus impacting gene expression in response to starvation; has sequence and functional similarity to the mouse IMPACT gene"	1	0	0	0.5	0.523809524	0.857142857	0.95	0.5
2468_OG5_130738_4 - EUKARYOTES_YBR273C	YBR273C	UBX7 - UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p	1	0	0	0.625	0.523809524	0.928571429	0.75	0.0625
2469_OG5_130738_4 - EUKARYOTES_YJL048C	YJL048C	"UBX6 - UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p, transcription is repressed when cells are grown in media containing inositol and choline"	1	0	0	0.625	0.523809524	0.928571429	0.75	0.0625
2470_OG5_129607_4 - EUKARYOTES_YDR469W	YDR469W	"SDC1 - Subunit of the COMPASS (Set1C) complex, which methylates lysine 4 of histone H3 and is required in chromatin silencing at telomeres; contains a Dpy-30 domain that mediates interaction with Bre2p; similar to C. elegans and human DPY-30"	1	0	0	0.5	0.714285714	0.857142857	0.75	0.375
2471_OG5_130533_4 - EUKARYOTES_YDL193W	YDL193W	"NUS1 - Putative prenyltransferase, required for cell viability; proposed to be involved in protein trafficking because tet-repressible mutant shows accumulation of hypoglycosylated forms of CPY"	1	0	0	0.375	0.666666667	0.928571429	0.85	0.0625
2472_OG5_129125_4 - EUKARYOTES_YDR151C	YDR151C	"CTH1 - Member of the CCCH zinc finger family; has similarity to mammalian Tis11 protein, which activates transcription and also has a role in mRNA degradation; may function with Tis11p in iron homeostasis"	1	0	0	0.75	0.80952381	0.857142857	0.4	0.3125
2473_OG5_129125_4 - EUKARYOTES_YLR136C	YLR136C	TIS11 - mRNA-binding protein expressed during iron starvation; binds to a sequence element in the 3'-untranslated regions of specific mRNAs to mediate their degradation; involved in iron homeostasis	1	0	0	0.75	0.80952381	0.857142857	0.4	0.3125
2474_OG5_132021_4 - EUKARYOTES_YCR014C	YCR014C	"POL4 - DNA polymerase IV, undergoes pair-wise interactions with Dnl4p-Lif1p and Rad27p to mediate repair of DNA double-strand breaks by non-homologous end joining (NHEJ); homologous to mammalian DNA polymerase beta"	1	0	0	1	0.285714286	0.928571429	0.6	0
2475_OG5_129959_4 - EUKARYOTES_YGL111W	YGL111W	"NSA1 - Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis"	1	0	0	0.75	0.80952381	0.785714286	0.45	0.375
2476_OG5_130175_4 - EUKARYOTES_YNL202W	YNL202W	"SPS19 - Peroxisomal 2,4-dienoyl-CoA reductase, auxiliary enzyme of fatty acid beta-oxidation; homodimeric enzyme required for growth and sporulation on petroselineate medium; expression induced during late sporulation and in the presence of oleate"	1	0	0.055555556	0.75	0.238095238	0.857142857	0.95	0.1875
2477_OG5_130124_4 - EUKARYOTES_YHR143W-A	YHR143W-A	"RPC10 - RNA polymerase subunit ABC10-alpha, found in RNA polymerase complexes I, II, and III"	1	0	0	0.625	0.666666667	0.642857143	0.85	0.375
2478_OG5_130862_4 - EUKARYOTES_YPL134C	YPL134C	"ODC1 - Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for lysine and glutamate biosynthesis and lysine catabolism; suppresses, in multicopy, an fmc1 null mutation"	1	0	0	0.375	0.523809524	0.928571429	0.95	0
2479_OG5_130862_4 - EUKARYOTES_YOR222W	YOR222W	"ODC2 - Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for use in lysine and glutamate biosynthesis and in lysine catabolism"	1	0	0	0.375	0.523809524	0.928571429	0.95	0
2480_OG5_130853_4 - EUKARYOTES_YDR511W	YDR511W	"ACN9 - Protein of the mitochondrial intermembrane space, required for acetate utilization and gluconeogenesis; has orthologs in higher eukaryotes"	1	0	0	0.375	0.666666667	0.785714286	0.95	0.0625
2481_OG5_128742_4 - EUKARYOTES_YEL064C	YEL064C	"AVT2 - Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters"	1	0	0	0.375	0.571428571	0.928571429	0.9	0.375
2482_OG5_130232_4 - EUKARYOTES_YER019W	YER019W	"ISC1 - Mitochondrial membrane localized inositol phosphosphingolipid phospholipase C, hydrolyzes complex sphingolipids to produce ceramide; activated by phosphatidylserine, cardiolipin, and phosphatidylglycerol; mediates Na+ and Li+ halotolerance"	1	0	0	0.25	0.666666667	0.857142857	1	0.125
2483_OG5_130269_4 - EUKARYOTES_YGL150C	YGL150C	"INO80 - ATPase and nucleosome spacing factor, subunit of complex containing actin and actin-related proteins that has chromatin remodeling activity and 3' to 5' DNA helicase activity in vitro; has a role in modulating stress gene transcription"	1	0	0	0.25	0.666666667	0.857142857	1	0.25
2484_OG5_130553_4 - EUKARYOTES_YBL009W	YBL009W	ALK2 - Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; similar to Alk1p and to mammalian haspins	1	0	0	1	0.571428571	0.5	0.7	0.1875
2485_OG5_130304_4 - EUKARYOTES_YDR139C	YDR139C	"RUB1 - Ubiquitin-like protein with similarity to mammalian NEDD8; conjugation (neddylation) substrates include the cullins Cdc53p, Rtt101p, and Cul3p; activated by Ula1p and Uba3p (E1 enzyme pair); conjugation mediated by Ubc12p (E2 enzyme)"	1	0	0	0.375	0.80952381	0.785714286	0.8	0.0625
2486_OG5_129204_4 - EUKARYOTES_YCL005W-A	YCL005W-A	VMA9 - Vacuolar H+ ATPase subunit e of the V-ATPase V0 subcomplex; essential for vacuolar acidification; interacts with the V-ATPase assembly factor Vma21p in the ER; involved in V0 biogenesis	1	0	0	0.625	0.666666667	0.928571429	0.55	0.5625
2487_OG5_130934_4 - EUKARYOTES_YGL100W	YGL100W	"SEH1 - Nuclear pore protein of the conserved Nup84p complex (Nup84p, Nup85p, Nup120p, Nup145p, and Seh1p); part of the SEA (Seh1-associated) complex, a coatamer-related complex that associates dynamically with the vacuole; homologous to Sec13p"	1	0	0	0.375	0.80952381	0.928571429	0.65	0.125
2488_OG5_129833_4 - EUKARYOTES_YER134C	YER134C	"YER134C - Magnesium-dependent acid phosphatase, member of the haloacid dehalogenase superfamily; non-essential gene"	1	0.1875	0	1	0.238095238	0.571428571	0.95	0.3125
2489_OG5_130657_4 - EUKARYOTES_YLR242C	YLR242C	ARV1 - Protein functioning in transport of glycosylphosphatidylinositol intermediates into ER lumen; required for normal intracellular sterol distribution; human ARV1 required for normal cholesterol and bile acid homeostasis; similar to Nup120p	1	0	0	0.5	0.523809524	0.928571429	0.8	0.125
2490_OG5_130179_4 - EUKARYOTES_YHR140W	YHR140W	YHR140W - Putative integral membrane protein of unknown function	1	0	0	0.25	0.619047619	0.928571429	0.95	0.0625
2491_OG5_130695_4 - EUKARYOTES_YDL207W	YDL207W	"GLE1 - Cytoplasmic nucleoporin required for polyadenylated RNA export; not essential for protein import; contains a nuclear export signal; when bound to inositol hexakisphosphate (IP6), functions as an activator for the ATPase activity of Dbp1p at the nuclear pore complex during mRNA export"	1	0	0	0.875	0.571428571	1	0.3	0.3125
2492_OG5_129890_4 - EUKARYOTES_YCR009C	YCR009C	"RVS161 - Amphiphysin-like lipid raft protein; interacts with Rvs167p and regulates polarization of the actin cytoskeleton, endocytosis, cell polarity, cell fusion and viability following starvation or osmotic stress"	1	0	0	0.25	0.476190476	1	1	0
2493_OG5_131665_4 - EUKARYOTES_YGR183C	YGR183C	"QCR9 - Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex"	1	0	0	1	0.476190476	0.428571429	0.8	0
2494_OG5_128154_4 - EUKARYOTES_YJR110W	YJR110W	"YMR1 - Phosphatidylinositol 3-phosphate (PI3P) phosphatase; involved in various protein sorting pathways, including CVT targeting and endosome to vacuole transport; has similarity to the conserved myotubularin dual specificity phosphatase family"	1	0	0	0.5	0.904761905	1	0.3	0.25
2495_OG5_131219_4 - EUKARYOTES_YJL187C	YJL187C	SWE1 - Protein kinase that regulates the G2/M transition by inhibition of Cdc28p kinase activity; localizes to the nucleus and to the daughter side of the mother-bud neck; homolog of S. pombe Wee1p; potential Cdc28p substrate	1	0	0	0.375	0.571428571	0.857142857	0.9	0
2496_OG5_129543_4 - EUKARYOTES_YHR201C	YHR201C	"PPX1 - Exopolyphosphatase, hydrolyzes inorganic polyphosphate (poly P) into Pi residues; located in the cytosol, plasma membrane, and mitochondrial matrix"	1	0	0	0.25	0.571428571	0.928571429	0.95	0.375
2497_OG5_131331_4 - EUKARYOTES_YDL115C	YDL115C	"IWR1 - RNA polymerase II transport factor, conserved from yeast to humans; involved in both basal and regulated transcription from RNA polymerase II (RNAP II) promoters, but not itself a transcription factor; interacts with most of the RNAP II subunits; nucleo-cytoplasmic shuttling protein; deletion causes hypersensitivity to K1 killer toxin"	1	0	0	0.625	0.619047619	1	0.45	0
2498_OG5_131524_4 - EUKARYOTES_YLR003C	YLR003C	CMS1 - Subunit of U3-containing 90S preribosome processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit; overexpression rescues supressor mutant of mcm10; null mutant is viable	1	0	0	0.5	0.238095238	1	0.95	0.0625
2499_OG5_131592_4 - EUKARYOTES_YNL260C	YNL260C	YNL260C - Putative protein of unknown function with similarity to a human protein overexpressed in oral cancers; essential gene with defects in anaerobic and filamentous growth; localizes to the nucleus and cytoplasm	1	0	0	0.875	0.476190476	0.785714286	0.55	0.0625
2500_OG5_128747_4 - EUKARYOTES_YCR011C	YCR011C	ADP1 - Putative ATP-dependent permease of the ABC transporter family of proteins	1	0.0625	0.055555556	0.75	0.80952381	0.214285714	0.9	0.4375
2501_OG5_129882_4 - EUKARYOTES_YDL112W	YDL112W	"TRM3 - 2'-O-ribose methyltransferase, catalyzes the ribose methylation of the guanosine nucleotide at position 18 of tRNAs"	1	0	0	0.75	0.666666667	0.857142857	0.4	0.25
2502_OG5_130935_4 - EUKARYOTES_YCR066W	YCR066W	"RAD18 - E3 ubiqutin ligase, forms heterodimer with Rad6p to monoubiquitinate PCNA-K164; heterodimer binds single-stranded DNA and has single-stranded DNA dependent ATPase activity; required for postreplication repair"	1	0	0	0.5	0.380952381	0.785714286	1	0.0625
2503_OG5_131259_4 - EUKARYOTES_YDR026C	YDR026C	"YDR026C - Protein of unknown function that may interact with ribosomes, based on co-purification experiments; Myb-like DNA-binding protein that may bind to the Ter region of rDNA; interacts physically with Fob1p"	1	0	0	0.625	0.285714286	1	0.75	0
2504_OG5_131259_4 - EUKARYOTES_YBR049C	YBR049C	REB1 - RNA polymerase I enhancer binding protein; DNA binding protein which binds to genes transcribed by both RNA polymerase I and RNA polymerase II; required for termination of RNA polymerase I transcription	1	0	0	0.625	0.285714286	1	0.75	0
2505_OG5_131332_4 - EUKARYOTES_YKL086W	YKL086W	"SRX1 - Sulfiredoxin, contributes to oxidative stress resistance by reducing cysteine-sulfinic acid groups in the peroxiredoxin Tsa1p, which is formed upon exposure to oxidants; conserved in higher eukaryotes"	1	0	0	0.75	0.428571429	0.928571429	0.55	0
2506_OG5_131717_4 - EUKARYOTES_YDL150W	YDL150W	RPC53 - RNA polymerase III subunit C53	1	0	0	0.75	0.523809524	0.928571429	0.45	0.125
2507_OG5_128192_4 - EUKARYOTES_YHR031C	YHR031C	RRM3 - DNA helicase involved in rDNA replication and Ty1 transposition; relieves replication fork pauses at telomeric regions; structurally and functionally related to Pif1p	1	0	0.027777778	0.25	0.571428571	0.928571429	0.9	0.4375
2508_OG5_129667_4 - EUKARYOTES_YLL014W	YLL014W	EMC6 - Member of a transmembrane complex required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response	1	0	0	0.625	0.666666667	0.857142857	0.5	0.4375
2509_OG5_130022_4 - EUKARYOTES_YHR034C	YHR034C	"PIH1 - Protein of unresolved function; may function in protein folding and/or rRNA processing, interacts with a chaperone (Hsp82p), two chromatin remodeling factors (Rvb1p, Rvb2p) and two rRNA processing factors (Rrp43p, Nop58p)"	1	0	0	0.625	0.666666667	0.857142857	0.5	0.3125
2510_OG5_130096_4 - EUKARYOTES_YCL055W	YCL055W	"KAR4 - Transcription factor required for gene regulation in response to pheromones; also required during meiosis; exists in two forms, a slower-migrating form more abundant during vegetative growth and a faster-migrating form induced by pheromone"	1	0	0	0.5	0.523809524	1	0.6	0.3125
2511_OG5_130497_4 - EUKARYOTES_YBR183W	YBR183W	"YPC1 - Alkaline ceramidase that also has reverse (CoA-independent) ceramide synthase activity, catalyzes both breakdown and synthesis of phytoceramide; overexpression confers fumonisin B1 resistance"	1	0	0	0.5	0.238095238	0.928571429	0.95	0.0625
2512_OG5_130497_4 - EUKARYOTES_YPL087W	YPL087W	"YDC1 - Alkaline dihydroceramidase, involved in sphingolipid metabolism; preferentially hydrolyzes dihydroceramide to a free fatty acid and dihydrosphingosine; has a minor reverse activity"	1	0	0	0.5	0.238095238	0.928571429	0.95	0.0625
2513_OG5_129953_4 - EUKARYOTES_YGR232W	YGR232W	"NAS6 - Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); ortholog of human oncoprotein gankyrin, which interacts with the Rb tumor suppressor and CDK4/6"	1	0	0	0.375	0.666666667	0.857142857	0.7	0.3125
2514_OG5_128667_4 - EUKARYOTES_YIL072W	YIL072W	HOP1 - Meiosis-specific DNA binding protein that displays Red1p dependent localization to the unsynapsed axial-lateral elements of the synaptonemal complex; required for homologous chromosome synapsis and chiasma formation	1	0	0	0.625	0.333333333	0.928571429	0.7	0.6875
2515_OG5_130337_4 - EUKARYOTES_YLR348C	YLR348C	"DIC1 - Mitochondrial dicarboxylate carrier, integral membrane protein, catalyzes a dicarboxylate-phosphate exchange across the inner mitochondrial membrane, transports cytoplasmic dicarboxylates into the mitochondrial matrix"	1	0	0	0.25	0.619047619	0.857142857	0.85	0.0625
2516_OG5_128779_4 - EUKARYOTES_YLL062C	YLL062C	"MHT1 - S-methylmethionine-homocysteine methyltransferase, functions along with Sam4p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio"	1	0	0.083333333	0.625	0.714285714	0.285714286	0.95	0.4375
2517_OG5_128779_4 - EUKARYOTES_YPL273W	YPL273W	"SAM4 - S-adenosylmethionine-homocysteine methyltransferase, functions along with Mht1p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio"	1	0	0.083333333	0.625	0.714285714	0.285714286	0.95	0.4375
2518_OG5_130427_4 - EUKARYOTES_YPL162C	YPL162C	YPL162C - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of vacuole with cell cycle-correlated morphology	1	0	0	0.25	0.523809524	1	0.8	0.1875
2519_OG5_131002_4 - EUKARYOTES_YDR289C	YDR289C	"RTT103 - Protein that interacts with exonuclease Rat1p and Rai1p and plays a role in transcription termination by RNA polymerase II, has an RPR domain (carboxy-terminal domain interacting domain); also involved in regulation of Ty1 transposition"	1	0	0	0.75	0.761904762	0.857142857	0.2	0.3125
2520_OG5_130002_4 - EUKARYOTES_YER074W-A	YER074W-A	"YOS1 - Integral membrane protein required for ER to Golgi transport; localized to the Golgi, the ER, and COPII vesicles; interacts with Yip1p and Yif1p"	1	0	0	0.75	0.666666667	0.428571429	0.7	0.3125
2521_OG5_129794_4 - EUKARYOTES_YCL064C	YCL064C	"CHA1 - Catabolic L-serine (L-threonine) deaminase, catalyzes the degradation of both L-serine and L-threonine; required to use serine or threonine as the sole nitrogen source, transcriptionally induced by serine and threonine"	1	0	0	0.375	0.285714286	0.928571429	0.95	0.0625
2522_OG5_131764_4 - EUKARYOTES_YBL059C-A	YBL059C-A	CMC2 - Protein of the mitochondrial intermembrane space with a role in respiratory chain complex assembly or maintenance; contains twin Cx9C motifs that can form coiled coil-helix-coiled-coil helix fold	1	0	0	0.5	0.380952381	0.785714286	0.85	0
2523_OG5_132597_4 - EUKARYOTES_YJL013C	YJL013C	"MAD3 - Subunit of the spindle-assembly checkpoint complex, which delays anaphase onset in cells with defects in mitotic spindle assembly; pseudosubstrate inhibitor of APC(Cdc20), the anaphase promoting complex involved in securin (Pds1p) turnover"	1	0	0	1	0.428571429	0.785714286	0.3	0.0625
2524_OG5_130942_4 - EUKARYOTES_YLR205C	YLR205C	"HMX1 - ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants"	1	0	0.055555556	0.375	0.476190476	1	0.65	0.0625
2525_OG5_131652_4 - EUKARYOTES_YLR318W	YLR318W	"EST2 - Reverse transcriptase subunit of the telomerase holoenzyme, essential for telomerase core catalytic activity, involved in other aspects of telomerase assembly and function; mutations in human homolog are associated with aplastic anemia"	1	0	0	0.625	0.285714286	0.857142857	0.7	0.1875
2526_OG5_131683_4 - EUKARYOTES_YHR060W	YHR060W	"VMA22 - Peripheral membrane protein that is required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the yeast endoplasmic reticulum (ER)"	1	0	0	0.625	0.476190476	0.714285714	0.65	0.0625
2527_OG5_130534_4 - EUKARYOTES_YKL053C-A	YKL053C-A	MDM35 - Mitochondrial intermembrane space protein; mutation affects mitochondrial distribution and morphology; contains twin cysteine-x9-cysteine motifs	1	0	0	0.25	0.619047619	0.785714286	0.8	0.1875
2528_OG5_130154_4 - EUKARYOTES_YJR055W	YJR055W	"HIT1 - Protein of unknown function, required for growth at high temperature"	1	0	0	0.375	0.666666667	0.857142857	0.55	0.375
2529_OG5_130333_4 - EUKARYOTES_YER005W	YER005W	"YND1 - Apyrase with wide substrate specificity, helps prevent inhibition of glycosylation by hydrolyzing nucleoside tri- and diphosphates that inhibit glycotransferases; partially redundant with Gda1p; mediates adenovirus E4orf4-induced toxicity"	1	0	0	0.25	0.238095238	0.928571429	1	0.125
2530_OG5_129451_4 - EUKARYOTES_YJL172W	YJL172W	CPS1 - Vacuolar carboxypeptidase yscS; expression is induced under low-nitrogen conditions	1	0	0.083333333	0.25	0.333333333	0.928571429	0.9	0
2531_OG5_130213_4 - EUKARYOTES_YLR262C-A	YLR262C-A	"TMA7 - Protein of unknown that associates with ribosomes; null mutant exhibits translation defects, altered polyribosome profiles, and resistance to the translation inhibitor anisomcyin"	1	0	0	0.5	0.523809524	0.714285714	0.65	0.25
2532_OG5_131560_4 - EUKARYOTES_YOR149C	YOR149C	"SMP3 - Alpha 1,2-mannosyltransferase involved in glycosyl phosphatidyl inositol (GPI) biosynthesis; required for addition of the fourth, side branching mannose to the GPI core structure"	1	0	0	0.25	0.619047619	0.714285714	0.8	0.0625
2533_OG5_131070_4 - EUKARYOTES_YEL038W	YEL038W	"UTR4 - Protein with sequence similarity to 2,3-diketo-5-methylthiopentyl-1-phosphate enolase-phosphatases, involved in methionine salvage; found in both the cytoplasm and nucleus"	1	0	0.083333333	0.25	0.571428571	1	0.55	0.0625
2534_OG5_131708_4 - EUKARYOTES_YDL037C	YDL037C	"BSC1 - Protein of unconfirmed function, similar to cell surface flocculin Muc1p; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression"	1	0	0	0.625	0.523809524	0.714285714	0.5	0.1875
2535_OG5_130672_4 - EUKARYOTES_YIL102C-A	YIL102C-A	"YIL102C-A - Putative protein of unknown function, identified based on comparisons of the genome sequences of six Saccharomyces species"	1	0	0	0.5	0.333333333	0.785714286	0.7	0.25
2536_OG5_131427_4 - EUKARYOTES_YEL019C	YEL019C	MMS21 - SUMO ligase involved in chromosomal organization and DNA repair; essential subunit of the Mms21-Smc5-Smc6 complex; mutants are sensitive to methyl methanesulfonate and show increased spontaneous mutation and mitotic recombination	1	0	0	0.5	0.476190476	0.857142857	0.4	0.125
2537_OG5_132069_4 - EUKARYOTES_YHR116W	YHR116W	"COX23 - Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis, essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs"	1	0	0	0.5	0.333333333	0.642857143	0.75	0
2538_OG5_131522_4 - EUKARYOTES_YMR244C-A	YMR244C-A	YMR244C-A - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced in response to the DNA-damaging agent MMS; YMR244C-A is not an essential gene	1	0	0	0.25	0.428571429	0.642857143	0.9	0.0625
2539_OG5_132464_4 - EUKARYOTES_YOL086W-A	YOL086W-A	"YOL086W-A - Putative protein of unknown function; mutant in a srs2 mutant background displays MMS hypersensitivity; ortholog of human MHF1, a component of the Fanconi anemia (FA) complex that is involved in maintaining genome stability"	1	0	0	0.625	0.238095238	0.714285714	0.6	0.1875
2540_OG5_132556_4 - EUKARYOTES_YJR100C	YJR100C	AIM25 - Putative protein of unknown function; non-tagged protein is detected in purified mitochondria in high-throughput studies; similar to murine NOR1; null mutant is viable and displays elevated frequency of mitochondrial genome loss	1	0	0	0.75	0.285714286	0.285714286	0.85	0
2541_OG5_130081_4 - EUKARYOTES_YPL223C	YPL223C	"GRE1 - Hydrophilin of unknown function; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway"	1	0	0.027777778	0.75	0.380952381	0.714285714	0.3	0.25
2542_OG5_129736_4 - EUKARYOTES_YER175C	YER175C	"TMT1 - Trans-aconitate methyltransferase, cytosolic enzyme that catalyzes the methyl esterification of 3-isopropylmalate, an intermediate of the leucine biosynthetic pathway, and trans-aconitate, which inhibits the citric acid cycle"	1	0.0625	0.055555556	0.625	0.238095238	0.5	0.75	0
2543_OG5_129736_4 - EUKARYOTES_YHR209W	YHR209W	CRG1 - mRNA binding protein and putative S-adenosylmethionine-dependent methyltransferase; mediates cantharidin resistance	1	0.0625	0.055555556	0.625	0.238095238	0.5	0.75	0
2544_OG5_132789_4 - EUKARYOTES_YDR387C	YDR387C	"YDR387C - Putative transporter, member of the sugar porter family; YDR387C is not an essential gene"	1	0	0	0.75	0.238095238	0.928571429	0.15	0
2545_OG5_127475_4 - EUKARYOTES_YJL078C	YJL078C	"PRY3 - Cell wall protein with a role in mating efficiency; expression of full-length transcript is daughter cell-specific; in response to alpha factor, a short transcript starting at +452 is expressed and the long form is repressed by Ste12p"	1	0	0	0.625	0.380952381	0.857142857	0.2	0.1875
2546_OG5_130937_4 - EUKARYOTES_YMR311C	YMR311C	"GLC8 - Regulatory subunit of protein phosphatase 1 (Glc7p), involved in glycogen metabolism and chromosome segregation; proposed to regulate Glc7p activity via conformational alteration; ortholog of the mammalian protein phosphatase inhibitor 2"	1	0	0	0.25	0.714285714	0.928571429	0.15	0.5
2547_OG5_127318_4 - EUKARYOTES_YOR360C	YOR360C	"PDE2 - High-affinity cyclic AMP phosphodiesterase, component of the cAMP-dependent protein kinase signaling system, protects the cell from extracellular cAMP, contains readthrough motif surrounding termination codon"	1	0	0.027777778	0.25	0.666666667	1	0.1	0.375
2548_OG5_132211_4 - EUKARYOTES_YMR072W	YMR072W	"ABF2 - Mitochondrial DNA-binding protein involved in mitochondrial DNA replication and recombination, member of HMG1 DNA-binding protein family; activity may be regulated by protein kinase A phosphorylation"	1	0	0	0.5	0.476190476	0.857142857	0.05	0.0625
2549_OG5_133247_4 - EUKARYOTES_YNL024C	YNL024C	YNL024C - Putative protein of unknown function with seven beta-strand methyltransferase motif; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL024C is not an essential gene	1	0	0.055555556	0.5	0.238095238	0.928571429	0.2	0
2550_OG5_134437_4 - EUKARYOTES_YMR194C-B	YMR194C-B	CMC4 - Protein that localizes to the mitochondrial intermembrane space via the Mia40p-Erv1p system; contains twin cysteine-x(9)-cysteine motifs	1	0	0	0.25	0.285714286	0.357142857	0.6	0
2551_OG5_132246_4 - EUKARYOTES_YKR102W	YKR102W	"FLO10 - Lectin-like protein with similarity to Flo1p, thought to be involved in flocculation"	1	0	0.027777778	0.375	0.285714286	0.214285714	0.2	0.1875
2552_OG5_128696_5 - ANIMALS + FUNGI_YLL040C	YLL040C	"VPS13 - Protein of unknown function; heterooligomeric or homooligomeric complex; peripherally associated with membranes; homologous to human COH1; involved in sporulation, vacuolar protein sorting and protein-Golgi retention"	1	0	0	0	0.952380952	1	1	0.125
2553_OG5_128984_5 - ANIMALS + FUNGI_YDR460W	YDR460W	"TFB3 - Subunit of TFIIH and nucleotide excision repair factor 3 complexes, involved in transcription initiation, required for nucleotide excision repair; ring finger protein similar to mammalian CAK and TFIIH subunit"	1	0	0	0	0.952380952	1	1	0.6875
2554_OG5_127124_5 - ANIMALS + FUNGI_YHL007C	YHL007C	"STE20 - Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family; involved in pheromone response, pseudohyphal/invasive growth, vacuole inheritance, down-regulation of sterol uptake; GBB motif binds Ste4p"	1	0	0	0	0.904761905	1	1	0.25
2555_OG5_127124_5 - ANIMALS + FUNGI_YNL298W	YNL298W	"CLA4 - Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p"	1	0	0	0	0.904761905	1	1	0.25
2556_OG5_127124_5 - ANIMALS + FUNGI_YOL113W	YOL113W	SKM1 - Member of the PAK family of serine/threonine protein kinases with similarity to Ste20p and Cla4p; involved in down-regulation of sterol uptake; proposed to be a downstream effector of Cdc42p during polarized growth	1	0	0	0	0.904761905	1	1	0.25
2557_OG5_128325_5 - ANIMALS + FUNGI_YGR163W	YGR163W	GTR2 - Putative GTP binding protein that negatively regulates Ran/Tc4 GTPase cycle; activates transcription; subunit of EGO and GSE complexes; required for sorting of Gap1p; localizes to cytoplasm and to chromatin; homolog of human RagC and RagD	1	0	0	0	0.904761905	1	1	0.5625
2558_OG5_129933_5 - ANIMALS + FUNGI_YEL062W	YEL062W	NPR2 - Subunit of the conserved Npr2/3 complex that mediates downregulation of TORC1 activity upon amino acid limitation; subunit of SEA (Seh1-associated) complex; homolog of human NPRL2; target of Grr1p; required for growth on urea and proline	1	0	0	0	0.904761905	1	1	0.125
2559_OG5_126672_5 - ANIMALS + FUNGI_YKL129C	YKL129C	"MYO3 - One of two type I myosins; localizes to actin cortical patches; deletion of MYO3 has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization"	1	0	0	0	0.857142857	1	1	0.6875
2560_OG5_126672_5 - ANIMALS + FUNGI_YMR109W	YMR109W	"MYO5 - One of two type I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization"	1	0	0	0	0.857142857	1	1	0.6875
2561_OG5_127131_5 - ANIMALS + FUNGI_YLR433C	YLR433C	"CNA1 - Calcineurin A; one isoform (the other is CMP2) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1"	1	0	0	0	0.857142857	1	1	0.625
2562_OG5_127131_5 - ANIMALS + FUNGI_YML057W	YML057W	"CMP2 - Calcineurin A; one isoform (the other is CNA1) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1"	1	0	0	0	0.857142857	1	1	0.625
2563_OG5_128577_5 - ANIMALS + FUNGI_YBR192W	YBR192W	RIM2 - Mitochondrial pyrimidine nucleotide transporter; imports pyrimidine nucleoside triphosphates and exports pyrimidine nucleoside monophosphates; member of the mitochondrial carrier family	1	0	0	0	0.857142857	1	1	0.3125
2564_OG5_128698_5 - ANIMALS + FUNGI_YJL101C	YJL101C	"GSH1 - Gamma glutamylcysteine synthetase catalyzes the first step in glutathione (GSH) biosynthesis; expression induced by oxidants, cadmium, and mercury"	1	0	0	0	0.857142857	1	1	0.6875
2565_OG5_128105_5 - ANIMALS + FUNGI_YDR017C	YDR017C	"KCS1 - Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase; generation of high energy inositol pyrophosphates by Kcs1p is required for many processes such as vacuolar biogenesis, stress response and telomere maintenance"	1	0	0	0.125	0.857142857	1	1	0.5
2566_OG5_128428_5 - ANIMALS + FUNGI_YBR112C	YBR112C	"CYC8 - General transcriptional co-repressor, acts together with Tup1p; also acts as part of a transcriptional co-activator complex that recruits the SWI/SNF and SAGA complexes to promoters; can form the prion [OCT+]"	1	0	0.027777778	0.125	0.904761905	1	0.95	0.25
2567_OG5_126943_5 - ANIMALS + FUNGI_YLR429W	YLR429W	"CRN1 - Coronin, cortical actin cytoskeletal component that associates with the Arp2p/Arp3p complex to regulate its activity; plays a role in regulation of actin patch assembly"	1	0	0.027777778	0	0.904761905	1	0.95	0.75
2568_OG5_128543_5 - ANIMALS + FUNGI_YCL004W	YCL004W	"PGS1 - Phosphatidylglycerolphosphate synthase, catalyzes the synthesis of phosphatidylglycerolphosphate from CDP-diacylglycerol and sn-glycerol 3-phosphate in the first committed and rate-limiting step of cardiolipin biosynthesis"	1	0	0.166666667	0.125	0.80952381	1	1	0.6875
2569_OG5_129758_5 - ANIMALS + FUNGI_YJR138W	YJR138W	"IML1 - Subunit of the SEA (Seh1-associated) complex, a coatomer-related complex that associates dynamically with the vacuole; has an N-terminal CDC48-like domain and a C-terminal DEP domain; central region is readily accessible to proteases"	1	0	0	0.125	0.80952381	1	1	0.125
2570_OG5_129377_5 - ANIMALS + FUNGI_YGR080W	YGR080W	"TWF1 - Twinfilin, highly conserved actin monomer-sequestering protein involved in regulation of the cortical actin cytoskeleton, composed of two cofilin-like regions, localizes actin monomers to sites of rapid filament assembly"	1	0	0	0	0.80952381	1	1	0.1875
2571_OG5_129996_5 - ANIMALS + FUNGI_YCR088W	YCR088W	"ABP1 - Actin-binding protein of the cortical actin cytoskeleton, important for activation of the Arp2/3 complex that plays a key role actin in cytoskeleton organization"	1	0	0	0	0.80952381	1	1	0.0625
2572_OG5_127596_5 - ANIMALS + FUNGI_YIL048W	YIL048W	NEO1 - Putative aminophospholipid translocase (flippase) involved in endocytosis and vacuolar biogenesis; localizes to endosomes and the Golgi aparatus	1	0	0	0.125	0.857142857	0.928571429	1	0.9375
2573_OG5_130316_5 - ANIMALS + FUNGI_YLR114C	YLR114C	AVL9 - Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms	1	0	0	0	0.857142857	0.928571429	1	0.125
2574_OG5_127228_5 - ANIMALS + FUNGI_YNL079C	YNL079C	"TPM1 - Major isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; acetylated by the NatB complex and acetylated form binds actin most efficiently"	1	0.0625	0.055555556	0.125	0.761904762	1	1	0.0625
2575_OG5_127228_5 - ANIMALS + FUNGI_YIL138C	YIL138C	"TPM2 - Minor isoform of tropomyosin, binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; appears to have distinct and also overlapping functions with Tpm1p"	1	0.0625	0.055555556	0.125	0.761904762	1	1	0.0625
2576_OG5_130001_5 - ANIMALS + FUNGI_YJL080C	YJL080C	"SCP160 - Essential RNA-binding G protein effector of mating response pathway, mainly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins"	1	0	0	0.125	0.761904762	1	1	0.125
2577_OG5_128218_5 - ANIMALS + FUNGI_YDL161W	YDL161W	ENT1 - Epsin-like protein involved in endocytosis and actin patch assembly and functionally redundant with Ent2p; binds clathrin via a clathrin-binding domain motif at C-terminus	1	0	0	0	0.761904762	1	1	0.1875
2578_OG5_128218_5 - ANIMALS + FUNGI_YLR206W	YLR206W	ENT2 - Epsin-like protein required for endocytosis and actin patch assembly and functionally redundant with Ent1p; contains clathrin-binding motif at C-terminus	1	0	0	0	0.761904762	1	1	0.1875
2579_OG5_129335_5 - ANIMALS + FUNGI_YOR035C	YOR035C	"SHE4 - Protein containing a UCS (UNC-45/CRO1/SHE4) domain, binds to myosin motor domains to regulate myosin function; involved in endocytosis, polarization of the actin cytoskeleton, and asymmetric mRNA localization"	1	0	0	0	0.761904762	1	1	0.125
2580_OG5_129663_5 - ANIMALS + FUNGI_YDR372C	YDR372C	VPS74 - Protein required for Golgi localization of glycosyltransferases; binds the cytosolic domains of Golgi glycosyltransferases; binding to PtdIns4P required for Golgi targeting and function; tetramer formation required for function	1	0	0	0	0.761904762	1	1	0.0625
2581_OG5_130182_5 - ANIMALS + FUNGI_YGR284C	YGR284C	"ERV29 - Protein localized to COPII-coated vesicles, involved in vesicle formation and incorporation of specific secretory cargo"	1	0	0	0	0.761904762	1	1	0.0625
2582_OG5_130392_5 - ANIMALS + FUNGI_YHR085W	YHR085W	IPI1 - Essential component of the Rix1 complex (with Rix1p and Ipi3p) that is required for processing of ITS2 sequences from 35S pre-rRNA; Rix1 complex associates with Mdn1p in pre-60S ribosomal particles	1	0	0	0	0.761904762	1	1	0.0625
2583_OG5_130440_5 - ANIMALS + FUNGI_YER093C	YER093C	"TSC11 - Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p), a membrane-associated complex that regulates actin cytoskeletal dynamics during polarized growth and cell wall integrity; involved in sphingolipid metabolism; contains a RasGEFN domain"	1	0	0	0	0.761904762	1	1	0.0625
2584_OG5_129034_5 - ANIMALS + FUNGI_YNL243W	YNL243W	SLA2 - Transmembrane actin-binding protein involved in membrane cytoskeleton assembly and cell polarization; adaptor protein that links actin to clathrin and endocytosis; present in the actin cortical patch of the emerging bud tip; dimer in vivo	1	0	0	0.125	0.80952381	1	0.95	0.0625
2585_OG5_128083_5 - ANIMALS + FUNGI_YDR517W	YDR517W	"GRH1 - Acetylated, cis-golgi localized protein involved in ER to Golgi transport; homolog of human GRASP65; forms a complex with the coiled-coil protein Bug1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes"	1	0	0	0	0.80952381	1	0.95	0.75
2586_OG5_128433_5 - ANIMALS + FUNGI_YDR409W	YDR409W	SIZ1 - SUMO/Smt3 ligase that promotes the attachment of sumo (Smt3p; small ubiquitin-related modifier) to proteins; binds Ubc9p and may bind septins; specifically required for sumoylation of septins in vivo; localized to the septin ring	1	0	0	0	0.80952381	1	0.95	0.1875
2587_OG5_129388_5 - ANIMALS + FUNGI_YNL127W	YNL127W	"FAR11 - Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far8p, Far9p, and Far10p; has similarity to the N- and C-termini of N. crassa HAM-2"	1	0	0	0	0.80952381	1	0.95	0.125
2588_OG5_128837_5 - ANIMALS + FUNGI_YPR184W	YPR184W	"GDB1 - Glycogen debranching enzyme containing glucanotranferase and alpha-1,6-amyloglucosidase activities, required for glycogen degradation; phosphorylated in mitochondria"	1	0.1875	0.055555556	0	0.80952381	1	0.95	0.375
2589_OG5_129742_5 - ANIMALS + FUNGI_YCR027C	YCR027C	RHB1 - Putative Rheb-related GTPase involved in regulating canavanine resistance and arginine uptake; member of the Ras superfamily of G-proteins	1	0	0	0	0.857142857	1	0.9	0.0625
2590_OG5_129226_5 - ANIMALS + FUNGI_YFL027C	YFL027C	"GYP8 - GTPase-activating protein for yeast Rab family members; Ypt1p is the preferred in vitro substrate but also acts on Sec4p, Ypt31p and Ypt32p; involved in the regulation of ER to Golgi vesicle transport"	1	0	0	0	0.80952381	0.928571429	1	0.375
2591_OG5_129012_5 - ANIMALS + FUNGI_YDR358W	YDR358W	"GGA1 - Golgi-localized protein with homology to gamma-adaptin, interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner in order to facilitate traffic through the late Golgi"	1	0	0	0.125	0.714285714	1	1	0.0625
2592_OG5_129012_5 - ANIMALS + FUNGI_YHR108W	YHR108W	"GGA2 - Protein that interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner to facilitate traffic through the late Golgi; binds phosphatidylinositol 4-phosphate, which plays a role in TGN localization; has homology to gamma-adaptin"	1	0	0	0.125	0.714285714	1	1	0.0625
2593_OG5_128099_5 - ANIMALS + FUNGI_YPR165W	YPR165W	"RHO1 - GTP-binding protein of the rho subfamily of Ras-like proteins, involved in establishment of cell polarity; regulates protein kinase C (Pkc1p) and the cell wall synthesizing enzyme 1,3-beta-glucan synthase (Fks1p and Gsc2p)"	1	0	0	0	0.714285714	1	1	0.25
2594_OG5_128520_5 - ANIMALS + FUNGI_YHR135C	YHR135C	"YCK1 - Palmitoylated plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck2p in morphogenesis, proper septin assembly, endocytic trafficking; provides an essential function overlapping with that of Yck2p"	1	0	0	0	0.714285714	1	1	0.0625
2595_OG5_128520_5 - ANIMALS + FUNGI_YNL154C	YNL154C	"YCK2 - Palmitoylated plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck1p in morphogenesis, proper septin assembly, endocytic trafficking; provides an essential function overlapping with that of Yck1p"	1	0	0	0	0.714285714	1	1	0.0625
2596_OG5_128681_5 - ANIMALS + FUNGI_YDL072C	YDL072C	YET3 - Protein of unknown function; YET3 null mutant decreases the level of secreted invertase; homolog of human BAP31 protein	1	0	0	0	0.857142857	0.857142857	1	0.25
2597_OG5_128681_5 - ANIMALS + FUNGI_YKL065C	YKL065C	"YET1 - Endoplasmic reticulum transmembrane protein; may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein"	1	0	0	0	0.857142857	0.857142857	1	0.25
2598_OG5_129733_5 - ANIMALS + FUNGI_YBR291C	YBR291C	"CTP1 - Mitochondrial inner membrane citrate transporter, member of the mitochondrial carrier family"	1	0	0	0	0.714285714	1	1	0.1875
2599_OG5_129885_5 - ANIMALS + FUNGI_YLR229C	YLR229C	"CDC42 - Small rho-like GTPase, essential for establishment and maintenance of cell polarity; mutants have defects in the organization of actin and septins"	1	0	0	0	0.714285714	1	1	0.0625
2600_OG5_128614_5 - ANIMALS + FUNGI_YHR028C	YHR028C	"DAP2 - Dipeptidyl aminopeptidase, synthesized as a glycosylated precursor; localizes to the vacuolar membrane; similar to Ste13p"	1	0	0.027777778	0	0.714285714	1	1	0.0625
2601_OG5_127561_5 - ANIMALS + FUNGI_YDL114W	YDL114W	YDL114W - Putative protein of unknown function with similarity to acyl-carrier-protein reductases; YDL114W is not an essential gene	1	0.0625	0.055555556	0.125	0.761904762	1	0.95	0.25
2602_OG5_130171_5 - ANIMALS + FUNGI_YNR006W	YNR006W	"VPS27 - Endosomal protein that forms a complex with Hse1p; required for recycling Golgi proteins, forming lumenal membranes and sorting ubiquitinated proteins destined for degradation; has Ubiquitin Interaction Motifs which bind ubiquitin (Ubi4p)"	1	0	0.027777778	0.125	0.761904762	1	0.95	0.0625
2603_OG5_128862_5 - ANIMALS + FUNGI_YLR310C	YLR310C	CDC25 - Membrane bound guanine nucleotide exchange factor (GEF or GDP-release factor); indirectly regulates adenylate cyclase through activation of Ras1p and Ras2p by stimulating the exchange of GDP for GTP; required for progression through G1	1	0	0	0	0.761904762	1	0.95	0.1875
2604_OG5_129195_5 - ANIMALS + FUNGI_YAR035W	YAR035W	"YAT1 - Outer mitochondrial carnitine acetyltransferase, minor ethanol-inducible enzyme involved in transport of activated acyl groups from the cytoplasm into the mitochondrial matrix; phosphorylated"	1	0	0	0	0.761904762	1	0.95	0.25
2605_OG5_129425_5 - ANIMALS + FUNGI_YLR258W	YLR258W	"GSY2 - Glycogen synthase, similar to Gsy1p; expression induced by glucose limitation, nitrogen starvation, heat shock, and stationary phase; activity regulated by cAMP-dependent, Snf1p and Pho85p kinases as well as by the Gac1p-Glc7p phosphatase"	1	0	0	0	0.761904762	1	0.95	0.125
2606_OG5_129425_5 - ANIMALS + FUNGI_YFR015C	YFR015C	"GSY1 - Glycogen synthase with similarity to Gsy2p, the more highly expressed yeast homolog; expression induced by glucose limitation, nitrogen starvation, environmental stress, and entry into stationary phase"	1	0	0	0	0.761904762	1	0.95	0.125
2607_OG5_129465_5 - ANIMALS + FUNGI_YKR058W	YKR058W	"GLG1 - Self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin"	1	0	0	0	0.761904762	1	0.95	0.1875
2608_OG5_129997_5 - ANIMALS + FUNGI_YHL023C	YHL023C	NPR3 - Subunit of the conserved Npr2/3 complex that mediates downregulation of TORC1 activity upon amino acid limitation; subunit of SEA (Seh1-associated) complex; null mutant displays delayed meiotic DNA replication and double-strand break repair	1	0	0	0	0.761904762	1	0.95	0.125
2609_OG5_127740_5 - ANIMALS + FUNGI_YOR271C	YOR271C	"FSF1 - Putative protein, predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis"	1	0	0	0.125	0.80952381	1	0.9	0.4375
2610_OG5_129186_5 - ANIMALS + FUNGI_YHR129C	YHR129C	ARP1 - Actin-related protein of the dynactin complex; required for spindle orientation and nuclear migration; putative ortholog of mammalian centractin	1	0	0	0	0.80952381	1	0.9	0.375
2611_OG5_128470_5 - ANIMALS + FUNGI_YGR184C	YGR184C	"UBR1 - E3 ubiquitin ligase (N-recognin), forms heterodimer with Rad6p to ubiquitinate substrates in the N-end rule pathway; regulates peptide transport via Cup9p ubiquitination; mutation in human UBR1 causes Johansson-Blizzard Syndrome (JBS)"	1	0	0.027777778	0	0.761904762	0.928571429	1	0.125
2612_OG5_128470_5 - ANIMALS + FUNGI_YLR024C	YLR024C	UBR2 - Cytoplasmic ubiquitin-protein ligase (E3); required for ubiquitylation of Rpn4p; mediates formation of a Mub1p-Ubr2p-Rad6p complex	1	0	0.027777778	0	0.761904762	0.928571429	1	0.125
2613_OG5_130076_5 - ANIMALS + FUNGI_YOR269W	YOR269W	"PAC1 - Protein involved in nuclear migration, part of the dynein/dynactin pathway; targets dynein to microtubule tips, which is necessary for sliding of microtubules along bud cortex; synthetic lethal with bni1; homolog of human LIS1"	1	0	0	0	0.857142857	0.928571429	0.9	0.25
2614_OG5_129868_5 - ANIMALS + FUNGI_YKL016C	YKL016C	"ATP7 - Subunit d of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis"	1	0	0	0	0.666666667	1	1	0.125
2615_OG5_130522_5 - ANIMALS + FUNGI_YGR082W	YGR082W	TOM20 - Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; acts as a receptor for incoming precursor proteins	1	0	0	0	0.666666667	1	1	0
2616_OG5_130544_5 - ANIMALS + FUNGI_YOR330C	YOR330C	"MIP1 - Catalytic subunit of the mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; related to human POLG, which has been associated with mitochondrial diseases"	1	0	0	0	0.666666667	1	1	0.0625
2617_OG5_127947_5 - ANIMALS + FUNGI_YGR100W	YGR100W	"MDR1 - Cytoplasmic GTPase-activating protein for Ypt/Rab transport GTPases Ypt6p, Ypt31p and Sec4p; involved in recycling of internalized proteins and regulation of Golgi secretory function"	1	0	0	0.125	0.714285714	1	0.95	0.3125
2618_OG5_129235_5 - ANIMALS + FUNGI_YLR107W	YLR107W	REX3 - RNA exonuclease; required for maturation of the RNA component of RNase MRP; functions redundantly with Rnh70p and Rex2p in processing of U5 snRNA and RNase P RNA; member of RNase D family of exonucleases	1	0	0	0.125	0.714285714	1	0.95	0.1875
2619_OG5_129669_5 - ANIMALS + FUNGI_YPR021C	YPR021C	"AGC1 - Mitochondrial amino acid transporter, acts both as a glutamate uniporter and as an aspartate-glutamate exchanger; involved in nitrogen metabolism and nitrogen compound biosynthesis"	1	0	0	0.125	0.714285714	1	0.95	0.125
2620_OG5_127296_5 - ANIMALS + FUNGI_YER125W	YER125W	"RSP5 - E3 ubiquitin ligase of the NEDD4 family; involved in regulating many cellular processes including MVB sorting, heat shock response, transcription, endocytosis, and ribosome stability; human homolog is involved in Liddle syndrome; mutant tolerates aneuploidy"	1	0	0	0	0.714285714	1	0.95	0.0625
2621_OG5_128932_5 - ANIMALS + FUNGI_YMR154C	YMR154C	RIM13 - Calpain-like cysteine protease involved in proteolytic activation of Rim101p in response to alkaline pH; has similarity to A. nidulans palB	1	0	0	0	0.714285714	1	0.95	0.6875
2622_OG5_129414_5 - ANIMALS + FUNGI_YGR056W	YGR056W	"RSC1 - Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; contains two essential bromodomains, a bromo-adjacent homology (BAH) domain, and an AT hook"	1	0	0	0	0.714285714	1	0.95	0.0625
2623_OG5_129414_5 - ANIMALS + FUNGI_YLR357W	YLR357W	RSC2 - Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; involved in telomere maintenance	1	0	0	0	0.714285714	1	0.95	0.0625
2624_OG5_129523_5 - ANIMALS + FUNGI_YER170W	YER170W	"ADK2 - Mitochondrial adenylate kinase, catalyzes the reversible synthesis of GTP and AMP from GDP and ADP; may serve as a back-up for synthesizing GTP or ADP depending on metabolic conditions; 3' sequence of ADK2 varies with strain background"	1	0	0	0	0.714285714	1	0.95	0.0625
2625_OG5_129713_5 - ANIMALS + FUNGI_YHL002W	YHL002W	"HSE1 - Subunit of the endosomal Vps27p-Hse1p complex required for sorting of ubiquitinated membrane proteins into intralumenal vesicles prior to vacuolar degradation, as well as for recycling of Golgi proteins and formation of lumenal membranes"	1	0	0	0	0.714285714	1	0.95	0.0625
2626_OG5_130266_5 - ANIMALS + FUNGI_YHR051W	YHR051W	"COX6 - Subunit VI of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; expression is regulated by oxygen levels"	1	0	0	0	0.714285714	1	0.95	0.0625
2627_OG5_128024_5 - ANIMALS + FUNGI_YDR122W	YDR122W	KIN1 - Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p	1	0	0.027777778	0	0.714285714	1	0.95	0.25
2628_OG5_128024_5 - ANIMALS + FUNGI_YLR096W	YLR096W	KIN2 - Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin1p	1	0	0.027777778	0	0.714285714	1	0.95	0.25
2629_OG5_129212_5 - ANIMALS + FUNGI_YMR010W	YMR010W	YMR010W - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR010W is not an essential gene; YMR010W mRNA is transcribed with ADI1	1	0	0	0	0.857142857	1	0.8	0.3125
2630_OG5_130423_5 - ANIMALS + FUNGI_YMR294W	YMR294W	"JNM1 - Component of the yeast dynactin complex, consisting of Nip100p, Jnm1p, and Arp1p; required for proper nuclear migration and spindle partitioning during mitotic anaphase B"	1	0	0	0	0.857142857	0.785714286	1	0.125
2631_OG5_130614_5 - ANIMALS + FUNGI_YPL030W	YPL030W	TRM44 - tRNA(Ser) Um(44) 2'-O-methyltransferase; involved in maintaining levels of the tRNA-Ser species tS(CGA) and tS(UGA); conserved among metazoans and fungi but there does not appear to be a homolog in plants; TRM44 is a non-essential gene	1	0	0	0	0.714285714	0.928571429	1	0.0625
2632_OG5_127403_5 - ANIMALS + FUNGI_YNL098C	YNL098C	"RAS2 - GTP-binding protein that regulates the nitrogen starvation response, sporulation, and filamentous growth; farnesylation and palmitoylation required for activity and localization to plasma membrane; homolog of mammalian Ras proto-oncogenes"	1	0	0	0	0.761904762	0.928571429	0.95	0.1875
2633_OG5_127403_5 - ANIMALS + FUNGI_YOR101W	YOR101W	"RAS1 - GTPase involved in G-protein signaling in the adenylate cyclase activating pathway, plays a role in cell proliferation; localized to the plasma membrane; homolog of mammalian RAS proto-oncogenes"	1	0	0	0	0.761904762	0.928571429	0.95	0.1875
2634_OG5_130452_5 - ANIMALS + FUNGI_YPL085W	YPL085W	"SEC16 - COPII vesicle coat protein required for ER transport vesicle budding; Sec16p is bound to the periphery of ER membranes and may act to stabilize initial COPII complexes; interacts with Sec23p, Sec24p and Sec31p"	1	0	0	0.125	0.619047619	1	1	0.125
2635_OG5_128921_5 - ANIMALS + FUNGI_YDR141C	YDR141C	"DOP1 - Golgi-localized, leucine-zipper domain containing protein; involved in endosome to Golgi transport, organization of the ER, establishing cell polarity, and morphogenesis; detected in highly purified mitochondria in high-throughput studies"	1	0	0	0	0.619047619	1	1	0.4375
2636_OG5_129116_5 - ANIMALS + FUNGI_YPL169C	YPL169C	"MEX67 - Poly(A)RNA binding protein involved in nuclear mRNA export, component of the nuclear pore; ortholog of human TAP"	1	0	0	0	0.761904762	0.857142857	1	0.125
2637_OG5_130444_5 - ANIMALS + FUNGI_YPL094C	YPL094C	"SEC62 - Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER"	1	0	0	0	0.619047619	1	1	0.1875
2638_OG5_130606_5 - ANIMALS + FUNGI_YHR004C	YHR004C	"NEM1 - Probable catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme; regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology and sporulation; homolog of the human protein Dullard"	1	0	0	0	0.761904762	0.857142857	1	0.125
2639_OG5_129944_5 - ANIMALS + FUNGI_YOL068C	YOL068C	HST1 - NAD(+)-dependent histone deacetylase; essential subunit of the Sum1p/Rfm1p/Hst1p complex required for ORC-dependent silencing and mitotic repression; non-essential subunit of the Set3C deacetylase complex; involved in telomere maintenance	1	0	0.027777778	0	0.619047619	1	1	0.25
2640_OG5_129944_5 - ANIMALS + FUNGI_YDL042C	YDL042C	"SIR2 - Conserved NAD+ dependent histone deacetylase of the Sirtuin family involved in regulation of lifespan; plays roles in silencing at HML, HMR, telomeres, and the rDNA locus; negatively regulates initiation of DNA replication"	1	0	0.027777778	0	0.619047619	1	1	0.25
2641_OG5_127795_5 - ANIMALS + FUNGI_YOR286W	YOR286W	"RDL2 - Protein with rhodanese activity; contains a rhodanese-like domain similar to Rdl1p, Uba4p, Tum1p, and Ych1p; overexpression causes a cell cycle delay; null mutant displays elevated frequency of mitochondrial genome loss"	1	0	0.027777778	0.125	0.666666667	1	0.95	0.25
2642_OG5_127795_5 - ANIMALS + FUNGI_YOR285W	YOR285W	RDL1 - Protein of unknown function containing a rhodanese-like domain; localized to the mitochondrial outer membrane	1	0	0.027777778	0.125	0.666666667	1	0.95	0.25
2643_OG5_128929_5 - ANIMALS + FUNGI_YGR280C	YGR280C	"PXR1 - Essential protein involved in rRNA and snoRNA maturation; competes with TLC1 RNA for binding to Est2p, suggesting a role in negative regulation of telomerase; human homolog inhibits telomerase; contains a G-patch RNA interacting domain"	1	0	0	0.125	0.80952381	0.857142857	0.95	0.375
2644_OG5_130531_5 - ANIMALS + FUNGI_YPR161C	YPR161C	SGV1 - Cyclin (Bur2p)-dependent protein kinase that functions in transcriptional regulation; phosphorylates the carboxy-terminal domain of Rpo21p and the C-terminal repeat domain of Spt5p; regulated by Cak1p; similar to metazoan CDK9 proteins	1	0	0	0	0.666666667	1	0.95	0.125
2645_OG5_127971_5 - ANIMALS + FUNGI_YDR432W	YDR432W	"NPL3 - RNA-binding protein that promotes elongation, regulates termination, and carries poly(A) mRNA from nucleus to cytoplasm; required for pre-mRNA splicing; dissociation from mRNAs promoted by Mtr10p; phosphorylated by Sky1p in the cytoplasm"	1	0	0.027777778	0.125	0.714285714	1	0.9	0.4375
2646_OG5_130454_5 - ANIMALS + FUNGI_YBR274W	YBR274W	"CHK1 - Serine/threonine kinase and DNA damage checkpoint effector, mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase"	1	0	0	0	0.714285714	1	0.9	0.0625
2647_OG5_129880_5 - ANIMALS + FUNGI_YEL004W	YEL004W	YEA4 - Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter required for cell wall chitin synthesis; localized to the ER	1	0	0	0	0.761904762	1	0.85	0.1875
2648_OG5_130880_5 - ANIMALS + FUNGI_YDR323C	YDR323C	"PEP7 - Multivalent adaptor protein that facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance"	1	0	0	0	0.761904762	1	0.85	0.0625
2649_OG5_130195_5 - ANIMALS + FUNGI_YLR193C	YLR193C	"UPS1 - Mitochondrial intermembrane space protein that regulates mitochondrial cardiolipin levels, null has defects in Mgm1p processing, integrity of mitochondrial inner membrane complexes, and mitochondrial morphology; ortholog of human PRELI"	1	0	0	0	0.666666667	0.928571429	1	0.0625
2650_OG5_130332_5 - ANIMALS + FUNGI_YLR337C	YLR337C	VRP1 - Proline-rich actin-associated protein involved in cytoskeletal organization and cytokinesis; related to mammalian Wiskott-Aldrich syndrome protein (WASP)-interacting protein (WIP)	1	0	0	0	0.666666667	0.928571429	1	0.125
2651_OG5_130882_5 - ANIMALS + FUNGI_YDR128W	YDR128W	"MTC5 - Subunit of the SEA (Seh1-associated) complex, a coatomer-related complex that associates dynamically with the vacuole; has N-terminal WD-40 repeats and a C-terminal RING motif; mtc5 is synthetically sick with cdc13-1"	1	0	0	0	0.666666667	0.928571429	1	0.0625
2652_OG5_129071_5 - ANIMALS + FUNGI_YPL069C	YPL069C	"BTS1 - Geranylgeranyl diphosphate synthase, increases the intracellular pool of geranylgeranyl diphosphate, suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-binding proteins that mediate vesicular traffic"	1	0.0625	0.027777778	0.125	0.714285714	0.928571429	0.95	0.25
2653_OG5_130100_5 - ANIMALS + FUNGI_YDR063W	YDR063W	AIM7 - Protein that interacts with Arp2/3 complex to stimulate actin filament debranching and inhibit actin nucleation; has similarity to Cof1p and also to human glia maturation factor (GMF); null mutant displays elevated mitochondrial genome loss	1	0	0	0	0.714285714	0.928571429	0.95	0.0625
2654_OG5_129336_5 - ANIMALS + FUNGI_YGR152C	YGR152C	"RSR1 - GTP-binding protein of the ras superfamily required for bud site selection, morphological changes in response to mating pheromone, and efficient cell fusion; localized to the plasma membrane; significantly similar to mammalian Rap GTPases"	1	0	0	0	0.80952381	0.928571429	0.85	0.125
2655_OG5_130621_5 - ANIMALS + FUNGI_YML067C	YML067C	"ERV41 - Protein localized to COPII-coated vesicles, forms a complex with Erv46p; involved in the membrane fusion stage of transport; has homology to human ERGIC2 (PTX1) protein"	1	0	0	0	0.571428571	1	1	0.0625
2656_OG5_130049_5 - ANIMALS + FUNGI_YNR031C	YNR031C	"SSK2 - MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway; interacts with Ssk1p, leading to autophosphorylation and activation of Ssk2p which phosphorylates Pbs2p; also mediates actin cytoskeleton recovery from osmotic stress"	1	0	0	0.125	0.619047619	1	0.95	0.0625
2657_OG5_130049_5 - ANIMALS + FUNGI_YCR073C	YCR073C	"SSK22 - MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway; functionally redundant with, and homologous to, Ssk2p; interacts with and is activated by Ssk1p; phosphorylates Pbs2p"	1	0	0	0.125	0.619047619	1	0.95	0.0625
2658_OG5_128739_5 - ANIMALS + FUNGI_YOR367W	YOR367W	"SCP1 - Component of yeast cortical actin cytoskeleton, binds and cross links actin filaments; originally identified by its homology to calponin (contains a calponin-like repeat) but the Scp1p domain structure is more similar to transgelin"	1	0	0	0	0.761904762	1	0.8	0.1875
2659_OG5_130689_5 - ANIMALS + FUNGI_YGR062C	YGR062C	"COX18 - Mitochondrial integral inner membrane protein required for membrane insertion of C-terminus of Cox2p; interacts genetically and physically with Mss2p and Pnt1p; similar to S. cerevisiae Oxa1, N. crassa Oxa2p, and E. coli YidC"	1	0	0	0	0.761904762	1	0.8	0.0625
2660_OG5_129084_5 - ANIMALS + FUNGI_YDR054C	YDR054C	"CDC34 - Ubiquitin-conjugating enzyme (E2) and catalytic subunit of SCF ubiquitin-protein ligase complex (together with Skp1p, Rbx1p, Cdc53p, and an F-box protein) that regulates cell cycle progression by targeting key substrates for degradation"	1	0	0	0	0.80952381	1	0.75	0.3125
2661_OG5_128610_5 - ANIMALS + FUNGI_YLR113W	YLR113W	HOG1 - Mitogen-activated protein kinase involved in osmoregulation; acts via three independent osmosensors; mitophagy-specific regulator; mediates the recruitment and activation of RNA Pol II at Hot1p-dependent promoters; localization regulated by Ptp2p and Ptp3p	1	0	0	0.125	0.619047619	0.928571429	1	0.1875
2662_OG5_129221_5 - ANIMALS + FUNGI_YKL120W	YKL120W	"OAC1 - Mitochondrial inner membrane transporter, transports oxaloacetate, sulfate, thiosulfate, and isopropylmalate; member of the mitochondrial carrier family"	1	0	0	0	0.619047619	0.928571429	1	0.125
2663_OG5_129282_5 - ANIMALS + FUNGI_YAL023C	YAL023C	"PMT2 - Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein Ser/Thr residues; involved in ER quality control; acts in a complex with Pmt1p, can instead interact with Pmt5; target for new antifungal"	1	0	0	0	0.619047619	0.928571429	1	0.1875
2664_OG5_129282_5 - ANIMALS + FUNGI_YGR199W	YGR199W	"PMT6 - Protein O-mannosyltransferase, transfers mannose from dolichyl phosphate-D-mannose to protein serine/threonine residues of secretory proteins; reaction is essential for cell wall rigidity; member of a family of mannosyltransferases"	1	0	0	0	0.619047619	0.928571429	1	0.1875
2665_OG5_129282_5 - ANIMALS + FUNGI_YOR321W	YOR321W	"PMT3 - Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt5p, can instead interact with Pmt1p in some conditions; target for new antifungals"	1	0	0	0	0.619047619	0.928571429	1	0.1875
2666_OG5_130773_5 - ANIMALS + FUNGI_YPL225W	YPL225W	"YPL225W - Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm"	1	0	0	0	0.619047619	0.928571429	1	0.125
2667_OG5_131035_5 - ANIMALS + FUNGI_YBR102C	YBR102C	"EXO84 - Essential protein with dual roles in spliceosome assembly and exocytosis; the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p) mediates polarized targeting of secretory vesicles to active sites of exocytosis"	1	0	0	0	0.666666667	0.928571429	0.95	0.0625
2668_OG5_128876_5 - ANIMALS + FUNGI_YHR132C	YHR132C	"ECM14 - Putative metalloprotease with similarity to the zinc carboxypeptidase family, required for normal cell wall assembly"	1	0	0	0	0.666666667	0.857142857	1	0.0625
2669_OG5_129640_5 - ANIMALS + FUNGI_YHL021C	YHL021C	"AIM17 - Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss"	1	0	0.027777778	0.125	0.571428571	1	0.95	0
2670_OG5_128973_5 - ANIMALS + FUNGI_YLR176C	YLR176C	"RFX1 - Major transcriptional repressor of DNA-damage-regulated genes, recruits repressors Tup1p and Cyc8p to their promoters; involved in DNA damage and replication checkpoint pathway; similar to a family of mammalian DNA binding RFX1-4 proteins"	1	0	0	0	0.619047619	1	0.9	0.125
2671_OG5_130593_5 - ANIMALS + FUNGI_YBL104C	YBL104C	"SEA4 - Subunit of the SEA (Seh1-associated) complex, a coatomer-related complex that associates dynamically with the vacuole; has an N-terminal beta-propeller fold and a C-terminal RING motif; promoter contains multiple GCN4 binding sites"	1	0	0	0	0.666666667	1	0.85	0.1875
2672_OG5_129422_5 - ANIMALS + FUNGI_YLR284C	YLR284C	"ECI1 - Peroxisomal delta3,delta2-enoyl-CoA isomerase, hexameric protein that converts 3-hexenoyl-CoA to trans-2-hexenoyl-CoA, essential for the beta-oxidation of unsaturated fatty acids, oleate-induced"	1	0	0.166666667	0.125	0.714285714	1	0.8	0.125
2673_OG5_129422_5 - ANIMALS + FUNGI_YOR180C	YOR180C	"DCI1 - Peroxisomal protein; identification as a delta(3,5)-delta(2,4)-dienoyl-CoA isomerase involved in fatty acid metabolism is disputed"	1	0	0.166666667	0.125	0.714285714	1	0.8	0.125
2674_OG5_129314_5 - ANIMALS + FUNGI_YBL105C	YBL105C	"PKC1 - Protein serine/threonine kinase essential for cell wall remodeling during growth; localized to sites of polarized growth and the mother-daughter bud neck; homolog of the alpha, beta, and gamma isoforms of mammalian protein kinase C (PKC)"	1	0	0	0	0.714285714	1	0.8	0.125
2675_OG5_129656_5 - ANIMALS + FUNGI_YJL100W	YJL100W	"LSB6 - Type II phosphatidylinositol 4-kinase that binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization"	1	0	0	0	0.714285714	1	0.8	0.125
2676_OG5_130680_5 - ANIMALS + FUNGI_YDR440W	YDR440W	"DOT1 - Nucleosomal histone H3-Lys79 methylase; methylation is required for telomeric silencing, meiotic checkpoint control, and DNA damage response"	1	0	0	0	0.714285714	1	0.8	0.125
2677_OG5_129821_5 - ANIMALS + FUNGI_YFR018C	YFR018C	YFR018C - Putative protein of unknown function	1	0	0.027777778	0	0.714285714	1	0.8	0.0625
2678_OG5_129202_5 - ANIMALS + FUNGI_YJL059W	YJL059W	YHC3 - Vacuolar membrane protein involved in the ATP-dependent transport of arginine into the vacuole and possibly in balancing ion homeostasis; homolog of human CLN3 involved in Batten disease (juvenile onset neuronal ceroid lipofuscinosis)	1	0	0	0	0.761904762	0.785714286	0.95	0.375
2679_OG5_129206_5 - ANIMALS + FUNGI_YLR281C	YLR281C	YLR281C - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR281C is not an essential gene	1	0	0.027777778	0	0.666666667	0.928571429	0.9	0.5625
2680_OG5_130391_5 - ANIMALS + FUNGI_YJR143C	YJR143C	"PMT4 - Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; appears to form homodimers in vivo and does not complex with other Pmt proteins; target for new antifungals"	1	0	0	0	0.476190476	1	1	0.0625
2681_OG5_130845_5 - ANIMALS + FUNGI_YKL033W	YKL033W	TTI1 - Putative protein of unknown function; subunit of the ASTRA complex which is part of the chromatin remodeling machinery; similar to S. pombe Tti1p; detected in highly purified mitochondria in high-throughput studies	1	0	0	0	0.619047619	0.857142857	1	0.0625
2682_OG5_128740_5 - ANIMALS + FUNGI_YPL242C	YPL242C	"IQG1 - Essential protein required for determination of budding pattern, promotes localization of axial markers Bud4p and Cdc12p and functionally interacts with Sec3p, localizes to the contractile ring during anaphase, member of the IQGAP family"	1	0.0625	0	0.125	0.523809524	1	0.95	0.1875
2683_OG5_129486_5 - ANIMALS + FUNGI_YIL131C	YIL131C	FKH1 - Forkhead family transcription factor with a minor role in the expression of G2/M phase genes; negatively regulates transcriptional elongation; positive role in chromatin silencing at HML and HMR; regulates donor preference during switching	1	0	0	0	0.571428571	1	0.9	0.0625
2684_OG5_129486_5 - ANIMALS + FUNGI_YNL068C	YNL068C	FKH2 - Forkhead family transcription factor with a major role in the expression of G2/M phase genes; positively regulates transcriptional elongation; negative role in chromatin silencing at HML and HMR; substrate of the Cdc28p/Clb5p kinase	1	0	0	0	0.571428571	1	0.9	0.0625
2685_OG5_129646_5 - ANIMALS + FUNGI_YOL057W	YOL057W	YOL057W - Dipeptidyl-peptidase III; cleaves dipeptides from the amino terminus of target proteins; highly active on synthetic substrate Arg-Arg-2-naphthylamide; mammalian ortholog may be a biomarker for some cancers	1	0	0	0.125	0.761904762	0.857142857	0.85	0.25
2686_OG5_127399_5 - ANIMALS + FUNGI_YBR041W	YBR041W	FAT1 - Very long chain fatty acyl-CoA synthetase and long chain fatty acid transporter; activates imported fatty acids with a preference for very long lengths (C20-C26); has a separate function in the transport of long chain fatty acids	1	0	0.055555556	0	0.666666667	1	0.8	0.25
2687_OG5_128147_5 - ANIMALS + FUNGI_YBR028C	YBR028C	YPK3 - An AGC kinase phosphorylated by cAMP-dependent protein kinase (PKA) in a TORC1-dependent manner	1	0	0	0.125	0.761904762	1	0.7	0.25
2688_OG5_129710_5 - ANIMALS + FUNGI_YJL005W	YJL005W	"CYR1 - Adenylate cyclase, required for cAMP production and cAMP-dependent protein kinase signaling; the cAMP pathway controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation"	1	0	0	0	0.523809524	0.928571429	1	0.0625
2689_OG5_129452_5 - ANIMALS + FUNGI_YML042W	YML042W	"CAT2 - Carnitine acetyl-CoA transferase present in both mitochondria and peroxisomes, transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes"	1	0	0	0	0.571428571	0.928571429	0.95	0.1875
2690_OG5_131192_5 - ANIMALS + FUNGI_YOR252W	YOR252W	TMA16 - Protein of unknown function that associates with ribosomes	1	0	0	0	0.523809524	1	0.9	0
2691_OG5_130016_5 - ANIMALS + FUNGI_YIL104C	YIL104C	"SHQ1 - Chaperone protein required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing, forms a complex with Naf1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; homology with known Hsp90p cochaperones"	1	0	0	0	0.857142857	1	0.55	0.3125
2692_OG5_130578_5 - ANIMALS + FUNGI_YPR163C	YPR163C	"TIF3 - Translation initiation factor eIF-4B, has RNA annealing activity; contains an RNA recognition motif and binds to single-stranded RNA"	1	0	0	0.125	0.619047619	0.785714286	1	0.125
2693_OG5_129940_5 - ANIMALS + FUNGI_YNL129W	YNL129W	"NRK1 - Nicotinamide riboside kinase, catalyzes the phosphorylation of nicotinamide riboside and nicotinic acid riboside in salvage pathways for NAD+ biosynthesis"	1	0	0	0	0.476190476	0.928571429	1	0
2694_OG5_131004_5 - ANIMALS + FUNGI_YDR392W	YDR392W	"SPT3 - Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters"	1	0	0	0	0.476190476	0.928571429	1	0.0625
2695_OG5_130455_5 - ANIMALS + FUNGI_YBR235W	YBR235W	"YBR235W - Putative ion transporter, similar to mammalian electroneutral Na(+)-(K+)-C1- cotransporter family; YBR235W is not an essential gene"	1	0	0	0	0.666666667	0.928571429	0.8	0.0625
2696_OG5_129923_5 - ANIMALS + FUNGI_YGL191W	YGL191W	"COX13 - Subunit VIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; not essential for cytochrome c oxidase activity but may modulate activity in response to ATP"	1	0	0	0	0.619047619	0.857142857	0.9	0
2697_OG5_128792_5 - ANIMALS + FUNGI_YMR162C	YMR162C	DNF3 - Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secretory vesicles; localizes to the trans-Golgi network; likely involved in protein transport; type 4 P-type ATPase	1	0	0	0	0.619047619	1	0.75	0.125
2698_OG5_130914_5 - ANIMALS + FUNGI_YNL097C	YNL097C	"PHO23 - Probable component of the Rpd3 histone deacetylase complex, involved in transcriptional regulation of PHO5; C-terminus has similarity to human candidate tumor suppressor p33(ING1) and its isoform ING3"	1	0	0	0	0.619047619	1	0.75	0
2699_OG5_130567_5 - ANIMALS + FUNGI_YOR098C	YOR098C	"NUP1 - Nuclear pore complex (NPC) subunit, involved in protein import/export and in export of RNAs, possible karyopherin release factor that accelerates release of karyopherin-cargo complexes after transport across NPC; potential Cdc28p substrate"	1	0	0	0.125	0.714285714	1	0.65	0.1875
2700_OG5_131169_5 - ANIMALS + FUNGI_YOL045W	YOL045W	"PSK2 - One of two (see also PSK1) PAS domain containing S/T protein kinases; regulates sugar flux and translation in response to an unknown metabolite by phosphorylating Ugp1p and Gsy2p (sugar flux) and Caf20p, Tif11p and Sro9p (translation)"	1	0	0	0	0.428571429	0.928571429	1	0
2701_OG5_131169_5 - ANIMALS + FUNGI_YAL017W	YAL017W	PSK1 - One of two (see also PSK2) PAS domain containing S/T protein kinases; coordinately regulates protein synthesis and carbohydrate metabolism and storage in response to a unknown metabolite that reflects nutritional status	1	0	0	0	0.428571429	0.928571429	1	0
2702_OG5_131463_5 - ANIMALS + FUNGI_YDR527W	YDR527W	"RBA50 - Protein involved in transcription; interacts with RNA polymerase II subunits Rpb2p, Rpb3, and Rpb11p; has similarity to human RPAP1"	1	0	0	0	0.428571429	0.928571429	1	0
2703_OG5_131561_5 - ANIMALS + FUNGI_YMR004W	YMR004W	MVP1 - Protein required for sorting proteins to the vacuole; overproduction of Mvp1p suppresses several dominant VPS1 mutations; Mvp1p and Vps1p act in concert to promote membrane traffic to the vacuole	1	0	0	0	0.380952381	1	0.95	0
2704_OG5_131141_5 - ANIMALS + FUNGI_YPL084W	YPL084W	BRO1 - Cytoplasmic class E vacuolar protein sorting (VPS) factor that coordinates deubiquitination in the multivesicular body (MVB) pathway by recruiting Doa4p to endosomes	1	0	0	0	0.619047619	0.857142857	0.85	0.0625
2705_OG5_129469_5 - ANIMALS + FUNGI_YLR231C	YLR231C	"BNA5 - Kynureninase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p"	1	0.125	0.138888889	0	0.476190476	1	0.85	0.25
2706_OG5_128593_5 - ANIMALS + FUNGI_YNL125C	YNL125C	"ESBP6 - Protein with similarity to monocarboxylate permeases, appears not to be involved in transport of monocarboxylates such as lactate, pyruvate or acetate across the plasma membrane"	1	0.0625	0	0	0.523809524	1	0.8	0
2707_OG5_128593_5 - ANIMALS + FUNGI_YKL221W	YKL221W	"MCH2 - Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport"	1	0.0625	0	0	0.523809524	1	0.8	0
2708_OG5_129555_5 - ANIMALS + FUNGI_YER051W	YER051W	"JHD1 - JmjC domain family histone demethylase specific for H3-K36, similar to proteins found in human, mouse, drosophila, X. laevis, C. elegans, and S. pombe"	1	0	0	0.125	0.761904762	1	0.55	0
2709_OG5_131318_5 - ANIMALS + FUNGI_YOR278W	YOR278W	"HEM4 - Uroporphyrinogen III synthase, catalyzes the conversion of hydroxymethylbilane to uroporphyrinogen III, the fourth step in heme biosynthesis; deficiency in the human homolog can result in the disease congenital erythropoietic porphyria"	1	0	0	0	0.428571429	0.857142857	1	0.125
2710_OG5_131578_5 - ANIMALS + FUNGI_YGL020C	YGL020C	GET1 - Subunit of the GET complex; involved in insertion of proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for normal mitochondrial morphology and inheritance	1	0	0	0	0.428571429	0.857142857	1	0
2711_OG5_131334_5 - ANIMALS + FUNGI_YKL003C	YKL003C	"MRP17 - Mitochondrial ribosomal protein of the small subunit; MRP17 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator"	1	0	0	0	0.761904762	0.571428571	0.95	0.0625
2712_OG5_131083_5 - ANIMALS + FUNGI_YDR198C	YDR198C	"RKM2 - Ribosomal protein lysine methyltransferase, responsible for trimethylation of the lysine residue at position 3 of Rpl12Ap and Rpl12Bp"	1	0	0	0.125	0.476190476	1	0.8	0
2713_OG5_130893_5 - ANIMALS + FUNGI_YOL147C	YOL147C	"PEX11 - Peroxisomal membrane protein required for medium-chain fatty acid oxidation and peroxisome proliferation, possibly by inducing membrane curvature; localization regulated by phosphorylation; transcription regulated by Adr1p and Pip2p-Oaf1p"	1	0	0	0	0.476190476	0.785714286	1	0.125
2714_OG5_130806_5 - ANIMALS + FUNGI_YML032C	YML032C	RAD52 - Protein that stimulates strand exchange by facilitating Rad51p binding to single-stranded DNA; anneals complementary single-stranded DNA; involved in the repair of double-strand breaks in DNA during vegetative growth and meiosis	1	0	0	0	0.380952381	0.928571429	0.95	0.1875
2715_OG5_131574_5 - ANIMALS + FUNGI_YCL057C-A	YCL057C-A	"YCL057C-A - Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"	1	0	0	0	0.523809524	0.857142857	0.85	0
2716_OG5_131009_5 - ANIMALS + FUNGI_YGR217W	YGR217W	"CCH1 - Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together"	1	0	0	0	0.666666667	0.857142857	0.7	0.0625
2717_OG5_129446_5 - ANIMALS + FUNGI_YAR018C	YAR018C	KIN3 - Nonessential serine/threonine protein kinase; possible role in DNA damage response	1	0	0	0	0.285714286	0.928571429	1	0.625
2718_OG5_127859_5 - ANIMALS + FUNGI_YLR372W	YLR372W	"SUR4 - Elongase, involved in fatty acid and sphingolipid biosynthesis; synthesizes very long chain 20-26-carbon fatty acids from C18-CoA primers; involved in regulation of sphingolipid biosynthesis"	1	0	0	0.125	0.761904762	1	0.45	0.5
2719_OG5_127859_5 - ANIMALS + FUNGI_YJL196C	YJL196C	"ELO1 - Elongase I, medium-chain acyl elongase, catalyzes carboxy-terminal elongation of unsaturated C12-C16 fatty acyl-CoAs to C16-C18 fatty acids"	1	0	0	0.125	0.761904762	1	0.45	0.5
2720_OG5_131602_5 - ANIMALS + FUNGI_YOL138C	YOL138C	"RTC1 - Subunit of the SEA (Seh1-associated) complex, a coatomer-related complex that associates dynamically with the vacuole; null mutation suppresses cdc13-1 temperature sensitivity; has N-terminal WD-40 repeats and a C-terminal RING motif"	1	0	0	0	0.761904762	0.928571429	0.5	0.0625
2721_OG5_131840_5 - ANIMALS + FUNGI_YJL036W	YJL036W	"SNX4 - Sorting nexin, involved in retrieval of late-Golgi SNAREs from post-Golgi endosomes to the trans-Golgi network and in cytoplasm to vacuole transport; contains a PX phosphoinositide-binding domain; forms complexes with Snx41p and with Atg20p"	1	0	0	0	0.238095238	0.928571429	1	0
2722_OG5_130682_5 - ANIMALS + FUNGI_YDR057W	YDR057W	"YOS9 - ER quality-control lectin; integral subunit of the HRD ligase; binds to glycans with terminal alpha-1,6 linked mannose on misfolded N-glycosylated proteins and participates in targeting proteins to ERAD; member of the OS-9 protein family"	1	0	0	0.125	0.80952381	1	0.35	0.1875
2723_OG5_131851_5 - ANIMALS + FUNGI_YBR278W	YBR278W	"DPB3 - Third-largest subunit of DNA polymerase II (DNA polymerase epsilon), required to maintain fidelity of chromosomal replication and also for inheritance of telomeric silencing; mRNA abundance peaks at the G1/S boundary of the cell cycle"	1	0	0	0.125	0.666666667	0.928571429	0.55	0.0625
2724_OG5_131682_5 - ANIMALS + FUNGI_YAL020C	YAL020C	"ATS1 - Protein required, with Elongator complex, Kti11p, and Kti12p, for modification of wobble nucleosides in tRNA; has a potential role in regulatory interactions between microtubules and the cell cycle"	1	0	0	0	0.476190476	0.714285714	0.95	0.0625
2725_OG5_130864_5 - ANIMALS + FUNGI_YNL155W	YNL155W	"YNL155W - Putative protein of unknown function; contains a DHHC domain and an AN1-type zinc finger; predicted to have thiol-disulfide oxidoreductase active site; transcriptionally regulated by Rpn4p along with proteasome subunit genes; putative ortholog of human AIRAP, which stimulates proteasome activity in response to arsenic"	1	0	0	0	0.476190476	0.857142857	0.8	0.25
2726_OG5_131122_5 - ANIMALS + FUNGI_YOL081W	YOL081W	"IRA2 - GTPase-activating protein that negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, has similarity to Ira1p and human neurofibromin"	1	0	0	0	0.476190476	1	0.65	0.0625
2727_OG5_131122_5 - ANIMALS + FUNGI_YBR140C	YBR140C	"IRA1 - GTPase-activating protein that negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, mediates membrane association of adenylate cyclase"	1	0	0	0	0.476190476	1	0.65	0.0625
2728_OG5_131768_5 - ANIMALS + FUNGI_YJR025C	YJR025C	"BNA1 - 3-hydroxyanthranilic acid dioxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p"	1	0	0	0	0.333333333	0.928571429	0.85	0
2729_OG5_131476_5 - ANIMALS + FUNGI_YNL239W	YNL239W	LAP3 - Cysteine aminopeptidase with homocysteine-thiolactonase activity; protects cells against homocysteine toxicity; has bleomycin hydrolase activity in vitro; transcription is regulated by galactose via Gal4p; orthologous to human BLMH	1	0	0.083333333	0	0.571428571	0.928571429	0.6	0
2730_OG5_131714_5 - ANIMALS + FUNGI_YGR057C	YGR057C	LST7 - Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface	1	0	0	0	0.619047619	1	0.45	0.0625
2731_OG5_131276_5 - ANIMALS + FUNGI_YJR073C	YJR073C	"OPI3 - Phospholipid methyltransferase (methylene-fatty-acyl-phospholipid synthase), catalyzes the last two steps in phosphatidylcholine biosynthesis"	1	0	0	0	0.238095238	0.857142857	0.95	0.0625
2732_OG5_130881_5 - ANIMALS + FUNGI_YIR029W	YIR029W	"DAL2 - Allantoicase, converts allantoate to urea and ureidoglycolate in the second step of allantoin degradation; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation"	1	0	0.083333333	0	0.333333333	0.857142857	0.85	0.125
2733_OG5_131859_5 - ANIMALS + FUNGI_YCR016W	YCR016W	YCR016W - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus and nucleus; predicted to be involved in ribosome biogenesis	1	0	0	0.125	0.571428571	0.642857143	0.8	0.125
2734_OG5_130189_5 - ANIMALS + FUNGI_YNL040W	YNL040W	YNL040W - Putative protein of unknown function with strong similarity to alanyl-tRNA synthases from Eubacteria; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL040W is not an essential gene	1	0.0625	0.111111111	0.125	0.380952381	1	0.6	0.3125
2735_OG5_131051_5 - ANIMALS + FUNGI_YMR202W	YMR202W	"ERG2 - C-8 sterol isomerase, catalyzes the isomerization of the delta-8 double bond to the delta-7 position at an intermediate step in ergosterol biosynthesis"	1	0	0	0	0.285714286	0.785714286	0.9	0.125
2736_OG5_132901_5 - ANIMALS + FUNGI_YNL038W	YNL038W	"GPI15 - Protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; homologous to the human PIG-H protein"	1	0	0	0	0.380952381	0.928571429	0.6	0
2737_OG5_129495_5 - ANIMALS + FUNGI_YPR026W	YPR026W	ATH1 - Acid trehalase required for utilization of extracellular trehalose	1	0	0.194444444	0	0.380952381	0.857142857	0.65	0.1875
2738_OG5_131166_5 - ANIMALS + FUNGI_YIR015W	YIR015W	"RPR2 - Subunit of nuclear RNase P; nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; not shared between RNase MRP and RNase P, in contrast to all other RNase P protein subunits"	1	0	0	0	0.380952381	0.642857143	0.8	0.125
2739_OG5_129680_5 - ANIMALS + FUNGI_YIL159W	YIL159W	"BNR1 - Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNI1"	1	0	0	0	0.619047619	1	0.2	0.0625
2740_OG5_130784_5 - ANIMALS + FUNGI_YAL007C	YAL007C	"ERP2 - Protein that forms a heterotrimeric complex with Erp1p, Emp24p, and Erv25p; member, along with Emp24p and Erv25p, of the p24 family involved in ER to Golgi transport and localized to COPII-coated vesicles"	1	0	0	0	0.714285714	1	0.1	0.0625
2741_OG5_130306_5 - ANIMALS + FUNGI_YDL230W	YDL230W	"PTP1 - Phosphotyrosine-specific protein phosphatase that dephosphorylates a broad range of substrates in vivo, including Fpr3p; localized to the cytoplasm and the mitochondria; proposed to be a negative regulator of filamentation"	1	0	0	0	0.523809524	1	0.25	0.125
2742_OG5_132832_5 - ANIMALS + FUNGI_YDR066C	YDR066C	RTR2 - Protein of unknown function with high similarity to Rtr1p; exhibits genetic interactions with Rtr1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YDR066C is not an essential gene	1	0	0	0	0.714285714	0.928571429	0.1	0.0625
2743_OG5_132669_5 - ANIMALS + FUNGI_YJL003W	YJL003W	"COX16 - Mitochondrial inner membrane protein, required for assembly of cytochrome c oxidase"	1	0	0	0	0.285714286	0.5	0.95	0
2744_OG5_132700_5 - ANIMALS + FUNGI_YOR022C	YOR022C	"YOR022C - Protein with similarity to bovine phospholipase A1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"	1	0	0	0	0.333333333	1	0.4	0.125
2745_OG5_133715_5 - ANIMALS + FUNGI_YOR016C	YOR016C	"ERP4 - Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport"	1	0	0	0	0.523809524	1	0.2	0
2746_OG5_132659_5 - ANIMALS + FUNGI_YIL113W	YIL113W	"SDP1 - Stress-inducible dual-specificity MAP kinase phosphatase, negatively regulates Slt2p MAP kinase by direct dephosphorylation, diffuse localization under normal conditions shifts to punctate localization after heat shock"	1	0	0	0	0.619047619	1	0.1	0.0625
2747_OG5_131308_5 - ANIMALS + FUNGI_YDL204W	YDL204W	RTN2 - Protein of unknown function; has similarity to mammalian reticulon proteins; member of the RTNLA (reticulon-like A) subfamily	1	0	0	0.125	0.666666667	1	0.05	0.25
2748_OG5_129717_5 - ANIMALS + FUNGI_YDR524C	YDR524C	"AGE1 - ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in the secretory and endocytic pathways; contains C2C2H2 cysteine/histidine motif"	1	0	0	0.125	0.571428571	1	0.1	0.0625
2749_OG5_129052_5 - ANIMALS + FUNGI_YDR081C	YDR081C	"PDC2 - Transcription factor required for the synthesis of the glycolytic enzyme pyruvate decarboxylase, required for high level expression of both the THI and the PDC genes"	1	0	0	0.125	0.333333333	0.571428571	0.7	0.0625
2750_OG5_134185_5 - ANIMALS + FUNGI_YGL254W	YGL254W	"FZF1 - Transcription factor involved in sulfite metabolism, sole identified regulatory target is SSU1, overexpression suppresses sulfite-sensitivity of many unrelated mutants due to hyperactivation of SSU1, contains five zinc fingers"	1	0	0	0	0.428571429	0.928571429	0.2	0
2751_OG5_134174_5 - ANIMALS + FUNGI_YER045C	YER045C	"ACA1 - Basic leucine zipper (bZIP) transcription factor of the ATF/CREB family, may regulate transcription of genes involved in utilization of non-optimal carbon sources"	1	0	0	0	0.380952381	1	0.1	0
2752_OG5_134293_5 - ANIMALS + FUNGI_YGL004C	YGL004C	RPN14 - Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasome regulatory particle (RP); null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; interacts with Rpt5p	1	0	0	0	0.476190476	0.642857143	0.35	0.125
2753_OG5_135254_5 - ANIMALS + FUNGI_YBR182C	YBR182C	SMP1 - Putative transcription factor involved in regulating the response to osmotic stress; member of the MADS-box family of transcription factors	1	0	0	0	0.238095238	1	0.1	0
2754_OG5_133338_5 - ANIMALS + FUNGI_YGL196W	YGL196W	DSD1 - D-serine dehydratase (aka D-serine ammonia-lyase); converts D-serine to pyruvate and ammonia by a reaction dependent on pyridoxal 5'-phosphate and zinc; may play a role in D-serine detoxification; L-serine is not a substrate	1	0	0.055555556	0	0.238095238	0.214285714	0.85	0.0625
2755_OG5_135264_5 - ANIMALS + FUNGI_YOR113W	YOR113W	"AZF1 - Zinc-finger transcription factor, involved in induction of CLN3 transcription in response to glucose; genetic and physical interactions indicate a possible role in mitochondrial transcription or genome maintenance"	1	0	0	0	0.238095238	0.214285714	0.65	0
2756_OG5_144393_5 - ANIMALS + FUNGI_YDR451C	YDR451C	"YHP1 - One of two homeobox transcriptional repressors (see also Yox1p), that bind to Mcm1p and to early cell cycle box (ECB) elements of cell cycle regulated genes, thereby restricting ECB-mediated transcription to the M/G1 interval"	1	0	0	0	0.095238095	0.642857143	0.05	0
2757_OG5_129356_6 - PLANTS + FUNGI_YOL064C	YOL064C	"MET22 - Bisphosphate-3'-nucleotidase, involved in salt tolerance and methionine biogenesis; dephosphorylates 3'-phosphoadenosine-5'-phosphate and 3'-phosphoadenosine-5'-phosphosulfate, intermediates of the sulfate assimilation pathway"	1	0.0625	0.305555556	1	0.238095238	0	1	0.25
2758_OG5_129172_6 - PLANTS + FUNGI_YML008C	YML008C	"ERG6 - Delta(24)-sterol C-methyltransferase, converts zymosterol to fecosterol in the ergosterol biosynthetic pathway by methylating position C-24; localized to both lipid particles and mitochondrial outer membrane"	1	0.1875	0.055555556	1	0.333333333	0	1	0.1875
2759_OG5_130960_6 - PLANTS + FUNGI_YJR137C	YJR137C	"MET5 - Sulfite reductase beta subunit, involved in amino acid biosynthesis, transcription repressed by methionine"	1	0.125	0.222222222	1	0.19047619	0	1	0.0625
2760_OG5_129047_6 - PLANTS + FUNGI_YLR220W	YLR220W	"CCC1 - Putative vacuolar Fe2+/Mn2+ transporter; suppresses respiratory deficit of yfh1 mutants, which lack the ortholog of mammalian frataxin, by preventing mitochondrial iron accumulation"	1	0.1875	0.027777778	1	0.238095238	0	1	0.625
2761_OG5_130282_6 - PLANTS + FUNGI_YBR021W	YBR021W	"FUR4 - Uracil permease, localized to the plasma membrane; expression is tightly regulated by uracil levels and environmental cues"	1	0.125	0.166666667	1	0.047619048	0	1	0
2762_OG5_130282_6 - PLANTS + FUNGI_YBL042C	YBL042C	"FUI1 - High affinity uridine permease, localizes to the plasma membrane; also mediates low but significant transport of the cytotoxic nucleoside analog 5-fluorouridine; not involved in uracil transport"	1	0.125	0.166666667	1	0.047619048	0	1	0
2763_OG5_130282_6 - PLANTS + FUNGI_YIR028W	YIR028W	"DAL4 - Allantoin permease; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation"	1	0.125	0.166666667	1	0.047619048	0	1	0
2764_OG5_129514_6 - PLANTS + FUNGI_YCR091W	YCR091W	KIN82 - Putative serine/threonine protein kinase implicated in the regulation of phospholipid asymmetry through the activation of phospholipid translocases (flippases) Lem3p-Dnf1p/Dnf2p; similar to Fpk1p	1	0.0625	0.027777778	1	0.19047619	0	1	0.1875
2765_OG5_129514_6 - PLANTS + FUNGI_YNR047W	YNR047W	"FPK1 - Ser/Thr protein kinase that regulates the putative phospholipid translocases Lem3p-Dnf1p/Dnf2p; phosphorylates and inhibits upstream inhibitory kinase, Ypk1p; localizes to the cytoplasm, early endosome/TGN compartments, and plasma membrane"	1	0.0625	0.027777778	1	0.19047619	0	1	0.1875
2766_OG5_132706_6 - PLANTS + FUNGI_YGL078C	YGL078C	DBP3 - Putative ATP-dependent RNA helicase of the DEAD-box family involved in ribosomal biogenesis	1	0.0625	0.027777778	1	0.095238095	0	1	0.0625
2767_OG5_128727_6 - PLANTS + FUNGI_YNL231C	YNL231C	"PDR16 - Phosphatidylinositol transfer protein (PITP) controlled by the multiple drug resistance regulator Pdr1p, localizes to lipid particles and microsomes, controls levels of various lipids, may regulate lipid synthesis, homologous to Pdr17p"	1	0	0	1	0.238095238	0	1	0.5625
2768_OG5_128727_6 - PLANTS + FUNGI_YNL264C	YNL264C	"PDR17 - Phosphatidylinositol transfer protein (PITP), downregulates Plb1p-mediated turnover of phosphatidylcholine, found in the cytosol and microsomes, homologous to Pdr16p, deletion affects phospholipid composition"	1	0	0	1	0.238095238	0	1	0.5625
2769_OG5_131525_6 - PLANTS + FUNGI_YGR149W	YGR149W	YGR149W - Putative protein of unknown function; predicted to be an integal membrane protein	1	0	0	1	0.238095238	0	1	0.0625
2770_OG5_128997_6 - PLANTS + FUNGI_YOR165W	YOR165W	"SEY1 - GTPase with a role in ER morphology; interacts physically and genetically with Yop1p and Rtn1p; possible functional ortholog of mammalian atlastins, defects in which cause a form of hereditary spastic paraplegia; homolog of Arabidopsis RHD3"	1	0	0	1	0.19047619	0	1	0.6875
2771_OG5_129432_6 - PLANTS + FUNGI_YDR074W	YDR074W	"TPS2 - Phosphatase subunit of the trehalose-6-phosphate synthase/phosphatase complex, which synthesizes the storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway"	1	0	0	1	0.19047619	0	1	0.4375
2772_OG5_132042_6 - PLANTS + FUNGI_YPR060C	YPR060C	"ARO7 - Chorismate mutase, catalyzes the conversion of chorismate to prephenate to initiate the tyrosine/phenylalanine-specific branch of aromatic amino acid biosynthesis"	1	0	0	1	0.142857143	0	1	0.0625
2773_OG5_132917_6 - PLANTS + FUNGI_YIL020C	YIL020C	"HIS6 - Phosphoribosyl-5-amino-1-phosphoribosyl-4-imidazolecarboxiamide isomerase, catalyzes the fourth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts"	1	0	0	1	0.142857143	0	1	0.0625
2774_OG5_129822_6 - PLANTS + FUNGI_YIL070C	YIL070C	MAM33 - Acidic protein of the mitochondrial matrix involved in oxidative phosphorylation; related to the human complement receptor gC1q-R	1	0	0	1	0.095238095	0	1	0.5
2775_OG5_130376_6 - PLANTS + FUNGI_YLR290C	YLR290C	"YLR290C - Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YLR290C is not an essential gene"	1	0	0	1	0.095238095	0	1	0.25
2776_OG5_131155_6 - PLANTS + FUNGI_YNR008W	YNR008W	LRO1 - Acyltransferase that catalyzes diacylglycerol esterification; one of several acyltransferases that contribute to triglyceride synthesis; putative homolog of human lecithin cholesterol acyltransferase	1	0	0	1	0.095238095	0	1	0.25
2777_OG5_127693_6 - PLANTS + FUNGI_YLR342W	YLR342W	"FKS1 - Catalytic subunit of 1,3-beta-D-glucan synthase, functionally redundant with alternate catalytic subunit Gsc2p; binds to regulatory subunit Rho1p; involved in cell wall synthesis and maintenance; localizes to sites of cell wall remodeling"	1	0	0	1	0.047619048	0	1	0.1875
2778_OG5_127693_6 - PLANTS + FUNGI_YGR032W	YGR032W	"GSC2 - Catalytic subunit of 1,3-beta-glucan synthase, involved in formation of the inner layer of the spore wall; activity positively regulated by Rho1p and negatively by Smk1p; has similarity to an alternate catalytic subunit, Fks1p (Gsc1p)"	1	0	0	1	0.047619048	0	1	0.1875
2779_OG5_127693_6 - PLANTS + FUNGI_YMR306W	YMR306W	"FKS3 - Protein involved in spore wall assembly, has similarity to 1,3-beta-D-glucan synthase catalytic subunits Fks1p and Gsc2p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"	1	0	0	1	0.047619048	0	1	0.1875
2780_OG5_133336_6 - PLANTS + FUNGI_YDR465C	YDR465C	RMT2 - Arginine N5 methyltransferase; methylates ribosomal protein Rpl12 (L12) on Arg67	1	0	0	1	0.047619048	0	1	0.0625
2781_OG5_129761_6 - PLANTS + FUNGI_YFL028C	YFL028C	CAF16 - Part of evolutionarily-conserved CCR4-NOT regulatory complex; contains single ABC-type ATPase domain but no transmembrane domain; interacts with several subunits of Mediator	1	0.1875	0	1	0.095238095	0	1	0.4375
2782_OG5_130129_6 - PLANTS + FUNGI_YLR420W	YLR420W	"URA4 - Dihydroorotase, catalyzes the third enzymatic step in the de novo biosynthesis of pyrimidines, converting carbamoyl-L-aspartate into dihydroorotate"	1	0	0.388888889	1	0.142857143	0	1	0.375
2783_OG5_129101_6 - PLANTS + FUNGI_YKR089C	YKR089C	"TGL4 - Multifunctional triacylglycerol lipase, steryl ester hydrolase, and Ca2+-independent phospholipase A2; catalyzes acyl-CoA dependent acylation of LPA to PA; required with Tgl3p for timely bud formation; phosphorylated and activated by Cdc28p"	1	0	0.027777778	1	0.19047619	0	1	0.4375
2784_OG5_129101_6 - PLANTS + FUNGI_YOR081C	YOR081C	TGL5 - Bifunctional enzyme with triacylglycerol lipase and lysophosphatidic acid acyltransferase activity; involved in triacylglycerol mobilization; localizes to lipid particles; potential Cdc28p substrate	1	0	0.027777778	1	0.19047619	0	1	0.4375
2785_OG5_132306_6 - PLANTS + FUNGI_YGR205W	YGR205W	TDA10 - ATP-binding protein of unknown function; crystal structure resembles that of E.coli pantothenate kinase and other small kinases; null mutant is sensitive to expression of the top1-T722A allele	1	0	0.027777778	1	0.095238095	0	1	0.1875
2786_OG5_129563_6 - PLANTS + FUNGI_YGL014W	YGL014W	"PUF4 - Member of the PUF protein family, which is defined by the presence of Pumilio homology domains that confer RNA binding activity; preferentially binds mRNAs encoding nucleolar ribosomal RNA-processing factors"	1	0	0	1	0.238095238	0	0.95	0.625
2787_OG5_132596_6 - PLANTS + FUNGI_YMR283C	YMR283C	"RIT1 - 2'-O-ribosyl phosphate transferase, modifies the initiator methionine tRNA at position 64 to distinguish it from elongator methionine tRNA"	1	0	0	1	0.19047619	0	0.95	0.0625
2788_OG5_132918_6 - PLANTS + FUNGI_YGR012W	YGR012W	"YGR012W - Putative cysteine synthase, localized to the mitochondrial outer membrane"	1	0	0	1	0.19047619	0	0.95	0.0625
2789_OG5_132559_6 - PLANTS + FUNGI_YDR414C	YDR414C	"ERD1 - Predicted membrane protein required for the retention of lumenal endoplasmic reticulum proteins; mutants secrete the endogenous ER protein, BiP (Kar2p)"	1	0	0	1	0.142857143	0	0.95	0.0625
2790_OG5_130177_6 - PLANTS + FUNGI_YDR194C	YDR194C	MSS116 - DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing	1	0	0	1	0.047619048	0	0.95	0.25
2791_OG5_132717_6 - PLANTS + FUNGI_YHR009C	YHR009C	"TDA3 - Putative oxidoreductase involved in late endosome to Golgi transport; physical and genetical interactions with Btn2p; null mutant is viable, has extended S phase, and sensitive to expression of top1-T722A allele; similar to human FOXRED1"	1	0	0	1	0.047619048	0	0.95	0.0625
2792_OG5_133734_6 - PLANTS + FUNGI_YNL011C	YNL011C	YNL011C - Putative protein of unknown function; YNL011C is not an essential gene	1	0	0	1	0.095238095	0	0.9	0
2793_OG5_129798_6 - PLANTS + FUNGI_YPL239W	YPL239W	"YAR1 - Cytoplasmic ankyrin-repeat containing protein of unknown function, proposed to link the processes of 40S ribosomal subunit biogenesis and adaptation to osmotic and oxidative stress; expression repressed by heat shock"	1	0	0	0.875	0.333333333	0.071428571	1	0.6875
2794_OG5_129847_6 - PLANTS + FUNGI_YKL034W	YKL034W	"TUL1 - Golgi-localized RING-finger ubiquitin ligase (E3), involved in ubiquitinating and sorting membrane proteins that contain polar transmembrane domains to multivesicular bodies for delivery to the vacuole for quality control purposes"	1	0	0	0.875	0.333333333	0	1	0.5
2795_OG5_131364_6 - PLANTS + FUNGI_YHR039C	YHR039C	"MSC7 - Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; msc7 mutants are defective in directing meiotic recombination events to homologous chromatids"	1	0	0	0.875	0.19047619	0	1	0.1875
2796_OG5_132586_6 - PLANTS + FUNGI_YGR271C-A	YGR271C-A	EFG1 - Essential protein required for maturation of 18S rRNA; null mutant is sensitive to hydroxyurea and is delayed in recovering from alpha-factor arrest; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus	1	0	0	0.875	0.19047619	0	1	0.1875
2797_OG5_130473_6 - PLANTS + FUNGI_YNL212W	YNL212W	"VID27 - Cytoplasmic protein of unknown function; possibly involved in vacuolar protein degradation; not essential for proteasome-dependent degradation of fructose-1,6-bisphosphatase (FBPase); null mutants exhibit normal growth"	1	0	0	0.875	0.095238095	0	1	0.5625
2798_OG5_132851_6 - PLANTS + FUNGI_YGR119C	YGR119C	"NUP57 - Nucleoporin, essential subunit of the nuclear pore complex (NPC), functions as the organizing center of an NPC subcomplex containing Nsp1p, Nup49p, Nup57p, and Nic96p"	1	0	0	0.875	0.095238095	0	1	0
2799_OG5_130623_6 - PLANTS + FUNGI_YFR007W	YFR007W	YFH7 - Putative kinase with similarity to the phosphoribulokinase/uridine kinase/bacterial pantothenate kinase (PRK/URK/PANK) subfamily of P-loop kinases	1	0	0.138888889	0.875	0.142857143	0	1	0.1875
2800_OG5_132457_6 - PLANTS + FUNGI_YOR238W	YOR238W	YOR238W - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	1	0	0	1	0.095238095	0	0.85	0.125
2801_OG5_133341_6 - PLANTS + FUNGI_YHR100C	YHR100C	"GEP4 - Mitochondrial phosphatidylglycerophosphatase (PGP phosphatase), dephosphorylates phosphatidylglycerolphosphate to generate phosphatidylglycerol, an essential step during cardiolipin biosynthesis; null mutant is sensitive to tunicamycin, DTT"	1	0	0	0.875	0.19047619	0	0.95	0.0625
2802_OG5_133044_6 - PLANTS + FUNGI_YJR095W	YJR095W	"SFC1 - Mitochondrial succinate-fumarate transporter, transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization"	1	0	0	0.875	0.142857143	0	0.95	0.0625
2803_OG5_131275_6 - PLANTS + FUNGI_YMR262W	YMR262W	YMR262W - Protein of unknown function; interacts weakly with Knr4p; YMR262W is not an essential gene	1	0	0.027777778	0.875	0.19047619	0	0.95	0.25
2804_OG5_131532_6 - PLANTS + FUNGI_YGL010W	YGL010W	YGL010W - Putative protein of unknown function; YGL010W is not an essential gene	1	0	0.111111111	0.875	0.142857143	0	0.95	0.1875
2805_OG5_133347_6 - PLANTS + FUNGI_YPL246C	YPL246C	"RBD2 - Possible rhomboid protease, has similarity to eukaryotic rhomboid proteases including Pcp1p"	1	0.0625	0	1	0.095238095	0	0.8	0.0625
2806_OG5_132652_6 - PLANTS + FUNGI_YPR128C	YPR128C	ANT1 - Peroxisomal adenine nucleotide transporter; involved in beta-oxidation of medium-chain fatty acid; required for peroxisome proliferation	1	0	0	0.875	0.047619048	0	0.9	0.1875
2807_OG5_130511_6 - PLANTS + FUNGI_YGR276C	YGR276C	RNH70 - 3'-5' exoribonuclease; required for maturation of 3' ends of 5S rRNA and tRNA-Arg3 from dicistronic transcripts	1	0	0	0.75	0.238095238	0	1	0.3125
2808_OG5_131167_6 - PLANTS + FUNGI_YMR015C	YMR015C	"ERG5 - C-22 sterol desaturase, a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs"	1	0	0	0.75	0.19047619	0	1	0.125
2809_OG5_131278_6 - PLANTS + FUNGI_YDL046W	YDL046W	"NPC2 - Functional homolog of human NPC2/He1, which is a cholesterol-binding protein whose deficiency causes Niemann-Pick type C2 disease involving retention of cholesterol in lysosomes"	1	0	0	0.75	0.095238095	0	1	0.0625
2810_OG5_131845_6 - PLANTS + FUNGI_YOR191W	YOR191W	ULS1 - RING finger protein involved in proteolytic control of sumoylated substrates; interacts with SUMO (Smt3p); member of the SWI/SNF family of DNA-dependent ATPases; plays a role in antagonizing silencing during mating-type switching	1	0	0	0.75	0.047619048	0	1	0
2811_OG5_133261_6 - PLANTS + FUNGI_YDR297W	YDR297W	"SUR2 - Sphinganine C4-hydroxylase, catalyses the conversion of sphinganine to phytosphingosine in sphingolipid biosyntheis"	1	0	0	0.75	0	0	1	0
2812_OG5_126789_6 - PLANTS + FUNGI_YHR179W	YHR179W	"OYE2 - Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN), homologous to Oye3p with different ligand binding and catalytic properties; may be involved in sterol metabolism, oxidative stress response, and programmed cell death"	1	0	0.444444444	0.75	0.19047619	0	1	0.25
2813_OG5_126789_6 - PLANTS + FUNGI_YPL171C	YPL171C	"OYE3 - Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN), homologous to Oye2p with different ligand binding and catalytic properties; has potential roles in oxidative stress response and programmed cell death"	1	0	0.444444444	0.75	0.19047619	0	1	0.25
2814_OG5_131725_6 - PLANTS + FUNGI_YGR170W	YGR170W	"PSD2 - Phosphatidylserine decarboxylase of the Golgi and vacuolar membranes, converts phosphatidylserine to phosphatidylethanolamine"	1	0	0.333333333	0.75	0.095238095	0	1	0
2815_OG5_129045_6 - PLANTS + FUNGI_YOR197W	YOR197W	MCA1 - Putative cysteine protease similar to mammalian caspases; involved in regulation of apoptosis upon H2O2 treatment; contributes to clearance of insoluble protein aggregates during normal growth; may be involved in cell cycle progression	1	0	0.027777778	0.75	0.142857143	0	1	0.375
2816_OG5_130425_6 - PLANTS + FUNGI_YBR114W	YBR114W	RAD16 - Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad7p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex	1	0.0625	0	0.75	0.095238095	0	1	0.5625
2817_OG5_131747_6 - PLANTS + FUNGI_YMR090W	YMR090W	"YMR090W - Putative protein of unknown function with similarity to DTDP-glucose 4,6-dehydratases; GFP-fusion protein localizes to the cytoplasm; up-regulated in response to the fungicide mancozeb; not essential for viability"	1	0.125	0.138888889	1	0.142857143	0	0.7	0
2818_OG5_131274_6 - PLANTS + FUNGI_YDR051C	YDR051C	DET1 - Acid phosphatase involved in the non-vesicular transport of sterols in both directions between the endoplasmic reticulum and plasma membrane; deletion confers sensitivity to nickel	1	0	0	1	0.095238095	0	0.7	0.25
2819_OG5_134000_6 - PLANTS + FUNGI_YDR512C	YDR512C	"EMI1 - Non-essential protein required for transcriptional induction of the early meiotic-specific transcription factor IME1, also required for sporulation; contains twin cysteine-x9-cysteine motifs"	1	0	0	0.75	0.095238095	0	0.95	0.0625
2820_OG5_132592_6 - PLANTS + FUNGI_YDL109C	YDL109C	YDL109C - Putative lipase; involved in lipid metabolism; YDL109C is not an essential gene	1	0	0	0.875	0.095238095	0	0.8	0.0625
2821_OG5_133460_6 - PLANTS + FUNGI_YNL123W	YNL123W	NMA111 - Serine protease and general molecular chaperone; involved in response to heat stress and promotion of apoptosis; may contribute to lipid homeostasis; sequence similarity to the mammalian Omi/HtrA2 family of serine proteases	1	0	0.055555556	0.875	0	0	0.8	0.0625
2822_OG5_130793_6 - PLANTS + FUNGI_YDR533C	YDR533C	"HSP31 - Possible chaperone and cysteine protease with similarity to E. coli Hsp31; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease; exists as a dimer and contains a putative metal-binding site"	1	0.125	0.166666667	0.75	0.142857143	0	0.9	0
2823_OG5_134278_6 - PLANTS + FUNGI_YBR030W	YBR030W	RKM3 - Ribosomal lysine methyltransferase specific for monomethylation of Rpl42ap and Rpl42bp (lysine 40); nuclear SET domain containing protein	1	0	0	1	0.095238095	0	0.65	0
2824_OG5_133335_6 - PLANTS + FUNGI_YKL174C	YKL174C	TPO5 - Protein involved in excretion of putrescine and spermidine; putative polyamine transporter in the Golgi or post-Golgi vesicles	1	0	0	0.75	0	0	0.9	0
2825_OG5_128871_6 - PLANTS + FUNGI_YLR189C	YLR189C	"ATG26 - UDP-glucose:sterol glucosyltransferase, conserved enzyme involved in synthesis of sterol glucoside membrane lipids; in contrast to ATG26 from P. pastoris, S. cerevisiae ATG26 is not involved in autophagy"	1	0	0.138888889	0.75	0.19047619	0	0.9	0.0625
2826_OG5_131610_6 - PLANTS + FUNGI_YPL155C	YPL155C	"KIP2 - Kinesin-related motor protein involved in mitotic spindle positioning, stabilizes microtubules by targeting Bik1p to the plus end; Kip2p levels are controlled during the cell cycle"	1	0	0	0.625	0.238095238	0	1	0.1875
2827_OG5_131771_6 - PLANTS + FUNGI_YLR361C	YLR361C	"DCR2 - Phosphoesterase involved in downregulation of the unfolded protein response, at least in part via dephosphorylation of Ire1p; dosage-dependent positive regulator of the G1/S phase transition through control of the timing of START"	1	0	0	0.625	0.095238095	0	1	0.0625
2828_OG5_133501_6 - PLANTS + FUNGI_YJR052W	YJR052W	RAD7 - Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad16p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex	1	0	0	0.625	0.095238095	0	1	0
2829_OG5_131881_6 - PLANTS + FUNGI_YGR203W	YGR203W	"YCH1 - Phosphatase with sequence similarity to Cdc25p, Arr2p and Mih1p; member of the single-domain rhodanese homology superfamily; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus"	1	0	0	0.625	0.047619048	0	1	0.25
2830_OG5_134513_6 - PLANTS + FUNGI_YDL183C	YDL183C	YDL183C - Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene	1	0	0	0.625	0	0	1	0
2831_OG5_134816_6 - PLANTS + FUNGI_YGR147C	YGR147C	NAT2 - Protein with an apparent role in acetylation of N-terminal methionine residues	1	0	0	0.625	0	0	1	0
2832_OG5_131516_6 - PLANTS + FUNGI_YJL129C	YJL129C	"TRK1 - Component of the Trk1p-Trk2p potassium transport system; 180 kDa high affinity potassium transporter; phosphorylated in vivo and interacts physically with the phosphatase Ppz1p, suggesting Trk1p acitivy is regulated by phosphorylation"	1	0	0.055555556	0.625	0.19047619	0	1	0
2833_OG5_131516_6 - PLANTS + FUNGI_YKR050W	YKR050W	TRK2 - Component of the Trk1p-Trk2p potassium transport system	1	0	0.055555556	0.625	0.19047619	0	1	0
2834_OG5_131387_6 - PLANTS + FUNGI_YHR134W	YHR134W	WSS1 - Sumoylated protein that localizes to a single spot on the nuclear periphery of mother cells but not daughters; interacts genetically with SMT3; UV-sensitive mutant phenotype and genetic interactions suggest a role in the DNA damage response	1	0	0	0.75	0.142857143	0	0.85	0.25
2835_OG5_134951_6 - PLANTS + FUNGI_YGR215W	YGR215W	RSM27 - Mitochondrial ribosomal protein of the small subunit	1	0	0	0.75	0.047619048	0	0.85	0
2836_OG5_129625_6 - PLANTS + FUNGI_YGL114W	YGL114W	YGL114W - Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters	1	0.0625	0.166666667	0.625	0.047619048	0	0.95	0
2837_OG5_131648_6 - PLANTS + FUNGI_YPL279C	YPL279C	YPL279C - Putative protein of unknown function	1	0	0	0.625	0.19047619	0.071428571	0.95	0.125
2838_OG5_131648_6 - PLANTS + FUNGI_YOR390W	YOR390W	YOR390W - Putative protein of unknown function	1	0	0	0.625	0.19047619	0.071428571	0.95	0.125
2839_OG5_134269_6 - PLANTS + FUNGI_YPL107W	YPL107W	YPL107W - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YPL107W is not an essential gene	1	0	0	0.625	0.095238095	0	0.95	0.0625
2840_OG5_134525_6 - PLANTS + FUNGI_YJL145W	YJL145W	"SFH5 - Non-classical phosphatidylinositol transfer protein (PITP); exhibits PI- but not PC-transfer activity; localizes to the peripheral endoplasmic reticulum, cytosol and microsomes; similar to Sec14p"	1	0	0	0.625	0.047619048	0	0.95	0.0625
2841_OG5_130211_6 - PLANTS + FUNGI_YKL150W	YKL150W	"MCR1 - Mitochondrial NADH-cytochrome b5 reductase, involved in ergosterol biosynthesis"	1	0.0625	0	0.625	0.047619048	0	0.95	0.25
2842_OG5_130212_6 - PLANTS + FUNGI_YGR133W	YGR133W	PEX4 - Peroxisomal ubiquitin conjugating enzyme required for peroxisomal matrix protein import and peroxisome biogenesis	1	0	0	0.75	0.19047619	0	0.8	0.8125
2843_OG5_130747_6 - PLANTS + FUNGI_YLR144C	YLR144C	"ACF2 - Intracellular beta-1,3-endoglucanase, expression is induced during sporulation; may have a role in cortical actin cytoskeleton assembly"	1	0	0	0.75	0	0	0.8	0.0625
2844_OG5_130747_6 - PLANTS + FUNGI_YNR067C	YNR067C	"DSE4 - Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother"	1	0	0	0.75	0	0	0.8	0.0625
2845_OG5_132537_6 - PLANTS + FUNGI_YMR315W	YMR315W	YMR315W - Protein with NADP(H) oxidoreductase activity; transcription is regulated by Stb5p in response to NADPH depletion induced by diamide; promoter contains a putative Stb5p binding site	1	0.1875	0.083333333	0.75	0	0	0.8	0
2846_OG5_130967_6 - PLANTS + FUNGI_YLR126C	YLR126C	YLR126C - Putative protein of unknown function with similarity to glutamine amidotransferase proteins; has Aft1p-binding motif in the promoter; may be involved in copper and iron homeostasis; YLR126C is not an essential protein	1	0.1875	0.055555556	0.625	0.238095238	0	0.9	0.125
2847_OG5_129819_6 - PLANTS + FUNGI_YPL226W	YPL226W	NEW1 - ATP binding cassette protein that cosediments with polysomes and is required for biogenesis of the small ribosomal subunit; Asn/Gln-rich rich region supports [NU+] prion formation and susceptibility to [PSI+] prion induction	1	0.1875	0.027777778	0.5	0.095238095	0	1	0.0625
2848_OG5_129819_6 - PLANTS + FUNGI_YNL014W	YNL014W	HEF3 - Translational elongation factor EF-3; paralog of YEF3 and member of the ABC superfamily; stimulates EF-1 alpha-dependent binding of aminoacyl-tRNA by the ribosome; normally expressed in zinc deficient cells	1	0.1875	0.027777778	0.5	0.095238095	0	1	0.0625
2849_OG5_129819_6 - PLANTS + FUNGI_YLR249W	YLR249W	"YEF3 - Gamma subunit of translational elongation factor eEF1B, stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing eEF1A (Tef1p/Tef2p) from the ribosomal complex; contains two ABC cassettes; binds and hydrolyzes ATP"	1	0.1875	0.027777778	0.5	0.095238095	0	1	0.0625
2850_OG5_135380_6 - PLANTS + FUNGI_YOR131C	YOR131C	YOR131C - Putative protein of unknown function; non-essential gene; overexpression causes a cell cycle delay or arrest	1	0.0625	0.027777778	1	0.142857143	0	0.5	0
2851_OG5_131591_6 - PLANTS + FUNGI_YDL006W	YDL006W	"PTC1 - Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p, inactivating osmosensing MAPK cascade; involved in Fus3p activation during pheromone response; deletion affects precursor tRNA splicing, mitochondrial inheritance, and sporulation"	1	0	0	0.5	0.238095238	0	1	0.1875
2852_OG5_130607_6 - PLANTS + FUNGI_YMR266W	YMR266W	RSN1 - Membrane protein of unknown function; overexpression suppresses NaCl sensitivity of sro7 mutant cells by restoring sodium pump (Ena1p) localization to the plasma membrane	1	0	0	0.5	0.142857143	0	1	0.0625
2853_OG5_130607_6 - PLANTS + FUNGI_YOL084W	YOL084W	"PHM7 - Protein of unknown function, expression is regulated by phosphate levels; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole"	1	0	0	0.5	0.142857143	0	1	0.0625
2854_OG5_132929_6 - PLANTS + FUNGI_YBR287W	YBR287W	YBR287W - Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the ER; YBR287W is not an essential gene	1	0	0	0.5	0.142857143	0	1	0
2855_OG5_130622_6 - PLANTS + FUNGI_YJL012C	YJL012C	VTC4 - Vacuolar membrane polyphosphate polymerase; subunit of the vacuolar transporter chaperone (VTC) complex involved in synthesis and transfer of polyP to the vacuole; regulates membrane trafficking; role in non-autophagic vacuolar fusion	1	0	0	0.5	0.047619048	0	1	0.5625
2856_OG5_134825_6 - PLANTS + FUNGI_YKL049C	YKL049C	"CSE4 - Centromere protein that resembles histone H3, required for proper kinetochore function; homolog of human CENP-A; levels are regulated by E3 ubiquitin ligase Psh1p"	1	0	0	0.5	0.047619048	0	1	0
2857_OG5_134248_6 - PLANTS + FUNGI_YLR006C	YLR006C	SSK1 - Cytoplasmic response regulator; part of a two-component signal transducer that mediates osmosensing via a phosphorelay mechanism; required for mitophagy; dephosphorylated form is degraded by the ubiquitin-proteasome system; potential Cdc28p substrate	1	0	0.027777778	0.5	0	0	1	0
2858_OG5_134272_6 - PLANTS + FUNGI_YIL096C	YIL096C	YIL096C - Putative protein of unknown function; associates with precursors of the 60S ribosomal subunit; predicted to be involved in ribosome biogenesis	1	0	0	0.5	0	0	1	0.0625
2859_OG5_126798_6 - PLANTS + FUNGI_YJL214W	YJL214W	"HXT8 - Protein of unknown function with similarity to hexose transporter family members, expression is induced by low levels of glucose and repressed by high levels of glucose"	1	0	0.055555556	0.5	0.142857143	0	1	0.1875
2860_OG5_126798_6 - PLANTS + FUNGI_YDL194W	YDL194W	SNF3 - Plasma membrane low glucose sensor that regulates glucose transport; contains 12 predicted transmembrane segments and a long C-terminal tail required for induction of hexose transporters; also senses fructose and mannose; similar to Rgt2p	1	0	0.055555556	0.5	0.142857143	0	1	0.1875
2861_OG5_126798_6 - PLANTS + FUNGI_YHR096C	YHR096C	"HXT5 - Hexose transporter with moderate affinity for glucose, induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs"	1	0	0.055555556	0.5	0.142857143	0	1	0.1875
2862_OG5_126798_6 - PLANTS + FUNGI_YMR011W	YMR011W	"HXT2 - High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose"	1	0	0.055555556	0.5	0.142857143	0	1	0.1875
2863_OG5_126798_6 - PLANTS + FUNGI_YDL138W	YDL138W	RGT2 - Plasma membrane high glucose sensor that regulates glucose transport; contains 12 predicted transmembrane segments and a long C-terminal tail required for induction of hexose transporters; highly similar to Snf3p	1	0	0.055555556	0.5	0.142857143	0	1	0.1875
2864_OG5_126798_6 - PLANTS + FUNGI_YDR345C	YDR345C	"HXT3 - Low affinity glucose transporter of the major facilitator superfamily, expression is induced in low or high glucose conditions"	1	0	0.055555556	0.5	0.142857143	0	1	0.1875
2865_OG5_126798_6 - PLANTS + FUNGI_YHR094C	YHR094C	"HXT1 - Low-affinity glucose transporter of the major facilitator superfamily, expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting"	1	0	0.055555556	0.5	0.142857143	0	1	0.1875
2866_OG5_126798_6 - PLANTS + FUNGI_YLR081W	YLR081W	"GAL2 - Galactose permease, required for utilization of galactose; also able to transport glucose"	1	0	0.055555556	0.5	0.142857143	0	1	0.1875
2867_OG5_126798_6 - PLANTS + FUNGI_YNR072W	YNR072W	"HXT17 - Hexose transporter, up-regulated in media containing raffinose and galactose at pH 7.7 versus pH 4.7, repressed by high levels of glucose"	1	0	0.055555556	0.5	0.142857143	0	1	0.1875
2868_OG5_126798_6 - PLANTS + FUNGI_YFL011W	YFL011W	"HXT10 - Putative hexose transporter, expressed at low levels and expression is repressed by glucose"	1	0	0.055555556	0.5	0.142857143	0	1	0.1875
2869_OG5_126798_6 - PLANTS + FUNGI_YHR092C	YHR092C	"HXT4 - High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose"	1	0	0.055555556	0.5	0.142857143	0	1	0.1875
2870_OG5_126798_6 - PLANTS + FUNGI_YDL245C	YDL245C	"HXT15 - Protein of unknown function with similarity to hexose transporter family members, expression is induced by low levels of glucose and repressed by high levels of glucose"	1	0	0.055555556	0.5	0.142857143	0	1	0.1875
2871_OG5_126798_6 - PLANTS + FUNGI_YJR158W	YJR158W	"HXT16 - Protein of unknown function with similarity to hexose transporter family members, expression is repressed by high levels of glucose"	1	0	0.055555556	0.5	0.142857143	0	1	0.1875
2872_OG5_126798_6 - PLANTS + FUNGI_YDR342C	YDR342C	"HXT7 - High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels"	1	0	0.055555556	0.5	0.142857143	0	1	0.1875
2873_OG5_126798_6 - PLANTS + FUNGI_YDR343C	YDR343C	"HXT6 - High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of expression by high glucose requires SNF3"	1	0	0.055555556	0.5	0.142857143	0	1	0.1875
2874_OG5_126798_6 - PLANTS + FUNGI_YEL069C	YEL069C	"HXT13 - Hexose transporter, induced in the presence of non-fermentable carbon sources, induced by low levels of glucose, repressed by high levels of glucose"	1	0	0.055555556	0.5	0.142857143	0	1	0.1875
2875_OG5_126798_6 - PLANTS + FUNGI_YJL219W	YJL219W	"HXT9 - Putative hexose transporter that is nearly identical to Hxt11p, has similarity to major facilitator superfamily (MFS) transporters, expression of HXT9 is regulated by transcription factors Pdr1p and Pdr3p"	1	0	0.055555556	0.5	0.142857143	0	1	0.1875
2876_OG5_126798_6 - PLANTS + FUNGI_YOL156W	YOL156W	"HXT11 - Putative hexose transporter that is nearly identical to Hxt9p, has similarity to major facilitator superfamily (MFS) transporters and is involved in pleiotropic drug resistance"	1	0	0.055555556	0.5	0.142857143	0	1	0.1875
2877_OG5_129855_6 - PLANTS + FUNGI_YOR161C	YOR161C	"PNS1 - Protein of unknown function; has similarity to Torpedo californica tCTL1p, which is postulated to be a choline transporter, neither null mutation nor overexpression affects choline transport"	1	0	0	0.625	0.142857143	0.071428571	0.85	0.3125
2878_OG5_129626_6 - PLANTS + FUNGI_YER048C	YER048C	"CAJ1 - Nuclear type II J heat shock protein of the E. coli dnaJ family, contains a leucine zipper-like motif, binds to non-native substrates for presentation to Ssa3p, may function during protein translocation, assembly and disassembly"	1	0	0	1	0.142857143	0	0.45	0.625
2879_OG5_129217_6 - PLANTS + FUNGI_YJL212C	YJL212C	OPT1 - Proton-coupled oligopeptide transporter of the plasma membrane; also transports glutathione and phytochelatin; member of the OPT family	1	0	0	0.5	0	0	0.95	0
2880_OG5_134799_6 - PLANTS + FUNGI_YPR185W	YPR185W	"ATG13 - Regulatory subunit of the Atg1p signaling complex; stimulates Atg1p kinase activity; required for vesicle formation during autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; involved in Atg9p, Atg23p, and Atg27p cycling"	1	0	0	0.5	0	0	0.95	0.0625
2881_OG5_131773_6 - PLANTS + FUNGI_YMR220W	YMR220W	"ERG8 - Phosphomevalonate kinase, an essential cytosolic enzyme that acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate"	1	0.125	0	0.5	0.142857143	0	0.95	0.3125
2882_OG5_131022_6 - PLANTS + FUNGI_YMR166C	YMR166C	YMR166C - Predicted transporter of the mitochondrial inner membrane; has similarity to human mitochondrial ATP-Mg/Pi carriers; YMR166C is not an essential gene	1	0	0	0.625	0.142857143	0	0.8	0.375
2883_OG5_132594_6 - PLANTS + FUNGI_YOR155C	YOR155C	"ISN1 - Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase, catalyzes the breakdown of IMP to inosine, does not show similarity to known 5'-nucleotidases from other organisms"	1	0	0	0.625	0.047619048	0	0.8	0.25
2884_OG5_131168_6 - PLANTS + FUNGI_YKL128C	YKL128C	"PMU1 - Putative phosphomutase, contains a region homologous to the active site of phosphomutases; overexpression suppresses the histidine auxotrophy of an ade3 ade16 ade17 triple mutant and the temperature sensitivity of a tps2 mutant"	1	0	0	0.5	0.047619048	0	0.9	0.0625
2885_OG5_133694_6 - PLANTS + FUNGI_YMR193W	YMR193W	MRPL24 - Mitochondrial ribosomal protein of the large subunit	1	0	0.111111111	0.5	0.095238095	0	0.9	0.0625
2886_OG5_131528_6 - PLANTS + FUNGI_YNL032W	YNL032W	SIW14 - Tyrosine phosphatase that plays a role in actin filament organization and endocytosis; localized to the cytoplasm	1	0	0.027777778	0.5	0.095238095	0	0.9	0.3125
2887_OG5_131100_6 - PLANTS + FUNGI_YDR161W	YDR161W	YDR161W - Putative protein of unknown function; non-essential gene; proposed function in rRNA and ribosome biosynthesis based on transcriptional co-regulation; genetic interactions suggest a role in ER-associated protein degradation (ERAD)	1	0	0	0.375	0.333333333	0	1	0.4375
2888_OG5_130969_6 - PLANTS + FUNGI_YER072W	YER072W	"VTC1 - Subunit of the vacuolar transporter chaperone (VTC) complex involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion; also has mRNA binding activity"	1	0	0	0.375	0.142857143	0	1	0.3125
2889_OG5_131085_6 - PLANTS + FUNGI_YLR285W	YLR285W	"NNT1 - Putative nicotinamide N-methyltransferase, has a role in rDNA silencing and in lifespan determination"	1	0	0	0.375	0.142857143	0	1	0.3125
2890_OG5_132753_6 - PLANTS + FUNGI_YML064C	YML064C	TEM1 - GTP-binding protein of the ras superfamily involved in termination of M-phase; controls actomyosin and septin dynamics during cytokinesis	1	0	0	0.375	0.142857143	0	1	0.1875
2891_OG5_134186_6 - PLANTS + FUNGI_YMR014W	YMR014W	"BUD22 - Protein required for 18S rRNA maturation and small ribosomal subunit biogenesis; cosediments with pre-ribosomal particles; mutation decreases efficiency of +1 Ty1 frameshifting and transposition, and affects budding pattern"	1	0	0	0.375	0.142857143	0	1	0.0625
2892_OG5_132414_6 - PLANTS + FUNGI_YLR241W	YLR241W	"YLR241W - Putative protein of unknown function, may be involved in detoxification"	1	0	0	0.375	0.095238095	0	1	0.1875
2893_OG5_130471_6 - PLANTS + FUNGI_YMR307W	YMR307W	"GAS1 - Beta-1,3-glucanosyltransferase, required for cell wall assembly and also has a role in transcriptional silencing; localizes to the cell surface via a glycosylphosphatidylinositol (GPI) anchor; also found at the nuclear periphery"	1	0	0	0.375	0.047619048	0	1	0.125
2894_OG5_129592_6 - PLANTS + FUNGI_YMR250W	YMR250W	"GAD1 - Glutamate decarboxylase, converts glutamate into gamma-aminobutyric acid (GABA) during glutamate catabolism; involved in response to oxidative stress"	1	0.0625	0.25	0.5	0.142857143	0	0.85	0.125
2895_OG5_130975_6 - PLANTS + FUNGI_YDL209C	YDL209C	"CWC2 - Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; binds directly to U6 snRNA; similar to S. pombe Cwf2"	1	0	0	0.375	0.285714286	0	0.95	0.5
2896_OG5_134514_6 - PLANTS + FUNGI_YEL040W	YEL040W	UTR2 - Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar to and functionally redundant with Crh1; glycosylphosphatidylinositol (GPI)-anchored protein localized to bud neck	1	0	0	0.375	0	0	0.95	0
2897_OG5_134514_6 - PLANTS + FUNGI_YLR213C	YLR213C	"CRR1 - Putative glycoside hydrolase of the spore wall envelope; required for normal spore wall assembly, possibly for cross-linking between the glucan and chitosan layers; expressed during sporulation"	1	0	0	0.375	0	0	0.95	0
2898_OG5_132797_6 - PLANTS + FUNGI_YNL191W	YNL191W	"DUG3 - Probable glutamine amidotransferase, forms a complex with Dug1p and Dug2p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p)"	1	0	0.194444444	0.375	0.095238095	0	0.95	0.0625
2899_OG5_133123_6 - PLANTS + FUNGI_YNL332W	YNL332W	"THI12 - Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13"	1	0	0.138888889	0.625	0.047619048	0	0.7	0
2900_OG5_133123_6 - PLANTS + FUNGI_YDL244W	YDL244W	"THI13 - Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13"	1	0	0.138888889	0.625	0.047619048	0	0.7	0
2901_OG5_133123_6 - PLANTS + FUNGI_YFL058W	YFL058W	"THI5 - Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13"	1	0	0.138888889	0.625	0.047619048	0	0.7	0
2902_OG5_133123_6 - PLANTS + FUNGI_YJR156C	YJR156C	"THI11 - Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13"	1	0	0.138888889	0.625	0.047619048	0	0.7	0
2903_OG5_130299_6 - PLANTS + FUNGI_YDR316W	YDR316W	OMS1 - Protein integral to the mitochondrial membrane; has a conserved methyltransferase motif; multicopy suppressor of respiratory defects caused by OXA1 mutations	1	0.0625	0	0.5	0.142857143	0	0.8	0.5625
2904_OG5_133334_6 - PLANTS + FUNGI_YGR266W	YGR266W	"YGR266W - Protein of unknown function, predicted to contain a single transmembrane domain; mutant has increased aneuploidy tolerance; localized to both the mitochondrial outer membrane and the plasma membrane"	1	0	0	0.375	0	0	0.9	0
2905_OG5_135760_6 - PLANTS + FUNGI_YBR271W	YBR271W	YBR271W - Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; predicted to be involved in ribosome biogenesis	1	0	0	0.375	0	0	0.9	0
2906_OG5_131531_6 - PLANTS + FUNGI_YML079W	YML079W	"YML079W - Non-essential protein of unknown function with structural resemblance to plant storage and ligand binding proteins (canavalin, glycinin, auxin binding protein) and to some enzymes (epimerase, germin); localizes to the nucleus and cytoplasm"	1	0.0625	0.25	0.75	0.19047619	0	0.5	0.125
2907_OG5_133111_6 - PLANTS + FUNGI_YHR206W	YHR206W	SKN7 - Nuclear response regulator and transcription factor; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; part of a branched two-component signaling system; required for optimal induction of heat-shock genes in response to oxidative stress; involved in osmoregulation	1	0.0625	0.138888889	0.25	0.047619048	0	1	0
2908_OG5_134267_6 - PLANTS + FUNGI_YOR299W	YOR299W	"BUD7 - Member of the ChAPs family of proteins (Chs5p-Arf1p-binding proteins: Bch1p, Bch2p, Bud7p, Chs6p), that forms the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane"	1	0	0	0.25	0.19047619	0	1	0
2909_OG5_134267_6 - PLANTS + FUNGI_YMR237W	YMR237W	"BCH1 - Member of the ChAPs family (Chs5p-Arf1p-binding proteins: Bch1p, Bch2p, Bud7p, Chs6p), that forms the exomer complex with Chs5p to mediate export of specific cargo proteins from the Golgi to the plasma membrane; may interact with ribosomes"	1	0	0	0.25	0.19047619	0	1	0
2910_OG5_131935_6 - PLANTS + FUNGI_YBR106W	YBR106W	"PHO88 - Probable membrane protein, involved in phosphate transport; pho88 pho86 double null mutant exhibits enhanced synthesis of repressible acid phosphatase at high inorganic phosphate concentrations"	1	0	0	0.25	0.142857143	0	1	0.1875
2911_OG5_132041_6 - PLANTS + FUNGI_YMR241W	YMR241W	"YHM2 - Carrier protein that exports citrate from and imports oxoglutarate into the mitochondrion, causing net export of NADPH reducing equivalents; also associates with mt nucleoids and has a role in replication and segregation of the mt genome"	1	0	0	0.25	0.142857143	0	1	0.3125
2912_OG5_134176_6 - PLANTS + FUNGI_YKL054C	YKL054C	"DEF1 - RNAPII degradation factor, forms a complex with Rad26p in chromatin, enables ubiquitination and proteolysis of RNAPII present in an elongation complex; mutant is deficient in Zip1p loading onto chromosomes during meiosis"	1	0	0	0.25	0.142857143	0	1	0.0625
2913_OG5_134527_6 - PLANTS + FUNGI_YBR141C	YBR141C	YBR141C - Putative S-adenosylmethionine-dependent methyltransferase; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; YBR141C is not an essential gene	1	0	0	0.25	0.142857143	0	1	0.0625
2914_OG5_135051_6 - PLANTS + FUNGI_YMR269W	YMR269W	TMA23 - Nucleolar protein implicated in ribosome biogenesis; deletion extends chronological lifespan	1	0	0	0.25	0	0.142857143	1	0
2915_OG5_134821_6 - PLANTS + FUNGI_YNL277W	YNL277W	"MET2 - L-homoserine-O-acetyltransferase, catalyzes the conversion of homoserine to O-acetyl homoserine which is the first step of the methionine biosynthetic pathway"	1	0	0	0.25	0.095238095	0	1	0.0625
2916_OG5_134517_6 - PLANTS + FUNGI_YPL105C	YPL105C	"SYH1 - Protein of unknown function that influences nuclear pore distribution; co-purifies with ribosomes; contains a GYF domain, which bind proline-rich sequences; deletion extends chronological lifespan"	1	0	0.027777778	0.25	0	0	1	0.125
2917_OG5_134517_6 - PLANTS + FUNGI_YBR172C	YBR172C	SMY2 - Protein of unknown function involved in COPII vesicle formation; interacts with the Sec23p/Sec24p subcomplex; overexpression suppresses the temperature sensitivity of a myo2 mutant; has similarity to S. pombe Mpd2	1	0	0.027777778	0.25	0	0	1	0.125
2918_OG5_134529_6 - PLANTS + FUNGI_YNL197C	YNL197C	WHI3 - RNA binding protein that sequesters CLN3 mRNA in cytoplasmic foci; cytoplasmic retention factor for Cdc28p and associated cyclins; regulates cell fate and dose-dependently regulates the critical cell size required for passage through Start	1	0	0	0.25	0	0	1	0
2919_OG5_134529_6 - PLANTS + FUNGI_YDL224C	YDL224C	WHI4 - Putative RNA binding protein and partially redundant Whi3p homolog that regulates the cell size requirement for passage through Start and commitment to cell division	1	0	0	0.25	0	0	1	0
2920_OG5_134779_6 - PLANTS + FUNGI_YDR399W	YDR399W	"HPT1 - Dimeric hypoxanthine-guanine phosphoribosyltransferase, catalyzes the formation of both inosine monophosphate and guanosine monophosphate; mutations in the human homolog HPRT1 can cause Lesch-Nyhan syndrome and Kelley-Seegmiller syndrome"	1	0	0	0.25	0	0	1	0
2921_OG5_134779_6 - PLANTS + FUNGI_YJR133W	YJR133W	"XPT1 - Xanthine-guanine phosphoribosyl transferase, required for xanthine utilization and for optimal utilization of guanine"	1	0	0	0.25	0	0	1	0
2922_OG5_135417_6 - PLANTS + FUNGI_YDR393W	YDR393W	"SHE9 - Mitochondrial inner membrane protein required for normal mitochondrial morphology, may be involved in fission of the inner membrane; forms a homo-oligomeric complex"	1	0	0	0.25	0	0	1	0.0625
2923_OG5_135766_6 - PLANTS + FUNGI_YBR166C	YBR166C	"TYR1 - Prephenate dehydrogenase involved in tyrosine biosynthesis, expression is dependent on phenylalanine levels"	1	0	0	0.25	0	0	1	0
2924_OG5_131694_6 - PLANTS + FUNGI_YOR388C	YOR388C	"FDH1 - NAD(+)-dependent formate dehydrogenase, may protect cells from exogenous formate"	1	0	0.055555556	0.5	0.047619048	0	0.75	0.0625
2925_OG5_136405_6 - PLANTS + FUNGI_YMR020W	YMR020W	"FMS1 - Polyamine oxidase, converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis"	1	0	0	0.875	0	0	0.35	0
2926_OG5_135587_6 - PLANTS + FUNGI_YNL242W	YNL242W	"ATG2 - Peripheral membrane protein required for vesicle formation during autophagy, pexophagy, and the cytoplasm-to-vaucole targeting (Cvt) pathway; involved in Atg9p cycling between the phagophore assembly site and mitochondria"	1	0	0	0.375	0.095238095	0	0.85	0
2927_OG5_132933_6 - PLANTS + FUNGI_YDR525W-A	YDR525W-A	"SNA2 - Protein of unknown function, has similarity to Pmp3p, which is involved in cation transport; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern"	1	0	0	0.25	0.142857143	0	0.95	0
2928_OG5_132933_6 - PLANTS + FUNGI_YDL123W	YDL123W	"SNA4 - Protein of unknown function, localized to the vacuolar outer membrane; predicted to be palmitoylated"	1	0	0	0.25	0.142857143	0	0.95	0
2929_OG5_132303_6 - PLANTS + FUNGI_YMR155W	YMR155W	YMR155W - Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen	1	0	0	0.25	0.095238095	0	0.95	0.125
2930_OG5_134910_6 - PLANTS + FUNGI_YOR292C	YOR292C	YOR292C - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YOR292C is not an essential gene	1	0	0	0.25	0.095238095	0	0.95	0.0625
2931_OG5_135292_6 - PLANTS + FUNGI_YJR062C	YJR062C	"NTA1 - Amidase, removes the amide group from N-terminal asparagine and glutamine residues to generate proteins with N-terminal aspartate and glutamate residues that are targets of ubiquitin-mediated degradation"	1	0	0	0.25	0.047619048	0	0.95	0.0625
2932_OG5_135678_6 - PLANTS + FUNGI_YFR048W	YFR048W	RMD8 - Cytosolic protein required for sporulation	1	0	0	0.25	0.047619048	0	0.95	0
2933_OG5_136052_6 - PLANTS + FUNGI_YBR268W	YBR268W	MRPL37 - Mitochondrial ribosomal protein of the large subunit	1	0	0	0.25	0	0	0.95	0
2934_OG5_135432_6 - PLANTS + FUNGI_YMR068W	YMR068W	"AVO2 - Component of a complex containing the Tor2p kinase and other proteins, which may have a role in regulation of cell growth"	1	0	0	0.375	0.095238095	0	0.8	0
2935_OG5_130746_6 - PLANTS + FUNGI_YLR286C	YLR286C	"CTS1 - Endochitinase, required for cell separation after mitosis; transcriptional activation during the G1 phase of the cell cycle is mediated by transcription factor Ace2p"	1	0	0	0.375	0.047619048	0	0.8	0.0625
2936_OG5_132365_6 - PLANTS + FUNGI_YJR075W	YJR075W	"HOC1 - Alpha-1,6-mannosyltransferase involved in cell wall mannan biosynthesis; subunit of a Golgi-localized complex that also contains Anp1p, Mnn9p, Mnn11p, and Mnn10p; identified as a suppressor of a cell lysis sensitive pkc1-371 allele"	1	0	0	0.25	0.142857143	0.071428571	0.9	0
2937_OG5_132365_6 - PLANTS + FUNGI_YGL038C	YGL038C	"OCH1 - Mannosyltransferase of the cis-Golgi apparatus, initiates the polymannose outer chain elongation of N-linked oligosaccharides of glycoproteins"	1	0	0	0.25	0.142857143	0.071428571	0.9	0
2938_OG5_130804_6 - PLANTS + FUNGI_YGR143W	YGR143W	SKN1 - Protein involved in sphingolipid biosynthesis; type II membrane protein with similarity to Kre6p	1	0	0	0.25	0.047619048	0	0.9	0
2939_OG5_130804_6 - PLANTS + FUNGI_YPR159W	YPR159W	"KRE6 - Type II integral membrane protein required for beta-1,6 glucan biosynthesis; putative beta-glucan synthase; localizes to the ER, plasma membrane, sites of polarized growth and secretory vesicles; functionally redundant with Skn1p"	1	0	0	0.25	0.047619048	0	0.9	0
2940_OG5_135924_6 - PLANTS + FUNGI_YPR157W	YPR157W	TDA6 - Putative protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation; null mutant is sensitive to expression of the top1-T722A allele	1	0	0	0.25	0	0	0.9	0
2941_OG5_135924_6 - PLANTS + FUNGI_YGR141W	YGR141W	VPS62 - Vacuolar protein sorting (VPS) protein required for cytoplasm to vacuole targeting of proteins	1	0	0	0.25	0	0	0.9	0
2942_OG5_128979_6 - PLANTS + FUNGI_YDR039C	YDR039C	"ENA2 - P-type ATPase sodium pump, involved in Na+ efflux to allow salt tolerance; likely not involved in Li+ efflux"	1	0	0.055555556	0.25	0.095238095	0	0.9	0.625
2943_OG5_128979_6 - PLANTS + FUNGI_YDR040C	YDR040C	"ENA1 - P-type ATPase sodium pump, involved in Na+ and Li+ efflux to allow salt tolerance"	1	0	0.055555556	0.25	0.095238095	0	0.9	0.625
2944_OG5_128979_6 - PLANTS + FUNGI_YDR038C	YDR038C	"ENA5 - Protein with similarity to P-type ATPase sodium pumps, member of the Na+ efflux ATPase family"	1	0	0.055555556	0.25	0.095238095	0	0.9	0.625
2945_OG5_134684_6 - PLANTS + FUNGI_YJR060W	YJR060W	"CBF1 - Helix-loop-helix protein that binds the motif CACRTG, which is present at several sites including MET gene promoters and centromere DNA element I (CDEI); required for nucleosome positioning at this motif; targets Isw1p to DNA"	1	0	0.027777778	0.25	0.095238095	0	0.9	0
2946_OG5_132752_6 - PLANTS + FUNGI_YPL057C	YPL057C	"SUR1 - Probable catalytic subunit of a mannosylinositol phosphorylceramide (MIPC) synthase, forms a complex with probable regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p"	1	0	0.055555556	0.25	0.142857143	0	0.9	0.0625
2947_OG5_132752_6 - PLANTS + FUNGI_YBR161W	YBR161W	"CSH1 - Probable catalytic subunit of a mannosylinositol phosphorylceramide (MIPC) synthase, forms a complex with probable regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Sur1p"	1	0	0.055555556	0.25	0.142857143	0	0.9	0.0625
2948_OG5_132043_6 - PLANTS + FUNGI_YDR530C	YDR530C	"APA2 - Diadenosine 5',5''-P1,P4-tetraphosphate phosphorylase II (AP4A phosphorylase), involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; has similarity to Apa1p"	1	0	0.027777778	0.25	0.142857143	0	0.9	0.1875
2949_OG5_132043_6 - PLANTS + FUNGI_YCL050C	YCL050C	"APA1 - Diadenosine 5',5''-P1,P4-tetraphosphate phosphorylase I (AP4A phosphorylase), involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; has similarity to Apa2p"	1	0	0.027777778	0.25	0.142857143	0	0.9	0.1875
2950_OG5_136801_6 - PLANTS + FUNGI_YFL031W	YFL031W	"HAC1 - Basic leucine zipper (bZIP) transcription factor (ATF/CREB1 homolog) that regulates the unfolded protein response, via UPRE binding, and membrane biogenesis; ER stress-induced splicing pathway facilitates efficient Hac1p synthesis"	1	0	0	0.625	0.095238095	0	0.5	0
2951_OG5_133764_6 - PLANTS + FUNGI_YGR189C	YGR189C	CRH1 - Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar and functionally redundant to Utr2; localizes to sites of polarized growth; expression induced by cell wall stress	1	0	0	0.375	0	0.071428571	0.75	0
2952_OG5_132125_6 - PLANTS + FUNGI_YDL210W	YDL210W	UGA4 - Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane	1	0	0	0.375	0	0	0.75	0
2953_OG5_133529_6 - PLANTS + FUNGI_YOR311C	YOR311C	"DGK1 - Diacylglycerol kinase, localized to the endoplasmic reticulum (ER); overproduction induces enlargement of ER-like membrane structures and suppresses a temperature-sensitive sly1 mutation; contains a CTP transferase domain"	1	0	0.083333333	0.125	0.19047619	0	1	0.0625
2954_OG5_132150_6 - PLANTS + FUNGI_YNL104C	YNL104C	LEU4 - Alpha-isopropylmalate synthase (2-isopropylmalate synthase); the main isozyme responsible for the first step in the leucine biosynthesis pathway	1	0	0.222222222	0.125	0.047619048	0	1	0
2955_OG5_132150_6 - PLANTS + FUNGI_YOR108W	YOR108W	"LEU9 - Alpha-isopropylmalate synthase II (2-isopropylmalate synthase), catalyzes the first step in the leucine biosynthesis pathway; the minor isozyme, responsible for the residual alpha-IPMS activity detected in a leu4 null mutant"	1	0	0.222222222	0.125	0.047619048	0	1	0
2956_OG5_131865_6 - PLANTS + FUNGI_YIL164C	YIL164C	"NIT1 - Nitrilase, member of the nitrilase branch of the nitrilase superfamily; in closely related species and other S. cerevisiae strain backgrounds YIL164C and adjacent ORF, YIL165C, likely constitute a single ORF encoding a nitrilase gene"	1	0	0.055555556	0.5	0.095238095	0	0.6	0.125
2957_OG5_142807_6 - PLANTS + FUNGI_YJL193W	YJL193W	"YJL193W - Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect"	1	0	0	1	0	0	0.1	0
2958_OG5_132599_6 - PLANTS + FUNGI_YOR215C	YOR215C	AIM41 - Putative protein of unknown function; the authentic protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss	1	0	0.527777778	0.375	0	0	0.7	0
2959_OG5_132304_6 - PLANTS + FUNGI_YER185W	YER185W	PUG1 - Plasma membrane protein with roles in the uptake of protoprophyrin IX and the efflux of heme; expression is induced under both low-heme and low-oxygen conditions; member of the fungal lipid-translocating exporter (LTE) family of proteins	1	0	0	0.25	0.047619048	0	0.8	0
2960_OG5_132304_6 - PLANTS + FUNGI_YGR213C	YGR213C	RTA1 - Protein involved in 7-aminocholesterol resistance; has seven potential membrane-spanning regions; expression is induced under both low-heme and low-oxygen conditions; member of the fungal lipid-translocating exporter (LTE) family of protein	1	0	0	0.25	0.047619048	0	0.8	0
2961_OG5_133540_6 - PLANTS + FUNGI_YLR300W	YLR300W	"EXG1 - Major exo-1,3-beta-glucanase of the cell wall, involved in cell wall beta-glucan assembly; exists as three differentially glycosylated isoenzymes"	1	0	0	0.25	0.047619048	0	0.8	0.0625
2962_OG5_133540_6 - PLANTS + FUNGI_YOR190W	YOR190W	"SPR1 - Sporulation-specific exo-1,3-beta-glucanase; contributes to ascospore thermoresistance"	1	0	0	0.25	0.047619048	0	0.8	0.0625
2963_OG5_137442_6 - PLANTS + FUNGI_YGL059W	YGL059W	PKP2 - Mitochondrial protein kinase that negatively regulates activity of the pyruvate dehydrogenase complex by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp1p and phosphatases Ptc5p and Ptc6p	1	0	0	0.25	0.047619048	0	0.8	0
2964_OG5_132308_6 - PLANTS + FUNGI_YDL057W	YDL057W	YDL057W - Putative protein of unknown function; YDL057W is not an essential gene	1	0	0.194444444	0.25	0	0	0.8	0.125
2965_OG5_132300_6 - PLANTS + FUNGI_YGR178C	YGR178C	"PBP1 - Component of glucose deprivation induced stress granules, involved in P-body-dependent granule assembly; similar to human ataxin-2; interacts with Pab1p to regulate mRNA polyadenylation; interacts with Mkt1p to regulate HO translation"	1	0	0	0.625	0.142857143	0	0.4	0.5
2966_OG5_136806_6 - PLANTS + FUNGI_YJL093C	YJL093C	"TOK1 - Outward-rectifier potassium channel of the plasma membrane with two pore domains in tandem, each of which forms a functional channel permeable to potassium; carboxy tail functions to prevent inner gate closures; target of K1 toxin"	1	0	0	0.375	0.047619048	0	0.65	0
2967_OG5_130068_6 - PLANTS + FUNGI_YJR153W	YJR153W	"PGU1 - Endo-polygalacturonase, pectolytic enzyme that hydrolyzes the alpha-1,4-glycosidic bonds in the rhamnogalacturonan chains in pectins"	1	0	0.027777778	0.5	0.047619048	0	0.45	0.0625
2968_OG5_134289_6 - PLANTS + FUNGI_YLR068W	YLR068W	FYV7 - Essential protein required for maturation of 18S rRNA; required for survival upon exposure to K1 killer toxin	1	0	0	0.5	0.095238095	0	0.4	0.25
2969_OG5_137377_6 - PLANTS + FUNGI_YIL147C	YIL147C	"SLN1 - Histidine kinase osmosensor that regulates a MAP kinase cascade; transmembrane protein with an intracellular kinase domain that signals to Ypd1p and Ssk1p, thereby forming a phosphorelay system similar to bacterial two-component regulators"	1	0	0.027777778	0.25	0.047619048	0	0.6	0
2970_OG5_137945_6 - PLANTS + FUNGI_YLR149C	YLR149C	YLR149C - Putative protein of unknown function; overexpression causes a cell cycle delay or arrest; null mutation results in a decrease in plasma membrane electron transport; YLR149C is not an essential gene	1	0	0	0.25	0.047619048	0	0.55	0.0625
2971_OG5_141372_6 - PLANTS + FUNGI_YPL067C	YPL067C	YPL067C - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL067C is not an essential gene	1	0	0	0.25	0	0	0.55	0
2972_OG5_147207_6 - PLANTS + FUNGI_YGL092W	YGL092W	"NUP145 - Essential nucleoporin, catalyzes its own cleavage in vivo to generate a C-terminal fragment that assembles into the Nup84p subcomplex of the nuclear pore complex, and an N-terminal fragment of unknown function that is homologous to Nup100p"	1	0	0	0.25	0	0	0.4	0
2973_OG5_127968_6 - PLANTS + FUNGI_YLR154W-C	YLR154W-C	TAR1 - Mitochondrial protein potentially involved in regulation of respiratory metabolism; interacts genetically with RPO41 and physically with Coq5p; encoded within the 25S rRNA gene on the opposite strand	1	0	0	0.375	0.047619048	0	0.2	0.125
2974_OG5_144198_6 - PLANTS + FUNGI_YIR039C	YIR039C	"YPS6 - Putative GPI-anchored aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance"	1	0	0	0.5	0.142857143	0	0.05	0.0625
2975_OG5_164703_6 - PLANTS + FUNGI_Q0160	Q0160	"SCEI - I-SceI DNA endonuclease, encoded by the mitochondrial group I intron of the 21S_rRNA gene; mediates gene conversion that propagates the intron into intron-less copies of the 21S_rRNA gene"	1	0	0	0.5	0	0	0.05	0
2976_OG5_142324_6 - PLANTS + FUNGI_YNR064C	YNR064C	"YNR064C - Epoxide hydrolase, member of the alpha/beta hydrolase fold family; may have a role in detoxification of epoxides"	1	0	0.111111111	0.25	0.047619048	0	0.25	0
2977_OG5_137471_6 - PLANTS + FUNGI_YOL109W	YOL109W	ZEO1 - Peripheral membrane protein of the plasma membrane that interacts with Mid2p; regulates the cell integrity pathway mediated by Pkc1p and Slt2p; the authentic protein is detected in a phosphorylated state in highly purified mitochondria	1	0	0.027777778	0.375	0.142857143	0	0.05	0.125
2978_OG5_132479_6 - PLANTS + FUNGI_YDR055W	YDR055W	"PST1 - Cell wall protein that contains a putative GPI-attachment site; secreted by regenerating protoplasts; up-regulated by activation of the cell integrity pathway, as mediated by Rlm1p; upregulated by cell wall damage via disruption of FKS1"	1	0	0	0.375	0.047619048	0	0.05	0
2979_OG5_133779_6 - PLANTS + FUNGI_YJL186W	YJL186W	"MNN5 - Alpha-1,2-mannosyltransferase, responsible for addition of the second alpha-1,2-linked mannose of the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment"	1	0	0	0.25	0.095238095	0	0.1	0.0625
2980_OG5_158743_6 - PLANTS + FUNGI_YCR097W	YCR097W	HMRA1 - Silenced copy of a1 at HMR; homeobox corepressor that interacts with Alpha2p to repress haploid-specific gene transcription in diploid cells	1	0	0	0.25	0	0.071428571	0.05	0.125
2981_OG5_131264_6 - PLANTS + FUNGI_YNR033W	YNR033W	"ABZ1 - Para-aminobenzoate (PABA) synthase, has similarity to Escherichia coli PABA synthase components PabA and PabB; required for the synthesis of para-aminobenzoic acid, an important intermediate for folate and ubiquinone Q biosynthesis"	1	0	0.194444444	1	0.095238095	0	0.95	0.1875
2982_OG5_130972_6 - PLANTS + FUNGI_YER037W	YER037W	PHM8 - Lysophosphatidic acid (LPA) phosphatase involved in LPA hydrolysis in response to phosphate starvation; phosphatase activity is soluble and Mg2+ dependent; expression is induced by low phosphate levels and by inactivation of Pho85p	1	0	0.166666667	1	0.095238095	0	0.9	0.125
2983_OG5_130972_6 - PLANTS + FUNGI_YGL224C	YGL224C	"SDT1 - Pyrimidine nucleotidase; overexpression suppresses the 6-AU sensitivity of transcription elongation factor S-II, as well as resistance to other pyrimidine derivatives"	1	0	0.166666667	1	0.095238095	0	0.9	0.125
2984_OG5_134105_7 - FUNGI_YIL046W	YIL046W	"MET30 - F-box protein containing five copies of the WD40 motif, controls cell cycle function, sulfur metabolism, and methionine biosynthesis as part of the ubiquitin ligase complex; interacts with and regulates Met4p, localizes within the nucleus"	1	0	0	0	0.238095238	0	1	0.125
2985_OG5_130795_7 - FUNGI_YMR214W	YMR214W	"SCJ1 - One of several homologs of bacterial chaperone DnaJ, located in the ER lumen where it cooperates with Kar2p to mediate maturation of proteins"	1	0	0	0	0.19047619	0	1	0.3125
2986_OG5_134428_7 - FUNGI_YHR132W-A	YHR132W-A	IGO2 - Protein required for initiation of G0 program; prevents degradation of nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway; phosphorylated by Rim15p; GFP protein localizes to the cytoplasm and nucleus; similar to Igo1p	1	0	0	0	0.19047619	0	1	0.0625
2987_OG5_134428_7 - FUNGI_YNL157W	YNL157W	IGO1 - Protein required for initiation of G0 program; prevents degradation of nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway; phosphorylated by Rim15p; GFP protein localizes to the cytoplasm and nucleus; similar to Igo2p	1	0	0	0	0.19047619	0	1	0.0625
2988_OG5_130377_7 - FUNGI_YBL011W	YBL011W	"SCT1 - Glycerol 3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase of the glycerolipid biosynthesis pathway, prefers 16-carbon fatty acids, similar to Gpt2p, gene is constitutively transcribed"	1	0	0	0	0.142857143	0	1	0.625
2989_OG5_133758_7 - FUNGI_YMR055C	YMR055C	"BUB2 - Mitotic exit network regulator, forms GTPase-activating Bfa1p-Bub2p complex that binds Tem1p and spindle pole bodies, blocks cell cycle progression before anaphase in response to spindle and kinetochore damage"	1	0	0	0	0.142857143	0	1	0.125
2990_OG5_134823_7 - FUNGI_YNR032W	YNR032W	"PPG1 - Putative serine/threonine protein phosphatase of the type 2A-like phosphatase family, required for glycogen accumulation; interacts with Tap42p, which binds to and regulates other protein phosphatases"	1	0	0	0	0.142857143	0	1	0
2991_OG5_135020_7 - FUNGI_YBR260C	YBR260C	"RGD1 - GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organization"	1	0	0	0	0	0.142857143	1	0
2992_OG5_135346_7 - FUNGI_YKL089W	YKL089W	"MIF2 - Kinetochore protein with homology to human CENP-C, required for structural integrity of the spindle during anaphase spindle elongation, interacts with histones H2A, H2B, and H4, phosphorylated by Ipl1p"	1	0	0	0	0.142857143	0	1	0
2993_OG5_135420_7 - FUNGI_YOR017W	YOR017W	"PET127 - Protein with a role in 5'-end processing of mitochondrial RNAs, located in the mitochondrial membrane"	1	0	0	0	0.142857143	0	1	0
2994_OG5_135596_7 - FUNGI_YOL129W	YOL129W	VPS68 - Vacuolar membrane protein of unknown function involved in vacuolar protein sorting; also detected in the mitochondria	1	0	0	0	0	0.142857143	1	0
2995_OG5_135666_7 - FUNGI_YDR168W	YDR168W	CDC37 - Essential Hsp90p co-chaperone; necessary for passage through the START phase of the cell cycle; stabilizes protein kinase nascent chains and participates along with Hsp90p in their folding	1	0	0	0	0	0.142857143	1	0
2996_OG5_135765_7 - FUNGI_YJR144W	YJR144W	"MGM101 - Protein involved in mitochondrial genome maintenance; component of the mitochondrial nucleoid, required for the repair of oxidative mtDNA damage"	1	0	0	0	0.142857143	0	1	0
2997_OG5_129261_7 - FUNGI_YNL192W	YNL192W	"CHS1 - Chitin synthase I, requires activation from zymogenic form in order to catalyze the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for repairing the chitin septum during cytokinesis; transcription activated by mating factor"	1	0	0	0	0.095238095	0	1	0.0625
2998_OG5_129261_7 - FUNGI_YBR038W	YBR038W	CHS2 - Chitin synthase II; catalyzes transfer of N-acetylglucosamine (GlcNAc) to chitin upon activation of zymogenic form; required for chitin synthesis in the primary septum during cytokinesis; localization regulated by Cdk1p during mitosis	1	0	0	0	0.095238095	0	1	0.0625
2999_OG5_132456_7 - FUNGI_YHR202W	YHR202W	"YHR202W - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole, while HA-tagged protein is found in the soluble fraction, suggesting cytoplasmic localization"	1	0	0	0	0.095238095	0	1	0.0625
3000_OG5_133547_7 - FUNGI_YGR125W	YGR125W	YGR125W - Putative protein of unknown function; deletion mutant has decreased rapamycin resistance but normal wormannin resistance; green fluorescent protein (GFP)-fusion protein localizes to the vacuole	1	0	0	0	0.095238095	0	1	0.3125
3001_OG5_134225_7 - FUNGI_YDL010W	YDL010W	GRX6 - Cis-golgi localized monothiol glutaredoxin that binds an iron-sulfur cluster; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; functional overlap with GRX7	1	0	0	0	0.095238095	0	1	0.0625
3002_OG5_134225_7 - FUNGI_YBR014C	YBR014C	GRX7 - Cis-golgi localized monothiol glutaredoxin; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; does not bind metal ions; functional overlap with GRX6	1	0	0	0	0.095238095	0	1	0.0625
3003_OG5_134519_7 - FUNGI_YGR157W	YGR157W	"CHO2 - Phosphatidylethanolamine methyltransferase (PEMT), catalyzes the first step in the conversion of phosphatidylethanolamine to phosphatidylcholine during the methylation pathway of phosphatidylcholine biosynthesis"	1	0	0	0	0.095238095	0	1	0.0625
3004_OG5_135111_7 - FUNGI_YMR302C	YMR302C	YME2 - Integral inner mitochondrial membrane protein with a role in maintaining mitochondrial nucleoid structure and number; mutants exhibit an increased rate of mitochondrial DNA escape; shows some sequence similarity to exonucleases	1	0	0	0	0.095238095	0	1	0
3005_OG5_135269_7 - FUNGI_YDL146W	YDL146W	"LDB17 - Protein involved in the regulation of endocytosis; transiently recruited to actin cortical patches in a SLA1-dependent manner after late coat component assembly; GFP-fusion protein localizes to the periphery, cytoplasm, bud, and bud neck"	1	0	0	0	0.095238095	0	1	0
3006_OG5_135393_7 - FUNGI_YLR393W	YLR393W	"ATP10 - Mitochondrial inner membrane protein required for assembly of the F0 sector of mitochondrial F1F0 ATP synthase, interacts genetically with ATP6"	1	0	0	0	0.095238095	0	1	0.0625
3007_OG5_135407_7 - FUNGI_YDL056W	YDL056W	"MBP1 - Transcription factor involved in regulation of cell cycle progression from G1 to S phase, forms a complex with Swi6p that binds to MluI cell cycle box regulatory element in promoters of DNA synthesis genes"	1	0	0	0	0.095238095	0	1	0
3008_OG5_135566_7 - FUNGI_YMR247C	YMR247C	"RKR1 - RING domain E3 ubiquitin ligase; involved in the ubiquitin-mediated degradation of non-stop proteins; functional connections to chromatin modification; nuclear protein that also co-localizes with ribosomes; homolog of mouse Listerin, whose mutation has been reported to cause neurodegeneration in mice"	1	0	0	0	0.095238095	0	1	0
3009_OG5_135748_7 - FUNGI_YKR065C	YKR065C	PAM17 - Constituent of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); proposed alternatively to be a component of the import motor (PAM complex) or to interact with and modulate the core TIM23 complex	1	0	0	0	0.095238095	0	1	0
3010_OG5_135773_7 - FUNGI_YIR034C	YIR034C	"LYS1 - Saccharopine dehydrogenase (NAD+, L-lysine-forming), catalyzes the conversion of saccharopine to L-lysine, which is the final step in the lysine biosynthesis pathway; also has mRNA binding activity"	1	0	0	0	0.095238095	0	1	0
3011_OG5_134440_7 - FUNGI_YHL003C	YHL003C	"LAG1 - Ceramide synthase component, involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p"	1	0	0	0	0	0.071428571	1	0
3012_OG5_134440_7 - FUNGI_YKL008C	YKL008C	"LAC1 - Ceramide synthase component, involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lag1p"	1	0	0	0	0	0.071428571	1	0
3013_OG5_135936_7 - FUNGI_YCR077C	YCR077C	"PAT1 - Topoisomerase II-associated deadenylation-dependent mRNA-decapping factor; also required for faithful chromosome transmission, maintenance of rDNA locus stability, and protection of mRNA 3'-UTRs from trimming; functionally linked to Pab1p"	1	0	0	0	0	0.071428571	1	0
3014_OG5_136041_7 - FUNGI_YBR200W	YBR200W	"BEM1 - Protein containing SH3-domains, involved in establishing cell polarity and morphogenesis; functions as a scaffold protein for complexes that include Cdc24p, Ste5p, Ste20p, and Rsr1p"	1	0	0	0	0	0.071428571	1	0
3015_OG5_136116_7 - FUNGI_YIL115C	YIL115C	"NUP159 - Nucleoporin, subunit of the nuclear pore complex that is found exclusively on the cytoplasmic side, member of the Nup82 subcomplex, required for mRNA export"	1	0	0	0	0	0.071428571	1	0
3016_OG5_136161_7 - FUNGI_YDR407C	YDR407C	TRS120 - One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic	1	0	0	0	0	0.071428571	1	0
3017_OG5_136165_7 - FUNGI_YCL034W	YCL034W	"LSB5 - Protein of unknown function; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; may mediate disassembly of the Pan1 complex from the endocytic coat"	1	0	0	0	0	0.071428571	1	0
3018_OG5_136171_7 - FUNGI_YBL007C	YBL007C	SLA1 - Cytoskeletal protein binding protein required for assembly of the cortical actin cytoskeleton; interacts with proteins regulating actin dynamics and proteins required for endocytosis; found in the nucleus and cell cortex; has 3 SH3 domains	1	0	0	0	0	0.071428571	1	0
3019_OG5_129703_7 - FUNGI_YER119C	YER119C	AVT6 - Vacuolar aspartate and glutamate exporter; member of a family of seven genes (AVT1-7) related to vesicular GABA-glycine transporters; involved in compartmentalizing acidic amino acids in response to nitrogen starvation	1	0	0	0	0.047619048	0	1	0.4375
3020_OG5_129703_7 - FUNGI_YBL089W	YBL089W	"AVT5 - Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters"	1	0	0	0	0.047619048	0	1	0.4375
3021_OG5_129703_7 - FUNGI_YIL088C	YIL088C	"AVT7 - Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters"	1	0	0	0	0.047619048	0	1	0.4375
3022_OG5_132353_7 - FUNGI_YDL225W	YDL225W	"SHS1 - One of five related septins (Cdc3p, Cdc10p, Cdc11p, Cdc12p, Shs1p) that form a cortical filamentous collar at the mother-bud neck which is necessary for normal morphogenesis and cytokinesis"	1	0	0	0	0.047619048	0	1	0.125
3023_OG5_132353_7 - FUNGI_YJR076C	YJR076C	"CDC11 - Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM"	1	0	0	0	0.047619048	0	1	0.125
3024_OG5_132460_7 - FUNGI_YIR004W	YIR004W	"DJP1 - Cytosolic J-domain-containing protein, required for peroxisomal protein import and involved in peroxisome assembly, homologous to E. coli DnaJ"	1	0	0	0	0.047619048	0	1	0.375
3025_OG5_132495_7 - FUNGI_YDL198C	YDL198C	"GGC1 - Mitochondrial GTP/GDP transporter, essential for mitochondrial genome maintenance; has a role in mitochondrial iron transport; member of the mitochondrial carrier family"	1	0	0	0	0.047619048	0	1	0.25
3026_OG5_134945_7 - FUNGI_YOR134W	YOR134W	"BAG7 - Rho GTPase activating protein (RhoGAP), stimulates the intrinsic GTPase activity of Rho1p, which plays a role in actin cytoskeleton organization and control of cell wall synthesis; structurally and functionally related to Sac7p"	1	0	0	0	0.047619048	0	1	0
3027_OG5_134945_7 - FUNGI_YDR389W	YDR389W	"SAC7 - GTPase activating protein (GAP) for Rho1p, involved in signaling to the actin cytoskeleton, null mutations suppress tor2 mutations and temperature sensitive mutations in actin; potential Cdc28p substrate"	1	0	0	0	0.047619048	0	1	0
3028_OG5_135115_7 - FUNGI_YIL099W	YIL099W	"SGA1 - Intracellular sporulation-specific glucoamylase involved in glycogen degradation; induced during starvation of a/a diploids late in sporulation, but dispensable for sporulation"	1	0	0	0	0.047619048	0	1	0
3029_OG5_135272_7 - FUNGI_YFR030W	YFR030W	"MET10 - Subunit alpha of assimilatory sulfite reductase, which converts sulfite into sulfide"	1	0	0	0	0.047619048	0	1	0.0625
3030_OG5_135399_7 - FUNGI_YLR452C	YLR452C	"SST2 - GTPase-activating protein for Gpa1p, regulates desensitization to alpha factor pheromone; also required to prevent receptor-independent signaling of the mating pathway; member of the RGS (regulator of G-protein signaling) family"	1	0	0	0	0.047619048	0	1	0
3031_OG5_135400_7 - FUNGI_YFL033C	YFL033C	"RIM15 - Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; substrate of Pho80p-Pho85p kinase"	1	0	0	0	0.047619048	0	1	0
3032_OG5_135411_7 - FUNGI_YDL235C	YDL235C	"YPD1 - Phosphorelay intermediate protein, phosphorylated by the plasma membrane sensor Sln1p in response to osmotic stress and then in turn phosphorylates the response regulators Ssk1p in the cytosol and Skn7p in the nucleus"	1	0	0	0	0.047619048	0	1	0
3033_OG5_135414_7 - FUNGI_YCR008W	YCR008W	SAT4 - Ser/Thr protein kinase involved in salt tolerance; funtions in regulation of Trk1p-Trk2p potassium transporter; partially redundant with Hal5p; has similarity to Npr1p	1	0	0	0	0.047619048	0	1	0
3034_OG5_135421_7 - FUNGI_YML034W	YML034W	SRC1 - Inner nuclear membrane protein; functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; alternative splicing of SRC1 pre-mRNA is promoted by Hub1p; mutant has aneuploidy tolerance	1	0	0	0	0.047619048	0	1	0
3035_OG5_135421_7 - FUNGI_YDR458C	YDR458C	"HEH2 - Inner nuclear membrane (INM) protein; contains helix-extension-helix (HEH) motif, nuclear localization signal sequence; targeting to the INM requires the Srp1p-Kap95p karyopherins and the Ran cycle"	1	0	0	0	0.047619048	0	1	0
3036_OG5_135579_7 - FUNGI_YNL167C	YNL167C	SKO1 - Basic leucine zipper transcription factor of the ATF/CREB family; forms a complex with Tup1p and Cyc8p to both activate and repress transcription; cytosolic and nuclear protein involved in osmotic and oxidative stress responses	1	0	0	0	0.047619048	0	1	0
3037_OG5_135592_7 - FUNGI_YGR186W	YGR186W	TFG1 - TFIIF (Transcription Factor II) largest subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP74	1	0	0	0	0.047619048	0	1	0.0625
3038_OG5_135599_7 - FUNGI_YML104C	YML104C	"MDM1 - Intermediate filament protein, required for nuclear and mitochondrial transmission to daughter buds; contains a Phox homology (PX) domain and specifically binds phosphatidylinositol 3-phosphate (PtdIns-3-P)"	1	0	0	0	0.047619048	0	1	0.0625
3039_OG5_135633_7 - FUNGI_YBL106C	YBL106C	SRO77 - Protein with roles in exocytosis and cation homeostasis; functions in docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Sro7p and Drosophila lethal giant larvae tumor suppressor; interacts with SNARE protein Sec9p	1	0	0	0	0.047619048	0	1	0
3040_OG5_135633_7 - FUNGI_YPR032W	YPR032W	"SRO7 - Effector of Rab GTPase Sec4p, forms a complex with Sec4p and t-SNARE Sec9p; involved in exocytosis and docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Sro77p and Drosophila lgl tumor suppressor"	1	0	0	0	0.047619048	0	1	0
3041_OG5_135651_7 - FUNGI_YKR021W	YKR021W	ALY1 - Alpha arrestin that controls nutrient-mediated intracellular sorting of permease Gap1p; interacts with AP-1 subunit Apl4p; may regulate endocytosis of plasma membrane proteins by recruiting ubiquitin ligase Rsp5p to plasma membrane targets	1	0	0	0	0.047619048	0	1	0
3042_OG5_135651_7 - FUNGI_YJL084C	YJL084C	ALY2 - Alpha arrestin that controls nutrient-mediated intracellular sorting of permease Gap1p; interacts with AP-1 subunit Apl4p; phosphorylated by Npr1p and also by cyclin-CDK complex Pcl7p-Pho85p; promotes endocytosis of plasma membrane proteins	1	0	0	0	0.047619048	0	1	0
3043_OG5_135751_7 - FUNGI_YOR359W	YOR359W	"VTS1 - Post-transcriptional gene regulator, flap-structured DNA-binding and RNA-binding protein; shows genetic interactions with Vti1p, a v-SNARE involved in cis-Golgi membrane traffic; stimulates Dna2p endonuclease activity; contains a SAM domain"	1	0	0	0	0.047619048	0	1	0
3044_OG5_135753_7 - FUNGI_YHR199C	YHR199C	"AIM46 - Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss"	1	0	0	0	0.047619048	0	1	0
3045_OG5_135753_7 - FUNGI_YHR198C	YHR198C	"AIM18 - Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss"	1	0	0	0	0.047619048	0	1	0
3046_OG5_135758_7 - FUNGI_YOL009C	YOL009C	"MDM12 - Mitochondrial outer membrane protein, required for transmission of mitochondria to daughter cells; component of the ERMES complex that links the ER to mitochondria; may influence import and assembly of outer membrane beta-barrel proteins"	1	0	0	0	0.047619048	0	1	0.0625
3047_OG5_135764_7 - FUNGI_YGL066W	YGL066W	SGF73 - SAGA complex subunit with a role in anchoring the deubiquitination module into SAGA and SLIK complexes; involved in preinitiation complex assembly at promoters; human ortholog ataxin-7 is associated with spinocerebellar ataxia diseases	1	0	0	0	0.047619048	0	1	0
3048_OG5_135779_7 - FUNGI_YBL051C	YBL051C	"PIN4 - Protein involved in G2/M phase progression and response to DNA damage, interacts with Rad53p; contains an RNA recognition motif, a nuclear localization signal, and several SQ/TQ cluster domains; hyperphosphorylated in response to DNA damage"	1	0	0	0	0.047619048	0	1	0
3049_OG5_135788_7 - FUNGI_YJR101W	YJR101W	RSM26 - Mitochondrial ribosomal protein of the small subunit	1	0	0	0	0.047619048	0	1	0
3050_OG5_135925_7 - FUNGI_YDL240W	YDL240W	"LRG1 - Putative GTPase-activating protein (GAP) involved in the Pkc1p-mediated signaling pathway that controls cell wall integrity; appears to specifically regulate 1,3-beta-glucan synthesis"	1	0	0	0	0.047619048	0	1	0
3051_OG5_135974_7 - FUNGI_YAL014C	YAL014C	SYN8 - Endosomal SNARE related to mammalian syntaxin 8	1	0	0	0	0.047619048	0	1	0
3052_OG5_136049_7 - FUNGI_YMR100W	YMR100W	MUB1 - MYND domain-containing protein required for ubiquitination and turnover of Rpn4p; interacts with Ubr2p (E3) and indirectly with Rad6p (E2); short-lived protein degraded in a Ubr2p/Rad6p dependent manner; similar to the A. nidulans samB gene	1	0	0	0	0.047619048	0	1	0
3053_OG5_136085_7 - FUNGI_YKL064W	YKL064W	"MNR2 - Vacuolar membrane protein required for magnesium homeostasis; putative magnesium transporter; has similarity to Alr1p and Alr2p, which mediate influx of Mg2+ and other divalent cations"	1	0	0	0	0.047619048	0	1	0
3054_OG5_136098_7 - FUNGI_YBR007C	YBR007C	DSF2 - Deletion suppressor of mpt5 mutation	1	0	0	0	0.047619048	0	1	0
3055_OG5_136104_7 - FUNGI_YIL090W	YIL090W	ICE2 - Integral ER membrane protein with type-III transmembrane domains; mutations cause defects in cortical ER morphology in both the mother and daughter cells	1	0	0	0	0.047619048	0	1	0
3056_OG5_136112_7 - FUNGI_YML007W	YML007W	YAP1 - Basic leucine zipper (bZIP) transcription factor required for oxidative stress tolerance; activated by H2O2 through the multistep formation of disulfide bonds and transit from the cytoplasm to the nucleus; mediates resistance to cadmium	1	0	0	0	0.047619048	0	1	0
3057_OG5_136117_7 - FUNGI_YPL184C	YPL184C	"MRN1 - RNA-binding protein proposed to be involved in translational regulation; binds specific categories of mRNAs, including those that contain upstream open reading frames (uORFs) and internal ribosome entry sites (IRES)"	1	0	0	0	0.047619048	0	1	0
3058_OG5_136139_7 - FUNGI_YPR089W	YPR089W	YPR089W - Protein of unknown function; exhibits genetic interaction with ERG11 and protein-protein interaction with Hsp82p	1	0	0	0	0.047619048	0	1	0
3059_OG5_136148_7 - FUNGI_YPL228W	YPL228W	"CET1 - Beta (RNA 5'-triphosphatase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CEG1, a guanylyltransferase) involved in adding the 5' cap to mRNA; the mammalian enzyme is a single bifunctional polypeptide"	1	0	0	0	0.047619048	0	1	0
3060_OG5_136149_7 - FUNGI_YGL219C	YGL219C	MDM34 - Mitochondrial component of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth	1	0	0	0	0.047619048	0	1	0
3061_OG5_136162_7 - FUNGI_YHR194W	YHR194W	"MDM31 - Mitochondrial inner membrane protein with similarity to Mdm32p, required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MDM10, MDM12, and MDM34"	1	0	0	0	0.047619048	0	1	0
3062_OG5_136166_7 - FUNGI_YOR124C	YOR124C	UBP2 - Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins; interacts with Rsp5p and is required for MVB sorting of membrane proteins; can cleave polyubiquitin and has isopeptidase activity	1	0	0	0	0.047619048	0	1	0
3063_OG5_136371_7 - FUNGI_YOR373W	YOR373W	"NUD1 - Component of the spindle pole body outer plaque, required for exit from mitosis"	1	0	0	0	0.047619048	0	1	0
3064_OG5_133114_7 - FUNGI_YLR090W	YLR090W	"XDJ1 - Putative chaperone, homolog of E. coli DnaJ, closely related to Ydj1p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"	1	0	0.027777778	0	0	0	1	0.1875
3065_OG5_136152_7 - FUNGI_YOR301W	YOR301W	RAX1 - Protein involved in bud site selection during bipolar budding; localization requires Rax2p; has similarity to members of the insulin-related peptide superfamily	1	0	0.027777778	0	0	0	1	0
3066_OG5_131650_7 - FUNGI_YPR156C	YPR156C	TPO3 - Polyamine transport protein specific for spermine; localizes to the plasma membrane; member of the major facilitator superfamily	1	0	0	0	0	0	1	0
3067_OG5_131650_7 - FUNGI_YGR138C	YGR138C	TPO2 - Polyamine transport protein specific for spermine; localizes to the plasma membrane; transcription of TPO2 is regulated by Haa1p; member of the major facilitator superfamily	1	0	0	0	0	0	1	0
3068_OG5_132642_7 - FUNGI_YLL032C	YLL032C	"YLL032C - Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene"	1	0	0	0	0	0	1	0.125
3069_OG5_132841_7 - FUNGI_YDR191W	YDR191W	"HST4 - Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst3p in silencing at telomeres, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism"	1	0	0	0	0	0	1	0
3070_OG5_132841_7 - FUNGI_YOR025W	YOR025W	"HST3 - Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst4p in telomeric silencing, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism"	1	0	0	0	0	0	1	0
3071_OG5_133778_7 - FUNGI_YNL183C	YNL183C	NPR1 - Protein kinase that stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation; phosphorylates Aly2p	1	0	0	0	0	0	1	0
3072_OG5_133778_7 - FUNGI_YOR267C	YOR267C	HRK1 - Protein kinase implicated in activation of the plasma membrane H(+)-ATPase Pma1p in response to glucose metabolism; plays a role in ion homeostasis	1	0	0	0	0	0	1	0
3073_OG5_134005_7 - FUNGI_YDR247W	YDR247W	"VHS1 - Cytoplasmic serine/threonine protein kinase; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; homolog of Sks1p"	1	0	0	0	0	0	1	0
3074_OG5_134005_7 - FUNGI_YPL026C	YPL026C	SKS1 - Putative serine/threonine protein kinase; involved in the adaptation to low concentrations of glucose independent of the SNF3 regulated pathway	1	0	0	0	0	0	1	0
3075_OG5_134257_7 - FUNGI_YNR018W	YNR018W	AIM38 - Putative protein of unknown function; non-tagged protein is detected in purified mitochondria; may interact with respiratory chain complex IV; null mutant is viable and displays reduced frequency of mitochondrial genome loss	1	0	0	0	0	0	1	0
3076_OG5_134264_7 - FUNGI_YPR117W	YPR117W	YPR117W - Putative protein of unknown function	1	0	0	0	0	0	1	0
3077_OG5_134264_7 - FUNGI_YLR454W	YLR454W	"FMP27 - Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"	1	0	0	0	0	0	1	0
3078_OG5_134468_7 - FUNGI_YPL265W	YPL265W	"DIP5 - Dicarboxylic amino acid permease, mediates high-affinity and high-capacity transport of L-glutamate and L-aspartate; also a transporter for Gln, Asn, Ser, Ala, and Gly"	1	0	0	0	0	0	1	0
3079_OG5_135120_7 - FUNGI_YDL113C	YDL113C	ATG20 - Sorting nexin family member required for the cytoplasm-to-vacuole targeting (Cvt) pathway and for endosomal sorting; has a Phox homology domain that binds phosphatidylinositol-3-phosphate; interacts with Snx4p; potential Cdc28p substrate	1	0	0	0	0	0	1	0
3080_OG5_135120_7 - FUNGI_YDR425W	YDR425W	"SNX41 - Sorting nexin, involved in the retrieval of late-Golgi SNAREs from the post-Golgi endosome to the trans-Golgi network; interacts with Snx4p"	1	0	0	0	0	0	1	0
3081_OG5_135132_7 - FUNGI_YLR425W	YLR425W	TUS1 - Guanine nucleotide exchange factor (GEF) that functions to modulate Rho1p activity as part of the cell integrity signaling pathway; multicopy suppressor of tor2 mutation and ypk1 ypk2 double mutation; potential Cdc28p substrate	1	0	0	0	0	0	1	0
3082_OG5_135133_7 - FUNGI_YKL178C	YKL178C	"STE3 - Receptor for a factor pheromone, couples to MAP kinase cascade to mediate pheromone response; transcribed in alpha cells and required for mating by alpha cells, ligand bound receptors endocytosed and recycled to the plasma membrane; GPCR"	1	0	0	0	0	0	1	0
3083_OG5_135285_7 - FUNGI_YGR136W	YGR136W	"LSB1 - Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization"	1	0	0	0	0	0	1	0
3084_OG5_135285_7 - FUNGI_YPR154W	YPR154W	PIN3 - Protein that induces appearance of [PIN+] prion when overproduced	1	0	0	0	0	0	1	0
3085_OG5_135398_7 - FUNGI_YJR091C	YJR091C	"JSN1 - Member of the Puf family of RNA-binding proteins, interacts with mRNAs encoding membrane-associated proteins; involved in localizing the Arp2/3 complex to mitochondria; overexpression causes increased sensitivity to benomyl"	1	0	0	0	0	0	1	0
3086_OG5_135398_7 - FUNGI_YPR042C	YPR042C	"PUF2 - Member of the PUF protein family, which is defined by the presence of Pumilio homology domains that confer RNA binding activity; preferentially binds mRNAs encoding membrane-associated proteins"	1	0	0	0	0	0	1	0
3087_OG5_135424_7 - FUNGI_YBR171W	YBR171W	"SEC66 - Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER"	1	0	0	0	0	0	1	0.125
3088_OG5_135755_7 - FUNGI_YAR014C	YAR014C	"BUD14 - Protein involved in bud-site selection, Bud14p-Glc7p complex is a cortical regulator of dynein; inhibitor of the actin assembly factor Bnr1p (formin); diploid mutants display a random budding pattern instead of the wild-type bipolar pattern"	1	0	0	0	0	0	1	0
3089_OG5_135759_7 - FUNGI_YOR233W	YOR233W	"KIN4 - Serine/threonine protein kinase that inhibits the mitotic exit network (MEN) when the spindle position checkpoint is activated; localized asymmetrically to mother cell cortex, spindle pole body and bud neck"	1	0	0	0	0	0	1	0
3090_OG5_135759_7 - FUNGI_YPL141C	YPL141C	FRK1 - Putative protein kinase; similar to Kin4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; interacts with rRNA transcription and ribosome biogenesis factors and the long chain fatty acyl-CoA synthetase Faa3	1	0	0	0	0	0	1	0
3091_OG5_135767_7 - FUNGI_YIL041W	YIL041W	"GVP36 - BAR domain-containing protein that localizes to both early and late Golgi vesicles; required for adaptation to varying nutrient concentrations, fluid-phase endocytosis, polarization of the actin cytoskeleton, and vacuole biogenesis"	1	0	0	0	0	0	1	0
3092_OG5_135776_7 - FUNGI_YER128W	YER128W	YER128W - Putative protein of unknown function	1	0	0	0	0	0	1	0.0625
3093_OG5_135780_7 - FUNGI_YHR107C	YHR107C	"CDC12 - Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM"	1	0	0	0	0	0	1	0
3094_OG5_135784_7 - FUNGI_YHR115C	YHR115C	"DMA1 - Protein involved in ubiquitin ligation; plays a role in regulating spindle position and orientation; functionally redundant with Dma2p; orthologous to human RNF8 protein, also has sequence similarity to human Chfr."	1	0	0	0	0	0	1	0
3095_OG5_135784_7 - FUNGI_YNL116W	YNL116W	"DMA2 - Protein involved in ubiquitination; plays a role in regulating spindle position and orientation; functionally redundant with Dma1p; orthologous to human RNF8 protein, also has sequence similarity to human Chfr"	1	0	0	0	0	0	1	0
3096_OG5_135793_7 - FUNGI_YFL047W	YFL047W	RGD2 - GTPase-activating protein (RhoGAP) for Cdc42p and Rho5p	1	0	0	0	0	0	1	0
3097_OG5_135798_7 - FUNGI_YDR028C	YDR028C	"REG1 - Regulatory subunit of type 1 protein phosphatase Glc7p, involved in negative regulation of glucose-repressible genes"	1	0	0	0	0	0	1	0
3098_OG5_136010_7 - FUNGI_YMR171C	YMR171C	EAR1 - Specificity factor required for Rsp5p-dependent ubiquitination and sorting of specific cargo proteins at the multivesicular body; mRNA is targeted to the bud via the mRNA transport system involving She2p	1	0	0	0	0	0	1	0
3099_OG5_136031_7 - FUNGI_YGL122C	YGL122C	NAB2 - Nuclear polyadenylated RNA-binding protein required for nuclear mRNA export and poly(A) tail length control; binds nuclear pore protein Mlp1p; autoregulates mRNA levels; related to human hnRNPs; nuclear localization sequence binds Kap104p	1	0	0	0	0	0	1	0
3100_OG5_136120_7 - FUNGI_YMR264W	YMR264W	CUE1 - Endoplasmic reticulum membrane protein that recruits the ubiquitin-conjugating enzyme Ubc7p to the ER where it functions in protein degradation; contains a CUE domain that binds ubiquitin to facilitate intramolecular monoubiquitination	1	0	0	0	0	0	1	0
3101_OG5_136121_7 - FUNGI_YJL071W	YJL071W	"ARG2 - Acetylglutamate synthase (glutamate N-acetyltransferase), mitochondrial enzyme that catalyzes the first step in the biosynthesis of the arginine precursor ornithine; forms a complex with Arg5,6p"	1	0	0	0	0	0	1	0
3102_OG5_136133_7 - FUNGI_YPR097W	YPR097W	"YPR097W - Protein that contains a Phox homology (PX) domain and binds phosphoinositides; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"	1	0	0	0	0	0	1	0.0625
3103_OG5_136134_7 - FUNGI_YNL090W	YNL090W	"RHO2 - Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, involved in the establishment of cell polarity and in microtubule assembly"	1	0	0	0	0	0	1	0
3104_OG5_136135_7 - FUNGI_YLR295C	YLR295C	"ATP14 - Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis"	1	0	0	0	0	0	1	0
3105_OG5_136137_7 - FUNGI_YPR049C	YPR049C	ATG11 - Adapter protein for pexophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; directs receptor-bound cargo to the phagophore assembly site (PAS) for packaging into vesicles; required for recruiting other proteins to the (PAS)	1	0	0	0	0	0	1	0
3106_OG5_136138_7 - FUNGI_YPL145C	YPL145C	"KES1 - Member of the oxysterol binding protein family, which includes seven yeast homologs; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex"	1	0	0	0	0	0	1	0
3107_OG5_136141_7 - FUNGI_YMR212C	YMR212C	EFR3 - Protein required for Stt4-containing phosphoinositide kinase patch assembly at the plasma membrane; exhibits synthetic lethal genetic interactions with PHO85; has sequence similarity to the Drosophila rolling blackout (RBO) gene	1	0	0	0	0	0	1	0
3108_OG5_136155_7 - FUNGI_YLR055C	YLR055C	"SPT8 - Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA, required for SAGA-mediated inhibition at some promoters"	1	0	0	0	0	0	1	0
3109_OG5_136159_7 - FUNGI_YLR330W	YLR330W	"CHS5 - Component of the exomer complex, which also contains Csh6p, Bch1p, Bch2p, and Bud7p and is involved in export of selected proteins, such as chitin synthase Chs3p, from the Golgi to the plasma membrane"	1	0	0	0	0	0	1	0
3110_OG5_136170_7 - FUNGI_YGL106W	YGL106W	"MLC1 - Essential light chain for Myo1p, light chain for Myo2p; stabilizes Myo2p by binding to the neck region; interacts with Myo1p, Iqg1p, and Myo2p to coordinate formation and contraction of the actomyosin ring with targeted membrane deposition"	1	0	0	0	0	0	1	0
3111_OG5_136374_7 - FUNGI_YJL204C	YJL204C	RCY1 - F-box protein involved in recycling plasma membrane proteins internalized by endocytosis; localized to sites of polarized growth	1	0	0	0	0	0	1	0
3112_OG5_136382_7 - FUNGI_YPL078C	YPL078C	"ATP4 - Subunit b of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; contributes to the oligomerization of the complex; phosphorylated"	1	0	0	0	0	0	1	0
3113_OG5_136392_7 - FUNGI_YJR033C	YJR033C	"RAV1 - Subunit of the RAVE complex (Rav1p, Rav2p, Skp1p), which promotes assembly of the V-ATPase holoenzyme; required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins; potential Cdc28p substrate"	1	0	0	0	0	0	1	0
3114_OG5_136407_7 - FUNGI_YGL129C	YGL129C	"RSM23 - Mitochondrial ribosomal protein of the small subunit, has similarity to mammalian apoptosis mediator proteins; null mutation prevents induction of apoptosis by overproduction of metacaspase Mca1p"	1	0	0	0	0	0	1	0
3115_OG5_136411_7 - FUNGI_YMR024W	YMR024W	MRPL3 - Mitochondrial ribosomal protein of the large subunit	1	0	0	0	0	0	1	0
3116_OG5_136423_7 - FUNGI_YNL273W	YNL273W	"TOF1 - Subunit of a replication-pausing checkpoint complex (Tof1p-Mrc1p-Csm3p) that acts at the stalled replication fork to promote sister chromatid cohesion after DNA damage, facilitating gap repair of damaged DNA; interacts with the MCM helicase"	1	0	0	0	0	0	1	0
3117_OG5_136448_7 - FUNGI_YKR082W	YKR082W	"NUP133 - Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC), localizes to both sides of the NPC, required to establish a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p"	1	0	0	0	0	0	1	0
3118_OG5_136470_7 - FUNGI_YDR041W	YDR041W	"RSM10 - Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S10 ribosomal protein; essential for viability, unlike most other mitoribosomal proteins"	1	0	0	0	0	0	1	0
3119_OG5_136472_7 - FUNGI_YNL137C	YNL137C	NAM9 - Mitochondrial ribosomal component of the small subunit	1	0	0	0	0	0	1	0
3120_OG5_136494_7 - FUNGI_YDL202W	YDL202W	MRPL11 - Mitochondrial ribosomal protein of the large subunit	1	0	0	0	0	0	1	0
3121_OG5_136510_7 - FUNGI_YJL123C	YJL123C	MTC1 - Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to COPI-coated vesicles (early Golgi); mtc1 is synthetically lethal with cdc13-1	1	0	0	0	0	0	1	0
3122_OG5_136513_7 - FUNGI_YMR091C	YMR091C	"NPL6 - Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Ldb7p, and Htl1p to form a module important for a broad range of RSC functions; involved in nuclear protein import and maintenance of proper telomere length"	1	0	0	0	0	0	1	0
3123_OG5_136514_7 - FUNGI_YJL006C	YJL006C	"CTK2 - Beta subunit of C-terminal domain kinase I (CTDK-I), which phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and ribosomal protein Rps2p to increase translational fidelity"	1	0	0	0	0	0	1	0
3124_OG5_136517_7 - FUNGI_YLR319C	YLR319C	"BUD6 - Actin- and formin-interacting protein, involved in actin cable nucleation and polarized cell growth; isolated as bipolar budding mutant; potential Cdc28p substrate"	1	0	0	0	0	0	1	0
3125_OG5_136518_7 - FUNGI_YOR211C	YOR211C	"MGM1 - Mitochondrial GTPase, present in complex with Ugo1p and Fzo1p; required for mt morphology and genome maintenance; exists as long and short form with different distributions; homolog of human OPA1 involved in autosomal dominant optic atrophy"	1	0	0	0	0	0	1	0
3126_OG5_136519_7 - FUNGI_YNR039C	YNR039C	"ZRG17 - Endoplasmic reticulum protein of unknown function, transcription is induced under conditions of zinc deficiency; mutant phenotype suggests a role in uptake of zinc"	1	0	0	0	0	0	1	0
3127_OG5_136520_7 - FUNGI_YKL052C	YKL052C	"ASK1 - Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; phosphorylated during the cell cycle by cyclin-dependent kinases"	1	0	0	0	0	0	1	0
3128_OG5_136526_7 - FUNGI_YPR020W	YPR020W	ATP20 - Subunit g of the mitochondrial F1F0 ATP synthase; reversibly phosphorylated on two residues; unphosphorylated form is required for dimerization of the ATP synthase complex	1	0	0	0	0	0	1	0
3129_OG5_136532_7 - FUNGI_YGL093W	YGL093W	SPC105 - Subunit of a kinetochore-microtubule binding complex with Kre28p that bridges centromeric heterochromatin and kinetochore MAPs and motors; required for sister chromatid bi-orientation and kinetochore binding of SAC components	1	0	0	0	0	0	1	0
3130_OG5_136536_7 - FUNGI_YKL116C	YKL116C	"PRR1 - Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor"	1	0	0	0	0	0	1	0
3131_OG5_136540_7 - FUNGI_YCL032W	YCL032W	"STE50 - Protein involved in mating response, invasive/filamentous growth, and osmotolerance, acts as an adaptor that links G protein-associated Cdc42p-Ste20p complex to the effector Ste11p to modulate signal transduction"	1	0	0	0	0	0	1	0
3132_OG5_136544_7 - FUNGI_YMR129W	YMR129W	POM152 - Nuclear pore membrane glycoprotein; may be involved in duplication of nuclear pores and nuclear pore complexes during S-phase;	1	0	0	0	0	0	1	0
3133_OG5_136556_7 - FUNGI_YIL157C	YIL157C	COA1 - Mitochondrial inner membrane protein required for assembly of the cytochrome c oxidase complex (complex IV); interacts with complex IV assembly factor Shy1p during the early stages of assembly	1	0	0	0	0	0	1	0
3134_OG5_136558_7 - FUNGI_YDL212W	YDL212W	"SHR3 - Endoplasmic reticulum packaging chaperone, required for incorporation of amino acid permeases into COPII coated vesicles for transport to the cell surface"	1	0	0	0	0	0	1	0
3135_OG5_136559_7 - FUNGI_YOR223W	YOR223W	YOR223W - Putative protein of unknown function	1	0	0	0	0	0	1	0
3136_OG5_136560_7 - FUNGI_YNL279W	YNL279W	PRM1 - Pheromone-regulated multispanning membrane protein involved in membrane fusion during mating; predicted to have 5 transmembrane segments and a coiled coil domain; localizes to the shmoo tip; regulated by Ste12p	1	0	0	0	0	0	1	0
3137_OG5_136561_7 - FUNGI_YJL054W	YJL054W	TIM54 - Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane	1	0	0	0	0	0	1	0
3138_OG5_136563_7 - FUNGI_YBR290W	YBR290W	"BSD2 - Heavy metal ion homeostasis protein, facilitates trafficking of Smf1p and Smf2p metal transporters to the vacuole where they are degraded, controls metal ion transport, prevents metal hyperaccumulation, functions in copper detoxification"	1	0	0	0	0	0	1	0
3139_OG5_136566_7 - FUNGI_YLR292C	YLR292C	"SEC72 - Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER"	1	0	0	0	0	0	1	0
3140_OG5_136567_7 - FUNGI_YLL002W	YLL002W	RTT109 - Histone acetyltransferase critical for cell survival in the presence of DNA damage during S phase; acetylates H3-K56 and H3-K9; involved in non-homologous end joining and in regulation of Ty1 transposition; interacts physically with Vps75p	1	0	0	0	0	0	1	0
3141_OG5_136568_7 - FUNGI_YKL014C	YKL014C	"URB1 - Nucleolar protein required for the normal accumulation of 25S and 5.8S rRNAs, associated with the 27SA2 pre-ribosomal particle; proposed to be involved in the biogenesis of the 60S ribosomal subunit"	1	0	0	0	0	0	1	0
3142_OG5_136570_7 - FUNGI_YDR346C	YDR346C	"SVF1 - Protein with a potential role in cell survival pathways, required for the diauxic growth shift; expression in mammalian cells increases survival under conditions inducing apoptosis; mutant has increased aneuploidy tolerance"	1	0	0	0	0	0	1	0
3143_OG5_136573_7 - FUNGI_YAL010C	YAL010C	"MDM10 - Subunit of both the ERMES complex that links the ER to mitochondria, and of the mitochondrial sorting and assembly machinery (SAM complex) that functions in import and assembly of outer membrane beta-barrel proteins"	1	0	0	0	0	0	1	0
3144_OG5_136576_7 - FUNGI_YLR283W	YLR283W	YLR283W - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR283W is not an essential gene	1	0	0	0	0	0	1	0
3145_OG5_136577_7 - FUNGI_YLR345W	YLR345W	"YLR345W - Similar to 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase enzymes responsible for the metabolism of fructoso-2,6-bisphosphate; mRNA expression is repressed by the Rfx1p-Tup1p-Ssn6p repressor complex; YLR345W is not an essential gene"	1	0	0	0	0	0	1	0
3146_OG5_136579_7 - FUNGI_YMR158W	YMR158W	MRPS8 - Mitochondrial ribosomal protein of the small subunit	1	0	0	0	0	0	1	0
3147_OG5_136580_7 - FUNGI_YML127W	YML127W	RSC9 - Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway	1	0	0	0	0	0	1	0
3148_OG5_136588_7 - FUNGI_YGR113W	YGR113W	"DAM1 - Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; Ipl1p target for regulating kinetochore-MT attachments"	1	0	0	0	0	0	1	0
3149_OG5_136589_7 - FUNGI_YCR061W	YCR061W	YCR061W - Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; induced by treatment with 8-methoxypsoralen and UVA irradiation	1	0	0	0	0	0	1	0
3150_OG5_136592_7 - FUNGI_YLR203C	YLR203C	MSS51 - Specific translational activator for the mitochondrial COX1 mRNA; loosely associated with the matrix face of the mitochondrial inner membrane; influences both COX1 mRNA translation and Cox1p assembly into cytochrome c oxidase	1	0	0	0	0	0	1	0
3151_OG5_136594_7 - FUNGI_YLR182W	YLR182W	"SWI6 - Transcription cofactor, forms complexes with Swi4p and Mbp1p to regulate transcription at the G1/S transition; involved in meiotic gene expression; cell wall stress induces phosphorylation by Mpk1p, which regulates Swi6p localization"	1	0	0	0	0	0	1	0
3152_OG5_136821_7 - FUNGI_YNL175C	YNL175C	NOP13 - Nucleolar protein found in preribosomal complexes; contains an RNA recognition motif (RRM)	1	0	0	0	0	0	1	0
3153_OG5_137021_7 - FUNGI_YLR084C	YLR084C	RAX2 - N-glycosylated protein involved in the maintenance of bud site selection during bipolar budding; localization requires Rax1p; RAX2 mRNA stability is regulated by Mpt5p	1	0	0	0	0	0	1	0
3154_OG5_131310_7 - FUNGI_YCR084C	YCR084C	"TUP1 - General repressor of transcription, forms complex with Cyc8p, involved in the establishment of repressive chromatin structure through interactions with histones H3 and H4, appears to enhance expression of some genes"	1	0	0	0.125	0.19047619	0	1	0.125
3155_OG5_133941_7 - FUNGI_YGL242C	YGL242C	YGL242C - Putative protein of unknown function; deletion mutant is viable	1	0	0	0.125	0.19047619	0	1	0.0625
3156_OG5_130284_7 - FUNGI_YDL215C	YDL215C	"GDH2 - NAD(+)-dependent glutamate dehydrogenase, degrades glutamate to ammonia and alpha-ketoglutarate; expression sensitive to nitrogen catabolite repression and intracellular ammonia levels"	1	0	0.027777778	0	0.19047619	0.071428571	1	0.5625
3157_OG5_134739_7 - FUNGI_YKR080W	YKR080W	"MTD1 - NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase, plays a catalytic role in oxidation of cytoplasmic one-carbon units; expression is regulated by Bas1p and Bas2p, repressed by adenine, and may be induced by inositol and choline"	1	0	0.027777778	0	0.142857143	0	1	0.0625
3158_OG5_131644_7 - FUNGI_YDR332W	YDR332W	IRC3 - Putative RNA helicase of the DEAH/D-box family; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion	1	0.0625	0.333333333	0	0.095238095	0	1	0.0625
3159_OG5_132400_7 - FUNGI_YGL012W	YGL012W	"ERG4 - C-24(28) sterol reductase, catalyzes the final step in ergosterol biosynthesis; mutants are viable, but lack ergosterol"	1	0	0.027777778	0.125	0.095238095	0	1	0.125
3160_OG5_131422_7 - FUNGI_YDL095W	YDL095W	"PMT1 - Protein O-mannosyltransferase, transfers mannose from dolichyl phosphate-D-mannose to protein Ser/Thr residues; 1 of 7 related proteins involved in O-glycosylation which is essential for cell wall rigidity; involved in ER quality control"	1	0	0	0.125	0.095238095	0	1	0.0625
3161_OG5_131422_7 - FUNGI_YDL093W	YDL093W	"PMT5 - Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt3p, can instead interact with Pmt2p in some conditions; target for new antifungals"	1	0	0	0.125	0.095238095	0	1	0.0625
3162_OG5_134802_7 - FUNGI_YMR075W	YMR075W	RCO1 - Essential subunit of the histone deacetylase Rpd3S complex; interacts with Eaf3p	1	0	0	0.125	0.095238095	0	1	0
3163_OG5_132595_7 - FUNGI_YFR025C	YFR025C	"HIS2 - Histidinolphosphatase, catalyzes the eighth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control"	1	0	0.138888889	0	0.095238095	0	1	0.0625
3164_OG5_133130_7 - FUNGI_YJL127C	YJL127C	"SPT10 - Putative histone acetylase with a role in transcriptional silencing, sequence-specific activator of histone genes, binds specifically and cooperatively to pairs of UAS elements in core histone promoters, functions at or near the TATA box"	1	0	0.083333333	0	0.095238095	0	1	0
3165_OG5_133872_7 - FUNGI_YDR388W	YDR388W	"RVS167 - Actin-associated protein, interacts with Rvs161p to regulate actin cytoskeleton, endocytosis, and viability following starvation or osmotic stress; homolog of mammalian amphiphysin"	1	0	0	0	0.095238095	0.071428571	1	0
3166_OG5_135258_7 - FUNGI_YPL115C	YPL115C	"BEM3 - Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly"	1	0	0	0	0.095238095	0.071428571	1	0
3167_OG5_135348_7 - FUNGI_YDR322W	YDR322W	MRPL35 - Mitochondrial ribosomal protein of the large subunit	1	0	0	0	0.095238095	0.071428571	1	0
3168_OG5_131769_7 - FUNGI_YJL108C	YJL108C	"PRM10 - Pheromone-regulated protein, proposed to be involved in mating; predicted to have 5 transmembrane segments; induced by treatment with 8-methoxypsoralen and UVA irradiation"	1	0	0.055555556	0.125	0.047619048	0	1	0
3169_OG5_134273_7 - FUNGI_YGR229C	YGR229C	SMI1 - Protein involved in the regulation of cell wall synthesis; proposed to be involved in coordinating cell cycle progression with cell wall integrity	1	0	0.027777778	0.125	0.047619048	0	1	0
3170_OG5_134788_7 - FUNGI_YGL085W	YGL085W	LCL3 - Putative protein of unknown function; mutant has long chronological lifespan; has homology to Staphylococcus aureus nuclease; GFP-fusion protein localizes to mitochondria; is induced in response to the DNA-damaging agent MMS	1	0	0	0.125	0.047619048	0	1	0.1875
3171_OG5_135125_7 - FUNGI_YPL138C	YPL138C	"SPP1 - Subunit of COMPASS (Set1C), a complex which methylates histone H3 on lysine 4 and is required in telomeric transcriptional silencing; interacts with Orc2p; PHD finger domain protein similar to human CGBP, an unmethylated CpG binding protein"	1	0	0	0.125	0.047619048	0	1	0.0625
3172_OG5_135234_7 - FUNGI_YBR094W	YBR094W	PBY1 - Putative tubulin tyrosine ligase associated with P-bodies	1	0	0	0.125	0.047619048	0	1	0.0625
3173_OG5_135335_7 - FUNGI_YCL010C	YCL010C	SGF29 - Probable subunit of SAGA histone acetyltransferase complex	1	0	0	0.125	0.047619048	0	1	0
3174_OG5_135404_7 - FUNGI_YBR081C	YBR081C	"SPT7 - Subunit of the SAGA transcriptional regulatory complex, involved in proper assembly of the complex; also present as a C-terminally truncated form in the SLIK/SALSA transcriptional regulatory complex"	1	0	0	0.125	0.047619048	0	1	0
3175_OG5_133266_7 - FUNGI_YIR035C	YIR035C	YIR035C - Putative cytoplasmic protein of unknown function	1	0	0.083333333	0	0.047619048	0.071428571	1	0
3176_OG5_133266_7 - FUNGI_YIR036C	YIR036C	IRC24 - Putative benzil reductase;(GFP)-fusion protein localizes to the cytoplasm and is induced by the DNA-damaging agent MMS; sequence similarity with short-chain dehydrogenase/reductases; null mutant has increased spontaneous Rad52p foci	1	0	0.083333333	0	0.047619048	0.071428571	1	0
3177_OG5_135114_7 - FUNGI_YGL248W	YGL248W	"PDE1 - Low-affinity cyclic AMP phosphodiesterase, controls glucose and intracellular acidification-induced cAMP signaling, target of the cAMP-protein kinase A (PKA) pathway; glucose induces transcription and inhibits translation"	1	0	0.055555556	0	0.047619048	0	1	0
3178_OG5_134512_7 - FUNGI_YBL095W	YBL095W	"YBL095W - Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"	1	0	0.027777778	0	0.047619048	0	1	0
3179_OG5_134809_7 - FUNGI_YLL058W	YLL058W	"YLL058W - Putative protein of unknown function with similarity to Str2p, which is a cystathionine gamma-synthase important in sulfur metabolism; YLL058W is not an essential gene"	1	0	0.027777778	0	0.047619048	0	1	0.0625
3180_OG5_134809_7 - FUNGI_YML082W	YML082W	YML082W - Putative protein predicted to have carbon-sulfur lyase activity; transcriptionally regulated by Upc2p via an upstream sterol response element; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and the cytoplasm; YML082W is not an essential gene	1	0	0.027777778	0	0.047619048	0	1	0.0625
3181_OG5_134809_7 - FUNGI_YJR130C	YJR130C	"STR2 - Cystathionine gamma-synthase, converts cysteine into cystathionine"	1	0	0.027777778	0	0.047619048	0	1	0.0625
3182_OG5_134703_7 - FUNGI_YPL023C	YPL023C	MET12 - Protein with methylenetetrahydrofolate reductase (MTHFR) activity in vitro; null mutant has no phenotype and is prototrophic for methionine; MET13 encodes major isozyme of MTHFR	1	0.0625	0.111111111	0	0	0	1	0
3183_OG5_133658_7 - FUNGI_YLR138W	YLR138W	NHA1 - Na+/H+ antiporter involved in sodium and potassium efflux through the plasma membrane; required for alkali cation tolerance at acidic pH	1	0	0.055555556	0.125	0	0.071428571	1	0.125
3184_OG5_135782_7 - FUNGI_YOR132W	YOR132W	VPS17 - Subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde protein transport; peripheral membrane protein that assembles onto the membrane with Vps5p to promote vesicle formation	1	0	0	0.125	0	0.071428571	1	0
3185_OG5_134808_7 - FUNGI_YNL010W	YNL010W	YNL010W - Putative protein of unknown function with similarity to phosphoserine phosphatases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; homozygous diploid mutant shows an increase in glycogen accumulation	1	0	0.055555556	0.125	0	0	1	0
3186_OG5_135659_7 - FUNGI_YJL049W	YJL049W	YJL049W - Putative protein of unknown function; YJL049W is a non-essential gene	1	0	0.027777778	0.125	0	0	1	0
3187_OG5_134938_7 - FUNGI_YNL181W	YNL181W	YNL181W - Putative oxidoreductase; required for cell viability	1	0	0	0.125	0	0	1	0
3188_OG5_135253_7 - FUNGI_YIR006C	YIR006C	"PAN1 - Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p, associates with actin patches on the cell cortex; promotes protein-protein interactions essential for endocytosis; previously thought to be a subunit of poly(A) ribonuclease"	1	0	0	0.125	0	0	1	0
3189_OG5_135261_7 - FUNGI_YPL054W	YPL054W	LEE1 - Zinc-finger protein of unknown function	1	0	0	0.125	0	0	1	0.0625
3190_OG5_136105_7 - FUNGI_YJL087C	YJL087C	"TRL1 - tRNA ligase, required for tRNA splicing and for both splicing and translation of HAC1 mRNA in the UPR; has phosphodiesterase, polynucleotide kinase, and ligase activities; localized at the inner nuclear envelope and partially to polysomes"	1	0	0	0.125	0	0	1	0
3191_OG5_136146_7 - FUNGI_YDR359C	YDR359C	"EAF1 - Component of the NuA4 histone acetyltransferase complex; acts as a platform for assembly of NuA4 subunits into the native complex; required for initiation of pre-meiotic DNA replication, likely due to its requirement for expression of IME1"	1	0	0	0.125	0	0	1	0
3192_OG5_133771_7 - FUNGI_YKL004W	YKL004W	"AUR1 - Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase), required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance"	1	0.0625	0.083333333	0	0.142857143	0	1	0
3193_OG5_129123_7 - FUNGI_YKL182W	YKL182W	"FAS1 - Beta subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities"	1	0.0625	0.111111111	0	0.047619048	0	1	0.0625
3194_OG5_129123_7 - FUNGI_YPL231W	YPL231W	"FAS2 - Alpha subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains the acyl-carrier protein domain and beta-ketoacyl reductase, beta-ketoacyl synthase and self-pantetheinylation activities"	1	0.0625	0.111111111	0	0.047619048	0	1	0.0625
3195_OG5_133724_7 - FUNGI_YML016C	YML016C	"PPZ1 - Serine/threonine protein phosphatase Z, isoform of Ppz2p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance"	1	0.0625	0	0	0.047619048	0	1	0.0625
3196_OG5_133724_7 - FUNGI_YDR436W	YDR436W	"PPZ2 - Serine/threonine protein phosphatase Z, isoform of Ppz1p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance"	1	0.0625	0	0	0.047619048	0	1	0.0625
3197_OG5_135004_7 - FUNGI_YFL021W	YFL021W	GAT1 - Transcriptional activator of genes involved in nitrogen catabolite repression; contains a GATA-1-type zinc finger DNA-binding motif; activity and localization regulated by nitrogen limitation and Ure2p	1	0	0	0.125	0.047619048	0.071428571	0.95	0
3198_OG5_130469_7 - FUNGI_YOL137W	YOL137W	BSC6 - Protein of unknown function containing 8 putative transmembrane seqments; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression	1	0	0.194444444	0	0	0	0.95	0
3199_OG5_130801_7 - FUNGI_YOR378W	YOR378W	"YOR378W - Putative paralog of ATR1, but not required for boron tolerance; member of the DHA2 family of drug:H+ antiporters; YOR378W is not an essential gene"	1	0	0.138888889	0	0	0	0.95	0
3200_OG5_130801_7 - FUNGI_YML116W	YML116W	"ATR1 - Multidrug efflux pump of the major facilitator superfamily, required for resistance to aminotriazole and 4-nitroquinoline-N-oxide"	1	0	0.138888889	0	0	0	0.95	0
3201_OG5_130801_7 - FUNGI_YMR279C	YMR279C	YMR279C - Putative boron transporter involved in boron efflux and resistance; overexpression mutant but not null mutant displays boron tolerance phenotype; identified as a heat-induced gene in a high-throughout screen; YMR279C is not an essential gene; paralog of the efflux pump ATR1	1	0	0.138888889	0	0	0	0.95	0
3202_OG5_134996_7 - FUNGI_YGL203C	YGL203C	KEX1 - Protease involved in the processing of killer toxin and alpha factor precursor; cleaves Lys and Arg residues from the C-terminus of peptides and proteins	1	0	0	0	0.095238095	0	0.95	0.0625
3203_OG5_135680_7 - FUNGI_YIR033W	YIR033W	"MGA2 - ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Spt23p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting"	1	0	0	0	0.095238095	0	0.95	0
3204_OG5_135680_7 - FUNGI_YKL020C	YKL020C	"SPT23 - ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Mga2p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting"	1	0	0	0	0.095238095	0	0.95	0
3205_OG5_135935_7 - FUNGI_YCR076C	YCR076C	YCR076C - Putative protein of unknown function; YCR076C is not an essential gene	1	0	0	0	0.095238095	0	0.95	0
3206_OG5_136200_7 - FUNGI_YPR155C	YPR155C	NCA2 - Protein involved in regulation of mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p) of the Fo-F1 ATP synthase; functions with Nca3p	1	0	0	0	0.095238095	0	0.95	0
3207_OG5_133615_7 - FUNGI_YFL010C	YFL010C	"WWM1 - WW domain containing protein of unknown function; binds to Mca1p, a caspase-related protease that regulates H2O2-induced apoptosis; overexpression causes G1 phase growth arrest and clonal death that is suppressed by overexpression of MCA1"	1	0	0	0	0	0.071428571	0.95	0.0625
3208_OG5_136069_7 - FUNGI_YPL188W	YPL188W	"POS5 - Mitochondrial NADH kinase, phosphorylates NADH; also phosphorylates NAD(+) with lower specificity; required for the response to oxidative stress"	1	0	0.055555556	0	0	0	0.95	0
3209_OG5_132166_7 - FUNGI_YBR205W	YBR205W	"KTR3 - Putative alpha-1,2-mannosyltransferase involved in O- and N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; Svp26p mediates uptake of Ktr3p into COPII vesicles"	1	0	0	0	0.047619048	0	0.95	0.125
3210_OG5_132166_7 - FUNGI_YDR483W	YDR483W	"KRE2 - Alpha1,2-mannosyltransferase of the Golgi involved in protein mannosylation"	1	0	0	0	0.047619048	0	0.95	0.125
3211_OG5_132166_7 - FUNGI_YOR099W	YOR099W	"KTR1 - Alpha-1,2-mannosyltransferase involved in O- and N-linked protein glycosylation; type II membrane protein; member of the KRE2/MNT1 mannosyltransferase family"	1	0	0	0	0.047619048	0	0.95	0.125
3212_OG5_132515_7 - FUNGI_YBR023C	YBR023C	"CHS3 - Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan"	1	0	0	0	0.047619048	0	0.95	0.125
3213_OG5_133344_7 - FUNGI_YNL085W	YNL085W	"MKT1 - Protein that forms a complex with Pbp1p that may mediate posttranscriptional regulation of HO; involved in propagation of M2 dsRNA satellite of L-A virus; allelic variation affects mitochondrial genome stability, drug resistance, and more"	1	0	0	0	0.047619048	0	0.95	0.3125
3214_OG5_133761_7 - FUNGI_YDL124W	YDL124W	"YDL124W - NADPH-dependent alpha-keto amide reductase; reduces aromatic alpha-keto amides, aliphatic alpha-keto esters, and aromatic alpha-keto esters; member of the aldo-keto reductase (AKR) family"	1	0	0	0	0.047619048	0	0.95	0
3215_OG5_135267_7 - FUNGI_YDR173C	YDR173C	"ARG82 - Inositol polyphosphate multikinase (IPMK), sequentially phosphorylates Ins(1,4,5)P3 to form Ins(1,3,4,5,6)P5; also has diphosphoinositol polyphosphate synthase activity; regulates arginine-, phosphate-, and nitrogen-responsive genes"	1	0	0	0	0.047619048	0	0.95	0
3216_OG5_135416_7 - FUNGI_YDR090C	YDR090C	YDR090C - Putative protein of unknown function	1	0	0	0	0.047619048	0	0.95	0
3217_OG5_135649_7 - FUNGI_YFR022W	YFR022W	ROG3 - Protein that binds the ubiquitin ligase Rsp5p via its 2 PY motifs; has similarity to Rod1p; mutation suppresses the temperature sensitivity of an mck1 rim11 double mutant; proposed to regulate the endocytosis of plasma membrane proteins	1	0	0	0	0.047619048	0	0.95	0
3218_OG5_135649_7 - FUNGI_YOR018W	YOR018W	"ROD1 - Membrane protein that binds the ubiquitin ligase Rsp5p via its 2 PY motifs; overexpression confers resistance to the GST substrate o-dinitrobenzene,zinc, and calcium; proposed to regulate the endocytosis of plasma membrane proteins"	1	0	0	0	0.047619048	0	0.95	0
3219_OG5_135752_7 - FUNGI_YLR187W	YLR187W	"SKG3 - Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; potential Cdc28p substrate; similar to Caf120p and Skg4p"	1	0	0	0	0.047619048	0	0.95	0
3220_OG5_135752_7 - FUNGI_YNL278W	YNL278W	"CAF120 - Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation"	1	0	0	0	0.047619048	0	0.95	0
3221_OG5_135781_7 - FUNGI_YHR084W	YHR084W	"STE12 - Transcription factor that is activated by a MAP kinase signaling cascade, activates genes involved in mating or pseudohyphal/invasive growth pathways; cooperates with Tec1p transcription factor to regulate genes specific for invasive growth"	1	0	0	0	0.047619048	0	0.95	0.0625
3222_OG5_136088_7 - FUNGI_YBR281C	YBR281C	DUG2 - Probable di- and tri-peptidase; forms a complex with Dug1p and Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p)	1	0	0	0	0.047619048	0	0.95	0
3223_OG5_136099_7 - FUNGI_YOR129C	YOR129C	"AFI1 - Arf3p polarization-specific docking factor, required for the polarized distribution of the ADP-ribosylation factor, Arf3p; participates in polarity development and maintenance of a normal haploid budding pattern; interacts with Cnm7p"	1	0	0	0	0.047619048	0	0.95	0.0625
3224_OG5_136130_7 - FUNGI_YML128C	YML128C	"MSC1 - Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria and is phosphorylated"	1	0	0	0	0.047619048	0	0.95	0
3225_OG5_136160_7 - FUNGI_YLL006W	YLL006W	"MMM1 - ER integral membrane protein, component of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth"	1	0	0	0	0.047619048	0	0.95	0
3226_OG5_136164_7 - FUNGI_YIL105C	YIL105C	"SLM1 - Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm2p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex"	1	0	0	0	0.047619048	0	0.95	0
3227_OG5_136164_7 - FUNGI_YNL047C	YNL047C	"SLM2 - Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm1p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex"	1	0	0	0	0.047619048	0	0.95	0
3228_OG5_136319_7 - FUNGI_YMR185W	YMR185W	"YMR185W - Putative protein of unknown function; conflicting evidence on whether null mutant is viable with elongated buds, or inviable"	1	0	0	0	0.047619048	0	0.95	0
3229_OG5_136368_7 - FUNGI_YGR009C	YGR009C	SEC9 - t-SNARE protein important for fusion of secretory vesicles with the plasma membrane; similar to but not functionally redundant with Spo20p; SNAP-25 homolog	1	0	0	0	0.047619048	0	0.95	0
3230_OG5_136435_7 - FUNGI_YJL020C	YJL020C	BBC1 - Protein possibly involved in assembly of actin patches; interacts with an actin assembly factor Las17p and with the SH3 domains of Type I myosins Myo3p and Myo5p; localized predominantly to cortical actin patches	1	0	0	0	0.047619048	0	0.95	0
3231_OG5_136490_7 - FUNGI_YMR286W	YMR286W	MRPL33 - Mitochondrial ribosomal protein of the large subunit	1	0	0	0	0.047619048	0	0.95	0
3232_OG5_136549_7 - FUNGI_YHL027W	YHL027W	RIM101 - Transcriptional repressor involved in response to pH and in cell wall construction; required for alkaline pH-stimulated haploid invasive growth and sporulation; activated by proteolytic processing; similar to A. nidulans PacC	1	0	0	0	0.047619048	0	0.95	0
3233_OG5_136574_7 - FUNGI_YDL122W	YDL122W	UBP1 - Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins; cleaves at the C terminus of ubiquitin fusions irrespective of their size; capable of cleaving polyubiquitin chains	1	0	0	0	0.047619048	0	0.95	0
3234_OG5_136957_7 - FUNGI_YOR042W	YOR042W	"CUE5 - Protein containing a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern"	1	0	0	0	0.047619048	0	0.95	0
3235_OG5_130973_7 - FUNGI_YLL028W	YLL028W	"TPO1 - Polyamine transporter that recognizes spermine, putrescine, and spermidine; catalyzes uptake of polyamines at alkaline pH and excretion at acidic pH; phosphorylation enhances activity and sorting to the plasma membrane"	1	0	0.027777778	0	0	0	0.95	0
3236_OG5_132562_7 - FUNGI_YIL120W	YIL120W	"QDR1 - Multidrug transporter of the major facilitator superfamily, required for resistance to quinidine, ketoconazole, fluconazole, and barban"	1	0	0.027777778	0	0	0	0.95	0
3237_OG5_132562_7 - FUNGI_YIL121W	YIL121W	"QDR2 - Multidrug transporter of the major facilitator superfamily, required for resistance to quinidine, barban, cisplatin, and bleomycin; may have a role in potassium uptake"	1	0	0.027777778	0	0	0	0.95	0
3238_OG5_132562_7 - FUNGI_YNL065W	YNL065W	"AQR1 - Plasma membrane multidrug transporter of the major facilitator superfamily, confers resistance to short-chain monocarboxylic acids and quinidine; involved in the excretion of excess amino acids"	1	0	0.027777778	0	0	0	0.95	0
3239_OG5_130971_7 - FUNGI_YHL040C	YHL040C	"ARN1 - Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to ferrirubin, ferrirhodin, and related siderophores"	1	0	0	0	0	0	0.95	0
3240_OG5_130971_7 - FUNGI_YHL047C	YHL047C	"ARN2 - Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to the siderophore triacetylfusarinine C"	1	0	0	0	0	0	0.95	0
3241_OG5_130971_7 - FUNGI_YKR106W	YKR106W	GEX2 - Proton:glutathione antiporter localized to the vacuolar and plasma membranes; expressed at a very low level; almost identical to paralog Gex1p; potential role in resistance to oxidative stress and modulation of the PKA pathway	1	0	0	0	0	0	0.95	0
3242_OG5_130971_7 - FUNGI_YEL065W	YEL065W	"SIT1 - Ferrioxamine B transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; transcription is induced during iron deprivation and diauxic shift; potentially phosphorylated by Cdc28p"	1	0	0	0	0	0	0.95	0
3243_OG5_130971_7 - FUNGI_YCL073C	YCL073C	GEX1 - Proton:glutathione antiporter localized to the vacuolar and plasma membranes; imports glutathione from the vacuole and exports it through the plasma membrane; has a role in resistance to oxidative stress and modulation of the PKA pathway	1	0	0	0	0	0	0.95	0
3244_OG5_132038_7 - FUNGI_YOR049C	YOR049C	RSB1 - Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane	1	0	0	0	0	0	0.95	0
3245_OG5_134001_7 - FUNGI_YHR150W	YHR150W	"PEX28 - Peroxisomal integral membrane peroxin, involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p"	1	0	0	0	0	0	0.95	0
3246_OG5_134001_7 - FUNGI_YDR479C	YDR479C	"PEX29 - Peroxisomal integral membrane peroxin, involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p"	1	0	0	0	0	0	0.95	0
3247_OG5_134819_7 - FUNGI_YIL067C	YIL067C	YIL067C - Uncharacterized protein of unknown function	1	0	0	0	0	0	0.95	0
3248_OG5_135118_7 - FUNGI_YCR068W	YCR068W	ATG15 - Lipase required for intravacuolar lysis of autophagic bodies and Cvt bodies; targeted to intravacuolar vesicles during autophagy via the multivesicular body (MVB) pathway	1	0	0	0	0	0	0.95	0.125
3249_OG5_135124_7 - FUNGI_YIR007W	YIR007W	YIR007W - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YIR007W is a non-essential gene	1	0	0	0	0	0	0.95	0.0625
3250_OG5_135268_7 - FUNGI_YEL007W	YEL007W	YEL007W - Putative protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1)	1	0	0	0	0	0	0.95	0.0625
3251_OG5_135268_7 - FUNGI_YHR177W	YHR177W	YHR177W - Putative protein of unknown function; overexpression causes a cell cycle delay or arrest	1	0	0	0	0	0	0.95	0.0625
3252_OG5_135534_7 - FUNGI_YDR200C	YDR200C	VPS64 - Protein required for cytoplasm to vacuole targeting of proteins; forms a complex with Far3p and Far7p to Far11p involved in recovery from pheromone-induced cell cycle arrest; mutant has increased aneuploidy tolerance	1	0	0	0	0	0	0.95	0
3253_OG5_135534_7 - FUNGI_YLR238W	YLR238W	"FAR10 - Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far8p, Far9p, and Far11p; potential Cdc28p substrate"	1	0	0	0	0	0	0.95	0
3254_OG5_135756_7 - FUNGI_YHR142W	YHR142W	"CHS7 - Protein of unknown function, involved in chitin biosynthesis by regulating Chs3p export from the ER"	1	0	0	0	0	0	0.95	0.125
3255_OG5_135940_7 - FUNGI_YCR028C	YCR028C	FEN2 - Plasma membrane H+-pantothenate symporter; confers sensitivity to the antifungal agent fenpropimorph	1	0	0	0	0	0	0.95	0
3256_OG5_136107_7 - FUNGI_YLR403W	YLR403W	"SFP1 - Transcription factor that controls expression of ribosome biogenesis genes in response to nutrients and stress, regulates G2/M transitions during mitotic cell cycle and DNA-damage response, modulates cell size; regulated by TORC1 and Mrs6p"	1	0	0	0	0	0	0.95	0.0625
3257_OG5_136115_7 - FUNGI_YJR054W	YJR054W	YJR054W - Vacuolar protein of unknown function; potential Cdc28p substrate	1	0	0	0	0	0	0.95	0
3258_OG5_136122_7 - FUNGI_YPL133C	YPL133C	RDS2 - Transcription factor involved in regulating gluconeogenesis and glyoxylate cycle genes; member of the zinc cluster family of proteins; confers resistance to ketoconazole	1	0	0	0	0	0	0.95	0
3259_OG5_136123_7 - FUNGI_YNL215W	YNL215W	IES2 - Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions; essential for growth under anaerobic conditions	1	0	0	0	0	0	0.95	0
3260_OG5_136131_7 - FUNGI_YPR091C	YPR091C	"YPR091C - Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; GFP-fusion protein localizes to the ER; contains a PH domain and binds phosphatidylinositols and other lipids in a large-scale study"	1	0	0	0	0	0	0.95	0.0625
3261_OG5_136145_7 - FUNGI_YPL116W	YPL116W	"HOS3 - Trichostatin A-insensitive homodimeric histone deacetylase (HDAC) with specificity in vitro for histones H3, H4, H2A, and H2B; similar to Hda1p, Rpd3p, Hos1p, and Hos2p; deletion results in increased histone acetylation at rDNA repeats"	1	0	0	0	0	0	0.95	0
3262_OG5_136483_7 - FUNGI_YHR064C	YHR064C	SSZ1 - Hsp70 protein that interacts with Zuo1p (a DnaJ homolog) to form a ribosome-associated complex that binds the ribosome via the Zuo1p subunit; also involved in pleiotropic drug resistance via sequential activation of PDR1 and PDR5; binds ATP	1	0	0	0	0	0	0.95	0
3263_OG5_136512_7 - FUNGI_YPL140C	YPL140C	"MKK2 - Mitogen-activated kinase kinase involved in protein kinase C signaling pathway that controls cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk1p"	1	0	0	0	0	0	0.95	0
3264_OG5_136512_7 - FUNGI_YOR231W	YOR231W	"MKK1 - Mitogen-activated kinase kinase involved in protein kinase C signaling pathway that controls cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p"	1	0	0	0	0	0	0.95	0
3265_OG5_136530_7 - FUNGI_YDR201W	YDR201W	"SPC19 - Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; also localized to nuclear side of spindle pole body"	1	0	0	0	0	0	0.95	0
3266_OG5_136565_7 - FUNGI_YNL291C	YNL291C	"MID1 - N-glycosylated integral membrane protein of the ER membrane and plasma membrane, functions as a stretch-activated Ca2+-permeable cation channel required for Ca2+ influx stimulated by pheromone; interacts with Cch1p; forms an oligomer"	1	0	0	0	0	0	0.95	0.0625
3267_OG5_136578_7 - FUNGI_YKL051W	YKL051W	"SFK1 - Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane"	1	0	0	0	0	0	0.95	0
3268_OG5_136582_7 - FUNGI_YDR052C	YDR052C	"DBF4 - Regulatory subunit of Cdc7p-Dbf4p kinase complex, required for Cdc7p kinase activity and initiation of DNA replication; phosphorylates the Mcm2-7 family of proteins; cell cycle regulated"	1	0	0	0	0	0	0.95	0
3269_OG5_136593_7 - FUNGI_YLR324W	YLR324W	"PEX30 - Peroxisomal integral membrane protein, involved in negative regulation of peroxisome number; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p"	1	0	0	0	0	0	0.95	0
3270_OG5_136755_7 - FUNGI_YGL029W	YGL029W	CGR1 - Protein involved in nucleolar integrity and processing of the pre-rRNA for the 60S ribosome subunit; transcript is induced in response to cytotoxic stress but not genotoxic stress	1	0	0	0	0	0	0.95	0
3271_OG5_136802_7 - FUNGI_YFR041C	YFR041C	ERJ5 - Type I membrane protein with a J domain is required to preserve the folding capacity of the endoplasmic reticulum; loss of the non-essential ERJ5 gene leads to a constitutively induced unfolded protein response	1	0	0	0	0	0	0.95	0
3272_OG5_136809_7 - FUNGI_YAL041W	YAL041W	"CDC24 - Guanine nucleotide exchange factor (GEF or GDP-release factor) for Cdc42p; required for polarity establishment and maintenance, and mutants have morphological defects in bud formation and shmooing"	1	0	0	0	0	0	0.95	0
3273_OG5_136817_7 - FUNGI_YDR176W	YDR176W	"NGG1 - Transcriptional regulator involved in glucose repression of Gal4p-regulated genes; component of transcriptional adaptor and histone acetyltransferase complexes, the ADA complex, the SAGA complex, and the SLIK complex"	1	0	0	0	0	0	0.95	0
3274_OG5_136835_7 - FUNGI_YOR052C	YOR052C	"YOR052C - Nuclear protein of unknown function; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner and by weak acid; transcriptionally regulated by Rpn4p along with proteasome subunit genes; putative ortholog of human AIRAP, which stimulates proteasome activity in response to arsenic"	1	0	0	0	0	0	0.95	0
3275_OG5_136902_7 - FUNGI_YBR173C	YBR173C	UMP1 - Short-lived chaperone required for correct maturation of the 20S proteasome; may inhibit premature dimerization of proteasome half-mers; degraded by proteasome upon completion of its assembly	1	0	0	0	0	0	0.95	0
3276_OG5_136919_7 - FUNGI_YGL194C	YGL194C	"HOS2 - Histone deacetylase required for gene activation via specific deacetylation of lysines in H3 and H4 histone tails; subunit of the Set3 complex, a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity"	1	0	0	0	0	0	0.95	0
3277_OG5_136947_7 - FUNGI_YDL173W	YDL173W	PAR32 - Putative protein of unknown function; hyperphosphorylated upon rapamycin treatment in a Tap42p-dependent manner; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; PAR32 is not an essential gene	1	0	0	0	0	0	0.95	0
3278_OG5_136952_7 - FUNGI_YPL260W	YPL260W	YPL260W - Putative substrate of cAMP-dependent protein kinase (PKA); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YPL260W is not an essential gene	1	0	0	0	0	0	0.95	0
3279_OG5_136956_7 - FUNGI_YOR216C	YOR216C	RUD3 - Golgi matrix protein involved in the structural organization of the cis-Golgi; interacts genetically with COG3 and USO1	1	0	0	0	0	0	0.95	0
3280_OG5_136958_7 - FUNGI_YNL131W	YNL131W	TOM22 - Component of the TOM (translocase of outer mitochondrial membrane) complex responsible for initial import of mitochondrially directed proteins; acts as a receptor for precursor proteins and mediates interaction between TOM and TIM complexes	1	0	0	0	0	0	0.95	0
3281_OG5_136972_7 - FUNGI_YHR001W-A	YHR001W-A	"QCR10 - Subunit of the ubiqunol-cytochrome c oxidoreductase complex which includes Cobp, Rip1p, Cyt1p, Cor1p, Qcr2p, Qcr6p, Qcr7p, Qcr8p, Qcr9p, and Qcr10p and comprises part of the mitochondrial respiratory chain"	1	0	0	0	0	0	0.95	0
3282_OG5_136973_7 - FUNGI_YDR367W	YDR367W	KEI1 - Component of inositol phosphorylceramide (IPC) synthase; forms a complex with Aur1p and regulates its activity; required for IPC synthase complex localization to the Golgi; post-translationally processed by Kex2p; KEI1 is an essential gene	1	0	0	0	0	0	0.95	0
3283_OG5_136976_7 - FUNGI_YGL133W	YGL133W	"ITC1 - Subunit of the ATP-dependent Isw2p-Itc1p chromatin remodeling complex, required for repression of a-specific genes, repression of early meiotic genes during mitotic growth, and repression of INO1; similar to mammalian Acf1p, the regulatory subunit of the mammalian ATP-utilizing chromatin assembly and modifying factor (ACF) complex"	1	0	0	0	0	0	0.95	0
3284_OG5_136981_7 - FUNGI_YGR193C	YGR193C	"PDX1 - Dihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) of the mitochondrial pyruvate dehydrogenase (PDH) complex, plays a structural role in the complex by binding and positioning E3 to the dihydrolipoamide acetyltransferase (E2) core"	1	0	0	0	0	0	0.95	0
3285_OG5_136983_7 - FUNGI_YML050W	YML050W	AIM32 - Putative protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss	1	0	0	0	0	0	0.95	0
3286_OG5_136989_7 - FUNGI_YOR043W	YOR043W	"WHI2 - Protein required, with binding partner Psr1p, for full activation of the general stress response, possibly through Msn2p dephosphorylation; regulates growth during the diauxic shift; negative regulator of G1 cyclin expression"	1	0	0	0	0	0	0.95	0
3287_OG5_136990_7 - FUNGI_YIL093C	YIL093C	RSM25 - Mitochondrial ribosomal protein of the small subunit	1	0	0	0	0	0	0.95	0
3288_OG5_136991_7 - FUNGI_YCL047C	YCL047C	POF1 - Protein involved in the filamentation pathway; interacts physically with Kss1p and suppresses the filamentation defect of a kss1 deletion	1	0	0	0	0	0	0.95	0
3289_OG5_136996_7 - FUNGI_YDR175C	YDR175C	RSM24 - Mitochondrial ribosomal protein of the small subunit	1	0	0	0	0	0	0.95	0
3290_OG5_136998_7 - FUNGI_YCR033W	YCR033W	"SNT1 - Subunit of the Set3C deacetylase complex that interacts directly with the Set3C subunit, Sif2p; putative DNA-binding protein; mutant has increased aneuploidy tolerance"	1	0	0	0	0	0	0.95	0
3291_OG5_137000_7 - FUNGI_YDR470C	YDR470C	UGO1 - Outer membrane component of the mitochondrial fusion machinery; binds directly to Fzo1p and Mgm1p and thus links these two GTPases during mitochondrial fusion; facilitates dimerization of Fzo1p during fusion	1	0	0	0	0	0	0.95	0
3292_OG5_137001_7 - FUNGI_YLR104W	YLR104W	LCL2 - Putative protein of unknown function; mutant is deficient in amounts of cell wall mannosylphosphate and has long chronological lifespan; genetic interactions suggest a role in ER-associated protein degradation (ERAD)	1	0	0	0	0	0	0.95	0
3293_OG5_137005_7 - FUNGI_YDR320C	YDR320C	SWA2 - Auxilin-like protein involved in vesicular transport; clathrin-binding protein required for uncoating of clathrin-coated vesicles	1	0	0	0	0	0	0.95	0
3294_OG5_137010_7 - FUNGI_YFR011C	YFR011C	"AIM13 - Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria; null mutant displays reduced respiratory growth and reduced frequency of mitochondrial genome loss"	1	0	0	0	0	0	0.95	0
3295_OG5_137011_7 - FUNGI_YCL012C	YCL012C	"YCL012C - Putative protein of unknown function; orthologs are present in S. bayanus, S. paradoxus and Ashbya gossypii; YCL012C is not an essential gene"	1	0	0	0	0	0	0.95	0
3296_OG5_137013_7 - FUNGI_YLR023C	YLR023C	"IZH3 - Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity"	1	0	0	0	0	0	0.95	0
3297_OG5_137015_7 - FUNGI_YGR235C	YGR235C	"YGR235C - Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"	1	0	0	0	0	0	0.95	0
3298_OG5_137017_7 - FUNGI_YPL083C	YPL083C	"SEN54 - Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p"	1	0	0	0	0	0	0.95	0
3299_OG5_137022_7 - FUNGI_YLL023C	YLL023C	"POM33 - Transmembrane nucleoporin involved in nuclear pore complex (NPC) distribution, assembly or stabilization; highly conserved across species, orthologous to human TMEM33 and paralogous to Per33p"	1	0	0	0	0	0	0.95	0
3300_OG5_137024_7 - FUNGI_YMR140W	YMR140W	SIP5 - Protein of unknown function; interacts with both the Reg1p/Glc7p phosphatase and the Snf1p kinase	1	0	0	0	0	0	0.95	0
3301_OG5_137226_7 - FUNGI_YBR276C	YBR276C	"PPS1 - Protein phosphatase with specificity for serine, threonine, and tyrosine residues; has a role in the DNA synthesis phase of the cell cycle"	1	0	0	0	0	0	0.95	0
3302_OG5_137275_7 - FUNGI_YDR405W	YDR405W	MRP20 - Mitochondrial ribosomal protein of the large subunit	1	0	0	0	0	0	0.95	0
3303_OG5_135296_7 - FUNGI_YCR051W	YCR051W	YCR051W - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; contains ankyrin (Ank) repeats; YCR051W is not an essential gene	1	0	0	0.125	0.095238095	0	0.95	0.0625
3304_OG5_135412_7 - FUNGI_YHL039W	YHL039W	EFM1 - Probable lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	1	0	0	0.125	0.095238095	0	0.95	0
3305_OG5_134693_7 - FUNGI_YNL091W	YNL091W	"NST1 - Protein of unknown function, mediates sensitivity to salt stress; interacts physically with the splicing factor Msl1p and also displays genetic interaction with MSL1"	1	0	0.027777778	0	0.095238095	0	0.95	0.125
3306_OG5_135068_7 - FUNGI_YLR248W	YLR248W	RCK2 - Protein kinase involved in the response to oxidative and osmotic stress; identified as suppressor of S. pombe cell cycle checkpoint mutations; similar to CaM (calmodulin) kinases	1	0	0	0	0.095238095	0.142857143	0.95	0.0625
3307_OG5_134687_7 - FUNGI_YHR158C	YHR158C	"KEL1 - Protein required for proper cell fusion and cell morphology; functions in a complex with Kel2p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate"	1	0	0	0	0.095238095	0.071428571	0.95	0
3308_OG5_135290_7 - FUNGI_YNL052W	YNL052W	"COX5A - Subunit Va of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; predominantly expressed during aerobic growth while its isoform Vb (Cox5Bp) is expressed during anaerobic growth"	1	0	0	0	0.095238095	0.071428571	0.95	0
3309_OG5_135290_7 - FUNGI_YIL111W	YIL111W	"COX5B - Subunit Vb of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; predominantly expressed during anaerobic growth while its isoform Va (Cox5Ap) is expressed during aerobic growth"	1	0	0	0	0.095238095	0.071428571	0.95	0
3310_OG5_133333_7 - FUNGI_YOR021C	YOR021C	YOR021C - Putative protein of unknown function; YOR021C is not an essential gene; predicted to be involved in rRNA processing and ribosome biogenesis and in biopolymer catabolism	1	0.1875	0	0	0.047619048	0	0.95	0.1875
3311_OG5_134449_7 - FUNGI_YGR092W	YGR092W	DBF2 - Ser/Thr kinase involved in transcription and stress response; functions as part of a network of genes in exit from mitosis; localization is cell cycle regulated; activated by Cdc15p during the exit from mitosis	1	0	0	0.125	0.047619048	0	0.95	0
3312_OG5_134449_7 - FUNGI_YPR111W	YPR111W	"DBF20 - Ser/Thr kinase involved in late nuclear division, one of the mitotic exit network (MEN) proteins; necessary for the execution of cytokinesis"	1	0	0	0.125	0.047619048	0	0.95	0
3313_OG5_134772_7 - FUNGI_YLR309C	YLR309C	"IMH1 - Protein involved in vesicular transport, mediates transport between an endosomal compartment and the Golgi, contains a Golgi-localization (GRIP) domain that interacts with activated Arl1p-GTP to localize Imh1p to the Golgi"	1	0	0	0.125	0.047619048	0	0.95	0
3314_OG5_133339_7 - FUNGI_YDR415C	YDR415C	YDR415C - Putative protein of unknown function	1	0	0.111111111	0	0.047619048	0	0.95	0
3315_OG5_135675_7 - FUNGI_YMR218C	YMR218C	TRS130 - One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in ER to Golgi membrane traffic; mutation activates transcription of OCH1	1	0	0	0	0.047619048	0.071428571	0.95	0
3316_OG5_135966_7 - FUNGI_YBR179C	YBR179C	FZO1 - Mitofusin; integral membrane protein involved in mitochondrial outer membrane tethering and fusion; role in mitochondrial genome maintenance; efficient tethering and degradation of Fzo1p requires an intact N-terminal GTPase domain; targeted for destruction by the ubiquitin ligase SCF-Mdm30p and the cytosolic ubiquitin-proteasome system	1	0	0	0	0.047619048	0.071428571	0.95	0
3317_OG5_132160_7 - FUNGI_YER056C	YER056C	"FCY2 - Purine-cytosine permease, mediates purine (adenine, guanine, and hypoxanthine) and cytosine accumulation"	1	0.125	0.055555556	0	0	0	0.95	0.0625
3318_OG5_132160_7 - FUNGI_YER060W	YER060W	"FCY21 - Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function"	1	0.125	0.055555556	0	0	0	0.95	0.0625
3319_OG5_132160_7 - FUNGI_YER060W-A	YER060W-A	"FCY22 - Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function"	1	0.125	0.055555556	0	0	0	0.95	0.0625
3320_OG5_130470_7 - FUNGI_YNL134C	YNL134C	YNL134C - Putative protein of unknown function with similarity to dehydrogenases from other model organisms; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced by the DNA-damaging agent MMS	1	0	0	0.125	0	0.071428571	0.95	0
3321_OG5_130470_7 - FUNGI_YLR460C	YLR460C	"YLR460C - Member of the quinone oxidoreductase family, up-regulated in response to the fungicide mancozeb; possibly up-regulated by iodine"	1	0	0	0.125	0	0.071428571	0.95	0
3322_OG5_130470_7 - FUNGI_YCR102C	YCR102C	"YCR102C - Putative protein of unknown function, involved in copper metabolism; similar to C. carbonum toxD gene; member of the quinone oxidoreductase family"	1	0	0	0.125	0	0.071428571	0.95	0
3323_OG5_134501_7 - FUNGI_YDL086W	YDL086W	"YDL086W - Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL086W is not an essential gene"	1	0	0.138888889	0.125	0	0	0.95	0
3324_OG5_132941_7 - FUNGI_YOL065C	YOL065C	"INP54 - Phosphatidylinositol 4,5-bisphosphate 5-phosphatase with a role in secretion, localizes to the endoplasmic reticulum via the C-terminal tail; lacks the Sac1 domain and proline-rich region found in the other 3 INP proteins"	1	0	0	0.125	0	0	0.95	0.1875
3325_OG5_135769_7 - FUNGI_YEL001C	YEL001C	IRC22 - Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; YEL001C is non-essential; null mutant displays increased levels of spontaneous Rad52p foci	1	0	0	0.125	0	0	0.95	0
3326_OG5_135963_7 - FUNGI_YOR370C	YOR370C	"MRS6 - Rab escort protein, forms a complex with the Ras-like small GTPase Ypt1p that is required for the prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p); sequence similarity to mammalian choroideraemia gene"	1	0	0	0.125	0	0	0.95	0
3327_OG5_136136_7 - FUNGI_YJL095W	YJL095W	"BCK1 - Mitogen-activated protein (MAP) kinase kinase kinase acting in the protein kinase C signaling pathway, which controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p"	1	0	0	0.125	0	0	0.95	0
3328_OG5_136157_7 - FUNGI_YDL054C	YDL054C	"MCH1 - Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport"	1	0	0	0.125	0	0	0.95	0
3329_OG5_136525_7 - FUNGI_YCR079W	YCR079W	PTC6 - Mitochondrial type 2C protein phosphatase (PP2C) with similarity to mammalian PP1Ks; involved in mitophagy; null mutant is sensitive to rapamycin and has decreased phosphorylation of the Pda1 subunit of pyruvate dehydrogenase	1	0	0	0.125	0	0	0.95	0
3330_OG5_136626_7 - FUNGI_YKL138C	YKL138C	MRPL31 - Mitochondrial ribosomal protein of the large subunit	1	0	0	0.125	0	0	0.95	0
3331_OG5_133975_7 - FUNGI_YFL025C	YFL025C	"BST1 - GPI inositol deacylase of the ER that negatively regulates COPII vesicle formation, prevents production of vesicles with defective subunits, required for proper discrimination between resident ER proteins and Golgi-bound cargo molecules"	1	0	0	0.125	0.19047619	0	0.95	0.125
3332_OG5_132675_7 - FUNGI_YPL199C	YPL199C	"YPL199C - Putative protein of unknown function, predicted to be palmitoylated"	1	0	0	0	0.19047619	0	0.9	0.25
3333_OG5_136009_7 - FUNGI_YNL027W	YNL027W	CRZ1 - Transcription factor that activates transcription of genes involved in stress response; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation	1	0	0	0	0.095238095	0	0.9	0.0625
3334_OG5_136372_7 - FUNGI_YHR114W	YHR114W	"BZZ1 - SH3 domain protein implicated in the regulation of actin polymerization, able to recruit actin polymerization machinery through its SH3 domains, colocalizes with cortical actin patches and Las17p, interacts with type I myosins"	1	0	0	0	0	0.071428571	0.9	0
3335_OG5_136584_7 - FUNGI_YNL094W	YNL094W	"APP1 - Protein of unknown function, interacts with Rvs161p and Rvs167p; computational analysis of protein-protein interactions in large-scale studies suggests a possible role in actin filament organization"	1	0	0.055555556	0	0	0	0.9	0
3336_OG5_131896_7 - FUNGI_YJL057C	YJL057C	IKS1 - Putative serine/threonine kinase; expression is induced during mild heat stress; deletion mutants are hypersensitive to copper sulphate and resistant to sorbate; interacts with an N-terminal fragment of Sst2p	1	0	0	0	0.047619048	0	0.9	0.5625
3337_OG5_136312_7 - FUNGI_YCL061C	YCL061C	"MRC1 - S-phase checkpoint protein required for DNA replication; interacts with and stabilizes Pol2p at stalled replication forks during stress, where it forms a pausing complex with Tof1p and is phosphorylated by Mec1p; protects uncapped telomeres"	1	0	0	0	0.047619048	0	0.9	0
3338_OG5_136813_7 - FUNGI_YLR321C	YLR321C	SFH1 - Component of the RSC chromatin remodeling complex; essential gene required for cell cycle progression and maintenance of proper ploidy; phosphorylated in the G1 phase of the cell cycle; Snf5p paralog	1	0	0	0	0.047619048	0	0.9	0
3339_OG5_136870_7 - FUNGI_YBR098W	YBR098W	"MMS4 - Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in recombination, DNA repair, and joint molecule formation/resolution during meiotic recombination"	1	0	0	0	0.047619048	0	0.9	0
3340_OG5_131649_7 - FUNGI_YMR006C	YMR006C	PLB2 - Phospholipase B (lysophospholipase) involved in phospholipid metabolism; displays transacylase activity in vitro; overproduction confers resistance to lysophosphatidylcholine	1	0	0	0	0	0	0.9	0
3341_OG5_131649_7 - FUNGI_YOL011W	YOL011W	PLB3 - Phospholipase B (lysophospholipase) involved in phospholipid metabolism; hydrolyzes phosphatidylinositol and phosphatidylserine and displays transacylase activity in vitro	1	0	0	0	0	0	0.9	0
3342_OG5_131649_7 - FUNGI_YMR008C	YMR008C	"PLB1 - Phospholipase B (lysophospholipase) involved in lipid metabolism, required for deacylation of phosphatidylcholine and phosphatidylethanolamine but not phosphatidylinositol"	1	0	0	0	0	0	0.9	0
3343_OG5_134534_7 - FUNGI_YGR086C	YGR086C	"PIL1 - Primary component of eisosomes, which are large immobile cell cortex structures associated with endocytosis; null mutants show activation of Pkc1p/Ypk1p stress resistance pathways; detected in phosphorylated state in mitochondria"	1	0	0	0	0	0	0.9	0
3344_OG5_134534_7 - FUNGI_YPL004C	YPL004C	"LSP1 - Primary component of eisosomes, which are large immobile patch structures at the cell cortex associated with endocytosis, along with Pil1p and Sur7p; null mutants show activation of Pkc1p/Ypk1p stress resistance pathways"	1	0	0	0	0	0	0.9	0
3345_OG5_135116_7 - FUNGI_YML100W	YML100W	"TSL1 - Large subunit of trehalose 6-phosphate synthase (Tps1p)/phosphatase (Tps2p) complex, which converts uridine-5'-diphosphoglucose and glucose 6-phosphate to trehalose, similar to Tps3p and may share function; mutant has aneuploidy tolerance"	1	0	0	0	0	0	0.9	0
3346_OG5_135116_7 - FUNGI_YMR261C	YMR261C	"TPS3 - Regulatory subunit of trehalose-6-phosphate synthase/phosphatase complex, which synthesizes the storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway"	1	0	0	0	0	0	0.9	0
3347_OG5_135123_7 - FUNGI_YHR112C	YHR112C	YHR112C - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	1	0	0	0	0	0	0.9	0
3348_OG5_135770_7 - FUNGI_YMR063W	YMR063W	"RIM9 - Protein of unknown function, involved in the proteolytic activation of Rim101p in response to alkaline pH; has similarity to A. nidulans PalI; putative membrane protein"	1	0	0	0	0	0	0.9	0
3349_OG5_135772_7 - FUNGI_YER046W	YER046W	"SPO73 - Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensible for both nuclear divisions during meiosis"	1	0	0	0	0	0	0.9	0
3350_OG5_136103_7 - FUNGI_YOL048C	YOL048C	RRT8 - Putative protein of unknown function; identified in a screen for mutants with increased levels of rDNA transcription; green fluorescent protein (GFP)-fusion protein localizes to lipid particles	1	0	0	0	0	0	0.9	0.0625
3351_OG5_136522_7 - FUNGI_YCR030C	YCR030C	SYP1 - Protein of unknown function that is involved in endocytic site formation; may regulate assembly and disassembly of the septin ring; colocalizes and interacts with septin subunits; potential role in actin cytoskeletal organization	1	0	0	0	0	0	0.9	0
3352_OG5_136527_7 - FUNGI_YAL034W-A	YAL034W-A	MTW1 - Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; critical to kinetochore assembly	1	0	0	0	0	0	0.9	0.125
3353_OG5_136552_7 - FUNGI_YDR348C	YDR348C	YDR348C - Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and bud neck; potential Cdc28p substrate	1	0	0	0	0	0	0.9	0
3354_OG5_136552_7 - FUNGI_YHR097C	YHR097C	YHR097C - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus	1	0	0	0	0	0	0.9	0
3355_OG5_136557_7 - FUNGI_YBR132C	YBR132C	"AGP2 - High affinity polyamine permease, preferentially uses spermidine over putrescine; expression is down-regulated by osmotic stress; plasma membrane carnitine transporter, also functions as a low-affinity amino acid permease"	1	0	0	0	0	0	0.9	0
3356_OG5_136786_7 - FUNGI_YBR074W	YBR074W	YBR074W - Putative metalloprotease	1	0	0	0	0	0	0.9	0
3357_OG5_136876_7 - FUNGI_YLR455W	YLR455W	YLR455W - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)	1	0	0	0	0	0	0.9	0
3358_OG5_136903_7 - FUNGI_YGR233C	YGR233C	"PHO81 - Cyclin-dependent kinase (CDK) inhibitor, regulates Pho80p-Pho85p and Pcl7p-Pho85p cyclin-CDK complexes in response to phosphate levels; inhibitory activity for Pho80p-Pho85p requires myo-D-inositol heptakisphosphate (IP7) generated by Vip1p"	1	0	0	0	0	0	0.9	0
3359_OG5_136949_7 - FUNGI_YGL131C	YGL131C	SNT2 - DNA binding protein with similarity to the S. pombe Snt2 protein; computational analysis suggests a role in regulation of expression of genes encoding amine transporters	1	0	0	0	0	0	0.9	0
3360_OG5_136967_7 - FUNGI_YDL181W	YDL181W	INH1 - Protein that inhibits ATP hydrolysis by the F1F0-ATP synthase; inhibitory function is enhanced by stabilizing proteins Stf1p and Stf2p; has similarity to Stf1p; has a calmodulin-binding motif and binds calmodulin in vitro	1	0	0	0	0	0	0.9	0
3361_OG5_136967_7 - FUNGI_YDL130W-A	YDL130W-A	STF1 - Protein involved in regulation of the mitochondrial F1F0-ATP synthase; Stf1p and Stf2p may act as stabilizing factors that enhance inhibitory action of the Inh1p protein	1	0	0	0	0	0	0.9	0
3362_OG5_136969_7 - FUNGI_YBR239C	YBR239C	"ERT1 - Transcriptional regulator of nonfermentable carbon utilization; GFP-fusion protein localizes to cytoplasm, nucleus; null mutation affects periodicity of transcriptional and metabolic oscillation; plays role in restricting Ty1 transposition"	1	0	0	0	0	0	0.9	0
3363_OG5_136971_7 - FUNGI_YGL064C	YGL064C	"MRH4 - Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function"	1	0	0	0	0	0	0.9	0
3364_OG5_136979_7 - FUNGI_YIL118W	YIL118W	RHO3 - Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins involved in the establishment of cell polarity; GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p	1	0	0	0	0	0	0.9	0
3365_OG5_136985_7 - FUNGI_YMR182C	YMR182C	RGM1 - Putative transcriptional repressor with proline-rich zinc fingers; overproduction impairs cell growth	1	0	0	0	0	0	0.9	0
3366_OG5_136985_7 - FUNGI_YPL230W	YPL230W	"USV1 - Putative transcription factor containing a C2H2 zinc finger; mutation affects transcriptional regulation of genes involved in growth on non-fermentable carbon sources, response to salt stress and cell wall biosynthesis"	1	0	0	0	0	0	0.9	0
3367_OG5_136995_7 - FUNGI_YBR122C	YBR122C	MRPL36 - Mitochondrial ribosomal protein of the large subunit; overproduction suppresses mutations in the COX2 leader peptide-encoding region	1	0	0	0	0	0	0.9	0
3368_OG5_137008_7 - FUNGI_YML020W	YML020W	YML020W - Putative protein of unknown function	1	0	0	0	0	0	0.9	0.0625
3369_OG5_137225_7 - FUNGI_YJL178C	YJL178C	ATG27 - Type I membrane protein involved in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; may be involved in membrane delivery to the phagophore assembly site	1	0	0	0	0	0	0.9	0
3370_OG5_137274_7 - FUNGI_YJL166W	YJL166W	"QCR8 - Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p"	1	0	0	0	0	0	0.9	0
3371_OG5_137406_7 - FUNGI_YCR019W	YCR019W	MAK32 - Protein necessary for structural stability of L-A double-stranded RNA-containing particles	1	0	0	0	0	0	0.9	0
3372_OG5_137412_7 - FUNGI_YER002W	YER002W	"NOP16 - Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis"	1	0	0	0	0	0	0.9	0
3373_OG5_137416_7 - FUNGI_YDR377W	YDR377W	"ATP17 - Subunit f of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis"	1	0	0	0	0	0	0.9	0
3374_OG5_137429_7 - FUNGI_YKR085C	YKR085C	MRPL20 - Mitochondrial ribosomal protein of the large subunit	1	0	0	0	0	0	0.9	0
3375_OG5_137441_7 - FUNGI_YBR043C	YBR043C	"QDR3 - Multidrug transporter of the major facilitator superfamily, has a role in polyamine homeostasis; expression is upregulated under polyamine stress; required for resistance to quinidine, barban, cisplatin, and bleomycin"	1	0	0	0	0	0	0.9	0
3376_OG5_137445_7 - FUNGI_YHR067W	YHR067W	"HTD2 - Mitochondrial 3-hydroxyacyl-thioester dehydratase involved in fatty acid biosynthesis, required for respiratory growth and for normal mitochondrial morphology"	1	0	0	0	0	0	0.9	0
3377_OG5_137447_7 - FUNGI_YCL052C	YCL052C	"PBN1 - Essential component of glycosylphosphatidylinositol-mannosyltransferase I, required for the autocatalytic post-translational processing of the protease B precursor Prb1p, localizes to ER in lumenal orientation; homolog of mammalian PIG-X"	1	0	0	0	0	0	0.9	0
3378_OG5_137448_7 - FUNGI_YGL016W	YGL016W	"KAP122 - Karyopherin beta, responsible for import of the Toa1p-Toa2p complex into the nucleus; binds to nucleoporins Nup1p and Nup2p; may play a role in regulation of pleiotropic drug resistance"	1	0	0	0	0	0	0.9	0
3379_OG5_137451_7 - FUNGI_YLR250W	YLR250W	SSP120 - Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern	1	0	0	0	0	0	0.9	0
3380_OG5_137454_7 - FUNGI_YDR016C	YDR016C	"DAD1 - Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis"	1	0	0	0	0	0	0.9	0
3381_OG5_137458_7 - FUNGI_YNL206C	YNL206C	"RTT106 - Histone chaperone, involved in regulation of chromatin structure in both transcribed and silenced chromosomal regions; affects transcriptional elongation; has a role in regulation of Ty1 transposition"	1	0	0	0	0	0	0.9	0
3382_OG5_135593_7 - FUNGI_YPL181W	YPL181W	CTI6 - Protein that relieves transcriptional repression by binding to the Cyc8p-Tup1p corepressor and recruiting the SAGA complex to the repressed promoter; contains a PHD finger domain	1	0	0	0.125	0.095238095	0	0.9	0
3383_OG5_136002_7 - FUNGI_YNL108C	YNL108C	YNL108C - Putative protein of unknown function with similarity to Tfc7p and prokaryotic phosphotransfer enzymes; null mutant shows alterations in glucose metabolism; GFP-fusion protein localizes to the cytoplasm and nucleus	1	0	0	0.125	0.047619048	0	0.9	0
3384_OG5_136002_7 - FUNGI_YOR110W	YOR110W	TFC7 - One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA globular domain of TFIIIC that binds DNA at the BoxA promoter sites of tRNA and similar genes	1	0	0	0.125	0.047619048	0	0.9	0
3385_OG5_136154_7 - FUNGI_YER118C	YER118C	"SHO1 - Transmembrane osmosensor involved in activation of the Cdc42p- and MAP kinase-dependent filamentous growth pathway and the high-osmolarity glycerol response pathway; phosphorylated by Hog1p; interacts with Pbs2p, Msb2p, Hkr1p, and Ste11p"	1	0	0	0.125	0.047619048	0	0.9	0
3386_OG5_130665_7 - FUNGI_YOL119C	YOL119C	"MCH4 - Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport"	1	0	0	0.125	0	0.071428571	0.9	0
3387_OG5_130665_7 - FUNGI_YOR306C	YOR306C	"MCH5 - Plasma membrane riboflavin transporter; facilitates the uptake of vitamin B2; required for FAD-dependent processes; sequence similarity to mammalian monocarboxylate permeases, however mutants are not deficient in monocarboxylate transport"	1	0	0	0.125	0	0.071428571	0.9	0
3388_OG5_136100_7 - FUNGI_YDL179W	YDL179W	"PCL9 - Cyclin, forms a functional kinase complex with Pho85p cyclin-dependent kinase (Cdk), expressed in late M/early G1 phase, activated by Swi5p"	1	0	0.027777778	0	0	0.071428571	0.9	0
3389_OG5_136100_7 - FUNGI_YNL289W	YNL289W	"PCL1 - Cyclin, interacts with cyclin-dependent kinase Pho85p; member of the Pcl1,2-like subfamily, involved in the regulation of polarized growth and morphogenesis and progression through the cell cycle; localizes to sites of polarized cell growth"	1	0	0.027777778	0	0	0.071428571	0.9	0
3390_OG5_133659_7 - FUNGI_YBL061C	YBL061C	"SKT5 - Activator of Chs3p (chitin synthase III), recruits Chs3p to the bud neck via interaction with Bni4p; has similarity to Shc1p, which activates Chs3p during sporulation"	1	0	0.027777778	0.125	0.19047619	0	0.9	0.1875
3391_OG5_135048_7 - FUNGI_YDL106C	YDL106C	PHO2 - Homeobox transcription factor; regulatory targets include genes involved in phosphate metabolism; binds cooperatively with Pho4p to the PHO5 promoter; phosphorylation of Pho2p facilitates interaction with Pho4p	1	0	0	0	0.142857143	0.071428571	0.9	0.0625
3392_OG5_134096_7 - FUNGI_YGR055W	YGR055W	"MUP1 - High affinity methionine permease, integral membrane protein with 13 putative membrane-spanning regions; also involved in cysteine uptake"	1	0	0	0	0.142857143	0	0.85	0
3393_OG5_135763_7 - FUNGI_YMR123W	YMR123W	"PKR1 - V-ATPase assembly factor, functions with other V-ATPase assembly factors in the ER to efficiently assemble the V-ATPase membrane sector (V0)"	1	0	0	0	0.142857143	0	0.85	0.0625
3394_OG5_133994_7 - FUNGI_YDL144C	YDL144C	YDL144C - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YDL144C is not an essential gene.	1	0	0.111111111	0	0	0	0.85	0
3395_OG5_134530_7 - FUNGI_YDR100W	YDR100W	TVP15 - Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p	1	0	0	0	0.095238095	0	0.85	0.25
3396_OG5_136583_7 - FUNGI_YGL172W	YGL172W	"NUP49 - Subunit of the Nsp1p-Nup57p-Nup49p-Nic96p subcomplex of the nuclear pore complex (NPC), required for nuclear export of ribosomes"	1	0	0	0	0.095238095	0	0.85	0.0625
3397_OG5_136074_7 - FUNGI_YMR289W	YMR289W	"ABZ2 - Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase), catalyzes the third step in para-aminobenzoic acid biosynthesis; involved in folic acid biosynthesis"	1	0	0.083333333	0	0	0	0.85	0
3398_OG5_137232_7 - FUNGI_YDR006C	YDR006C	SOK1 - Protein whose overexpression suppresses the growth defect of mutants lacking protein kinase A activity; involved in cAMP-mediated signaling; localized to the nucleus; similar to the mouse testis-specific protein PBS13	1	0	0	0	0	0.071428571	0.85	0
3399_OG5_135768_7 - FUNGI_YGL035C	YGL035C	MIG1 - Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase	1	0	0	0	0.047619048	0	0.85	0
3400_OG5_136321_7 - FUNGI_YDR192C	YDR192C	"NUP42 - Subunit of the nuclear pore complex (NPC) that localizes exclusively to the cytoplasmic side; involved in RNA export, most likely at a terminal step; interacts with Gle1p"	1	0	0	0	0.047619048	0	0.85	0.125
3401_OG5_136551_7 - FUNGI_YOR087W	YOR087W	"YVC1 - Vacuolar cation channel, mediates release of Ca(2+) from the vacuole in response to hyperosmotic shock"	1	0	0	0	0.047619048	0	0.85	0
3402_OG5_136799_7 - FUNGI_YLR137W	YLR137W	RKM5 - Protein lysine methyltransferase; monomethylates Lys-46 of the ribosomal large subunit Rpl1a/Rpl1b; member of the seven beta-strand methyltransferase superfamily; orthologs only found among fungal species	1	0	0	0	0.047619048	0	0.85	0
3403_OG5_136951_7 - FUNGI_YBR214W	YBR214W	"SDS24 - One of two S. cerevisiae homologs (Sds23p and Sds24p) of the S. pombe Sds23 protein, which is implicated in APC/cyclosome regulation; involved in cell separation during budding; may play an indirect role in fluid-phase endocytosis"	1	0	0	0	0.047619048	0	0.85	0
3404_OG5_136951_7 - FUNGI_YGL056C	YGL056C	"SDS23 - One of two S. cerevisiae homologs (Sds23p and Sds24p) of the S. pombe Sds23 protein, which is implicated in APC/cyclosome regulation; involved in cell separation during budding"	1	0	0	0	0.047619048	0	0.85	0
3405_OG5_137414_7 - FUNGI_YER114C	YER114C	"BOI2 - Protein implicated in polar growth, functionally redundant with Boi1p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain"	1	0	0	0	0.047619048	0	0.85	0
3406_OG5_137422_7 - FUNGI_YLR087C	YLR087C	"CSF1 - Protein required for fermentation at low temperature; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"	1	0	0	0	0.047619048	0	0.85	0
3407_OG5_137433_7 - FUNGI_YLR077W	YLR077W	FMP25 - Mitochondrial inner membrane protein required for an early step in assembly of respiratory complex III (cytochrome bc1 complex); mRNA is targeted to mitochondria	1	0	0	0	0.047619048	0	0.85	0
3408_OG5_134004_7 - FUNGI_YDL237W	YDL237W	"AIM6 - Putative protein of unknown function, required for respiratory growth; YDL237W is not an essential gene"	1	0	0.027777778	0	0	0	0.85	0
3409_OG5_130254_7 - FUNGI_YLL051C	YLL051C	FRE6 - Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels	1	0	0	0	0	0	0.85	0
3410_OG5_130254_7 - FUNGI_YOR384W	YOR384W	"FRE5 - Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"	1	0	0	0	0	0	0.85	0
3411_OG5_130254_7 - FUNGI_YKL220C	YKL220C	"FRE2 - Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels"	1	0	0	0	0	0	0.85	0
3412_OG5_130254_7 - FUNGI_YNR060W	YNR060W	"FRE4 - Ferric reductase, reduces a specific subset of siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels"	1	0	0	0	0	0	0.85	0
3413_OG5_130254_7 - FUNGI_YOR381W	YOR381W	"FRE3 - Ferric reductase, reduces siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels"	1	0	0	0	0	0	0.85	0
3414_OG5_136144_7 - FUNGI_YGL247W	YGL247W	"BRR6 - Essential nuclear envelope integral membrane protein required for nuclear envelope morphology, nuclear pore complex localization, nuclear export; exhibits synthetic lethal genetic interactions with genes involved in lipid metabolism"	1	0	0	0	0	0	0.85	0.125
3415_OG5_136151_7 - FUNGI_YHR154W	YHR154W	RTT107 - Protein implicated in Mms22-dependent DNA repair during S phase; involved in recruiting the SMC5/6 complex to double-strand breaks; DNA damage induces phosphorylation by Mec1p at one or more SQ/TQ motifs; interacts with Mms22p and Slx4p; has four BRCT domains; has a role in regulation of Ty1 transposition	1	0	0	0	0	0	0.85	0.0625
3416_OG5_136550_7 - FUNGI_YJL206C	YJL206C	"YJL206C - Putative protein of unknown function; similar to transcriptional regulators from the Zn[2]-Cys[6] binuclear cluster protein family; mRNA is weakly cell cycle regulated, peaking in S phase; induced rapidly upon MMS treatment"	1	0	0	0	0	0	0.85	0
3417_OG5_136550_7 - FUNGI_YIL130W	YIL130W	"ASG1 - Zinc cluster protein proposed to function as a transcriptional regulator involved in the stress response; null mutants have a respiratory deficiency, calcofluor white sensitivity and slightly increased cycloheximide resistance"	1	0	0	0	0	0	0.85	0
3418_OG5_136620_7 - FUNGI_YIL156W-B	YIL156W-B	"YIL156W-B - Putative protein of unknown function, originally identified based on homology to <i>Ashbya gossypii</i> and other related yeasts"	1	0	0	0	0	0	0.85	0
3419_OG5_136765_7 - FUNGI_YJL163C	YJL163C	YJL163C - Putative protein of unknown function	1	0	0	0	0	0	0.85	0
3420_OG5_136992_7 - FUNGI_YFL013C	YFL013C	IES1 - Subunit of the INO80 chromatin remodeling complex	1	0	0	0	0	0	0.85	0
3421_OG5_137014_7 - FUNGI_YGL166W	YGL166W	CUP2 - Copper-binding transcription factor; activates transcription of the metallothionein genes CUP1-1 and CUP1-2 in response to elevated copper concentrations	1	0	0	0	0	0	0.85	0
3422_OG5_137014_7 - FUNGI_YPR008W	YPR008W	"HAA1 - Transcriptional activator involved in the transcription of TPO2, YRO2, and other genes putatively encoding membrane stress proteins; involved in adaptation to weak acid stress"	1	0	0	0	0	0	0.85	0
3423_OG5_137418_7 - FUNGI_YPR153W	YPR153W	YPR153W - Putative protein of unknown function	1	0	0	0	0	0	0.85	0
3424_OG5_137446_7 - FUNGI_YNL237W	YNL237W	"YTP1 - Probable type-III integral membrane protein of unknown function, has regions of similarity to mitochondrial electron transport proteins"	1	0	0	0	0	0	0.85	0
3425_OG5_137463_7 - FUNGI_YHR087W	YHR087W	"RTC3 - Protein of unknown function involved in RNA metabolism; has structural similarity to SBDS, the human protein mutated in Shwachman-Diamond Syndrome (the yeast SBDS ortholog = SDO1); null mutation suppresses cdc13-1 temperature sensitivity"	1	0	0	0	0	0	0.85	0
3426_OG5_137468_7 - FUNGI_YDR501W	YDR501W	PLM2 - Forkhead Associated domain containing protein and putative transcription factor found associated with chromatin; target of SBF transcription factor; induced in response to DNA damaging agents and deletion of telomerase; similar to TOS4	1	0	0	0	0	0	0.85	0
3427_OG5_137468_7 - FUNGI_YLR183C	YLR183C	TOS4 - Forkhead Associated domain containing protein and putative transcription factor found associated with chromatin; target of SBF transcription factor; expression is periodic and peaks in G1; similar to PLM2	1	0	0	0	0	0	0.85	0
3428_OG5_137724_7 - FUNGI_YJL096W	YJL096W	MRPL49 - Mitochondrial ribosomal protein of the large subunit	1	0	0	0	0	0	0.85	0
3429_OG5_137839_7 - FUNGI_YBR269C	YBR269C	"FMP21 - Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"	1	0	0	0	0	0	0.85	0
3430_OG5_137931_7 - FUNGI_YDR166C	YDR166C	"SEC5 - Essential 107kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosis"	1	0	0	0	0	0	0.85	0
3431_OG5_137935_7 - FUNGI_YLR063W	YLR063W	YLR063W - Putative S-adenosylmethionine-dependent methyltransferase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR063W is not an essential gene	1	0	0	0	0	0	0.85	0
3432_OG5_137963_7 - FUNGI_YJR112W-A	YJR112W-A	YJR112W-A - Putative protein of unknown function; identified based on homology to <i>Ashbya gossypii</i>	1	0	0	0	0	0	0.85	0
3433_OG5_137969_7 - FUNGI_YDR104C	YDR104C	"SPO71 - Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis"	1	0	0	0	0	0	0.85	0
3434_OG5_137984_7 - FUNGI_YHR082C	YHR082C	"KSP1 - Ser/thr protein kinase; nuclear translocation required for haploid filamentous growth; regulates filamentous growth induced nuclear translocation of Bcy1p, Fus3p, and Sks1p; overproduction causes allele-specific suppression of prp20-10"	1	0	0	0	0	0	0.85	0
3435_OG5_137992_7 - FUNGI_YDR079W	YDR079W	"PET100 - Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme"	1	0	0	0	0	0	0.85	0
3436_OG5_132095_7 - FUNGI_YKR043C	YKR043C	"SHB17 - Metal-independent fructose 1,6-bisphosphatase, may play a role in gluconeogenesis under metal-limiting conditions; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus"	1	0	0.194444444	0	0.095238095	0.142857143	0.85	0
3437_OG5_136869_7 - FUNGI_YJL085W	YJL085W	"EXO70 - Subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which directs secretory vesicles to active sites of exocytosis; acts with Sec3p in membrane targeting of the exocyst via PI(4,5)P2 binding"	1	0	0	0.125	0.047619048	0	0.85	0
3438_OG5_136994_7 - FUNGI_YGL181W	YGL181W	"GTS1 - Protein involved in Arf3p regulation and in transcription regulation; localizes to the nucleus and to endocytic patches; contains an N-terminal Zn-finger and ArfGAP homology domain, a C-terminal glutamine-rich region, and a UBA (ubiquitin associated) domain; gts1 mutations affect budding, cell size, heat tolerance, sporulation, life span, ultradian rhythms, endocytosis; expression oscillates in a pattern similar to metabolic oscillations"	1	0	0	0.125	0.047619048	0	0.85	0
3439_OG5_131940_7 - FUNGI_YJR152W	YJR152W	"DAL5 - Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression"	1	0	0	0	0.047619048	0.071428571	0.85	0
3440_OG5_135607_7 - FUNGI_YDR174W	YDR174W	"HMO1 - Chromatin associated high mobility group (HMG) family member involved in genome maintenance; rDNA-binding component of the Pol I transcription system; associates with a 5'-3' DNA helicase and Fpr1p, a prolyl isomerase"	1	0	0	0	0.047619048	0.071428571	0.85	0
3441_OG5_136982_7 - FUNGI_YDR498C	YDR498C	SEC20 - Membrane glycoprotein v-SNARE involved in retrograde transport from the Golgi to the ER; required for N- and O-glycosylation in the Golgi but not in the ER; interacts with the Dsl1p complex through Tip20p	1	0	0	0	0.047619048	0.071428571	0.85	0
3442_OG5_136953_7 - FUNGI_YDL199C	YDL199C	"YDL199C - Putative transporter, member of the sugar porter family"	1	0	0	0.125	0	0	0.85	0
3443_OG5_137401_7 - FUNGI_YIL140W	YIL140W	"AXL2 - Integral plasma membrane protein required for axial budding in haploid cells, localizes to the incipient bud site and bud neck; glycosylated by Pmt4p; potential Cdc28p substrate"	1	0	0	0.125	0	0	0.85	0
3444_OG5_134516_7 - FUNGI_YMR196W	YMR196W	YMR196W - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR196W is not an essential gene	1	0	0.027777778	0	0.19047619	0.071428571	0.85	0
3445_OG5_129098_7 - FUNGI_YPL150W	YPL150W	YPL150W - Putative protein kinase of unknown cellular role; binds phosphatidylinositols and cardiolipin in a large-scale study	1	0	0.027777778	0	0.19047619	0	0.85	0.125
3446_OG5_133965_7 - FUNGI_YBR286W	YBR286W	"APE3 - Vacuolar aminopeptidase Y, processed to mature form by Prb1p"	1	0.125	0.055555556	0.125	0.047619048	0	0.8	0
3447_OG5_135144_7 - FUNGI_YIR032C	YIR032C	"DAL3 - Ureidoglycolate hydrolase, converts ureidoglycolate to glyoxylate and urea in the third step of allantoin degradation; expression sensitive to nitrogen catabolite repression"	1	0	0.166666667	0	0	0	0.8	0
3448_OG5_137419_7 - FUNGI_YNL213C	YNL213C	"RRG9 - Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"	1	0	0	0	0.095238095	0	0.8	0
3449_OG5_137722_7 - FUNGI_YNL251C	YNL251C	"NRD1 - RNA-binding protein that interacts with the C-terminal domain of the RNA polymerase II large subunit (Rpo21p), preferentially at phosphorylated Ser5; required for transcription termination and 3' end maturation of nonpolyadenylated RNAs"	1	0	0	0	0	0.071428571	0.8	0
3450_OG5_137968_7 - FUNGI_YJR140C	YJR140C	"HIR3 - Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; involved in position-dependent gene silencing and nucleosome reassembly"	1	0	0	0	0	0.071428571	0.8	0
3451_OG5_137986_7 - FUNGI_YPL128C	YPL128C	"TBF1 - Telobox-containing general regulatory factor; binds TTAGGG repeats within subtelomeric anti-silencing regions (STARs), blocking silent chromatin propagation; binds majority of snoRNA gene promoters, required for full snoRNA expression"	1	0	0	0	0	0.071428571	0.8	0
3452_OG5_137999_7 - FUNGI_YCR003W	YCR003W	MRPL32 - Mitochondrial ribosomal protein of the large subunit	1	0	0	0	0	0.071428571	0.8	0
3453_OG5_135392_7 - FUNGI_YMR313C	YMR313C	TGL3 - Bifunctional enzyme with triacylglycerol lipase and lysophosphatidylethanolamine acyltransferase activity; responsible for all the triacylglycerol lipase activity of the lipid particle; required with Tgl4p for timely bud formation	1	0	0	0	0.047619048	0	0.8	0.125
3454_OG5_137252_7 - FUNGI_YOR249C	YOR249C	"APC5 - Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis"	1	0	0	0	0.047619048	0	0.8	0.0625
3455_OG5_137397_7 - FUNGI_YJR086W	YJR086W	"STE18 - G protein gamma subunit, forms a dimer with Ste4p to activate the mating signaling pathway, forms a heterotrimer with Gpa1p and Ste4p to dampen signaling; C-terminus is palmitoylated and farnesylated, which are required for normal signaling"	1	0	0	0	0.047619048	0	0.8	0
3456_OG5_137400_7 - FUNGI_YFL004W	YFL004W	"VTC2 - Subunit of the vacuolar transporter chaperone (VTC) complex involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion"	1	0	0	0	0.047619048	0	0.8	0
3457_OG5_137400_7 - FUNGI_YPL019C	YPL019C	"VTC3 - Subunit of the vacuolar transporter chaperone (VTC) complex involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion"	1	0	0	0	0.047619048	0	0.8	0
3458_OG5_137415_7 - FUNGI_YDR162C	YDR162C	"NBP2 - Protein involved in the HOG (high osmolarity glycerol) pathway, negatively regulates Hog1p by recruitment of phosphatase Ptc1p the Pbs2p-Hog1p complex, found in the nucleus and cytoplasm, contains an SH3 domain that binds Pbs2p"	1	0	0	0	0.047619048	0	0.8	0
3459_OG5_137420_7 - FUNGI_YDL076C	YDL076C	RXT3 - Subunit of the RPD3L complex; involved in histone deacetylation	1	0	0	0	0.047619048	0	0.8	0
3460_OG5_137434_7 - FUNGI_YPL016W	YPL016W	"SWI1 - Subunit of the SWI/SNF chromatin remodeling complex, which regulates transcription by remodeling chromosomes; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2; can form the prion [SWI+]"	1	0	0	0	0.047619048	0	0.8	0
3461_OG5_137728_7 - FUNGI_YJL112W	YJL112W	"MDV1 - Peripheral protein of the cytosolic face of the mitochondrial outer membrane, required for mitochondrial fission; interacts with Fis1p and with the dynamin-related GTPase Dnm1p; contains WD repeats"	1	0	0	0	0.047619048	0	0.8	0
3462_OG5_137728_7 - FUNGI_YKR036C	YKR036C	"CAF4 - WD40 repeat-containing protein associated with the CCR4-NOT complex, interacts in a Ccr4p-dependent manner with Ssn2p; also interacts with Fis1p, Mdv1p and Dnm1p and plays a role in mitochondrial fission"	1	0	0	0	0.047619048	0	0.8	0
3463_OG5_137820_7 - FUNGI_YER109C	YER109C	"FLO8 - Transcription factor required for flocculation, diploid filamentous growth, and haploid invasive growth; genome reference strain S288C and most laboratory strains have a mutation in this gene"	1	0	0	0	0.047619048	0	0.8	0
3464_OG5_137848_7 - FUNGI_YIL039W	YIL039W	TED1 - Conserved phosphoesterase domain-containing protein that acts together with Emp24p/Erv25p in cargo exit from the ER; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)	1	0	0	0	0.047619048	0	0.8	0
3465_OG5_137921_7 - FUNGI_YBR282W	YBR282W	MRPL27 - Mitochondrial ribosomal protein of the large subunit	1	0	0	0	0.047619048	0	0.8	0
3466_OG5_137973_7 - FUNGI_YLR287C	YLR287C	YLR287C - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR287C is not an essential gene	1	0	0	0	0.047619048	0	0.8	0
3467_OG5_137977_7 - FUNGI_YIR011C	YIR011C	STS1 - Protein required for localizing proteasomes to the nucleus; interacts with the karyopherin Srp1p; involved in ubiquitin-mediated protein degradation	1	0	0	0	0.047619048	0	0.8	0
3468_OG5_137993_7 - FUNGI_YFR001W	YFR001W	LOC1 - Nuclear protein involved in asymmetric localization of ASH1 mRNA; binds double-stranded RNA in vitro; constituent of 66S pre-ribosomal particles	1	0	0	0	0.047619048	0	0.8	0
3469_OG5_130970_7 - FUNGI_YIL166C	YIL166C	YIL166C - Putative protein with similarity to the allantoate permease (Dal5p) subfamily of the major facilitator superfamily; mRNA expression is elevated by sulfur limitation; YIL166C is a non-essential gene	1	0	0	0	0	0	0.8	0
3470_OG5_134260_7 - FUNGI_YOL030W	YOL030W	"GAS5 - 1,3-beta-glucanosyltransferase, has similarity to Gas1p; localizes to the cell wall"	1	0	0	0	0	0	0.8	0.0625
3471_OG5_134356_7 - FUNGI_YDR242W	YDR242W	AMD2 - Putative amidase	1	0	0	0	0	0	0.8	0
3472_OG5_134783_7 - FUNGI_YOR348C	YOR348C	"PUT4 - Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells"	1	0	0	0	0	0	0.8	0
3473_OG5_134792_7 - FUNGI_YGR282C	YGR282C	"BGL2 - Endo-beta-1,3-glucanase, major protein of the cell wall, involved in cell wall maintenance"	1	0	0	0	0	0	0.8	0.0625
3474_OG5_134796_7 - FUNGI_YGL077C	YGL077C	HNM1 - Choline/ethanolamine transporter; involved in the uptake of nitrogen mustard and the uptake of glycine betaine during hypersaline stress; co-regulated with phospholipid biosynthetic genes and negatively regulated by choline and myo-inositol	1	0	0	0	0	0	0.8	0
3475_OG5_134804_7 - FUNGI_YKL046C	YKL046C	"DCW1 - Putative mannosidase, GPI-anchored membrane protein required for cell wall biosynthesis in bud formation;homologous to Dfg5p"	1	0	0	0	0	0	0.8	0
3476_OG5_135401_7 - FUNGI_YAL053W	YAL053W	FLC2 - Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance	1	0	0	0	0	0	0.8	0
3477_OG5_136516_7 - FUNGI_YOR338W	YOR338W	YOR338W - Putative protein of unknown function; YOR338W transcription is regulated by Azf1p and its transcript is a specific target of the G protein effector Scp160p; identified as being required for sporulation in a high-throughput mutant screen	1	0	0	0	0	0	0.8	0
3478_OG5_136516_7 - FUNGI_YAL034C	YAL034C	FUN19 - Non-essential protein of unknown function; expression induced in response to heat stress	1	0	0	0	0	0	0.8	0
3479_OG5_136538_7 - FUNGI_YEL023C	YEL023C	YEL023C - Putative protein of unknown function; expression is increased greatly during sporulation; YEL023C is not an essential gene	1	0	0	0	0	0	0.8	0
3480_OG5_136545_7 - FUNGI_YGR273C	YGR273C	YGR273C - Putative protein of unknown function; expression downregulated by treatment with 8-methoxypsoralen plus UVA irradiation; YGR273C is not an essential gene	1	0	0	0	0	0	0.8	0
3481_OG5_136545_7 - FUNGI_YMR295C	YMR295C	YMR295C - Protein of unknown function that associates with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and bud; YMR295C is not an essential gene	1	0	0	0	0	0	0.8	0
3482_OG5_136886_7 - FUNGI_YIL107C	YIL107C	"PFK26 - 6-phosphofructo-2-kinase, inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate; has negligible fructose-2,6-bisphosphatase activity; transcriptional regulation involves protein kinase A"	1	0	0	0	0	0	0.8	0.0625
3483_OG5_137413_7 - FUNGI_YPR149W	YPR149W	NCE102 - Protein of unknown function; contains transmembrane domains; involved in secretion of proteins that lack classical secretory signal sequences; component of the detergent-insoluble glycolipid-enriched complexes (DIGs)	1	0	0	0	0	0	0.8	0
3484_OG5_137413_7 - FUNGI_YGR131W	YGR131W	"FHN1 - Protein of unknown function; induced by ketoconazole; promoter region contains sterol regulatory element motif, which has been identified as a Upc2p-binding site; overexpression complements function of Nce102p in NCE102 deletion strain"	1	0	0	0	0	0	0.8	0
3485_OG5_137430_7 - FUNGI_YLR456W	YLR456W	"YLR456W - Putative protein of unknown function; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2"	1	0	0	0	0	0	0.8	0
3486_OG5_137430_7 - FUNGI_YPR172W	YPR172W	"YPR172W - Protein of unknown function, transcriptionally activated by Yrm1p along with genes involved in multidrug resistance"	1	0	0	0	0	0	0.8	0
3487_OG5_137462_7 - FUNGI_YGR279C	YGR279C	SCW4 - Cell wall protein with similarity to glucanases; scw4 scw10 double mutants exhibit defects in mating	1	0	0	0	0	0	0.8	0
3488_OG5_137462_7 - FUNGI_YMR305C	YMR305C	SCW10 - Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on mutant phenotype and its regulation by Ste12p	1	0	0	0	0	0	0.8	0
3489_OG5_137752_7 - FUNGI_YOL148C	YOL148C	"SPT20 - Subunit of the SAGA transcriptional regulatory complex, involved in maintaining the integrity of the complex"	1	0	0	0	0	0	0.8	0
3490_OG5_137964_7 - FUNGI_YPR061C	YPR061C	"JID1 - Probable Hsp40p co-chaperone, has a DnaJ-like domain and appears to be involved in ER-associated degradation of misfolded proteins containing a tightly folded cytoplasmic domain; inhibits replication of Brome mosaic virus in S. cerevisiae"	1	0	0	0	0	0	0.8	0
3491_OG5_137990_7 - FUNGI_YGR174C	YGR174C	CBP4 - Mitochondrial protein required for assembly of cytochrome bc1 complex; interacts with the Cbp3p-Cbp6p complex and newly synthesized cytochrome b (Cobp) to promote assembly of Cobp into the cytochrome bc1 complex	1	0	0	0	0	0	0.8	0
3492_OG5_137996_7 - FUNGI_YOL072W	YOL072W	"THP1 - Nuclear pore-associated protein, forms a complex with Sac3p that is involved in transcription and in mRNA export from the nucleus; contains a PAM domain implicated in protein-protein binding"	1	0	0	0	0	0	0.8	0
3493_OG5_138043_7 - FUNGI_YNL070W	YNL070W	TOM7 - Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex	1	0	0	0	0	0	0.8	0
3494_OG5_138388_7 - FUNGI_YNL306W	YNL306W	"MRPS18 - Mitochondrial ribosomal protein of the small subunit; essential for viability, unlike most other mitoribosomal proteins"	1	0	0	0	0	0	0.8	0
3495_OG5_138399_7 - FUNGI_YKL092C	YKL092C	BUD2 - GTPase activating factor for Rsr1p/Bud1p required for both axial and bipolar budding patterns; mutants exhibit random budding in all cell types	1	0	0	0	0	0	0.8	0
3496_OG5_138415_7 - FUNGI_YKL181W	YKL181W	"PRS1 - 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes"	1	0	0	0	0	0	0.8	0
3497_OG5_138423_7 - FUNGI_YPR190C	YPR190C	RPC82 - RNA polymerase III subunit C82	1	0	0	0	0	0	0.8	0
3498_OG5_138434_7 - FUNGI_YEL015W	YEL015W	"EDC3 - Non-essential conserved protein of unknown function, plays a role in mRNA decapping by specifically affecting the function of the decapping enzyme Dcp1p; localizes to cytoplasmic mRNA processing bodies"	1	0	0	0	0	0	0.8	0
3499_OG5_138455_7 - FUNGI_YDR335W	YDR335W	"MSN5 - Karyopherin involved in nuclear import and export of proteins, including import of replication protein A and export of Swi6p, Far1p, and Pho4p; required for re-export of mature tRNAs after their retrograde import from the cytoplasm"	1	0	0	0	0	0	0.8	0
3500_OG5_138472_7 - FUNGI_YDR308C	YDR308C	SRB7 - Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; target of the global repressor Tup1p	1	0	0	0	0	0	0.8	0
3501_OG5_138559_7 - FUNGI_YKL194C	YKL194C	MST1 - Mitochondrial threonyl-tRNA synthetase	1	0	0	0	0	0	0.8	0
3502_OG5_138576_7 - FUNGI_YAL009W	YAL009W	"SPO7 - Putative regulatory subunit of Nem1p-Spo7p phosphatase holoenzyme, regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology, premeiotic replication, and sporulation"	1	0	0	0	0	0	0.8	0
3503_OG5_138578_7 - FUNGI_YDL045W-A	YDL045W-A	MRP10 - Mitochondrial ribosomal protein of the small subunit; contains twin cysteine-x9-cysteine motifs	1	0	0	0	0	0	0.8	0
3504_OG5_138579_7 - FUNGI_YNL073W	YNL073W	"MSK1 - Mitochondrial lysine-tRNA synthetase, required for import of both aminoacylated and deacylated forms of tRNA(Lys) into mitochondria and for aminoacylation of mitochondrially encoded tRNA(Lys)"	1	0	0	0	0	0	0.8	0
3505_OG5_138580_7 - FUNGI_YPR079W	YPR079W	"MRL1 - Membrane protein with similarity to mammalian mannose-6-phosphate receptors, possibly functions as a sorting receptor in the delivery of vacuolar hydrolases"	1	0	0	0	0	0	0.8	0
3506_OG5_138588_7 - FUNGI_YDL133W	YDL133W	"SRF1 - Regulator of phospholipase D (Spo14p); interacts with Spo14p and regulates its catalytic activity; capable of buffering the toxicity of C16:0 platelet activating factor, a lipid that accumulates intraneuronally in Alzheimer's patients"	1	0	0	0	0	0	0.8	0
3507_OG5_138589_7 - FUNGI_YNL084C	YNL084C	"END3 - EH domain-containing protein involved in endocytosis, actin cytoskeletal organization and cell wall morphogenesis; forms a complex with Sla1p and Pan1p"	1	0	0	0	0	0	0.8	0
3508_OG5_138590_7 - FUNGI_YML103C	YML103C	"NUP188 - Subunit of the nuclear pore complex (NPC), involved in the structural organization of the complex and of the nuclear envelope, also involved in nuclear envelope permeability, interacts with Pom152p and Nic96p"	1	0	0	0	0	0	0.8	0
3509_OG5_138594_7 - FUNGI_YLR014C	YLR014C	"PPR1 - Zinc finger transcription factor containing a Zn(2)-Cys(6) binuclear cluster domain, positively regulates transcription of genes involved in uracil biosynthesis; activity may be modulated by interaction with Tup1p"	1	0	0	0	0	0	0.8	0
3510_OG5_138596_7 - FUNGI_YGL023C	YGL023C	"PIB2 - Protein binding phosphatidylinositol 3-phosphate, involved in telomere-proximal repression of gene expression; similar to Fab1 and Vps27"	1	0	0	0	0	0	0.8	0
3511_OG5_138601_7 - FUNGI_YPL050C	YPL050C	"MNN9 - Subunit of Golgi mannosyltransferase complex also containing Anp1p, Mnn10p, Mnn11p, and Hoc1p that mediates elongation of the polysaccharide mannan backbone; forms a separate complex with Van1p that is also involved in backbone elongation"	1	0	0	0	0	0	0.8	0
3512_OG5_138608_7 - FUNGI_YPL254W	YPL254W	"HFI1 - Adaptor protein required for structural integrity of the SAGA complex, a histone acetyltransferase-coactivator complex that is involved in global regulation of gene expression through acetylation and transcription functions"	1	0	0	0	0	0	0.8	0
3513_OG5_138610_7 - FUNGI_YKL078W	YKL078W	"DHR2 - Predominantly nucleolar DEAH-box ATP-dependent RNA helicase, required for 18S rRNA synthesis"	1	0	0	0	0	0	0.8	0
3514_OG5_138615_7 - FUNGI_YDL111C	YDL111C	RRP42 - Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp42p (EXOSC7)	1	0	0	0	0	0	0.8	0
3515_OG5_138616_7 - FUNGI_YPR139C	YPR139C	VPS66 - Cytoplasmic protein of unknown function involved in vacuolar protein sorting.	1	0	0	0	0	0	0.8	0
3516_OG5_138618_7 - FUNGI_YEL036C	YEL036C	"ANP1 - Subunit of the alpha-1,6 mannosyltransferase complex; type II membrane protein; has a role in retention of glycosyltransferases in the Golgi; involved in osmotic sensitivity and resistance to aminonitrophenyl propanediol"	1	0	0	0	0	0	0.8	0
3517_OG5_138623_7 - FUNGI_YMR033W	YMR033W	ARP9 - Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation	1	0	0	0	0	0	0.8	0
3518_OG5_138630_7 - FUNGI_YBR040W	YBR040W	"FIG1 - Integral membrane protein required for efficient mating; may participate in or regulate the low affinity Ca2+ influx system, which affects intracellular signaling and cell-cell fusion during mating"	1	0	0	0	0	0	0.8	0
3519_OG5_138633_7 - FUNGI_YPL233W	YPL233W	NSL1 - Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; required for accurate chromosome segregation	1	0	0	0	0	0	0.8	0
3520_OG5_138634_7 - FUNGI_YGL215W	YGL215W	CLG1 - Cyclin-like protein that interacts with Pho85p; has sequence similarity to G1 cyclins PCL1 and PCL2	1	0	0	0	0	0	0.8	0
3521_OG5_138637_7 - FUNGI_YDR362C	YDR362C	TFC6 - One of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; cooperates with Tfc3p in DNA binding; human homolog is TFIIIC-110	1	0	0	0	0	0	0.8	0
3522_OG5_138641_7 - FUNGI_YOL061W	YOL061W	"PRS5 - 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes"	1	0	0	0	0	0	0.8	0
3523_OG5_138643_7 - FUNGI_YFL026W	YFL026W	STE2 - Receptor for alpha-factor pheromone; seven transmembrane-domain GPCR that interacts with both pheromone and a heterotrimeric G protein to initiate the signaling response that leads to mating between haploid a and alpha cells	1	0	0	0	0	0	0.8	0
3524_OG5_138650_7 - FUNGI_YBR193C	YBR193C	MED8 - Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation	1	0	0	0	0	0	0.8	0
3525_OG5_138651_7 - FUNGI_YGR076C	YGR076C	MRPL25 - Mitochondrial ribosomal protein of the large subunit	1	0	0	0	0	0	0.8	0
3526_OG5_138654_7 - FUNGI_YDL167C	YDL167C	NRP1 - Putative RNA binding protein of unknown function; localizes to stress granules induced by glucose deprivation; predicted to be involved in ribosome biogenesis	1	0	0	0	0	0	0.8	0
3527_OG5_138656_7 - FUNGI_YDL117W	YDL117W	CYK3 - SH3-domain protein located in the mother-bud neck and the cytokinetic actin ring; mutant phenotype and genetic interactions suggest a role in cytokinesis	1	0	0	0	0	0	0.8	0
3528_OG5_138658_7 - FUNGI_YIL019W	YIL019W	FAF1 - Protein required for pre-rRNA processing and 40S ribosomal subunit assembly	1	0	0	0	0	0	0.8	0
3529_OG5_138660_7 - FUNGI_YOL110W	YOL110W	"SHR5 - Subunit of a palmitoyltransferase, composed of Shr5p and Erf2p, that adds a palmitoyl lipid moiety to heterolipidated substrates such as Ras1p and Ras2p through a thioester linkage; palmitoylation is required for Ras2p membrane localization"	1	0	0	0	0	0	0.8	0
3530_OG5_138664_7 - FUNGI_YLR312W-A	YLR312W-A	MRPL15 - Mitochondrial ribosomal protein of the large subunit	1	0	0	0	0	0	0.8	0
3531_OG5_138665_7 - FUNGI_YPL129W	YPL129W	"TAF14 - Subunit of TFIID, TFIIF, INO80, SWI/SNF, and NuA3 complexes, involved in RNA polymerase II transcription initiation and in chromatin modification; contains a YEATS domain"	1	0	0	0	0	0	0.8	0
3532_OG5_138670_7 - FUNGI_YHR187W	YHR187W	"IKI1 - Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; iki1 mutations confer resistance to the K. lactis toxin zymocin"	1	0	0	0	0	0	0.8	0
3533_OG5_138676_7 - FUNGI_YPL066W	YPL066W	YPL066W - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the bud neck and cytoplasm; null mutant is viable and exhibits growth defect on a non-fermentable (respiratory) carbon source	1	0	0	0	0	0	0.8	0
3534_OG5_138679_7 - FUNGI_YER059W	YER059W	PCL6 - Pho85p cyclin of the Pho80p subfamily; forms the major Glc8p kinase together with Pcl7p and Pho85p; involved in the control of glycogen storage by Pho85p; stabilized by Elongin C binding	1	0	0	0	0	0	0.8	0
3535_OG5_138719_7 - FUNGI_YPL041C	YPL041C	YPL041C - Protein of unknown function involved in maintenance of proper telomere length	1	0	0	0	0	0	0.8	0
3536_OG5_138722_7 - FUNGI_YMR200W	YMR200W	"ROT1 - Molecular chaperone involved in protein folding in the ER; mutation causes defects in cell wall synthesis and in lysis of autophagic bodies, suppresses tor2 mutations, and is synthetically lethal with kar2-1 and with rot2 mutations"	1	0	0	0	0	0	0.8	0
3537_OG5_139340_7 - FUNGI_YOR078W	YOR078W	BUD21 - Component of small ribosomal subunit (SSU) processosome that contains U3 snoRNA; originally isolated as bud-site selection mutant that displays a random budding pattern	1	0	0	0	0	0	0.8	0
3538_OG5_139344_7 - FUNGI_YMR117C	YMR117C	"SPC24 - Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering"	1	0	0	0	0	0	0.8	0
3539_OG5_139395_7 - FUNGI_YOL026C	YOL026C	"MIM1 - Mitochondrial outer membrane protein, involved in the insertion of TOM (translocase of outer membrane) complex components into the membrane and required for assembly of the TOM complex; mutants display impaired mitochondrial protein import"	1	0	0	0	0	0	0.8	0
3540_OG5_134430_7 - FUNGI_YIR038C	YIR038C	"GTT1 - ER associated glutathione S-transferase capable of homodimerization; expression induced during the diauxic shift and throughout stationary phase; functional overlap with Gtt2p, Grx1p, and Grx2p"	1	0	0.055555556	0.125	0.095238095	0	0.8	0
3541_OG5_135397_7 - FUNGI_YBR016W	YBR016W	"YBR016W - Tail-anchored plasma membrane protein containing a conserved CYSTM module; predicted to be palmitoylated; has similarity to hydrophilins, which are involved in the adaptive response to hyperosmotic conditions"	1	0	0	0.125	0.095238095	0	0.8	0.0625
3542_OG5_135397_7 - FUNGI_YDL012C	YDL012C	"YDL012C - Tail-anchored plasma membrane protein containing a conserved CYSTM module, possibly involved in response to stress; may contribute to non-homologous end-joining (NHEJ) based on ydl012c htz1 double null phenotype"	1	0	0	0.125	0.095238095	0	0.8	0.0625
3543_OG5_135140_7 - FUNGI_YDR058C	YDR058C	TGL2 - Triacylglycerol lipase that is localized to the mitochondria; has lipolytic activity towards triacylglycerols and diacylglycerols when expressed in E. coli	1	0	0.138888889	0	0.095238095	0	0.8	0
3544_OG5_137423_7 - FUNGI_YDR245W	YDR245W	"MNN10 - Subunit of a Golgi mannosyltransferase complex also containing Anp1p, Mnn9p, Mnn11p, and Hoc1p that mediates elongation of the polysaccharide mannan backbone; membrane protein of the mannosyltransferase family"	1	0	0	0.125	0.047619048	0	0.8	0
3545_OG5_137431_7 - FUNGI_YGR105W	YGR105W	"VMA21 - Integral membrane protein that is required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the yeast endoplasmic reticulum (ER)"	1	0	0	0.125	0.047619048	0	0.8	0
3546_OG5_136511_7 - FUNGI_YHR155W	YHR155W	YSP1 - Mitochondrial protein with a potential role in promoting mitochondrial fragmentation during programmed cell death in response to high levels of alpha-factor mating pheromone or the drug amiodarone	1	0	0	0	0.047619048	0.071428571	0.8	0
3547_OG5_136511_7 - FUNGI_YNL257C	YNL257C	"SIP3 - Protein that activates transcription through interaction with DNA-bound Snf1p, C-terminal region has a putative leucine zipper motif; potential Cdc28p substrate"	1	0	0	0	0.047619048	0.071428571	0.8	0
3548_OG5_137428_7 - FUNGI_YNL224C	YNL224C	SQS1 - Stimulates the ATPase and helicase activities of Prp43p; acts with Prp43p to stimulate 18s rRNA maturation by Nob1p; overexpression antagonizes the suppression of splicing defects by spp382 mutants; component of pre-ribosomal particles	1	0	0	0	0.047619048	0.071428571	0.8	0
3549_OG5_135928_7 - FUNGI_YDR233C	YDR233C	"RTN1 - ER membrane protein that interacts with Sey1p to maintain ER morphology; interacts with exocyst subunit Sec6p, with Yip3p, and with Sbh1p; null mutant has an altered ER morphology; member of the RTNLA (reticulon-like A) subfamily"	1	0	0	0.125	0	0.071428571	0.8	0.0625
3550_OG5_135128_7 - FUNGI_YBR078W	YBR078W	"ECM33 - GPI-anchored protein of unknown function, has a possible role in apical bud growth; GPI-anchoring on the plasma membrane crucial to function; phosphorylated in mitochondria; similar to Sps2p and Pst1p"	1	0	0	0.125	0	0	0.8	0
3551_OG5_136169_7 - FUNGI_YIL123W	YIL123W	"SIM1 - Protein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p) that may participate in DNA replication, promoter contains SCB regulation box at -300 bp indicating that expression may be cell cycle-regulated"	1	0	0	0.125	0	0	0.8	0
3552_OG5_136169_7 - FUNGI_YNL066W	YNL066W	"SUN4 - Cell wall protein related to glucanases, possibly involved in cell wall septation; member of the SUN family"	1	0	0	0.125	0	0	0.8	0
3553_OG5_137817_7 - FUNGI_YNL053W	YNL053W	"MSG5 - Dual-specificity protein phosphatase; exists in 2 isoforms; required for maintenance of a low level of signaling through the cell integrity pathway, adaptive response to pheromone; regulates and is regulated by Slt2p; dephosphorylates Fus3p"	1	0	0	0.125	0	0	0.8	0
3554_OG5_137979_7 - FUNGI_YJL183W	YJL183W	"MNN11 - Subunit of a Golgi mannosyltransferase complex that also contains Anp1p, Mnn9p, Mnn10p, and Hoc1p, and mediates elongation of the polysaccharide mannan backbone; has homology to Mnn10p"	1	0	0	0.125	0	0	0.8	0
3555_OG5_135740_7 - FUNGI_YBR204C	YBR204C	"LDH1 - Serine hydrolase; exhibits active esterase plus weak triacylglycerol lipase activities; proposed role in lipid homeostasis, regulating phospholipid and non-polar lipid levels and required for mobilization of LD-stored lipids; localizes to the lipid droplet (LD) surface; contains a classical serine containing catalytic triad (GxSxG motif)"	1	0	0.027777778	0.125	0.142857143	0	0.8	0.0625
3556_OG5_134990_7 - FUNGI_YIL045W	YIL045W	PIG2 - Putative type-1 protein phosphatase targeting subunit that tethers Glc7p type-1 protein phosphatase to Gsy2p glycogen synthase	1	0	0	0	0.142857143	0.142857143	0.8	0
3557_OG5_133549_7 - FUNGI_YCR021C	YCR021C	"HSP30 - Hydrophobic plasma membrane localized, stress-responsive protein that negatively regulates the H(+)-ATPase Pma1p; induced by heat shock, ethanol treatment, weak organic acid, glucose limitation, and entry into stationary phase"	1	0.125	0	0	0	0	0.75	0
3558_OG5_133549_7 - FUNGI_YBR054W	YBR054W	"YRO2 - Protein of unknown function with similarity to archaeal rhodopsins; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; transcriptionally regulated by Haa1p"	1	0.125	0	0	0	0	0.75	0
3559_OG5_133549_7 - FUNGI_YDR033W	YDR033W	"MRH1 - Protein that localizes primarily to the plasma membrane, also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; has similarity to Hsp30p and Yro2p"	1	0.125	0	0	0	0	0.75	0
3560_OG5_136901_7 - FUNGI_YPL177C	YPL177C	"CUP9 - Homeodomain-containing transcriptional repressor of PTR2, which encodes a major peptide transporter; imported peptides activate ubiquitin-dependent proteolysis, resulting in degradation of Cup9p and de-repression of PTR2 transcription"	1	0	0	0	0.095238095	0	0.75	0.0625
3561_OG5_135396_7 - FUNGI_YIR030C	YIR030C	"DCG1 - Protein of unknown function, expression is sensitive to nitrogen catabolite repression and regulated by Dal80p; contains transmembrane domain"	1	0	0.083333333	0	0	0	0.75	0
3562_OG5_138411_7 - FUNGI_YBL103C	YBL103C	"RTG3 - Basic helix-loop-helix-leucine zipper (bHLH/Zip) transcription factor that forms a complex with another bHLH/Zip protein, Rtg1p, to activate the retrograde (RTG) and TOR pathways"	1	0	0	0	0	0.071428571	0.75	0
3563_OG5_138476_7 - FUNGI_YBL107C	YBL107C	YBL107C - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YBL107C is not an essential gene	1	0	0	0	0	0.071428571	0.75	0
3564_OG5_130472_7 - FUNGI_YBR298C	YBR298C	"MAL31 - Maltose permease, high-affinity maltose transporter (alpha-glucoside transporter); encoded in the MAL3 complex locus; member of the 12 transmembrane domain superfamily of sugar transporters; functional in genomic reference strain S288C"	1	0	0	0	0.047619048	0	0.75	0
3565_OG5_130472_7 - FUNGI_YGR289C	YGR289C	MAL11 - Inducible high-affinity maltose transporter (alpha-glucoside transporter); encoded in the MAL1 complex locus; broad substrate specificity that includes maltotriose; required for isomaltose utilization	1	0	0	0	0.047619048	0	0.75	0
3566_OG5_130472_7 - FUNGI_YDL247W	YDL247W	"MPH2 - Alpha-glucoside permease, transports maltose, maltotriose, alpha-methylglucoside, and turanose; identical to Mph3p; encoded in a subtelomeric position in a region likely to have undergone duplication"	1	0	0	0	0.047619048	0	0.75	0
3567_OG5_130472_7 - FUNGI_YJR160C	YJR160C	"MPH3 - Alpha-glucoside permease, transports maltose, maltotriose, alpha-methylglucoside, and turanose; identical to Mph2p; encoded in a subtelomeric position in a region likely to have undergone duplication"	1	0	0	0	0.047619048	0	0.75	0
3568_OG5_136873_7 - FUNGI_YJL110C	YJL110C	GZF3 - GATA zinc finger protein and Dal80p homolog that negatively regulates nitrogen catabolic gene expression by competing with Gat1p for GATA site binding; function requires a repressive carbon source; dimerizes with Dal80p and binds to Tor1p	1	0	0	0	0.047619048	0	0.75	0.0625
3569_OG5_136873_7 - FUNGI_YKR034W	YKR034W	"DAL80 - Negative regulator of genes in multiple nitrogen degradation pathways; expression is regulated by nitrogen levels and by Gln3p; member of the GATA-binding family, forms homodimers and heterodimers with Deh1p"	1	0	0	0	0.047619048	0	0.75	0.0625
3570_OG5_137440_7 - FUNGI_YBR288C	YBR288C	APM3 - Mu3-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway	1	0	0	0	0.047619048	0	0.75	0.125
3571_OG5_137920_7 - FUNGI_YJL025W	YJL025W	"RRN7 - Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p"	1	0	0	0	0.047619048	0	0.75	0
3572_OG5_137924_7 - FUNGI_YER030W	YER030W	CHZ1 - Histone chaperone for Htz1p/H2A-H2B dimer; required for the stabilization of the Chz1p-Htz1-H2B complex; has overlapping function with Nap1p; null mutant displays weak sensitivity to MMS and benomyl; contains a highly conserved CHZ motif	1	0	0	0	0.047619048	0	0.75	0.0625
3573_OG5_138507_7 - FUNGI_YAL013W	YAL013W	"DEP1 - Transcriptional modulator involved in regulation of structural phospholipid biosynthesis genes and metabolically unrelated genes, as well as maintenance of telomeres, mating efficiency, and sporulation"	1	0	0	0	0.047619048	0	0.75	0
3574_OG5_138659_7 - FUNGI_YNL151C	YNL151C	RPC31 - RNA polymerase III subunit C31	1	0	0	0	0.047619048	0	0.75	0
3575_OG5_134813_7 - FUNGI_YDR536W	YDR536W	"STL1 - Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock"	1	0	0	0	0	0	0.75	0
3576_OG5_135775_7 - FUNGI_YGR197C	YGR197C	SNG1 - Protein involved in resistance to nitrosoguanidine (MNNG) and 6-azauracil (6-AU); expression is regulated by transcription factors involved in multidrug resistance	1	0	0	0	0	0	0.75	0
3577_OG5_135794_7 - FUNGI_YPR022C	YPR022C	YPR022C - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS	1	0	0	0	0	0	0.75	0
3578_OG5_136106_7 - FUNGI_YBR096W	YBR096W	YBR096W - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the ER	1	0	0	0	0	0	0.75	0
3579_OG5_136546_7 - FUNGI_YBR151W	YBR151W	"APD1 - Protein of unknown function, required for normal localization of actin patches and for normal tolerance of sodium ions and hydrogen peroxide; localizes to both cytoplasm and nucleus"	1	0	0	0	0	0	0.75	0
3580_OG5_136624_7 - FUNGI_YDR003W	YDR003W	"RCR2 - Vacuolar protein that presumably functions within the endosomal-vacuolar trafficking pathway, affecting events that determine whether plasma membrane proteins are degraded or routed to the plasma membrane; similar to Rcr1p"	1	0	0	0	0	0	0.75	0
3581_OG5_136624_7 - FUNGI_YBR005W	YBR005W	"RCR1 - Protein of the ER membrane involved in cell wall chitin deposition; may function in the endosomal-vacuolar trafficking pathway, helping determine whether plasma membrane proteins are degraded or routed to the plasma membrane"	1	0	0	0	0	0	0.75	0
3582_OG5_136978_7 - FUNGI_YDR444W	YDR444W	YDR444W - Putative protein of unknown function	1	0	0	0	0	0	0.75	0
3583_OG5_136978_7 - FUNGI_YGL144C	YGL144C	ROG1 - Protein with putative serine active lipase domain	1	0	0	0	0	0	0.75	0
3584_OG5_137933_7 - FUNGI_YOR227W	YOR227W	"HER1 - Protein of unknown function required for proliferation or remodeling of the ER that is caused by overexpression of Hmg2p; may interact with ribosomes, based on co-purification experiments"	1	0	0	0	0	0	0.75	0
3585_OG5_137933_7 - FUNGI_YPL137C	YPL137C	"GIP3 - Glc7-interacting protein whose overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; may interact with ribosomes, based on co-purification experiments"	1	0	0	0	0	0	0.75	0
3586_OG5_137944_7 - FUNGI_YMR016C	YMR016C	SOK2 - Nuclear protein that plays a regulatory role in the cyclic AMP (cAMP)-dependent protein kinase (PKA) signal transduction pathway; negatively regulates pseudohyphal differentiation; homologous to several transcription factors	1	0	0	0	0	0	0.75	0
3587_OG5_137944_7 - FUNGI_YKL043W	YKL043W	"PHD1 - Transcriptional activator that enhances pseudohyphal growth; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; regulates expression of FLO11, an adhesin required for pseudohyphal filament formation; similar to StuA, an A. nidulans developmental regulator; potential Cdc28p substrate"	1	0	0	0	0	0	0.75	0
3588_OG5_137947_7 - FUNGI_YLL012W	YLL012W	"YEH1 - Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes"	1	0	0	0	0	0	0.75	0
3589_OG5_137947_7 - FUNGI_YLR020C	YLR020C	"YEH2 - Steryl ester hydrolase, catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism"	1	0	0	0	0	0	0.75	0
3590_OG5_137971_7 - FUNGI_YER022W	YER022W	SRB4 - Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; similar to the human MED17 gene	1	0	0	0	0	0	0.75	0
3591_OG5_137995_7 - FUNGI_YMR119W	YMR119W	ASI1 - Putative integral membrane E3 ubiquitin ligase; acts with Asi2p and Asi3p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals	1	0	0	0	0	0	0.75	0
3592_OG5_137995_7 - FUNGI_YNL008C	YNL008C	ASI3 - Putative integral membrane E3 ubiquitin ligase; acts with Asi1p and Asi2p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals	1	0	0	0	0	0	0.75	0
3593_OG5_138420_7 - FUNGI_YOL108C	YOL108C	"INO4 - Transcription factor required for derepression of inositol-choline-regulated genes involved in phospholipid synthesis; forms a complex, with Ino2p, that binds the inositol-choline-responsive element through a basic helix-loop-helix domain"	1	0	0	0	0	0	0.75	0
3594_OG5_138602_7 - FUNGI_YBR167C	YBR167C	"POP7 - Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs"	1	0	0	0	0	0	0.75	0
3595_OG5_138606_7 - FUNGI_YGL164C	YGL164C	"YRB30 - RanGTP-binding protein, inhibits RanGAP1 (Rna1p)-mediated GTP hydrolysis of RanGTP (Gsp1p); shares similarity to proteins in other fungi but not in higher eukaryotes"	1	0	0	0	0	0	0.75	0
3596_OG5_138625_7 - FUNGI_YOR228C	YOR228C	"YOR228C - Protein of unknown function, localized to the mitochondrial outer membrane"	1	0	0	0	0	0	0.75	0
3597_OG5_138657_7 - FUNGI_YKL103C	YKL103C	LAP4 - Vacuolar aminopeptidase yscI; zinc metalloproteinase that belongs to the peptidase family M18; often used as a marker protein in studies of autophagy and cytosol to vacuole targeting (CVT) pathway	1	0	0	0	0	0	0.75	0
3598_OG5_138666_7 - FUNGI_YNL294C	YNL294C	"RIM21 - Component of the RIM101 pathway, has a role in cell wall construction and alkaline pH response; has similarity to A. nidulans PalH"	1	0	0	0	0	0	0.75	0
3599_OG5_138716_7 - FUNGI_YKL122C	YKL122C	"SRP21 - Subunit of the signal recognition particle (SRP), which functions in protein targeting to the endoplasmic reticulum membrane; not found in mammalian SRP; forms a pre-SRP structure in the nucleolus that is translocated to the cytoplasm"	1	0	0	0	0	0	0.75	0
3600_OG5_139094_7 - FUNGI_YEL009C	YEL009C	GCN4 - Basic leucine zipper (bZIP) transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels	1	0	0	0	0	0	0.75	0
3601_OG5_139148_7 - FUNGI_YPR169W	YPR169W	"JIP5 - Essential protein required for biogenesis of the large ribosomal subunit; interacts with proteins involved in RNA processing, ribosome biogenesis, ubiquitination and demethylation; similar to WDR55, a human WD repeat protein"	1	0	0	0	0	0	0.75	0
3602_OG5_139165_7 - FUNGI_YMR159C	YMR159C	"ATG16 - Conserved protein that interacts with Atg12p-Atg5p conjugates to form Atg12p-Atg5p-Atg16p multimers, which localize to the pre-autophagosomal structure and are required for autophagy"	1	0	0	0	0	0	0.75	0
3603_OG5_139242_7 - FUNGI_YJL039C	YJL039C	"NUP192 - Essential structural subunit of the nuclear pore complex (NPC), localizes to the nuclear periphery of nuclear pores, homologous to human p205"	1	0	0	0	0	0	0.75	0
3604_OG5_139276_7 - FUNGI_YCR046C	YCR046C	"IMG1 - Mitochondrial ribosomal protein of the large subunit, required for respiration and for maintenance of the mitochondrial genome"	1	0	0	0	0	0	0.75	0
3605_OG5_139306_7 - FUNGI_YNL115C	YNL115C	YNL115C - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL115C is not an essential gene	1	0	0	0	0	0	0.75	0
3606_OG5_139316_7 - FUNGI_YGR053C	YGR053C	YGR053C - Putative protein of unknown function	1	0	0	0	0	0	0.75	0
3607_OG5_139319_7 - FUNGI_YML002W	YML002W	YML002W - Putative protein of unknown function; expression induced by heat and by calcium shortage	1	0	0	0	0	0	0.75	0
3608_OG5_139324_7 - FUNGI_YMR244W	YMR244W	YMR244W - Putative protein of unknown function	1	0	0	0	0	0	0.75	0
3609_OG5_139327_7 - FUNGI_YDR132C	YDR132C	YDR132C - Putative protein of unknown function	1	0	0	0	0	0	0.75	0
3610_OG5_139332_7 - FUNGI_YLR451W	YLR451W	"LEU3 - Zinc-finger transcription factor that regulates genes involved in branched chain amino acid biosynthesis and ammonia assimilation; positively regulated by alpha-isopropylmalate, an intermediate in leucine biosynthesis"	1	0	0	0	0	0	0.75	0
3611_OG5_139335_7 - FUNGI_YLR071C	YLR071C	"RGR1 - Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for glucose repression, HO repression, RME1 repression and sporulation"	1	0	0	0	0	0	0.75	0
3612_OG5_139345_7 - FUNGI_YNL015W	YNL015W	"PBI2 - Cytosolic inhibitor of vacuolar proteinase B (PRB1), required for efficient vacuole inheritance; with thioredoxin forms protein complex LMA1, which assists in priming SNARE molecules and promotes vacuole fusion"	1	0	0	0	0	0	0.75	0
3613_OG5_139356_7 - FUNGI_YLR047C	YLR047C	"FRE8 - Protein with sequence similarity to iron/copper reductases, involved in iron homeostasis; deletion mutant has iron deficiency/accumulation growth defects; expression increased in the absence of copper-responsive transcription factor Mac1p"	1	0	0	0	0	0	0.75	0
3614_OG5_139358_7 - FUNGI_YIR023W	YIR023W	DAL81 - Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism	1	0	0	0	0	0	0.75	0
3615_OG5_139363_7 - FUNGI_YMR127C	YMR127C	"SAS2 - Histone acetyltransferase (HAT) catalytic subunit of the SAS complex (Sas2p-Sas4p-Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; member of the MYSTacetyltransferase family"	1	0	0	0	0	0	0.75	0
3616_OG5_139364_7 - FUNGI_YNL051W	YNL051W	"COG5 - Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments"	1	0	0	0	0	0	0.75	0
3617_OG5_139368_7 - FUNGI_YMR071C	YMR071C	"TVP18 - Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; may interact with ribosomes, based on co-purification experiments"	1	0	0	0	0	0	0.75	0
3618_OG5_139371_7 - FUNGI_YPL072W	YPL072W	"UBP16 - Deubiquitinating enzyme anchored to the outer mitochondrial membrane, probably not important for general mitochondrial functioning, but may perform a more specialized function at mitochondria"	1	0	0	0	0	0	0.75	0
3619_OG5_139378_7 - FUNGI_YDL067C	YDL067C	"COX9 - Subunit VIIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain"	1	0	0	0	0	0	0.75	0
3620_OG5_139382_7 - FUNGI_YDR259C	YDR259C	YAP6 - Putative basic leucine zipper (bZIP) transcription factor; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; overexpression increases sodium and lithium tolerance; computational analysis suggests a role in regulation of expression of genes involved in carbohydrate metabolism	1	0	0	0	0	0	0.75	0
3621_OG5_139385_7 - FUNGI_YDR254W	YDR254W	"CHL4 - Outer kinetochore protein required for chromosome stability; involved in new kinetochore assembly and sister chromatid cohesion; peripheral component of the Ctf19 kinetochore subcomplex that interacts with Ctf19p, Ctf3p, Iml3p and Mif2p"	1	0	0	0	0	0	0.75	0
3622_OG5_139389_7 - FUNGI_YHR191C	YHR191C	CTF8 - Subunit of a complex with Ctf18p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion	1	0	0	0	0	0	0.75	0
3623_OG5_139391_7 - FUNGI_YLR352W	YLR352W	YLR352W - Putative protein of unknown function with similarity to F-box proteins; interacts with Skp1p and Cdc53p; YLR352W is not an essential gene	1	0	0	0	0	0	0.75	0
3624_OG5_139396_7 - FUNGI_YFR034C	YFR034C	PHO4 - Basic helix-loop-helix (bHLH) transcription factor of the myc-family; binds cooperatively with Pho2p to the PHO5 promoter; function is regulated by phosphorylation at multiple sites and by phosphate availability	1	0	0	0	0	0	0.75	0
3625_OG5_139398_7 - FUNGI_YHL028W	YHL028W	WSC4 - ER membrane protein involved in the translocation of soluble secretory proteins and insertion of membrane proteins into the ER membrane; may also have a role in the stress response but has only partial functional overlap with WSC1-3	1	0	0	0	0	0	0.75	0
3626_OG5_139409_7 - FUNGI_YOR037W	YOR037W	"CYC2 - Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)"	1	0	0	0	0	0	0.75	0
3627_OG5_139410_7 - FUNGI_YLR145W	YLR145W	"RMP1 - Subunit of RNase MRP, which processes pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; unlike most subunits, not shared between RNase MRP and nuclear RNase P"	1	0	0	0	0	0	0.75	0
3628_OG5_139411_7 - FUNGI_YLR414C	YLR414C	PUN1 - Putative protein of unknown function; localizes to bud and cytoplasm; co-localizes with Sur7p in punctate patches in the plasma membrane; null mutant displays decreased thermotolerance; transcription induced on cell wall damage	1	0	0	0	0	0	0.75	0
3629_OG5_139412_7 - FUNGI_YOR104W	YOR104W	PIN2 - Protein that induces appearance of [PIN+] prion when overproduced; predicted to be palmitoylated	1	0	0	0	0	0	0.75	0
3630_OG5_139415_7 - FUNGI_YJR080C	YJR080C	"AIM24 - Protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays reduced respiratory growth and elevated frequency of mitochondrial genome loss"	1	0	0	0	0	0	0.75	0
3631_OG5_139419_7 - FUNGI_YNL058C	YNL058C	YNL058C - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YNL058C is not an essential gene	1	0	0	0	0	0	0.75	0
3632_OG5_139423_7 - FUNGI_YCL029C	YCL029C	"BIK1 - Microtubule-associated protein, component of the interface between microtubules and kinetochore, involved in sister chromatid separation; essential in polyploid cells but not in haploid or diploid cells; ortholog of mammalian CLIP-170"	1	0	0	0	0	0	0.75	0
3633_OG5_139478_7 - FUNGI_YKL006C-A	YKL006C-A	"SFT1 - Intra-Golgi v-SNARE, required for transport of proteins between an early and a later Golgi compartment"	1	0	0	0	0	0	0.75	0
3634_OG5_139483_7 - FUNGI_YDR322C-A	YDR322C-A	"TIM11 - Subunit e of mitochondrial F1F0-ATPase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; essential for the dimeric and oligomeric state of ATP synthase"	1	0	0	0	0	0	0.75	0
3635_OG5_139484_7 - FUNGI_YML081C-A	YML081C-A	"ATP18 - Subunit of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; termed subunit I or subunit j; does not correspond to known ATP synthase subunits in other organisms"	1	0	0	0	0	0	0.75	0
3636_OG5_139486_7 - FUNGI_YKR083C	YKR083C	"DAD2 - Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis"	1	0	0	0	0	0	0.75	0
3637_OG5_140243_7 - FUNGI_YLR423C	YLR423C	ATG17 - Scaffold protein responsible for phagophore assembly site organization; regulatory subunit of an autophagy-specific complex that includes Atg1p and Atg13p; stimulates Atg1p kinase activity	1	0	0	0	0	0	0.75	0
3638_OG5_140275_7 - FUNGI_YOR118W	YOR118W	RTC5 - Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; null mutation suppresses cdc13-1 temperature sensitivity	1	0	0	0	0	0	0.75	0
3639_OG5_136111_7 - FUNGI_YHL009C	YHL009C	YAP3 - Basic leucine zipper (bZIP) transcription factor	1	0	0	0.125	0.095238095	0	0.75	0.0625
3640_OG5_134531_7 - FUNGI_YBR015C	YBR015C	"MNN2 - Alpha-1,2-mannosyltransferase, responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment"	1	0	0	0.125	0.047619048	0	0.75	0
3641_OG5_137324_7 - FUNGI_YKL155C	YKL155C	RSM22 - Mitochondrial ribosomal protein of the small subunit; also predicted to be an S-adenosylmethionine-dependent methyltransferase	1	0	0	0.125	0.047619048	0	0.75	0
3642_OG5_134007_7 - FUNGI_YKL070W	YKL070W	"YKL070W - Putative protein of unknown function; expression induced in cells treated with mycotoxins patulin or citrinin; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"	1	0	0.138888889	0	0.047619048	0	0.75	0.0625
3643_OG5_136794_7 - FUNGI_YML027W	YML027W	"YOX1 - Homeodomain-containing transcriptional repressor, binds to Mcm1p and to early cell cycle boxes (ECBs) in the promoters of cell cycle-regulated genes expressed in M/G1 phase; expression is cell cycle-regulated; potential Cdc28p substrate"	1	0	0	0	0.047619048	0.071428571	0.75	0.0625
3644_OG5_138645_7 - FUNGI_YCR086W	YCR086W	CSM1 - Nucleolar protein that forms a complex with Lrs4p and then Mam1p at kinetochores during meiosis I to mediate accurate homolog segregation; required for condensin recruitment to the replication fork barrier site and rDNA repeat segregation	1	0	0	0.125	0	0	0.75	0
3645_OG5_138678_7 - FUNGI_YML076C	YML076C	"WAR1 - Homodimeric Zn2Cys6 zinc finger transcription factor; binds to a weak acid response element to induce transcription of PDR12 and FUN34, encoding an acid transporter and a putative ammonia transporter, respectively"	1	0	0	0.125	0	0	0.75	0
3646_OG5_135286_7 - FUNGI_YER116C	YER116C	SLX8 - Subunit of the Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex; stimulated by prior attachment of SUMO to the substrate; contains a C-terminal RING domain	1	0	0	0.125	0.142857143	0.142857143	0.7	0
3647_OG5_138628_7 - FUNGI_YJR067C	YJR067C	"YAE1 - Protein of unknown function, essential for growth under standard (aerobic) conditions but not under anaerobic conditions"	1	0	0	0	0.095238095	0	0.7	0
3648_OG5_135112_7 - FUNGI_YJR061W	YJR061W	"YJR061W - Putative protein of unknown function; non-essential gene with similarity to Mnn4, a putative membrane protein involved in glycosylation; transcription repressed by Rm101p"	1	0	0	0	0	0.071428571	0.7	0
3649_OG5_135112_7 - FUNGI_YKL201C	YKL201C	"MNN4 - Putative positive regulator of mannosylphosphate transferase (Mnn6p), involved in mannosylphosphorylation of N-linked oligosaccharides; expression increases in late-logarithmic and stationary growth phases"	1	0	0	0	0	0.071428571	0.7	0
3650_OG5_136362_7 - FUNGI_YKR018C	YKR018C	YKR018C - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus	1	0	0	0	0	0.071428571	0.7	0
3651_OG5_136362_7 - FUNGI_YJL082W	YJL082W	"IML2 - Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"	1	0	0	0	0	0.071428571	0.7	0
3652_OG5_139133_7 - FUNGI_YGL045W	YGL045W	RIM8 - Protein involved in proteolytic activation of Rim101p in response to alkaline pH; interacts with ESCRT-1 subunits Stp22p and Vps28p; essential for anaerobic growth; member of the arrestin-related trafficking adaptor family	1	0	0	0	0	0.071428571	0.7	0
3653_OG5_137424_7 - FUNGI_YGR111W	YGR111W	YGR111W - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus	1	0	0	0	0.047619048	0	0.7	0.0625
3654_OG5_139308_7 - FUNGI_YBR056W	YBR056W	YBR056W - Putative cytoplasmic protein of unknown function	1	0	0	0	0.047619048	0	0.7	0
3655_OG5_139362_7 - FUNGI_YDR231C	YDR231C	"COX20 - Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase"	1	0	0	0	0.047619048	0	0.7	0
3656_OG5_136118_7 - FUNGI_YHR048W	YHR048W	YHK8 - Presumed antiporter of the DHA1 family of multidrug resistance transporters; contains 12 predicted transmembrane spans; expression of gene is up-regulated in cells exhibiting reduced susceptibility to azoles	1	0	0	0	0	0	0.7	0
3657_OG5_136547_7 - FUNGI_YBR162C	YBR162C	"TOS1 - Covalently-bound cell wall protein of unknown function; identified as a cell cycle regulated SBF target gene; deletion mutants are highly resistant to treatment with beta-1,3-glucanase; has sequence similarity to YJL171C"	1	0	0	0	0	0	0.7	0.0625
3658_OG5_136562_7 - FUNGI_YIL079C	YIL079C	"AIR1 - Zinc knuckle protein, involved in nuclear RNA processing and degradation as a component of the TRAMP complex; stimulates the poly(A) polymerase activity of Pap2p in vitro; functionally redundant with Air2p"	1	0	0	0	0	0	0.7	0.125
3659_OG5_136562_7 - FUNGI_YDL175C	YDL175C	"AIR2 - Zinc knuckle protein, involved in nuclear RNA processing and degredation as a component of the TRAMP complex; stimulates the poly(A) polymerase activity of Pap2p in vitro; functionally redundant with Air1p"	1	0	0	0	0	0	0.7	0.125
3660_OG5_136970_7 - FUNGI_YDL049C	YDL049C	"KNH1 - Protein with similarity to Kre9p, which is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant; required for propionic acid resistance"	1	0	0	0	0	0	0.7	0
3661_OG5_136970_7 - FUNGI_YJL174W	YJL174W	"KRE9 - Glycoprotein involved in cell wall beta-glucan assembly; null mutation leads to severe growth defects, aberrant multibudded morphology, and mating defects"	1	0	0	0	0	0	0.7	0
3662_OG5_137004_7 - FUNGI_YOR351C	YOR351C	"MEK1 - Meiosis-specific serine/threonine protein kinase, functions in meiotic checkpoint, promotes recombination between homologous chromosomes by suppressing double strand break repair between sister chromatids"	1	0	0	0	0	0	0.7	0.0625
3663_OG5_137019_7 - FUNGI_YMR215W	YMR215W	"GAS3 - Low abundance, possibly inactive member of the GAS family of GPI-containing proteins; putative 1,3-beta-glucanosyltransferase with similarity to other GAS family members; localizes to the cell wall; mRNA induced during sporulation"	1	0	0	0	0	0	0.7	0
3664_OG5_137019_7 - FUNGI_YOL132W	YOL132W	"GAS4 - 1,3-beta-glucanosyltransferase, involved with Gas2p in spore wall assembly; has similarity to Gas1p; localizes to the cell wall"	1	0	0	0	0	0	0.7	0
3665_OG5_137937_7 - FUNGI_YFL014W	YFL014W	"HSP12 - Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; regulated by HOG and Ras-Pka pathways"	1	0	0	0	0	0	0.7	0
3666_OG5_138652_7 - FUNGI_YOR008C	YOR008C	SLG1 - Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway; involved in maintenance of cell wall integrity; required for mitophagy; involved in organization of the actin cytoskeleton; secretory pathway Wsc1p is required for the arrest of secretion response	1	0	0	0	0	0	0.7	0
3667_OG5_139403_7 - FUNGI_YIL085C	YIL085C	KTR7 - Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family	1	0	0	0	0	0	0.7	0
3668_OG5_139403_7 - FUNGI_YNL029C	YNL029C	KTR5 - Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family	1	0	0	0	0	0	0.7	0
3669_OG5_139424_7 - FUNGI_YHR105W	YHR105W	YPT35 - Endosomal protein of unknown function that contains a phox (PX) homology domain and binds to both phosphatidylinositol-3-phosphate (PtdIns(3)P) and proteins involved in ER-Golgi or vesicular transport	1	0	0	0	0	0	0.7	0
3670_OG5_139442_7 - FUNGI_YFL034C-B	YFL034C-B	"MOB2 - Component of the RAM signaling network, that activates the Cbk1p kinase, thereby facilitating the Ace2p-dependent daughter cell-specific transcription of genes involved in cell separation; similar to Mob1p"	1	0	0	0	0	0	0.7	0.0625
3671_OG5_139490_7 - FUNGI_YGR008C	YGR008C	STF2 - Protein involved in regulation of the mitochondrial F1F0-ATP synthase; Stf1p and Stf2p may act as stabilizing factors that enhance inhibitory action of the Inh1p protein	1	0	0	0	0	0	0.7	0
3672_OG5_139490_7 - FUNGI_YLR327C	YLR327C	TMA10 - Protein of unknown function that associates with ribosomes; putative homolog of the F1F0-ATPase synthase regulator Stf2p	1	0	0	0	0	0	0.7	0
3673_OG5_140228_7 - FUNGI_YBR022W	YBR022W	"POA1 - Phosphatase that is highly specific for ADP-ribose 1''-phosphate, a tRNA splicing metabolite; may have a role in regulation of tRNA splicing"	1	0	0	0	0	0	0.7	0
3674_OG5_140237_7 - FUNGI_YDR306C	YDR306C	YDR306C - F-box protein of unknown function; interacts with Sgt1p via a Leucine-Rich Repeat (LRR) domain	1	0	0	0	0	0	0.7	0
3675_OG5_140241_7 - FUNGI_YLR439W	YLR439W	"MRPL4 - Mitochondrial ribosomal protein of the large subunit, homolog of prokaryotic L29 ribosomal protein; located at the ribosomal tunnel exit"	1	0	0	0	0	0	0.7	0
3676_OG5_140258_7 - FUNGI_YJR141W	YJR141W	YJR141W - Essential protein of unknown function	1	0	0	0	0	0	0.7	0
3677_OG5_140274_7 - FUNGI_YOL054W	YOL054W	PSH1 - E3 ubiquitin ligase that mediates poyubiquitination and degradation of centromere-binding protein Cse4p and prevents Cse4p from mislocalizing to euchromatin; ubiquitylation of Cse4p may be antagonized by Scm3p	1	0	0	0	0	0	0.7	0
3678_OG5_140289_7 - FUNGI_YAL059W	YAL059W	ECM1 - Pre-ribosomal factor involved in 60S ribosomal protein subunit export; associates with the pre-60S particle; shuttles between the nucleus and cytoplasm	1	0	0	0	0	0	0.7	0
3679_OG5_140295_7 - FUNGI_YPL173W	YPL173W	MRPL40 - Mitochondrial ribosomal protein of the large subunit	1	0	0	0	0	0	0.7	0
3680_OG5_140380_7 - FUNGI_YBR233W-A	YBR233W-A	"DAD3 - Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis"	1	0	0	0	0	0	0.7	0
3681_OG5_140382_7 - FUNGI_YMR209C	YMR209C	YMR209C - Putative S-adenosylmethionine-dependent methyltransferase; YMR209C is not an essential gene	1	0	0	0	0	0	0.7	0
3682_OG5_140384_7 - FUNGI_YJL062W-A	YJL062W-A	"COA3 - Mitochondrial inner membrane protein that participates in regulation of COX1 translation, Cox1p stabilization, and cytochrome oxidase assembly"	1	0	0	0	0	0	0.7	0
3683_OG5_141377_7 - FUNGI_YBL043W	YBL043W	ECM13 - Non-essential protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation	1	0	0	0	0	0	0.7	0
3684_OG5_141395_7 - FUNGI_YLR099W-A	YLR099W-A	YLR099W-A - Putative protein of unknown function	1	0	0	0	0	0	0.7	0
3685_OG5_141818_7 - FUNGI_YBL029C-A	YBL029C-A	YBL029C-A - Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; has potential orthologs in Saccharomyces species and in Yarrowia lipolytica	1	0	0	0	0	0	0.7	0
3686_OG5_138306_7 - FUNGI_YBR062C	YBR062C	YBR062C - Protein of unknown function that interacts with Msb2p; may play a role in activation of the filamentous growth pathway.	1	0	0	0.125	0.047619048	0	0.7	0
3687_OG5_137402_7 - FUNGI_YDR428C	YDR428C	"BNA7 - Formylkynurenine formamidase, involved in the de novo biosynthesis of NAD from tryptophan via kynurenine"	1	0	0.027777778	0	0.047619048	0	0.7	0
3688_OG5_138627_7 - FUNGI_YBR215W	YBR215W	"HPC2 - Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; mutants display synthetic defects with subunits of FACT, a complex that allows passage of RNA Pol II through nucleosomes"	1	0	0	0	0.047619048	0.071428571	0.7	0
3689_OG5_138681_7 - FUNGI_YGL028C	YGL028C	SCW11 - Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on its regulation by Ste12p	1	0	0	0.125	0	0	0.7	0
3690_OG5_139360_7 - FUNGI_YMR265C	YMR265C	YMR265C - Putative protein of unknown function	1	0	0	0	0.095238095	0	0.65	0
3691_OG5_134277_7 - FUNGI_YAL067C	YAL067C	"SEO1 - Putative permease, member of the allantoate transporter subfamily of the major facilitator superfamily; mutation confers resistance to ethionine sulfoxide"	1	0	0	0	0.047619048	0	0.65	0
3692_OG5_134277_7 - FUNGI_YGR065C	YGR065C	VHT1 - High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin	1	0	0	0	0.047619048	0	0.65	0
3693_OG5_137721_7 - FUNGI_YMR285C	YMR285C	NGL2 - Protein involved in 5.8S rRNA processing; Ccr4p-like RNase required for correct 3'-end formation of 5.8S rRNA at site E; similar to Ngl1p and Ngl3p	1	0	0	0	0.047619048	0	0.65	0.0625
3694_OG5_137721_7 - FUNGI_YML118W	YML118W	"NGL3 - Putative endonuclease, has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p and Ngl2p"	1	0	0	0	0.047619048	0	0.65	0.0625
3695_OG5_138638_7 - FUNGI_YPL176C	YPL176C	TRE1 - Plasma membrane protein that binds to Bsd2p and regulates ubiquitylation and vacuolar degradation of the metal transporter Smf1p; function is redundant with that of Tre2p; has similarity to transferrin receptors	1	0	0	0	0.047619048	0	0.65	0
3696_OG5_138638_7 - FUNGI_YOR256C	YOR256C	TRE2 - Protein that functions with Tre1p to regulate ubiquitylation and vacuolar degradation of the metal transporter Smf1p; has similarity to transferrin receptors; inviability of null mutant in systematic studies is due to proximity to CDC31	1	0	0	0	0.047619048	0	0.65	0
3697_OG5_134797_7 - FUNGI_YNR055C	YNR055C	HOL1 - Putative transporter in the major facilitator superfamily (DHA1 family) of multidrug resistance transporters; mutations in membrane-spanning domains permit cation and histidinol uptake	1	0	0	0	0	0	0.65	0
3698_OG5_136110_7 - FUNGI_YDL222C	YDL222C	FMP45 - Integral membrane protein localized to mitochondria (untagged protein); required for sporulation and maintaining sphingolipid content; has sequence similarity to SUR7 and YNL194C	1	0	0	0	0	0	0.65	0
3699_OG5_136110_7 - FUNGI_YML052W	YML052W	"SUR7 - Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants"	1	0	0	0	0	0	0.65	0
3700_OG5_136110_7 - FUNGI_YNL194C	YNL194C	YNL194C - Integral membrane protein required for sporulation and plasma membrane sphingolipid content; has sequence similarity to SUR7 and FMP45; GFP-fusion protein is induced in response to the DNA-damaging agent MMS	1	0	0	0	0	0	0.65	0
3701_OG5_139372_7 - FUNGI_YDR514C	YDR514C	YDR514C - Putative protein of unknown function	1	0	0	0	0	0	0.65	0
3702_OG5_139372_7 - FUNGI_YCL036W	YCL036W	"GFD2 - Protein of unknown function, identified as a high-copy suppressor of a dbp5 mutation"	1	0	0	0	0	0	0.65	0
3703_OG5_140037_7 - FUNGI_YOL152W	YOL152W	FRE7 - Putative ferric reductase with similarity to Fre2p; expression induced by low copper levels	1	0	0	0	0	0	0.65	0
3704_OG5_140385_7 - FUNGI_YPR063C	YPR063C	YPR063C - ER-localized protein of unknown function	1	0	0	0	0	0	0.65	0
3705_OG5_141353_7 - FUNGI_YDR476C	YDR476C	YDR476C - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDR476C is not an essential gene	1	0	0	0	0	0	0.65	0
3706_OG5_141391_7 - FUNGI_YJR111C	YJR111C	YJR111C - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondria	1	0	0	0	0	0	0.65	0
3707_OG5_141415_7 - FUNGI_YBR199W	YBR199W	KTR4 - Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family	1	0	0	0	0	0	0.65	0
3708_OG5_141441_7 - FUNGI_YER113C	YER113C	TMN3 - Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn2p; member of Transmembrane Nine family with 9 transmembrane segments; localizes to Golgi; induced by 8-methoxypsoralen plus UVA irradiation	1	0	0	0	0	0	0.65	0
3709_OG5_141863_7 - FUNGI_YDR229W	YDR229W	"IVY1 - Phospholipid-binding protein that interacts with both Ypt7p and Vps33p, may partially counteract the action of Vps33p and vice versa, localizes to the rim of the vacuole as cells approach stationary phase"	1	0	0	0	0	0	0.65	0
3710_OG5_142640_7 - FUNGI_YIL112W	YIL112W	"HOS4 - Subunit of the Set3 complex, which is a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; potential Cdc28p substrate"	1	0	0	0	0	0	0.65	0
3711_OG5_142749_7 - FUNGI_YPL070W	YPL070W	MUK1 - Cytoplasmic protein of unknown function containing a Vps9 domain; computational analysis of large-scale protein-protein interaction data suggests a possible role in transcriptional regulation	1	0	0	0	0	0	0.65	0
3712_OG5_142811_7 - FUNGI_YHL020C	YHL020C	OPI1 - Transcriptional regulator of a variety of genes; phosphorylation by protein kinase A stimulates Opi1p function in negative regulation of phospholipid biosynthetic genes; involved in telomere maintenance	1	0	0	0	0	0	0.65	0
3713_OG5_142971_7 - FUNGI_YDR320C-A	YDR320C-A	"DAD4 - Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis"	1	0	0	0	0	0	0.65	0
3714_OG5_137716_7 - FUNGI_YLR335W	YLR335W	"NUP2 - Nucleoporin involved in nucleocytoplasmic transport, binds to either the nucleoplasmic or cytoplasmic faces of the nuclear pore complex depending on Ran-GTP levels; also has a role in chromatin organization"	1	0	0	0.125	0.095238095	0	0.65	0
3715_OG5_136917_7 - FUNGI_YGL252C	YGL252C	"RTG2 - Sensor of mitochondrial dysfunction; regulates the subcellular location of Rtg1p and Rtg3p, transcriptional activators of the retrograde (RTG) and TOR pathways; Rtg2p is inhibited by the phosphorylated form of Mks1p"	1	0	0.111111111	0	0	0	0.6	0
3716_OG5_137281_7 - FUNGI_YDR144C	YDR144C	"MKC7 - GPI-anchored aspartyl protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; shares functions with Yap3p and Kex2p"	1	0	0	0	0.095238095	0	0.6	0
3717_OG5_137281_7 - FUNGI_YLR120C	YLR120C	"YPS1 - Aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor"	1	0	0	0	0.095238095	0	0.6	0
3718_OG5_139112_7 - FUNGI_YMR173W	YMR173W	"DDR48 - DNA damage-responsive protein, expression is increased in response to heat-shock stress or treatments that produce DNA lesions; contains multiple repeats of the amino acid sequence NNNDSYGS"	1	0	0	0	0.095238095	0	0.6	0.0625
3719_OG5_139377_7 - FUNGI_YDR403W	YDR403W	"DIT1 - Sporulation-specific enzyme required for spore wall maturation, involved in the production of a soluble LL-dityrosine-containing precursor of the spore wall; transcripts accumulate at the time of prospore enclosure"	1	0	0.083333333	0	0	0	0.6	0
3720_OG5_140991_7 - FUNGI_YHR207C	YHR207C	"SET5 - Zinc-finger protein of unknown function, contains one canonical and two unusual fingers in unusual arrangements; deletion enhances replication of positive-strand RNA virus"	1	0	0	0	0.047619048	0	0.6	0
3721_OG5_130378_7 - FUNGI_YLR121C	YLR121C	"YPS3 - Aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor"	1	0	0	0	0	0	0.6	0
3722_OG5_137934_7 - FUNGI_YLR237W	YLR237W	"THI7 - Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia"	1	0	0	0	0	0	0.6	0
3723_OG5_137934_7 - FUNGI_YOR071C	YOR071C	NRT1 - High-affinity nicotinamide riboside transporter; also transports thiamine with low affinity; shares sequence similarity with Thi7p and Thi72p; proposed to be involved in 5-fluorocytosine sensitivity	1	0	0	0	0	0	0.6	0
3724_OG5_137934_7 - FUNGI_YOR192C	YOR192C	THI72 - Transporter of thiamine or related compound; shares sequence similarity with Thi7p	1	0	0	0	0	0	0.6	0
3725_OG5_138083_7 - FUNGI_YNL095C	YNL095C	YNL095C - Putative protein of unknown function predicted to contain a transmembrane domain; YNL095C is not an essential gene	1	0	0	0	0	0	0.6	0
3726_OG5_138083_7 - FUNGI_YLR152C	YLR152C	YLR152C - Putative protein of unknown function; YLR152C is not an essential gene	1	0	0	0	0	0	0.6	0
3727_OG5_138083_7 - FUNGI_YOR092W	YOR092W	ECM3 - Non-essential protein of unknown function; involved in signal transduction and the genotoxic response; induced rapidly in response to treatment with 8-methoxypsoralen and UVA irradiation	1	0	0	0	0	0	0.6	0
3728_OG5_138584_7 - FUNGI_YNL335W	YNL335W	DDI3 - Protein of unknown function; expression is induced over 100-fold by DNA damage; induction decreased in rad6 and rad18 mutants	1	0	0	0	0	0	0.6	0
3729_OG5_138584_7 - FUNGI_YFL061W	YFL061W	DDI2 - Protein of unknown function; expression is induced over 100-fold by DNA damage; induction decreased in rad6 and rad18 mutants	1	0	0	0	0	0	0.6	0
3730_OG5_138591_7 - FUNGI_YGR263C	YGR263C	SAY1 - Sterol deacetylase; component of the sterol acetylation/deacetylation cycle along with Atf2p; integral membrane protein with active site in the ER lumen; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum	1	0	0	0	0	0	0.6	0
3731_OG5_140306_7 - FUNGI_YOR320C	YOR320C	GNT1 - N-acetylglucosaminyltransferase capable of modification of N-linked glycans in the Golgi apparatus	1	0	0	0	0	0	0.6	0
3732_OG5_141354_7 - FUNGI_YMR053C	YMR053C	STB2 - Protein that interacts with Sin3p in a two-hybrid assay and is part of a large protein complex with Sin3p and Stb1p	1	0	0	0	0	0	0.6	0
3733_OG5_141354_7 - FUNGI_YKL072W	YKL072W	STB6 - Protein that binds Sin3p in a two-hybrid assay	1	0	0	0	0	0	0.6	0
3734_OG5_141427_7 - FUNGI_YOR322C	YOR322C	LDB19 - Protein involved in regulating the endocytosis of plasma membrane proteins by recruiting the ubiquitin ligase Rsp5p to its target; localization changes in response to nutrient levels; null mutant has reduced affinity for alcian blue dye	1	0	0	0	0	0	0.6	0
3735_OG5_141450_7 - FUNGI_YML099C	YML099C	"ARG81 - Zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type, involved in the regulation of arginine-responsive genes; acts with Arg80p and Arg82p"	1	0	0	0	0	0	0.6	0
3736_OG5_142541_7 - FUNGI_YFL055W	YFL055W	"AGP3 - Low-affinity amino acid permease, may act to supply the cell with amino acids as nitrogen source in nitrogen-poor conditions; transcription is induced under conditions of sulfur limitation; plays a role in regulating Ty1 transposition"	1	0	0	0	0	0	0.6	0
3737_OG5_142754_7 - FUNGI_YHR151C	YHR151C	MTC6 - Protein of unknown function; mtc6 is synthetically sick with cdc13-1	1	0	0	0	0	0	0.6	0
3738_OG5_144543_7 - FUNGI_YER150W	YER150W	SPI1 - GPI-anchored cell wall protein involved in weak acid resistance; basal expression requires Msn2p/Msn4p; expression is induced under conditions of stress and during the diauxic shift; similar to Sed1p	1	0	0	0	0	0	0.6	0
3739_OG5_144602_7 - FUNGI_YLR057W	YLR057W	YLR057W - Putative protein of unknown function; YLR050W is not an essential gene	1	0	0	0	0	0	0.6	0
3740_OG5_144620_7 - FUNGI_YPR170W-B	YPR170W-B	"YPR170W-B - Putative protein of unknown function, conserved in fungi; partially overlaps the dubious genes YPR169W-A, YPR170W-A and YRP170C"	1	0	0	0	0	0	0.6	0
3741_OG5_134987_7 - FUNGI_YDR402C	YDR402C	"DIT2 - N-formyltyrosine oxidase, sporulation-specific microsomal enzyme involved in the production of N,N-bisformyl dityrosine required for spore wall maturation, homologous to cytochrome P-450s"	1	0	0	0.125	0.095238095	0	0.6	0
3742_OG5_137229_7 - FUNGI_YCR098C	YCR098C	"GIT1 - Plasma membrane permease, mediates uptake of glycerophosphoinositol and glycerophosphocholine as sources of the nutrients inositol and phosphate; expression and transport rate are regulated by phosphate and inositol availability"	1	0	0.055555556	0	0.047619048	0	0.6	0
3743_OG5_137942_7 - FUNGI_YBR137W	YBR137W	YBR137W - Protein of unknown function; localized to the cytoplasm; binds to Replication Protein A (RPA); also interacts with Sgt2p; YBR137W is not an essential gene	1	0	0.166666667	0	0	0	0.55	0
3744_OG5_141550_7 - FUNGI_YDR313C	YDR313C	"PIB1 - RING-type ubiquitin ligase of the endosomal and vacuolar membranes, binds phosphatidylinositol(3)-phosphate; contains a FYVE finger domain"	1	0	0	0	0.047619048	0	0.55	0.0625
3745_OG5_133773_7 - FUNGI_YBR008C	YBR008C	"FLR1 - Plasma membrane multidrug transporter of the major facilitator superfamily, involved in efflux of fluconazole, diazaborine, benomyl, methotrexate, and other drugs; expression induced in cells treated with the mycotoxin patulin"	1	0	0.027777778	0	0	0	0.55	0
3746_OG5_131285_7 - FUNGI_YPR194C	YPR194C	"OPT2 - Oligopeptide transporter; member of the OPT family, with potential orthologs in S. pombe and C. albicans; also plays a role in formation of mature vacuoles"	1	0	0	0	0	0	0.55	0
3747_OG5_138328_7 - FUNGI_YLR004C	YLR004C	THI73 - Putative plasma membrane permease proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription is altered if mitochondrial dysfunction occurs	1	0	0	0	0	0	0.55	0
3748_OG5_139330_7 - FUNGI_YGL186C	YGL186C	"TPN1 - Plasma membrane pyridoxine (vitamin B6) transporter; member of the purine-cytosine permease subfamily within the major facilitator superfamily; proton symporter with similarity to Fcy21p, Fcy2p, and Fcy22p"	1	0	0	0	0	0	0.55	0
3749_OG5_140254_7 - FUNGI_YPL248C	YPL248C	GAL4 - DNA-binding transcription factor required for the activation of the GAL genes in response to galactose; repressed by Gal80p and activated by Gal3p	1	0	0	0	0	0	0.55	0
3750_OG5_140383_7 - FUNGI_YDR213W	YDR213W	"UPC2 - Sterol regulatory element binding protein, induces transcription of sterol biosynthetic genes and of DAN/TIR gene products; Ecm22p homolog; relocates from intracellular membranes to perinuclear foci on sterol depletion"	1	0	0	0	0	0	0.55	0
3751_OG5_140383_7 - FUNGI_YLR228C	YLR228C	"ECM22 - Sterol regulatory element binding protein, regulates transcription of sterol biosynthetic genes; contains Zn[2]-Cys[6] binuclear cluster; homologous to Upc2p; relocates from intracellular membranes to perinuclear foci on sterol depletion"	1	0	0	0	0	0	0.55	0
3752_OG5_140591_7 - FUNGI_YDL035C	YDL035C	"GPR1 - Plasma membrane G protein coupled receptor (GPCR) that interacts with the heterotrimeric G protein alpha subunit, Gpa2p, and with Plc1p; sensor that integrates nutritional signals with the modulation of cell fate via PKA and cAMP synthesis"	1	0	0	0	0	0	0.55	0
3753_OG5_142791_7 - FUNGI_YOL154W	YOL154W	"ZPS1 - Putative GPI-anchored protein; transcription is induced under low-zinc conditions, as mediated by the Zap1p transcription factor, and at alkaline pH"	1	0	0	0	0	0	0.55	0
3754_OG5_142827_7 - FUNGI_YHR178W	YHR178W	"STB5 - Transcription factor, involved in regulating multidrug resistance and oxidative stress response; forms a heterodimer with Pdr1p; contains a Zn(II)2Cys6 zinc finger domain that interacts with a pleiotropic drug resistance element in vitro"	1	0	0	0	0	0	0.55	0
3755_OG5_142841_7 - FUNGI_YNR061C	YNR061C	YNR061C - Putative protein of unknown function	1	0	0	0	0	0	0.55	0
3756_OG5_144217_7 - FUNGI_YPL126W	YPL126W	"NAN1 - U3 snoRNP protein, component of the small (ribosomal) subunit (SSU) processosome containing U3 snoRNA; required for the biogenesis of18S rRNA"	1	0	0	0	0	0	0.55	0
3757_OG5_144425_7 - FUNGI_YNL122C	YNL122C	YNL122C - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL122C is not an essential gene	1	0	0	0	0	0	0.55	0
3758_OG5_144498_7 - FUNGI_YER080W	YER080W	"AIM9 - Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss"	1	0	0	0	0	0	0.55	0
3759_OG5_144512_7 - FUNGI_YGL213C	YGL213C	"SKI8 - Ski complex component and WD-repeat protein, mediates 3'-5' RNA degradation by the cytoplasmic exosome; also required for meiotic double-strand break recombination; null mutants have superkiller phenotype"	1	0	0	0	0	0	0.55	0
3760_OG5_144544_7 - FUNGI_YLR278C	YLR278C	YLR278C - Zinc-cluster protein; GFP-fusion protein localizes to the nucleus; mutant shows moderate growth defect on caffeine; has a prion-domain like fragment that increases frequency of [URE3]; YLR278C is not an essential gene	1	0	0	0	0	0	0.55	0
3761_OG5_144684_7 - FUNGI_YOR166C	YOR166C	"SWT1 - RNA endoribonuclease involved in perinuclear mRNP quality control via the turnover of aberrant, unprocessed pre-mRNAs; interacts with subunits of THO/TREX, TREX-2, and RNA polymerase II; contains a PIN (PilT N terminus) domain"	1	0	0	0	0	0	0.55	0
3762_OG5_144814_7 - FUNGI_YBR162W-A	YBR162W-A	YSY6 - Protein whose expression suppresses a secretory pathway mutation in E. coli; has similarity to the mammalian RAMP4 protein involved in secretion	1	0	0	0	0	0	0.55	0
3763_OG5_144817_7 - FUNGI_YOR080W	YOR080W	"DIA2 - Origin-binding F-box protein that forms an SCF ubiquitin ligase complex with Skp1p and Cdc53p; plays a role in DNA replication, involved in invasive and pseudohyphal growth"	1	0	0	0	0	0	0.55	0
3764_OG5_144995_7 - FUNGI_YCR015C	YCR015C	YCR015C - Putative protein of unknown function; YCR015C is not an essential gene	1	0	0	0	0	0	0.55	0
3765_OG5_145220_7 - FUNGI_YDL063C	YDL063C	YDL063C - Protein required for biogenesis of the large ribosomal subunit; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus	1	0	0	0	0	0	0.55	0
3766_OG5_146850_7 - FUNGI_YKL167C	YKL167C	"MRP49 - Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation"	1	0	0	0	0	0	0.55	0
3767_OG5_146860_7 - FUNGI_YJR098C	YJR098C	"YJR098C - Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"	1	0	0	0	0	0	0.55	0
3768_OG5_133138_7 - FUNGI_YIR042C	YIR042C	YIR042C - Putative protein of unknown function; YIR042C is a non-essential gene	1	0	0.333333333	0.125	0.19047619	0	0.55	0.0625
3769_OG5_139633_7 - FUNGI_YHL024W	YHL024W	RIM4 - Putative RNA-binding protein required for the expression of early and middle sporulation genes	1	0	0	0.125	0.047619048	0	0.55	0
3770_OG5_140009_7 - FUNGI_YNL283C	YNL283C	WSC2 - Partially redundant sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway involved in maintenance of cell wall integrity and recovery from heat shock; secretory pathway Wsc2p is required for the arrest of secretion response	1	0	0	0.125	0	0	0.55	0.0625
3771_OG5_140009_7 - FUNGI_YOL105C	YOL105C	"WSC3 - Partially redundant sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway involved in maintenance of cell wall integrity; involved in the response to heat shock and other stressors; regulates 1,3-beta-glucan synthesis"	1	0	0	0.125	0	0	0.55	0.0625
3772_OG5_138309_7 - FUNGI_YDL002C	YDL002C	"NHP10 - Protein related to mammalian high mobility group proteins; preferentially binds DNA ends, protecting them from exonucleatic cleavage; likely component of the chromatin-remodeling complex INO80 complex; proposed to be involved in DNA repair"	1	0	0	0.125	0.142857143	0.071428571	0.5	0
3773_OG5_133137_7 - FUNGI_YCL026C-B	YCL026C-B	HBN1 - Putative protein of unknown function; similar to bacterial nitroreductases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; protein becomes insoluble upon intracellular iron depletion	1	0	0.166666667	0	0	0	0.5	0.125
3774_OG5_133137_7 - FUNGI_YCL026C-A	YCL026C-A	"FRM2 - Protein of unknown function, involved in the integration of lipid signaling pathways with cellular homeostasis; expression induced in cells treated with the mycotoxin patulin; has similarity to bacterial nitroreductases"	1	0	0.166666667	0	0	0	0.5	0.125
3775_OG5_143297_7 - FUNGI_YHR131C	YHR131C	YHR131C - Putative protein of unknown function; GFP-fusion protein localizes to the cytoplasm; overexpression causes cell cycle delay or arrest; contains a PH domain and binds phosphatidylinositols and other lipids in a large-scale study	1	0	0	0	0	0.071428571	0.5	0
3776_OG5_143297_7 - FUNGI_YNL144C	YNL144C	YNL144C - Putative protein of unknown function; non-tagged protein is detected in highly purified mitochondria in high-throughput studies; contains a PH domain and binds phosphatidylinositols and phosphatidylethanolamine in a large-scale study	1	0	0	0	0	0.071428571	0.5	0
3777_OG5_136065_7 - FUNGI_YDL243C	YDL243C	AAD4 - Putative aryl-alcohol dehydrogenase; involved in oxidative stress response; similar to P. chrysosporium aryl-alcohol dehydrogenase; expression induced in cells treated with the mycotoxin patulin	1	0	0.027777778	0	0	0	0.5	0
3778_OG5_136065_7 - FUNGI_YCR107W	YCR107W	AAD3 - Putative aryl-alcohol dehydrogenase; similar to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role	1	0	0.027777778	0	0	0	0.5	0
3779_OG5_136065_7 - FUNGI_YNL331C	YNL331C	AAD14 - Putative aryl-alcohol dehydrogenase; similar to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role	1	0	0.027777778	0	0	0	0.5	0
3780_OG5_144801_7 - FUNGI_YNL056W	YNL056W	OCA2 - Putative protein with similarity to predicted tyrosine phosphatases Oca1p and Siw14p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL056W is not an essential gene	1	0	0.027777778	0	0	0	0.5	0
3781_OG5_141423_7 - FUNGI_YLL055W	YLL055W	YCT1 - High-affinity cysteine-specific transporter with similarity to the Dal5p family of transporters; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YCT1 is not an essential gene	1	0	0	0	0	0	0.5	0
3782_OG5_144653_7 - FUNGI_YLR390W-A	YLR390W-A	"CCW14 - Covalently linked cell wall glycoprotein, present in the inner layer of the cell wall"	1	0	0	0	0	0	0.5	0.0625
3783_OG5_144657_7 - FUNGI_YKL015W	YKL015W	"PUT3 - Transcriptional activator of proline utilization genes, constitutively binds PUT1 and PUT2 promoter sequences and undergoes a conformational change to form the active state; has a Zn(2)-Cys(6) binuclear cluster domain"	1	0	0	0	0	0	0.5	0
3784_OG5_146773_7 - FUNGI_YMR225C	YMR225C	MRPL44 - Mitochondrial ribosomal protein of the large subunit	1	0	0	0	0	0	0.5	0
3785_OG5_146802_7 - FUNGI_YBR180W	YBR180W	"DTR1 - Putative dityrosine transporter, required for spore wall synthesis; expressed during sporulation; member of the major facilitator superfamily (DHA1 family) of multidrug resistance transporters"	1	0	0	0	0	0	0.5	0
3786_OG5_147020_7 - FUNGI_YOL077W-A	YOL077W-A	"ATP19 - Subunit k of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; associated only with the dimeric form of ATP synthase"	1	0	0	0	0	0	0.5	0
3787_OG5_147572_7 - FUNGI_YLR221C	YLR221C	"RSA3 - Protein with a likely role in ribosomal maturation, required for accumulation of wild-type levels of large (60S) ribosomal subunits; binds to the helicase Dbp6p in pre-60S ribosomal particles in the nucleolus"	1	0	0	0	0	0	0.5	0
3788_OG5_147577_7 - FUNGI_YPL121C	YPL121C	"MEI5 - Meiosis specific protein involved in DMC1-dependent meiotic recombination, forms heterodimer with Sae3p; proposed to be an assembly factor for Dmc1p"	1	0	0	0	0	0	0.5	0
3789_OG5_147578_7 - FUNGI_YNL282W	YNL282W	"POP3 - Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs"	1	0	0	0	0	0	0.5	0
3790_OG5_149755_7 - FUNGI_YGL108C	YGL108C	"YGL108C - Protein of unknown function, predicted to be palmitoylated; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery"	1	0	0	0	0	0	0.5	0
3791_OG5_150108_7 - FUNGI_Q0080	Q0080	"ATP8 - Subunit 8 of the F0 sector of mitochondrial inner membrane F1-F0 ATP synthase, encoded on the mitochondrial genome; ATP8 and ATP6 mRNAs are not translated in the absence of the F1 sector of ATPase"	1	0	0	0	0	0	0.5	0
3792_OG5_133790_7 - FUNGI_YNL099C	YNL099C	"OCA1 - Putative protein tyrosine phosphatase, required for cell cycle arrest in response to oxidative damage of DNA"	1	0	0	0.125	0.095238095	0	0.5	0.3125
3793_OG5_144307_7 - FUNGI_YPL190C	YPL190C	NAB3 - Single stranded RNA binding protein; acidic ribonucleoprotein; required for termination of non-poly(A) transcripts and efficient splicing; interacts with Nrd1p	1	0	0	0	0.095238095	0	0.45	0
3794_OG5_146776_7 - FUNGI_YKL108W	YKL108W	"SLD2 - Protein required for DNA replication, phosphorylated in S phase by S-phase cyclin-dependent kinases (Cdks), phosphorylation is essential for DNA replication and for complex formation with Dpb11p; potential Cdc28p substrate"	1	0	0	0	0	0.071428571	0.45	0
3795_OG5_147117_7 - FUNGI_YMR005W	YMR005W	"TAF4 - TFIID subunit (48 kDa), involved in RNA polymerase II transcription initiation; potential Cdc28p substrate"	1	0	0	0	0	0.071428571	0.45	0
3796_OG5_144646_7 - FUNGI_YPL187W	YPL187W	"MF(ALPHA)1 - Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)2, although MF(ALPHA)1 produces most alpha-factor"	1	0	0	0	0.047619048	0	0.45	0
3797_OG5_145141_7 - FUNGI_YLR223C	YLR223C	"IFH1 - Coactivator that regulates transcription of ribosomal protein (RP) genes; recruited to RP gene promoters during optimal growth conditions via Fhl1p; subunit of CURI, a complex that coordinates RP production and pre-rRNA processing"	1	0	0	0	0.047619048	0	0.45	0
3798_OG5_146779_7 - FUNGI_YLR131C	YLR131C	"ACE2 - Transcription factor that activates expression of early G1-specific genes, localizes to daughter cell nuclei after cytokinesis and delays G1 progression in daughters, localization is regulated by phosphorylation"	1	0	0	0	0.047619048	0	0.45	0
3799_OG5_146811_7 - FUNGI_YJR112W	YJR112W	NNF1 - Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; required for accurate chromosome segregation	1	0	0	0	0.047619048	0	0.45	0
3800_OG5_147061_7 - FUNGI_YDR478W	YDR478W	"SNM1 - Subunit of RNase MRP, which cleaves pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; binds to the NME1 RNA subunit of RNase MRP"	1	0	0	0	0.047619048	0	0.45	0
3801_OG5_147558_7 - FUNGI_YAR002W	YAR002W	"NUP60 - Subunit of the nuclear pore complex (NPC), functions to anchor Nup2p to the NPC in a process controlled by the nucleoplasmic concentration of Gsp1p-GTP; involved in nuclear export and cytoplasmic localization of specific mRNAs such as ASH1"	1	0	0	0	0.047619048	0	0.45	0
3802_OG5_149314_7 - FUNGI_YER161C	YER161C	"SPT2 - Protein involved in negative regulation of transcription; required for RNA polyadenylation; exhibits regulated interactions with both histones and SWI-SNF components, has similarity to mammalian HMG1 proteins"	1	0	0	0	0.047619048	0	0.45	0
3803_OG5_144651_7 - FUNGI_YMR065W	YMR065W	"KAR5 - Protein required for nuclear membrane fusion during karyogamy, localizes to the membrane with a soluble portion in the endoplasmic reticulum lumen, may form a complex with Jem1p and Kar2p; expression of the gene is regulated by pheromone"	1	0	0.027777778	0	0	0	0.45	0
3804_OG5_136590_7 - FUNGI_YIL014W	YIL014W	"MNT3 - Alpha-1,3-mannosyltransferase, adds the fourth and fifth alpha-1,3-linked mannose residues to O-linked glycans during protein O-glycosylation"	1	0	0	0	0	0	0.45	0
3805_OG5_136963_7 - FUNGI_YPR196W	YPR196W	YPR196W - Putative maltose activator	1	0	0	0	0	0	0.45	0
3806_OG5_136963_7 - FUNGI_YFL052W	YFL052W	"YFL052W - Putative zinc cluster protein that contains a DNA binding domain; null mutant sensitive to calcofluor white, low osmolarity and heat, suggesting a role for YFL052Wp in cell wall integrity"	1	0	0	0	0	0	0.45	0
3807_OG5_136963_7 - FUNGI_YBR297W	YBR297W	"MAL33 - MAL-activator protein, part of complex locus MAL3; nonfunctional in genomic reference strain S288C"	1	0	0	0	0	0	0.45	0
3808_OG5_136963_7 - FUNGI_YGR288W	YGR288W	"MAL13 - MAL-activator protein, part of complex locus MAL1; nonfunctional in genomic reference strain S288C"	1	0	0	0	0	0	0.45	0
3809_OG5_145224_7 - FUNGI_YGR225W	YGR225W	AMA1 - Activator of meiotic anaphase promoting complex (APC/C); Cdc20p family member; required for initiation of spore wall assembly; required for Clb1p degradation during meiosis	1	0	0	0	0	0	0.45	0
3810_OG5_145226_7 - FUNGI_YJL139C	YJL139C	"YUR1 - Mannosyltransferase of the KTR1 family, involved in protein N-glycosylation; located in the Golgi apparatus"	1	0	0	0	0	0	0.45	0
3811_OG5_145226_7 - FUNGI_YKR061W	YKR061W	KTR2 - Mannosyltransferase involved in N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family	1	0	0	0	0	0	0.45	0
3812_OG5_147569_7 - FUNGI_YGL060W	YGL060W	YBP2 - Central kinetochore associated protein that mediates mitotic progression; interacts with several central kinetochore proteins and the centromeric histone Cse4p; role in resistance to oxidative stress; similarity to Ybp1p and Slk19p	1	0	0	0	0	0	0.45	0
3813_OG5_147569_7 - FUNGI_YBR216C	YBR216C	"YBP1 - Protein required for oxidation of specific cysteine residues of the transcription factor Yap1p, resulting in the nuclear localization of Yap1p in response to stress"	1	0	0	0	0	0	0.45	0
3814_OG5_149252_7 - FUNGI_YBR108W	YBR108W	AIM3 - Protein interacting with Rvs167p; null mutant is viable and displays elevated frequency of mitochondrial genome loss	1	0	0	0	0	0	0.45	0
3815_OG5_149541_7 - FUNGI_YPR104C	YPR104C	FHL1 - Regulator of ribosomal protein transcription; has forkhead associated domain that binds phosphorylated proteins; also has forkhead DNA-binding domain but does not bind DNA in vitro; suppresses RNA pol III and splicing factor prp4 mutants	1	0	0	0	0	0	0.45	0
3816_OG5_149589_7 - FUNGI_YJR042W	YJR042W	"NUP85 - Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC), required for assembly of the subcomplex and also for formation of the nucleocytoplasmic Gsp1p concentration gradient that plays a role in nuclear trafficking"	1	0	0	0	0	0	0.45	0
3817_OG5_149737_7 - FUNGI_YGR117C	YGR117C	YGR117C - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	1	0	0	0	0	0	0.45	0
3818_OG5_149749_7 - FUNGI_YHR138C	YHR138C	YHR138C - Putative protein of unknown function; has similarity to Pbi2p; double null mutant lacking Pbi2p and Yhr138p exhibits highly fragmented vacuoles	1	0	0	0	0	0	0.45	0
3819_OG5_149766_7 - FUNGI_YDL020C	YDL020C	RPN4 - Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses	1	0	0	0	0	0	0.45	0
3820_OG5_149785_7 - FUNGI_YGL110C	YGL110C	"CUE3 - Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination"	1	0	0	0	0	0	0.45	0
3821_OG5_149786_7 - FUNGI_YKL119C	YKL119C	"VPH2 - Integral membrane protein required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the endoplasmic reticulum (ER)"	1	0	0	0	0	0	0.45	0
3822_OG5_149829_7 - FUNGI_YMR312W	YMR312W	"ELP6 - Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity"	1	0	0	0	0	0	0.45	0
3823_OG5_149831_7 - FUNGI_YDR318W	YDR318W	"MCM21 - Protein involved in minichromosome maintenance; component of the COMA complex (Ctf19p, Okp1p, Mcm21p, Ame1p) that bridges kinetochore subunits that are in contact with centromeric DNA and the subunits bound to microtubules"	1	0	0	0	0	0	0.45	0
3824_OG5_149837_7 - FUNGI_YDR462W	YDR462W	MRPL28 - Mitochondrial ribosomal protein of the large subunit	1	0	0	0	0	0	0.45	0
3825_OG5_149898_7 - FUNGI_YER182W	YER182W	"FMP10 - Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"	1	0	0	0	0	0	0.45	0
3826_OG5_149901_7 - FUNGI_YPR007C	YPR007C	REC8 - Meiosis-specific component of sister chromatid cohesion complex; maintains cohesion between sister chromatids during meiosis I; maintains cohesion between centromeres of sister chromatids until meiosis II; homolog of S. pombe Rec8p	1	0	0	0	0	0	0.45	0
3827_OG5_149903_7 - FUNGI_YBL028C	YBL028C	YBL028C - Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis	1	0	0	0	0	0	0.45	0
3828_OG5_149905_7 - FUNGI_YGR104C	YGR104C	SRB5 - Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; involved in telomere maintenance	1	0	0	0	0	0	0.45	0
3829_OG5_150114_7 - FUNGI_YNL080C	YNL080C	EOS1 - Protein involved in N-glycosylation; deletion mutation confers sensitivity to exidative stress and shows synthetic lethality with mutations in the spindle checkpoint genes BUB3 and MAD1; YNL080C is not an essential gene	1	0	0	0	0	0	0.45	0
3830_OG5_150125_7 - FUNGI_YDR101C	YDR101C	ARX1 - Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex	1	0	0	0	0	0	0.45	0
3831_OG5_150133_7 - FUNGI_YMR228W	YMR228W	"MTF1 - Mitochondrial RNA polymerase specificity factor with structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors, interacts with mitochondrial core polymerase Rpo41p"	1	0	0	0	0	0	0.45	0
3832_OG5_150618_7 - FUNGI_YLR001C	YLR001C	"YLR001C - Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; predicted to be palmitoylated"	1	0	0	0	0	0	0.45	0
3833_OG5_150687_7 - FUNGI_YML088W	YML088W	"UFO1 - F-box receptor protein, subunit of the Skp1-Cdc53-F-box receptor (SCF) E3 ubiquitin ligase complex; binds to phosphorylated Ho endonuclease, allowing its ubiquitylation by SCF and subsequent degradation"	1	0	0	0	0	0	0.45	0
3834_OG5_150688_7 - FUNGI_YJR118C	YJR118C	ILM1 - Protein of unknown function; may be involved in mitochondrial DNA maintenance; required for slowed DNA synthesis-induced filamentous growth	1	0	0	0	0	0	0.45	0
3835_OG5_150692_7 - FUNGI_YIL087C	YIL087C	"AIM19 - Putative protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays reduced respiratory growth"	1	0	0	0	0	0	0.45	0
3836_OG5_150693_7 - FUNGI_YJL156C	YJL156C	"SSY5 - Serine protease of SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p); contains an inhibitory domain that dissociates in response to extracellular amino acids, freeing a catalytic domain to activate transcription factor Stp1p"	1	0	0	0	0	0	0.45	0
3837_OG5_150695_7 - FUNGI_YFR043C	YFR043C	IRC6 - Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci	1	0	0	0	0	0	0.45	0
3838_OG5_150700_7 - FUNGI_YOR051C	YOR051C	"ETT1 - Nuclear protein that inhibits replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts; deletion increases stop codon readthrough"	1	0	0	0	0	0	0.45	0
3839_OG5_150703_7 - FUNGI_YGR268C	YGR268C	HUA1 - Cytoplasmic protein containing a zinc finger domain with sequence similarity to that of Type I J-proteins; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly	1	0	0	0	0	0	0.45	0
3840_OG5_150705_7 - FUNGI_YBR280C	YBR280C	SAF1 - F-Box protein involved in proteasome-dependent degradation of Aah1p during entry of cells into quiescence; interacts with Skp1	1	0	0	0	0	0	0.45	0
3841_OG5_150708_7 - FUNGI_YOR174W	YOR174W	MED4 - Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation	1	0	0	0	0	0	0.45	0
3842_OG5_152395_7 - FUNGI_YMR003W	YMR003W	AIM34 - Protein of unknown function; GFP-fusion protein localizes to the mitochondria; null mutant is viable and displays reduced frequency of mitochondrial genome loss	1	0	0	0	0	0	0.45	0
3843_OG5_152644_7 - FUNGI_YGR081C	YGR081C	SLX9 - Protein required for pre-rRNA processing; associated with the 90S pre-ribosome and 43S small ribosomal subunit precursor; interacts with U3 snoRNA; deletion mutant has synthetic fitness defect with an sgs1 deletion mutant	1	0	0	0	0	0	0.45	0
3844_OG5_152860_7 - FUNGI_YKL050C	YKL050C	YKL050C - Protein of unknown function; the YKL050W protein is a target of the SCFCdc4 ubiquitin ligase complex and YKL050W transcription is regulated by Azf1p	1	0	0	0	0	0	0.45	0
3845_OG5_142804_7 - FUNGI_YCR067C	YCR067C	SED4 - Integral endoplasmic reticulum membrane protein that stimulates Sar1p GTPase activity; involved in COPII vesicle budding through disassociation of coat proteins from membranes onto liposomes; binds Sec16p; similar to Sec12p	1	0	0	0.125	0	0	0.45	0
3846_OG5_142804_7 - FUNGI_YNR026C	YNR026C	"SEC12 - Guanine nucleotide exchange factor (GEF), activates Sar1p by catalyzing the exchange of GDP for GTP; required for the initiation of COPII vesicle formation in ER to Golgi transport; glycosylated integral membrane protein of the ER"	1	0	0	0.125	0	0	0.45	0
3847_OG5_146720_7 - FUNGI_YNL208W	YNL208W	"YNL208W - Protein of unknown function; may interact with ribosomes, based on co-purification experiments; authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; potential orthologs found in other fungi"	1	0	0	0.125	0	0	0.45	0
3848_OG5_146788_7 - FUNGI_YOR140W	YOR140W	"SFL1 - Transcriptional repressor and activator; involved in repression of flocculation-related genes, and activation of stress responsive genes; negatively regulated by cAMP-dependent protein kinase A subunit Tpk2p"	1	0	0	0.125	0	0	0.45	0
3849_OG5_147023_7 - FUNGI_YNL050C	YNL050C	YNL050C - Putative protein of unknown function; YNL050c is not an essential gene	1	0	0	0.125	0	0	0.45	0
3850_OG5_147398_7 - FUNGI_YGR150C	YGR150C	CCM1 - Mitochondrial 15s rRNA-binding protein; required for intron removal of COB and COX1 pre-mRNAs; contains pentatricopeptide repeat (PPR) motifs; mutant is respiratory deficient and has defective plasma membrane electron transport	1	0	0	0.125	0	0	0.45	0
3851_OG5_135066_7 - FUNGI_YNR044W	YNR044W	"AGA1 - Anchorage subunit of a-agglutinin of a-cells, highly O-glycosylated protein with N-terminal secretion signal and C-terminal signal for addition of GPI anchor to cell wall, linked to adhesion subunit Aga2p via two disulfide bonds"	1	0	0	0.125	0.238095238	0.285714286	0.4	0.125
3852_OG5_141386_7 - FUNGI_YFR016C	YFR016C	YFR016C - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and bud; interacts with Spa2p; YFL016C is not an essential gene	1	0	0	0	0.142857143	0	0.4	0.125
3853_OG5_149943_7 - FUNGI_YEL017W	YEL017W	"GTT3 - Protein of unknown function with a possible role in glutathione metabolism, as suggested by computational analysis of large-scale protein-protein interaction data; GFP-fusion protein localizes to the nuclear periphery"	1	0	0	0	0	0.071428571	0.4	0
3854_OG5_150690_7 - FUNGI_YNR024W	YNR024W	"MPP6 - Nuclear exosome-associated RNA binding protein; involved in surveillance of pre-rRNAs and pre-mRNAs, and the degradation of cryptic non-coding RNAs (ncRNA); copurifies with ribosomes"	1	0	0	0	0	0.071428571	0.4	0
3855_OG5_146292_7 - FUNGI_YPR124W	YPR124W	"CTR1 - High-affinity copper transporter of the plasma membrane, mediates nearly all copper uptake under low copper conditions; transcriptionally induced at low copper levels and degraded at high copper levels"	1	0	0	0	0.047619048	0	0.4	0
3856_OG5_146780_7 - FUNGI_YAL024C	YAL024C	LTE1 - Protein similar to GDP/GTP exchange factors but without detectable GEF activity; required for asymmetric localization of Bfa1p at daughter-directed spindle pole bodies and for mitotic exit at low temperatures	1	0	0	0	0.047619048	0	0.4	0
3857_OG5_149468_7 - FUNGI_YGL098W	YGL098W	"USE1 - Essential SNARE protein localized to the ER, involved in retrograde traffic from the Golgi to the ER; forms a complex with the SNAREs Sec22p, Sec20p and Ufe1p"	1	0	0	0	0.047619048	0	0.4	0
3858_OG5_149500_7 - FUNGI_YJL201W	YJL201W	ECM25 - Non-essential protein of unknown function; promoter contains a consensus binding sequence for factor Abf1p	1	0	0	0	0.047619048	0	0.4	0
3859_OG5_149764_7 - FUNGI_YOL028C	YOL028C	YAP7 - Putative basic leucine zipper (bZIP) transcription factor	1	0	0	0	0.047619048	0	0.4	0.0625
3860_OG5_149792_7 - FUNGI_YJR092W	YJR092W	BUD4 - Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding; potential Cdc28p substrate	1	0	0	0	0.047619048	0	0.4	0
3861_OG5_149794_7 - FUNGI_YKR029C	YKR029C	SET3 - Defining member of the SET3 histone deacetylase complex which is a meiosis-specific repressor of sporulation genes; necessary for efficient transcription by RNAPII; one of two yeast proteins that contains both SET and PHD domains	1	0	0	0	0.047619048	0	0.4	0
3862_OG5_149861_7 - FUNGI_YFL023W	YFL023W	BUD27 - Unconventional prefoldin protein involved in translation initiation; mutants have inappropriate expression of nutrient sensitive genes due to translational derepression of Gcn4p transcription factor; diploid mutants show random budding	1	0	0	0	0.047619048	0	0.4	0
3863_OG5_149984_7 - FUNGI_YGR013W	YGR013W	"SNU71 - Component of U1 snRNP required for mRNA splicing via spliceosome; yeast specific, no metazoan counterpart"	1	0	0	0	0.047619048	0	0.4	0
3864_OG5_150073_7 - FUNGI_YOR144C	YOR144C	ELG1 - Subunit of an alternative replication factor C complex important for DNA replication and genome integrity; suppresses spontaneous DNA damage; involved in homologous recombination-mediated repair and telomere homeostasis	1	0	0	0	0.047619048	0	0.4	0
3865_OG5_150117_7 - FUNGI_YMR126C	YMR126C	"DLT1 - Protein of unknown function, mutant sensitive to 6-azauracil (6AU) and mycophenolic acid (MPA)"	1	0	0	0	0.047619048	0	0.4	0
3866_OG5_150178_7 - FUNGI_YBR255W	YBR255W	"MTC4 - Protein of unknown function, required for normal growth rate at 15 degrees C; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; mtc4 is synthetically sick with cdc13-1"	1	0	0	0	0.047619048	0	0.4	0
3867_OG5_150699_7 - FUNGI_YDL099W	YDL099W	"BUG1 - Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes"	1	0	0.027777778	0	0	0	0.4	0
3868_OG5_136428_7 - FUNGI_YBR195C	YBR195C	"MSI1 - Subunit of chromatin assembly factor I (CAF-1), negative regulator of the RAS/cAMP pathway via sequestration of Npr1p kinase; localizes to the nucleus and cytoplasm; homologous to human retinoblastoma binding proteins RbAp48 and RbAp46"	1	0	0	0	0	0	0.4	0.1875
3869_OG5_140288_7 - FUNGI_YLR098C	YLR098C	"CHA4 - DNA binding transcriptional activator, mediates serine/threonine activation of the catabolic L-serine (L-threonine) deaminase (CHA1); Zinc-finger protein with Zn[2]-Cys[6] fungal-type binuclear cluster domain"	1	0	0	0	0	0	0.4	0
3870_OG5_140288_7 - FUNGI_YOR337W	YOR337W	TEA1 - Ty1 enhancer activator required for full levels of Ty enhancer-mediated transcription; C6 zinc cluster DNA-binding protein	1	0	0	0	0	0	0.4	0
3871_OG5_142737_7 - FUNGI_YOR389W	YOR389W	YOR389W - Putative protein of unknown function; expression regulated by copper levels	1	0	0	0	0	0	0.4	0
3872_OG5_142737_7 - FUNGI_YPL277C	YPL277C	YPL277C - Putative protein of unknown function; localized to the membranes; gene expression regulated by copper levels	1	0	0	0	0	0	0.4	0
3873_OG5_142969_7 - FUNGI_YMR238W	YMR238W	"DFG5 - Putative mannosidase, essential glycosylphosphatidylinositol (GPI)-anchored membrane protein required for cell wall biogenesis in bud formation, involved in filamentous growth, homologous to Dcw1p"	1	0	0	0	0	0	0.4	0
3874_OG5_144645_7 - FUNGI_YHR124W	YHR124W	NDT80 - Meiosis-specific transcription factor required for exit from pachytene and for full meiotic recombination; activates middle sporulation genes; competes with Sum1p for binding to promoters containing middle sporulation elements (MSE)	1	0	0	0	0	0	0.4	0
3875_OG5_145217_7 - FUNGI_YLR110C	YLR110C	"CCW12 - Cell wall mannoprotein with a role in maintenance of newly synthesized areas of cell wall; localizes to periphery of small buds, septum region of larger buds, and shmoo tip"	1	0	0	0	0	0	0.4	0
3876_OG5_145221_7 - FUNGI_YGL139W	YGL139W	"FLC3 - Putative FAD transporter, similar to Flc1p and Flc2p; localized to the ER"	1	0	0	0	0	0	0.4	0
3877_OG5_145221_7 - FUNGI_YPL221W	YPL221W	FLC1 - Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance	1	0	0	0	0	0	0.4	0
3878_OG5_146542_7 - FUNGI_YLR422W	YLR422W	"YLR422W - Protein of unknown function with similarity to human DOCK proteins (guanine nucleotide exchange factors); interacts with Ino4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, YLR422W is not an essential protein"	1	0	0	0	0	0	0.4	0
3879_OG5_146737_7 - FUNGI_YBR295W	YBR295W	"PCA1 - Cadmium transporting P-type ATPase; may also have a role in copper and iron homeostasis; stabilized by Cd binding, which prevents ubiquitination; S288C and other lab strains contain a G970R mutation which eliminates Cd transport function"	1	0	0	0	0	0	0.4	0.0625
3880_OG5_146870_7 - FUNGI_YDL048C	YDL048C	"STP4 - Protein containing a Kruppel-type zinc-finger domain; has similarity to Stp1p, Stp2p, and Stp3p"	1	0	0	0	0	0	0.4	0
3881_OG5_146870_7 - FUNGI_YLR375W	YLR375W	"STP3 - Zinc-finger protein of unknown function, possibly involved in pre-tRNA splicing and in uptake of branched-chain amino acids"	1	0	0	0	0	0	0.4	0
3882_OG5_146950_7 - FUNGI_YHR043C	YHR043C	"DOG2 - 2-deoxyglucose-6-phosphate phosphatase, member of a family of low molecular weight phosphatases, similar to Dog1p, induced by oxidative and osmotic stress, confers 2-deoxyglucose resistance when overexpressed"	1	0	0	0	0	0	0.4	0
3883_OG5_146950_7 - FUNGI_YHR044C	YHR044C	"DOG1 - 2-deoxyglucose-6-phosphate phosphatase, similar to Dog2p, member of a family of low molecular weight phosphatases; confers 2-deoxyglucose resistance when overexpressed, in vivo substrate has not yet been identified"	1	0	0	0	0	0	0.4	0
3884_OG5_147075_7 - FUNGI_YGR165W	YGR165W	MRPS35 - Mitochondrial ribosomal protein of the small subunit	1	0	0	0	0	0	0.4	0
3885_OG5_147189_7 - FUNGI_YIL002C	YIL002C	"INP51 - Phosphatidylinositol 4,5-bisphosphate 5-phosphatase, synaptojanin-like protein with an N-terminal Sac1 domain, plays a role in phosphatidylinositol 4,5-bisphosphate homeostasis and in endocytosis; null mutation confers cold-tolerant growth"	1	0	0	0	0	0	0.4	0.125
3886_OG5_147555_7 - FUNGI_YKR072C	YKR072C	"SIS2 - Negative regulatory subunit of protein phosphatase 1 Ppz1p and also a subunit of the phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis"	1	0	0	0	0	0	0.4	0
3887_OG5_147555_7 - FUNGI_YOR054C	YOR054C	"VHS3 - Negative regulatory subunit of protein phosphatase 1 Ppz1p and also a subunit of the phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis"	1	0	0	0	0	0	0.4	0
3888_OG5_147575_7 - FUNGI_YIL056W	YIL056W	"VHR1 - Transcriptional activator, required for the vitamin H-responsive element (VHRE) mediated induction of VHT1 (Vitamin H transporter) and BIO5 (biotin biosynthesis intermediate transporter) in response to low biotin concentrations"	1	0	0	0	0	0	0.4	0
3889_OG5_147576_7 - FUNGI_YBR197C	YBR197C	YBR197C - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR197C is not an essential gene	1	0	0	0	0	0	0.4	0
3890_OG5_147576_7 - FUNGI_YPL077C	YPL077C	YPL077C - Putative protein of unknown function; regulates PIS1 expression; mutant displays spore wall assembly defect in ether sensitivity screen; YPL077C is not an essential gene	1	0	0	0	0	0	0.4	0
3891_OG5_147581_7 - FUNGI_YIL151C	YIL151C	"YIL151C - Putative protein of unknown function, predicted to contain a PINc domain"	1	0	0	0	0	0	0.4	0
3892_OG5_147581_7 - FUNGI_YKR096W	YKR096W	"YKR096W - Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; predicted to contain a PINc domain"	1	0	0	0	0	0	0.4	0
3893_OG5_147585_7 - FUNGI_YJR059W	YJR059W	PTK2 - Putative serine/threonine protein kinase involved in regulation of ion transport across plasma membrane; enhances spermine uptake	1	0	0	0	0	0	0.4	0
3894_OG5_147585_7 - FUNGI_YKL198C	YKL198C	PTK1 - Putative serine/threonine protein kinase that regulates spermine uptake; involved in polyamine transport; possible mitochondrial protein	1	0	0	0	0	0	0.4	0
3895_OG5_149894_7 - FUNGI_YKR019C	YKR019C	"IRS4 - EH domain-containing protein involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS"	1	0	0	0	0	0	0.4	0
3896_OG5_149894_7 - FUNGI_YJL083W	YJL083W	"TAX4 - EH domain-containing protein involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS"	1	0	0	0	0	0	0.4	0
3897_OG5_149904_7 - FUNGI_YER155C	YER155C	BEM2 - Rho GTPase activating protein (RhoGAP) involved in the control of cytoskeleton organization and cellular morphogenesis; required for bud emergence	1	0	0	0	0	0	0.4	0
3898_OG5_150608_7 - FUNGI_YHR036W	YHR036W	"BRL1 - Essential nuclear envelope integral membrane protein identified as a suppressor of a conditional mutation in the major karyopherin, CRM1; homologous to and interacts with Brr6p, a nuclear envelope protein involved in nuclear export"	1	0	0	0	0	0	0.4	0.0625
3899_OG5_150683_7 - FUNGI_YCR095C	YCR095C	"OCA4 - Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts"	1	0	0	0	0	0	0.4	0.0625
3900_OG5_150691_7 - FUNGI_YMR115W	YMR115W	"MGR3 - Subunit of the mitochondrial (mt) i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr1p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA"	1	0	0	0	0	0	0.4	0
3901_OG5_150707_7 - FUNGI_YDR349C	YDR349C	"YPS7 - Putative GPI-anchored aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; located in the cytoplasm and endoplasmic reticulum"	1	0	0	0	0	0	0.4	0
3902_OG5_152078_7 - FUNGI_YCR071C	YCR071C	IMG2 - Mitochondrial ribosomal protein of the large subunit	1	0	0	0	0	0	0.4	0
3903_OG5_152101_7 - FUNGI_YMR060C	YMR060C	"SAM37 - Component of the Sorting and Assembly Machinery (SAM or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; contributes to SAM complex stability"	1	0	0	0	0	0	0.4	0
3904_OG5_152110_7 - FUNGI_YDL092W	YDL092W	"SRP14 - Signal recognition particle (SRP) subunit, interacts with the RNA component of SRP to form the Alu domain, which is the region of SRP responsible for arrest of nascent chain elongation during membrane targeting; homolog of mammalian SRP14"	1	0	0	0	0	0	0.4	0
3905_OG5_152245_7 - FUNGI_YER139C	YER139C	RTR1 - CTD phosphatase; dephosphorylates S5-P in the C-terminal domain of Rpo21p; has a cysteine-rich motif required for function and conserved in eukaryotes; shuttles between the nucleus and cytoplasm	1	0	0	0	0	0	0.4	0
3906_OG5_152256_7 - FUNGI_YPR171W	YPR171W	BSP1 - Adapter that links synaptojanins Inp52p and Inp53p to the cortical actin cytoskeleton	1	0	0	0	0	0	0.4	0
3907_OG5_152305_7 - FUNGI_YML114C	YML114C	"TAF8 - TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation"	1	0	0	0	0	0	0.4	0
3908_OG5_152410_7 - FUNGI_YER040W	YER040W	"GLN3 - Transcriptional activator of genes regulated by nitrogen catabolite repression (NCR), localization and activity regulated by quality of nitrogen source"	1	0	0	0	0	0	0.4	0
3909_OG5_152553_7 - FUNGI_YMR031C	YMR031C	"EIS1 - Component of the eisosome that is required for proper eisosome assembly; similarity to Ykl050cp and Uso1p; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies"	1	0	0	0	0	0	0.4	0
3910_OG5_152648_7 - FUNGI_YLR363W-A	YLR363W-A	YLR363W-A - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus	1	0	0	0	0	0	0.4	0
3911_OG5_152657_7 - FUNGI_YMR059W	YMR059W	"SEN15 - Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p"	1	0	0	0	0	0	0.4	0
3912_OG5_152666_7 - FUNGI_YBR095C	YBR095C	RXT2 - Subunit of the histone deacetylase Rpd3L complex; possibly involved in cell fusion and invasive growth	1	0	0	0	0	0	0.4	0
3913_OG5_152668_7 - FUNGI_YDL189W	YDL189W	"RBS1 - Protein of unknown function, identified as a high copy suppressor of psk1 psk2 mutations that confer temperature-sensitivity for galactose utilization; proposed to bind single-stranded nucleic acids via its R3H domain"	1	0	0	0	0	0	0.4	0
3914_OG5_152690_7 - FUNGI_YDR421W	YDR421W	ARO80 - Zinc finger transcriptional activator of the Zn2Cys6 family; activates transcription of aromatic amino acid catabolic genes in the presence of aromatic amino acids	1	0	0	0	0	0	0.4	0
3915_OG5_152693_7 - FUNGI_YPL206C	YPL206C	PGC1 - Phosphatidyl Glycerol phospholipase C; regulates the phosphatidylglycerol (PG) content via a phospholipase C-type degradation mechanism; contains glycerophosphodiester phosphodiesterase motifs	1	0	0	0	0	0	0.4	0
3916_OG5_152694_7 - FUNGI_YKL055C	YKL055C	"OAR1 - Mitochondrial 3-oxoacyl-[acyl-carrier-protein] reductase, may comprise a type II mitochondrial fatty acid synthase along with Mct1p"	1	0	0	0	0	0	0.4	0
3917_OG5_152697_7 - FUNGI_YNL177C	YNL177C	MRPL22 - Mitochondrial ribosomal protein of the large subunit	1	0	0	0	0	0	0.4	0
3918_OG5_152698_7 - FUNGI_YJL148W	YJL148W	RPA34 - RNA polymerase I subunit A34.5	1	0	0	0	0	0	0.4	0
3919_OG5_152720_7 - FUNGI_YBL090W	YBL090W	MRP21 - Mitochondrial ribosomal protein of the small subunit; MRP21 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences	1	0	0	0	0	0	0.4	0
3920_OG5_152724_7 - FUNGI_YLR407W	YLR407W	YLR407W - Putative protein of unknown function; null mutant displays elongated buds and a large fraction of budded cells have only one nucleus	1	0	0	0	0	0	0.4	0
3921_OG5_152727_7 - FUNGI_YOR305W	YOR305W	RRG7 - Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); YOR305W is not an essential gene	1	0	0	0	0	0	0.4	0
3922_OG5_152735_7 - FUNGI_YAL001C	YAL001C	TFC3 - Largest of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauB domain of TFIIIC that binds DNA at the BoxB promoter sites of tRNA and similar genes; cooperates with Tfc6p in DNA binding	1	0	0	0	0	0	0.4	0
3923_OG5_152739_7 - FUNGI_YLL063C	YLL063C	"AYT1 - Acetyltransferase; catalyzes trichothecene 3-O-acetylation, suggesting a possible role in trichothecene biosynthesis"	1	0	0	0	0	0	0.4	0
3924_OG5_152757_7 - FUNGI_YOR266W	YOR266W	"PNT1 - Mitochondrial integral inner membrane protein involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p; deletion mutant sensitive to the anti-Pneumocystis carinii drug pentamidine"	1	0	0	0	0	0	0.4	0
3925_OG5_152764_7 - FUNGI_YOL019W	YOL019W	YOL019W - Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole	1	0	0	0	0	0	0.4	0
3926_OG5_152774_7 - FUNGI_YOR059C	YOR059C	YOR059C - Lipid particle protein of unknown function; contains a putative lipase serine active site; induced by transcription factor RPN4	1	0	0	0	0	0	0.4	0
3927_OG5_152775_7 - FUNGI_YNL042W	YNL042W	"BOP3 - Protein of unknown function, potential Cdc28p substrate; overproduction confers resistance to methylmercury"	1	0	0	0	0	0	0.4	0
3928_OG5_152777_7 - FUNGI_YIL084C	YIL084C	"SDS3 - Component of the Rpd3p/Sin3p deacetylase complex required for its structural integrity and catalytic activity, involved in transcriptional silencing and required for sporulation; cells defective in SDS3 display pleiotropic phenotypes"	1	0	0	0	0	0	0.4	0
3929_OG5_152783_7 - FUNGI_YNL012W	YNL012W	SPO1 - Meiosis-specific prospore protein; required for meiotic spindle pole body duplication and separation; required to produce bending force necessary for proper prospore membrane assembly during sporulation; has similarity to phospholipase B	1	0	0	0	0	0	0.4	0
3930_OG5_152799_7 - FUNGI_YOR158W	YOR158W	"PET123 - Mitochondrial ribosomal protein of the small subunit; PET123 exhibits genetic interactions with PET122, which encodes a COX3 mRNA-specific translational activator"	1	0	0	0	0	0	0.4	0
3931_OG5_152828_7 - FUNGI_YPR179C	YPR179C	HDA3 - Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex that contains an Hda1p homodimer and an Hda2p-Hda3p heterodimer; required for the activity of the complex; has similarity to Hda2p	1	0	0	0	0	0	0.4	0
3932_OG5_152838_7 - FUNGI_YOL149W	YOL149W	"DCP1 - Subunit of the Dcp1p-Dcp2p decapping enzyme complex, which removes the 5' cap structure from mRNAs prior to their degradation; enhances the activity of catalytic subunit Dcp2p; regulated by DEAD box protein Dhh1p"	1	0	0	0	0	0	0.4	0
3933_OG5_152840_7 - FUNGI_YDR459C	YDR459C	PFA5 - Palmitoyltransferase with autoacylation activity; likely functions in pathway(s) outside Ras; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain	1	0	0	0	0	0	0.4	0
3934_OG5_152880_7 - FUNGI_YMR287C	YMR287C	"DSS1 - 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs"	1	0	0	0	0	0	0.4	0
3935_OG5_152888_7 - FUNGI_YKR060W	YKR060W	UTP30 - Subunit of U3-containing 90S preribosome complex involved in production of 18S rRNA and assembly of small ribosomal subunit	1	0	0	0	0	0	0.4	0
3936_OG5_152907_7 - FUNGI_YDR262W	YDR262W	YDR262W - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole and is induced in response to the DNA-damaging agent MMS; gene expression increases in response to Zymoliase treatment	1	0	0	0	0	0	0.4	0
3937_OG5_152908_7 - FUNGI_YBR130C	YBR130C	SHE3 - Protein that acts as an adaptor between Myo4p and the She2p-mRNA complex; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud; also required for cortical ER inheritance	1	0	0	0	0	0	0.4	0
3938_OG5_152999_7 - FUNGI_YPL047W	YPL047W	"SGF11 - Integral subunit of SAGA histone acetyltransferase complex, regulates transcription of a subset of SAGA-regulated genes, required for the Ubp8p association with SAGA and for H2B deubiquitylation"	1	0	0	0	0	0	0.4	0
3939_OG5_153028_7 - FUNGI_YMR021C	YMR021C	MAC1 - Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport	1	0	0	0	0	0	0.4	0
3940_OG5_153032_7 - FUNGI_YBL093C	YBL093C	ROX3 - Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme	1	0	0	0	0	0	0.4	0
3941_OG5_153033_7 - FUNGI_YOR205C	YOR205C	"GEP3 - Protein of unknown function; null mutant is defective in respiration and interacts synthetically with prohibitin (phb1); the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies"	1	0	0	0	0	0	0.4	0
3942_OG5_153041_7 - FUNGI_YBL014C	YBL014C	"RRN6 - Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p"	1	0	0	0	0	0	0.4	0
3943_OG5_153042_7 - FUNGI_YOR073W	YOR073W	"SGO1 - Component of the spindle checkpoint, involved in sensing lack of tension on mitotic chromosomes; protects centromeric Rec8p at meiosis I; required for accurate chromosomal segregation at meiosis II and for mitotic chromosome stability"	1	0	0	0	0	0	0.4	0
3944_OG5_153073_7 - FUNGI_YAL008W	YAL008W	FUN14 - Mitochondrial protein of unknown function	1	0	0	0	0	0	0.4	0
3945_OG5_153074_7 - FUNGI_YNL193W	YNL193W	YNL193W - Putative protein of unknown function; exhibits a two-hybrid interaction with Yhr151cp in a large-scale analysis	1	0	0	0	0	0	0.4	0
3946_OG5_153076_7 - FUNGI_YCR035C	YCR035C	"RRP43 - Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp43p (OIP2, EXOSC8)"	1	0	0	0	0	0	0.4	0
3947_OG5_153084_7 - FUNGI_YIL098C	YIL098C	"FMC1 - Mitochondrial matrix protein, required for assembly or stability at high temperature of the F1 sector of mitochondrial F1F0 ATP synthase; null mutant temperature sensitive growth on glycerol is suppressed by multicopy expression of Odc1p"	1	0	0	0	0	0	0.4	0
3948_OG5_153087_7 - FUNGI_YHR101C	YHR101C	"BIG1 - Integral membrane protein of the endoplasmic reticulum, required for normal content of cell wall beta-1,6-glucan"	1	0	0	0	0	0	0.4	0
3949_OG5_153095_7 - FUNGI_YLL005C	YLL005C	"SPO75 - Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis"	1	0	0	0	0	0	0.4	0
3950_OG5_153096_7 - FUNGI_YJR041C	YJR041C	"URB2 - Nucleolar protein required for normal metabolism of the rRNA primary transcript, proposed to be involved in ribosome biogenesis"	1	0	0	0	0	0	0.4	0
3951_OG5_153097_7 - FUNGI_YGL005C	YGL005C	"COG7 - Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments"	1	0	0	0	0	0	0.4	0
3952_OG5_153123_7 - FUNGI_YDR143C	YDR143C	SAN1 - Ubiquitin-protein ligase; involved in the proteasome-dependent degradation of aberrant nuclear proteins; targets substrates with regions of exposed hydrophobicity containing 5 or more contiguous hydrophobic residues; contains intrinsically disordered regions that contribute to substrate recognition	1	0	0	0	0	0	0.4	0
3953_OG5_153233_7 - FUNGI_YGL160W	YGL160W	"AIM14 - Protein with similarity to iron/copper reductases (FRE1-8), possibly involved in iron homeostasis; may interact with ribosomes; null mutant displays elevated frequency of mitochondrial genome loss"	1	0	0	0	0	0	0.4	0
3954_OG5_153329_7 - FUNGI_YKL185W	YKL185W	"ASH1 - Zinc-finger inhibitor of HO transcription; mRNA is localized and translated in the distal tip of anaphase cells, resulting in accumulation of Ash1p in daughter cell nuclei and inhibition of HO expression; potential Cdc28p substrate"	1	0	0	0	0	0	0.4	0
3955_OG5_153658_7 - FUNGI_YPL165C	YPL165C	"SET6 - SET domain protein of unknown function; deletion heterozygote is sensitive to compounds that target ergosterol biosynthesis, may be involved in compound availability"	1	0	0	0	0	0	0.4	0
3956_OG5_153683_7 - FUNGI_YBR207W	YBR207W	FTH1 - Putative high affinity iron transporter involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis	1	0	0	0	0	0	0.4	0
3957_OG5_153712_7 - FUNGI_YHR083W	YHR083W	"SAM35 - Essential component of the sorting and assembly machinery (SAM complex or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their insertion into the outer membrane"	1	0	0	0	0	0	0.4	0
3958_OG5_153719_7 - FUNGI_YFR045W	YFR045W	"YFR045W - Putative mitochondrial transport protein; null mutant is viable, exhibits decreased levels of chitin and normal resistance to calcofluor white"	1	0	0	0	0	0	0.4	0
3959_OG5_153721_7 - FUNGI_YDR020C	YDR020C	DAS2 - Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; weak similarity with uridine kinases and with phosphoribokinases	1	0	0	0	0	0	0.4	0
3960_OG5_153722_7 - FUNGI_YDR296W	YDR296W	MHR1 - Protein involved in homologous recombination in mitochondria; required for recombination-dependent mtDNA partitioning; involved in stimulation of mitochondrial DNA replication in response to oxidative stress	1	0	0	0	0	0	0.4	0
3961_OG5_153723_7 - FUNGI_YNR040W	YNR040W	"YNR040W - Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"	1	0	0	0	0	0	0.4	0
3962_OG5_153725_7 - FUNGI_YPL180W	YPL180W	"TCO89 - Subunit of TORC1 (Tor1p or Tor2p-Kog1p-Lst8p-Tco89p), a complex that regulates growth in response to nutrient availability; cooperates with Ssd1p in the maintenance of cellular integrity; deletion strains are hypersensitive to rapamycin"	1	0	0	0	0	0	0.4	0
3963_OG5_153727_7 - FUNGI_YFR029W	YFR029W	"PTR3 - Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes"	1	0	0	0	0	0	0.4	0
3964_OG5_153730_7 - FUNGI_YBL066C	YBL066C	"SEF1 - Putative transcription factor, has homolog in Kluyveromyces lactis"	1	0	0	0	0	0	0.4	0
3965_OG5_153731_7 - FUNGI_YJL066C	YJL066C	"MPM1 - Mitochondrial membrane protein of unknown function, contains no hydrophobic stretches"	1	0	0	0	0	0	0.4	0
3966_OG5_153732_7 - FUNGI_YDL157C	YDL157C	"YDL157C - Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"	1	0	0	0	0	0	0.4	0
3967_OG5_153733_7 - FUNGI_YPR083W	YPR083W	MDM36 - Mitochondrial protein required for normal mitochondrial morphology and inheritance; proposed involvement in the formation of Dnm1p and Num1p-containing cortical anchor complexes that promote mitochondrial fission	1	0	0	0	0	0	0.4	0
3968_OG5_153735_7 - FUNGI_YGR026W	YGR026W	YGR026W - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery	1	0	0	0	0	0	0.4	0
3969_OG5_153736_7 - FUNGI_YGR247W	YGR247W	"CPD1 - Cyclic nucleotide phosphodiesterase, hydrolyzes ADP-ribose 1'', 2''-cyclic phosphate to ADP-ribose 1''-phosphate; may have a role in tRNA splicing; no detectable phenotype is conferred by null mutation or by overexpression"	1	0	0	0	0	0	0.4	0
3970_OG5_153737_7 - FUNGI_YOR329C	YOR329C	SCD5 - Protein required for normal actin organization and endocytosis; targeting subunit for protein phosphatase type 1; undergoes Crm1p-dependent nuclear-cytoplasmic shuttling; multicopy suppressor of clathrin deficiency	1	0	0	0	0	0	0.4	0
3971_OG5_153738_7 - FUNGI_YGR128C	YGR128C	UTP8 - Nucleolar protein required for export of tRNAs from the nucleus; also copurifies with the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA	1	0	0	0	0	0	0.4	0
3972_OG5_153739_7 - FUNGI_YER093C-A	YER093C-A	AIM11 - Protein of unknown function; null mutant is viable but shows increased loss of mitochondrial genome and synthetic interaction with prohibitin (phb1); contains an intron	1	0	0	0	0	0	0.4	0
3973_OG5_153740_7 - FUNGI_YGL138C	YGL138C	YGL138C - Putative protein of unknown function; has no significant sequence similarity to any known protein	1	0	0	0	0	0	0.4	0
3974_OG5_153742_7 - FUNGI_YIL127C	YIL127C	RRT14 - Putative protein of unknown function; identified in a screen for mutants with decreased levels of rDNA transcription; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis	1	0	0	0	0	0	0.4	0
3975_OG5_153743_7 - FUNGI_YDR347W	YDR347W	"MRP1 - Mitochondrial ribosomal protein of the small subunit; MRP1 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator, and with PET123, encoding a small subunit mitochondrial ribosomal protein"	1	0	0	0	0	0	0.4	0
3976_OG5_153745_7 - FUNGI_YBR185C	YBR185C	MBA1 - Membrane-associated mitochondrial ribosome receptor; forms a complex with Mdm38p that may facilitate recruitment of mRNA-specific translational activators to ribosomes; possible role in protein export from the matrix to inner membrane	1	0	0	0	0	0	0.4	0
3977_OG5_153747_7 - FUNGI_YHL029C	YHL029C	"OCA5 - Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts"	1	0	0	0	0	0	0.4	0
3978_OG5_153748_7 - FUNGI_YPR068C	YPR068C	"HOS1 - Class I histone deacetylase (HDAC) family member that deacetylates Smc3p on lysine residues at anaphase onset; has sequence similarity to Hda1p, Rpd3p, Hos2p, and Hos3p; interacts with the Tup1p-Ssn6p corepressor complex"	1	0	0	0	0	0	0.4	0
3979_OG5_153749_7 - FUNGI_YPL113C	YPL113C	YPL113C - Glyoxylate reductase; acts on glyoxylate and hydroxypyruvate substrates; YPL113C is not an essential gene	1	0	0	0	0	0	0.4	0
3980_OG5_153752_7 - FUNGI_YDL088C	YDL088C	"ASM4 - Nuclear pore complex subunit, part of a subcomplex also containing Nup53p, Nup170p, and Pse1p"	1	0	0	0	0	0	0.4	0
3981_OG5_153754_7 - FUNGI_YHR041C	YHR041C	SRB2 - Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; general transcription factor involved in telomere maintenance	1	0	0	0	0	0	0.4	0
3982_OG5_153758_7 - FUNGI_YPL034W	YPL034W	YPL034W - Putative protein of unknown function; YPL034W is not essential gene	1	0	0	0	0	0	0.4	0
3983_OG5_153759_7 - FUNGI_YLR033W	YLR033W	"RSC58 - Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance"	1	0	0	0	0	0	0.4	0
3984_OG5_153760_7 - FUNGI_YBR158W	YBR158W	"AMN1 - Protein required for daughter cell separation, multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucine-rich repeat motifs; expression is induced by the Mitotic Exit Network (MEN)"	1	0	0	0	0	0	0.4	0
3985_OG5_153761_7 - FUNGI_YKL077W	YKL077W	YKL077W - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole	1	0	0	0	0	0	0.4	0
3986_OG5_153762_7 - FUNGI_YPL118W	YPL118W	MRP51 - Mitochondrial ribosomal protein of the small subunit; MRP51 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences	1	0	0	0	0	0	0.4	0
3987_OG5_153763_7 - FUNGI_YOR355W	YOR355W	"GDS1 - Protein of unknown function, required for growth on glycerol as a carbon source; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"	1	0	0	0	0	0	0.4	0
3988_OG5_153765_7 - FUNGI_YOL111C	YOL111C	MDY2 - Protein with a role in insertion of tail-anchored proteins into the ER membrane; forms a complex with Get4p; required for efficient mating; involved in shmoo formation and nuclear migration in the pre-zygote; associates with ribosomes	1	0	0	0	0	0	0.4	0
3989_OG5_153766_7 - FUNGI_YOR038C	YOR038C	"HIR2 - Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; recruits Swi-Snf complexes to histone gene promoters; promotes heterochromatic gene silencing with Asf1p"	1	0	0	0	0	0	0.4	0
3990_OG5_153768_7 - FUNGI_YMR263W	YMR263W	"SAP30 - Subunit of a histone deacetylase complex, along with Rpd3p and Sin3p, that is involved in silencing at telomeres, rDNA, and silent mating-type loci; involved in telomere maintenance"	1	0	0	0	0	0	0.4	0
3991_OG5_153770_7 - FUNGI_YDL107W	YDL107W	"MSS2 - Peripherally bound inner membrane protein of the mitochondrial matrix involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p"	1	0	0	0	0	0	0.4	0
3992_OG5_153771_7 - FUNGI_YOL144W	YOL144W	NOP8 - Nucleolar protein required for 60S ribosomal subunit biogenesis	1	0	0	0	0	0	0.4	0
3993_OG5_153773_7 - FUNGI_YNL211C	YNL211C	YNL211C - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL211C is not an essential gene	1	0	0	0	0	0	0.4	0
3994_OG5_153775_7 - FUNGI_YJL157C	YJL157C	"FAR1 - Cyclin-dependent kinase inhibitor that mediates cell cycle arrest in response to pheromone; also forms a complex with Cdc24p, Ste4p, and Ste18p that may specify the direction of polarized growth during mating; potential Cdc28p substrate"	1	0	0	0	0	0	0.4	0
3995_OG5_153776_7 - FUNGI_YCL014W	YCL014W	BUD3 - Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding	1	0	0	0	0	0	0.4	0
3996_OG5_153777_7 - FUNGI_YMR112C	YMR112C	MED11 - Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential protein	1	0	0	0	0	0	0.4	0
3997_OG5_153780_7 - FUNGI_YBR272C	YBR272C	HSM3 - Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); involved in DNA mismatch repair during slow growth; weak similarity to Msh1p; related to human 19S subunit S5b	1	0	0	0	0	0	0.4	0
3998_OG5_153781_7 - FUNGI_YLR356W	YLR356W	"ATG33 - Mitochondrial mitophagy-specific protein; required primarily for mitophagy induced at the post-log phase; not required for other types of selective autophagy or macroautophagy; conserved within fungi, but not in higher eukaryotes"	1	0	0	0	0	0	0.4	0
3999_OG5_153782_7 - FUNGI_YOR242C	YOR242C	SSP2 - Sporulation specific protein that localizes to the spore wall; required for sporulation at a point after meiosis II and during spore wall formation; SSP2 expression is induced midway in meiosis	1	0	0	0	0	0	0.4	0
4000_OG5_155503_7 - FUNGI_YBR293W	YBR293W	VBA2 - Permease of basic amino acids in the vacuolar membrane	1	0	0	0	0	0	0.4	0
4001_OG5_155772_7 - FUNGI_YPR106W	YPR106W	"ISR1 - Predicted protein kinase, overexpression causes sensitivity to staurosporine, which is a potent inhibitor of protein kinase C"	1	0	0	0	0	0	0.4	0
4002_OG5_156176_7 - FUNGI_YLR443W	YLR443W	ECM7 - Non-essential putative integral membrane protein with a role in calcium uptake; mutant has cell wall defects and Ca+ uptake deficiencies; transcription is induced under conditions of zinc deficiency	1	0	0	0	0	0	0.4	0
4003_OG5_156214_7 - FUNGI_YHR118C	YHR118C	"ORC6 - Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; phosphorylated by Cdc28p"	1	0	0	0	0	0	0.4	0
4004_OG5_157063_7 - FUNGI_YER124C	YER124C	"DSE1 - Daughter cell-specific protein, may regulate cross-talk between the mating and filamentation pathways; deletion affects cell separation after division and sensitivity to alpha-factor and drugs affecting the cell wall"	1	0	0	0	0	0	0.4	0
4005_OG5_157064_7 - FUNGI_YML048W	YML048W	"GSF2 - ER localized integral membrane protein that may promote secretion of certain hexose transporters, including Gal2p; involved in glucose-dependent repression"	1	0	0	0	0	0	0.4	0
4006_OG5_157065_7 - FUNGI_YML115C	YML115C	"VAN1 - Component of the mannan polymerase I, which contains Van1p and Mnn9p and is involved in the first steps of mannan synthesis; mutants are vanadate-resistant"	1	0	0	0	0	0	0.4	0
4007_OG5_157066_7 - FUNGI_YGL113W	YGL113W	"SLD3 - Protein involved in the initiation of DNA replication, required for proper assembly of replication proteins at the origins of replication; interacts with Cdc45p"	1	0	0	0	0	0	0.4	0
4008_OG5_134499_7 - FUNGI_YGR169C	YGR169C	"PUS6 - tRNA:pseudouridine synthase, catalyzes the conversion of uridine to pseudouridine at position 31 in cytoplasmic and mitochondrial tRNAs; mutation of Asp168 to Ala abolishes enzyme activity; not essential for viability"	1	0	0	0.125	0.095238095	0	0.4	0.25
4009_OG5_135192_7 - FUNGI_YDR067C	YDR067C	"OCA6 - Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying positive-strand RNA virus replication; null mutation confers sensitivity to tunicamycin and DTT"	1	0	0	0.125	0.095238095	0	0.4	0.3125
4010_OG5_140592_7 - FUNGI_YKL164C	YKL164C	"PIR1 - O-glycosylated protein required for cell wall stability; attached to the cell wall via beta-1,3-glucan; mediates mitochondrial translocation of Apn1p; expression regulated by the cell integrity pathway and by Swi5p during the cell cycle"	1	0	0	0.125	0.047619048	0	0.4	0
4011_OG5_140592_7 - FUNGI_YJL159W	YJL159W	"HSP150 - O-mannosylated heat shock protein that is secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation"	1	0	0	0.125	0.047619048	0	0.4	0
4012_OG5_143026_7 - FUNGI_YAL011W	YAL011W	"SWC3 - Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for formation of nuclear-associated array of smooth endoplasmic reticulum known as karmellae"	1	0	0.027777778	0	0.047619048	0	0.4	0
4013_OG5_141405_7 - FUNGI_YJR154W	YJR154W	YJR154W - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	1	0	0.027777778	0.125	0	0	0.4	0
4014_OG5_147027_7 - FUNGI_YNL166C	YNL166C	"BNI5 - Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner"	1	0	0	0.125	0	0	0.4	0
4015_OG5_134369_7 - FUNGI_YKR063C	YKR063C	LAS1 - Essential nuclear protein possibly involved in bud formation and morphogenesis; mutants require the SSD1-v allele for viability	1	0	0	0.125	0.095238095	0.142857143	0.35	0.25
4016_OG5_140177_7 - FUNGI_YLR426W	YLR426W	TDA5 - Putative protein of unknown function; detected in highly purified mitochondria in high-throughput studies; proposed to be involved in resistance to mechlorethamine and streptozotocin; null mutant sensitive to expression of top1-T722A allele	1	0	0	0.125	0.095238095	0.071428571	0.35	0.125
4017_OG5_142882_7 - FUNGI_YBR125C	YBR125C	PTC4 - Cytoplasmic type 2C protein phosphatase (PP2C); identified as a high-copy number suppressor of cnb1 mpk1 synthetic lethality; overexpression decreases high-osmolarity induced Hog1p phosphorylation and kinase activity	1	0	0	0	0.095238095	0	0.35	0.0625
4018_OG5_146786_7 - FUNGI_YNL234W	YNL234W	YNL234W - Protein of unknown function with similarity to globins; has a functional heme-binding domain; mutant has aneuploidy tolerance; transcription induced by stress conditions; may be involved in glucose signaling or metabolism; regulated by Rgt1	1	0	0	0	0.095238095	0	0.35	0
4019_OG5_149863_7 - FUNGI_YOR064C	YOR064C	"YNG1 - Subunit of the NuA3 histone acetyltransferase complex that acetylates histone H3; contains PHD finger domain that interacts with methylated histone H3, has similarity to the human tumor suppressor ING1"	1	0	0	0	0.095238095	0	0.35	0
4020_OG5_150013_7 - FUNGI_YPL055C	YPL055C	"LGE1 - Protein of unknown function; null mutant forms abnormally large cells, and homozygous diploid null mutant displays delayed premeiotic DNA synthesis and reduced efficiency of meiotic nuclear division"	1	0	0	0	0.095238095	0	0.35	0
4021_OG5_153371_7 - FUNGI_YOR219C	YOR219C	"STE13 - Dipeptidyl aminopeptidase, Golgi integral membrane protein that cleaves on the carboxyl side of repeating -X-Ala- sequences, required for maturation of alpha factor, transcription is induced by a-factor"	1	0.0625	0	0	0	0	0.35	0
4022_OG5_153728_7 - FUNGI_YBR230C	YBR230C	OM14 - Integral mitochondrial outer membrane protein; abundance is decreased in cells grown in glucose relative to other carbon sources; appears to contain 3 alpha-helical transmembrane segments; ORF encodes a 97-basepair intron	1	0.0625	0	0	0	0	0.35	0
4023_OG5_138404_7 - FUNGI_YPL174C	YPL174C	"NIP100 - Large subunit of the dynactin complex, which is involved in partitioning the mitotic spindle between mother and daughter cells; putative ortholog of mammalian p150(glued)"	1	0	0	0	0.047619048	0	0.35	0.25
4024_OG5_144547_7 - FUNGI_YIL005W	YIL005W	"EPS1 - ER protein with chaperone and co-chaperone activity, involved in retention of resident ER proteins; has a role in recognizing proteins targeted for ER-associated degradation (ERAD), member of the protein disulfide isomerase family"	1	0	0	0	0.047619048	0	0.35	0.0625
4025_OG5_146521_7 - FUNGI_YMR273C	YMR273C	ZDS1 - Protein with a role in regulating Swe1p-dependent polarized growth; interacts with silencing proteins at the telomere; has a role in Bcy1p localization; implicated in mRNA nuclear export; involved in mitotic exit through Cdc14p regulation	1	0	0	0	0.047619048	0	0.35	0
4026_OG5_146521_7 - FUNGI_YML109W	YML109W	ZDS2 - Protein with a role in regulating Swe1p-dependent polarized growth; interacts with Cdc55p; interacts with silencing proteins at the telomere; implicated in the mitotic exit network through regulation of Cdc14p localization; paralog of Zds1p	1	0	0	0	0.047619048	0	0.35	0
4027_OG5_146756_7 - FUNGI_YOR178C	YOR178C	"GAC1 - Regulatory subunit for Glc7p type-1 protein phosphatase (PP1), tethers Glc7p to Gsy2p glycogen synthase, binds Hsf1p heat shock transcription factor, required for induction of some HSF-regulated genes under heat shock"	1	0	0	0	0.047619048	0	0.35	0
4028_OG5_147579_7 - FUNGI_YIL156W	YIL156W	UBP7 - Ubiquitin-specific protease that cleaves ubiquitin-protein fusions	1	0	0	0	0.047619048	0	0.35	0
4029_OG5_149567_7 - FUNGI_YDR160W	YDR160W	"SSY1 - Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes"	1	0	0	0	0.047619048	0	0.35	0
4030_OG5_149588_7 - FUNGI_YBR057C	YBR057C	"MUM2 - Cytoplasmic protein essential for meiotic DNA replication and sporulation; interacts with Orc2p, which is a component of the origin recognition complex"	1	0	0	0	0.047619048	0	0.35	0
4031_OG5_149810_7 - FUNGI_YJR127C	YJR127C	"RSF2 - Zinc-finger protein involved in transcriptional control of both nuclear and mitochondrial genes, many of which specify products required for glycerol-based growth, respiration, and other functions"	1	0	0	0	0.047619048	0	0.35	0
4032_OG5_149810_7 - FUNGI_YML081W	YML081W	"TDA9 - DNA-binding protein, putative transcription factor; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene"	1	0	0	0	0.047619048	0	0.35	0
4033_OG5_149862_7 - FUNGI_YML046W	YML046W	"PRP39 - U1 snRNP protein involved in splicing, contains multiple tetriatricopeptide repeats"	1	0	0	0	0.047619048	0	0.35	0.0625
4034_OG5_150439_7 - FUNGI_YML125C	YML125C	"PGA3 - Putative cytochrome b5 reductase, localized to the plasma membrane; may be involved in regulation of lifespan; required for maturation of Gas1p and Pho8p, proposed to be involved in protein trafficking"	1	0	0	0	0.047619048	0	0.35	0
4035_OG5_152885_7 - FUNGI_YHR059W	YHR059W	"FYV4 - Protein of unknown function, required for survival upon exposure to K1 killer toxin"	1	0	0	0	0.047619048	0	0.35	0
4036_OG5_152889_7 - FUNGI_YER111C	YER111C	"SWI4 - DNA binding component of the SBF complex (Swi4p-Swi6p), a transcriptional activator that in concert with MBF (Mbp1-Swi6p) regulates late G1-specific transcription of targets including cyclins and genes required for DNA synthesis and repair"	1	0	0	0	0.047619048	0	0.35	0
4037_OG5_153603_7 - FUNGI_YNL307C	YNL307C	MCK1 - Protein serine/threonine/tyrosine (dual-specificity) kinase involved in control of chromosome segregation and in regulating entry into meiosis; related to mammalian glycogen synthase kinases of the GSK-3 family	1	0	0	0	0.047619048	0	0.35	0
4038_OG5_153769_7 - FUNGI_YGR251W	YGR251W	YGR251W - Essential protein required for maturation of 18S rRNA; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the nucleolus	1	0	0	0	0.047619048	0	0.35	0
4039_OG5_153460_7 - FUNGI_YJR032W	YJR032W	"CPR7 - Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity"	1	0	0.027777778	0	0	0	0.35	0
4040_OG5_153492_7 - FUNGI_YOL095C	YOL095C	"HMI1 - Mitochondrial inner membrane localized ATP-dependent DNA helicase, required for the maintenance of the mitochondrial genome; not required for mitochondrial transcription; has homology to E. coli helicase uvrD"	1	0	0.027777778	0	0	0	0.35	0
4041_OG5_135050_7 - FUNGI_YBR068C	YBR068C	"BAP2 - High-affinity leucine permease, functions as a branched-chain amino acid permease involved in the uptake of leucine, isoleucine and valine; contains 12 predicted transmembrane domains"	1	0	0	0	0	0	0.35	0
4042_OG5_135050_7 - FUNGI_YBR069C	YBR069C	"TAT1 - Amino acid transport protein for valine, leucine, isoleucine, and tyrosine, low-affinity tryptophan and histidine transporter; overexpression confers FK506 and FTY720 resistance"	1	0	0	0	0	0	0.35	0
4043_OG5_135050_7 - FUNGI_YCL025C	YCL025C	"AGP1 - Low-affinity amino acid permease with broad substrate range, involved in uptake of asparagine, glutamine, and other amino acids; expression is regulated by the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p)"	1	0	0	0	0	0	0.35	0
4044_OG5_135050_7 - FUNGI_YDR508C	YDR508C	"GNP1 - High-affinity glutamine permease, also transports Leu, Ser, Thr, Cys, Met and Asn; expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids"	1	0	0	0	0	0	0.35	0
4045_OG5_135050_7 - FUNGI_YDR046C	YDR046C	"BAP3 - Amino acid permease involved in the uptake of cysteine, leucine, isoleucine and valine"	1	0	0	0	0	0	0.35	0
4046_OG5_137586_7 - FUNGI_YGL178W	YGL178W	"MPT5 - Member of the Puf family of RNA-binding proteins; binds to mRNAs encoding chromatin modifiers and spindle pole body components; involved in longevity, maintenance of cell wall integrity, and sensitivity to and recovery from pheromone arrest"	1	0	0	0	0	0	0.35	0.1875
4047_OG5_149836_7 - FUNGI_YHR146W	YHR146W	CRP1 - Protein that binds to cruciform DNA structures	1	0	0	0	0	0	0.35	0
4048_OG5_149836_7 - FUNGI_YNL173C	YNL173C	MDG1 - Plasma membrane protein involved in G-protein mediated pheromone signaling pathway; overproduction suppresses bem1 mutations	1	0	0	0	0	0	0.35	0
4049_OG5_149858_7 - FUNGI_YER132C	YER132C	"PMD1 - Protein with an N-terminal kelch-like domain, putative negative regulator of early meiotic gene expression; required, with Mds3p, for growth under alkaline conditions"	1	0	0	0	0	0	0.35	0
4050_OG5_149858_7 - FUNGI_YGL197W	YGL197W	"MDS3 - Putative component of the TOR regulatory pathway; negative regulator of early meiotic gene expression; required, with Pmd1p, for growth under alkaline conditions; has an N-terminal kelch-like domain"	1	0	0	0	0	0	0.35	0
4051_OG5_149890_7 - FUNGI_YKL204W	YKL204W	"EAP1 - eIF4E-associated protein, competes with eIF4G for binding to eIF4E; inhibits cap-dependent translation; functions independently of eIF4E to maintain genetic stability; plays a role in cell growth, implicated in the TOR signaling cascade"	1	0	0	0	0	0	0.35	0
4052_OG5_150685_7 - FUNGI_YLR177W	YLR177W	YLR177W - Putative protein of unknown function; phosphorylated by Dbf2p-Mob1p in vitro; some strains contain microsatellite polymophisms at this locus; YLR177W is not an essential gene	1	0	0	0	0	0	0.35	0
4053_OG5_150685_7 - FUNGI_YDR505C	YDR505C	PSP1 - Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition	1	0	0	0	0	0	0.35	0
4054_OG5_150689_7 - FUNGI_YPL256C	YPL256C	"CLN2 - G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)"	1	0	0	0	0	0	0.35	0
4055_OG5_150689_7 - FUNGI_YMR199W	YMR199W	"CLN1 - G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)"	1	0	0	0	0	0	0.35	0
4056_OG5_150696_7 - FUNGI_YML111W	YML111W	"BUL2 - Component of the Rsp5p E3-ubiquitin ligase complex, involved in intracellular amino acid permease sorting, functions in heat shock element mediated gene expression, essential for growth in stress conditions, functional homolog of BUL1"	1	0	0	0	0	0	0.35	0
4057_OG5_150696_7 - FUNGI_YMR275C	YMR275C	"BUL1 - Ubiquitin-binding component of the Rsp5p E3-ubiquitin ligase complex, functional homolog of Bul2p, disruption causes temperature-sensitive growth, overexpression causes missorting of amino acid permeases"	1	0	0	0	0	0	0.35	0
4058_OG5_150702_7 - FUNGI_YDR475C	YDR475C	"JIP4 - Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence"	1	0	0	0	0	0	0.35	0
4059_OG5_150702_7 - FUNGI_YOR019W	YOR019W	"YOR019W - Protein of unknown function that may interact with ribosomes, based on co-purification experiments"	1	0	0	0	0	0	0.35	0
4060_OG5_150709_7 - FUNGI_YER067W	YER067W	RGI1 - Protein of unknown function involved in energy metabolism under respiratory conditions; protein abundance is increased upon intracellular iron depletion	1	0	0	0	0	0	0.35	0
4061_OG5_150709_7 - FUNGI_YIL057C	YIL057C	RGI2 - Protein of unknown function involved in energy metabolism under respiratory conditions; expression induced under carbon limitation and repressed under high glucose	1	0	0	0	0	0	0.35	0
4062_OG5_152310_7 - FUNGI_YLR119W	YLR119W	"SRN2 - Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; suppressor of rna1-1 mutation; may be involved in RNA export from nucleus"	1	0	0	0	0	0	0.35	0
4063_OG5_152667_7 - FUNGI_YDL110C	YDL110C	TMA17 - Protein of unknown function that associates with ribosomes; heterozygous deletion demonstrated increases in chromosome instability in a rad9 deletion background; protein abundance is decreased upon intracellular iron depletion	1	0	0	0	0	0	0.35	0
4064_OG5_152716_7 - FUNGI_YNL230C	YNL230C	"ELA1 - Elongin A, F-box protein that forms a heterodimer with Elc1p and is required for ubiquitin-dependent degredation of the RNA Polymerase II subunit RPO21; subunit of the Elongin-Cullin-Socs (ECS) ligase complex"	1	0	0	0	0	0	0.35	0.0625
4065_OG5_152718_7 - FUNGI_YGR156W	YGR156W	PTI1 - Essential protein that is a component of CPF (cleavage and polyadenylation factor); involved in 3' end formation of snoRNA and mRNA; interacts directly with Pta1p; has similarity to mammalian Cleavage-Stimulation Factor CstF-64	1	0	0	0	0	0	0.35	0.0625
4066_OG5_152736_7 - FUNGI_YFL048C	YFL048C	"EMP47 - Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport"	1	0	0	0	0	0	0.35	0
4067_OG5_152736_7 - FUNGI_YLR080W	YLR080W	"EMP46 - Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport"	1	0	0	0	0	0	0.35	0
4068_OG5_152800_7 - FUNGI_YMR037C	YMR037C	"MSN2 - Transcriptional activator related to Msn4p; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression"	1	0	0	0	0	0	0.35	0
4069_OG5_152800_7 - FUNGI_YKL062W	YKL062W	"MSN4 - Transcriptional activator related to Msn2p; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression"	1	0	0	0	0	0	0.35	0
4070_OG5_152837_7 - FUNGI_YDR150W	YDR150W	"NUM1 - Protein required for nuclear migration, localizes to the mother cell cortex and the bud tip; may mediate interactions of dynein and cytoplasmic microtubules with the cell cortex"	1	0	0	0	0	0	0.35	0
4071_OG5_152852_7 - FUNGI_YDR253C	YDR253C	"MET32 - Zinc-finger DNA-binding protein, involved in transcriptional regulation of the methionine biosynthetic genes, similar to Met31p"	1	0	0	0	0	0	0.35	0
4072_OG5_152852_7 - FUNGI_YPL038W	YPL038W	"MET31 - Zinc-finger DNA-binding protein, involved in transcriptional regulation of the methionine biosynthetic genes, similar to Met32p"	1	0	0	0	0	0	0.35	0
4073_OG5_152886_7 - FUNGI_YDR034C	YDR034C	LYS14 - Transcriptional activator involved in regulation of genes of the lysine biosynthesis pathway; requires 2-aminoadipate semialdehyde as co-inducer	1	0	0	0	0	0	0.35	0
4074_OG5_153029_7 - FUNGI_YNL233W	YNL233W	"BNI4 - Targeting subunit for Glc7p protein phosphatase, localized to the bud neck, required for localization of chitin synthase III to the bud neck via interaction with the chitin synthase III regulatory subunit Skt5p"	1	0	0	0	0	0	0.35	0.0625
4075_OG5_153713_7 - FUNGI_YDR463W	YDR463W	"STP1 - Transcription factor, undergoes proteolytic processing by SPS (Ssy1p-Ptr3p-Ssy5p)-sensor component Ssy5p in response to extracellular amino acids; activates transcription of amino acid permease genes and may have a role in tRNA processing"	1	0	0	0	0	0	0.35	0
4076_OG5_153713_7 - FUNGI_YHR006W	YHR006W	"STP2 - Transcription factor, activated by proteolytic processing in response to signals from the SPS sensor system for external amino acids; activates transcription of amino acid permease genes"	1	0	0	0	0	0	0.35	0
4077_OG5_153714_7 - FUNGI_YDR522C	YDR522C	"SPS2 - Protein expressed during sporulation, redundant with Sps22p for organization of the beta-glucan layer of the spore wall; S. pombe ortholog is a spore wall component"	1	0	0	0	0	0	0.35	0
4078_OG5_153714_7 - FUNGI_YCL048W	YCL048W	"SPS22 - Protein of unknown function, redundant with Sps2p for the organization of the beta-glucan layer of the spore wall"	1	0	0	0	0	0	0.35	0
4079_OG5_153715_7 - FUNGI_YNR049C	YNR049C	"MSO1 - Probable component of the secretory vesicle docking complex, acts at a late step in secretion; shows genetic and physical interactions with Sec1p; required for prospore membrane formation during sporulation"	1	0	0	0	0	0	0.35	0
4080_OG5_153726_7 - FUNGI_YLR064W	YLR064W	"PER33 - Protein that localizes to the endoplasmic reticulum with some nuclear pore complex association; deletion extends chronological lifespan; highly conserved across species, orthologous to human TMEM33 and paralogous to Pom33p"	1	0	0	0	0	0	0.35	0
4081_OG5_153729_7 - FUNGI_YER088C	YER088C	DOT6 - Protein involved in rRNA and ribosome biogenesis; binds polymerase A and C motif; subunit of the RPD3L histone deacetylase complex; similar to Tod6p; has chromatin specific SANT domain; involved in telomeric gene silencing and filamentation	1	0	0	0	0	0	0.35	0
4082_OG5_153734_7 - FUNGI_YNL002C	YNL002C	RLP7 - Nucleolar protein with similarity to large ribosomal subunit L7 proteins; constituent of 66S pre-ribosomal particles; plays an essential role in processing of precursors to the large ribosomal subunit RNAs	1	0	0	0	0	0	0.35	0.0625
4083_OG5_153746_7 - FUNGI_YBR238C	YBR238C	YBR238C - Mitochondrial membrane protein with similarity to Rmd9p; not required for respiratory growth but causes a synthetic respiratory defect in combination with rmd9 mutations; transcriptionally up-regulated by TOR; deletion increases life span	1	0	0	0	0	0	0.35	0
4084_OG5_153746_7 - FUNGI_YGL107C	YGL107C	RMD9 - Mitochondrial protein required for respiratory growth; mutant phenotype and genetic interactions suggest a role in delivering mt mRNAs to ribosomes; located on matrix face of the inner membrane and loosely associated with mitoribosomes	1	0	0	0	0	0	0.35	0
4085_OG5_153751_7 - FUNGI_YHR149C	YHR149C	SKG6 - Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p	1	0	0	0	0	0	0.35	0
4086_OG5_153755_7 - FUNGI_YBR033W	YBR033W	EDS1 - Putative zinc cluster protein; YBR033W is not an essential gene	1	0	0	0	0	0	0.35	0
4087_OG5_153755_7 - FUNGI_YKL038W	YKL038W	RGT1 - Glucose-responsive transcription factor that regulates expression of several glucose transporter (HXT) genes in response to glucose; binds to promoters and acts both as a transcriptional activator and repressor	1	0	0	0	0	0	0.35	0
4088_OG5_153767_7 - FUNGI_YGL162W	YGL162W	SUT1 - Transcription factor of the Zn[II]2Cys6 family involved in sterol uptake; involved in induction of hypoxic gene expression	1	0	0	0	0	0	0.35	0
4089_OG5_153767_7 - FUNGI_YPR009W	YPR009W	SUT2 - Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; highly similar to Sut1p	1	0	0	0	0	0	0.35	0
4090_OG5_153779_7 - FUNGI_YJL099W	YJL099W	"CHS6 - Member of the ChAPs family of proteins (Chs5p-Arf1p-binding proteins: Bch1p, Bch2p, Bud7p, Chs6p), that forms the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane"	1	0	0	0	0	0	0.35	0
4091_OG5_153779_7 - FUNGI_YKR027W	YKR027W	"BCH2 - Member of the ChAPs family of proteins (Chs5p-Arf1p-binding proteins: Bch1p, Bch2p, Bud7p, Chs6p), that forms the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane"	1	0	0	0	0	0	0.35	0
4092_OG5_155016_7 - FUNGI_YNL323W	YNL323W	"LEM3 - Membrane protein of the plasma membrane and ER, interacts specifically in vivo with the phospholipid translocase (flippase) Dnf1p; involved in translocation of phospholipids and alkylphosphocholine drugs across the plasma membrane"	1	0	0	0	0	0	0.35	0
4093_OG5_155061_7 - FUNGI_YOL078W	YOL078W	"AVO1 - Component of a membrane-bound complex containing the Tor2p kinase and other proteins, which may have a role in regulation of cell growth"	1	0	0	0	0	0	0.35	0
4094_OG5_155236_7 - FUNGI_YCR020C-A	YCR020C-A	MAK31 - Non-catalytic subunit of N-terminal acetyltransferase of the NatC type; required for replication of dsRNA virus; member of the Sm protein family	1	0	0	0	0	0	0.35	0
4095_OG5_155302_7 - FUNGI_YDR169C	YDR169C	"STB3 - Ribosomal RNA processing element (RRPE)-binding protein involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p"	1	0	0	0	0	0	0.35	0
4096_OG5_155322_7 - FUNGI_YOL067C	YOL067C	"RTG1 - Transcription factor (bHLH) involved in interorganelle communication between mitochondria, peroxisomes, and nucleus"	1	0	0	0	0	0	0.35	0
4097_OG5_155395_7 - FUNGI_YML041C	YML041C	"VPS71 - Nucleosome-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting"	1	0	0	0	0	0	0.35	0
4098_OG5_155398_7 - FUNGI_YNL136W	YNL136W	"EAF7 - Subunit of the NuA4 histone acetyltransferase complex, which acetylates the N-terminal tails of histones H4 and H2A"	1	0	0	0	0	0	0.35	0
4099_OG5_155445_7 - FUNGI_YLR181C	YLR181C	"VTA1 - Multivesicular body (MVB) protein involved in endosomal protein sorting; regulates Vps4p activity by promoting its oligomerization; has an N-terminal Vps60- and Did2- binding domain, a linker region, and a C-terminal Vps4p binding domain"	1	0	0	0	0	0	0.35	0
4100_OG5_155517_7 - FUNGI_YMR267W	YMR267W	"PPA2 - Mitochondrial inorganic pyrophosphatase, required for mitochondrial function and possibly involved in energy generation from inorganic pyrophosphate"	1	0	0	0	0	0	0.35	0
4101_OG5_155527_7 - FUNGI_YBL045C	YBL045C	"COR1 - Core subunit of the ubiquinol-cytochrome c reductase complex (bc1 complex), which is a component of the mitochondrial inner membrane electron transport chain"	1	0	0	0	0	0	0.35	0
4102_OG5_155578_7 - FUNGI_YPL179W	YPL179W	PPQ1 - Putative protein serine/threonine phosphatase; null mutation enhances efficiency of translational suppressors	1	0	0	0	0	0	0.35	0
4103_OG5_155601_7 - FUNGI_YNL309W	YNL309W	"STB1 - Protein with a role in regulation of MBF-specific transcription at Start, phosphorylated by Cln-Cdc28p kinases in vitro; unphosphorylated form binds Swi6p and binding is required for Stb1p function; expression is cell-cycle regulated"	1	0	0	0	0	0	0.35	0
4104_OG5_155604_7 - FUNGI_YER008C	YER008C	"SEC3 - Subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, Exo84p) which mediates targeting of post-Golgi vesicles to sites of active exocytosis; Sec3p specifically is a spatial landmark for secretion"	1	0	0	0	0	0	0.35	0
4105_OG5_155606_7 - FUNGI_YDL127W	YDL127W	"PCL2 - Cyclin, interacts with cyclin-dependent kinase Pho85p; member of the Pcl1,2-like subfamily, involved in the regulation of polarized growth and morphogenesis and progression through the cell cycle; localizes to sites of polarized cell growth"	1	0	0	0	0	0	0.35	0
4106_OG5_155609_7 - FUNGI_YBL086C	YBL086C	YBL086C - Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery	1	0	0	0	0	0	0.35	0
4107_OG5_155612_7 - FUNGI_YOR313C	YOR313C	SPS4 - Protein whose expression is induced during sporulation; not required for sporulation; heterologous expression in E. coli induces the SOS response that senses DNA damage	1	0	0	0	0	0	0.35	0
4108_OG5_155613_7 - FUNGI_YDR288W	YDR288W	NSE3 - Essential subunit of the Mms21-Smc5-Smc6 complex; protein of unknown function; required for DNA repair and growth	1	0	0	0	0	0	0.35	0
4109_OG5_155642_7 - FUNGI_YBL034C	YBL034C	STU1 - Component of the mitotic spindle that binds to interpolar microtubules via its association with beta-tubulin (Tub2p); required for interpolar microtubules to provide an outward force on the spindle poles	1	0	0	0	0	0	0.35	0
4110_OG5_155645_7 - FUNGI_YIL076W	YIL076W	"SEC28 - Epsilon-COP subunit of the coatomer; regulates retrograde Golgi-to-ER protein traffic; stabilizes Cop1p, the alpha-COP and the coatomer complex; non-essential for cell growth"	1	0	0	0	0	0	0.35	0
4111_OG5_155648_7 - FUNGI_YBR163W	YBR163W	"EXO5 - Mitochondrial 5'-3' exonuclease and sliding exonuclease, required for mitochondrial genome maintenance; distantly related to the RecB nuclease domain of bacterial RecBCD recombinases; may be regulated by the transcription factor Ace2"	1	0	0	0	0	0	0.35	0
4112_OG5_155652_7 - FUNGI_YML013W	YML013W	UBX2 - Protein involved in ER-associated protein degradation; proposed to coordinate the assembly of proteins involved in ERAD; contains a UBX (ubiquitin regulatory X) domain and a ubiquitin-associated (UBA) domain	1	0	0	0	0	0	0.35	0
4113_OG5_155661_7 - FUNGI_YDL160C-A	YDL160C-A	"YDL160C-A - Putative protein of unknown function; mutant in a srs2 mutant background displays MMS hypersensitivity; ortholog of human MHF2, a component of the Fanconi anemia (FA) complex that is involved in maintaining genome stability"	1	0	0	0	0	0	0.35	0
4114_OG5_155685_7 - FUNGI_YDR443C	YDR443C	SSN2 - Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for stable association of Srb10p-Srb11p kinase; essential for transcriptional regulation	1	0	0	0	0	0	0.35	0
4115_OG5_155695_7 - FUNGI_YNL054W	YNL054W	VAC7 - Integral vacuolar membrane protein involved in vacuole inheritance and morphology; activates Fab1p kinase activity under basal conditions and also after hyperosmotic shock	1	0	0	0	0	0	0.35	0
4116_OG5_155733_7 - FUNGI_YPL011C	YPL011C	"TAF3 - TFIID subunit (47 kDa), involved in promoter binding and RNA polymerase II transcription initiation"	1	0	0	0	0	0	0.35	0
4117_OG5_155735_7 - FUNGI_YIL026C	YIL026C	"IRR1 - Subunit of the cohesin complex, which is required for sister chromatid cohesion during mitosis and meiosis and interacts with centromeres and chromosome arms, essential for viability"	1	0	0	0	0	0	0.35	0
4118_OG5_155761_7 - FUNGI_YNL272C	YNL272C	"SEC2 - Guanyl-nucleotide exchange factor for the small G-protein Sec4p; essential for post-Golgi vesicle transport and for autophagy; associates with the exocyst, via exocyst subunit Sec15p, on secretory vesicles"	1	0	0	0	0	0	0.35	0
4119_OG5_155770_7 - FUNGI_YOR188W	YOR188W	"MSB1 - Protein involved in positive regulation of both 1,3-beta-glucan synthesis and the Pkc1p-MAPK pathway, potential Cdc28p substrate; multicopy suppressor of temperature-sensitive mutations in CDC24 and CDC42, and of mutations in BEM4"	1	0	0	0	0	0	0.35	0
4120_OG5_155773_7 - FUNGI_YKR020W	YKR020W	"VPS51 - Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; links the (VFT/GARP) complex to the SNARE Tlg1p"	1	0	0	0	0	0	0.35	0
4121_OG5_155775_7 - FUNGI_YPL024W	YPL024W	RMI1 - Subunit of the RecQ (Sgs1p) - Topo III (Top3p) complex; stimulates superhelical relaxing and ssDNA binding activities of Top3p; involved in response to DNA damage; null mutants display increased rates of recombination and delayed S phase	1	0	0	0	0	0	0.35	0
4122_OG5_155801_7 - FUNGI_YPR075C	YPR075C	OPY2 - Integral membrane protein that functions in the signaling branch of the high-osmolarity glycerol (HOG) pathway; interacts with Ste50p; overproduction blocks cell cycle arrest in the presence of mating pheromone	1	0	0	0	0	0	0.35	0
4123_OG5_155818_7 - FUNGI_YDL059C	YDL059C	RAD59 - Protein involved in the repair of double-strand breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; homologous to Rad52p	1	0	0	0	0	0	0.35	0
4124_OG5_155819_7 - FUNGI_YML031W	YML031W	"NDC1 - Nuclear envelope protein with multiple putative transmembrane domains, required for nuclear pore complex assembly and spindle pole body duplication; required for meiosis II"	1	0	0	0	0	0	0.35	0
4125_OG5_155820_7 - FUNGI_YOR353C	YOR353C	"SOG2 - Key component of the RAM signaling network, required for proper cell morphogenesis and cell separation after mitosis"	1	0	0	0	0	0	0.35	0
4126_OG5_155823_7 - FUNGI_YNL258C	YNL258C	DSL1 - Peripheral membrane protein needed for Golgi-to-ER retrograde traffic; forms a complex with Sec39p and Tip20p that interacts with ER SNAREs Sec20p and Use1p; component of the ER target site that interacts with coatomer; interacts with Cin5p	1	0	0	0	0	0	0.35	0
4127_OG5_155832_7 - FUNGI_YDR315C	YDR315C	"IPK1 - Inositol 1,3,4,5,6-pentakisphosphate 2-kinase, nuclear protein required for synthesis of 1,2,3,4,5,6-hexakisphosphate (phytate), which is integral to cell function; has 2 motifs conserved in other fungi; ipk1 gle1 double mutant is inviable"	1	0	0	0	0	0	0.35	0
4128_OG5_155873_7 - FUNGI_YFR032C	YFR032C	RRT5 - Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; expressed at high levels during sporulation	1	0	0	0	0	0	0.35	0
4129_OG5_155892_7 - FUNGI_YHR045W	YHR045W	YHR045W - Putative protein of unknown function; possible role in iron metabolism and/or amino acid and carbohydrate metabolism; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum	1	0	0	0	0	0	0.35	0
4130_OG5_155898_7 - FUNGI_YGR017W	YGR017W	YGR017W - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm	1	0	0	0	0	0	0.35	0
4131_OG5_155904_7 - FUNGI_YLR326W	YLR326W	"YLR326W - Putative protein of unknown function, predicted to be palmitoylated"	1	0	0	0	0	0	0.35	0
4132_OG5_155937_7 - FUNGI_YPR152C	YPR152C	URN1 - Putative protein of unknown function containing WW and FF domains; overexpression causes accumulation of cells in G1 phase	1	0	0	0	0	0	0.35	0
4133_OG5_155966_7 - FUNGI_YDL170W	YDL170W	"UGA3 - Transcriptional activator necessary for gamma-aminobutyrate (GABA)-dependent induction of GABA genes (such as UGA1, UGA2, UGA4); zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type; localized to the nucleus"	1	0	0	0	0	0	0.35	0
4134_OG5_155971_7 - FUNGI_YKR042W	YKR042W	"UTH1 - Mitochondrial outer membrane and cell wall localized SUN family member involved in cell wall biogenesis and required for mitochondrial autophagy; involved in the oxidative stress response, life span during starvation, and cell death"	1	0	0	0	0	0	0.35	0
4135_OG5_155976_7 - FUNGI_YNL103W	YNL103W	"MET4 - Leucine-zipper transcriptional activator, responsible for the regulation of the sulfur amino acid pathway, requires different combinations of the auxiliary factors Cbf1p, Met28p, Met31p and Met32p"	1	0	0	0	0	0	0.35	0
4136_OG5_155983_7 - FUNGI_YLL007C	YLL007C	YLL007C - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL007C is not an essential gene	1	0	0	0	0	0	0.35	0
4137_OG5_155989_7 - FUNGI_YDR181C	YDR181C	"SAS4 - Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which  acetylates free histones and nucleosomes and regulates transcriptional silencing; required for the HAT activity of Sas2p"	1	0	0	0	0	0	0.35	0
4138_OG5_156007_7 - FUNGI_YLR412W	YLR412W	"BER1 - Protein involved in microtubule-related processes, N-acetylation; GFP-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YLR412W is not an essential gene; similar to Arabidopsis SRR1 gene"	1	0	0	0	0	0	0.35	0
4139_OG5_156015_7 - FUNGI_YNL328C	YNL328C	MDJ2 - Constituent of the mitochondrial import motor associated with the presequence translocase; function overlaps with that of Pam18p; stimulates the ATPase activity of Ssc1p to drive mitochondrial import; contains a J domain	1	0	0	0	0	0	0.35	0
4140_OG5_156035_7 - FUNGI_YDR395W	YDR395W	"SXM1 - Nuclear transport factor (karyopherin) involved in protein transport between the cytoplasm and nucleoplasm; similar to Nmd5p, Cse1p, Lph2p, and the human cellular apoptosis susceptibility protein, CAS1"	1	0	0	0	0	0	0.35	0
4141_OG5_156095_7 - FUNGI_YOL070C	YOL070C	"NBA1 - Protein of unknown function, localizes to the bud neck and cytoplasm; interacts with Nap1p; may interact with ribosomes, based on co-purification experiments; potential Cdc28p substrate"	1	0	0	0	0	0	0.35	0
4142_OG5_156129_7 - FUNGI_YHR050W	YHR050W	SMF2 - Divalent metal ion transporter involved in manganese homeostasis; has broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins	1	0	0	0	0	0	0.35	0
4143_OG5_156139_7 - FUNGI_YOR349W	YOR349W	CIN1 - Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl	1	0	0	0	0	0	0.35	0
4144_OG5_156143_7 - FUNGI_YMR280C	YMR280C	"CAT8 - Zinc cluster transcriptional activator necessary for derepression of a variety of genes under non-fermentative growth conditions, active after diauxic shift, binds carbon source responsive elements"	1	0	0	0	0	0	0.35	0
4145_OG5_156152_7 - FUNGI_YIL027C	YIL027C	"KRE27 - Member of a transmembrane complex required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response, and also shows K1 killer toxin resistance"	1	0	0	0	0	0	0.35	0
4146_OG5_156160_7 - FUNGI_YDR206W	YDR206W	EBS1 - Protein involved in inhibition of translation and nonsense-mediated decay; interacts with cap binding protein Cdc33p and with Nam7p; localizes to P-bodies upon glucose starvation; mRNA abundance regulated by mRNA decay factors	1	0	0	0	0	0	0.35	0
4147_OG5_156166_7 - FUNGI_YER041W	YER041W	YEN1 - Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p	1	0	0	0	0	0	0.35	0
4148_OG5_156169_7 - FUNGI_YNL254C	YNL254C	RTC4 - Protein of unknown function; null mutation suppresses cdc13-1 temperature sensitivity; (GFP)-fusion protein localizes to both the cytoplasm and the nucleus	1	0	0	0	0	0	0.35	0
4149_OG5_156192_7 - FUNGI_YKL183W	YKL183W	LOT5 - Protein of unknown function; gene expression increases in cultures shifted to a lower temperature	1	0	0	0	0	0	0.35	0
4150_OG5_156197_7 - FUNGI_YGL079W	YGL079W	KXD1 - Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; null mutant is sensitive to drug inducing secretion of vacuolar cargo; GFP-fusion protein localizes to the endosome	1	0	0	0	0	0	0.35	0
4151_OG5_156201_7 - FUNGI_YBR120C	YBR120C	CBP6 - Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex	1	0	0	0	0	0	0.35	0
4152_OG5_156218_7 - FUNGI_YKL011C	YKL011C	"CCE1 - Mitochondrial cruciform cutting endonuclease, cleaves Holliday junctions formed during recombination of mitochondrial DNA"	1	0	0	0	0	0	0.35	0
4153_OG5_156225_7 - FUNGI_YNL236W	YNL236W	SIN4 - Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; contributes to both postive and negative transcriptional regulation; dispensible for basal transcription	1	0	0	0	0	0	0.35	0
4154_OG5_156228_7 - FUNGI_YMR179W	YMR179W	"SPT21 - Protein with a role in transcriptional silencing; required for normal transcription at several loci including HTA2-HTB2 and HHF2-HHT2, but not required at the other histone loci; functionally related to Spt10p"	1	0	0	0	0	0	0.35	0
4155_OG5_156258_7 - FUNGI_YIL036W	YIL036W	"CST6 - Basic leucine zipper (bZIP) transcription factor of the ATF/CREB family, proposed to be a regulator of oleate responsive genes; involved in utilization of non-optimal carbon sources and chromosome stability"	1	0	0	0	0	0	0.35	0
4156_OG5_156496_7 - FUNGI_YDR466W	YDR466W	"PKH3 - Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant"	1	0	0	0	0	0	0.35	0
4157_OG5_156599_7 - FUNGI_YHR049W	YHR049W	FSH1 - Putative serine hydrolase that localizes to both the nucleus and cytoplasm; sequence is similar to S. cerevisiae Fsh2p and Fsh3p and the human candidate tumor suppressor OVCA2	1	0	0	0	0	0	0.35	0
4158_OG5_156745_7 - FUNGI_YIR003W	YIR003W	AIM21 - Protein of unknown function involved in mitochondrial migration along actin filament; may interact with ribosomes; GFP-fusion protein colocalizes with Sac1p to the actin cytoskeleton	1	0	0	0	0	0	0.35	0
4159_OG5_156813_7 - FUNGI_YGL228W	YGL228W	SHE10 - Putative glycosylphosphatidylinositol (GPI)-anchored protein of unknown function; overexpression causes growth arrest	1	0	0	0	0	0	0.35	0.0625
4160_OG5_156957_7 - FUNGI_YPL269W	YPL269W	"KAR9 - Karyogamy protein required for correct positioning of the mitotic spindle and for orienting cytoplasmic microtubules, localizes at the shmoo tip in mating cells and at the tip of the growing bud in small-budded cells through anaphase"	1	0	0	0	0	0	0.35	0
4161_OG5_156959_7 - FUNGI_YLR021W	YLR021W	IRC25 - Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions	1	0	0	0	0	0	0.35	0
4162_OG5_156960_7 - FUNGI_YPL032C	YPL032C	"SVL3 - Protein of unknown function, mutant phenotype suggests a potential role in vacuolar function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck"	1	0	0	0	0	0	0.35	0
4163_OG5_156961_7 - FUNGI_YCL027W	YCL027W	"FUS1 - Membrane protein localized to the shmoo tip, required for cell fusion; expression regulated by mating pheromone; proposed to coordinate signaling, fusion, and polarization events required for fusion; potential Cdc28p substrate"	1	0	0	0	0	0	0.35	0
4164_OG5_156962_7 - FUNGI_YDR499W	YDR499W	LCD1 - Essential protein required for the DNA integrity checkpoint pathways; interacts physically with Mec1p; putative homolog of S. pombe Rad26 and human ATRIP	1	0	0	0	0	0	0.35	0
4165_OG5_156963_7 - FUNGI_YDR363W	YDR363W	"ESC2 - Sumo-like domain protein; prevents accumulation of toxic intermediates during replication-associated recombinational repair; roles in silencing, lifespan, chromatid cohesion and the intra-S-phase DNA damage checkpoint; RENi family member"	1	0	0	0	0	0	0.35	0
4166_OG5_156964_7 - FUNGI_YIL016W	YIL016W	SNL1 - Protein of unknown function proposed to be involved in nuclear pore complex biogenesis and maintenance as well as protein folding; has similarity to the mammalian BAG-1 protein	1	0	0	0	0	0	0.35	0
4167_OG5_156965_7 - FUNGI_YEL043W	YEL043W	"YEL043W - Predicted cytoskeleton protein involved in intracellular signalling based on quantitative analysis of protein-protein interaction maps; may interact with ribosomes, based on co-purification studies; contains fibronectin type III domain fold"	1	0	0	0	0	0	0.35	0
4168_OG5_156966_7 - FUNGI_YBL101C	YBL101C	ECM21 - Protein involved in regulating the endocytosis of plasma membrane proteins; identified as a substrate for ubiquitination by Rsp5p and deubiquitination by Ubp2p; promoter contains several Gcn4p binding elements	1	0	0	0	0	0	0.35	0
4169_OG5_156967_7 - FUNGI_YBR203W	YBR203W	"COS111 - Protein required for resistance to the antifungal drug ciclopirox olamine; not related to the subtelomerically-encoded COS family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"	1	0	0	0	0	0	0.35	0
4170_OG5_156968_7 - FUNGI_YER083C	YER083C	GET2 - Subunit of the GET complex; involved in insertion of proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for meiotic nuclear division	1	0	0	0	0	0	0.35	0
4171_OG5_156970_7 - FUNGI_YOR276W	YOR276W	"CAF20 - Phosphoprotein of the mRNA cap-binding complex involved in translational control, repressor of cap-dependent translation initiation, competes with eIF4G for binding to eIF4E"	1	0	0	0	0	0	0.35	0
4172_OG5_156971_7 - FUNGI_YJL103C	YJL103C	"GSM1 - Putative zinc cluster protein of unknown function; proposed to be involved in the regulation of energy metabolism, based on patterns of expression and sequence analysis"	1	0	0	0	0	0	0.35	0
4173_OG5_156972_7 - FUNGI_YKL018C-A	YKL018C-A	YKL018C-A - Putative protein of unknown function; identified by homology; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	1	0	0	0	0	0	0.35	0
4174_OG5_156973_7 - FUNGI_YGR134W	YGR134W	"CAF130 - Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation"	1	0	0	0	0	0	0.35	0
4175_OG5_156975_7 - FUNGI_YMR176W	YMR176W	"ECM5 - Non-essential protein of unknown function, contains ATP/GTP-binding site motif A; null mutant exhibits cellular volume up to four times greater than wild-type, also large drooping buds with elongated necks"	1	0	0	0	0	0	0.35	0
4176_OG5_156976_7 - FUNGI_YBR283C	YBR283C	SSH1 - Subunit of the Ssh1 translocon complex; Sec61p homolog involved in co-translational pathway of protein translocation; not essential	1	0	0	0	0	0	0.35	0
4177_OG5_156977_7 - FUNGI_YGR068C	YGR068C	ART5 - Protein proposed to regulate the endocytosis of plasma membrane proteins by recruiting the ubiquitin ligase Rsp5p to its target in the plasma membrane	1	0	0	0	0	0	0.35	0
4178_OG5_156978_7 - FUNGI_YPR034W	YPR034W	ARP7 - Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation	1	0	0	0	0	0	0.35	0
4179_OG5_156979_7 - FUNGI_YDR357C	YDR357C	CNL1 - Protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; null mutant is sensitive to drug inducing secretion of vacuolar cargo; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	1	0	0	0	0	0	0.35	0
4180_OG5_156980_7 - FUNGI_YJL184W	YJL184W	"GON7 - Component of the EKC/KEOPS protein complex with Kae1p, Cgi121p, Pcc1p, and Bud32p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription; implicated in osmotic stress response"	1	0	0	0	0	0	0.35	0
4181_OG5_156981_7 - FUNGI_YKR055W	YKR055W	"RHO4 - Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely to be involved in the establishment of cell polarity"	1	0	0	0	0	0	0.35	0
4182_OG5_156985_7 - FUNGI_YER137C	YER137C	YER137C - Putative protein of unknown function	1	0	0	0	0	0	0.35	0
4183_OG5_156986_7 - FUNGI_YBL025W	YBL025W	"RRN10 - Protein involved in promoting high level transcription of rDNA, subunit of UAF (upstream activation factor) for RNA polymerase I"	1	0	0	0	0	0	0.35	0
4184_OG5_156988_7 - FUNGI_YFR040W	YFR040W	"SAP155 - Protein that forms a complex with the Sit4p protein phosphatase and is required for its function; member of a family of similar proteins including Sap4p, Sap185p, and Sap190p"	1	0	0	0	0	0	0.35	0
4185_OG5_156989_7 - FUNGI_YML108W	YML108W	YML108W - Putative protein of unknown function whose structure defines a new subfamily of the split beta-alpha-beta sandwiches; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YML108W is not an essential gene	1	0	0	0	0	0	0.35	0
4186_OG5_156990_7 - FUNGI_YML043C	YML043C	"RRN11 - Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p"	1	0	0	0	0	0	0.35	0
4187_OG5_156992_7 - FUNGI_YDR380W	YDR380W	"ARO10 - Phenylpyruvate decarboxylase, catalyzes decarboxylation of phenylpyruvate to phenylacetaldehyde, which is the first specific step in the Ehrlich pathway"	1	0	0	0	0	0	0.35	0
4188_OG5_156995_7 - FUNGI_YHR109W	YHR109W	"CTM1 - Cytochrome c lysine methyltransferase, trimethylates residue 72 of apo-cytochrome c (Cyc1p) in the cytosol; not required for normal respiratory growth"	1	0	0	0	0	0	0.35	0
4189_OG5_156996_7 - FUNGI_YKR004C	YKR004C	ECM9 - Non-essential protein of unknown function	1	0	0	0	0	0	0.35	0
4190_OG5_156997_7 - FUNGI_YDR480W	YDR480W	"DIG2 - MAP kinase-responsive inhibitor of the Ste12p transcription factor, involved in the regulation of mating-specific genes and the invasive growth pathway; related regulators Dig1p and Dig2p bind to Ste12p"	1	0	0	0	0	0	0.35	0
4191_OG5_156998_7 - FUNGI_YMR256C	YMR256C	"COX7 - Subunit VII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain"	1	0	0	0	0	0	0.35	0
4192_OG5_156999_7 - FUNGI_YPL194W	YPL194W	"DDC1 - DNA damage checkpoint protein, part of a PCNA-like complex required for DNA damage response, required for pachytene checkpoint to inhibit cell cycle in response to unrepaired recombination intermediates; potential Cdc28p substrate"	1	0	0	0	0	0	0.35	0
4193_OG5_157000_7 - FUNGI_YDR295C	YDR295C	HDA2 - Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex containing an Hda1p homodimer and an Hda2p-Hda3p heterodimer; involved in telomere maintenance	1	0	0	0	0	0	0.35	0
4194_OG5_157002_7 - FUNGI_YER024W	YER024W	"YAT2 - Carnitine acetyltransferase; has similarity to Yat1p, which is a carnitine acetyltransferase associated with the mitochondrial outer membrane"	1	0	0	0	0	0	0.35	0
4195_OG5_157003_7 - FUNGI_YDL025C	YDL025C	"RTK1 - Putative protein kinase, potentially phosphorylated by Cdc28p; interacts with ribosome biogenesis factors, Cka2, Gus1 and Arc1"	1	0	0	0	0	0	0.35	0
4196_OG5_157004_7 - FUNGI_YJL131C	YJL131C	"AIM23 - Putative protein of unknown function; the authentic non-tagged protein is detected in highly purified mitochondria; null mutant is viable, displays severe respiratory growth defect and elevated frequency of mitochondrial genome loss"	1	0	0	0	0	0	0.35	0
4197_OG5_157005_7 - FUNGI_YDR184C	YDR184C	"ATC1 - Nuclear protein, possibly involved in regulation of cation stress responses and/or in the establishment of bipolar budding pattern"	1	0	0	0	0	0	0.35	0
4198_OG5_157006_7 - FUNGI_YLR165C	YLR165C	"PUS5 - Pseudouridine synthase, catalyzes only the formation of pseudouridine (Psi)-2819 in mitochondrial 21S rRNA; not essential for viability"	1	0	0	0	0	0	0.35	0
4199_OG5_157007_7 - FUNGI_YMR086W	YMR086W	"YMR086W - Component of the eisosome with unknown function; may interact with ribosomes, based on co-purification experiments; GFP-fusion protein localizes to the cell periphery; expression is repressed by cAMP"	1	0	0	0	0	0	0.35	0
4200_OG5_157008_7 - FUNGI_YCR081W	YCR081W	SRB8 - Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; involved in glucose repression	1	0	0	0	0	0	0.35	0
4201_OG5_157009_7 - FUNGI_YKR100C	YKR100C	SKG1 - Transmembrane protein with a role in cell wall polymer composition; localizes on the inner surface of the plasma membrane at the bud and in the daughter cell	1	0	0	0	0	0	0.35	0
4202_OG5_157010_7 - FUNGI_YKL142W	YKL142W	MRP8 - Protein of unknown function; undergoes sumoylation; transcription induced under cell wall stress; protein levels are reduced under anaerobic conditions; originally thought to be a mitochondrial ribosomal protein based on sequence analysis	1	0	0	0	0	0	0.35	0
4203_OG5_157011_7 - FUNGI_YDR216W	YDR216W	"ADR1 - Carbon source-responsive zinc-finger transcription factor, required for transcription of the glucose-repressed gene ADH2, of peroxisomal protein genes, and of genes required for ethanol, glycerol, and fatty acid utilization"	1	0	0	0	0	0	0.35	0
4204_OG5_157014_7 - FUNGI_YHL019C	YHL019C	"APM2 - Protein of unknown function, homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport"	1	0	0	0	0	0	0.35	0
4205_OG5_157015_7 - FUNGI_YKL137W	YKL137W	"CMC1 - Evolutionarily conserved copper-binding protein of the mitochondrial intermembrane space, may be involved in delivering copper from the matrix to the cytochrome c oxidase complex; contains a twin CX9C motif"	1	0	0	0	0	0	0.35	0
4206_OG5_157016_7 - FUNGI_YBR138C	YBR138C	"YBR138C - Cytoplasmic protein of unknown function, potentially phosphorylated by Cdc28p; YBR138C is not an essential gene"	1	0	0	0	0	0	0.35	0
4207_OG5_157017_7 - FUNGI_YMR157C	YMR157C	"AIM36 - Protein of unknown function; null mutant displays reduced respiratory growth and elevated frequency of mitochondrial genome loss; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies"	1	0	0	0	0	0	0.35	0
4208_OG5_157018_7 - FUNGI_YOR030W	YOR030W	"DFG16 - Probable multiple transmembrane protein, involved in diploid invasive and pseudohyphal growth upon nitrogen starvation; required for accumulation of processed Rim101p"	1	0	0	0	0	0	0.35	0
4209_OG5_157019_7 - FUNGI_YKL176C	YKL176C	LST4 - Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface	1	0	0	0	0	0	0.35	0
4210_OG5_157020_7 - FUNGI_YKL171W	YKL171W	"NNK1 - Protein kinase; implicated in proteasome function; interacts with TORC1, Ure2 and Gdh2; overexpression leads to hypersensitivity to rapamycin and nuclear accumulation of Gln3; epitope-tagged protein localizes to the cytoplasm"	1	0	0	0	0	0	0.35	0
4211_OG5_157022_7 - FUNGI_YFL029C	YFL029C	"CAK1 - Cyclin-dependent kinase-activating kinase required for passage through the cell cycle, phosphorylates and activates Cdc28p; nucleotide-binding pocket differs significantly from those of most other protein kinases"	1	0	0	0	0	0	0.35	0
4212_OG5_157024_7 - FUNGI_YOR060C	YOR060C	SLD7 - Protein with a role in chromosomal DNA replication; interacts with Sld3p and reduces its affinity for Cdc45p; deletion mutant has aberrant mitochondria	1	0	0	0	0	0	0.35	0
4213_OG5_157025_7 - FUNGI_YMR124W	YMR124W	"YMR124W - Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization"	1	0	0	0	0	0	0.35	0
4214_OG5_157026_7 - FUNGI_YLR395C	YLR395C	"COX8 - Subunit VIII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain"	1	0	0	0	0	0	0.35	0
4215_OG5_157027_7 - FUNGI_YLR288C	YLR288C	"MEC3 - DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1"	1	0	0	0	0	0	0.35	0
4216_OG5_157028_7 - FUNGI_YML117W	YML117W	NAB6 - Putative RNA-binding protein that associates with mRNAs encoding cell wall proteins in high-throughput studies; deletion mutants display increased sensitivity to some cell wall disrupting agents; expression negatively regulated by cAMP	1	0	0	0	0	0	0.35	0
4217_OG5_157031_7 - FUNGI_YAL040C	YAL040C	"CLN3 - G1 cyclin involved in cell cycle progression; activates Cdc28p kinase to promote the G1 to S phase transition; plays a role in regulating transcription of the other G1 cyclins, CLN1 and CLN2; regulated by phosphorylation and proteolysis"	1	0	0	0	0	0	0.35	0
4218_OG5_157033_7 - FUNGI_YKL090W	YKL090W	"CUE2 - Protein of unknown function; has two CUE domains that bind ubiquitin, which may facilitate intramolecular monoubiquitination"	1	0	0	0	0	0	0.35	0
4219_OG5_157034_7 - FUNGI_YLR139C	YLR139C	SLS1 - Mitochondrial membrane protein that coordinates expression of mitochondrially-encoded genes; may facilitate delivery of mRNA to membrane-bound translation machinery	1	0	0	0	0	0	0.35	0
4220_OG5_157035_7 - FUNGI_YDR217C	YDR217C	"RAD9 - DNA damage-dependent checkpoint protein, required for cell-cycle arrest in G1/S, intra-S, and G2/M; transmits checkpoint signal by activating Rad53p and Chk1p; hyperphosphorylated by Mec1p and Tel1p; potential Cdc28p substrate"	1	0	0	0	0	0	0.35	0
4221_OG5_157036_7 - FUNGI_YOR026W	YOR026W	"BUB3 - Kinetochore checkpoint WD40 repeat protein that localizes to kinetochores during prophase and metaphase, delays anaphase in the presence of unattached kinetochores; forms complexes with Mad1p-Bub1p and with Cdc20p, binds Mad2p and Mad3p"	1	0	0	0	0	0	0.35	0
4222_OG5_157038_7 - FUNGI_YGR237C	YGR237C	YGR237C - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	1	0	0	0	0	0	0.35	0
4223_OG5_157039_7 - FUNGI_YNL086W	YNL086W	SNN1 - Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to endosomes	1	0	0	0	0	0	0.35	0
4224_OG5_157040_7 - FUNGI_YHL014C	YHL014C	"YLF2 - Protein of unknown function, has weak similarity to E. coli GTP-binding protein gtp1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"	1	0	0	0	0	0	0.35	0
4225_OG5_157041_7 - FUNGI_YGR030C	YGR030C	"POP6 - Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs"	1	0	0	0	0	0	0.35	0
4226_OG5_157042_7 - FUNGI_YIL137C	YIL137C	TMA108 - Protein that associates with ribosomes and is involved in ribosome biogenesis; putative metalloprotease	1	0	0	0	0	0	0.35	0
4227_OG5_157044_7 - FUNGI_YPR085C	YPR085C	"ASA1 - Putative protein of unknown function; subunit of the ASTRA complex (Rvb1p, Rvb2p, Tra1p, Tti1p, Tti2, Asa1p and Tra1p) which is part of the chromatin remodeling machinery"	1	0	0	0	0	0	0.35	0
4228_OG5_157045_7 - FUNGI_YDR202C	YDR202C	"RAV2 - Subunit of RAVE (Rav1p, Rav2p, Skp1p), a complex that associates with the V1 domain of the vacuolar membrane (H+)-ATPase (V-ATPase) and promotes assembly and reassembly of the holoenzyme"	1	0	0	0	0	0	0.35	0
4229_OG5_157046_7 - FUNGI_YPL112C	YPL112C	"PEX25 - Peripheral peroxisomal membrane peroxin required for the regulation of peroxisome size and maintenance, recruits GTPase Rho1p to peroxisomes, induced by oleate, interacts with homologous protein Pex27p"	1	0	0	0	0	0	0.35	0
4230_OG5_157048_7 - FUNGI_YJL122W	YJL122W	ALB1 - Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit; interacts directly with Arx1p; responsible for Tif6p recycling defects in absence of Rei1p	1	0	0	0	0	0	0.35	0
4231_OG5_157049_7 - FUNGI_YAL047C	YAL047C	"SPC72 - Component of the cytoplasmic Tub4p (gamma-tubulin) complex, binds spindle pole bodies and links them to microtubules; has roles in astral microtubule formation and stabilization"	1	0	0	0	0	0	0.35	0
4232_OG5_157050_7 - FUNGI_YOR220W	YOR220W	RCN2 - Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; phosphorylated in response to alpha factor	1	0	0	0	0	0	0.35	0
4233_OG5_157051_7 - FUNGI_YKL124W	YKL124W	"SSH4 - Specificity factor required for Rsp5p-dependent ubiquitination and sorting of cargo proteins at the multivesicular body; identified as a high-copy suppressor of a SHR3 deletion, increasing steady-state levels of amino acid permeases"	1	0	0	0	0	0	0.35	0
4234_OG5_157052_7 - FUNGI_YMR258C	YMR258C	ROY1 - GTPase inhibitor with similarity to F-box proteins; inhibits Ypt52p GTPase activity by preventing Ypt52p from binding GTP; involved in regulating intracellular trafficking; physically interacts with Skp1p	1	0	0	0	0	0	0.35	0
4235_OG5_157054_7 - FUNGI_YJL117W	YJL117W	"PHO86 - Endoplasmic reticulum (ER) resident protein required for ER exit of the high-affinity phosphate transporter Pho84p, specifically required for packaging of Pho84p into COPII vesicles"	1	0	0	0	0	0	0.35	0
4236_OG5_157056_7 - FUNGI_YDR279W	YDR279W	"RNH202 - Ribonuclease H2 subunit, required for RNase H2 activity; related to human AGS2 that causes Aicardi-Goutieres syndrome"	1	0	0	0	0	0	0.35	0
4237_OG5_157057_7 - FUNGI_YGR102C	YGR102C	YGR102C - Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria	1	0	0	0	0	0	0.35	0
4238_OG5_157058_7 - FUNGI_YNL216W	YNL216W	"RAP1 - DNA-binding protein involved in either activation or repression of transcription, depending on binding site context; also binds telomere sequences and plays a role in telomeric position effect (silencing) and telomere structure"	1	0	0	0	0	0	0.35	0
4239_OG5_157059_7 - FUNGI_YKL186C	YKL186C	"MTR2 - mRNA transport regulator, essential nuclear protein; Mex67p and Mtr2p form a mRNA export complex which binds to RNA"	1	0	0	0	0	0	0.35	0
4240_OG5_159235_7 - FUNGI_YIL030C	YIL030C	SSM4 - Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation	1	0	0	0	0	0	0.35	0
4241_OG5_159833_7 - FUNGI_YMR044W	YMR044W	"IOC4 - Member of a complex (Isw1b) with Isw1p and Ioc2p that exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing, contains a PWWP motif"	1	0	0	0	0	0	0.35	0
4242_OG5_159920_7 - FUNGI_YGR042W	YGR042W	YGR042W - Putative protein of unknown function; involved in maintenance of proper telomere length; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus	1	0	0	0	0	0	0.35	0
4243_OG5_160793_7 - FUNGI_YAL055W	YAL055W	"PEX22 - Putative peroxisomal membrane protein required for import of peroxisomal proteins, functionally complements a Pichia pastoris pex22 mutation"	1	0	0	0	0	0	0.35	0
4244_OG5_160795_7 - FUNGI_YNR022C	YNR022C	"MRPL50 - Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation"	1	0	0	0	0	0	0.35	0
4245_OG5_160797_7 - FUNGI_YER071C	YER071C	TDA2 - Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; null mutant is sensitive to expression of the top1-T722A allele	1	0	0	0	0	0	0.35	0
4246_OG5_160798_7 - FUNGI_YLR390W	YLR390W	"ECM19 - Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"	1	0	0	0	0	0	0.35	0
4247_OG5_160799_7 - FUNGI_YOR352W	YOR352W	"YOR352W - Putative protein of unknown function; expression levels regulated by Arg5,6p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus"	1	0	0	0	0	0	0.35	0
4248_OG5_142628_7 - FUNGI_YKR090W	YKR090W	"PXL1 - LIM domain-containing protein that localizes to sites of polarized growth, required for selection and/or maintenance of polarized growth sites, may modulate signaling by the GTPases Cdc42p and Rho1p; has similarity to metazoan paxillin"	1	0	0	0	0.142857143	0.071428571	0.35	0
4249_OG5_135612_7 - FUNGI_YNL281W	YNL281W	HCH1 - Heat shock protein regulator that binds to Hsp90p and may stimulate ATPase activity; originally identified as a high-copy number suppressor of a HSP90 loss-of-function mutation; GFP-fusion protein localizes to the cytoplasm and nucleus	1	0	0	0.125	0.095238095	0	0.35	0.3125
4250_OG5_149763_7 - FUNGI_YJL042W	YJL042W	MHP1 - Microtubule-associated protein involved in assembly and stabilization of microtubules; overproduction results in cell cycle arrest at G2 phase; similar to Drosophila protein MAP and to mammalian MAP4 proteins	1	0	0	0	0.047619048	0.071428571	0.35	0
4251_OG5_149796_7 - FUNGI_YDL233W	YDL233W	YDL233W - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YDL233W is not an essential gene	1	0	0	0	0.047619048	0.071428571	0.35	0
4252_OG5_144812_7 - FUNGI_YIL011W	YIL011W	TIR3 - Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth	1	0	0	0.125	0	0.071428571	0.35	0
4253_OG5_144812_7 - FUNGI_YBR067C	YBR067C	TIP1 - Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins	1	0	0	0.125	0	0.071428571	0.35	0
4254_OG5_147436_7 - FUNGI_YMR198W	YMR198W	"CIK1 - Kinesin-associated protein required for both karyogamy and mitotic spindle organization, interacts stably and specifically with Kar3p and may function to target this kinesin to a specific cellular role; has similarity to Vik1p"	1	0	0	0.125	0	0	0.35	0
4255_OG5_147436_7 - FUNGI_YPL253C	YPL253C	"VIK1 - Protein that forms a complex with Kar3p at the spindle pole body, possible regulator of Kar3p function in microtubule-mediated processes; required for sister chromatid cohesion; has similarity to Cik1p"	1	0	0	0.125	0	0	0.35	0
4256_OG5_149475_7 - FUNGI_YML017W	YML017W	PSP2 - Asn rich cytoplasmic protein that contains RGG motifs; high-copy suppressor of group II intron-splicing defects of a mutation in MRS2 and of a conditional mutation in POL1 (DNA polymerase alpha); possible role in mitochondrial mRNA splicing	1	0	0	0.125	0	0	0.35	0
4257_OG5_152524_7 - FUNGI_YLL056C	YLL056C	"YLL056C - Putative protein of unknown function, transcription is activated by paralogous transcription factors Yrm1p and Yrr1p and genes involved in pleiotropic drug resistance (PDR); expression is induced in cells treated with the mycotoxin patulin"	1	0	0	0.125	0	0	0.35	0
4258_OG5_152827_7 - FUNGI_YIL031W	YIL031W	"ULP2 - Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins, plays a role in chromosome cohesion at centromeric regions and recovery from checkpoint arrest induced by DNA damage or DNA replication defects; potential Cdc28p substrate"	1	0	0	0.125	0	0	0.35	0
4259_OG5_153049_7 - FUNGI_YHR197W	YHR197W	"RIX1 - Essential component of the Rix1 complex (Rix1p, Ipi1p, Ipi3p) that is required for processing of ITS2 sequences from 35S pre-rRNA; Rix1 complex associates with Mdn1p in pre-60S ribosomal particles"	1	0	0	0.125	0	0	0.35	0
4260_OG5_153069_7 - FUNGI_YML019W	YML019W	"OST6 - Subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; similar to and partially functionally redundant with Ost3p"	1	0	0	0.125	0	0	0.35	0
4261_OG5_144167_7 - FUNGI_YMR070W	YMR070W	"MOT3 - Nuclear transcription factor with two Cys2-His2 zinc fingers; involved in repression of a subset of hypoxic genes by Rox1p, repression of several DAN/TIR genes during aerobic growth, and repression of ergosterol biosynthetic genes"	1	0	0	0	0.047619048	0	0.3	0.0625
4262_OG5_153023_7 - FUNGI_Q0140	Q0140	"VAR1 - Mitochondrial ribosomal protein of the small subunit, mitochondrially-encoded; polymorphic in different strains due to variation in number of AAT (asparagine) codons; translated near the mitochondrial inner membrane"	1	0	0	0	0.047619048	0	0.3	0.0625
4263_OG5_156072_7 - FUNGI_YHR137W	YHR137W	"ARO9 - Aromatic aminotransferase II, catalyzes the first step of tryptophan, phenylalanine, and tyrosine catabolism"	1	0	0	0	0.047619048	0	0.3	0
4264_OG5_156209_7 - FUNGI_YMR172W	YMR172W	HOT1 - Transcription factor required for the transient induction of glycerol biosynthetic genes GPD1 and GPP2 in response to high osmolarity; targets Hog1p to osmostress responsive promoters; has similarity to Msn1p and Gcr1p	1	0	0	0	0.047619048	0	0.3	0
4265_OG5_156940_7 - FUNGI_YCR054C	YCR054C	CTR86 - Essential protein of unknown function; upstream region contains a Gcn4p responsive site suggesting a possible role in amino acid biosynthesis	1	0	0	0	0.047619048	0	0.3	0
4266_OG5_156982_7 - FUNGI_YGR161C	YGR161C	RTS3 - Putative component of the protein phosphatase type 2A complex	1	0	0	0	0.047619048	0	0.3	0
4267_OG5_157012_7 - FUNGI_YHR159W	YHR159W	TDA11 - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; potential Cdc28p substrate; null mutant is sensitive to expression of the top1-T722A allele	1	0	0	0	0.047619048	0	0.3	0
4268_OG5_161406_7 - FUNGI_YGR059W	YGR059W	SPR3 - Sporulation-specific homolog of the yeast CDC3/10/11/12 family of bud neck microfilament genes; septin protein involved in sporulation; regulated by ABFI	1	0	0.027777778	0	0	0	0.3	0
4269_OG5_150101_7 - FUNGI_YKL222C	YKL222C	"YKL222C - Protein of unknown function that may interact with ribosomes, based on co-purification experiments; similar to transcriptional regulators from the zinc cluster (binuclear cluster) family; null mutant is sensitive to caffeine"	1	0	0	0	0	0	0.3	0
4270_OG5_150101_7 - FUNGI_YOR162C	YOR162C	"YRR1 - Zn2-Cys6 zinc-finger transcription factor that activates genes involved in multidrug resistance; paralog of Yrm1p, acting on an overlapping set of target genes"	1	0	0	0	0	0	0.3	0
4271_OG5_150101_7 - FUNGI_YOR172W	YOR172W	"YRM1 - Zn2-Cys6 zinc-finger transcription factor that activates genes involved in multidrug resistance; paralog of Yrr1p, acting on an overlapping set of target genes"	1	0	0	0	0	0	0.3	0
4272_OG5_152982_7 - FUNGI_YDR043C	YDR043C	NRG1 - Transcriptional repressor that recruits the Cyc8p-Tup1p complex to promoters; mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH response	1	0	0	0	0	0	0.3	0
4273_OG5_152982_7 - FUNGI_YBR066C	YBR066C	NRG2 - Transcriptional repressor that mediates glucose repression and negatively regulates filamentous growth; has similarity to Nrg1p	1	0	0	0	0	0	0.3	0
4274_OG5_153062_7 - FUNGI_YBR149W	YBR149W	"ARA1 - NADP+ dependent arabinose dehydrogenase, involved in carbohydrate metabolism; purified as homodimer; naturally occurs with a N-terminus degradation product"	1	0	0	0	0	0	0.3	0
4275_OG5_153155_7 - FUNGI_YDR125C	YDR125C	"ECM18 - Protein of unknown function, similar to Rlp24p"	1	0	0	0	0	0	0.3	0
4276_OG5_153718_7 - FUNGI_YDR072C	YDR072C	"IPT1 - Inositolphosphotransferase, involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), the most abundant sphingolipid;, can mutate to resistance to the antifungals syringomycin E and DmAMP1 and to K. lactis zymocin"	1	0	0	0	0	0	0.3	0
4277_OG5_155152_7 - FUNGI_YCL002C	YCL002C	YCL002C - Putative protein of unknown function; YCL002C is not an essential gene	1	0	0	0	0	0	0.3	0
4278_OG5_156171_7 - FUNGI_YOL089C	YOL089C	HAL9 - Putative transcription factor containing a zinc finger; overexpression increases salt tolerance through increased expression of the ENA1 (Na+/Li+ extrusion pump) gene while gene disruption decreases both salt tolerance and ENA1 expression	1	0	0	0	0	0	0.3	0
4279_OG5_158495_7 - FUNGI_YKR095W-A	YKR095W-A	"PCC1 - Component of the EKC/KEOPS protein complex with Kae1p, Gon7p, Bud32p, and Cgi121p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription"	1	0	0	0	0	0	0.3	0
4280_OG5_158836_7 - FUNGI_YOR032C	YOR032C	HMS1 - Basic helix-loop-helix (bHLH) protein with similarity to myc-family transcription factors; overexpression confers hyperfilamentous growth and suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant	1	0	0	0	0	0	0.3	0
4281_OG5_158843_7 - FUNGI_YMR067C	YMR067C	UBX4 - UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p	1	0	0	0	0	0	0.3	0
4282_OG5_158887_7 - FUNGI_YGL154C	YGL154C	LYS5 - Phosphopantetheinyl transferase involved in lysine biosynthesis; converts inactive apo-form of Lys2p (alpha-aminoadipate reductase) into catalytically active holo-form by posttranslational addition of phosphopantetheine	1	0	0	0	0	0	0.3	0
4283_OG5_158990_7 - FUNGI_YOR273C	YOR273C	"TPO4 - Polyamine transport protein, recognizes spermine, putrescine, and spermidine; localizes to the plasma membrane; member of the major facilitator superfamily"	1	0	0	0	0	0	0.3	0
4284_OG5_159336_7 - FUNGI_YMR291W	YMR291W	TDA1 - Putative kinase of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene	1	0	0	0	0	0	0.3	0
4285_OG5_159361_7 - FUNGI_YOR094W	YOR094W	"ARF3 - Glucose-repressible ADP-ribosylation factor, GTPase of the Ras superfamily involved in development of polarity; also has mRNA binding activity"	1	0	0	0	0	0	0.3	0
4286_OG5_159436_7 - FUNGI_YNL152W	YNL152W	"INN1 - Essential protein that associates with the contractile actomyosin ring, required for ingression of the plasma membrane into the bud neck during cytokinesis; C2 domain, a membrane targeting module, is required for function"	1	0	0	0	0	0	0.3	0
4287_OG5_159610_7 - FUNGI_YLR363C	YLR363C	"NMD4 - Protein interacting with Nam7p, may be involved in the nonsense-mediated mRNA decay pathway"	1	0	0	0	0	0	0.3	0
4288_OG5_159763_7 - FUNGI_YHR182W	YHR182W	YHR182W - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and cytoplasm	1	0	0	0	0	0	0.3	0
4289_OG5_159801_7 - FUNGI_YOR368W	YOR368W	"RAD17 - Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; with Mec3p and Ddc1p, forms a clamp that is loaded onto partial duplex DNA; homolog of human and S. pombe Rad1 and U. maydis Rec1 proteins"	1	0	0	0	0	0	0.3	0
4290_OG5_159826_7 - FUNGI_YOR138C	YOR138C	"RUP1 - Protein involved in regulation of Rsp5p, which is an essential HECT ubiquitin ligase; has a WW domain consensus motif of PPPSY (residues 131-135) that mediates binding of Rsp5p to Ubp2p; contains an UBA domain"	1	0	0	0	0	0	0.3	0
4291_OG5_159836_7 - FUNGI_YMR019W	YMR019W	STB4 - Protein that binds Sin3p in a two-hybrid assay; contains a Zn(II)2Cys6 zinc finger domain characteristic of DNA-binding proteins; computational analysis suggests a role in regulation of expression of genes encoding transporters	1	0	0	0	0	0	0.3	0
4292_OG5_159868_7 - FUNGI_YOR084W	YOR084W	"LPX1 - Oleic acid-inducible, peroxisomal matrix localized lipase; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; peroxisomal import is dependent on the PTS1 receptor, Pex5p and on self-interaction"	1	0	0	0	0	0	0.3	0
4293_OG5_160756_7 - FUNGI_YPR054W	YPR054W	SMK1 - Middle sporulation-specific mitogen-activated protein kinase (MAPK) required for production of the outer spore wall layers; negatively regulates activity of the glucan synthase subunit Gsc2p	1	0	0	0	0	0	0.3	0
4294_OG5_160757_7 - FUNGI_YEL059C-A	YEL059C-A	"SOM1 - Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs"	1	0	0	0	0	0	0.3	0
4295_OG5_160762_7 - FUNGI_YLR343W	YLR343W	"GAS2 - 1,3-beta-glucanosyltransferase, involved with Gas4p in spore wall assembly; has similarity to Gas1p"	1	0	0	0	0	0	0.3	0
4296_OG5_160764_7 - FUNGI_YNL149C	YNL149C	PGA2 - Essential protein required for maturation of Gas1p and Pho8p; involved in protein trafficking; GFP-fusion protein localizes to the ER and YFP-fusion protein to the nuclear envelope-ER network; null mutants have a cell separation defect	1	0	0	0	0	0	0.3	0
4297_OG5_160767_7 - FUNGI_YPR084W	YPR084W	YPR084W - Putative protein of unknown function	1	0	0	0	0	0	0.3	0
4298_OG5_160771_7 - FUNGI_YPR017C	YPR017C	"DSS4 - Guanine nucleotide dissociation stimulator for Sec4p, functions in the post-Golgi secretory pathway; binds zinc, found both on membranes and in the cytosol"	1	0	0	0	0	0	0.3	0
4299_OG5_160780_7 - FUNGI_YJR003C	YJR003C	YJR003C - Putative protein of unknown function; detected in highly purified mitochondria in high-throughput studies; predicted to be involved in ribosome biogenesis	1	0	0	0	0	0	0.3	0
4300_OG5_160782_7 - FUNGI_YDR207C	YDR207C	"UME6 - Key transcriptional regulator of early meiotic genes, binds URS1 upstream regulatory sequence, couples metabolic responses to nutritional cues with initiation and progression of meiosis, forms complex with Ime1p, and also with Sin3p-Rpd3p"	1	0	0	0	0	0	0.3	0
4301_OG5_160788_7 - FUNGI_YGR249W	YGR249W	MGA1 - Protein similar to heat shock transcription factor; multicopy suppressor of pseudohyphal growth defects of ammonium permease mutants	1	0	0	0	0	0	0.3	0
4302_OG5_160917_7 - FUNGI_YIL135C	YIL135C	"VHS2 - Cytoplasmic protein of unknown function; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; similar to Mlf3p"	1	0	0	0	0	0	0.3	0
4303_OG5_160917_7 - FUNGI_YNL074C	YNL074C	"MLF3 - Serine-rich protein of unknown function, predicted to be palmitoylated; overproduction suppresses the growth inhibition caused by exposure to the immunosuppressant leflunomide"	1	0	0	0	0	0	0.3	0
4304_OG5_162728_7 - FUNGI_YOL116W	YOL116W	"MSN1 - Transcriptional activator involved in regulation of invertase and glucoamylase expression, invasive growth and pseudohyphal differentiation, iron uptake, chromium accumulation, and response to osmotic stress; localizes to the nucleus"	1	0	0	0	0	0	0.3	0
4305_OG5_163610_7 - FUNGI_YMR319C	YMR319C	FET4 - Low-affinity Fe(II) transporter of the plasma membrane	1	0	0	0	0	0	0.3	0
4306_OG5_163783_7 - FUNGI_YDL139C	YDL139C	"SCM3 - Nonhistone component of centromeric chromatin that binds stoichiometrically to CenH3-H4 histones, required for kinetochore assembly; required for G2/M progression and localization of Cse4p; may protect Cse4p from ubiquitylation"	1	0	0	0	0	0	0.3	0
4307_OG5_164015_7 - FUNGI_YBL018C	YBL018C	"POP8 - Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs"	1	0	0	0	0	0	0.3	0
4308_OG5_164105_7 - FUNGI_YGL025C	YGL025C	PGD1 - Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for basal and activated transcription; direct target of Cyc8p-Tup1p transcriptional corepressor	1	0	0	0	0	0	0.3	0
4309_OG5_164147_7 - FUNGI_YJR004C	YJR004C	"SAG1 - Alpha-agglutinin of alpha-cells, binds to Aga1p during agglutination, N-terminal half is homologous to the immunoglobulin superfamily and contains binding site for a-agglutinin, C-terminal half is highly glycosylated and contains GPI anchor"	1	0	0	0	0	0	0.3	0
4310_OG5_164519_7 - FUNGI_YGL140C	YGL140C	YGL140C - Putative protein of unknown function; non-essential gene; contains multiple predicted transmembrane domains	1	0	0	0	0	0	0.3	0
4311_OG5_165229_7 - FUNGI_YHR196W	YHR196W	"UTP9 - Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA"	1	0	0	0	0	0	0.3	0
4312_OG5_165265_7 - FUNGI_YDR103W	YDR103W	"STE5 - Pheromone-response scaffold protein that controls the mating decision; binds Ste11p, Ste7p, and Fus3p kinases, forming a MAPK cascade complex that interacts with the plasma membrane and Ste4p-Ste18p; allosteric activator of Fus3p"	1	0	0	0	0	0	0.3	0
4313_OG5_165266_7 - FUNGI_YJL127C-B	YJL127C-B	"YJL127C-B - Putative protein of unknown function; identified based on homology to the filamentous fungus, <i>Ashbya gossypii</i>"	1	0	0	0	0	0	0.3	0
4314_OG5_165270_7 - FUNGI_YNL162W-A	YNL162W-A	YNL162W-A - Putative protein of unknown function; identified by homology	1	0	0	0	0	0	0.3	0
4315_OG5_165425_7 - FUNGI_YDL231C	YDL231C	"BRE4 - Zinc finger protein containing five transmembrane domains; null mutant exhibits strongly fragmented vacuoles and sensitivity to brefeldin A, a drug which is known to affect intracellular transport"	1	0	0	0	0	0	0.3	0
4316_OG5_165428_7 - FUNGI_YPR122W	YPR122W	AXL1 - Haploid specific endoprotease that performs one of two N-terminal cleavages during maturation of a-factor mating pheromone; required for axial budding pattern of haploid cells	1	0	0	0	0	0	0.3	0
4317_OG5_165429_7 - FUNGI_YHL026C	YHL026C	YHL026C - Putative protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; YHL026C is not an essential gene; in 2005 the start site was moved 141 nt upstream (see Locus History)	1	0	0	0	0	0	0.3	0
4318_OG5_165430_7 - FUNGI_YLR364W	YLR364W	GRX8 - Glutaredoxin that employs a dithiol mechanism of catalysis; monomeric; activity is low and null mutation does not affect sensitivity to oxidative stress; GFP-fusion protein localizes to the cytoplasm; expression strongly induced by arsenic	1	0	0	0	0	0	0.3	0
4319_OG5_165433_7 - FUNGI_YGL250W	YGL250W	RMR1 - Protein required for meiotic recombination and gene conversion; null mutant displays reduced PIS1 expression and growth defects on non-fermentable carbon sources and minimal media; GFP-fusion protein localizes to both cytoplasm and nucleus	1	0	0	0	0	0	0.3	0
4320_OG5_165437_7 - FUNGI_YDL177C	YDL177C	YDL177C - Putative protein of unknown function; similar to the mouse IMPACT gene; YDL177C is not an essential gene	1	0	0	0	0	0	0.3	0
4321_OG5_165910_7 - FUNGI_YGL041W-A	YGL041W-A	"YGL041W-A - Putative protein of unknown function, conserved in fungi; identified by expression profiling and mass spectrometry"	1	0	0	0	0	0	0.3	0
4322_OG5_146700_7 - FUNGI_YOR195W	YOR195W	"SLK19 - Kinetochore-associated protein required for normal segregation of chromosomes in meiosis and mitosis; component of the FEAR regulatory network, which promotes Cdc14p release from the nucleolus during anaphase; potential Cdc28p substrate"	1	0.0625	0	0	0.047619048	0	0.3	0.0625
4323_OG5_150679_7 - FUNGI_YCR020C	YCR020C	"PET18 - Protein of unknown function, has weak similarity to proteins involved in thiamin metabolism; expression is induced in the absence of thiamin"	1	0	0.027777778	0.125	0.047619048	0	0.3	0
4324_OG5_145195_7 - FUNGI_YNL190W	YNL190W	YNL190W - Cell wall protein of unknown function; proposed role as a hydrophilin induced by osmotic stress; contains a putative GPI-attachment site	1	0	0	0	0.047619048	0.071428571	0.3	0
4325_OG5_150100_7 - FUNGI_YKL084W	YKL084W	"HOT13 - Zinc-binding mitochondrial intermembrane space (IMS) protein involved in a disulfide relay system for IMS import of cysteine-containing proteins; binds Mia40p and stimulates its Erv1p-dependent oxidation, probably by sequestering zinc"	1	0.0625	0.055555556	0	0	0	0.3	0
4326_OG5_147034_7 - FUNGI_YML051W	YML051W	GAL80 - Transcriptional regulator involved in the repression of GAL genes in the absence of galactose; inhibits transcriptional activation by Gal4p; inhibition relieved by Gal3p or Gal1p binding	1	0	0.027777778	0.125	0	0	0.3	0
4327_OG5_153044_7 - FUNGI_Q0115	Q0115	"BI3 - Mitochondrial mRNA maturase, forms a complex with Mrs1p to mediate splicing of the bI3 intron of the COB gene; encoded by both exon and intron sequences of partially processed COB mRNA"	1	0	0	0	0.095238095	0	0.25	0
4328_OG5_159073_7 - FUNGI_YJL076W	YJL076W	"NET1 - Core subunit of the RENT complex, which is a complex involved in nucleolar silencing and telophase exit; stimulates transcription by RNA polymerase I and regulates nucleolar structure"	1	0	0	0	0.047619048	0	0.25	0.0625
4329_OG5_159884_7 - FUNGI_YPL202C	YPL202C	AFT2 - Iron-regulated transcriptional activator; activates genes involved in intracellular iron use and required for iron homeostasis and resistance to oxidative stress; similar to Aft1p	1	0	0	0	0.047619048	0	0.25	0
4330_OG5_160769_7 - FUNGI_YER176W	YER176W	"ECM32 - DNA dependent ATPase/DNA helicase belonging to the Dna2p- and Nam7p-like family of helicases that is involved in modulating translation termination; interacts with the translation termination factors, localized to polysomes"	1	0	0	0	0.047619048	0	0.25	0
4331_OG5_162838_7 - FUNGI_YBL046W	YBL046W	"PSY4 - Regulatory subunit of protein phosphatase PP4; presence of Psy4p in the PP4 complex (along with catalytic subunit Pph3p and Psy2p) is required for dephosphorylation of the histone variant H2AX, but not for dephosphorylation of Rad53p, during recovery from the DNA damage checkpoint; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; required for cisplatin resistance; homolog of mammalian R2"	1	0	0	0	0.047619048	0	0.25	0
4332_OG5_139630_7 - FUNGI_YKL096W	YKL096W	"CWP1 - Cell wall mannoprotein that localizes specifically to birth scars of daughter cells, linked to a beta-1,3- and beta-1,6-glucan heteropolymer through a phosphodiester bond; required for propionic acid resistance"	1	0	0	0	0	0	0.25	0
4333_OG5_149922_7 - FUNGI_YER001W	YER001W	"MNN1 - Alpha-1,3-mannosyltransferase, integral membrane glycoprotein of the Golgi complex, required for addition of alpha1,3-mannose linkages to N-linked and O-linked oligosaccharides, one of five S. cerevisiae proteins of the MNN1 family"	1	0	0	0	0	0	0.25	0
4334_OG5_159600_7 - FUNGI_YGL257C	YGL257C	MNT2 - Mannosyltransferase involved in adding the 4th and 5th mannose residues of O-linked glycans	1	0	0	0	0	0	0.25	0
4335_OG5_159600_7 - FUNGI_YNR059W	YNR059W	"MNT4 - Putative alpha-1,3-mannosyltransferase, not required for protein O-glycosylation"	1	0	0	0	0	0	0.25	0
4336_OG5_160787_7 - FUNGI_YCR040W	YCR040W	MATALPHA1 - Transcriptional co-activator involved in regulation of mating-type-specific gene expression; targets the transcription factor Mcm1p to the promoters of alpha-specific genes; one of two genes encoded by the MATalpha mating type cassette	1	0	0	0	0	0	0.25	0
4337_OG5_160787_7 - FUNGI_YCL066W	YCL066W	"HMLALPHA1 - Silenced copy of ALPHA1 at HML, encoding a transcriptional coactivator involved in the regulation of mating-type alpha-specific gene expression"	1	0	0	0	0	0	0.25	0
4338_OG5_162592_7 - FUNGI_YER101C	YER101C	"AST2 - Protein that may have a role in targeting of plasma membrane [H+]ATPase (Pma1p) to the plasma membrane, as suggested by analysis of genetic interactions"	1	0	0	0	0	0	0.25	0
4339_OG5_162592_7 - FUNGI_YBL069W	YBL069W	"AST1 - Peripheral membrane protein that interacts with the plasma membrane ATPase Pma1p and has a role in its targeting to the plasma membrane, possibly by influencing its incorporation into lipid rafts"	1	0	0	0	0	0	0.25	0
4340_OG5_162845_7 - FUNGI_YCL039W	YCL039W	"GID7 - Protein of unknown function, involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; contains six WD40 repeats; computational analysis suggests that Gid7p and Moh1p have similar functions"	1	0	0	0	0	0	0.25	0
4341_OG5_163159_7 - FUNGI_YLR394W	YLR394W	CST9 - SUMO E3 ligase; required for synaptonemal complex formation; localizes to synapsis initiation sites on meiotic chromosomes; potential Cdc28p substrate	1	0	0	0	0	0	0.25	0
4342_OG5_163448_7 - FUNGI_YDR314C	YDR314C	RAD34 - Protein involved in nucleotide excision repair (NER); homologous to RAD4	1	0	0	0	0	0	0.25	0
4343_OG5_163504_7 - FUNGI_YJL073W	YJL073W	"JEM1 - DnaJ-like chaperone required for nuclear membrane fusion during mating, localizes to the ER membrane; exhibits genetic interactions with KAR2"	1	0	0	0	0	0	0.25	0
4344_OG5_163584_7 - FUNGI_YDR235W	YDR235W	"PRP42 - U1 snRNP protein involved in splicing, required for U1 snRNP biogenesis; contains multiple tetriatricopeptide repeats"	1	0	0	0	0	0	0.25	0
4345_OG5_163585_7 - FUNGI_YER130C	YER130C	"YER130C - Protein of unknown function; transcription is regulated by Haa1p, Sok2p and Zap1p transcriptional activators; the C. Albicans homolog (MNL1) plays a role in adaptation to stress"	1	0	0	0	0	0	0.25	0
4346_OG5_163605_7 - FUNGI_YJR056C	YJR056C	YJR056C - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus	1	0	0	0	0	0	0.25	0
4347_OG5_163669_7 - FUNGI_YHR071W	YHR071W	"PCL5 - Cyclin, interacts with and phosphorylated by Pho85p cyclin-dependent kinase (Cdk), induced by Gcn4p at level of transcription, specifically required for Gcn4p degradation, may be sensor of cellular protein biosynthetic capacity"	1	0	0	0	0	0	0.25	0
4348_OG5_163949_7 - FUNGI_YOR344C	YOR344C	TYE7 - Serine-rich protein that contains a basic-helix-loop-helix (bHLH) DNA binding motif; binds E-boxes of glycolytic genes and contributes to their activation; may function as a transcriptional activator in Ty1-mediated gene expression	1	0	0	0	0	0	0.25	0
4349_OG5_164003_7 - FUNGI_YHR152W	YHR152W	"SPO12 - Nucleolar protein of unknown function, positive regulator of mitotic exit; involved in regulating release of Cdc14p from the nucleolus in early anaphase, may play similar role in meiosis"	1	0	0	0	0	0	0.25	0
4350_OG5_164003_7 - FUNGI_YGR230W	YGR230W	"BNS1 - Protein with some similarity to Spo12p; overexpression bypasses need for Spo12p, but not required for meiosis"	1	0	0	0	0	0	0.25	0
4351_OG5_164252_7 - FUNGI_YOR208W	YOR208W	PTP2 - Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; localized to the nucleus	1	0	0	0	0	0	0.25	0
4352_OG5_165222_7 - FUNGI_YNL249C	YNL249C	"MPA43 - Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"	1	0	0	0	0	0	0.25	0
4353_OG5_165236_7 - FUNGI_YJL171C	YJL171C	"YJL171C - GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein"	1	0	0	0	0	0	0.25	0
4354_OG5_165240_7 - FUNGI_YGL222C	YGL222C	"EDC1 - RNA-binding protein, activates mRNA decapping directly by binding to the mRNA substrate and enhancing the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress"	1	0	0	0	0	0	0.25	0
4355_OG5_165246_7 - FUNGI_YJL205C	YJL205C	"NCE101 - Protein of unknown function, involved in secretion of proteins that lack classical secretory signal sequences"	1	0	0	0	0	0	0.25	0
4356_OG5_168924_7 - FUNGI_YLR440C	YLR440C	SEC39 - Component of the Dsl1p tethering complex that interacts with ER SNAREs Sec20p and Use1p; proposed to be involved in protein secretion; localizes to the ER and nuclear envelope	1	0	0	0	0	0	0.25	0
4357_OG5_168970_7 - FUNGI_YLR214W	YLR214W	"FRE1 - Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low copper and iron levels"	1	0	0	0	0	0	0.25	0
4358_OG5_169043_7 - FUNGI_YJL105W	YJL105W	"SET4 - Protein of unknown function, contains a SET domain"	1	0	0	0	0	0	0.25	0
4359_OG5_169073_7 - FUNGI_YJR136C	YJR136C	TTI2 - Putative protein of unknown function; subunit of the ASTRA complex which is part of the chromatin remodeling machinery; similar to S. pombe Tti2p; may interact with Rsm23p; GFP-fusion protein localizes to the cytoplasm	1	0	0	0	0	0	0.25	0
4360_OG5_169288_7 - FUNGI_YOL087C	YOL087C	"YOL087C - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; deletion mutant is sensitive to various chemicals including phenanthroline, sanguinarine, and nordihydroguaiaretic acid"	1	0	0	0	0	0	0.25	0
4361_OG5_169673_7 - FUNGI_YPL208W	YPL208W	"RKM1 - SET-domain lysine-N-methyltransferase, catalyzes the formation of dimethyllysine residues on the large ribsomal subunit protein L23a (RPL23A and RPL23B)"	1	0	0	0	0	0	0.25	0
4362_OG5_171019_7 - FUNGI_YNL322C	YNL322C	KRE1 - Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor	1	0	0	0	0	0	0.25	0
4363_OG5_171612_7 - FUNGI_YDR277C	YDR277C	"MTH1 - Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation"	1	0	0	0	0	0	0.25	0
4364_OG5_171625_7 - FUNGI_YML066C	YML066C	SMA2 - Meiosis-specific prospore membrane protein; required to produce bending force necessary for proper assembly of the prospore membrane during sporulation	1	0	0	0	0	0	0.25	0
4365_OG5_171666_7 - FUNGI_YOR137C	YOR137C	SIA1 - Protein of unassigned function involved in activation of the Pma1p plasma membrane H+-ATPase by glucose	1	0	0	0	0	0	0.25	0
4366_OG5_171667_7 - FUNGI_YMR232W	YMR232W	FUS2 - Cytoplasmic protein localized to the shmoo tip; required for the alignment of parental nuclei before nuclear fusion during mating	1	0	0	0	0	0	0.25	0
4367_OG5_171670_7 - FUNGI_YDR089W	YDR089W	YDR089W - Protein of unknown function; deletion confers resistance to Nickel	1	0	0	0	0	0	0.25	0
4368_OG5_171671_7 - FUNGI_YOR020W-A	YOR020W-A	"YOR020W-A - Putative protein of unknown function, conserved in A. gossypii; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"	1	0	0	0	0	0	0.25	0
4369_OG5_171922_7 - FUNGI_YHL025W	YHL025W	SNF6 - Subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf5p	1	0	0	0	0	0	0.25	0
4370_OG5_171926_7 - FUNGI_YDR197W	YDR197W	"CBS2 - Mitochondrial translational activator of the COB mRNA; interacts with translating ribosomes, acts on the COB mRNA 5'-untranslated leader"	1	0	0	0	0	0	0.25	0
4371_OG5_171928_7 - FUNGI_YGR016W	YGR016W	YGR016W - Putative protein of unknown function	1	0	0	0	0	0	0.25	0
4372_OG5_171940_7 - FUNGI_YLR211C	YLR211C	YLR211C - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR211C is not an essential gene; ORF contains an intron	1	0	0	0	0	0	0.25	0
4373_OG5_171944_7 - FUNGI_YDR446W	YDR446W	"ECM11 - Non-essential protein apparently involved in meiosis, GFP fusion protein is present in discrete clusters in the nucleus throughout mitosis; may be involved in maintaining chromatin structure"	1	0	0	0	0	0	0.25	0
4374_OG5_171946_7 - FUNGI_YKR006C	YKR006C	"MRPL13 - Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation"	1	0	0	0	0	0	0.25	0
4375_OG5_171948_7 - FUNGI_YPL007C	YPL007C	TFC8 - One of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; linker between TauB and TauA domains; human homolog is TFIIIC-90	1	0	0	0	0	0	0.25	0
4376_OG5_171951_7 - FUNGI_YLR445W	YLR445W	YLR445W - Putative protein of unknown function; transcription is regulated by Ume6p and induced in response to alpha factor	1	0	0	0	0	0	0.25	0
4377_OG5_134737_7 - FUNGI_YLL060C	YLL060C	"GTT2 - Glutathione S-transferase capable of homodimerization; functional overlap with Gtt2p, Grx1p, and Grx2p"	1	0	0.305555556	0.125	0.142857143	0	0.25	0
4378_OG5_150109_7 - FUNGI_Q0110	Q0110	"BI2 - Mitochondrial mRNA maturase with a role in splicing, encoded by both exon and intron sequences of partially processed COB mRNA"	1	0.0625	0	0	0.047619048	0	0.25	0.0625
4379_OG5_133776_7 - FUNGI_YNR073C	YNR073C	YNR073C - Putative mannitol dehydrogenase	1	0	0.305555556	0.125	0.047619048	0	0.25	0
4380_OG5_133776_7 - FUNGI_YEL070W	YEL070W	DSF1 - Deletion suppressor of mpt5 mutation	1	0	0.305555556	0.125	0.047619048	0	0.25	0
4381_OG5_140225_7 - FUNGI_YCR023C	YCR023C	YCR023C - Vacuolar membrane protein of unknown function; member of the multidrug resistance family; YCR023C is not an essential gene	1	0	0	0.125	0.047619048	0	0.25	0.125
4382_OG5_142688_7 - FUNGI_YEL066W	YEL066W	"HPA3 - D-Amino acid N-acetyltransferase, catalyzes N-acetylation of D-amino acids through ordered bi-bi mechanism in which acetyl-CoA is first substrate bound and CoA is last product liberated; similar to Hpa2p, acetylates histones weakly in vitro"	1	0	0.138888889	0.125	0	0	0.25	0
4383_OG5_142688_7 - FUNGI_YPR193C	YPR193C	"HPA2 - Tetrameric histone acetyltransferase with similarity to Gcn5p, Hat1p, Elp3p, and Hpa3p; acetylates histones H3 and H4 in vitro and exhibits autoacetylation activity"	1	0	0.138888889	0.125	0	0	0.25	0
4384_OG5_162929_7 - FUNGI_YLR424W	YLR424W	"SPP382 - Essential protein that forms a dimer with Ntr2p; also forms a trimer, with Ntr2p and Prp43p, that is involved in spliceosome disassembly; found also in a multisubunit complex with the splicing factor Clf1p; suppressor of prp38-1 mutation"	1	0	0	0.125	0	0	0.25	0
4385_OG5_163678_7 - FUNGI_YIL015W	YIL015W	"BAR1 - Aspartyl protease secreted into the periplasmic space of mating type a cells, helps cells find mating partners, cleaves and inactivates alpha factor allowing cells to recover from alpha-factor-induced cell cycle arrest"	1	0	0	0.125	0	0	0.25	0
4386_OG5_158391_7 - FUNGI_YBR083W	YBR083W	"TEC1 - Transcription factor required for full Ty1 expression, Ty1-mediated gene activation, and haploid invasive and diploid pseudohyphal growth; TEA/ATTS DNA-binding domain family member"	1	0	0	0.125	0.047619048	0.071428571	0.2	0
4387_OG5_132710_7 - FUNGI_YNL093W	YNL093W	"YPT53 - Rab family GTPase, similar to Ypt51p and Ypt52p and to mammalian rab5; required for vacuolar protein sorting and endocytosis"	1	0	0	0	0.523809524	0	0.2	0.25
4388_OG5_156232_7 - FUNGI_YDR503C	YDR503C	"LPP1 - Lipid phosphate phosphatase, catalyzes Mg(2+)-independent dephosphorylation of phosphatidic acid (PA), lysophosphatidic acid, and diacylglycerol pyrophosphate; involved in control of the cellular levels of phosphatidylinositol and PA"	1	0	0	0	0.142857143	0	0.2	0.0625
4389_OG5_153119_7 - FUNGI_YGR250C	YGR250C	YGR250C - Putative RNA binding protein; localizes to stress granules induced by glucose deprivation; interacts with Rbg1p in a two-hybrid	1	0	0	0	0.095238095	0	0.2	0.125
4390_OG5_163974_7 - FUNGI_YDR034W-B	YDR034W-B	YDR034W-B - Predicted tail-anchored plasma membrane protein containing a conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery	1	0	0	0	0.095238095	0	0.2	0
4391_OG5_146448_7 - FUNGI_YGL096W	YGL096W	TOS8 - Homeodomain-containing protein and putative transcription factor found associated with chromatin; target of SBF transcription factor; induced during meiosis and under cell-damaging conditions; similar to Cup9p transcription factor	1	0	0	0	0	0.071428571	0.2	0.125
4392_OG5_170252_7 - FUNGI_YOL020W	YOL020W	"TAT2 - High affinity tryptophan and tyrosine permease, overexpression confers FK506 and FTY720 resistance"	1	0	0	0	0	0.071428571	0.2	0
4393_OG5_168916_7 - FUNGI_YLR067C	YLR067C	"PET309 - Specific translational activator for the COX1 mRNA, also influences stability of intron-containing COX1 primary transcripts; localizes to the mitochondrial inner membrane; contains seven pentatricopeptide repeats (PPRs)"	1	0	0	0	0.047619048	0	0.2	0
4394_OG5_171766_7 - FUNGI_YMR255W	YMR255W	"GFD1 - Coiled-coiled protein of unknown function, identified as a high-copy suppressor of a dbp5 mutation"	1	0	0	0	0.047619048	0	0.2	0
4395_OG5_171920_7 - FUNGI_YER032W	YER032W	"FIR1 - Protein involved in 3' mRNA processing, interacts with Ref2p; potential Cdc28p substrate"	1	0	0	0	0.047619048	0	0.2	0
4396_OG5_171929_7 - FUNGI_YIL101C	YIL101C	"XBP1 - Transcriptional repressor that binds to promoter sequences of the cyclin genes, CYS3, and SMF2; expression is induced by stress or starvation during mitosis, and late in meiosis; member of the Swi4p/Mbp1p family; potential Cdc28p substrate"	1	0	0	0	0.047619048	0	0.2	0
4397_OG5_171931_7 - FUNGI_YNL176C	YNL176C	"TDA7 - Cell cycle-regulated gene of unknown function, promoter bound by Fkh2p; null mutant is sensitive to expression of the top1-T722A allele"	1	0	0	0	0.047619048	0	0.2	0
4398_OG5_171952_7 - FUNGI_YLR141W	YLR141W	"RRN5 - Protein involved in transcription of rDNA by RNA polymerase I; transcription factor, member of UAF (upstream activation factor) family along with Rrn9p and Rrn10p"	1	0	0	0	0.047619048	0	0.2	0
4399_OG5_170036_7 - FUNGI_YDR195W	YDR195W	"REF2 - RNA-binding protein involved in the cleavage step of mRNA 3'-end formation prior to polyadenylation, and in snoRNA maturation; part of holo-CPF subcomplex APT, which associates with 3'-ends of snoRNA- and mRNA-encoding genes"	1	0	0.027777778	0	0	0	0.2	0
4400_OG5_157032_7 - FUNGI_YCR039C	YCR039C	"MATALPHA2 - Homeobox-domain protein that, with Mcm1p, represses a-specific genes in haploids; acts with A1p to repress transcription of haploid-specific genes in diploids; one of two genes encoded by the MATalpha mating type cassette"	1	0	0	0	0	0	0.2	0
4401_OG5_157032_7 - FUNGI_YCL067C	YCL067C	HMLALPHA2 - Silenced copy of ALPHA2 at HML; homeobox-domain protein that associates with Mcm1p in haploid cells to repress a-specific gene expression and interacts with a1p in diploid cells to repress haploid-specific gene expression	1	0	0	0	0	0	0.2	0
4402_OG5_157032_7 - FUNGI_YCR096C	YCR096C	HMRA2 - Silenced copy of a2 at HMR; similarity to Alpha2p; required along with a1p for inhibiting expression of the HO endonuclease in a/alpha HO/HO diploid cells with an active mating-type interconversion system	1	0	0	0	0	0	0.2	0
4403_OG5_159087_7 - FUNGI_YLR332W	YLR332W	"MID2 - O-glycosylated plasma membrane protein that acts as a sensor for cell wall integrity signaling and activates the pathway; interacts with Rom2p, a guanine nucleotide exchange factor for Rho1p, and with cell integrity pathway protein Zeo1p"	1	0	0	0	0	0	0.2	0.125
4404_OG5_160922_7 - FUNGI_YPL139C	YPL139C	"UME1 - Negative regulator of meiosis, required for repression of a subset of meiotic genes during vegetative growth, binding of histone deacetylase Rpd3p required for activity, contains a NEE box and a WD repeat motif; homologous with Wtm1p, Wtm2p"	1	0	0	0	0	0	0.2	0
4405_OG5_160922_7 - FUNGI_YOR229W	YOR229W	"WTM2 - Transcriptional modulator involved in regulation of meiosis, silencing, and expression of RNR genes; involved in response to replication stress; contains WD repeats"	1	0	0	0	0	0	0.2	0
4406_OG5_160922_7 - FUNGI_YOR230W	YOR230W	"WTM1 - Transcriptional modulator involved in regulation of meiosis, silencing, and expression of RNR genes; required for nuclear localization of the ribonucleotide reductase small subunit Rnr2p and Rnr4p; contains WD repeats"	1	0	0	0	0	0	0.2	0
4407_OG5_163085_7 - FUNGI_YOR148C	YOR148C	"SPP2 - Essential protein that promotes the first step of splicing and is required for the final stages of spliceosome maturation; interacts with Prp2p, which may release Spp2p from the spliceosome following the first cleavage reaction"	1	0	0	0	0	0	0.2	0
4408_OG5_163517_7 - FUNGI_YPL166W	YPL166W	ATG29 - Autophagy-specific protein that is required for recruitment of other ATG proteins to the pre-autophagosomal structure (PAS); interacts with Atg17p and localizas to the PAS in a manner interdependent with Atg17p and Cis1p; not conserved	1	0	0	0	0	0	0.2	0.0625
4409_OG5_164057_7 - FUNGI_YBR152W	YBR152W	"SPP381 - mRNA splicing factor, component of U4/U6.U5 tri-snRNP; interacts genetically and physically with Prp38p"	1	0	0	0	0	0	0.2	0.0625
4410_OG5_165235_7 - FUNGI_YML058W	YML058W	SML1 - Ribonucleotide reductase inhibitor involved in regulating dNTP production; regulated by Mec1p and Rad53p during DNA damage and S phase	1	0	0	0	0	0	0.2	0
4411_OG5_165235_7 - FUNGI_YLR437C	YLR437C	DIF1 - Protein that regulates the nuclear localization of ribonucleotide reductase Rnr2p and Rnr4p subunits; phosphorylated by Dun1p in response to DNA damage and degraded; N-terminal half has similarity to S. pombe Spd1 protein	1	0	0	0	0	0	0.2	0
4412_OG5_165423_7 - FUNGI_YCL049C	YCL049C	YCL049C - Protein of unknown function; localizes to membrane fraction; YCL049C is not an essential gene	1	0	0	0	0	0	0.2	0
4413_OG5_165424_7 - FUNGI_YGR041W	YGR041W	"BUD9 - Protein involved in bud-site selection; mutant has increased aneuploidy tolerance; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the distal pole"	1	0	0	0	0	0	0.2	0
4414_OG5_165424_7 - FUNGI_YLR353W	YLR353W	"BUD8 - Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the proximal pole"	1	0	0	0	0	0	0.2	0
4415_OG5_165426_7 - FUNGI_YDL239C	YDL239C	"ADY3 - Protein required for spore wall formation, thought to mediate assembly of a Don1p-containing structure at the leading edge of the prospore membrane via interaction with spindle pole body components; potentially phosphorylated by Cdc28p"	1	0	0	0	0	0	0.2	0
4416_OG5_165426_7 - FUNGI_YNL225C	YNL225C	CNM67 - Component of the spindle pole body outer plaque; required for spindle orientation and mitotic nuclear migration	1	0	0	0	0	0	0.2	0
4417_OG5_168431_7 - FUNGI_YDR464W	YDR464W	SPP41 - Protein involved in negative regulation of expression of spliceosome components PRP4 and PRP3	1	0	0	0	0	0	0.2	0.0625
4418_OG5_169262_7 - FUNGI_YHR079C-A	YHR079C-A	"SAE3 - Meiosis specific protein involved in DMC1-dependent meiotic recombination, forms heterodimer with Mei5p; proposed to be an assembly factor for Dmc1p"	1	0	0	0	0	0	0.2	0
4419_OG5_169538_7 - FUNGI_YJL137C	YJL137C	"GLG2 - Self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin"	1	0	0	0	0	0	0.2	0
4420_OG5_169669_7 - FUNGI_YMR032W	YMR032W	"HOF1 - Bud neck-localized, SH3 domain-containing protein required for cytokinesis; regulates actomyosin ring dynamics and septin localization; interacts with the formins, Bni1p and Bnr1p, and with Cyk3p, Vrp1p, and Bni5p"	1	0	0	0	0	0	0.2	0.0625
4421_OG5_169736_7 - FUNGI_YDR319C	YDR319C	"YDR319C - Putative protein of unknown function, identified as an ortholog of the highly conserved FIT family of proteins involved in triglyceride droplet biosynthesis; interacts with Sst2p and Hsp82p in high-throughput two-hybrid screens"	1	0	0	0	0	0	0.2	0
4422_OG5_169758_7 - FUNGI_YGR044C	YGR044C	RME1 - Zinc finger protein involved in control of meiosis; prevents meiosis by repressing IME1 expression and promotes mitosis by activating CLN2 expression; directly repressed by a1-alpha2 regulator; mediates cell type control of sporulation	1	0	0	0	0	0	0.2	0
4423_OG5_169957_7 - FUNGI_YGL021W	YGL021W	ALK1 - Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; similar to Alk2p and to mammalian haspins	1	0	0	0	0	0	0.2	0.0625
4424_OG5_171579_7 - FUNGI_YIL073C	YIL073C	"SPO22 - Meiosis-specific protein essential for chromosome synapsis, involved in completion of nuclear divisions during meiosis; induced early in meiosis"	1	0	0	0	0	0	0.2	0
4425_OG5_171582_7 - FUNGI_YEL072W	YEL072W	RMD6 - Protein required for sporulation	1	0	0	0	0	0	0.2	0
4426_OG5_171603_7 - FUNGI_YOR045W	YOR045W	TOM6 - Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex	1	0	0	0	0	0	0.2	0
4427_OG5_171609_7 - FUNGI_YLR256W	YLR256W	HAP1 - Zinc finger transcription factor involved in the complex regulation of gene expression in response to levels of heme and oxygen; the S288C sequence differs from other strain backgrounds due to a Ty1 insertion in the carboxy terminus	1	0	0	0	0	0	0.2	0
4428_OG5_171611_7 - FUNGI_YOR047C	YOR047C	"STD1 - Protein involved in control of glucose-regulated gene expression; interacts with kinase Snf1p, glucose sensors Snf3p and Rgt2p, TATA-binding Spt15p; regulator of transcription factor Rgt1p; interactions with Pma1p appear to propagate [GAR+]"	1	0	0	0	0	0	0.2	0
4429_OG5_171621_7 - FUNGI_YOR371C	YOR371C	"GPB1 - Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; promotes ubiquitin-dependent proteolysis of Ira2p; regulated by G-alpha protein Gpa2p; homolog of Gpb2p"	1	0	0	0	0	0	0.2	0
4430_OG5_171645_7 - FUNGI_YLR224W	YLR224W	YLR224W - F-box protein and component of SCF ubiquitin ligase complexes involved in ubiquitin-dependent protein catabolism; readily monoubiquitinated in vitro by SCF-Ubc4 complexes; YLR224W is not an essential gene	1	0	0	0	0	0	0.2	0
4431_OG5_171652_7 - FUNGI_YIL117C	YIL117C	"PRM5 - Pheromone-regulated protein, predicted to have 1 transmembrane segment; induced during cell integrity signaling"	1	0	0	0	0	0	0.2	0
4432_OG5_171654_7 - FUNGI_YOR315W	YOR315W	"SFG1 - Nuclear protein, putative transcription factor required for growth of superficial pseudohyphae (which do not invade the agar substrate) but not for invasive pseudohyphal growth; may act together with Phd1p; potential Cdc28p substrate"	1	0	0	0	0	0	0.2	0
4433_OG5_171658_7 - FUNGI_YAL051W	YAL051W	"OAF1 - Oleate-activated transcription factor, acts alone and as a heterodimer with Pip2p; activates genes involved in beta-oxidation of fatty acids and peroxisome organization and biogenesis"	1	0	0	0	0	0	0.2	0
4434_OG5_171658_7 - FUNGI_YOR363C	YOR363C	"PIP2 - Autoregulatory oleate-specific transcriptional activator of peroxisome proliferation, contains Zn(2)-Cys(6) cluster domain, forms heterodimer with Oaf1p, binds oleate response elements (OREs), activates beta-oxidation genes"	1	0	0	0	0	0	0.2	0
4435_OG5_171661_7 - FUNGI_YOL017W	YOL017W	"ESC8 - Protein involved in telomeric and mating-type locus silencing, interacts with Sir2p and also interacts with the Gal11p, which is a component of the RNA pol II mediator complex"	1	0	0	0	0	0	0.2	0
4436_OG5_171914_7 - FUNGI_YLR298C	YLR298C	"YHC1 - Component of the U1 snRNP complex required for pre-mRNA splicing; putative ortholog of human U1C protein, which is involved in formation of a complex between U1 snRNP and the pre-mRNA 5' splice site"	1	0	0	0	0	0	0.2	0
4437_OG5_171919_7 - FUNGI_YPR109W	YPR109W	YPR109W - Predicted membrane protein; dipoid deletion strain has high budding index	1	0	0	0	0	0	0.2	0
4438_OG5_171923_7 - FUNGI_YMR181C	YMR181C	YMR181C - Protein of unknown function; mRNA transcribed as part of a bicistronic transcript with a predicted transcriptional repressor RGM1/YMR182C; mRNA is destroyed by nonsense-mediated decay (NMD); YMR181C is not an essential gene	1	0	0	0	0	0	0.2	0
4439_OG5_171923_7 - FUNGI_YPL229W	YPL229W	YPL229W - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL229W is not an essential gene	1	0	0	0	0	0	0.2	0
4440_OG5_171924_7 - FUNGI_YHR022C	YHR022C	YHR022C - Putative protein of unknown function; YHR022C is not an essential gene	1	0	0	0	0	0	0.2	0
4441_OG5_171930_7 - FUNGI_YPR115W	YPR115W	RGC1 - Pleckstrin homology domain containing protein proposed to function as a glycerol channel activator; paralogous to Ask10p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	1	0	0	0	0	0	0.2	0
4442_OG5_171930_7 - FUNGI_YGR097W	YGR097W	"ASK10 - Component of RNA polymerase II holoenzyme, phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p; proposed to function in activation of the glycerol channel Fps1p; paralogous to Rgc1p"	1	0	0	0	0	0	0.2	0
4443_OG5_171936_7 - FUNGI_YER158C	YER158C	"YER158C - Protein of unknown function, has similarity to Afr1p; potentially phosphorylated by Cdc28p"	1	0	0	0	0	0	0.2	0
4444_OG5_171936_7 - FUNGI_YDR085C	YDR085C	AFR1 - Protein required for pheromone-induced projection (shmoo) formation; regulates septin architecture during mating; has an RVXF motif that mediates targeting of Glc7p to mating projections; interacts with Cdc12p	1	0	0	0	0	0	0.2	0
4445_OG5_171937_7 - FUNGI_YBR270C	YBR270C	"BIT2 - Subunit of TORC2, a membrane-associated complex that regulates actin cytoskeletal dynamics during polarized growth and cell wall integrity; interacts with Slm1p and Slm2p, homologous PH domain-containing TORC2 substrates; similar to Bit61p"	1	0	0	0	0	0	0.2	0
4446_OG5_171937_7 - FUNGI_YJL058C	YJL058C	"BIT61 - Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p-Slm1p-Slm2p), a membrane-associated complex that regulates cell cycle-dependent actin cytoskeletal dynamics during polarized growth and cell wall integrity"	1	0	0	0	0	0	0.2	0
4447_OG5_171943_7 - FUNGI_YDL021W	YDL021W	"GPM2 - Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event"	1	0	0	0	0	0	0.2	0
4448_OG5_171943_7 - FUNGI_YOL056W	YOL056W	"GPM3 - Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event"	1	0	0	0	0	0	0.2	0
4449_OG5_171949_7 - FUNGI_YIR010W	YIR010W	DSN1 - Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; important for chromosome segregation	1	0	0	0	0	0	0.2	0.0625
4450_OG5_171950_7 - FUNGI_YOR062C	YOR062C	YOR062C - Protein of unknown function; similar to YKR075Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS	1	0	0	0	0	0	0.2	0
4451_OG5_171950_7 - FUNGI_YKR075C	YKR075C	YKR075C - Protein of unknown function; similar to YOR062Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS	1	0	0	0	0	0	0.2	0
4452_OG5_174988_7 - FUNGI_YLR073C	YLR073C	RFU1 - Protein that inhibits Doa4p deubiquitinating activity; contributes to ubiquitin homeostasis by regulating the conversion of free ubiquitin chains to ubiquitin monomers by Doa4p; GFP-fusion protein localizes to endosomes	1	0	0	0	0	0	0.2	0
4453_OG5_175192_7 - FUNGI_YGR191W	YGR191W	"HIP1 - High-affinity histidine permease, also involved in the transport of manganese ions"	1	0	0	0	0	0	0.2	0
4454_OG5_175420_7 - FUNGI_YHR078W	YHR078W	YHR078W - High osmolarity-regulated gene of unknown function	1	0	0	0	0	0	0.2	0
4455_OG5_175473_7 - FUNGI_YPL100W	YPL100W	"ATG21 - Phosphoinositide binding protein required for vesicle formation in the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein"	1	0	0	0	0	0	0.2	0
4456_OG5_175577_7 - FUNGI_YMR087W	YMR087W	YMR087W - Putative ADP-ribose-1''-monophosphatase that converts ADP-ribose-1''-monophosphate to ADP-ribose; may have a role in tRNA splicing; contains an A1pp domain	1	0	0	0	0	0	0.2	0
4457_OG5_175698_7 - FUNGI_YDR532C	YDR532C	"KRE28 - Subunit of a kinetochore-microtubule binding complex with Spc105p that bridges centromeric heterochromatin and kinetochore MAPs and motors, and is also required for sister chromatid bi-orientation and kinetochore binding of SAC components"	1	0	0	0	0	0	0.2	0
4458_OG5_175783_7 - FUNGI_YPR188C	YPR188C	"MLC2 - Regulatory light chain for the type II myosin, Myo1p; binds to an IQ motif of Myo1p, localization to the bud neck depends on Myo1p; involved in the disassembly of the Myo1p ring"	1	0	0	0	0	0	0.2	0
4459_OG5_175799_7 - FUNGI_YGL126W	YGL126W	"SCS3 - Protein required for inositol prototrophy, identified as an ortholog of the FIT family of proteins involved in triglyceride droplet biosynthesis; disputed role in the synthesis of inositol phospholipids from inositol"	1	0	0	0	0	0	0.2	0
4460_OG5_175812_7 - FUNGI_YOR023C	YOR023C	"AHC1 - Subunit of the Ada histone acetyltransferase complex, required for structural integrity of the complex"	1	0	0	0	0	0	0.2	0
4461_OG5_175865_7 - FUNGI_YAL018C	YAL018C	YAL018C - Putative protein of unknown function	1	0	0	0	0	0	0.2	0
4462_OG5_175892_7 - FUNGI_YPR095C	YPR095C	"SYT1 - Guanine nucleotide exchange factor (GEF) for Arf proteins; promotes activation of Arl1p, which recruits Imh1p to the Golgi; involved in vesicular transport; member of the Sec7-domain family; contains a PH domain"	1	0	0	0	0	0	0.2	0
4463_OG5_175908_7 - FUNGI_YDR137W	YDR137W	RGP1 - Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) that catalyzes nucleotide exchange on Ypt6p	1	0	0	0	0	0	0.2	0
4464_OG5_175994_7 - FUNGI_YML071C	YML071C	"COG8 - Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments"	1	0	0	0	0	0	0.2	0
4465_OG5_176001_7 - FUNGI_YPL159C	YPL159C	"PET20 - Mitochondrial protein, required for respiratory growth under some conditions and for stability of the mitochondrial genome"	1	0	0	0	0	0	0.2	0
4466_OG5_176024_7 - FUNGI_YHR192W	YHR192W	YHR192W - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS	1	0	0	0	0	0	0.2	0
4467_OG5_176035_7 - FUNGI_YGL151W	YGL151W	"NUT1 - Component of the RNA polymerase II mediator complex, which is required for transcriptional activation and also has a role in basal transcription"	1	0	0	0	0	0	0.2	0
4468_OG5_176126_7 - FUNGI_YDR171W	YDR171W	HSP42 - Small heat shock protein (sHSP) with chaperone activity; forms barrel-shaped oligomers that suppress unfolded protein aggregation; involved in cytoskeleton reorganization after heat shock	1	0	0	0	0	0	0.2	0
4469_OG5_176197_7 - FUNGI_YOR107W	YOR107W	RGS2 - Negative regulator of glucose-induced cAMP signaling; directly activates the GTPase activity of the heterotrimeric G protein alpha subunit Gpa2p	1	0	0	0	0	0	0.2	0
4470_OG5_176201_7 - FUNGI_YIR017C	YIR017C	"MET28 - Basic leucine zipper (bZIP) transcriptional activator in the Cbf1p-Met4p-Met28p complex, participates in the regulation of sulfur metabolism"	1	0	0	0	0	0	0.2	0
4471_OG5_176218_7 - FUNGI_YNL187W	YNL187W	SWT21 - Protein involved in mRNA splicing; contains a consensus nuclear export signal (NES) sequence similar to the consensus sequence recognized by Crm1p; interacts genetically with Prp40p and Tgs1p; contains WD40 repeats	1	0	0	0	0	0	0.2	0
4472_OG5_176232_7 - FUNGI_YBR156C	YBR156C	"SLI15 - Subunit of the conserved chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), which regulates kinetochore-microtubule attachments, activation of the spindle tension checkpoint, and mitotic spindle disassembly"	1	0	0	0	0	0	0.2	0
4473_OG5_176255_7 - FUNGI_YHR103W	YHR103W	SBE22 - Protein involved in the transport of cell wall components from the Golgi to the cell surface; similar in structure and functionally redundant with Sbe2p; involved in bud growth	1	0	0	0	0	0	0.2	0
4474_OG5_176286_7 - FUNGI_YFL040W	YFL040W	"YFL040W - Putative transporter, member of the sugar porter family; YFL040W is not an essential gene"	1	0	0	0	0	0	0.2	0
4475_OG5_176305_7 - FUNGI_YKL162C	YKL162C	YKL162C - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion	1	0	0	0	0	0	0.2	0
4476_OG5_176536_7 - FUNGI_YER054C	YER054C	"GIP2 - Putative regulatory subunit of the protein phosphatase Glc7p, involved in glycogen metabolism; contains a conserved motif (GVNK motif) that is also found in Gac1p, Pig1p, and Pig2p"	1	0	0	0	0	0	0.2	0
4477_OG5_176549_7 - FUNGI_YIL136W	YIL136W	"OM45 - Protein of unknown function, major constituent of the mitochondrial outer membrane; located on the outer (cytosolic) face of the outer membrane"	1	0	0	0	0	0	0.2	0
4478_OG5_176707_7 - FUNGI_YGL128C	YGL128C	"CWC23 - Component of a complex containing Cef1p, putatively involved in pre-mRNA splicing; has similarity to E. coli DnaJ and other DnaJ-like proteins and to S. pombe Cwf23p"	1	0	0	0	0	0	0.2	0
4479_OG5_176740_7 - FUNGI_YPR010C-A	YPR010C-A	YPR010C-A - Putative protein of unknown function; conserved among Saccharomyces sensu stricto species	1	0	0	0	0	0	0.2	0
4480_OG5_176753_7 - FUNGI_YGL227W	YGL227W	"VID30 - Protein involved in proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBPase); binds FBPase; shifts the balance of nitrogen metabolism toward glutamate production; localizes to the nucleus and the cytoplasm"	1	0	0	0	0	0	0.2	0
4481_OG5_176777_7 - FUNGI_YLL004W	YLL004W	"ORC3 - Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing"	1	0	0	0	0	0	0.2	0
4482_OG5_176779_7 - FUNGI_YLR132C	YLR132C	"YLR132C - Essential protein of unknown function; fluorescent protein (GFP or YFP)-tagged protein localizes to mitochondria, cytoplasm and nucleus"	1	0	0	0	0	0	0.2	0
4483_OG5_176781_7 - FUNGI_YLR035C	YLR035C	MLH2 - Protein involved in the mismatch repair of certain frameshift intermediates and involved in meiotic recombination; forms a complex with Mlh1p	1	0	0	0	0	0	0.2	0
4484_OG5_176811_7 - FUNGI_YDR106W	YDR106W	"ARP10 - Component of the dynactin complex, localized to the pointed end of the Arp1p filament; may regulate membrane association of the complex"	1	0	0	0	0	0	0.2	0
4485_OG5_176829_7 - FUNGI_YOR221C	YOR221C	"MCT1 - Predicted malonyl-CoA:ACP transferase, putative component of a type-II mitochondrial fatty acid synthase that produces intermediates for phospholipid remodeling"	1	0	0	0	0	0	0.2	0
4486_OG5_176832_7 - FUNGI_YLR173W	YLR173W	YLR173W - Putative protein of unknown function	1	0	0	0	0	0	0.2	0
4487_OG5_176852_7 - FUNGI_YDR124W	YDR124W	YDR124W - Putative protein of unknown function; non-essential gene; expression is strongly induced by alpha factor	1	0	0	0	0	0	0.2	0
4488_OG5_176884_7 - FUNGI_YKL074C	YKL074C	"MUD2 - Protein involved in early pre-mRNA splicing; component of the pre-mRNA-U1 snRNP complex, the commitment complex; interacts with Msl5p/BBP splicing factor and Sub2p; similar to metazoan splicing factor U2AF65"	1	0	0	0	0	0	0.2	0
4489_OG5_176919_7 - FUNGI_YDR391C	YDR391C	"YDR391C - Putative protein of unknown function, possibly involved in zinc homeostasis; Bdf1p-dependent transcription induced by salt stress; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus"	1	0	0	0	0	0	0.2	0
4490_OG5_176972_7 - FUNGI_YHR017W	YHR017W	"YSC83 - Non-essential mitochondrial protein of unknown function; mRNA induced during meiosis, peaking between mid to late prophase of meiosis I; similar to S. douglasii YSD83"	1	0	0	0	0	0	0.2	0
4491_OG5_176984_7 - FUNGI_YJL146W	YJL146W	"IDS2 - Protein involved in modulation of Ime2p activity during meiosis, appears to act indirectly to promote Ime2p-mediated late meiotic functions; found in growing cells and degraded during sporulation"	1	0	0	0	0	0	0.2	0
4492_OG5_176987_7 - FUNGI_YGR089W	YGR089W	"NNF2 - Protein that exhibits physical and genetic interactions with Rpb8p, which is a subunit of RNA polymerases I, II, and III; computational analysis of large-scale protein-protein interaction data suggests a role in chromosome segregation"	1	0	0	0	0	0	0.2	0
4493_OG5_177187_7 - FUNGI_YBL081W	YBL081W	YBL081W - Non-essential protein of unknown function; null mutation results in a decrease in plasma membrane electron transport	1	0	0	0	0	0	0.2	0
4494_OG5_177189_7 - FUNGI_YDR110W	YDR110W	"FOB1 - Nucleolar protein that binds the rDNA replication fork barrier (RFB) site; required for replication fork blocking, recombinational hotspot activity, condensin recruitment to RFB and rDNA repeat segregation; related to retroviral integrases"	1	0	0	0	0	0	0.2	0
4495_OG5_177202_7 - FUNGI_YIL017C	YIL017C	"VID28 - Protein involved in proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBPase); localized to the nucleus and the cytoplasm"	1	0	0	0	0	0	0.2	0
4496_OG5_177616_7 - FUNGI_YDR356W	YDR356W	"SPC110 - Inner plaque spindle pole body (SPB) component, ortholog of human kendrin; involved in connecting nuclear microtubules to SPB; interacts with Tub4p-complex and calmodulin; phosphorylated by Mps1p in cell cycle-dependent manner"	1	0	0	0	0	0	0.2	0
4497_OG5_177673_7 - FUNGI_YPR093C	YPR093C	ASR1 - Ubiquitin ligase that modifies and regulates RNA Pol II; involved in a putative alcohol-responsive signaling pathway; accumulates in the nucleus under alcohol stress; contains a Ring/PHD finger domain similar to the mammalian rA9 protein	1	0	0	0	0	0	0.2	0
4498_OG5_178544_7 - FUNGI_YAR019C	YAR019C	CDC15 - Protein kinase of the Mitotic Exit Network that is localized to the spindle pole bodies at late anaphase; promotes mitotic exit by directly switching on the kinase activity of Dbf2p; required for spindle disassembly after meiosis II	1	0	0	0	0	0	0.2	0
4499_OG5_178780_7 - FUNGI_YGR130C	YGR130C	YGR130C - Component of the eisosome with unknown function; GFP-fusion protein localizes to the cytoplasm; specifically phosphorylated in vitro by mammalian diphosphoinositol pentakisphosphate (IP7)	1	0	0	0	0	0	0.2	0
4500_OG5_178797_7 - FUNGI_YDR076W	YDR076W	RAD55 - Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad57p	1	0	0	0	0	0	0.2	0
4501_OG5_178841_7 - FUNGI_YBR119W	YBR119W	"MUD1 - U1 snRNP A protein, homolog of human U1-A; involved in nuclear mRNA splicing"	1	0	0	0	0	0	0.2	0
4502_OG5_179001_7 - FUNGI_YGR075C	YGR075C	"PRP38 - Unique component of the U4/U6.U5 tri-snRNP particle, required for conformational changes which result in the catalytic activation of the spliceosome; dispensible for spliceosome assembly"	1	0	0	0	0	0	0.2	0
4503_OG5_179010_7 - FUNGI_YKR008W	YKR008W	RSC4 - Component of the RSC chromatin remodeling complex; found in close proximity to nucleosomal DNA; displaced from the surface of nucleosomal DNA after chromatin remodeling	1	0	0	0	0	0	0.2	0
4504_OG5_179023_7 - FUNGI_YJL019W	YJL019W	MPS3 - Nuclear envelope protein required for SPB duplication and nuclear fusion; localizes to the SPB half bridge and at telomeres during meiosis; required with Ndj1p and Csm4p for meiotic bouquet formation and telomere-led rapid prophase movement	1	0	0	0	0	0	0.2	0
4505_OG5_179390_7 - FUNGI_YPL108W	YPL108W	YPL108W - Cytoplasmic protein of unknown function; non-essential gene that is induced in a GDH1 deleted strain with altered redox metabolism; GFP-fusion protein is induced in response to the DNA-damaging agent MMS	1	0	0	0	0	0	0.2	0
4506_OG5_179411_7 - FUNGI_YDL203C	YDL203C	ACK1 - Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria	1	0	0	0	0	0	0.2	0
4507_OG5_179447_7 - FUNGI_YDL005C	YDL005C	MED2 - Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation	1	0	0	0	0	0	0.2	0
4508_OG5_179449_7 - FUNGI_YPL005W	YPL005W	AEP3 - Protein that may facilitate use of unformylated tRNA-Met in mitochondrial translation initiation; localized to the matrix face of the mitochondrial inner membrane; stabilizes the bicistronic AAP1-ATP6 mRNA	1	0	0	0	0	0	0.2	0
4509_OG5_179488_7 - FUNGI_YOR342C	YOR342C	YOR342C - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus	1	0	0	0	0	0	0.2	0
4510_OG5_179493_7 - FUNGI_YGL226W	YGL226W	MTC3 - Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; mtc3 is synthetically sick with cdc13-1	1	0	0	0	0	0	0.2	0
4511_OG5_179525_7 - FUNGI_YJR043C	YJR043C	"POL32 - Third subunit of DNA polymerase delta, involved in chromosomal DNA replication; required for error-prone DNA synthesis in the presence of DNA damage and processivity; interacts with Hys2p, PCNA (Pol30p), and Pol1p"	1	0	0	0	0	0	0.2	0
4512_OG5_179532_7 - FUNGI_YBR264C	YBR264C	YPT10 - Rab family GTP-binding protein that contains the PEST signal sequence specific for proteolytic enzymes; may be involved in vesicular transport; overexpression leads to accumulation of Golgi-like cisternae with budding vesicles	1	0	0	0	0	0	0.2	0
4513_OG5_179533_7 - FUNGI_YGR166W	YGR166W	"TRS65 - Subunit of TRAPPII, a multimeric guanine nucleotide-exchange factor for Ypt1p; involved in intra-Golgi traffic and the retrograde pathway from the endosome to Golgi; role in cell wall beta-glucan biosynthesis and the stress response"	1	0	0	0	0	0	0.2	0
4514_OG5_179547_7 - FUNGI_YLR436C	YLR436C	"ECM30 - Putative protein of unknown function; may play a role in cell wall biosynthesis, mutants have abormal relative levels of mannose and glucose and have Gap1p sorting and transport defects; (GFP)-fusion protein localizes to the cytoplasm"	1	0	0	0	0	0	0.2	0
4515_OG5_179562_7 - FUNGI_YER079W	YER079W	YER079W - Putative protein of unknown function	1	0	0	0	0	0	0.2	0
4516_OG5_179571_7 - FUNGI_YJR053W	YJR053W	BFA1 - Component of the GTPase-activating Bfa1p-Bub2p complex involved in multiple cell cycle checkpoint pathways that control exit from mitosis	1	0	0	0	0	0	0.2	0
4517_OG5_179575_7 - FUNGI_YLR095C	YLR095C	"IOC2 - Member of a complex (Isw1b) with Isw1p and Ioc4p that exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing, contains a PHD finger motif"	1	0	0	0	0	0	0.2	0
4518_OG5_179592_7 - FUNGI_YGR120C	YGR120C	"COG2 - Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments"	1	0	0	0	0	0	0.2	0
4519_OG5_179595_7 - FUNGI_YMR098C	YMR098C	ATP25 - Mitochondrial protein required for the stability of Oli1p (Atp9p) mRNA and for the Oli1p ring formation; YMR098C is not an essential gene	1	0	0	0	0	0	0.2	0
4520_OG5_179614_7 - FUNGI_YJL044C	YJL044C	"GYP6 - GTPase-activating protein (GAP) for the yeast Rab family member, Ypt6p; involved in vesicle mediated protein transport"	1	0	0	0	0	0	0.2	0
4521_OG5_179644_7 - FUNGI_YDR495C	YDR495C	"VPS3 - Component of CORVET tethering complex; cytoplasmic protein required for the sorting and processing of soluble vacuolar proteins, acidification of the vacuolar lumen, and assembly of the vacuolar H+-ATPase"	1	0	0	0	0	0	0.2	0
4522_OG5_179663_7 - FUNGI_YPL193W	YPL193W	RSA1 - Protein involved in the assembly of 60S ribosomal subunits; functionally interacts with Dbp6p; functions in a late nucleoplasmic step of the assembly	1	0	0	0	0	0	0.2	0
4523_OG5_179665_7 - FUNGI_YGR212W	YGR212W	"SLI1 - N-acetyltransferase, confers resistance to the sphingolipid biosynthesis inhibitor myriocin (ISP-1) by converting it into N-acetyl-myriocin, co-operates with Ypk1p in mediating resistance to myriocin"	1	0	0	0	0	0	0.2	0
4524_OG5_179669_7 - FUNGI_YHL034C	YHL034C	SBP1 - Putative RNA binding protein; involved in translational repression and found in cytoplasmic P bodies; found associated with small nucleolar RNAs snR10 and snR11	1	0	0	0	0	0	0.2	0
4525_OG5_179677_7 - FUNGI_YLR431C	YLR431C	ATG23 - Peripheral membrane protein required for the cytoplasm-to-vacuole targeting (Cvt) pathway and efficient macroautophagy; cycles between the phagophore assembly site (PAS) and non-PAS locations; forms a complex with Atg9p and Atg27p	1	0	0	0	0	0	0.2	0
4526_OG5_179691_7 - FUNGI_YMR282C	YMR282C	"AEP2 - Mitochondrial protein, likely involved in translation of the mitochondrial OLI1 mRNA; exhibits genetic interaction with the OLI1 mRNA 5'-untranslated leader"	1	0	0	0	0	0	0.2	0
4527_OG5_179693_7 - FUNGI_YLL038C	YLL038C	"ENT4 - Protein of unknown function, contains an N-terminal epsin-like domain; proposed to be involved in the trafficking of Arn1p in the absence of ferrichrome"	1	0	0	0	0	0	0.2	0
4528_OG5_179700_7 - FUNGI_YIL154C	YIL154C	"IMP2' - Transcriptional activator involved in maintenance of ion homeostasis and protection against DNA damage caused by bleomycin and other oxidants, contains a C-terminal leucine-rich repeat"	1	0	0	0	0	0	0.2	0
4529_OG5_179710_7 - FUNGI_YMR134W	YMR134W	YMR134W - Protein of unknown function that may be involved in iron metabolism; mutant bm-8 has a growth defect on iron-limited medium that is complemented by overexpression of Yfh1p; shows localization to the ER; highly conserved in ascomycetes	1	0	0	0	0	0	0.2	0
4530_OG5_179715_7 - FUNGI_YKL042W	YKL042W	"SPC42 - Central plaque component of spindle pole body (SPB); involved in SPB duplication, may facilitate attachment of the SPB to the nuclear membrane"	1	0	0	0	0	0	0.2	0
4531_OG5_179716_7 - FUNGI_YDL089W	YDL089W	"NUR1 - Protein of unknown function; interacts with Csm1p, Lrs4p; required for rDNA repeat stability; null mutant causes increase in unequal sister-chromatid exchange; GFP-fusion protein localizes to the nuclear periphery, possible Cdc28p substrate"	1	0	0	0	0	0	0.2	0
4532_OG5_179720_7 - FUNGI_YLR135W	YLR135W	SLX4 - Endonuclease involved in processing DNA during recombination and repair; cleaves branched structures in a complex with Slx1p; involved in Rad1p/Rad10p-dependent removal of 3'-nonhomologous tails during DSBR via single-strand annealing	1	0	0	0	0	0	0.2	0
4533_OG5_179732_7 - FUNGI_YGR198W	YGR198W	YPP1 - Cargo-transport protein involved in endocytosis; interacts with phosphatidylinositol-4-kinase Stt4; GFP-fusion protein localizes to the cytoplasm; YGR198W is an essential gene	1	0	0	0	0	0	0.2	0
4534_OG5_179747_7 - FUNGI_YKR007W	YKR007W	"MEH1 - Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; loss results in a defect in vacuolar acidification"	1	0	0	0	0	0	0.2	0
4535_OG5_179758_7 - FUNGI_YER033C	YER033C	"ZRG8 - Protein of unknown function; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; GFP-fusion protein is localized to the cytoplasm; transcription induced under conditions of zinc deficiency"	1	0	0	0	0	0	0.2	0
4536_OG5_179763_7 - FUNGI_YJL016W	YJL016W	YJL016W - Putative protein of unknown function; GFP-fusion protein localizes to the cytoplasm; conserved in closely related Saccharomyces species	1	0	0	0	0	0	0.2	0
4537_OG5_179765_7 - FUNGI_YCL044C	YCL044C	"MGR1 - Subunit of the mitochondrial (mt) i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr3p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA"	1	0	0	0	0	0	0.2	0
4538_OG5_179773_7 - FUNGI_YLR018C	YLR018C	POM34 - Integral membrane protein of the nuclear pore; has an important role in maintaining the architecture of the pore complex	1	0	0	0	0	0	0.2	0
4539_OG5_179783_7 - FUNGI_YJR046W	YJR046W	"TAH11 - DNA replication licensing factor, required for pre-replication complex assembly"	1	0	0	0	0	0	0.2	0
4540_OG5_179793_7 - FUNGI_YBL031W	YBL031W	"SHE1 - Mitotic spindle protein that interacts with components of the Dam1 (DASH) complex, its effector Sli15p, and microtubule-associated protein Bim1p; also localizes to nuclear microtubules and to the bud neck in a ring-shaped structure"	1	0	0	0	0	0	0.2	0
4541_OG5_179800_7 - FUNGI_YBR129C	YBR129C	"OPY1 - Protein of unknown function, overproduction blocks cell cycle arrest in the presence of mating pheromone; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"	1	0	0	0	0	0	0.2	0
4542_OG5_179802_7 - FUNGI_YLR226W	YLR226W	BUR2 - Cyclin for the Sgv1p (Bur1p) protein kinase; Sgv1p and Bur2p comprise a CDK-cyclin complex involved in transcriptional regulation through its phosphorylation of the carboxy-terminal domain of the largest subunit of RNA polymerase II	1	0	0	0	0	0	0.2	0
4543_OG5_179813_7 - FUNGI_YGL145W	YGL145W	TIP20 - Peripheral membrane protein required for fusion of COPI vesicles with the ER; prohibits back-fusion of COPII vesicles with the ER; forms a tethering complex with Sec39p and Dsl1p that interacts with ER SNAREs Sec20p and Use1p	1	0	0	0	0	0	0.2	0
4544_OG5_179820_7 - FUNGI_YJL061W	YJL061W	"NUP82 - Nucleoporin, subunit of the nuclear pore complex (NPC); forms a subcomplex with Gle2p, Nup159p, Nsp1p, and Nup116p and is required for proper localization of Nup116p in the NPC"	1	0	0	0	0	0	0.2	0
4545_OG5_179830_7 - FUNGI_YKL098W	YKL098W	MTC2 - Protein of unknown function; mtc2 is synthetically sick with cdc13-1	1	0	0	0	0	0	0.2	0
4546_OG5_179833_7 - FUNGI_YPR057W	YPR057W	"BRR1 - snRNP protein component of spliceosomal snRNPs, required for pre-mRNA splicing and snRNP biogenesis; in null mutant newly-synthesized snRNAs are destabilized and 3'-end processing is slowed"	1	0	0	0	0	0	0.2	0
4547_OG5_179853_7 - FUNGI_YMR204C	YMR204C	INP1 - Peripheral membrane protein of peroxisomes involved in peroxisomal inheritance; recruitment to peroxisomes is mediated by interaction with Pex3p at the peroxisomal membrane	1	0	0	0	0	0	0.2	0
4548_OG5_179861_7 - FUNGI_YLL003W	YLL003W	"SFI1 - Centrin (Cdc31p)-binding protein required for spindle pole body (SPB) duplication, localizes to the half-bridge of the SPB, required for progression through G(2)-M transition, has similarity to Xenopus laevis XCAP-C"	1	0	0	0	0	0	0.2	0
4549_OG5_179872_7 - FUNGI_YFR013W	YFR013W	"IOC3 - Member of a complex (Isw1a) with Isw1p that has nucleosome-stimulated ATPase activity and represses transcription initiation by specific positioning of a promoter proximal dinucleosome; has homology to Esc8p, which is involved in silencing"	1	0	0	0	0	0	0.2	0
4550_OG5_179873_7 - FUNGI_YGL071W	YGL071W	AFT1 - Transcription factor involved in iron utilization and homeostasis; binds the consensus site PyPuCACCCPu and activates the expression of target genes in response to changes in iron availability	1	0	0	0	0	0	0.2	0
4551_OG5_179885_7 - FUNGI_YIL139C	YIL139C	"REV7 - Accessory subunit of DNA polymerase zeta, involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair"	1	0	0	0	0	0	0.2	0
4552_OG5_179898_7 - FUNGI_YDR179W-A	YDR179W-A	YDR179W-A - Putative protein of unknown function	1	0	0	0	0	0	0.2	0
4553_OG5_179899_7 - FUNGI_YJL051W	YJL051W	"IRC8 - Bud tip localized protein of unknown function; mRNA is targeted to the bud by a She2p dependent transport system; mRNA is cell cycle regulated via Fkh2p, peaking in G2/M phase; null mutant displays increased levels of spontaneous Rad52p foc"	1	0	0	0	0	0	0.2	0
4554_OG5_179901_7 - FUNGI_YFR049W	YFR049W	"YMR31 - Mitochondrial ribosomal protein of the small subunit, has similarity to human mitochondrial ribosomal protein MRP-S36"	1	0	0	0	0	0	0.2	0
4555_OG5_179902_7 - FUNGI_YKL057C	YKL057C	"NUP120 - Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC), required for even distribution of NPCs around the nuclear envelope, involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p"	1	0	0	0	0	0	0.2	0
4556_OG5_179905_7 - FUNGI_YBL060W	YBL060W	YEL1 - Guanine nucleotide exchange factor specific for Arf3p; localized to the bud neck and tip; required for localization of Arf3p to the bud neck and tip	1	0	0	0	0	0	0.2	0
4557_OG5_179906_7 - FUNGI_YLR219W	YLR219W	"MSC3 - Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; msc3 mutants are defective in directing meiotic recombination events to homologous chromatids; potential Cdc28p substrate"	1	0	0	0	0	0	0.2	0
4558_OG5_179907_7 - FUNGI_YMR029C	YMR029C	"FAR8 - Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far9p, Far10p, and Far11p"	1	0	0	0	0	0	0.2	0
4559_OG5_180234_7 - FUNGI_YOL126C	YOL126C	"MDH2 - Cytoplasmic malate dehydrogenase, one of three isozymes that catalyze interconversion of malate and oxaloacetate; involved in the glyoxylate cycle and gluconeogenesis during growth on two-carbon compounds; interacts with Pck1p and Fbp1"	1	0	0	0	0	0	0.2	0
4560_OG5_180325_7 - FUNGI_YLR320W	YLR320W	MMS22 - Protein that acts with Mms1p in a repair pathway that may be involved in resolving replication intermediates or preventing the damage caused by blocked replication forks; required for accurate meiotic chromosome segregation	1	0	0	0	0	0	0.2	0
4561_OG5_180326_7 - FUNGI_YGL036W	YGL036W	YGL036W - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YGL036W is not an essential gene	1	0	0	0	0	0	0.2	0
4562_OG5_180327_7 - FUNGI_YDR350C	YDR350C	"ATP22 - Specific translational activator for the mitochondrial ATP6 mRNA, encoding a subunit of F1F0 ATP synthase; localized to the mitochondrial inner membrane"	1	0	0	0	0	0	0.2	0
4563_OG5_180328_7 - FUNGI_YDR369C	YDR369C	"XRS2 - Protein required for DNA repair; component of the Mre11 complex, which is involved in double strand breaks, meiotic recombination, telomere maintenance, and checkpoint signaling"	1	0	0	0	0	0	0.2	0
4564_OG5_180329_7 - FUNGI_YDR370C	YDR370C	YDR370C - Putative protein of unknown function	1	0	0	0	0	0	0.2	0
4565_OG5_180330_7 - FUNGI_YDR381C-A	YDR381C-A	"YDR381C-A - Protein of unknown function, localized to the mitochondrial outer membrane"	1	0	0	0	0	0	0.2	0
4566_OG5_180331_7 - FUNGI_YDR384C	YDR384C	"ATO3 - Plasma membrane protein, regulation pattern suggests a possible role in export of ammonia from the cell; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family of putative transporters"	1	0	0	0	0	0	0.2	0
4567_OG5_180333_7 - FUNGI_YLR039C	YLR039C	RIC1 - Protein involved in retrograde transport to the cis-Golgi network; forms heterodimer with Rgp1p that acts as a GTP exchange factor for Ypt6p; involved in transcription of rRNA and ribosomal protein genes	1	0	0	0	0	0	0.2	0
4568_OG5_180334_7 - FUNGI_YLR204W	YLR204W	"QRI5 - Mitochondrial inner membrane protein, required for accumulation of spliced COX1 mRNA; may have an additional role in translation of COX1 mRNA"	1	0	0	0	0	0	0.2	0
4569_OG5_180335_7 - FUNGI_YLR199C	YLR199C	PBA1 - Protein involved in 20S proteasome assembly; forms a heterodimer with Add66p that binds to proteasome precursors; similar to human PAC1 constituent of the PAC1-PAC2 complex involved in proteasome assembly	1	0	0	0	0	0	0.2	0
4570_OG5_180336_7 - FUNGI_YCL058W-A	YCL058W-A	ADF1 - Transcriptional repressor encoded by the antisense strand of the FYV5 gene; negatively regulates transcription of FYV5 by binding to the promoter on the sense strand	1	0	0	0	0	0	0.2	0
4571_OG5_180337_7 - FUNGI_YCL051W	YCL051W	LRE1 - Protein involved in control of cell wall structure and stress response; overproduction confers resistance to cell-wall degrading enzymes; exhibits genetic interactions with genes involved in the cell wall integrity pathway	1	0	0	0	0	0	0.2	0
4572_OG5_180338_7 - FUNGI_YDR138W	YDR138W	"HPR1 - Subunit of THO/TREX complexes that couple transcription elongation with mitotic recombination and with mRNA metabolism and export, subunit of an RNA Pol II complex; regulates lifespan; involved in telomere maintenance; similar to Top1p"	1	0	0	0	0	0	0.2	0
4573_OG5_180339_7 - FUNGI_YDR118W	YDR118W	"APC4 - Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis"	1	0	0	0	0	0	0.2	0
4574_OG5_180340_7 - FUNGI_YDR123C	YDR123C	"INO2 - Component of the heteromeric Ino2p/Ino4p basic helix-loop-helix transcription activator that binds inositol/choline-responsive elements (ICREs), required for derepression of phospholipid biosynthetic genes in response to inositol depletion"	1	0	0	0	0	0	0.2	0
4575_OG5_180341_7 - FUNGI_YDR130C	YDR130C	FIN1 - Spindle pole body-related intermediate filament protein; forms cell cycle-specific filaments between spindle pole bodies in mother and daughter cells; localization cell-cycle dependent; involved in Glc7p localization and regulation	1	0	0	0	0	0	0.2	0
4576_OG5_180342_7 - FUNGI_YGR222W	YGR222W	PET54 - Mitochondrial inner membrane protein; binds to the 5' UTR of the COX3 mRNA to activate its translation together with Pet122p and Pet494p; also binds to the COX1 Group I intron AI5 beta to facilitate exon ligation during splicing	1	0	0	0	0	0	0.2	0
4577_OG5_180343_7 - FUNGI_YML119W	YML119W	YML119W - Putative protein of unknown function; YML119W is not an essential gene; potential Cdc28p substrate	1	0	0	0	0	0	0.2	0
4578_OG5_180344_7 - FUNGI_YLR360W	YLR360W	VPS38 - Part of a Vps34p phosphatidylinositol 3-kinase complex that functions in carboxypeptidase Y (CPY) sorting; binds Vps30p and Vps34p to promote production of phosphatidylinositol 3-phosphate (PtdIns3P) which stimulates kinase activity	1	0	0	0	0	0	0.2	0
4579_OG5_180345_7 - FUNGI_YKR011C	YKR011C	YKR011C - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus	1	0	0	0	0	0	0.2	0
4580_OG5_180346_7 - FUNGI_YBR275C	YBR275C	RIF1 - Protein that binds to the Rap1p C-terminus and acts synergistically with Rif2p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation	1	0	0	0	0	0	0.2	0
4581_OG5_180348_7 - FUNGI_YCL005W	YCL005W	LDB16 - Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria	1	0	0	0	0	0	0.2	0
4582_OG5_180349_7 - FUNGI_YJL173C	YJL173C	"RFA3 - Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination"	1	0	0	0	0	0	0.2	0
4583_OG5_180350_7 - FUNGI_YLR094C	YLR094C	GIS3 - Protein of unknown function	1	0	0	0	0	0	0.2	0
4584_OG5_180351_7 - FUNGI_YBR131W	YBR131W	"CCZ1 - Protein involved in vacuolar assembly, essential for autophagy and the cytoplasm-to-vacuole pathway"	1	0	0	0	0	0	0.2	0
4585_OG5_180352_7 - FUNGI_YBR128C	YBR128C	ATG14 - Autophagy-specific subunit of phosphatidylinositol 3-kinase complex I (with Vps34/15/30p); Atg14p targets complex I to the phagophore assembly site (PAS); required for localizing additional ATG proteins to the PAS; homolog of human Barkor	1	0	0	0	0	0	0.2	0
4586_OG5_180353_7 - FUNGI_YFR042W	YFR042W	"KEG1 - Integral membrane protein of the ER; physically interacts with Kre6p; has a role in the synthesis of beta-1,6-glucan in the cell wall; required for cell viability"	1	0	0	0	0	0	0.2	0
4587_OG5_180354_7 - FUNGI_YER038C	YER038C	"KRE29 - Essential subunit of the Mms21-Smc5-Smc6 complex, required for growth and DNA repair; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance"	1	0	0	0	0	0	0.2	0
4588_OG5_180355_7 - FUNGI_YER034W	YER034W	YER034W - Putative protein of unknown function; non-essential gene; expression induced upon calcium shortage	1	0	0	0	0	0	0.2	0
4589_OG5_180356_7 - FUNGI_YLL042C	YLL042C	"ATG10 - Conserved E2-like conjugating enzyme that mediates formation of the Atg12p-Atg5p conjugate, which is a critical step in autophagy"	1	0	0	0	0	0	0.2	0
4590_OG5_180357_7 - FUNGI_YNR045W	YNR045W	"PET494 - Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet122p; located in the mitochondrial inner membrane"	1	0	0	0	0	0	0.2	0
4591_OG5_180358_7 - FUNGI_YIL009C-A	YIL009C-A	"EST3 - Component of the telomerase holoenzyme, involved in telomere replication"	1	0	0	0	0	0	0.2	0
4592_OG5_180359_7 - FUNGI_YOL063C	YOL063C	CRT10 - Protein involved in transcriptional regulation of RNR2 and RNR3; expression of the gene is induced by DNA damage and null mutations confer increased resistance to hydroxyurea; N-terminal region has a leucine repeat and a WD40 repeat	1	0	0	0	0	0	0.2	0
4593_OG5_180360_7 - FUNGI_YKL187C	YKL187C	"YKL187C - Putative protein of unknown function; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies"	1	0	0	0	0	0	0.2	0
4594_OG5_180361_7 - FUNGI_YDL073W	YDL073W	YDL073W - Putative protein of unknown function; YDL073W is not an essential gene	1	0	0	0	0	0	0.2	0
4595_OG5_180362_7 - FUNGI_YPR070W	YPR070W	MED1 - Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation	1	0	0	0	0	0	0.2	0
4596_OG5_180363_7 - FUNGI_YOR354C	YOR354C	"MSC6 - Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"	1	0	0	0	0	0	0.2	0
4597_OG5_180365_7 - FUNGI_YLL033W	YLL033W	IRC19 - Putative protein of unknown function; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spontaneous Rad52p foci	1	0	0	0	0	0	0.2	0
4598_OG5_180367_7 - FUNGI_YHR035W	YHR035W	YHR035W - Putative protein of unknown function; not an essential gene	1	0	0	0	0	0	0.2	0
4599_OG5_180368_7 - FUNGI_YPR116W	YPR116W	"RRG8 - Putative protein of unknown function, required for mitochondrial genome maintenance; null mutation results in a decrease in plasma membrane electron transport"	1	0	0	0	0	0	0.2	0
4600_OG5_180369_7 - FUNGI_YBR253W	YBR253W	SRB6 - Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation	1	0	0	0	0	0	0.2	0
4601_OG5_180372_7 - FUNGI_YCR082W	YCR082W	"AHC2 - Protein of unknown function, putative transcriptional regulator; proposed to be a Ada Histone acetyltransferase complex component; GFP tagged protein is localized to the cytoplasm and nucleus"	1	0	0	0	0	0	0.2	0
4602_OG5_180373_7 - FUNGI_YDR156W	YDR156W	RPA14 - RNA polymerase I subunit A14	1	0	0	0	0	0	0.2	0
4603_OG5_180374_7 - FUNGI_YDR153C	YDR153C	"ENT5 - Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p, clathrin adaptor complex AP-1, and clathrin"	1	0	0	0	0	0	0.2	0
4604_OG5_180375_7 - FUNGI_YOL136C	YOL136C	"PFK27 - 6-phosphofructo-2-kinase, catalyzes synthesis of fructose-2,6-bisphosphate; inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate, expression induced by glucose and sucrose, transcriptional regulation involves protein kinase A"	1	0	0	0	0	0	0.2	0
4605_OG5_180376_7 - FUNGI_YOL117W	YOL117W	RRI2 - Subunit of the COP9 signalosome (CSN) complex that cleaves the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; plays a role in the mating pheromone response	1	0	0	0	0	0	0.2	0
4606_OG5_180378_7 - FUNGI_YBL006C	YBL006C	"LDB7 - Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions"	1	0	0	0	0	0	0.2	0
4607_OG5_180380_7 - FUNGI_YDR056C	YDR056C	YDR056C - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDR056C is not an essential protein	1	0	0	0	0	0	0.2	0
4608_OG5_180381_7 - FUNGI_YDR219C	YDR219C	MFB1 - Mitochondria-associated F-box protein involved in maintenance of normal mitochondrial morphology; interacts with Skp1p through the F-box motif; preferentially localizes to the mother cell during budding	1	0	0	0	0	0	0.2	0
4609_OG5_180382_7 - FUNGI_YDR218C	YDR218C	SPR28 - Sporulation-specific homolog of the yeast CDC3/10/11/12 family of bud neck microfilament genes; meiotic septin expressed at high levels during meiotic divisions and ascospore formation	1	0	0	0	0	0	0.2	0
4610_OG5_180383_7 - FUNGI_YKL159C	YKL159C	RCN1 - Protein involved in calcineurin regulation during calcium signaling; has similarity to H. sapiens DSCR1 which is found in the Down Syndrome candidate region	1	0	0	0	0	0	0.2	0
4611_OG5_180384_7 - FUNGI_YOL044W	YOL044W	"PEX15 - Phosphorylated tail-anchored type II integral peroxisomal membrane protein required for peroxisome biogenesis, cells lacking Pex15p mislocalize peroxisomal matrix proteins to cytosol, overexpression results in impaired peroxisome assembly"	1	0	0	0	0	0	0.2	0
4612_OG5_180385_7 - FUNGI_YOL042W	YOL042W	"NGL1 - Putative endonuclease, has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"	1	0	0	0	0	0	0.2	0
4613_OG5_180386_7 - FUNGI_YOL036W	YOL036W	YOL036W - Protein of unknown function; potential Cdc28p substrate	1	0	0	0	0	0	0.2	0
4614_OG5_180387_7 - FUNGI_YLR054C	YLR054C	OSW2 - Protein of unknown function proposed to be involved in the assembly of the spore wall	1	0	0	0	0	0	0.2	0
4615_OG5_180388_7 - FUNGI_YLR052W	YLR052W	IES3 - Subunit of the INO80 chromatin remodeling complex	1	0	0	0	0	0	0.2	0
4616_OG5_180389_7 - FUNGI_YFR008W	YFR008W	"FAR7 - Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far8p, Far9p, Far10p, and Far11p"	1	0	0	0	0	0	0.2	0
4617_OG5_180390_7 - FUNGI_YMR270C	YMR270C	"RRN9 - Protein involved in promoting high level transcription of rDNA, subunit of UAF (upstream activation factor) for RNA polymerase I"	1	0	0	0	0	0	0.2	0
4618_OG5_180391_7 - FUNGI_YBL029W	YBL029W	YBL029W - Non-essential protein of unknown function	1	0	0	0	0	0	0.2	0
4619_OG5_180392_7 - FUNGI_YLR257W	YLR257W	YLR257W - Putative protein of unknown function	1	0	0	0	0	0	0.2	0
4620_OG5_180393_7 - FUNGI_YDR179C	YDR179C	"CSN9 - Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling"	1	0	0	0	0	0	0.2	0
4621_OG5_180395_7 - FUNGI_YMR064W	YMR064W	AEP1 - Protein required for expression of the mitochondrial OLI1 gene encoding subunit 9 of F1-F0 ATP synthase	1	0	0	0	0	0	0.2	0
4622_OG5_180396_7 - FUNGI_YMR066W	YMR066W	SOV1 - Mitochondrial protein of unknown function	1	0	0	0	0	0	0.2	0
4623_OG5_180397_7 - FUNGI_YIR024C	YIR024C	"YIR024C - Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; interacts with Arh1p, a mitochondrial oxidoreductase; deletion mutant has a respiratory growth defect"	1	0	0	0	0	0	0.2	0
4624_OG5_180398_7 - FUNGI_YIR025W	YIR025W	MND2 - Subunit of the anaphase-promoting complex (APC); necessary for maintaining sister chromatid cohesion in prophase I of meiosis by inhibiting premature ubiquitination and subsequent degradation of substrates by the APC(Ama1) ubiquitin ligase	1	0	0	0	0	0	0.2	0
4625_OG5_180399_7 - FUNGI_YGL061C	YGL061C	"DUO1 - Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis"	1	0	0	0	0	0	0.2	0
4626_OG5_180400_7 - FUNGI_YKL093W	YKL093W	"MBR1 - Protein involved in mitochondrial functions and stress response; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants"	1	0	0	0	0	0	0.2	0
4627_OG5_180401_7 - FUNGI_YMR168C	YMR168C	"CEP3 - Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain"	1	0	0	0	0	0	0.2	0
4628_OG5_180402_7 - FUNGI_YGR239C	YGR239C	PEX21 - Peroxin required for targeting of peroxisomal matrix proteins containing PTS2; interacts with Pex7p; partially redundant with Pex18p	1	0	0	0	0	0	0.2	0
4629_OG5_180403_7 - FUNGI_YGR275W	YGR275W	"RTT102 - Component of both the SWI/SNF and RSC chromatin remodeling complexes, suggested role in chromosome maintenance; possible weak regulator of Ty1 transposition"	1	0	0	0	0	0	0.2	0
4630_OG5_180404_7 - FUNGI_YLR329W	YLR329W	REC102 - Protein involved in early stages of meiotic recombination; required for chromosome synapsis; forms a complex with Rec104p and Spo11p necessary during the initiation of recombination	1	0	0	0	0	0	0.2	0
4631_OG5_180405_7 - FUNGI_YPR101W	YPR101W	"SNT309 - Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; interacts physically and genetically with Prp19p"	1	0	0	0	0	0	0.2	0
4632_OG5_180407_7 - FUNGI_YER104W	YER104W	RTT105 - Protein with a role in regulation of Ty1 transposition	1	0	0	0	0	0	0.2	0
4633_OG5_180408_7 - FUNGI_YER106W	YER106W	"MAM1 - Monopolin, kinetochore associated protein involved in chromosome attachment to meiotic spindle"	1	0	0	0	0	0	0.2	0
4634_OG5_180409_7 - FUNGI_YOR372C	YOR372C	NDD1 - Transcriptional activator essential for nuclear division; localized to the nucleus; essential component of the mechanism that activates the expression of a set of late-S-phase-specific genes	1	0	0	0	0	0	0.2	0
4635_OG5_180410_7 - FUNGI_YGR179C	YGR179C	"OKP1 - Outer kinetochore protein, required for accurate mitotic chromosome segregation; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) that functions as a platform for kinetochore assembly"	1	0	0	0	0	0	0.2	0
4636_OG5_180412_7 - FUNGI_YDR488C	YDR488C	"PAC11 - Dynein intermediate chain, acts in the cytoplasmic dynein pathway, forms cortical cytoplasmic microtubule capture site with Num1p; null mutant is defective in nuclear migration, essential in the absence of CIN8"	1	0	0	0	0	0	0.2	0
4637_OG5_180413_7 - FUNGI_YDR494W	YDR494W	RSM28 - Mitochondrial ribosomal protein of the small subunit; genetic interactions suggest a possible role in promoting translation initiation	1	0	0	0	0	0	0.2	0
4638_OG5_180414_7 - FUNGI_YLR368W	YLR368W	MDM30 - F-box component of an SCF ubiquitin protein ligase complex; associates with and is required for Fzo1p ubiquitination and for mitochondria fusion; stimulates nuclear export of specific mRNAs; promotes ubiquitin-mediated degradation of Gal4p in some strains	1	0	0	0	0	0	0.2	0
4639_OG5_180415_7 - FUNGI_YDR065W	YDR065W	"RRG1 - Protein of unknown function, required for vacuolar acidification and mitochondrial genome maintenance; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"	1	0	0	0	0	0	0.2	0
4640_OG5_180416_7 - FUNGI_YNL199C	YNL199C	GCR2 - Transcriptional activator of genes involved in glycolysis; interacts and functions with the DNA-binding protein Gcr1p	1	0	0	0	0	0	0.2	0
4641_OG5_180417_7 - FUNGI_YDL220C	YDL220C	"CDC13 - Single stranded DNA-binding protein found at TG1-3 telomere G-tails; regulates telomere replication through recruitment of specific sub-complexes, but the essential function is telomere capping"	1	0	0	0	0	0	0.2	0
4642_OG5_180419_7 - FUNGI_YAL027W	YAL027W	SAW1 - Protein involved in Rad1p/Rad10p-dependent removal of 3'-nonhomologous tails during double-strand break repair via single-strand annealing; green fluorescent protein (GFP)-fusion protein localizes to the nucleus	1	0	0	0	0	0	0.2	0
4643_OG5_180422_7 - FUNGI_YNL100W	YNL100W	AIM37 - Putative protein of unknown function; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays reduced respiratory growth and reduced frequency of mitochondrial genome loss	1	0	0	0	0	0	0.2	0
4644_OG5_180423_7 - FUNGI_YJL023C	YJL023C	"PET130 - Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"	1	0	0	0	0	0	0.2	0
4645_OG5_180424_7 - FUNGI_YML023C	YML023C	NSE5 - Essential subunit of the Mms21-Smc5-Smc6 complex; required for cell viability and DNA repair	1	0	0	0	0	0	0.2	0
4646_OG5_180425_7 - FUNGI_YML029W	YML029W	"USA1 - Scaffold subunit of the Hrd1p ubiquitin ligase that also promotes ligase oligomerization; involved in ER-associated protein degradation (ERAD); interacts with the U1 snRNP-specific protein, Snp1p"	1	0	0	0	0	0	0.2	0
4647_OG5_180426_7 - FUNGI_YPL168W	YPL168W	YPL168W - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; expression may be cell cycle-regulated	1	0	0	0	0	0	0.2	0
4648_OG5_180427_7 - FUNGI_YGR106C	YGR106C	"VOA1 - Endoplasmic reticulum protein that functions, together with other assembly factors, in assembly of the V0 sector of the vacuolar ATPase (V-ATPase); null mutation enhances the V-ATPase deficiency of a vma21 mutant impaired in ER retrieval"	1	0	0	0	0	0	0.2	0
4649_OG5_180428_7 - FUNGI_YIL132C	YIL132C	"CSM2 - Protein involved in a Rad51p-, Rad54p-dependent pathway for homologous recombination repair, required for accurate chromosome segregation during meiosis"	1	0	0	0	0	0	0.2	0
4650_OG5_180429_7 - FUNGI_YGR196C	YGR196C	"FYV8 - Protein of unknown function, required for survival upon exposure to K1 killer toxin"	1	0	0	0	0	0	0.2	0
4651_OG5_180430_7 - FUNGI_YLR457C	YLR457C	"NBP1 - Spindle pole body (SPB) component, required for the insertion of the duplication plaque into the nuclear membrane during SPB duplication; essential for bipolar spindle formation; component of the Mps2p-Bbp1p complex"	1	0	0	0	0	0	0.2	0
4652_OG5_180431_7 - FUNGI_YPL255W	YPL255W	"BBP1 - Protein required for the spindle pole body (SPB) duplication, localized at the central plaque periphery; forms a complex with a nuclear envelope protein Mps2p and SPB components Spc29p and Kar1p; required for mitotic functions of Cdc5p"	1	0	0	0	0	0	0.2	0
4653_OG5_180432_7 - FUNGI_YPL241C	YPL241C	"CIN2 - GTPase-activating protein (GAP) for Cin4p; tubulin folding factor C involved in beta-tubulin (Tub2p) folding; mutants display increased chromosome loss and benomyl sensitivity; deletion complemented by human GAP, retinitis pigmentosa 2"	1	0	0	0	0	0	0.2	0
4654_OG5_180433_7 - FUNGI_YDR520C	YDR520C	URC2 - Putative Zn(II)2Cys6 motif containing transcription factor; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; similar to S. kluyveri Urc2p involved in uracil catabolism	1	0	0	0	0	0	0.2	0
4655_OG5_180434_7 - FUNGI_YMR257C	YMR257C	PET111 - Mitochondrial translational activator specific for the COX2 mRNA; located in the mitochondrial inner membrane	1	0	0	0	0	0	0.2	0
4656_OG5_180435_7 - FUNGI_YMR252C	YMR252C	YMR252C - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YMR252C is not an essential gene	1	0	0	0	0	0	0.2	0
4657_OG5_180436_7 - FUNGI_YGL075C	YGL075C	"MPS2 - Essential membrane protein localized at the nuclear envelope and spindle pole body (SPB), required for insertion of the newly duplicated SPB into the nuclear envelope; potentially phosphorylated by Cdc28p"	1	0	0	0	0	0	0.2	0
4658_OG5_180437_7 - FUNGI_YMR163C	YMR163C	INP2 - Peroxisome-specific receptor important for peroxisome inheritance; co-fractionates with peroxisome membranes and co-localizes with peroxisomes in vivo; physically interacts with the myosin V motor Myo2p; INP2 is not an essential gene	1	0	0	0	0	0	0.2	0
4659_OG5_180438_7 - FUNGI_YML011C	YML011C	RAD33 - Protein involved in nucleotide excision repair; green fluorescent protein (GFP)-fusion protein localizes to the nucleus	1	0	0	0	0	0	0.2	0
4660_OG5_180439_7 - FUNGI_YLR381W	YLR381W	CTF3 - Outer kinetochore protein that forms a complex with Mcm16p and Mcm22p; may bind the kinetochore to spindle microtubules	1	0	0	0	0	0	0.2	0
4661_OG5_180440_7 - FUNGI_YLR385C	YLR385C	"SWC7 - Protein of unknown function, component of the Swr1p complex that incorporates Htz1p into chromatin"	1	0	0	0	0	0	0.2	0
4662_OG5_180441_7 - FUNGI_YPL068C	YPL068C	YPL068C - Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and is induced in response to the DNA-damaging agent MMS	1	0	0	0	0	0	0.2	0
4663_OG5_180442_7 - FUNGI_YPL071C	YPL071C	YPL071C - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus	1	0	0	0	0	0	0.2	0
4664_OG5_180443_7 - FUNGI_YPL075W	YPL075W	GCR1 - Transcriptional activator of genes involved in glycolysis; DNA-binding protein that interacts and functions with the transcriptional activator Gcr2p	1	0	0	0	0	0	0.2	0
4665_OG5_180444_7 - FUNGI_YPL099C	YPL099C	"AIM43 - Protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss"	1	0	0	0	0	0	0.2	0
4666_OG5_180445_7 - FUNGI_YIL146C	YIL146C	"ATG32 - Mitochondrial-anchored transmembrane receptor that interacts with the autophagy adaptor protein, Atg11p, and is essential for mitophagy, the selective vacuolar degradation of mitochondria in response to starvation"	1	0	0	0	0	0	0.2	0
4667_OG5_180447_7 - FUNGI_YDR317W	YDR317W	HIM1 - Protein of unknown function involved in DNA repair	1	0	0	0	0	0	0.2	0
4668_OG5_180448_7 - FUNGI_YBR157C	YBR157C	"ICS2 - Protein of unknown function; null mutation does not confer any obvious defects in growth, spore germination, viability, or carbohydrate utilization"	1	0	0	0	0	0	0.2	0
4669_OG5_180450_7 - FUNGI_YPR046W	YPR046W	MCM16 - Protein involved in kinetochore-microtubule mediated chromosome segregation; binds to centromere DNA	1	0	0	0	0	0	0.2	0
4670_OG5_180452_7 - FUNGI_YHR127W	YHR127W	YHR127W - Protein of unknown function; localizes to the nucleus; required for asymmetric localization of Kar9p during mitosis	1	0	0	0	0	0	0.2	0
4671_OG5_180454_7 - FUNGI_YBR045C	YBR045C	"GIP1 - Meiosis-specific regulatory subunit of the Glc7p protein phosphatase, regulates spore wall formation and septin organization, required for expression of some late meiotic genes and for normal localization of Glc7p"	1	0	0	0	0	0	0.2	0
4672_OG5_180455_7 - FUNGI_YDL121C	YDL121C	YDL121C - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDL121C is not an essential protein	1	0	0	0	0	0	0.2	0
4673_OG5_180456_7 - FUNGI_YMR144W	YMR144W	YMR144W - Putative protein of unknown function; localized to the nucleus; YMR144W is not an essential gene	1	0	0	0	0	0	0.2	0
4674_OG5_180457_7 - FUNGI_YHR167W	YHR167W	"THP2 - Subunit of the THO complex, which connects transcription elongation and mitotic recombination, and of the TREX complex, which is recruited to activated genes and couples transcription to mRNA export; involved in telomere maintenance"	1	0	0	0	0	0	0.2	0
4675_OG5_180458_7 - FUNGI_YDL053C	YDL053C	"PBP4 - Pbp1p binding protein, interacts strongly with Pab1p-binding protein 1 (Pbp1p) in the yeast two-hybrid system; also interacts with Lsm12p in a copurification assay"	1	0	0	0	0	0	0.2	0
4676_OG5_180459_7 - FUNGI_YBR044C	YBR044C	TCM62 - Protein involved in the assembly of the mitochondrial succinate dehydrogenase complex; putative chaperone	1	0	0	0	0	0	0.2	0
4677_OG5_180460_7 - FUNGI_YER092W	YER092W	IES5 - Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions	1	0	0	0	0	0	0.2	0
4678_OG5_180461_7 - FUNGI_YNR010W	YNR010W	CSE2 - Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; component of the Med9/10 module; required for regulation of RNA polymerase II activity	1	0	0	0	0	0	0.2	0
4679_OG5_180462_7 - FUNGI_YJL147C	YJL147C	YJL147C - Mitochondrial protein of unknown function; homozygous diploid deletion strain has a sporulation defect characterized by elevated dityrosine in the soluble fraction; expression induced by calcium shortage; YJL147W is a non-essential gene	1	0	0	0	0	0	0.2	0
4680_OG5_180464_7 - FUNGI_YJL149W	YJL149W	DAS1 - Putative SCF ubiquitin ligase F-box protein; interacts physically with both Cdc53p and Skp1 and genetically with CDC34; similar to putative F-box protein YDR131C	1	0	0	0	0	0	0.2	0
4681_OG5_180465_7 - FUNGI_YML091C	YML091C	"RPM2 - Protein subunit of mitochondrial RNase P, has roles in nuclear transcription, cytoplasmic and mitochondrial RNA processing, and mitochondrial translation; distributed to mitochondria, cytoplasmic processing bodies, and the nucleus"	1	0	0	0	0	0	0.2	0
4682_OG5_180466_7 - FUNGI_YER153C	YER153C	"PET122 - Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet494p; located in the mitochondrial inner membrane"	1	0	0	0	0	0	0.2	0
4683_OG5_180467_7 - FUNGI_YER149C	YER149C	"PEA2 - Coiled-coil polarisome protein required for polarized morphogenesis, cell fusion, and low affinity Ca2+ influx; forms polarisome complex with Bni1p, Bud6p, and Spa2p; localizes to sites of polarized growth"	1	0	0	0	0	0	0.2	0
4684_OG5_180468_7 - FUNGI_YER147C	YER147C	"SCC4 - Subunit of cohesin loading factor (Scc2p-Scc4p), a complex required for the loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during double-strand break repair via phosphorylated histone H2AX"	1	0	0	0	0	0	0.2	0
4685_OG5_180469_7 - FUNGI_YGL223C	YGL223C	"COG1 - Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments"	1	0	0	0	0	0	0.2	0
4686_OG5_180470_7 - FUNGI_YOL104C	YOL104C	"NDJ1 - Meiosis-specific telomere protein, required for bouquet formation, effective homolog pairing, ordered cross-over distribution, sister chromatid cohesion at meiotic telomeres, chromosomal segregation and telomere-led rapid prophase movement"	1	0	0	0	0	0	0.2	0
4687_OG5_180471_7 - FUNGI_YOL088C	YOL088C	"MPD2 - Member of the protein disulfide isomerase (PDI) family, exhibits chaperone activity; overexpression suppresses the lethality of a pdi1 deletion but does not complement all Pdi1p functions; undergoes oxidation by Ero1p"	1	0	0	0	0	0	0.2	0
4688_OG5_180472_7 - FUNGI_YGR168C	YGR168C	YGR168C - Putative protein of unknown function; YGR168C is not an essential gene	1	0	0	0	0	0	0.2	0
4689_OG5_180473_7 - FUNGI_YFR023W	YFR023W	"PES4 - Poly(A) binding protein, suppressor of DNA polymerase epsilon mutation, similar to Mip6p"	1	0	0	0	0	0	0.2	0
4690_OG5_180474_7 - FUNGI_YBR258C	YBR258C	"SHG1 - Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres"	1	0	0	0	0	0	0.2	0
4691_OG5_180475_7 - FUNGI_YBR262C	YBR262C	"AIM5 - Protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss"	1	0	0	0	0	0	0.2	0
4692_OG5_180476_7 - FUNGI_YOL053W	YOL053W	AIM39 - Putative protein of unknown function; null mutant displays elevated frequency of mitochondrial genome loss	1	0	0	0	0	0	0.2	0
4693_OG5_180477_7 - FUNGI_YGR142W	YGR142W	"BTN2 - v-SNARE binding protein that facilitates specific protein retrieval from a late endosome to the Golgi; modulates arginine uptake, possible role in mediating pH homeostasis between the vacuole and plasma membrane H(+)-ATPase"	1	0	0	0	0	0	0.2	0
4694_OG5_180478_7 - FUNGI_YGR140W	YGR140W	"CBF2 - Essential kinetochore protein, component of the CBF3 multisubunit complex that binds to the CDEIII region of the centromere; Cbf2p also binds to the CDEII region possibly forming a different multimeric complex, ubiquitinated in vivo"	1	0	0	0	0	0	0.2	0
4695_OG5_180479_7 - FUNGI_YGR122W	YGR122W	"YGR122W - Probable ortholog of A. nidulans PalC, which is involved in pH regulation and binds to the ESCRT-III complex; null mutant does not properly process Rim101p and has decreased resistance to rapamycin; GFP-fusion protein is cytoplasmic"	1	0	0	0	0	0	0.2	0
4696_OG5_180480_7 - FUNGI_YBR165W	YBR165W	UBS1 - Ubiquitin-conjugating enzyme suppressor that functions as a general positive regulator of Cdc34p activity; nuclear protein that may represent a link between nucleocytoplasmic transport and ubiquitin ligase activity	1	0	0	0	0	0	0.2	0
4697_OG5_180483_7 - FUNGI_YKL112W	YKL112W	"ABF1 - DNA binding protein with possible chromatin-reorganizing activity involved in transcriptional activation, gene silencing, and DNA replication and repair"	1	0	0	0	0	0	0.2	0
4698_OG5_180484_7 - FUNGI_YMR094W	YMR094W	"CTF13 - Subunit of the CBF3 complex, which binds to the CDE III element of centromeres, bending the DNA upon binding, and may be involved in sister chromatid cohesion during mitosis"	1	0	0	0	0	0	0.2	0
4699_OG5_180486_7 - FUNGI_YER077C	YER077C	YER077C - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; null mutation results in a decrease in plasma membrane electron transport	1	0	0	0	0	0	0.2	0
4700_OG5_180487_7 - FUNGI_YCR069W	YCR069W	"CPR4 - Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; has a potential role in the secretory pathway"	1	0	0	0	0	0	0.2	0
4701_OG5_180488_7 - FUNGI_YNL159C	YNL159C	ASI2 - Integral inner nuclear membrane protein that acts with Asi1p and Asi3p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals	1	0	0	0	0	0	0.2	0
4702_OG5_180489_7 - FUNGI_YNL158W	YNL158W	"PGA1 - Essential component of GPI-mannosyltransferase II, responsible for second mannose addition to GPI precursors as a partner of Gpi18p; required for maturation of Gas1p and Pho8p; has synthetic genetic interations with secretory pathway genes"	1	0	0	0	0	0	0.2	0
4703_OG5_180490_7 - FUNGI_YNL164C	YNL164C	"IBD2 - Component of the BUB2-dependent spindle checkpoint pathway, interacts with Bfa1p and functions upstream of Bub2p and Bfa1p"	1	0	0	0	0	0	0.2	0
4704_OG5_180491_7 - FUNGI_YNL165W	YNL165W	YNL165W - Putative protein of unknown function; YNL165W is not an essential gene	1	0	0	0	0	0	0.2	0
4705_OG5_180492_7 - FUNGI_YDL176W	YDL176W	"YDL176W - Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene"	1	0	0	0	0	0	0.2	0
4706_OG5_180493_7 - FUNGI_YDL180W	YDL180W	YDL180W - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole	1	0	0	0	0	0	0.2	0
4707_OG5_180494_7 - FUNGI_YML112W	YML112W	"CTK3 - Gamma subunit of C-terminal domain kinase I (CTDK-I), which phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and ribosomal protein Rps2p to increase translational fidelity"	1	0	0	0	0	0	0.2	0
4708_OG5_180495_7 - FUNGI_YPL124W	YPL124W	"SPC29 - Inner plaque spindle pole body (SPB) component, links the central plaque component Spc42p to the inner plaque component Spc110p; required for SPB duplication"	1	0	0	0	0	0	0.2	0
4709_OG5_180498_7 - FUNGI_YDL186W	YDL186W	YDL186W - Putative protein of unknown function; YDL186W is not an essential gene	1	0	0	0	0	0	0.2	0
4710_OG5_180499_7 - FUNGI_YDL129W	YDL129W	YDL129W - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; YDL129W is not an essential gene	1	0	0	0	0	0	0.2	0
4711_OG5_180501_7 - FUNGI_YNL076W	YNL076W	MKS1 - Pleiotropic negative transcriptional regulator involved in Ras-CAMP and lysine biosynthetic pathways and nitrogen regulation; involved in retrograde (RTG) mitochondria-to-nucleus signaling	1	0	0	0	0	0	0.2	0
4712_OG5_180502_7 - FUNGI_YNL077W	YNL077W	"APJ1 - Putative chaperone of the HSP40 (DNAJ) family; overexpression interferes with propagation of the [Psi+] prion; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"	1	0	0	0	0	0	0.2	0
4713_OG5_180503_7 - FUNGI_YNL078W	YNL078W	NIS1 - Protein localized in the bud neck at G2/M phase; physically interacts with septins; possibly involved in a mitotic signaling network	1	0	0	0	0	0	0.2	0
4714_OG5_180504_7 - FUNGI_YDR439W	YDR439W	"LRS4 - Nucleolar protein that forms a complex with Csm1p, and then Mam1p at kinetochores during meiosis I to mediate accurate homolog segregation; required for condensin recruitment to the replication fork barrier site and rDNA repeat segregation"	1	0	0	0	0	0	0.2	0
4715_OG5_180505_7 - FUNGI_YDR309C	YDR309C	"GIC2 - Redundant rho-like GTPase Cdc42p effector; homolog of Gic1p; involved in initiation of budding and cellular polarization; interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain and with PI(4,5)P2 via a polybasic region"	1	0	0	0	0	0	0.2	0
4716_OG5_180506_7 - FUNGI_YDR307W	YDR307W	YDR307W - Putative protein of unknown function	1	0	0	0	0	0	0.2	0
4717_OG5_180507_7 - FUNGI_YNL180C	YNL180C	"RHO5 - Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely involved in protein kinase C (Pkc1p)-dependent signal transduction pathway that controls cell integrity"	1	0	0	0	0	0	0.2	0
4718_OG5_180509_7 - FUNGI_YKL214C	YKL214C	"YRA2 - Member of the REF (RNA and export factor binding proteins) family; when overexpressed, can substitute for the function of Yra1p in export of poly(A)+ mRNA from the nucleus"	1	0	0	0	0	0	0.2	0
4719_OG5_180510_7 - FUNGI_YJL192C	YJL192C	"SOP4 - ER-membrane protein; suppressor of pma1-7, deletion of SOP4 slows down the export of wild-type Pma1p and Pma1-7 from the ER"	1	0	0	0	0	0	0.2	0
4720_OG5_180511_7 - FUNGI_YGR206W	YGR206W	"MVB12 - ESCRT-I subunit required to stabilize oligomers of the ESCRT-I core complex (Stp22p, Vps28p, Srn2p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; deletion mutant is sensitive to rapamycin and nystatin"	1	0	0	0	0	0	0.2	0
4721_OG5_180512_7 - FUNGI_YGR084C	YGR084C	MRP13 - Mitochondrial ribosomal protein of the small subunit	1	0	0	0	0	0	0.2	0
4722_OG5_180513_7 - FUNGI_YGR079W	YGR079W	YGR079W - Putative protein of unknown function; YGR079W is not an essential gene	1	0	0	0	0	0	0.2	0
4723_OG5_180514_7 - FUNGI_YGR077C	YGR077C	"PEX8 - Intraperoxisomal organizer of the peroxisomal import machinery, tightly associated with the lumenal face of the peroxisomal membrane, essential for peroxisome biogenesis, binds PTS1-signal receptor Pex5p"	1	0	0	0	0	0	0.2	0
4724_OG5_180515_7 - FUNGI_YDL044C	YDL044C	MTF2 - Mitochondrial matrix protein that interacts with an N-terminal region of mitochondrial RNA polymerase (Rpo41p) and couples RNA processing and translation to transcription	1	0	0	0	0	0	0.2	0
4725_OG5_180516_7 - FUNGI_YDL013W	YDL013W	"SLX5 - Subunit of the Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex, stimulated by SUMO-modified substrates; contains a RING domain and two SIMs (SUMO-interacting motifs); forms SUMO-dependent nuclear foci, including DNA repair centers"	1	0	0	0	0	0	0.2	0
4726_OG5_180517_7 - FUNGI_YER123W	YER123W	"YCK3 - Palmitoylated, vacuolar membrane-localized casein kinase I isoform; negatively regulates vacuole fusion during hypertonic stress via phosphorylation of Vps41p; shares essential functions with Hrr25p; regulates vesicle fusion in AP-3 pathway"	1	0	0	0	0	0	0.2	0
4727_OG5_180518_7 - FUNGI_YHL006C	YHL006C	"SHU1 - Protein involved in a Rad51p-, Rad54p-dependent pathway for homologous recombination repair, important for error-free repair of spontaneous and induced DNA lesions to protect the genome from mutation; associates with Shu2p, Psy3p, and Csm2p"	1	0	0	0	0	0	0.2	0
4728_OG5_180519_7 - FUNGI_YMR122W-A	YMR122W-A	YMR122W-A - Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and endoplasmic reticulum	1	0	0	0	0	0	0.2	0
4729_OG5_180520_7 - FUNGI_YMR133W	YMR133W	REC114 - Protein involved in early stages of meiotic recombination; possibly involved in the coordination of recombination and meiotic division; mutations lead to premature initiation of the first meiotic division	1	0	0	0	0	0	0.2	0
4730_OG5_180521_7 - FUNGI_YGR052W	YGR052W	"FMP48 - Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; induced by treatment with 8-methoxypsoralen and UVA irradiation"	1	0	0	0	0	0	0.2	0
4731_OG5_180522_7 - FUNGI_YGR067C	YGR067C	YGR067C - Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p	1	0	0	0	0	0	0.2	0
4732_OG5_180523_7 - FUNGI_YNL214W	YNL214W	PEX17 - Peroxisomal membrane peroxin and subunit of the docking complex that facilitates the import of peroxisomal matrix proteins; required for peroxisome biogenesis	1	0	0	0	0	0	0.2	0
4733_OG5_180524_7 - FUNGI_YOR083W	YOR083W	"WHI5 - Repressor of G1 transcription that binds to SCB binding factor (SBF) at SCB target promoters in early G1; phosphorylation of Whi5p by the CDK, Cln3p/Cdc28p relieves repression and promoter binding by Whi5; periodically expressed in G1"	1	0	0	0	0	0	0.2	0
4734_OG5_180525_7 - FUNGI_YLR263W	YLR263W	"RED1 - Protein component of the synaptonemal complex axial elements, involved in chromosome segregation during the first meiotic division; critical for coupling checkpoint signaling to SC formation; interacts with Hop1p, Mec3p and Ddc1p"	1	0	0	0	0	0	0.2	0
4735_OG5_180527_7 - FUNGI_YBR211C	YBR211C	"AME1 - Essential kinetochore protein associated with microtubules and spindle pole bodies; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p); involved in spindle checkpoint maintenance"	1	0	0	0	0	0	0.2	0
4736_OG5_180528_7 - FUNGI_YBR225W	YBR225W	YBR225W - Putative protein of unknown function; non-essential gene identified in a screen for mutants affected in mannosylphophorylation of cell wall components	1	0	0	0	0	0	0.2	0
4737_OG5_180529_7 - FUNGI_YML006C	YML006C	"GIS4 - CAAX box containing protein of unknown function, proposed to be involved in the RAS/cAMP signaling pathway"	1	0	0	0	0	0	0.2	0
4738_OG5_180530_7 - FUNGI_YKL130C	YKL130C	SHE2 - RNA-binding protein that binds specific mRNAs and interacts with She3p; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud	1	0	0	0	0	0	0.2	0
4739_OG5_180531_7 - FUNGI_YKR067W	YKR067W	GPT2 - Glycerol-3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase located in lipid particles and the ER; involved in the stepwise acylation of glycerol-3-phosphate and dihydroxyacetone in lipid biosynthesis	1	0	0	0	0	0	0.2	0
4740_OG5_180532_7 - FUNGI_YKL109W	YKL109W	"HAP4 - Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex"	1	0	0	0	0	0	0.2	0
4741_OG5_180533_7 - FUNGI_YIR014W	YIR014W	YIR014W - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p; YIR014W is a non-essential gene	1	0	0	0	0	0	0.2	0
4742_OG5_180534_7 - FUNGI_YOR255W	YOR255W	OSW1 - Protein involved in sporulation; required for the construction of the outer spore wall layers; required for proper localization of Spo14p	1	0	0	0	0	0	0.2	0
4743_OG5_180535_7 - FUNGI_YOR147W	YOR147W	"MDM32 - Mitochondrial inner membrane protein with similarity to Mdm31p, required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MDM10, MDM12, and MDM34"	1	0	0	0	0	0	0.2	0
4744_OG5_180536_7 - FUNGI_YNL133C	YNL133C	"FYV6 - Protein of unknown function, required for survival upon exposure to K1 killer toxin; proposed to regulate double-strand break repair via non-homologous end-joining"	1	0	0	0	0	0	0.2	0
4745_OG5_180537_7 - FUNGI_YDR078C	YDR078C	"SHU2 - Protein involved in a Rad51p-, Rad54p-dependent pathway for homologous recombination repair, important for error-free repair of spontaneous and induced DNA lesions to protect the genome from mutation; associates with Shu1p, Psy3p, and Csm2p"	1	0	0	0	0	0	0.2	0
4746_OG5_180538_7 - FUNGI_YML129C	YML129C	"COX14 - Mitochondrial membrane protein, involved in translational regulation of Cox1p and assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes"	1	0	0	0	0	0	0.2	0
4747_OG5_180539_7 - FUNGI_YDR239C	YDR239C	"YDR239C - Protein of unknown function that may interact with ribosomes, based on co-purification experiments"	1	0	0	0	0	0	0.2	0
4748_OG5_180540_7 - FUNGI_YDR240C	YDR240C	"SNU56 - Component of U1 snRNP required for mRNA splicing via spliceosome; yeast specific, no metazoan counterpart; interacts with mRNA in commitment complex"	1	0	0	0	0	0	0.2	0
4749_OG5_180541_7 - FUNGI_YDR249C	YDR249C	YDR249C - Putative protein of unknown function	1	0	0	0	0	0	0.2	0
4750_OG5_180542_7 - FUNGI_YDR022C	YDR022C	CIS1 - Autophagy-specific protein required for autophagosome formation; may form a complex with Atg17p and Atg29p that localizes other proteins to the pre-autophagosomal structure; high-copy suppressor of CIK1 deletion	1	0	0	0	0	0	0.2	0
4751_OG5_180544_7 - FUNGI_YFL049W	YFL049W	SWP82 - Member of the SWI/SNF chromatin remodeling complex in which it plays an as yet unidentified role; has identifiable counterparts in closely related yeast species; abundantly expressed in many growth conditions; paralog of Npl6p	1	0	0	0	0	0	0.2	0
4752_OG5_180545_7 - FUNGI_YMR187C	YMR187C	YMR187C - Putative protein of unknown function; YMR187C is not an essential gene	1	0	0	0	0	0	0.2	0
4753_OG5_180546_7 - FUNGI_YMR184W	YMR184W	ADD37 - Protein of unknown function involved in ER-associated protein degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YMR184W is not an essential gene	1	0	0	0	0	0	0.2	0
4754_OG5_180547_7 - FUNGI_YEL005C	YEL005C	"VAB2 - Protein with a potential role in vacuolar function, as suggested by its ability to bind Vac8p; likely member of BLOC complex involved in endosomal cargo sorting; Vab2p-GFP-fusion localizes to cytoplasm in punctate patter"	1	0	0	0	0	0	0.2	0
4755_OG5_180548_7 - FUNGI_YIL161W	YIL161W	YIL161W - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; mRNA is enriched in Scp160p-associated mRNPs; YIL161W is a non-essential gene	1	0	0	0	0	0	0.2	0
4756_OG5_180549_7 - FUNGI_YOR213C	YOR213C	"SAS5 - Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which  acetylates free histones and nucleosomes and regulates transcriptional silencing; stimulates Sas2p HAT activity"	1	0	0	0	0	0	0.2	0
4757_OG5_180550_7 - FUNGI_YKR037C	YKR037C	"SPC34 - Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; also localized to nuclear side of spindle pole body"	1	0	0	0	0	0	0.2	0
4758_OG5_180551_7 - FUNGI_YJL089W	YJL089W	SIP4 - C6 zinc cluster transcriptional activator that binds to the carbon source-responsive element (CSRE) of gluconeogenic genes; involved in the positive regulation of gluconeogenesis; regulated by Snf1p protein kinase; localized to the nucleus	1	0	0	0	0	0	0.2	0
4759_OG5_180552_7 - FUNGI_YMR052W	YMR052W	"FAR3 - Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far7p, Far8p, Far9p, Far10p, and Far11p; localizes to the endoplasmic reticulum"	1	0	0	0	0	0	0.2	0
4760_OG5_180553_7 - FUNGI_YKL075C	YKL075C	YKL075C - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; proposed to be involved in resistance to streptozotocin and camptothecin	1	0	0	0	0	0	0.2	0
4761_OG5_180554_7 - FUNGI_YGL175C	YGL175C	SAE2 - Endonuclease that processes hairpin DNA structures with the MRX complex; involved in meiotic and mitotic double-strand break repair; phosphorylated in response to DNA damage and required for normal resistance to DNA-damaging agents	1	0	0	0	0	0	0.2	0
4762_OG5_180555_7 - FUNGI_YBR085C-A	YBR085C-A	YBR085C-A - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus	1	0	0	0	0	0	0.2	0
4763_OG5_180557_7 - FUNGI_YPR151C	YPR151C	SUE1 - Mitochondrial protein required for degradation of unstable forms of cytochrome c	1	0	0	0	0	0	0.2	0
4764_OG5_180558_7 - FUNGI_YPR148C	YPR148C	"YPR148C - Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern"	1	0	0	0	0	0	0.2	0
4765_OG5_180559_7 - FUNGI_YOR066W	YOR066W	"MSA1 - Activator of G1-specific transcription factors, MBF and SBF; involved in regulation of the timing of G1-specific gene transcription and cell cycle initiation; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation"	1	0	0	0	0	0	0.2	0
4766_OG5_180560_7 - FUNGI_YOR279C	YOR279C	RFM1 - DNA-binding protein required for vegetative repression of middle sporulation genes; specificity factor that directs the Hst1p histone deacetylase to some of the promoters regulated by Sum1p; involved in telomere maintenance	1	0	0	0	0	0	0.2	0
4767_OG5_180561_7 - FUNGI_YML062C	YML062C	"MFT1 - Subunit of the THO complex, which is a nuclear complex comprised of Hpr1p, Mft1p, Rlr1p, and Thp2p, that is involved in transcription elongation and mitotic recombination; involved in telomere maintenance"	1	0	0	0	0	0	0.2	0
4768_OG5_180563_7 - FUNGI_YER167W	YER167W	"BCK2 - Protein rich in serine and threonine residues involved in protein kinase C signaling pathway, which controls cell integrity; overproduction suppresses pkc1 mutations"	1	0	0	0	0	0	0.2	0
4769_OG5_180564_7 - FUNGI_YER180C	YER180C	"ISC10 - Protein required for sporulation, transcript is induced 7.5 hours after induction of meiosis, expected to play significant role in the formation of reproductive cells"	1	0	0	0	0	0	0.2	0
4770_OG5_180565_7 - FUNGI_YDR113C	YDR113C	"PDS1 - Securin, inhibits anaphase by binding separin Esp1p; blocks cyclin destruction and mitotic exit, essential for meiotic progression and mitotic cell cycle arrest; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation"	1	0	0	0	0	0	0.2	0
4771_OG5_180566_7 - FUNGI_YLR079W	YLR079W	"SIC1 - Inhibitor of Cdc28-Clb kinase complexes that controls G1/S phase transition, preventing premature S phase and ensuring genomic integrity; phosphorylation targets Sic1p for SCF(CDC4)-dependent turnover; functional homolog of mammalian Kip1"	1	0	0	0	0	0	0.2	0
4772_OG5_180567_7 - FUNGI_YJR135C	YJR135C	MCM22 - Protein involved in minichromosome maintenance; component of the kinetochore; binds to centromeric DNA in a Ctf19p-dependent manner	1	0	0	0	0	0	0.2	0
4773_OG5_180568_7 - FUNGI_YBR077C	YBR077C	"SLM4 - Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; gene exhibits synthetic genetic interaction with MSS4"	1	0	0	0	0	0	0.2	0
4774_OG5_180569_7 - FUNGI_YPL161C	YPL161C	BEM4 - Protein involved in establishment of cell polarity and bud emergence; interacts with the Rho1p small GTP-binding protein and with the Rho-type GTPase Cdc42p; involved in maintenance of proper telomere length	1	0	0	0	0	0	0.2	0
4775_OG5_180570_7 - FUNGI_YPL158C	YPL158C	AIM44 - Protein of unknown function; GFP-fusion protein localizes to the bud neck; transcription is regulated by Swi5p; null mutant displays elevated frequency of mitochondrial genome loss	1	0	0	0	0	0	0.2	0
4776_OG5_180571_7 - FUNGI_YPL156C	YPL156C	PRM4 - Pheromone-regulated protein proposed to be involved in mating; predicted to have 1 transmembrane segment; transcriptionally regulated by Ste12p during mating and by Cat8p during the diauxic shift	1	0	0	0	0	0	0.2	0
4777_OG5_180572_7 - FUNGI_YEL018W	YEL018W	"EAF5 - Esa1p-associated factor, non-essential subunit of the NuA4 acetyltransferase complex"	1	0	0	0	0	0	0.2	0
4778_OG5_180573_7 - FUNGI_YNL304W	YNL304W	YPT11 - Rab family GTPase that interacts with the C-terminal tail domain of Myo2p; mediates distribution of mitochondria and endoplasmic reticuli to daughter cells	1	0	0	0	0	0	0.2	0
4779_OG5_180574_7 - FUNGI_YNL311C	YNL311C	"SKP2 - F-box protein of unknown function predicted to be part of an SCF ubiquitin protease complex; involved in regulating protein levels of sulfur metabolism enzymes; may interact with ribosomes, based on co-purification experiments"	1	0	0	0	0	0	0.2	0
4780_OG5_180576_7 - FUNGI_YNL314W	YNL314W	"DAL82 - Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain"	1	0	0	0	0	0	0.2	0
4781_OG5_180578_7 - FUNGI_YKR064W	YKR064W	"OAF3 - Zinc cluster protein; regulates transcription in response to oleate levels; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"	1	0	0	0	0	0	0.2	0
4782_OG5_180579_7 - FUNGI_YKR049C	YKR049C	"FMP46 - Putative redox protein containing a thioredoxin fold; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"	1	0	0	0	0	0	0.2	0
4783_OG5_180580_7 - FUNGI_YKR046C	YKR046C	PET10 - Protein of unknown function that co-purifies with lipid particles; expression pattern suggests a role in respiratory growth; computational analysis of large-scale protein-protein interaction data suggests a role in ATP/ADP exchange	1	0	0	0	0	0	0.2	0
4784_OG5_180581_7 - FUNGI_YBR168W	YBR168W	"PEX32 - Peroxisomal integral membrane protein, involved in negative regulation of peroxisome size; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p"	1	0	0	0	0	0	0.2	0
4785_OG5_180582_7 - FUNGI_YPL052W	YPL052W	"OAZ1 - Regulator of ornithine decarboxylase (Spe1p), antizyme that binds to Spe1p to regulate ubiquitin-independent degradation; ribosomal frameshifting during synthesis of Oaz1p and its ubiquitin-mediated degradation are both polyamine-regulated"	1	0	0	0	0	0	0.2	0
4786_OG5_180583_7 - FUNGI_YJR021C	YJR021C	REC107 - Protein involved in early stages of meiotic recombination; involved in coordination between the initiation of recombination and the first division of meiosis; part of a complex (Rec107p-Mei4p-Rec114p) required for ds break formation	1	0	0	0	0	0	0.2	0
4787_OG5_180584_7 - FUNGI_YJR022W	YJR022W	"LSM8 - Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) that is part of spliceosomal U6 snRNP and is also implicated in processing of pre-tRNA, pre-snoRNA, and pre-rRNA"	1	0	0	0	0	0	0.2	0
4788_OG5_180585_7 - FUNGI_YJR030C	YJR030C	YJR030C - Putative protein of unknown function; expression repressed in carbon limited vs carbon replete chemostat cultures; YJR030C is a non-essential gene	1	0	0	0	0	0	0.2	0
4789_OG5_180586_7 - FUNGI_YJL165C	YJL165C	"HAL5 - Putative protein kinase; overexpression increases sodium and lithium tolerance, whereas gene disruption increases cation and low pH sensitivity and impairs potassium uptake, suggesting a role in regulation of Trk1p and/or Trk2p transporters"	1	0	0	0	0	0	0.2	0
4790_OG5_180587_7 - FUNGI_YMR160W	YMR160W	YMR160W - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of the vacuole; mutant has enhanced sensitivity to overexpression of mutant huntingtin; YMR160W is not an essential gene	1	0	0	0	0	0	0.2	0
4791_OG5_180588_7 - FUNGI_YLR408C	YLR408C	BLS1 - Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome; YLR408C is not an essential gene	1	0	0	0	0	0	0.2	0
4792_OG5_180589_7 - FUNGI_YLR404W	YLR404W	"FLD1 - Seipin protein involved in lipid droplet morphology, number, and size; proposed to be involved in lipid metabolism; related to the human BSCL2 which is associated with lipodystrophy"	1	0	0	0	0	0	0.2	0
4793_OG5_180590_7 - FUNGI_YAL031C	YAL031C	GIP4 - Cytoplasmic Glc7-interacting protein whose overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; potential Cdc28p substrate	1	0	0	0	0	0	0.2	0
4794_OG5_180591_7 - FUNGI_YIL055C	YIL055C	YIL055C - Putative protein of unknown function	1	0	0	0	0	0	0.2	0
4795_OG5_180592_7 - FUNGI_YIL071C	YIL071C	"PCI8 - Possible shared subunit of Cop9 signalosome (CSN) and eIF3, binds eIF3b subunit Prt1p, has possible dual functions in transcriptional and translational control, contains a PCI (Proteasome-COP9 signalosome (CSN)-eIF3) domain"	1	0	0	0	0	0	0.2	0
4796_OG5_180593_7 - FUNGI_YIL077C	YIL077C	"YIL077C - Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)"	1	0	0	0	0	0	0.2	0
4797_OG5_180595_7 - FUNGI_YKL048C	YKL048C	"ELM1 - Serine/threonine protein kinase that regulates cellular morphogenesis, septin behavior, and cytokinesis; required for the regulation of other kinases; forms part of the bud neck ring"	1	0	0	0	0	0	0.2	0
4798_OG5_180596_7 - FUNGI_YKL063C	YKL063C	YKL063C - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi	1	0	0	0	0	0	0.2	0
4799_OG5_180597_7 - FUNGI_YHR184W	YHR184W	SSP1 - Protein involved in the control of meiotic nuclear division and coordination of meiosis with spore formation; transcription is induced midway through meiosis	1	0	0	0	0	0	0.2	0
4800_OG5_180598_7 - FUNGI_YMR298W	YMR298W	"LIP1 - Ceramide synthase subunit; single-span ER membrane protein associated with Lag1p and Lac1p and required for ceramide synthase activity, null mutant grows extremely slowly and is defective in ceramide synthesis"	1	0	0	0	0	0	0.2	0
4801_OG5_180599_7 - FUNGI_YMR299C	YMR299C	"DYN3 - Dynein light intermediate chain (LIC); localizes with dynein, null mutant is defective in nuclear migration"	1	0	0	0	0	0	0.2	0
4802_OG5_181856_7 - FUNGI_YPR133W-A	YPR133W-A	TOM5 - Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import of all mitochondrially directed proteins; involved in transfer of precursors from the Tom70p and Tom20p receptors to the Tom40p pore	1	0	0	0	0	0	0.2	0
4803_OG5_147213_7 - FUNGI_YLR093C	YLR093C	NYV1 - v-SNARE component of the vacuolar SNARE complex involved in vesicle fusion; inhibits ATP-dependent Ca(2+) transport activity of Pmc1p in the vacuolar membrane	1	0	0	0.125	0.047619048	0	0.2	0.0625
4804_OG5_156903_7 - FUNGI_Q0065	Q0065	"AI4 - Endonuclease I-SceII, encoded by a mobile group I intron within the mitochondrial COX1 gene; intron is normally spliced by the BI4p maturase but AI4p can mutate to acquire the same maturase activity"	1	0	0	0.125	0.047619048	0	0.2	0.0625
4805_OG5_153050_7 - FUNGI_YPR013C	YPR013C	YPR013C - Putative zinc finger protein; YPR013C is not an essential gene	1	0	0	0	0.047619048	0.071428571	0.2	0
4806_OG5_153050_7 - FUNGI_YPR015C	YPR015C	YPR015C - Putative protein of unknown function; overexpression causes a cell cycle delay or arrest	1	0	0	0	0.047619048	0.071428571	0.2	0
4807_OG5_153046_7 - FUNGI_YKL107W	YKL107W	YKL107W - Putative protein of unknown function; proposed to be a palmitoylated membrane protein	1	0	0.027777778	0.125	0	0	0.2	0
4808_OG5_164999_7 - FUNGI_YJL162C	YJL162C	"JJJ2 - Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein"	1	0	0	0.125	0	0	0.2	0.0625
4809_OG5_168540_7 - FUNGI_YCR060W	YCR060W	"TAH1 - HSP90 cofactor; interacts with Hsp82p, Pih1p, Rvb1 and Rvb2, contains a single TPR domain with at least two TPR motifs"	1	0	0	0.125	0	0	0.2	0
4810_OG5_170020_7 - FUNGI_YPR120C	YPR120C	CLB5 - B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 phase	1	0	0	0.125	0	0	0.2	0
4811_OG5_170080_7 - FUNGI_YPR114W	YPR114W	YPR114W - Putative protein of unknown function	1	0	0	0.125	0	0	0.2	0
4812_OG5_171927_7 - FUNGI_YDR186C	YDR186C	"YDR186C - Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm"	1	0	0	0.125	0	0	0.2	0
4813_OG5_171941_7 - FUNGI_YDR310C	YDR310C	"SUM1 - Transcriptional repressor required for mitotic repression of middle sporulation-specific genes; also acts as general replication initiation factor; involved in telomere maintenance, chromatin silencing; regulated by pachytene checkpoint"	1	0	0	0.125	0	0	0.2	0
4814_OG5_133076_7 - FUNGI_YDR077W	YDR077W	"SED1 - Major stress-induced structural GPI-cell wall glycoprotein in stationary-phase cells, associates with translating ribosomes, possible role in mitochondrial genome maintenance; ORF contains two distinct variable minisatellites"	1	0	0	0.125	0.142857143	0	0.15	0.125
4815_OG5_163373_7 - FUNGI_YCL028W	YCL028W	"RNQ1 - [PIN(+)] prion, an infectious protein conformation that is generally an ordered protein aggregate"	1	0	0	0	0.142857143	0	0.15	0
4816_OG5_155185_7 - FUNGI_YMR164C	YMR164C	MSS11 - Transcription factor involved in regulation of invasive growth and starch degradation; controls the activation of MUC1 and STA2 in response to nutritional signals	1	0	0	0.125	0.047619048	0	0.15	0.0625
4817_OG5_158751_7 - FUNGI_YKL032C	YKL032C	"IXR1 - Protein that binds DNA containing intrastrand cross-links formed by cisplatin, contains two HMG (high mobility group box) domains, which confer the ability to bend cisplatin-modified DNA; mediates aerobic transcriptional repression of COX5b"	1	0	0	0	0.047619048	0.071428571	0.15	0.0625
4818_OG5_180420_7 - FUNGI_YAL028W	YAL028W	"FRT2 - Tail-anchored ER membrane protein, interacts with homolog Frt1p; promotes growth in conditions of high Na+, alkaline pH, or cell wall stress, possibly via a role in posttranslational translocation; potential Cdc28p substrate"	1	0	0	0	0.047619048	0	0.15	0
4819_OG5_180451_7 - FUNGI_YGL134W	YGL134W	"PCL10 - Pho85p cyclin; recruits, activates, and targets Pho85p cyclin-dependent protein kinase to its substrate"	1	0	0	0	0.047619048	0	0.15	0
4820_OG5_182507_7 - FUNGI_YKR022C	YKR022C	"NTR2 - Essential protein that forms a dimer with Ntr1p; also forms a trimer, with Ntr2p and the DExD/H-box RNA helicase Prp43p, that is involved in spliceosome disassembly"	1	0	0	0	0.047619048	0	0.15	0
4821_OG5_165431_7 - FUNGI_YPL245W	YPL245W	YPL245W - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm	1	0.125	0.027777778	0	0	0	0.15	0
4822_OG5_171209_7 - FUNGI_YDR285W	YDR285W	ZIP1 - Transverse filament protein of the synaptonemal complex; required for normal levels of meiotic recombination and pairing between homologous chromosome during meiosis; potential Cdc28p substrate	1	0	0.027777778	0.125	0	0	0.15	0
4823_OG5_155113_7 - FUNGI_YOR028C	YOR028C	CIN5 - Basic leucine zipper (bZIP) transcription factor of the yAP-1 family; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; mediates pleiotropic drug resistance and salt tolerance; nuclearly localized under oxidative stress and sequestered in the cytoplasm by Lot6p under reducing conditions	1	0	0.027777778	0	0	0	0.15	0.0625
4824_OG5_175349_7 - FUNGI_YPL274W	YPL274W	"SAM3 - High-affinity S-adenosylmethionine permease, required for utilization of S-adenosylmethionine as a sulfur source; has similarity to S-methylmethionine permease Mmp1p"	1	0	0	0	0	0	0.15	0
4825_OG5_175349_7 - FUNGI_YLL061W	YLL061W	"MMP1 - High-affinity S-methylmethionine permease, required for utilization of S-methylmethionine as a sulfur source; has similarity to S-adenosylmethionine permease Sam3p"	1	0	0	0	0	0	0.15	0
4826_OG5_179779_7 - FUNGI_YOR377W	YOR377W	ATF1 - Alcohol acetyltransferase with potential roles in lipid and sterol metabolism; responsible for the major part of volatile acetate ester production during fermentation	1	0	0	0	0	0	0.15	0
4827_OG5_180364_7 - FUNGI_YLL054C	YLL054C	"YLL054C - Putative protein of unknown function with similarity to Pip2p, an oleate-specific transcriptional activator of peroxisome proliferation; YLL054C is not an essential gene"	1	0	0	0	0	0	0.15	0
4828_OG5_180364_7 - FUNGI_YCR106W	YCR106W	RDS1 - Zinc cluster transcription factor involved in conferring resistance to cycloheximide	1	0	0	0	0	0	0.15	0
4829_OG5_182506_7 - FUNGI_YBR250W	YBR250W	SPO23 - Protein of unknown function; associates with meiosis-specific protein Spo1p	1	0	0	0	0	0	0.15	0
4830_OG5_182510_7 - FUNGI_YER187W	YER187W	YER187W - Putative protein of unknown function; induced in respiratory-deficient cells	1	0	0	0	0	0	0.15	0
4831_OG5_182510_7 - FUNGI_YGL262W	YGL262W	YGL262W - Putative protein of unknown function; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein; YGL262W is not an essential gene	1	0	0	0	0	0	0.15	0
4832_OG5_182952_7 - FUNGI_YOR382W	YOR382W	"FIT2 - Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall"	1	0	0	0	0	0	0.15	0
4833_OG5_186829_7 - FUNGI_YKR044W	YKR044W	"UIP5 - Protein of unknown function that interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates"	1	0	0	0	0	0	0.15	0
4834_OG5_188102_7 - FUNGI_YOR380W	YOR380W	RDR1 - Transcriptional repressor involved in the control of multidrug resistance; negatively regulates expression of the PDR5 gene; member of the Gal4p family of zinc cluster proteins	1	0	0	0	0	0	0.15	0
4835_OG5_188452_7 - FUNGI_YGL185C	YGL185C	YGL185C - Putative protein with sequence similarity to hydroxyacid dehydrogenases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	1	0	0	0	0	0	0.15	0
4836_OG5_188647_7 - FUNGI_YPL061W	YPL061W	"ALD6 - Cytosolic aldehyde dehydrogenase, activated by Mg2+ and utilizes NADP+ as the preferred coenzyme; required for conversion of acetaldehyde to acetate; constitutively expressed; locates to the mitochondrial outer surface upon oxidative stress"	1	0	0	0	0	0	0.15	0
4837_OG5_188890_7 - FUNGI_YOL007C	YOL007C	CSI2 - Protein of unknown function; green fluorescent protein (GFP)- fusion protein localizes to the mother side of the bud neck and the vacuole; YOL007C is not an essential gene	1	0	0	0	0	0	0.15	0
4838_OG5_191482_7 - FUNGI_YDR506C	YDR506C	YDR506C - Possible membrane-localized protein	1	0	0	0	0	0	0.15	0
4839_OG5_193612_7 - FUNGI_YPL014W	YPL014W	YPL014W - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus	1	0	0	0	0	0	0.15	0
4840_OG5_193623_7 - FUNGI_YJR089W	YJR089W	"BIR1 - Subunit of chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), which regulates chromosome segregation; required for chromosome bi-orientation and for spindle assembly checkpoint activation upon reduced sister kinetochore tension"	1	0	0	0	0	0	0.15	0
4841_OG5_193652_7 - FUNGI_YGR177C	YGR177C	"ATF2 - Alcohol acetyltransferase, may play a role in steroid detoxification; forms volatile esters during fermentation, which is important for brewing and winemaking"	1	0	0	0	0	0	0.15	0
4842_OG5_193686_7 - FUNGI_YJR012C	YJR012C	"YJR012C - Essential protein of unknown function; proposed involvement in transport based on mass spectrometry analysis of copurifying proteins; partially overlaps neighboring ORF, GPI14/YJR013W"	1	0	0	0	0	0	0.15	0
4843_OG5_193748_7 - FUNGI_YDR131C	YDR131C	"YDR131C - F-box protein, substrate-specific adaptor subunit that recruits substrates to a core ubiquitination complex"	1	0	0	0	0	0	0.15	0
4844_OG5_193755_7 - FUNGI_YLR392C	YLR392C	ART10 - Protein of unknown function that contains 2 PY motifs and is ubiquinated by Rsp5p; overexpression confers resistance to arsenite; green fluorescent protein (GFP)-fusion protein localizes it to the cytoplasm; non-essential gene	1	0	0	0	0	0	0.15	0
4845_OG5_194772_7 - FUNGI_Q0060	Q0060	"AI3 - Endonuclease I-SceIII, encoded by a mobile group I intron within the mitochondrial COX1 gene"	1	0	0	0	0	0	0.15	0
4846_OG5_194775_7 - FUNGI_YGL013C	YGL013C	PDR1 - Zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes	1	0	0	0	0	0	0.15	0
4847_OG5_194776_7 - FUNGI_YPL272C	YPL272C	YPL272C - Putative protein of unknown function; gene expression induced in response to ketoconazole; YPL272C is not an essential gene	1	0	0	0	0	0	0.15	0
4848_OG5_194778_7 - FUNGI_YDR383C	YDR383C	"NKP1 - Non-essential kinetochore protein, subunit of the Ctf19 central kinetochore complex (Ctf19p-Mcm21p-Okp1p-Mcm22p-Mcm16p-Ctf3p-Chl4p-Mcm19p-Nkp1p-Nkp2p-Ame1p-Mtw1p)"	1	0	0	0	0	0	0.15	0
4849_OG5_194779_7 - FUNGI_YLR040C	YLR040C	YLR040C - Putative protein of unknown function; localizes to the cell wall; predicted to be a GPI-attached protein; upregulated by Mcm1p-Alpha1p transcription factor; partially overlaps the dubious ORF YLR041W; YLR040C is not essential	1	0	0	0	0	0	0.15	0
4850_OG5_194780_7 - FUNGI_YOR298W	YOR298W	MUM3 - Protein of unknown function involved in the organization of the outer spore wall layers; has similarity to the tafazzins superfamily of acyltransferases	1	0	0	0	0	0	0.15	0
4851_OG5_194781_7 - FUNGI_YLR194C	YLR194C	YLR194C - Structural constituent of the cell wall attached to the plasma membrane by a GPI-anchor; expression is upregulated in response to cell wall stress	1	0	0	0	0	0	0.15	0
4852_OG5_194782_7 - FUNGI_YLR190W	YLR190W	"MMR1 - Phosphorylated protein of the mitochondrial outer membrane, localizes only to mitochondria of the bud; interacts with Myo2p to mediate mitochondrial distribution to buds; mRNA is targeted to the bud via the transport system involving She2p"	1	0	0	0	0	0	0.15	0
4853_OG5_194784_7 - FUNGI_YCL063W	YCL063W	VAC17 - Phosphoprotein involved in vacuole inheritance; degraded in late M phase of the cell cycle; acts as a vacuole-specific receptor for myosin Myo2p	1	0	0	0	0	0	0.15	0
4854_OG5_194785_7 - FUNGI_YDR524C-B	YDR524C-B	YDR524C-B - Putative protein of unknown function	1	0	0	0	0	0	0.15	0
4855_OG5_194790_7 - FUNGI_YOR264W	YOR264W	"DSE3 - Daughter cell-specific protein, may help establish daughter fate"	1	0	0	0	0	0	0.15	0
4856_OG5_194791_7 - FUNGI_YNL327W	YNL327W	"EGT2 - Glycosylphosphatidylinositol (GPI)-anchored cell wall endoglucanase required for proper cell separation after cytokinesis, expression is activated by Swi5p and tightly regulated in a cell cycle-dependent manner"	1	0	0	0	0	0	0.15	0
4857_OG5_194794_7 - FUNGI_YBL010C	YBL010C	YBL010C - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein colocalizes with clathrin-coated vesicles	1	0	0	0	0	0	0.15	0
4858_OG5_194796_7 - FUNGI_YBR071W	YBR071W	YBR071W - Putative protein of unknown function; (GFP)-fusion and epitope-tagged proteins localize to the cytoplasm; mRNA expression may be regulated by the cell cycle and/or cell wall stress	1	0	0	0	0	0	0.15	0
4859_OG5_194797_7 - FUNGI_YML037C	YML037C	YML037C - Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene	1	0	0	0	0	0	0.15	0
4860_OG5_194798_7 - FUNGI_YDR222W	YDR222W	YDR222W - Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern	1	0	0	0	0	0	0.15	0
4861_OG5_194799_7 - FUNGI_YPL219W	YPL219W	"PCL8 - Cyclin, interacts with Pho85p cyclin-dependent kinase (Cdk) to phosphorylate and regulate glycogen synthase, also activates Pho85p for Glc8p phosphorylation"	1	0	0	0	0	0	0.15	0
4862_OG5_194801_7 - FUNGI_YLR049C	YLR049C	YLR049C - Putative protein of unknown function	1	0	0	0	0	0	0.15	0
4863_OG5_194802_7 - FUNGI_YPL018W	YPL018W	"CTF19 - Outer kinetochore protein, required for accurate mitotic chromosome segregation; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) that functions as a platform for kinetochore assembly"	1	0	0	0	0	0	0.15	0
4864_OG5_194803_7 - FUNGI_YDR422C	YDR422C	"SIP1 - Alternate beta-subunit of the Snf1p kinase complex, may confer substrate specificity; vacuolar protein containing KIS (Kinase-Interacting Sequence) and ASC (Association with Snf1 kinase Complex) domains involved in protein interactions"	1	0	0	0	0	0	0.15	0
4865_OG5_194806_7 - FUNGI_YGR015C	YGR015C	YGR015C - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion	1	0	0	0	0	0	0.15	0
4866_OG5_194808_7 - FUNGI_YPL186C	YPL186C	"UIP4 - Protein that interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates; detected in a phosphorylated state in the mitochondrial outer membrane; also detected in ER and nuclear envelope"	1	0	0	0	0	0	0.15	0
4867_OG5_194810_7 - FUNGI_YDR070C	YDR070C	"FMP16 - Putative protein of unknown function; proposed to be involved in responding to conditions of stress; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"	1	0	0	0	0	0	0.15	0
4868_OG5_194811_7 - FUNGI_YHR143W	YHR143W	"DSE2 - Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother; expression is repressed by cAMP"	1	0	0	0	0	0	0.15	0
4869_OG5_194812_7 - FUNGI_YIL119C	YIL119C	RPI1 - Putative transcriptional regulator; overexpression suppresses the heat shock sensitivity of wild-type RAS2 overexpression and also suppresses the cell lysis defect of an mpk1 mutation	1	0	0	0	0	0	0.15	0
4870_OG5_194813_7 - FUNGI_YIL122W	YIL122W	POG1 - Nuclear chromatin-associated protein of unknown function; overexpression promotes recovery from pheromone induced arrest and suppresses the stress sensitivity caused by a mutation in the E3 ubiquitin ligase Rsp5p; binds upstream of BAR1 and cell cycle-related genes; potential Cdc28p substrate; SBF regulated	1	0	0	0	0	0	0.15	0
4871_OG5_194814_7 - FUNGI_YDR303C	YDR303C	RSC3 - Component of the RSC chromatin remodeling complex; essential gene required for maintenance of proper ploidy and regulation of ribosomal protein genes and the cell wall/stress response; highly similar to Rsc30p	1	0	0	0	0	0	0.15	0
4872_OG5_194816_7 - FUNGI_YJL070C	YJL070C	"YJL070C - Putative protein of unknown function with similarity to AMP deaminases; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YJL070C is a non-essential gene"	1	0	0	0	0	0	0.15	0
4873_OG5_194818_7 - FUNGI_YLR376C	YLR376C	"PSY3 - Protein involved in a Rad51p-, Rad54p-dependent pathway for homologous recombination repair; deletion results in a mutator phenotype; deletion increases sensitivity to anticancer drugs oxaliplatin and cisplatin but not mitomycin C"	1	0	0	0	0	0	0.15	0
4874_OG5_194821_7 - FUNGI_YGL249W	YGL249W	ZIP2 - Meiosis-specific protein involved in normal synaptonemal complex formation and pairing between homologous chromosomes during meiosis	1	0	0	0	0	0	0.15	0
4875_OG5_194823_7 - FUNGI_YBR047W	YBR047W	"FMP23 - Putative protein of unknown function; proposed to be involved in iron or copper homeostasis; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"	1	0	0	0	0	0	0.15	0
4876_OG5_194824_7 - FUNGI_YLR301W	YLR301W	HRI1 - Protein of unknown function that interacts with Sec72p and Hrr25p	1	0	0	0	0	0	0.15	0
4877_OG5_194825_7 - FUNGI_YJR039W	YJR039W	"YJR039W - Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"	1	0	0	0	0	0	0.15	0
4878_OG5_194826_7 - FUNGI_YOR114W	YOR114W	YOR114W - Putative protein of unknown function; null mutant is viable	1	0	0	0	0	0	0.15	0
4879_OG5_194828_7 - FUNGI_YNR009W	YNR009W	NRM1 - Transcriptional co-repressor of MBF (MCB binding factor)-regulated gene expression; Nrm1p associates stably with promoters via MBF to repress transcription upon exit from G1 phase	1	0	0	0	0	0	0.15	0
4880_OG5_194829_7 - FUNGI_YJL158C	YJL158C	CIS3 - Mannose-containing glycoprotein constituent of the cell wall; member of the PIR (proteins with internal repeats) family	1	0	0	0	0	0	0.15	0
4881_OG5_194833_7 - FUNGI_YPR164W	YPR164W	MMS1 - Subunit of an E3 ubiquitin ligase complex involved in resolving replication intermediates or preventing the damage caused by blocked replication forks; regulates Ty1 transposition; involved with Rtt101p in nonfunctional rRNA decay	1	0	0	0	0	0	0.15	0
4882_OG5_194836_7 - FUNGI_YOR304C-A	YOR304C-A	"YOR304C-A - Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck"	1	0	0	0	0	0	0.15	0
4883_OG5_194837_7 - FUNGI_YGR126W	YGR126W	YGR126W - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS	1	0	0	0	0	0	0.15	0
4884_OG5_194841_7 - FUNGI_YJL047C	YJL047C	"RTT101 - Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex with a role in anaphase progression; implicated in Mms22-dependent DNA repair; involved with Mms1p in nonfunctional rRNA decay; modified by the ubiquitin-like protein, Rub1p"	1	0	0	0	0	0	0.15	0
4885_OG5_194843_7 - FUNGI_YML107C	YML107C	PML39 - Protein required for nuclear retention of unspliced pre-mRNAs along with Mlp1p and Pml1p; anchored to nuclear pore complex via Mlp1p and Mlp2p; found with the subset of nuclear pores farthest from the nucleolus; may interact with ribosomes	1	0	0	0	0	0	0.15	0
4886_OG5_194844_7 - FUNGI_YDL027C	YDL027C	"YDL027C - Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL027C is not an essential gene"	1	0	0	0	0	0	0.15	0
4887_OG5_194848_7 - FUNGI_YGL209W	YGL209W	"MIG2 - Protein containing zinc fingers, involved in repression, along with Mig1p, of SUC2 (invertase) expression by high levels of glucose; binds to Mig1p-binding sites in SUC2 promoter"	1	0	0	0	0	0	0.15	0
4888_OG5_194849_7 - FUNGI_YDR082W	YDR082W	"STN1 - Telomere end-binding and capping protein, plays a key role with Pol12p in linking telomerase action with completion of lagging strand synthesis, and in a regulatory step required for telomere capping"	1	0	0	0	0	0	0.15	0
4889_OG5_194851_7 - FUNGI_YEL048C	YEL048C	"TCA17 - Subunit of TRAPPII, a multimeric GEF involved in intra-Golgi and endosome-to-Golgi transport; promotes association of TRAPPII-specific subunits with the core complex; sedlin related; human Sedlin mutations cause SEDT, a skeletal disorder"	1	0	0	0	0	0	0.15	0
4890_OG5_194852_7 - FUNGI_YKL061W	YKL061W	BLI1 - Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome	1	0	0	0	0	0	0.15	0
4891_OG5_194854_7 - FUNGI_YKR045C	YKR045C	YKR045C - Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm	1	0	0	0	0	0	0.15	0
4892_OG5_194856_7 - FUNGI_YJL132W	YJL132W	YJL132W - Putative protein of unknown function; localizes to the membrane fraction; possible Zap1p-regulated target gene induced by zinc deficiency; YJL132W is a non-essential gene	1	0	0	0	0	0	0.15	0
4893_OG5_194858_7 - FUNGI_YPL033C	YPL033C	SRL4 - Protein of unknown function; involved in regulation of dNTP production; null mutant suppresses the lethality of lcd1 and rad53 mutations; expression is induced by Kar4p	1	0	0	0	0	0	0.15	0
4894_OG5_194861_7 - FUNGI_YPL039W	YPL039W	YPL039W - Putative protein of unknown function; YPL039W is not an essential gene	1	0	0	0	0	0	0.15	0
4895_OG5_194863_7 - FUNGI_YLR446W	YLR446W	YLR446W - Putative protein of unknown function with similarity to hexokinases; transcript is upregulated during sporulation and the unfolded protein response; YLR446W is not an essential gene	1	0	0	0	0	0	0.15	0
4896_OG5_194865_7 - FUNGI_YPL144W	YPL144W	POC4 - Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions	1	0	0	0	0	0	0.15	0
4897_OG5_194866_7 - FUNGI_YNL295W	YNL295W	YNL295W - Putative protein of unknown function	1	0	0	0	0	0	0.15	0
4898_OG5_194869_7 - FUNGI_YBR194W	YBR194W	"AIM4 - Protein proposed to be associated with the nuclear pore complex; null mutant is viable, displays elevated frequency of mitochondrial genome loss and is sensitive to freeze-thaw stress"	1	0	0	0	0	0	0.15	0
4899_OG5_194871_7 - FUNGI_YDR261C	YDR261C	"EXG2 - Exo-1,3-beta-glucanase, involved in cell wall beta-glucan assembly; may be anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor"	1	0	0	0	0	0	0.15	0
4900_OG5_194872_7 - FUNGI_YJR083C	YJR083C	"ACF4 - Protein of unknown function, computational analysis of large-scale protein-protein interaction data suggests a possible role in actin cytoskeleton organization; potential Cdc28p substrate"	1	0	0	0	0	0	0.15	0
4901_OG5_194875_7 - FUNGI_YLR102C	YLR102C	"APC9 - Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition"	1	0	0	0	0	0	0.15	0
4902_OG5_197051_7 - FUNGI_YMR191W	YMR191W	SPG5 - Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources	1	0	0	0	0	0	0.15	0
4903_OG5_200749_7 - FUNGI_YDL169C	YDL169C	"UGX2 - Protein of unknown function, transcript accumulates in response to any combination of stress conditions"	1	0	0	0	0	0	0.15	0
4904_OG5_200750_7 - FUNGI_YDR014W	YDR014W	"RAD61 - Subunit of a complex (Scc3p, Pds5p, Rad61p) that inhibits sister chromatid cohesion; inhibited by Eco1p-acetylated cohesin subunits Smc3p and Mcd1p; related to the human Wapl protein that controls the association of cohesin with chromatin"	1	0	0	0	0	0	0.15	0
4905_OG5_200752_7 - FUNGI_YNL210W	YNL210W	MER1 - Protein with RNA-binding motifs required for meiosis-specific mRNA splicing; required for chromosome pairing and meiotic recombination	1	0	0	0	0	0	0.15	0
4906_OG5_200754_7 - FUNGI_YPL267W	YPL267W	"ACM1 - Pseudosubstrate inhibitor of the anaphase-promoting complex/cyclosome (APC/C), that suppresses APC/C [Cdh1]-mediated proteolysis of mitotic cyclins; associates with Cdh1p, Bmh1p and Bmh2p; cell cycle regulated protein"	1	0	0	0	0	0	0.15	0
4907_OG5_200756_7 - FUNGI_YIL024C	YIL024C	YIL024C - Putative protein of unknown function; non-essential gene; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p	1	0	0	0	0	0	0.15	0
4908_OG5_200758_7 - FUNGI_YMR148W	YMR148W	OSW5 - Protein of unknown function that may play a role in spore wall assembly; predicted to contain an N-terminal transmembrane domain; osw5 null mutant spores exhibit increased spore wall permeability and sensitivity to beta-glucanase digestion	1	0	0	0	0	0	0.15	0
4909_OG5_200759_7 - FUNGI_YJL170C	YJL170C	ASG7 - Protein that regulates signaling from a G protein beta subunit Ste4p and its relocalization within the cell; specific to a-cells and induced by alpha-factor	1	0	0	0	0	0	0.15	0
4910_OG5_200760_7 - FUNGI_YMR107W	YMR107W	SPG4 - Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources	1	0	0	0	0	0	0.15	0
4911_OG5_200761_7 - FUNGI_YMR111C	YMR111C	YMR111C - Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR111C is not an essential gene	1	0	0	0	0	0	0.15	0
4912_OG5_200762_7 - FUNGI_YGL081W	YGL081W	"YGL081W - Putative protein of unknown function; non-essential gene; interacts genetically with CHS5, a gene involved in chitin biosynthesis"	1	0	0	0	0	0	0.15	0
4913_OG5_200763_7 - FUNGI_YHR185C	YHR185C	"PFS1 - Sporulation protein required for prospore membrane formation at selected spindle poles, ensures functionality of all four spindle pole bodies during meiosis II; not required for meiotic recombination or meiotic chromosome segregation"	1	0	0	0	0	0	0.15	0
4914_OG5_200764_7 - FUNGI_YGL226C-A	YGL226C-A	"OST5 - Zeta subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins"	1	0	0	0	0	0	0.15	0
4915_OG5_200766_7 - FUNGI_YCR043C	YCR043C	YCR043C - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi apparatus; YCR043C is not an essential gene	1	0	0	0	0	0	0.15	0
4916_OG5_200771_7 - FUNGI_YLR091W	YLR091W	"GEP5 - Protein of unknown function, required for mitochondrial genome maintenance; detected in highly purified mitochondria in high-throughput studies; null mutant has decreased levels of cardiolipin and phosphatidylethanolamine"	1	0	0	0	0	0	0.15	0
4917_OG5_200772_7 - FUNGI_YDR073W	YDR073W	SNF11 - Subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; interacts with a highly conserved 40-residue sequence of Snf2p	1	0	0	0	0	0	0.15	0
4918_OG5_200773_7 - FUNGI_YLR227C	YLR227C	"ADY4 - Structural component of the meiotic outer plaque, which is a membrane-organizing center that assembles on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane"	1	0	0	0	0	0	0.15	0
4919_OG5_200774_7 - FUNGI_YBR255C-A	YBR255C-A	YBR255C-A - Putative protein of unknown function; may interact with respiratory chain complexes III (ubiquinol-cytochrome c reductase) or IV (cytochrome c oxidase); identified by sequence comparison with hemiascomycetous yeast species	1	0	0	0	0	0	0.15	0
4920_OG5_200775_7 - FUNGI_YLR012C	YLR012C	YLR012C - Putative protein of unknown function; YLR012C is not an essential gene	1	0	0	0	0	0	0.15	0
4921_OG5_200776_7 - FUNGI_YGL146C	YGL146C	"RRT6 - Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; contains two putative transmembrane spans, but no significant homology to other known proteins"	1	0	0	0	0	0	0.15	0
4922_OG5_200777_7 - FUNGI_YBR058C-A	YBR058C-A	"TSC3 - Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis"	1	0	0	0	0	0	0.15	0
4923_OG5_133324_7 - FUNGI_YOL164W	YOL164W	BDS1 - Bacterially-derived sulfatase required for use of alkyl- and aryl-sulfates as sulfur sources	1	0	0.194444444	0	0.142857143	0.071428571	0.1	0.125
4924_OG5_139188_7 - FUNGI_YOR106W	YOR106W	VAM3 - Syntaxin-like vacuolar t-SNARE that functions with Vam7p in vacuolar protein trafficking; mediates docking/fusion of late transport intermediates with the vacuole; has an acidic di-leucine sorting signal and C-terminal transmembrane region	1	0	0	0	0.095238095	0	0.1	0.125
4925_OG5_158521_7 - FUNGI_YJL056C	YJL056C	"ZAP1 - Zinc-regulated transcription factor; binds to zinc-responsive promoters to induce transcription of certain genes in presence of zinc, represses other genes in low zinc; regulates its own transcription; contains seven zinc-finger domains"	1	0	0	0	0.047619048	0.071428571	0.1	0
4926_OG5_169883_7 - FUNGI_YOR010C	YOR010C	TIR2 - Putative cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; transcription is induced by cold shock and anaerobiosis	1	0	0	0	0.047619048	0	0.1	0
4927_OG5_169883_7 - FUNGI_YER011W	YER011W	TIR1 - Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expression is downregulated at acidic pH and induced by cold shock and anaerobiosis; abundance is increased in cells cultured without shaking	1	0	0	0	0.047619048	0	0.1	0
4928_OG5_177969_7 - FUNGI_YMR136W	YMR136W	GAT2 - Protein containing GATA family zinc finger motifs; similar to Gln3p and Dal80p; expression repressed by leucine	1	0	0	0	0.047619048	0	0.1	0
4929_OG5_180481_7 - FUNGI_YGR023W	YGR023W	"MTL1 - Putative plasma membrane sensor, involved in cell integrity signaling and stress response during glucose starvation and oxidative stress; has structural and functional similarity to Mid2p"	1	0	0	0	0.047619048	0	0.1	0
4930_OG5_203836_7 - FUNGI_YNR062C	YNR062C	YNR062C - Putative membrane protein of unknown function	1	0	0	0	0.047619048	0	0.1	0
4931_OG5_180485_7 - FUNGI_YDR534C	YDR534C	"FIT1 - Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall"	1	0.0625	0	0	0	0	0.1	0.0625
4932_OG5_159685_7 - FUNGI_YJR151C	YJR151C	"DAN4 - Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth"	1	0	0.027777778	0.125	0	0	0.1	0.0625
4933_OG5_177137_7 - FUNGI_YDR374C	YDR374C	YDR374C - Putative protein of unknown function	1	0	0	0.125	0	0	0.1	0
4934_OG5_140504_7 - FUNGI_YLL022C	YLL022C	"HIF1 - Non-essential component of the HAT-B histone acetyltransferase complex (Hat1p-Hat2p-Hif1p), localized to the nucleus; has a role in telomeric silencing"	1	0	0	0	0	0	0.1	0.375
4935_OG5_174060_7 - FUNGI_YOR387C	YOR387C	YOR387C - Putative protein of unknown function; regulated by the metal-responsive Aft1p transcription factor; highly inducible in zinc-depleted conditions; localizes to the soluble fraction	1	0	0	0	0	0	0.1	0
4936_OG5_174060_7 - FUNGI_YGL258W	YGL258W	VEL1 - Protein of unknown function; highly induced in zinc-depleted conditions and has increased expression in NAP1 deletion mutants	1	0	0	0	0	0	0.1	0
4937_OG5_180508_7 - FUNGI_YNL195C	YNL195C	"YNL195C - Putative protein of unknown function; shares a promoter with YNL194C; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"	1	0	0	0	0	0	0.1	0.125
4938_OG5_181374_7 - FUNGI_YOR383C	YOR383C	"FIT3 - Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall"	1	0	0	0	0	0	0.1	0
4939_OG5_193777_7 - FUNGI_YDL232W	YDL232W	"OST4 - Subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes protein asparagine-linked glycosylation; type I membrane protein required for incorporation of Ost3p or Ost6p into the OST complex"	1	0	0	0	0	0	0.1	0
4940_OG5_194846_7 - FUNGI_YOR385W	YOR385W	YOR385W - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YOR385W is not an essential gene	1	0	0	0	0	0	0.1	0
4941_OG5_194846_7 - FUNGI_YMR316W	YMR316W	"DIA1 - Protein of unknown function, involved in invasive and pseudohyphal growth; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern"	1	0	0	0	0	0	0.1	0
4942_OG5_194847_7 - FUNGI_YOR247W	YOR247W	"SRL1 - Mannoprotein that exhibits a tight association with the cell wall, required for cell wall stability in the absence of GPI-anchored mannoproteins; has a high serine-threonine content; expression is induced in cell wall mutants"	1	0	0	0	0	0	0.1	0
4943_OG5_194847_7 - FUNGI_YPL163C	YPL163C	"SVS1 - Cell wall and vacuolar protein, required for wild-type resistance to vanadate"	1	0	0	0	0	0	0.1	0
4944_OG5_197453_7 - FUNGI_YOL082W	YOL082W	ATG19 - Receptor protein specific for the cytoplasm-to-vacuole targeting (Cvt) pathway; delivers cargo proteins aminopeptidase I (Lap4p) and alpha-mannosidase (Ams1p) to the phagophore assembly site for packaging into Cvt vesicles	1	0	0	0	0	0	0.1	0
4945_OG5_197453_7 - FUNGI_YOL083W	YOL083W	ATG34 - Receptor protein involved in selective autophagy during starvation; specifically involved in the transport of cargo protein alpha-mannosidase (Ams1p); Atg19p paralog	1	0	0	0	0	0	0.1	0
4946_OG5_200765_7 - FUNGI_YGR071C	YGR071C	YGR071C - Putative protein of unknown function; deletion mutant has increased glycogen accumulation and displays elongated buds; green fluorescent protein (GFP)-fusion protein localizes to the nucleus	1	0	0	0	0	0	0.1	0
4947_OG5_200765_7 - FUNGI_YLR373C	YLR373C	"VID22 - Glycosylated integral membrane protein localized to the plasma membrane; plays a role in fructose-1,6-bisphosphatase (FBPase) degradation; involved in FBPase transport from the cytosol to Vid (vacuole import and degradation) vesicles"	1	0	0	0	0	0	0.1	0
4948_OG5_207831_7 - FUNGI_YCR048W	YCR048W	"ARE1 - Acyl-CoA:sterol acyltransferase, isozyme of Are2p; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the absence of oxygen"	1	0	0	0	0	0	0.1	0
4949_OG5_209495_7 - FUNGI_YJR015W	YJR015W	YJR015W - Putative protein of unknown function; localizes to the endoplasmic reticulum and cytoplasm; predicted to encode a membrane transporter based on phylogenetic analysis; YJR015W is a non-essential gene	1	0	0	0	0	0	0.1	0
4950_OG5_210501_7 - FUNGI_YLR108C	YLR108C	YLR108C - Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YLR108C is not an esssential gene	1	0	0	0	0	0	0.1	0
4951_OG5_210513_7 - FUNGI_YGR169C-A	YGR169C-A	YGR169C-A - Putative protein of unknown function	1	0	0	0	0	0	0.1	0
4952_OG5_210918_7 - FUNGI_YNR063W	YNR063W	YNR063W - Putative zinc-cluster protein of unknown function	1	0	0	0	0	0	0.1	0
4953_OG5_213226_7 - FUNGI_YPR200C	YPR200C	ARR2 - Arsenate reductase required for arsenate resistance; converts arsenate to arsenite which can then be exported from cells by Arr3p	1	0	0	0	0	0	0.1	0
4954_OG5_216254_7 - FUNGI_YGR180C	YGR180C	"RNR4 - Ribonucleotide-diphosphate reductase (RNR), small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits"	1	0	0	0	0	0	0.1	0
4955_OG5_216329_7 - FUNGI_YJL065C	YJL065C	"DLS1 - Subunit of ISW2/yCHRAC chromatin accessibility complex along with Itc1p, Isw2p, and Dpb4p; involved in inheritance of telomeric silencing"	1	0	0	0	0	0	0.1	0
4956_OG5_216698_7 - FUNGI_YPL189C-A	YPL189C-A	COA2 - Cytochrome oxidase assembly factor; null mutation results in respiratory deficiency with specific loss of cytochrome oxidase activity; functions downstream of assembly factors Mss51p and Coa1p and interacts with assembly factor Shy1p	1	0	0	0	0	0	0.1	0
4957_OG5_222350_7 - FUNGI_YGL032C	YGL032C	"AGA2 - Adhesion subunit of a-agglutinin of a-cells, C-terminal sequence acts as a ligand for alpha-agglutinin (Sag1p) during agglutination, modified with O-linked oligomannosyl chains, linked to anchorage subunit Aga1p via two disulfide bonds"	1	0	0	0	0	0	0.1	0
4958_OG5_222351_7 - FUNGI_YFR017C	YFR017C	IGD1 - Inhibitor of glycogen debranching; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YFR017C is not an essential gene	1	0	0	0	0	0	0.1	0
4959_OG5_222352_7 - FUNGI_YOL025W	YOL025W	"LAG2 - Protein that negatively regulates the SCF E3-ubiquitin ligase by interacting with and preventing neddyation of the cullin subunit, Cdc53p; longevity determinant that is preferentially expressed in young cells; similar to mammalian Cand1"	1	0	0	0	0	0	0.1	0
4960_OG5_222355_7 - FUNGI_YBL059W	YBL059W	"YBL059W - Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"	1	0	0	0	0	0	0.1	0
4961_OG5_222359_7 - FUNGI_YBL085W	YBL085W	"BOI1 - Protein implicated in polar growth, functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain"	1	0	0	0	0	0	0.1	0
4962_OG5_222360_7 - FUNGI_YFR046C	YFR046C	"CNN1 - Kinetochore protein of unknown function; associated with the essential kinetochore proteins Nnf1p and Spc24p; phosphorylated by both Clb5-Cdk1 and, to a lesser extent, Clb2-Cdk1."	1	0	0	0	0	0	0.1	0
4963_OG5_222361_7 - FUNGI_YFR039C	YFR039C	YFR039C - Putative protein of unknown function; may be involved in response to high salt and changes in carbon source; deletion mutant has decreased spore survival in Drosophila feces	1	0	0	0	0	0	0.1	0
4964_OG5_222365_7 - FUNGI_YOR350C	YOR350C	MNE1 - Mitochondrial matrix protein involved in splicing Group I aI5-beta intron from COX1 mRNA	1	0	0	0	0	0	0.1	0
4965_OG5_222366_7 - FUNGI_YHR061C	YHR061C	"GIC1 - Protein of unknown function involved in initiation of budding and cellular polarization, interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain"	1	0	0	0	0	0	0.1	0
4966_OG5_222367_7 - FUNGI_YDR014W-A	YDR014W-A	"HED1 - Meiosis-specific protein that down-regulates Rad51p-mediated mitotic recombination when the meiotic recombination machinery is impaired; early meiotic gene, transcribed specifically during meiotic prophase"	1	0	0	0	0	0	0.1	0
4967_OG5_222369_7 - FUNGI_YDR146C	YDR146C	SWI5 - Transcription factor that activates transcription of genes expressed at the M/G1 phase boundary and in G1 phase; localization to the nucleus occurs during G1 and appears to be regulated by phosphorylation by Cdc28p kinase	1	0	0	0	0	0	0.1	0
4968_OG5_222373_7 - FUNGI_YHL038C	YHL038C	"CBP2 - Mitochondrial protein required for splicing of the group I intron aI5 of the COB pre-mRNA, binds to the RNA to promote splicing; also involved in but not essential for splicing of the COB bI2 intron and the intron in the 21S rRNA gene"	1	0	0	0	0	0	0.1	0
4969_OG5_222375_7 - FUNGI_YOL047C	YOL047C	YOL047C - Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern	1	0	0	0	0	0	0.1	0
4970_OG5_222377_7 - FUNGI_YDR423C	YDR423C	"CAD1 - AP-1-like basic leucine zipper (bZIP) transcriptional activator involved in stress responses, iron metabolism, and pleiotropic drug resistance; controls a set of genes involved in stabilizing proteins; binds consensus sequence TTACTAA"	1	0	0	0	0	0	0.1	0
4971_OG5_222379_7 - FUNGI_YLR413W	YLR413W	YLR413W - Putative protein of unknown function; YLR413W is not an essential gene	1	0	0	0	0	0	0.1	0
4972_OG5_222381_7 - FUNGI_YMR042W	YMR042W	ARG80 - Transcription factor involved in regulation of arginine-responsive genes; acts with Arg81p and Arg82p	1	0	0	0	0	0	0.1	0
4973_OG5_222382_7 - FUNGI_YGL121C	YGL121C	GPG1 - Proposed gamma subunit of the heterotrimeric G protein that interacts with the receptor Gpr1p; involved in regulation of pseudohyphal growth; requires Gpb1p or Gpb2p to interact with Gpa2p; overproduction causes prion curing	1	0	0	0	0	0	0.1	0
4974_OG5_222383_7 - FUNGI_YGL117W	YGL117W	YGL117W - Putative protein of unknown function	1	0	0	0	0	0	0.1	0
4975_OG5_222384_7 - FUNGI_YGR236C	YGR236C	"SPG1 - Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"	1	0	0	0	0	0	0.1	0
4976_OG5_222385_7 - FUNGI_YLR315W	YLR315W	"NKP2 - Non-essential kinetochore protein, subunit of the Ctf19 central kinetochore complex (Ctf19p-Mcm21p-Okp1p-Mcm22p-Mcm16p-Ctf3p-Chl4p-Mcm19p-Nkp1p-Nkp2p-Ame1p-Mtw1p)"	1	0	0	0	0	0	0.1	0
4977_OG5_222386_7 - FUNGI_YER184C	YER184C	"YER184C - Putative zinc cluster protein; deletion confers sensitivity to Calcufluor white, and prevents growth on glycerol or lactate as sole carbon source"	1	0	0	0	0	0	0.1	0
4978_OG5_222387_7 - FUNGI_YLR341W	YLR341W	"SPO77 - Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis"	1	0	0	0	0	0	0.1	0
4979_OG5_222389_7 - FUNGI_YDL080C	YDL080C	"THI3 - Probable alpha-ketoisocaproate decarboxylase, may have a role in catabolism of amino acids to long-chain and complex alcohols; required for expression of enzymes involved in thiamine biosynthesis"	1	0	0	0	0	0	0.1	0
4980_OG5_222392_7 - FUNGI_YDL227C	YDL227C	"HO - Site-specific endonuclease required for gene conversion at the MAT locus (homothallic switching) through the generation of a ds DNA break; expression restricted to mother cells in late G1 as controlled by Swi4p-Swi6p, Swi5p and Ash1p"	1	0	0	0	0	0	0.1	0
4981_OG5_222393_7 - FUNGI_YDL218W	YDL218W	YDL218W - Putative protein of unknown function; YDL218W transcription is regulated by Azf1p and induced by starvation and aerobic conditions; expression also induced in cells treated with the mycotoxin patulin	1	0	0	0	0	0	0.1	0
4982_OG5_222394_7 - FUNGI_YPL201C	YPL201C	YIG1 - Protein that interacts with glycerol 3-phosphatase and plays a role in anaerobic glycerol production; localizes to the nucleus and cytosol	1	0	0	0	0	0	0.1	0
4983_OG5_222397_7 - FUNGI_YGL090W	YGL090W	LIF1 - Component of the DNA ligase IV complex that mediates nonhomologous end joining in DNA double-strand break repair; physically interacts with Dnl4p and Nej1p; homologous to mammalian XRCC4 protein	1	0	0	0	0	0	0.1	0
4984_OG5_222404_7 - FUNGI_YBR036C	YBR036C	"CSG2 - Endoplasmic reticulum membrane protein, required for mannosylation of inositolphosphorylceramide and for growth at high calcium concentrations"	1	0	0	0	0	0	0.1	0
4985_OG5_222405_7 - FUNGI_YJL209W	YJL209W	CBP1 - Mitochondrial protein that interacts with the 5'-untranslated region of the COB mRNA and has a role in its stability and translation; found in a complex at the inner membrane along with Pet309p	1	0	0	0	0	0	0.1	0
4986_OG5_222407_7 - FUNGI_YBR259W	YBR259W	YBR259W - Putative protein of unknown function; YBR259W is not an essential gene	1	0	0	0	0	0	0.1	0
4987_OG5_222410_7 - FUNGI_YFR036W	YFR036W	"CDC26 - Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition"	1	0	0	0	0	0	0.1	0
4988_OG5_222413_7 - FUNGI_YNL146W	YNL146W	YNL146W - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YNL146W is not an essential gene	1	0	0	0	0	0	0.1	0
4989_OG5_222414_7 - FUNGI_YNL160W	YNL160W	YGP1 - Cell wall-related secretory glycoprotein; induced by nutrient deprivation-associated growth arrest and upon entry into stationary phase; may be involved in adaptation prior to stationary phase entry; has similarity to Sps100p	1	0	0	0	0	0	0.1	0
4990_OG5_222419_7 - FUNGI_YKL208W	YKL208W	"CBT1 - Protein involved in 5' end processing of mitochondrial COB, 15S_rRNA, and RPM1 transcripts; may also have a role in 3' end processing of the COB pre-mRNA; displays genetic interaction with cell cycle-regulated kinase Dbf2p"	1	0	0	0	0	0	0.1	0
4991_OG5_222422_7 - FUNGI_YGR049W	YGR049W	"SCM4 - Potential regulatory effector of CDC4 function, suppresses a temperature-sensitive allele of CDC4, tripartite protein structure in which a charged region separates two uncharged domains, not essential for mitosis or meiosis"	1	0	0	0	0	0	0.1	0
4992_OG5_222424_7 - FUNGI_YLR267W	YLR267W	BOP2 - Protein of unknown function	1	0	0	0	0	0	0.1	0
4993_OG5_222426_7 - FUNGI_YIR018W	YIR018W	YAP5 - Basic leucine zipper (bZIP) transcription factor	1	0	0	0	0	0	0.1	0
4994_OG5_222428_7 - FUNGI_YDR227W	YDR227W	"SIR4 - Silent information regulator that, together with SIR2 and SIR3, is involved in assembly of silent chromatin domains at telomeres and the silent mating-type loci; potentially phosphorylated by Cdc28p; some alleles of SIR4 prolong lifespan"	1	0	0	0	0	0	0.1	0
4995_OG5_222430_7 - FUNGI_YIL040W	YIL040W	"APQ12 - Protein required for nuclear envelope morphology, nuclear pore complex localization, mRNA export from the nucleus; exhibits synthetic lethal genetic interactions with genes involved in lipid metabolism"	1	0	0	0	0	0	0.1	0
4996_OG5_222434_7 - FUNGI_YOR097C	YOR097C	YOR097C - Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen; YOR097C is not an essential gene	1	0	0	0	0	0	0.1	0
4997_OG5_222436_7 - FUNGI_YKL079W	YKL079W	"SMY1 - Protein that interacts with Myo2p, proposed to be involved in exocytosis; N-terminal domain is related to the motor domain of kinesins"	1	0	0	0	0	0	0.1	0
4998_OG5_222437_7 - FUNGI_YGL176C	YGL176C	YGL176C - Putative protein of unknown function; deletion mutant is viable and has no detectable phenotype	1	0	0	0	0	0	0.1	0
4999_OG5_222439_7 - FUNGI_YOR044W	YOR044W	IRC23 - Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; null mutant displays increased levels of spontaneous Rad52p foci	1	0	0	0	0	0	0.1	0
5000_OG5_222441_7 - FUNGI_YBR076W	YBR076W	ECM8 - Non-essential protein of unknown function	1	0	0	0	0	0	0.1	0
5001_OG5_222443_7 - FUNGI_YPL130W	YPL130W	SPO19 - Meiosis-specific prospore protein; required to produce bending force necessary for proper assembly of the prospore membrane during sporulation; identified as a weak high-copy suppressor of the spo1-1 ts mutation	1	0	0	0	0	0	0.1	0
5002_OG5_222445_7 - FUNGI_YBR188C	YBR188C	"NTC20 - Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs"	1	0	0	0	0	0	0.1	0
5003_OG5_222446_7 - FUNGI_YHR195W	YHR195W	"NVJ1 - Nuclear envelope protein, anchored to the nuclear inner membrane, that interacts with the vacuolar membrane protein Vac8p to promote formation of nucleus-vacuole junctions during piecemeal microautophagy of the nucleus (PMN)"	1	0	0	0	0	0	0.1	0
5004_OG5_222447_7 - FUNGI_YMR025W	YMR025W	"CSI1 - Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling"	1	0	0	0	0	0	0.1	0
5005_OG5_222449_7 - FUNGI_YDR260C	YDR260C	"SWM1 - Subunit of the anaphase-promoting complex, which is an E3 ubiquitin ligase that regulates the metaphase-anaphase transition and exit from mitosis; required for activation of the daughter-specific gene expression and spore wall maturation"	1	0	0	0	0	0	0.1	0
5006_OG5_222450_7 - FUNGI_YJR094C	YJR094C	"IME1 - Master regulator of meiosis that is active only during meiotic events, activates transcription of early meiotic genes through interaction with Ume6p, degraded by the 26S proteasome following phosphorylation by Ime2p"	1	0	0	0	0	0	0.1	0
5007_OG5_231703_7 - FUNGI_YGL057C	YGL057C	"GEP7 - Protein of unknown function; null mutant exhibits a respiratory growth defect and synthetic interactions with prohibitin (phb1) and gem1; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"	1	0	0	0	0	0	0.1	0
5008_OG5_231714_7 - FUNGI_YML083C	YML083C	YML083C - Putative protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; strong increase in transcript abundance during anaerobic growth compared to aerobic growth; cells deleted for YML083C do not exhibit growth defects in anerobic or anaerobic conditions	1	0	0	0	0	0	0.1	0
5009_OG5_231718_7 - FUNGI_YER044C-A	YER044C-A	MEI4 - Meiosis-specific protein involved in double-strand break formation during meiotic recombination; required for chromosome synapsis and production of viable spores	1	0	0	0	0	0	0.1	0
5010_OG5_231724_7 - FUNGI_YCR020W-B	YCR020W-B	"HTL1 - Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance"	1	0	0	0	0	0	0.1	0
5011_OG5_231730_7 - FUNGI_YCR075W-A	YCR075W-A	YCR075W-A - Putative protein of unknown function; identified by homology to Ashbya gossypii	1	0	0	0	0	0	0.1	0
5012_OG5_231732_7 - FUNGI_YLR254C	YLR254C	"NDL1 - Homolog of nuclear distribution factor NudE, NUDEL; interacts with Pac1p and regulates dynein targeting to microtubule plus ends"	1	0	0	0	0	0	0.1	0
5013_OG5_231736_7 - FUNGI_YGL194C-A	YGL194C-A	"YGL194C-A - Putative protein of unknown function, identified based on comparisons of the genome sequences of six Saccharomyces species"	1	0	0	0	0	0	0.1	0
5014_OG5_231744_7 - FUNGI_YOR302W	YOR302W	"YOR302W - CPA1 uORF, Arginine attenuator peptide, regulates translation of the CPA1 mRNA"	1	0	0	0	0	0	0.1	0
5015_OG5_231750_7 - FUNGI_YBL039W-B	YBL039W-B	YBL039W-B - Putative protein of unknown function	1	0	0	0	0	0	0.1	0
5016_OG5_231751_7 - FUNGI_YCL048W-A	YCL048W-A	YCL048W-A - Putative protein of unknown function	1	0	0	0	0	0	0.1	0
5017_OG5_231756_7 - FUNGI_YPL096C-A	YPL096C-A	ERI1 - Endoplasmic reticulum membrane protein that binds to and inhibits GTP-bound Ras2p at the ER; component of the GPI-GnT complex which catalyzes the first step in GPI-anchor biosynthesis; probable homolog of mammalian PIG-Y protein	1	0	0	0	0	0	0.1	0
5018_OG5_231757_7 - FUNGI_YKL138C-A	YKL138C-A	"HSK3 - Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis"	1	0	0	0	0	0	0.1	0
5019_OG5_235231_7 - FUNGI_YKR005C	YKR005C	YKR005C - Putative protein of unknown function	1	0	0	0	0	0	0.1	0
5020_OG5_235233_7 - FUNGI_YJL133C-A	YJL133C-A	"YJL133C-A - Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"	1	0	0	0	0	0	0.1	0
5021_OG5_235234_7 - FUNGI_YNL300W	YNL300W	"TOS6 - Glycosylphosphatidylinositol-dependent cell wall protein, expression is periodic and decreases in respone to ergosterol perturbation or upon entry into stationary phase; depletion increases resistance to lactic acid"	1	0	0	0	0	0	0.1	0
5022_OG5_235240_7 - FUNGI_YNR056C	YNR056C	"BIO5 - Putative transmembrane protein involved in the biotin biosynthesis pathway; responsible for uptake of 7-keto 8-aminopelargonic acid; BIO5 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis"	1	0	0	0	0	0	0.1	0
5023_OG5_235244_7 - FUNGI_YJL161W	YJL161W	"FMP33 - Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"	1	0	0	0	0	0	0.1	0
5024_OG5_235248_7 - FUNGI_YPR134W	YPR134W	MSS18 - Nuclear encoded protein needed for efficient splicing of mitochondrial COX1 aI5beta intron; mss18 mutations block cleavage of 5' exon - intron junction; phenotype of intronless strain suggests additional functions	1	0	0	0	0	0	0.1	0
5025_OG5_235251_7 - FUNGI_YCL056C	YCL056C	"PEX34 - Peroxisomal integral membrane protein that regulates peroxisome populations; interacts with Pex11p, Pex25p, and Pex27p to control both constitutive peroxisome division and peroxisome morphology and abundance during peroxisome proliferation"	1	0	0	0	0	0	0.1	0
5026_OG5_235255_7 - FUNGI_YML113W	YML113W	DAT1 - DNA binding protein that recognizes oligo(dA).oligo(dT) tracts; Arg side chain in its N-terminal pentad Gly-Arg-Lys-Pro-Gly repeat is required for DNA-binding; not essential for viability	1	0	0	0	0	0	0.1	0
5027_OG5_235261_7 - FUNGI_YPR199C	YPR199C	"ARR1 - Transcriptional activator of the basic leucine zipper (bZIP) family, required for transcription of genes involved in resistance to arsenic compounds"	1	0	0	0	0	0	0.1	0
5028_OG5_235263_7 - FUNGI_YMR206W	YMR206W	YMR206W - Putative protein of unknown function; YMR206W is not an essential gene	1	0	0	0	0	0	0.1	0
5029_OG5_235265_7 - FUNGI_YER180C-A	YER180C-A	"SLO1 - Protein interacting with Arl3p, which is a GTPase of the Ras superfamily involved in vesicle-tethering at the Golgi; putative ortholog of human SCOCO"	1	0	0	0	0	0	0.1	0
5030_OG5_235267_7 - FUNGI_YLR265C	YLR265C	NEJ1 - Protein involved in regulation of nonhomologous end joining; interacts with DNA ligase IV components Dnl4p and Lif1p; repressed by MAT heterozygosity; regulates cellular distribution of Lif1p	1	0	0	0	0	0	0.1	0
5031_OG5_171197_7 - FUNGI_YOR031W	YOR031W	"CRS5 - Copper-binding metallothionein, required for wild-type copper resistance"	1	0	0	0	0.142857143	0.071428571	0.05	0
5032_OG5_163298_7 - FUNGI_YDR518W	YDR518W	"EUG1 - Protein disulfide isomerase of the endoplasmic reticulum lumen, function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER"	1	0	0	0	0.142857143	0	0.05	0.0625
5033_OG5_176586_7 - FUNGI_YMR219W	YMR219W	"ESC1 - Protein localized to the nuclear periphery, involved in telomeric silencing; interacts with PAD4-domain of Sir4p"	1	0	0	0	0.142857143	0	0.05	0
5034_OG5_186931_7 - FUNGI_YPR065W	YPR065W	ROX1 - Heme-dependent repressor of hypoxic genes; contains an HMG domain that is responsible for DNA bending activity	1	0	0	0	0.095238095	0	0.05	0
5035_OG5_194076_7 - FUNGI_YJL151C	YJL151C	"SNA3 - Integral membrane protein localized to vacuolar intralumenal vesicles, computational analysis of large-scale protein-protein interaction data suggests a possible role in either cell wall synthesis or protein-vacuolar targeting"	1	0	0	0	0.095238095	0	0.05	0
5036_OG5_194154_7 - FUNGI_YKR010C	YKR010C	TOF2 - Protein required for rDNA silencing and mitotic rDNA condensation; stimulates Cdc14p phosphatase activity and biphasic release to promote rDNA repeat segregation; required for condensin recruitment to the replication fork barrier site	1	0	0	0	0.095238095	0	0.05	0
5037_OG5_136820_7 - FUNGI_YFL067W	YFL067W	"YFL067W - Protein of unknown function, down-regulated at low calcium levels"	1	0	0.027777778	0	0.047619048	0.142857143	0.05	0.125
5038_OG5_159225_7 - FUNGI_YJL217W	YJL217W	"REE1 - Cytoplasmic protein involved in the regulation of enolase (ENO1); mRNA expression is induced by calcium shortage, copper deficiency (via Mac1p) and the presence of galactose (via Gal4p); mRNA expression is also regulated by the cell cycle"	1	0	0.083333333	0	0.047619048	0.071428571	0.05	0.0625
5039_OG5_132606_7 - FUNGI_YEL075C	YEL075C	YEL075C - Putative protein of unknown function	1	0	0	0	0.047619048	0	0.05	0.0625
5040_OG5_132606_7 - FUNGI_YER189W	YER189W	YER189W - Putative protein of unknown function	1	0	0	0	0.047619048	0	0.05	0.0625
5041_OG5_132606_7 - FUNGI_YHL049C	YHL049C	YHL049C - Putative protein of unknown function	1	0	0	0	0.047619048	0	0.05	0.0625
5042_OG5_132606_7 - FUNGI_YBL112C	YBL112C	YBL112C - Putative protein of unknown function; YBL112C is contained within TEL02L	1	0	0	0	0.047619048	0	0.05	0.0625
5043_OG5_132606_7 - FUNGI_YEL076C	YEL076C	YEL076C - Putative protein of unknown function	1	0	0	0	0.047619048	0	0.05	0.0625
5044_OG5_132606_7 - FUNGI_YEL076C-A	YEL076C-A	YEL076C-A - Putative protein of unknown function	1	0	0	0	0.047619048	0	0.05	0.0625
5045_OG5_132606_7 - FUNGI_YFL064C	YFL064C	YFL064C - Putative protein of unknown function	1	0	0	0	0.047619048	0	0.05	0.0625
5046_OG5_132606_7 - FUNGI_YFL065C	YFL065C	YFL065C - Putative protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation	1	0	0	0	0.047619048	0	0.05	0.0625
5047_OG5_132606_7 - FUNGI_YHL050C	YHL050C	"YHL050C - Putative protein of unknown function, potential Cdc28p substrate"	1	0	0	0	0.047619048	0	0.05	0.0625
5048_OG5_132606_7 - FUNGI_YHR219W	YHR219W	YHR219W - Putative protein of unknown function with similarity to helicases; located in the telomere region on the right arm of chromosome VIII	1	0	0	0	0.047619048	0	0.05	0.0625
5049_OG5_132606_7 - FUNGI_YIL177C	YIL177C	YIL177C - Putative protein of unknown function; similarity to DNA helicases that are encoded within subtelomeric Y' elements and induced in telomerase deficient survivors	1	0	0	0	0.047619048	0	0.05	0.0625
5050_OG5_132606_7 - FUNGI_YJL225C	YJL225C	YJL225C - Putative protein of unknown function; similarity to DNA helicases that are also encoded within subtelomeric Y' elements and induced in telomerase deficient survivors	1	0	0	0	0.047619048	0	0.05	0.0625
5051_OG5_132606_7 - FUNGI_YLL066C	YLL066C	YLL066C - Putative protein of unknown function with similarity to helicases; YLL066C is not an essential gene	1	0	0	0	0.047619048	0	0.05	0.0625
5052_OG5_132606_7 - FUNGI_YLL067C	YLL067C	YLL067C - Putative protein of unknown function with similarity to helicases	1	0	0	0	0.047619048	0	0.05	0.0625
5053_OG5_132606_7 - FUNGI_YLR462W	YLR462W	YLR462W - Putative protein of unknown function with similarity to helicases; YLR462W is within the telomere on the right arm of chromosome XII	1	0	0	0	0.047619048	0	0.05	0.0625
5054_OG5_132606_7 - FUNGI_YLR464W	YLR464W	YLR464W - Putative protein of unknown function; intron is predicted but not detected experimentally; YLR464W overlaps the verified gene YRF1-4/YLR466W and two dubious ORFs YLR463C and YLR465C	1	0	0	0	0.047619048	0	0.05	0.0625
5055_OG5_132606_7 - FUNGI_YML133C	YML133C	"YML133C - Putative protein of unknown function with similarity to helicases; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YML133C contains an intron"	1	0	0	0	0.047619048	0	0.05	0.0625
5056_OG5_132606_7 - FUNGI_YPR202W	YPR202W	YPR202W - Putative protein of unknown function with similarity to telomere-encoded helicases; YPR202W is not an essential gene; transcript is predicted to be spliced but there is no evidence that it is spliced in vivo	1	0	0	0	0.047619048	0	0.05	0.0625
5057_OG5_132606_7 - FUNGI_YPR203W	YPR203W	YPR203W - Putative protein of unknown function	1	0	0	0	0.047619048	0	0.05	0.0625
5058_OG5_132606_7 - FUNGI_YBL111C	YBL111C	YBL111C - Helicase-like protein encoded within the telomeric Y' element	1	0	0	0	0.047619048	0	0.05	0.0625
5059_OG5_132606_7 - FUNGI_YBL113C	YBL113C	YBL113C - Helicase-like protein encoded within the telomeric Y' element	1	0	0	0	0.047619048	0	0.05	0.0625
5060_OG5_132606_7 - FUNGI_YEL077C	YEL077C	YEL077C - Helicase-like protein encoded within the telomeric Y' element	1	0	0	0	0.047619048	0	0.05	0.0625
5061_OG5_132606_7 - FUNGI_YFL066C	YFL066C	YFL066C - Helicase-like protein encoded within the telomeric Y' element; induced by treatment with 8-methoxypsoralen and UVA irradiation	1	0	0	0	0.047619048	0	0.05	0.0625
5062_OG5_132606_7 - FUNGI_YHR218W	YHR218W	YHR218W - Helicase-like protein encoded within the telomeric Y' element	1	0	0	0	0.047619048	0	0.05	0.0625
5063_OG5_132606_7 - FUNGI_YOR396W	YOR396W	"YRF1-8 - One of several telomeric Y' element-encoded DNA helicases, known as Y'-Help1 (Y'-HELicase Protein 1)"	1	0	0	0	0.047619048	0	0.05	0.0625
5064_OG5_132606_7 - FUNGI_YNL339C	YNL339C	"YRF1-6 - Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p"	1	0	0	0	0.047619048	0	0.05	0.0625
5065_OG5_132606_7 - FUNGI_YDR545W	YDR545W	"YRF1-1 - Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p"	1	0	0	0	0.047619048	0	0.05	0.0625
5066_OG5_132606_7 - FUNGI_YER190W	YER190W	"YRF1-2 - Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p; induced by treatment with 8-methoxypsoralen and UVA irradiation"	1	0	0	0	0.047619048	0	0.05	0.0625
5067_OG5_132606_7 - FUNGI_YGR296W	YGR296W	"YRF1-3 - Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p"	1	0	0	0	0.047619048	0	0.05	0.0625
5068_OG5_132606_7 - FUNGI_YLR466W	YLR466W	"YRF1-4 - Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p"	1	0	0	0	0.047619048	0	0.05	0.0625
5069_OG5_132606_7 - FUNGI_YLR467W	YLR467W	"YRF1-5 - Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p"	1	0	0	0	0.047619048	0	0.05	0.0625
5070_OG5_132606_7 - FUNGI_YPL283C	YPL283C	"YRF1-7 - Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p"	1	0	0	0	0.047619048	0	0.05	0.0625
5071_OG5_132606_7 - FUNGI_YPR204W	YPR204W	YPR204W - Helicase-like protein encoded within the telomeric Y' element	1	0	0	0	0.047619048	0	0.05	0.0625
5072_OG5_160655_7 - FUNGI_YCR018C	YCR018C	SRD1 - Protein involved in the processing of pre-rRNA to mature rRNA; contains a C2/C2 zinc finger motif; srd1 mutation suppresses defects caused by the rrp1-1 mutation	1	0	0	0	0.047619048	0	0.05	0
5073_OG5_164278_7 - FUNGI_YOR237W	YOR237W	HES1 - Protein implicated in the regulation of ergosterol biosynthesis; one of a seven member gene family with a common essential function and non-essential unique functions; similar to human oxysterol binding protein (OSBP)	1	0	0	0	0.047619048	0	0.05	0
5074_OG5_188381_7 - FUNGI_YKL105C	YKL105C	YKL105C - Putative protein of unknown function	1	0	0	0	0.047619048	0	0.05	0.0625
5075_OG5_216953_7 - FUNGI_YFL056C	YFL056C	AAD6 - Putative aryl-alcohol dehydrogenase; involved in oxidative stress response; similar to P. chrysosporium aryl-alcohol dehydrogenase; expression induced in cells treated with the mycotoxin patulin	1	0	0	0.125	0	0	0.05	0
5076_OG5_149521_7 - FUNGI_YKL091C	YKL091C	"YKL091C - Putative homolog of Sec14p, which is a phosphatidylinositol/phosphatidylcholine transfer protein involved in lipid metabolism; localizes to the nucleus; contains a CRAL/TRIO domain and binds several lipids in a large-scale study"	1	0	0	0	0	0.5	0.05	0
5077_OG5_181405_7 - FUNGI_YDR540C	YDR540C	IRC4 - Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus	1	0	0.083333333	0	0	0	0.05	0
5078_OG5_132063_7 - FUNGI_YKL163W	YKL163W	"PIR3 - O-glycosylated covalently-bound cell wall protein required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway"	1	0	0	0	0	0	0.05	0.0625
5079_OG5_135526_7 - FUNGI_YGL261C	YGL261C	PAU11 - Putative protein of unknown function and member of the seripauperin multigene family encoded mainly in subtelomeric regions; mRNA expression appears to be regulated by SUT1 and UPC2	1	0	0	0	0	0	0.05	0
5080_OG5_135526_7 - FUNGI_YIL176C	YIL176C	"PAU14 - Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions; identical to Pau1p"	1	0	0	0	0	0	0.05	0
5081_OG5_135526_7 - FUNGI_YJR150C	YJR150C	"DAN1 - Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth"	1	0	0	0	0	0	0.05	0
5082_OG5_135526_7 - FUNGI_YBR301W	YBR301W	"PAU24 - Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; member of the seripauperin multigene family encoded mainly in subtelomeric regions; expressed under anaerobic conditions, completely repressed during aerobic growth"	1	0	0	0	0	0	0.05	0
5083_OG5_135526_7 - FUNGI_YAL068C	YAL068C	"PAU8 - Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions"	1	0	0	0	0	0	0.05	0
5084_OG5_135526_7 - FUNGI_YAR020C	YAR020C	"PAU7 - Member of the seripauperin multigene family, active during alcoholic fermentation, regulated by anaerobiosis, inhibited by oxygen, repressed by heme"	1	0	0	0	0	0	0.05	0
5085_OG5_135526_7 - FUNGI_YEL049W	YEL049W	"PAU2 - Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme"	1	0	0	0	0	0	0.05	0
5086_OG5_135526_7 - FUNGI_YFL020C	YFL020C	PAU5 - Member of the seripauperin multigene family encoded mainly in subtelomeric regions; induced during alcoholic fermentation; induced by low temperature and also by anaerobic conditions; negatively regulated by oxygen and repressed by heme	1	0	0	0	0	0	0.05	0
5087_OG5_135526_7 - FUNGI_YLR037C	YLR037C	"PAU23 - Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; member of the seripauperin multigene family encoded mainly in subtelomeric regions; expressed under anaerobic conditions, completely repressed during aerobic growth"	1	0	0	0	0	0	0.05	0
5088_OG5_135526_7 - FUNGI_YLR461W	YLR461W	"PAU4 - Member of the seripauperin multigene family encoded mainly in subtelomeric regions; active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme"	1	0	0	0	0	0	0.05	0
5089_OG5_135526_7 - FUNGI_YHL046C	YHL046C	"PAU13 - Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions; expression is induced after ethanol shock"	1	0	0	0	0	0	0.05	0
5090_OG5_135526_7 - FUNGI_YLL025W	YLL025W	"PAU17 - Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions; YLL025W is not an essential gene"	1	0	0	0	0	0	0.05	0
5091_OG5_135526_7 - FUNGI_YDR542W	YDR542W	"PAU10 - Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions"	1	0	0	0	0	0	0.05	0
5092_OG5_135526_7 - FUNGI_YGR294W	YGR294W	"PAU12 - Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions"	1	0	0	0	0	0	0.05	0
5093_OG5_135526_7 - FUNGI_YIR041W	YIR041W	"PAU15 - Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions"	1	0	0	0	0	0	0.05	0
5094_OG5_135526_7 - FUNGI_YKL224C	YKL224C	"PAU16 - Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions"	1	0	0	0	0	0	0.05	0
5095_OG5_135526_7 - FUNGI_YLL064C	YLL064C	"PAU18 - Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions; identical to Pau6p"	1	0	0	0	0	0	0.05	0
5096_OG5_135526_7 - FUNGI_YMR325W	YMR325W	"PAU19 - Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions"	1	0	0	0	0	0	0.05	0
5097_OG5_135526_7 - FUNGI_YOL161C	YOL161C	"PAU20 - Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions; expression induced by low temperature and also by anaerobic conditions; induced during alcoholic fermentation"	1	0	0	0	0	0	0.05	0
5098_OG5_135526_7 - FUNGI_YOR394W	YOR394W	"PAU21 - Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions; identical to Pau22p; encodes 2 proteins that are translated from 2 different start codons"	1	0	0	0	0	0	0.05	0
5099_OG5_135526_7 - FUNGI_YPL282C	YPL282C	"PAU22 - Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions; identical to Pau21p; encodes 2 proteins that are translated from 2 different start codons"	1	0	0	0	0	0	0.05	0
5100_OG5_135526_7 - FUNGI_YCR104W	YCR104W	"PAU3 - Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme"	1	0	0	0	0	0	0.05	0
5101_OG5_135526_7 - FUNGI_YJL223C	YJL223C	"PAU1 - Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme; identical to Pau14p"	1	0	0	0	0	0	0.05	0
5102_OG5_135526_7 - FUNGI_YNR076W	YNR076W	"PAU6 - Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme; identical to Pau18p"	1	0	0	0	0	0	0.05	0
5103_OG5_135909_7 - FUNGI_YHL042W	YHL042W	"YHL042W - Putative protein of unknown function; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins"	1	0	0	0	0	0	0.05	0
5104_OG5_135909_7 - FUNGI_YAR023C	YAR023C	"YAR023C - Putative integral membrane protein, member of DUP240 gene family"	1	0	0	0	0	0	0.05	0
5105_OG5_135909_7 - FUNGI_YAR029W	YAR029W	YAR029W - Member of DUP240 gene family but contains no transmembrane domains; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern	1	0	0	0	0	0	0.05	0
5106_OG5_135909_7 - FUNGI_YCR007C	YCR007C	"YCR007C - Putative integral membrane protein, member of DUP240 gene family; YCR007C is not an essential gene"	1	0	0	0	0	0	0.05	0
5107_OG5_135909_7 - FUNGI_YAR028W	YAR028W	"YAR028W - Putative integral membrane protein, member of DUP240 gene family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS"	1	0	0	0	0	0	0.05	0
5108_OG5_135909_7 - FUNGI_YHL044W	YHL044W	"YHL044W - Putative integral membrane protein, member of DUP240 gene family; green fluorescent protein (GFP)-fusion protein localizes to the plasma membrane in a punctate pattern"	1	0	0	0	0	0	0.05	0
5109_OG5_135909_7 - FUNGI_YGL263W	YGL263W	"COS12 - Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins"	1	0	0	0	0	0	0.05	0
5110_OG5_135909_7 - FUNGI_YGR295C	YGR295C	"COS6 - Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins"	1	0	0	0	0	0	0.05	0
5111_OG5_135909_7 - FUNGI_YNL336W	YNL336W	"COS1 - Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins"	1	0	0	0	0	0	0.05	0
5112_OG5_135909_7 - FUNGI_YHL043W	YHL043W	"ECM34 - Putative protein of unknown function; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins"	1	0	0	0	0	0	0.05	0
5113_OG5_135909_7 - FUNGI_YAR031W	YAR031W	"PRM9 - Pheromone-regulated protein with 3 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; member of DUP240 gene family"	1	0	0	0	0	0	0.05	0
5114_OG5_135909_7 - FUNGI_YNR075W	YNR075W	"COS10 - Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins"	1	0	0	0	0	0	0.05	0
5115_OG5_135909_7 - FUNGI_YAR027W	YAR027W	UIP3 - Putative integral membrane protein of unknown function; interacts with Ulp1p at the nuclear periphery; member of DUP240 gene family	1	0	0	0	0	0	0.05	0
5116_OG5_135909_7 - FUNGI_YGL053W	YGL053W	"PRM8 - Pheromone-regulated protein with 2 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; forms a complex with Prp9p in the ER; member of DUP240 gene family"	1	0	0	0	0	0	0.05	0
5117_OG5_135909_7 - FUNGI_YGL051W	YGL051W	"MST27 - Putative integral membrane protein, involved in vesicle formation; forms complex with Mst28p; member of DUP240 gene family; binds COPI and COPII vesicles"	1	0	0	0	0	0	0.05	0
5118_OG5_135909_7 - FUNGI_YML132W	YML132W	"COS3 - Protein involved in salt resistance; interacts with sodium:hydrogen antiporter Nha1p; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins"	1	0	0	0	0	0	0.05	0
5119_OG5_135909_7 - FUNGI_YHL048W	YHL048W	"COS8 - Nuclear membrane protein, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins; regulation suggests a potential role in the unfolded protein response"	1	0	0	0	0	0	0.05	0
5120_OG5_135909_7 - FUNGI_YBR302C	YBR302C	"COS2 - Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins"	1	0	0	0	0	0	0.05	0
5121_OG5_135909_7 - FUNGI_YDL248W	YDL248W	"COS7 - Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"	1	0	0	0	0	0	0.05	0
5122_OG5_135909_7 - FUNGI_YFL062W	YFL062W	"COS4 - Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins"	1	0	0	0	0	0	0.05	0
5123_OG5_135909_7 - FUNGI_YJR161C	YJR161C	"COS5 - Protein of unknown function, member the DUP380 subfamily of conserved, often subtelomerically-encoded proteins"	1	0	0	0	0	0	0.05	0
5124_OG5_135909_7 - FUNGI_YKL219W	YKL219W	"COS9 - Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins"	1	0	0	0	0	0	0.05	0
5125_OG5_135909_7 - FUNGI_YAR033W	YAR033W	"MST28 - Putative integral membrane protein, involved in vesicle formation; forms complex with Mst27p; member of DUP240 gene family; binds COPI and COPII vesicles"	1	0	0	0	0	0	0.05	0
5126_OG5_144511_7 - FUNGI_YNR048W	YNR048W	"YNR048W - Protein that interacts specifically in vivo with phospholipid translocase (flippase) Dnf3p; similar to Cdc50p, which is an essential interaction partner of the flippase Drs2p"	1	0	0	0	0	0	0.05	0.1875
5127_OG5_145177_7 - FUNGI_YEL061C	YEL061C	CIN8 - Kinesin motor protein involved in mitotic spindle assembly and chromosome segregation	1	0	0	0	0	0	0.05	0.1875
5128_OG5_148159_7 - FUNGI_YER018C	YER018C	"SPC25 - Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering"	1	0	0	0	0	0	0.05	0.1875
5129_OG5_155911_7 - FUNGI_YML061C	YML061C	PIF1 - DNA helicase; exists in a nuclear form that acts as a catalytic inhibitor of telomerase; and as a mitochondrial form involved in repair and recombination of mitochondrial DNA; mutations affect zinc and iron homeostasis	1	0	0	0	0	0	0.05	0.125
5130_OG5_156704_7 - FUNGI_YDR441C	YDR441C	"APT2 - Apparent pseudogene, not transcribed or translated under normal conditions; encodes a protein with similarity to adenine phosphoribosyltransferase, but artificially expressed protein exhibits no enzymatic activity"	1	0	0	0	0	0	0.05	0.125
5131_OG5_160604_7 - FUNGI_YBR148W	YBR148W	"YSW1 - Protein required for normal prospore membrane formation; interacts with Gip1p, which is the meiosis-specific regulatory subunit of the Glc7p protein phosphatase; expressed specifically in spores and localizes to the prospore membrane"	1	0	0	0	0	0	0.05	0.0625
5132_OG5_160982_7 - FUNGI_YDR515W	YDR515W	SLF1 - RNA binding protein that associates with polysomes; proposed to be involved in regulating mRNA translation; involved in the copper-dependent mineralization of copper sulfide complexes on cell surface in cells cultured in copper salts	1	0	0	0	0	0	0.05	0.0625
5133_OG5_174061_7 - FUNGI_YLR156W	YLR156W	YLR156W - Putative protein of unknown function; exhibits a two-hybrid interaction with Jsn1p in a large-scale analysis	1	0	0	0	0	0	0.05	0
5134_OG5_174061_7 - FUNGI_YLR157W-D	YLR157W-D	"YLR157W-D - Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"	1	0	0	0	0	0	0.05	0
5135_OG5_174061_7 - FUNGI_YLR157W-E	YLR157W-E	"YLR157W-E - Putative protein of unknown function identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; partially overlaps a Ty1 element"	1	0	0	0	0	0	0.05	0
5136_OG5_174061_7 - FUNGI_YLR159W	YLR159W	"YLR159W - Putative protein of unknown function; YLR156W, YLR159W, and YLR161W are three identical open reading frames encoded near the ribosomal DNA region of chromosome 12"	1	0	0	0	0	0	0.05	0
5137_OG5_174061_7 - FUNGI_YLR161W	YLR161W	"YLR161W - Putative protein of unknown function; YLR156W, YLR159W, and YLR161W are three identical open reading frames encoded near the ribosomal DNA region of chromosome 12"	1	0	0	0	0	0	0.05	0
5138_OG5_184986_7 - FUNGI_YIL014C-A	YIL014C-A	YIL014C-A - Putative protein of unknown function	1	0	0	0	0	0	0.05	0
5139_OG5_184986_7 - FUNGI_YIL102C	YIL102C	YIL102C - Putative protein of unknown function	1	0	0	0	0	0	0.05	0
5140_OG5_184986_7 - FUNGI_YEL073C	YEL073C	YEL073C - Putative protein of unknown function; located adjacent to ARS503 and the telomere on the left arm of chromosome V; regulated by inositol/choline	1	0	0	0	0	0	0.05	0
5141_OG5_184986_7 - FUNGI_YJR108W	YJR108W	"ABM1 - Protein of unknown function, required for normal microtubule organization"	1	0	0	0	0	0	0.05	0
5142_OG5_184987_7 - FUNGI_YLR154C-H	YLR154C-H	YLR154C-H - Putative protein of unknown function identified by fungal homology comparisons and RT-PCR; this ORF partially overlaps RND5-2	1	0	0	0	0	0	0.05	0
5143_OG5_184987_7 - FUNGI_YLR156C-A	YLR156C-A	YLR156C-A - Putative protein of unknown function identified by fungal homology comparisons and RT-PCR; this ORF partially overlaps RND5-3	1	0	0	0	0	0	0.05	0
5144_OG5_184987_7 - FUNGI_YLR157C-C	YLR157C-C	YLR157C-C - Putative protein of unknown function identified by fungal homology comparisons and RT-PCR; this ORF partially overlaps RND5-4	1	0	0	0	0	0	0.05	0
5145_OG5_184987_7 - FUNGI_YLR159C-A	YLR159C-A	YLR159C-A - Putative protein of unknown function identified by fungal homology comparisons and RT-PCR; this ORF partially overlaps RND5-5	1	0	0	0	0	0	0.05	0
5146_OG5_197567_7 - FUNGI_YBR210W	YBR210W	"ERV15 - Protein involved in export of proteins from the endoplasmic reticulum, has similarity to Erv14p"	1	0	0	0	0	0	0.05	0.0625
5147_OG5_206119_7 - FUNGI_YCR100C	YCR100C	YCR100C - Putative protein of unknown function	1	0	0	0	0	0	0.05	0
5148_OG5_206119_7 - FUNGI_YNR066C	YNR066C	YNR066C - Putative membrane-localized protein of unknown function	1	0	0	0	0	0	0.05	0
5149_OG5_206119_7 - FUNGI_YCR101C	YCR101C	YCR101C - Putative protein of unknown function; localizes to the membrane fraction; YCR101C is not an essential gene	1	0	0	0	0	0	0.05	0
5150_OG5_206120_7 - FUNGI_YIL060W	YIL060W	YIL060W - Putative protein of unknown function; mutant accumulates less glycogen than does wild type; null mutation results in a decrease in plasma membrane electron transport; YIL060W is not an essential gene	1	0	0	0	0	0	0.05	0
5151_OG5_206120_7 - FUNGI_YER138W-A	YER138W-A	YER138W-A - Putative protein of unknown function	1	0	0	0	0	0	0.05	0
5152_OG5_206120_7 - FUNGI_YOR192C-C	YOR192C-C	YOR192C-C - Putative protein of unknown function; identified by expression profiling and mass spectrometry	1	0	0	0	0	0	0.05	0
5153_OG5_206121_7 - FUNGI_YIL029C	YIL029C	YIL029C - Putative protein of unknown function; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)	1	0	0	0	0	0	0.05	0
5154_OG5_206121_7 - FUNGI_YPL257W	YPL257W	YPL257W - Putative protein of unknown function; homozygous diploid deletion strain exhibits low budding index; physically interacts with Hsp82p; YPL257W is not an essential gene	1	0	0	0	0	0	0.05	0
5155_OG5_206121_7 - FUNGI_YPR071W	YPR071W	YPR071W - Putative membrane protein; YPR071W is not an essential gene	1	0	0	0	0	0	0.05	0
5156_OG5_206123_7 - FUNGI_YMR322C	YMR322C	"SNO4 - Possible chaperone and cysteine protease, similar to bacterial Hsp31 and yeast Hsp31p, Hsp32p, and Hsp33p; DJ-1/ThiJ/PfpI superfamily member; predicted involvement in pyridoxine metabolism; induced by mild heat stress and copper deprivation"	1	0	0	0	0	0	0.05	0
5157_OG5_206123_7 - FUNGI_YPL280W	YPL280W	"HSP32 - Possible chaperone and cysteine protease with similarity to E. coli Hsp31 and S. cerevisiae Hsp31p, Hsp33p, and Sno4p; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease"	1	0	0	0	0	0	0.05	0
5158_OG5_206123_7 - FUNGI_YOR391C	YOR391C	"HSP33 - Possible chaperone and cysteine protease with similarity to E. coli Hsp31 and S. cerevisiae Hsp31p, Hsp32p, and Sno4p; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease"	1	0	0	0	0	0	0.05	0
5159_OG5_245580_7 - FUNGI_YAL064C-A	YAL064C-A	TDA8 - Putative protein of unknown function; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene	1	0	0	0	0	0	0.05	0
5160_OG5_245580_7 - FUNGI_YHR213W	YHR213W	"YHR213W - Possible pseudogene; has similarity to Flo1p, which is a lectin-like protein involved in flocculation"	1	0	0	0	0	0	0.05	0
5161_OG5_245581_7 - FUNGI_YAL067W-A	YAL067W-A	"YAL067W-A - Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"	1	0	0	0	0	0	0.05	0
5162_OG5_245581_7 - FUNGI_YNR075C-A	YNR075C-A	"YNR075C-A - Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"	1	0	0	0	0	0	0.05	0
5163_OG5_245582_7 - FUNGI_YAR064W	YAR064W	YAR064W - Putative protein of unknown function	1	0	0	0	0	0	0.05	0
5164_OG5_245582_7 - FUNGI_YHR213W-B	YHR213W-B	"YHR213W-B - Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"	1	0	0	0	0	0	0.05	0
5165_OG5_245583_7 - FUNGI_YAR066W	YAR066W	YAR066W - Putative GPI protein	1	0	0	0	0	0	0.05	0
5166_OG5_245583_7 - FUNGI_YHR214W	YHR214W	YHR214W - Putative protein of unknown function; predicted to be a glycosylphosphatidylinositol-modified (GPI) protein	1	0	0	0	0	0	0.05	0
5167_OG5_245584_7 - FUNGI_YCL068C	YCL068C	YCL068C - Putative protein of unknown function	1	0	0	0	0	0	0.05	0
5168_OG5_245584_7 - FUNGI_YCR038C	YCR038C	BUD5 - GTP/GDP exchange factor for Rsr1p (Bud1p) required for both axial and bipolar budding patterns; mutants exhibit random budding in all cell types	1	0	0	0	0	0	0.05	0
5169_OG5_245585_7 - FUNGI_YCR024C-A	YCR024C-A	"PMP1 - Small single-membrane span proteolipid that functions as a regulatory subunit of the plasma membrane H(+)-ATPase Pma1p, forms unique helix and positively charged cytoplasmic domain that is able to specifically segregate phosphatidylserines"	1	0	0	0	0	0	0.05	0
5170_OG5_245585_7 - FUNGI_YEL017C-A	YEL017C-A	PMP2 - Proteolipid associated with plasma membrane H(+)-ATPase (Pma1p); regulates plasma membrane H(+)-ATPase activity; nearly identical to PMP1	1	0	0	0	0	0	0.05	0
5171_OG5_245586_7 - FUNGI_YDR461W	YDR461W	"MFA1 - Mating pheromone a-factor, made by a cells; interacts with alpha cells to induce cell cycle arrest and other responses leading to mating; biogenesis involves C-terminal modification, N-terminal proteolysis, and export; also encoded by MFA2"	1	0	0	0	0	0	0.05	0
5172_OG5_245586_7 - FUNGI_YNL145W	YNL145W	"MFA2 - Mating pheromone a-factor, made by a cells; interacts with alpha cells to induce cell cycle arrest and other responses leading to mating; biogenesis involves C-terminal modification, N-terminal proteolysis, and export; also encoded by MFA1"	1	0	0	0	0	0	0.05	0
5173_OG5_245587_7 - FUNGI_YER188C-A	YER188C-A	YER188C-A - Putative protein of unknown function	1	0	0	0	0	0	0.05	0
5174_OG5_245587_7 - FUNGI_YOL166W-A	YOL166W-A	"YOL166W-A - Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"	1	0	0	0	0	0	0.05	0
5175_OG5_245588_7 - FUNGI_YER190C-B	YER190C-B	"YER190C-B - Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"	1	0	0	0	0	0	0.05	0
5176_OG5_245588_7 - FUNGI_YFL068W	YFL068W	YFL068W - Putative protein of unknown function	1	0	0	0	0	0	0.05	0
5177_OG5_245589_7 - FUNGI_YFL051C	YFL051C	YFL051C - Putative protein of unknown function; YFL051C is not an essential gene	1	0	0	0	0	0	0.05	0
5178_OG5_245589_7 - FUNGI_YHR212W-A	YHR212W-A	"YHR212W-A - Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"	1	0	0	0	0	0	0.05	0
5179_OG5_245590_7 - FUNGI_YOL165C	YOL165C	AAD15 - Putative aryl-alcohol dehydrogenase; similar to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role	1	0	0	0	0	0	0.05	0
5180_OG5_245590_7 - FUNGI_YFL057C	YFL057C	AAD16 - Putative aryl-alcohol dehydrogenase; similar to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role	1	0	0	0	0	0	0.05	0
5181_OG5_245592_7 - FUNGI_YHR053C	YHR053C	"CUP1-1 - Metallothionein, binds copper and mediates resistance to high concentrations of copper and cadmium; locus is variably amplified in different strains, with two copies, CUP1-1 and CUP1-2, in the genomic sequence reference strain S288C"	1	0	0	0	0	0	0.05	0
5182_OG5_245592_7 - FUNGI_YHR055C	YHR055C	"CUP1-2 - Metallothionein, binds copper and mediates resistance to high concentrations of copper and cadmium; locus is variably amplified in different strains, with two copies, CUP1-1 and CUP1-2, in the genomic sequence reference strain S288C"	1	0	0	0	0	0	0.05	0
5183_OG5_245593_7 - FUNGI_YHR054C	YHR054C	YHR054C - Putative protein of unknown function	1	0	0	0	0	0	0.05	0
5184_OG5_245593_7 - FUNGI_YHR056C	YHR056C	RSC30 - Component of the RSC chromatin remodeling complex; non-essential gene required for regulation of ribosomal protein genes and the cell wall/stress response; highly similar to Rsc3p; null mutants are osmosensitive	1	0	0	0	0	0	0.05	0
5185_OG5_245594_7 - FUNGI_YLR036C	YLR036C	YLR036C - Putative protein of unknown function predicted to have transmembrane domains; interacts with HSP90 by yeast two-hybrid analysis; YLR036C is not an essential protein	1	0	0	0	0	0	0.05	0
5186_OG5_245594_7 - FUNGI_YIL089W	YIL089W	YIL089W - Putative protein of unknown function	1	0	0	0	0	0	0.05	0
5187_OG5_245595_7 - FUNGI_YIR013C	YIR013C	GAT4 - Protein containing GATA family zinc finger motifs	1	0	0	0	0	0	0.05	0
5188_OG5_245595_7 - FUNGI_YLR013W	YLR013W	GAT3 - Protein containing GATA family zinc finger motifs	1	0	0	0	0	0	0.05	0
5189_OG5_245596_7 - FUNGI_YJL038C	YJL038C	LOH1 - Protein of unknown function with proposed roles in maintenance of genome integrity and also in spore wall assembly; induced during sporulation; repressed during vegetative growth by Sum1p and Hst1p; sequence similar to IRC1	1	0	0	0	0	0	0.05	0
5190_OG5_245596_7 - FUNGI_YJL037W	YJL037W	"IRC18 - Putative protein of unknown function; expression induced in respiratory-deficient cells and in carbon-limited chemostat cultures; similar to adjacent ORF, YJL038C; null mutant displays increased levels of spontaneous Rad52p foci"	1	0	0	0	0	0	0.05	0
5191_OG5_245597_7 - FUNGI_YJL043W	YJL043W	YJL043W - Putative protein of unknown function; YJL043W is a non-essential gene	1	0	0	0	0	0	0.05	0
5192_OG5_245597_7 - FUNGI_YKR015C	YKR015C	YKR015C - Putative protein of unknown function	1	0	0	0	0	0	0.05	0
5193_OG5_245598_7 - FUNGI_YLL066W-B	YLL066W-B	YLL066W-B - Putative protein of unknown function; overexpression causes a cell cycle delay or arrest	1	0	0	0	0	0	0.05	0
5194_OG5_245598_7 - FUNGI_YLR466C-B	YLR466C-B	"YLR466C-B - Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data"	1	0	0	0	0	0	0.05	0
5195_OG5_245599_7 - FUNGI_YPL250C	YPL250C	ICY2 - Protein of unknown function; mobilized into polysomes upon a shift from a fermentable to nonfermentable carbon source; potential Cdc28p substrate	1	0	0	0	0	0	0.05	0
5196_OG5_245599_7 - FUNGI_YMR195W	YMR195W	"ICY1 - Protein of unknown function, required for viability in rich media of cells lacking mitochondrial DNA; mutants have an invasive growth defect with elongated morphology; induced by amino acid starvation"	1	0	0	0	0	0	0.05	0
5197_OG5_245600_7 - FUNGI_YNL034W	YNL034W	YNL034W - Putative protein of unknown function; YNL034W is not an essential gene	1	0	0	0	0	0	0.05	0
5198_OG5_245600_7 - FUNGI_YNL018C	YNL018C	YNL018C - Putative protein of unknown function	1	0	0	0	0	0	0.05	0
5199_OG5_245601_7 - FUNGI_YNL019C	YNL019C	YNL019C - Putative protein of unknown function	1	0	0	0	0	0	0.05	0
5200_OG5_245601_7 - FUNGI_YNL033W	YNL033W	YNL033W - Putative protein of unknown function	1	0	0	0	0	0	0.05	0
5201_OG5_245602_7 - FUNGI_YOL013W-A	YOL013W-A	YOL013W-A - Putative protein of unknown function; identified by SAGE	1	0	0	0	0	0	0.05	0
5202_OG5_245602_7 - FUNGI_YOR072W-B	YOR072W-B	YOR072W-B - Putative protein of unknown function; identified by expression profiling and mass spectrometry	1	0	0	0	0	0	0.05	0
5203_OG5_128336_8 - MINOR CLUSTERS (FUNGI+NONCHORDATES+PLANTS)_YMR099C	YMR099C	"YMR099C - Glucose-6-phosphate 1-epimerase (hexose-6-phosphate mutarotase), likely involved in carbohydrate metabolism; GFP-fusion protein localizes to both the nucleus and cytoplasm and is induced in response to the DNA-damaging agent MMS"	1	0	0.138888889	1	0.714285714	0.071428571	0.95	0.25
5204_OG5_130336_8 - MINOR CLUSTERS (FUNGI+NONCHORDATES+PLANTS)_YJR142W	YJR142W	YJR142W - Putative protein of unknown function; GST fusion protein is a Dbf2-Mob1 phosphoylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition	1	0	0.083333333	1	0.619047619	0.142857143	1	0.0625
5205_OG5_129720_8 - MINOR CLUSTERS (FUNGI+NONCHORDATES+PLANTS)_YML074C	YML074C	FPR3 - Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase); FK506 binding protein; phosphorylated by casein kinase II (Cka1p-Cka2p-Ckb1p-Ckb2p) and dephosphorylated by Ptp1p	1	0	0.138888889	1	0.571428571	0.071428571	1	0.3125
5206_OG5_129720_8 - MINOR CLUSTERS (FUNGI+NONCHORDATES+PLANTS)_YLR449W	YLR449W	"FPR4 - Peptidyl-prolyl cis-trans isomerase (PPIase) (proline isomerase) localized to the nucleus; catalyzes isomerization of proline residues in histones H3 and H4, which affects lysine methylation of those histones"	1	0	0.138888889	1	0.571428571	0.071428571	1	0.3125
5207_OG5_130106_8 - MINOR CLUSTERS (FUNGI+NONCHORDATES+PLANTS)_YMR041C	YMR041C	"ARA2 - NAD-dependent arabinose dehydrogenase, involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase"	1	0	0.111111111	0.875	0.761904762	0.071428571	0.95	0
5208_OG5_129900_8 - MINOR CLUSTERS (FUNGI+NONCHORDATES+PLANTS)_YMR233W	YMR233W	"TRI1 - Non-essential sumoylated protein of unknown function with similarity to components of human SWI/SNF complex including SMRD3; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, nucleus and nucleolus"	1	0	0.027777778	0.875	0.761904762	0.071428571	0.95	0.3125
5209_OG5_129900_8 - MINOR CLUSTERS (FUNGI+NONCHORDATES+PLANTS)_YOR295W	YOR295W	"UAF30 - Subunit of UAF (upstream activation factor), which is an RNA polymerase I specific transcription stimulatory factor composed of Uaf30p, Rrn5p, Rrn9p, Rrn10p, histones H3 and H4; deletion decreases cellular growth rate"	1	0	0.027777778	0.875	0.761904762	0.071428571	0.95	0.3125
5210_OG5_127196_8 - MINOR CLUSTERS (FUNGI+NONCHORDATES+PLANTS)_YMR058W	YMR058W	"FET3 - Ferro-O2-oxidoreductase required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases"	1	0.0625	0.083333333	0.625	0.571428571	0.142857143	1	0.0625
5211_OG5_127196_8 - MINOR CLUSTERS (FUNGI+NONCHORDATES+PLANTS)_YFL041W	YFL041W	"FET5 - Multicopper oxidase, integral membrane protein with similarity to Fet3p; may have a role in iron transport"	1	0.0625	0.083333333	0.625	0.571428571	0.142857143	1	0.0625
5212_OG5_127315_8 - MINOR CLUSTERS (FUNGI+NONCHORDATES+PLANTS)_YJR107W	YJR107W	YJR107W - Putative protein of unknown function; has sequence or structural similarity to lipases	1	0	0.111111111	1	0.428571429	0	0.85	0.1875
5213_OG5_127062_8 - MINOR CLUSTERS (FUNGI+NONCHORDATES+PLANTS)_YDR541C	YDR541C	YDR541C - Putative dihydrokaempferol 4-reductase	1	0	0.083333333	0.75	0.523809524	0.071428571	0.95	0.3125
5214_OG5_127062_8 - MINOR CLUSTERS (FUNGI+NONCHORDATES+PLANTS)_YGL039W	YGL039W	YGL039W - Oxidoreductase shown to reduce carbonyl compounds to chiral alcohols	1	0	0.083333333	0.75	0.523809524	0.071428571	0.95	0.3125
5215_OG5_127062_8 - MINOR CLUSTERS (FUNGI+NONCHORDATES+PLANTS)_YOL151W	YOL151W	"GRE2 - 3-methylbutanal reductase and NADPH-dependent methylglyoxal reductase (D-lactaldehyde dehydrogenase); stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway"	1	0	0.083333333	0.75	0.523809524	0.071428571	0.95	0.3125
5216_OG5_127062_8 - MINOR CLUSTERS (FUNGI+NONCHORDATES+PLANTS)_YGL157W	YGL157W	"ARI1 - NADPH-dependent aldehyde reductase, utilizes aromatic and alophatic aldehyde substrates; member of the short-chain dehydrogenase/reductase superfamily"	1	0	0.083333333	0.75	0.523809524	0.071428571	0.95	0.3125
5217_OG5_128496_8 - MINOR CLUSTERS (FUNGI+NONCHORDATES+PLANTS)_YOL001W	YOL001W	"PHO80 - Cyclin, interacts with cyclin-dependent kinase Pho85p; regulates the response to nutrient levels and environmental conditions, including the response to phosphate limitation and stress-dependent calcium signaling"	1	0	0	0.75	0.285714286	0.071428571	1	0.6875
5218_OG5_128496_8 - MINOR CLUSTERS (FUNGI+NONCHORDATES+PLANTS)_YIL050W	YIL050W	"PCL7 - Pho85p cyclin of the Pho80p subfamily, forms a functional kinase complex with Pho85p which phosphorylates Mmr1p and is regulated by Pho81p; involved in glycogen metabolism, expression is cell-cycle regulated"	1	0	0	0.75	0.285714286	0.071428571	1	0.6875
5219_OG5_129983_8 - MINOR CLUSTERS (FUNGI+NONCHORDATES+PLANTS)_YOR198C	YOR198C	BFR1 - Component of mRNP complexes associated with polyribosomes; implicated in secretion and nuclear segregation; multicopy suppressor of BFA (Brefeldin A) sensitivity	1	0.0625	0	0.625	0.285714286	0	0.95	0.6875
5220_OG5_130214_8 - MINOR CLUSTERS (FUNGI+NONCHORDATES+PLANTS)_YDR276C	YDR276C	"PMP3 - Small plasma membrane protein related to a family of plant polypeptides that are overexpressed under high salt concentration or low temperature, not essential for viability, deletion causes hyperpolarization of the plasma membrane potential"	1	0	0.166666667	0.625	0.238095238	0	0.8	0.0625
5221_OG5_129706_8 - MINOR CLUSTERS (FUNGI+NONCHORDATES+PLANTS)_YOR288C	YOR288C	MPD1 - Member of the protein disulfide isomerase (PDI) family; interacts with and inhibits the chaperone activity of Cne1p; MPD1 overexpression in a pdi1 null mutant suppresses defects in Pdi1p functions such as carboxypeptidase Y maturation	1	0	0.027777778	0.5	0.285714286	0	1	0.375
5222_OG5_128620_8 - MINOR CLUSTERS (FUNGI+NONCHORDATES+PLANTS)_YJR051W	YJR051W	"OSM1 - Fumarate reductase, catalyzes the reduction of fumarate to succinate, required for the reoxidation of intracellular NADH under anaerobic conditions; mutations cause osmotic sensitivity"	1	0	0.055555556	0.5	0.238095238	0	0.95	0.25
5223_OG5_128620_8 - MINOR CLUSTERS (FUNGI+NONCHORDATES+PLANTS)_YEL047C	YEL047C	"YEL047C - Soluble fumarate reductase, required with isoenzyme Osm1p for anaerobic growth; may interact with ribosomes, based on co-purification experiments; authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies"	1	0	0.055555556	0.5	0.238095238	0	0.95	0.25
5224_OG5_131426_8 - MINOR CLUSTERS (FUNGI+NONCHORDATES+PLANTS)_YOL051W	YOL051W	GAL11 - Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; affects transcription by acting as target of activators and repressors	1	0.0625	0	0.5	0.476190476	0	0.6	0.0625
5225_OG5_128810_8 - MINOR CLUSTERS (FUNGI+NONCHORDATES+PLANTS)_YLR162W-A	YLR162W-A	RRT15 - Putative protein of unknown function identified by fungal homology comparisons and RT-PCR; identified in a screen for mutants with decreased levels of rDNA transcription	1	0	0	0.375	0.333333333	0.142857143	0.15	0.1875
5226_OG5_134379_8 - MINOR CLUSTERS (FUNGI+NONCHORDATES+PLANTS)_YPR192W	YPR192W	"AQY1 - Spore-specific water channel that mediates the transport of water across cell membranes, developmentally controlled; may play a role in spore maturation, probably by allowing water outflow, may be involved in freeze tolerance"	1	0	0	0.5	0.238095238	0.071428571	0.1	0.0625
5227_OG5_127894_8 - MINOR CLUSTERS (FUNGI+CHORDATES+PLANTS)_YOR334W	YOR334W	"MRS2 - Mitochondrial inner membrane Mg(2+) channel, required for maintenance of intramitochondrial Mg(2+) concentrations at the correct level to support splicing of group II introns"	1	0	0.027777778	1	0.142857143	0.928571429	1	0.375
5228_OG5_127894_8 - MINOR CLUSTERS (FUNGI+CHORDATES+PLANTS)_YPL060W	YPL060W	"MFM1 - Mitochondrial inner membrane magnesium transporter, involved in maintenance of mitochondrial magnesium concentrations and membrane potential; indirectly affects splicing of group II introns; functionally and structurally related to Mrs2p"	1	0	0.027777778	1	0.142857143	0.928571429	1	0.375
5229_OG5_130285_8 - MINOR CLUSTERS (FUNGI+CHORDATES+PLANTS)_YHR016C	YHR016C	YSC84 - Actin-binding protein involved in bundling of actin filaments and endocytosis of actin cortical patches; activity stimulated by Las17p; contains SH3 domain similar to Rvs167p	1	0	0.055555556	0.875	0.19047619	0.928571429	1	0.0625
5230_OG5_130285_8 - MINOR CLUSTERS (FUNGI+CHORDATES+PLANTS)_YFR024C-A	YFR024C-A	"LSB3 - Protein containing a C-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization"	1	0	0.055555556	0.875	0.19047619	0.928571429	1	0.0625
5231_OG5_130895_8 - MINOR CLUSTERS (FUNGI+CHORDATES+PLANTS)_YLR050C	YLR050C	YLR050C - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YLR050C is not an essential gene	1	0	0	1	0.142857143	0.928571429	0.95	0
5232_OG5_129832_8 - MINOR CLUSTERS (FUNGI+CHORDATES+PLANTS)_YGR175C	YGR175C	"ERG1 - Squalene epoxidase, catalyzes the epoxidation of squalene to 2,3-oxidosqualene; plays an essential role in the ergosterol-biosynthesis pathway and is the specific target of the antifungal drug terbinafine"	1	0	0	0.875	0.142857143	0.928571429	1	0.1875
5233_OG5_129914_8 - MINOR CLUSTERS (FUNGI+CHORDATES+PLANTS)_YFL046W	YFL046W	"FMP32 - Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"	1	0	0	0.875	0.095238095	0.928571429	1	0.0625
5234_OG5_131622_8 - MINOR CLUSTERS (FUNGI+CHORDATES+PLANTS)_YER044C	YER044C	"ERG28 - Endoplasmic reticulum membrane protein, may facilitate protein-protein interactions between the Erg26p dehydrogenase and the Erg27p 3-ketoreductase and/or tether these enzymes to the ER, also interacts with Erg6p"	1	0	0	0.75	0.142857143	0.928571429	1	0
5235_OG5_129574_8 - MINOR CLUSTERS (FUNGI+CHORDATES+PLANTS)_YJR074W	YJR074W	"MOG1 - Conserved nuclear protein that interacts with GTP-Gsp1p, which is a Ran homolog of the Ras GTPase family, and stimulates nucleotide release, involved in nuclear protein import, nucleotide release is inhibited by Yrb1p"	1	0	0	0.875	0.142857143	0.785714286	1	0.625
5236_OG5_129223_8 - MINOR CLUSTERS (FUNGI+CHORDATES+PLANTS)_YML072C	YML072C	"TCB3 - Lipid-binding protein, localized to the bud via specific mRNA transport; non-tagged protein detected in a phosphorylated state in mitochondria; GFP-fusion protein localizes to the cell periphery; C-termini of Tcb1p, Tcb2p and Tcb3p interact"	1	0	0	0.625	0.19047619	0.785714286	1	0.1875
5237_OG5_129223_8 - MINOR CLUSTERS (FUNGI+CHORDATES+PLANTS)_YNL087W	YNL087W	TCB2 - Bud-specific protein with a potential role in membrane trafficking; GFP-fusion protein migrates from the cell surface to intracellular vesicles near vacuole; contains 3 calcium and lipid binding domains; mRNA is targeted to the bud	1	0	0	0.625	0.19047619	0.785714286	1	0.1875
5238_OG5_129223_8 - MINOR CLUSTERS (FUNGI+CHORDATES+PLANTS)_YOR086C	YOR086C	"TCB1 - Lipid-binding protein containing three calcium and lipid binding domains; non-tagged protein localizes to mitochondria and GFP-fusion protein localizes to the cell periphery; C-termini of Tcb1p, Tcb2p and Tcb3p interact"	1	0	0	0.625	0.19047619	0.785714286	1	0.1875
5239_OG5_128249_8 - MINOR CLUSTERS (FUNGI+CHORDATES+PLANTS)_YEL060C	YEL060C	"PRB1 - Vacuolar proteinase B (yscB), a serine protease of the subtilisin family; involved in protein degradation in the vacuole and required for full protein degradation during sporulation; activity inhibited by Pbi2p"	1	0.125	0.138888889	0.625	0.047619048	0.642857143	1	0.375
5240_OG5_128249_8 - MINOR CLUSTERS (FUNGI+CHORDATES+PLANTS)_YOR003W	YOR003W	YSP3 - Putative precursor to the subtilisin-like protease III	1	0.125	0.138888889	0.625	0.047619048	0.642857143	1	0.375
5241_OG5_131328_8 - MINOR CLUSTERS (FUNGI+CHORDATES+PLANTS)_YDR257C	YDR257C	RKM4 - Ribosomal lysine methyltransferase specific for monomethylation of Rpl42ap and Rpl42bp (lysine 55); nuclear SET-domain containing protein	1	0	0	0.5	0.19047619	0.857142857	1	0.0625
5242_OG5_130887_8 - MINOR CLUSTERS (FUNGI+CHORDATES+PLANTS)_YDR071C	YDR071C	"PAA1 - Polyamine acetyltransferase; acetylates polyamines (e.g. putrescine, spermidine, spermine) and also aralkylamines (e.g. tryptamine, phenylethylamine); may be involved in transcription and/or DNA replication"	1	0	0.083333333	0.5	0.047619048	0.928571429	0.9	0
5243_OG5_129624_8 - MINOR CLUSTERS (FUNGI+CHORDATES+PLANTS)_YAL049C	YAL049C	AIM2 - Cytoplasmic protein involved in mitochondrial function or organization; null mutant displays reduced frequency of mitochondrial genome loss; potential Hsp82p interactor	1	0	0	0.5	0.095238095	0.857142857	0.95	0.125
5244_OG5_131899_8 - MINOR CLUSTERS (FUNGI+CHORDATES+PLANTS)_YIL001W	YIL001W	YIL001W - Putative protein of unknown function; contains a BTB/POZ domain which generally function in protein interactions; deletion slightly improved competitive fitness in rich media; GFP-tagged protein is localized to the cytoplasm	1	0	0	0.5	0.19047619	1	0.7	0.0625
5245_OG5_129380_8 - MINOR CLUSTERS (FUNGI+CHORDATES+PLANTS)_YOR257W	YOR257W	"CDC31 - Calcium-binding component of the spindle pole body (SPB) half-bridge, required for SPB duplication in mitosis and meiosis II; homolog of mammalian centrin; binds multiubiquitinated proteins and is involved in proteasomal protein degradation"	1	0	0	0.375	0.142857143	0.857142857	1	0.875
5246_OG5_132938_8 - MINOR CLUSTERS (FUNGI+CHORDATES+PLANTS)_YLR397C	YLR397C	"AFG2 - ATPase of the CDC48/PAS1/SEC18 (AAA) family, forms a hexameric complex; is essential for pre-60S maturation and release of several preribosome maturation factors; may be involved in degradation of aberrant mRNAs"	1	0	0	0.75	0.142857143	0.785714286	0.6	0.0625
5247_OG5_131398_8 - MINOR CLUSTERS (FUNGI+CHORDATES+PLANTS)_YDR379C-A	YDR379C-A	YDR379C-A - Protein involved in the assembly of the mitochondrial succinate dehydrogenase complex; mutations in human ortholog SDHAF1 are associated with infantile leukoencephalopathy	1	0	0	0.875	0.095238095	0.571428571	0.65	0.25
5248_OG5_130288_8 - MINOR CLUSTERS (FUNGI+CHORDATES+PLANTS)_YJR078W	YJR078W	"BNA2 - Putative tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase, required for de novo biosynthesis of NAD from tryptophan via kynurenine; interacts genetically with telomere capping gene CDC13; regulated by Hst1p and Aftp"	1	0	0	0.25	0.142857143	0.928571429	0.85	0.0625
5249_OG5_133005_8 - MINOR CLUSTERS (FUNGI+CHORDATES+PLANTS)_YPL089C	YPL089C	"RLM1 - MADS-box transcription factor, component of the protein kinase C-mediated MAP kinase pathway involved in the maintenance of cell integrity; phosphorylated and activated by the MAP-kinase Slt2p"	1	0	0	0.25	0.047619048	0.857142857	0.7	0.0625
5250_OG5_131684_8 - MINOR CLUSTERS (FUNGI+CHORDATES+PLANTS)_YLL053C	YLL053C	YLL053C - Putative protein; in the Sigma 1278B strain background YLL053C is contiguous with AQY2 which encodes an aquaporin	1	0	0	0.5	0.142857143	0.785714286	0.2	0
5251_OG5_133623_8 - MINOR CLUSTERS (FUNGI+CHORDATES+PLANTS)_YER075C	YER075C	PTP3 - Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; localized to the cytoplasm	1	0	0	0.25	0.047619048	0.285714286	1	0
5252_OG5_135991_8 - MINOR CLUSTERS (FUNGI+CHORDATES+PLANTS)_YGR238C	YGR238C	"KEL2 - Protein that functions in a complex with Kel1p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate"	1	0	0	0.25	0.142857143	1	0.05	0.0625
5253_OG5_130601_8 - MINOR CLUSTERS (FUNGI+NONCHORDATES)_YOL098C	YOL098C	YOL098C - Putative metalloprotease	1	0	0	0	0.761904762	0.071428571	1	0.4375
5254_OG5_132646_8 - MINOR CLUSTERS (FUNGI+NONCHORDATES)_YDL213C	YDL213C	NOP6 - rRNA-binding protein required for 40S ribosomal subunit biogenesis; contains an RNA recognition motif (RRM) and has similarity to hydrophilins; NOP6 may be a fungal-specific gene as no homologs have been yet identified in higher eukaryotes	1	0	0	0.125	0.333333333	0.071428571	1	0.1875
5255_OG5_133660_8 - MINOR CLUSTERS (FUNGI+NONCHORDATES)_YIL108W	YIL108W	YIL108W - Putative metalloprotease	1	0	0.027777778	0	0.476190476	0	0.8	0.125
5256_OG5_135088_8 - MINOR CLUSTERS (FUNGI+NONCHORDATES)_YLL021W	YLL021W	"SPA2 - Component of the polarisome, which functions in actin cytoskeletal organization during polarized growth; acts as a scaffold for Mkk1p and Mpk1p cell wall integrity signaling components; potential Cdc28p substrate"	1	0	0	0.125	0.095238095	0.071428571	1	0
5257_OG5_135141_8 - MINOR CLUSTERS (FUNGI+NONCHORDATES)_YOR296W	YOR296W	YOR296W - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; expressed during copper starvation; YOR296W is not an essential gene	1	0	0	0.125	0.095238095	0.071428571	1	0
5258_OG5_135309_8 - MINOR CLUSTERS (FUNGI+NONCHORDATES)_YER058W	YER058W	PET117 - Protein required for assembly of cytochrome c oxidase	1	0	0	0	0.333333333	0.142857143	0.7	0
5259_OG5_135922_8 - MINOR CLUSTERS (FUNGI+NONCHORDATES)_YCR065W	YCR065W	"HCM1 - Forkhead transcription factor that drives S-phase specific expression of genes involved in chromosome segregation, spindle dynamics, and budding; suppressor of calmodulin mutants with specific SPB assembly defects; telomere maintenance role"	1	0	0	0	0.571428571	0.142857143	0.2	0.0625
5260_OG5_136014_8 - MINOR CLUSTERS (FUNGI+NONCHORDATES)_YDL223C	YDL223C	"HBT1 - Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis"	1	0	0	0.125	0.285714286	0.071428571	0.05	0.0625
5261_OG5_152278_8 - MINOR CLUSTERS (FUNGI+NONCHORDATES)_YGL104C	YGL104C	VPS73 - Mitochondrial protein; mutation affects vacuolar protein sorting; putative transporter; member of the sugar porter family	1	0	0	0	0.333333333	0	0.05	0
5262_OG5_152278_8 - MINOR CLUSTERS (FUNGI+NONCHORDATES)_YNL318C	YNL318C	"HXT14 - Protein with similarity to hexose transporter family members, expression is induced in low glucose and repressed in high glucose; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"	1	0	0	0	0.333333333	0	0.05	0
5263_OG5_155323_8 - MINOR CLUSTERS (FUNGI+NONCHORDATES)_YDR504C	YDR504C	SPG3 - Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources	1	0	0	0	0.238095238	0.071428571	0.05	0
5264_OG5_158434_8 - MINOR CLUSTERS (FUNGI+NONCHORDATES)_YJL164C	YJL164C	TPK1 - cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; partially redundant with Tpk2p and Tpk3p	1	0	0	0	0.285714286	0	0.05	0
5265_OG5_130138_8 - MINOR CLUSTERS (FUNGI+CHORDATES)_YGR070W	YGR070W	"ROM1 - GDP/GTP exchange protein (GEP) for Rho1p; mutations are synthetically lethal with mutations in rom2, which also encodes a GEP"	1	0	0	0	0.19047619	1	1	0
5266_OG5_130138_8 - MINOR CLUSTERS (FUNGI+CHORDATES)_YLR371W	YLR371W	"ROM2 - GDP/GTP exchange factor (GEF) for Rho1p and Rho2p; mutations are synthetically lethal with mutations in rom1, which also encodes a GEF"	1	0	0	0	0.19047619	1	1	0
5267_OG5_130720_8 - MINOR CLUSTERS (FUNGI+CHORDATES)_YCR002C	YCR002C	"CDC10 - Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM"	1	0	0	0	0.095238095	1	1	0
5268_OG5_132307_8 - MINOR CLUSTERS (FUNGI+CHORDATES)_YLR100W	YLR100W	"ERG27 - 3-keto sterol reductase, catalyzes the last of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants are sterol auxotrophs"	1	0	0	0	0.047619048	0.928571429	1	0
5269_OG5_129831_8 - MINOR CLUSTERS (FUNGI+CHORDATES)_YMR221C	YMR221C	"YMR221C - Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; physical interaction with Atg27p suggests a possible role in autophagy"	1	0	0	0.125	0.095238095	1	0.7	0.3125
5270_OG5_132928_8 - MINOR CLUSTERS (FUNGI+CHORDATES)_YKL047W	YKL047W	"YKL047W - Putative protein of unknown function, predicted to be palmitoylated; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm"	1	0	0	0	0.19047619	1	0.7	0
5271_OG5_132397_8 - MINOR CLUSTERS (FUNGI+CHORDATES)_YIL042C	YIL042C	PKP1 - Mitochondrial protein kinase involved in negative regulation of pyruvate dehydrogenase complex activity by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp2p and phosphatases Ptc5p and Ptc6p	1	0	0.027777778	0	0.19047619	0.857142857	0.8	0.125
5272_OG5_132900_8 - MINOR CLUSTERS (FUNGI+CHORDATES)_YCR017C	YCR017C	CWH43 - Putative sensor/transporter protein involved in cell wall biogenesis; contains 14-16 transmembrane segments and several putative glycosylation and phosphorylation sites; null mutation is synthetically lethal with pkc1 deletion	1	0	0	0.125	0.142857143	0.642857143	0.95	0
5273_OG5_133340_8 - MINOR CLUSTERS (FUNGI+CHORDATES)_YHR133C	YHR133C	"NSG1 - Protein involved in regulation of sterol biosynthesis; specifically stabilizes Hmg2p, one of two HMG-CoA isoenzymes that catalyze the rate-limiting step in sterol biosynthesis; homolog of mammalian INSIG proteins"	1	0	0	0.125	0.142857143	0.714285714	0.7	0
5274_OG5_133340_8 - MINOR CLUSTERS (FUNGI+CHORDATES)_YNL156C	YNL156C	"NSG2 - Protein involved in regulation of sterol biosynthesis; specifically stabilizes Hmg2p, one of two HMG-CoA isoenzymes that catalyze the rate-limiting step in sterol biosynthesis; homolog of mammalian INSIG proteins"	1	0	0	0.125	0.142857143	0.714285714	0.7	0
5275_OG5_134697_8 - MINOR CLUSTERS (FUNGI+CHORDATES)_YKL005C	YKL005C	"BYE1 - Negative regulator of transcription elongation, contains a TFIIS-like domain and a PHD finger, multicopy suppressor of temperature-sensitive ess1 mutations, probably binds RNA polymerase II large subunit"	1	0	0	0.125	0.095238095	0.857142857	0.5	0
5276_OG5_132937_8 - MINOR CLUSTERS (FUNGI+CHORDATES)_YNL321W	YNL321W	VNX1 - Calcium/H+ antiporter localized to the endoplasmic reticulum membrane; member of the calcium exchanger (CAX) family; potential Cdc28p substrate	1	0	0	0.125	0.047619048	0.357142857	1	0.0625
5277_OG5_133689_8 - MINOR CLUSTERS (FUNGI+CHORDATES)_YLR218C	YLR218C	COA4 - Twin Cx(9)C protein involved in cytochrome c oxidase assembly or stability; localizes to the mitochondrial intermembrane space via the Mia40p-Erv1p system; interacts genetically with CYC1 and with cytochrome c oxidase assembly factors	1	0	0	0	0.19047619	0.785714286	0.55	0.0625
5278_OG5_133579_8 - MINOR CLUSTERS (FUNGI+CHORDATES)_YKR074W	YKR074W	AIM29 - Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm; YKR074W is not an essential gene; null mutant displays elevated frequency of mitochondrial genome loss	1	0	0	0	0.142857143	0.714285714	0.65	0.125
5279_OG5_134255_8 - MINOR CLUSTERS (FUNGI+CHORDATES)_YDR286C	YDR286C	YDR286C - Putative protein of unknown function; predicted to have thiol-disulfide oxidoreductase active site	1	0	0.111111111	0	0.142857143	0.571428571	0.6	0
5280_OG5_133763_8 - MINOR CLUSTERS (FUNGI+CHORDATES)_YDR379W	YDR379W	"RGA2 - GTPase-activating protein for the polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth; regulated by Pho85p and Cdc28p"	1	0	0	0	0.095238095	0.285714286	1	0
5281_OG5_133763_8 - MINOR CLUSTERS (FUNGI+CHORDATES)_YOR127W	YOR127W	"RGA1 - GTPase-activating protein for the polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth"	1	0	0	0	0.095238095	0.285714286	1	0
5282_OG5_134169_8 - MINOR CLUSTERS (FUNGI+CHORDATES)_YHR205W	YHR205W	"SCH9 - Protein kinase involved in transcriptional activation of osmostress-responsive genes; regulates G1 progression, cAPK activity, nitrogen activation of the FGM pathway; involved in life span regulation; homologous to mammalian Akt/PKB"	1	0	0	0	0.047619048	0.214285714	1	0
5283_OG5_139634_8 - MINOR CLUSTERS (FUNGI+CHORDATES)_YDR031W	YDR031W	"MIC14 - Mitochondrial intermembrane space protein, required for normal oxygen consumption; contains twin cysteine-x9-cysteine motifs"	1	0	0	0	0.047619048	0.642857143	0.25	0
5284_OG5_140217_8 - MINOR CLUSTERS (FUNGI+CHORDATES)_YPR186C	YPR186C	PZF1 - Transcription factor IIIA (TFIIIA); essential DNA binding protein required for transcription of 5S rRNA by RNA polymerase III; not involved in transcription of other RNAP III genes; nine conserved zinc fingers; may also bind 5S rRNA	1	0	0	0	0	0.857142857	0.05	0
5285_OG5_142644_8 - MINOR CLUSTERS (FUNGI+CHORDATES)_YOR156C	YOR156C	"NFI1 - SUMO ligase, catalyzes the covalent attachment of SUMO (Smt3p) to proteins; involved in maintenance of proper telomere length"	1	0	0	0	0	0.857142857	0.05	0
5286_OG5_127503_8 - MINOR CLUSTERS (FUNGI+NONCHORDATES+PLANTS+BACTERIA)_YNL036W	YNL036W	NCE103 - Carbonic anhydrase; poorly transcribed under aerobic conditions and at an undetectable level under anaerobic conditions; involved in non-classical protein export pathway	1	0.0625	0.527777778	0.75	0.666666667	0	1	0.1875
5287_OG5_129327_8 - MINOR CLUSTERS (FUNGI+NONCHORDATES+PLANTS+BACTERIA)_YBR126C	YBR126C	"TPS1 - Synthase subunit of trehalose-6-phosphate synthase/phosphatase complex, which synthesizes the storage carbohydrate trehalose; also found in a monomeric form; expression is induced by the stress response and repressed by the Ras-cAMP pathway"	1	0.0625	0.277777778	1	0.666666667	0	1	0.125
5288_OG5_129035_8 - MINOR CLUSTERS (FUNGI+NONCHORDATES+PLANTS+BACTERIA)_YKL027W	YKL027W	"YKL027W - Protein of unknown function, localized to the mitochondrial outer membrane"	1	0	0.472222222	1	0.285714286	0	1	0.375
5289_OG5_129350_8 - MINOR CLUSTERS (FUNGI+NONCHORDATES+PLANTS+BACTERIA)_YMR251W	YMR251W	GTO3 - Omega class glutathione transferase; putative cytosolic localization	1	0.125	0.222222222	1	0.285714286	0.071428571	0.95	0.0625
5290_OG5_129350_8 - MINOR CLUSTERS (FUNGI+NONCHORDATES+PLANTS+BACTERIA)_YKR076W	YKR076W	ECM4 - Omega class glutathione transferase; not essential; similar to Ygr154cp; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	1	0.125	0.222222222	1	0.285714286	0.071428571	0.95	0.0625
5291_OG5_128808_8 - MINOR CLUSTERS (FUNGI+NONCHORDATES+PLANTS+BACTERIA)_YJL055W	YJL055W	"YJL055W - Putative protein of unknown function, proposed to be involved in the metabolism of purine and pyrimidine base analogues; deletion mutants are sensitive to HAP and AHA; overexpression confers resistance to 5-FOA and 5-FU"	1	0.0625	0.361111111	1	0.238095238	0	0.85	0.0625
5292_OG5_128435_8 - MINOR CLUSTERS (FUNGI+NONCHORDATES+PLANTS+BACTERIA)_YKR097W	YKR097W	"PCK1 - Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol"	1	0.0625	0.388888889	0.75	0.285714286	0	0.95	0.625
5293_OG5_129399_8 - MINOR CLUSTERS (FUNGI+NONCHORDATES+PLANTS+BACTERIA)_YJR149W	YJR149W	YJR149W - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	1	0.0625	0.361111111	0.75	0.238095238	0	0.85	0.1875
5294_OG5_131390_8 - MINOR CLUSTERS (FUNGI+NONCHORDATES+PLANTS+BACTERIA)_YLR011W	YLR011W	"LOT6 - FMN-dependent NAD(P)H:quinone reductase, may be involved in quinone detoxification; expression elevated at low temperature; sequesters the Cin5p transcription factor in the cytoplasm in complex with the proteasome under reducing conditions"	1	0.0625	0.416666667	0.375	0.238095238	0.071428571	0.5	0.125
5295_OG5_128757_8 - MINOR CLUSTERS (FUNGI+CHORDATES+PLANTS+BACTERIA)_YHR189W	YHR189W	"PTH1 - One of two (see also PTH2) mitochondrially-localized peptidyl-tRNA hydrolases; dispensable for respiratory growth on rich medium, but required for respiratory growth on minimal medium"	1	0	1	1	0.19047619	0.857142857	0.8	0.0625
5296_OG5_128662_8 - MINOR CLUSTERS (FUNGI+CHORDATES+PLANTS+BACTERIA)_YCR053W	YCR053W	"THR4 - Threonine synthase, conserved protein that catalyzes formation of threonine from O-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway"	1	0	0.527777778	0.375	0.142857143	1	1	0.375
5297_OG5_129049_8 - MINOR CLUSTERS (FUNGI+CHORDATES+PLANTS+BACTERIA)_YJR019C	YJR019C	TES1 - Peroxisomal acyl-CoA thioesterase likely to be involved in fatty acid oxidation rather than fatty acid synthesis; conserved protein also found in human peroxisomes; TES1 mRNA levels increase during growth on fatty acids	1	0	0.277777778	0.5	0.19047619	0.857142857	0.95	0.1875
5298_OG5_129511_8 - MINOR CLUSTERS (FUNGI+PLANTS+BACTERIA)_YBR256C	YBR256C	RIB5 - Riboflavin synthase; catalyzes the last step of the riboflavin biosynthesis pathway	1	0.1875	0.888888889	1	0.142857143	0	1	0.0625
5299_OG5_129287_8 - MINOR CLUSTERS (FUNGI+PLANTS+BACTERIA)_YHR147C	YHR147C	MRPL6 - Mitochondrial ribosomal protein of the large subunit	1	0	1	1	0.142857143	0.071428571	1	0
5300_OG5_129694_8 - MINOR CLUSTERS (FUNGI+PLANTS+BACTERIA)_YDR408C	YDR408C	"ADE8 - Phosphoribosyl-glycinamide transformylase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway"	1	0.125	0.888888889	1	0.142857143	0	0.9	0
5301_OG5_129569_8 - MINOR CLUSTERS (FUNGI+PLANTS+BACTERIA)_YIL145C	YIL145C	"PAN6 - Pantothenate synthase, also known as pantoate-beta-alanine ligase, required for pantothenic acid biosynthesis, deletion causes pantothenic acid auxotrophy, homologous to E. coli panC"	1	0	0.805555556	1	0.238095238	0	1	0.1875
5302_OG5_129979_8 - MINOR CLUSTERS (FUNGI+PLANTS+BACTERIA)_YGR286C	YGR286C	"BIO2 - Biotin synthase, catalyzes the conversion of dethiobiotin to biotin, which is the last step of the biotin biosynthesis pathway; complements E. coli bioB mutant"	1	0.1875	0.75	1	0.142857143	0	0.85	0.0625
5303_OG5_129846_8 - MINOR CLUSTERS (FUNGI+PLANTS+BACTERIA)_YCL018W	YCL018W	"LEU2 - Beta-isopropylmalate dehydrogenase (IMDH), catalyzes the third step in the leucine biosynthesis pathway"	1	0.0625	0.666666667	1	0.142857143	0	1	0.0625
5304_OG5_127964_8 - MINOR CLUSTERS (FUNGI+PLANTS+BACTERIA)_YCR004C	YCR004C	"YCP4 - Protein of unknown function, has sequence and structural similarity to flavodoxins; predicted to be palmitoylated; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"	1	0.1875	0.472222222	1	0.142857143	0	0.95	0.0625
5305_OG5_127964_8 - MINOR CLUSTERS (FUNGI+PLANTS+BACTERIA)_YDR032C	YDR032C	"PST2 - Protein with similarity to members of a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"	1	0.1875	0.472222222	1	0.142857143	0	0.95	0.0625
5306_OG5_128969_8 - MINOR CLUSTERS (FUNGI+PLANTS+BACTERIA)_YMR188C	YMR188C	MRPS17 - Mitochondrial ribosomal protein of the small subunit	1	0	1	0.875	0.19047619	0	0.65	0.25
5307_OG5_127253_8 - MINOR CLUSTERS (FUNGI+PLANTS+BACTERIA)_YPL036W	YPL036W	"PMA2 - Plasma membrane H+-ATPase, isoform of Pma1p, involved in pumping protons out of the cell; regulator of cytoplasmic pH and plasma membrane potential"	1	0.1875	0.361111111	1	0.142857143	0	1	0.375
5308_OG5_127253_8 - MINOR CLUSTERS (FUNGI+PLANTS+BACTERIA)_YGL008C	YGL008C	"PMA1 - Plasma membrane H+-ATPase, pumps protons out of the cell; major regulator of cytoplasmic pH and plasma membrane potential; P2-type ATPase; Hsp30p plays a role in Pma1p regulation; interactions with Std1p appear to propagate [GAR+]"	1	0.1875	0.361111111	1	0.142857143	0	1	0.375
5309_OG5_129378_8 - MINOR CLUSTERS (FUNGI+PLANTS+BACTERIA)_YOR283W	YOR283W	"YOR283W - Phosphatase with a broad substrate specificity and some similarity to GPM1/YKL152C, a phosphoglycerate mutase; YOR283W is not an essential gene"	1	0.125	0.5	1	0.19047619	0.071428571	0.6	0.375
5310_OG5_128717_8 - MINOR CLUSTERS (FUNGI+PLANTS+BACTERIA)_YKR066C	YKR066C	"CCP1 - Mitochondrial cytochrome-c peroxidase; degrades reactive oxygen species in mitochondria, involved in the response to oxidative stress"	1	0.125	0.361111111	1	0.142857143	0	0.85	0.125
5311_OG5_129344_8 - MINOR CLUSTERS (FUNGI+PLANTS+BACTERIA)_YHR033W	YHR033W	YHR033W - Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm	1	0.0625	0.777777778	0.5	0.047619048	0.071428571	1	0.25
5312_OG5_129344_8 - MINOR CLUSTERS (FUNGI+PLANTS+BACTERIA)_YDR300C	YDR300C	"PRO1 - Gamma-glutamyl kinase, catalyzes the first step in proline biosynthesis"	1	0.0625	0.777777778	0.5	0.047619048	0.071428571	1	0.25
5313_OG5_129572_8 - MINOR CLUSTERS (FUNGI+PLANTS+BACTERIA)_YER065C	YER065C	"ICL1 - Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose"	1	0.0625	0.416666667	0.75	0.19047619	0	1	0.0625
5314_OG5_129572_8 - MINOR CLUSTERS (FUNGI+PLANTS+BACTERIA)_YPR006C	YPR006C	"ICL2 - 2-methylisocitrate lyase of the mitochondrial matrix, functions in the methylcitrate cycle to catalyze the conversion of 2-methylisocitrate to succinate and pyruvate; ICL2 transcription is repressed by glucose and induced by ethanol"	1	0.0625	0.416666667	0.75	0.19047619	0	1	0.0625
5315_OG5_131443_8 - MINOR CLUSTERS (FUNGI+PLANTS+BACTERIA)_YAR015W	YAR015W	"ADE1 - N-succinyl-5-aminoimidazole-4-carboxamide ribotide (SAICAR) synthetase, required for 'de novo' purine nucleotide biosynthesis; red pigment accumulates in mutant cells deprived of adenine"	1	0.125	0.277777778	1	0.095238095	0	0.9	0.0625
5316_OG5_127872_8 - MINOR CLUSTERS (FUNGI+PLANTS+BACTERIA)_YPR127W	YPR127W	"YPR127W - Protein of unknown function, differentially expressed during alcoholic fermentation; expression activated by transcription factor YRM1/YOR172W; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus"	1	0	0.388888889	0.75	0.095238095	0.142857143	1	0
5317_OG5_127872_8 - MINOR CLUSTERS (FUNGI+PLANTS+BACTERIA)_YJR155W	YJR155W	AAD10 - Putative aryl-alcohol dehydrogenase; similar to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role	1	0	0.388888889	0.75	0.095238095	0.142857143	1	0
5318_OG5_130317_8 - MINOR CLUSTERS (FUNGI+PLANTS+BACTERIA)_YIL053W	YIL053W	"RHR2 - Constitutively expressed isoform of DL-glycerol-3-phosphatase; involved in glycerol biosynthesis, induced in response to both anaerobic and, along with the Hor2p/Gpp2p isoform, osmotic stress"	1	0.125	0.277777778	1	0.047619048	0	0.9	0.0625
5319_OG5_130317_8 - MINOR CLUSTERS (FUNGI+PLANTS+BACTERIA)_YER062C	YER062C	"HOR2 - One of two redundant DL-glycerol-3-phosphatases (RHR2/GPP1 encodes the other) involved in glycerol biosynthesis; induced in response to hyperosmotic stress and oxidative stress, and during the diauxic transition"	1	0.125	0.277777778	1	0.047619048	0	0.9	0.0625
5320_OG5_130684_8 - MINOR CLUSTERS (FUNGI+PLANTS+BACTERIA)_YER142C	YER142C	MAG1 - 3-methyl-adenine DNA glycosylase involved in protecting DNA against alkylating agents; initiates base excision repair by removing damaged bases to create abasic sites that are subsequently repaired	1	0.125	0.277777778	0.875	0.047619048	0	0.95	0.0625
5321_OG5_131564_8 - MINOR CLUSTERS (FUNGI+PLANTS+BACTERIA)_YHL016C	YHL016C	"DUR3 - Plasma membrane transporter for both urea and polyamines, expression is highly sensitive to nitrogen catabolite repression and induced by allophanate, the last intermediate of the allantoin degradative pathway"	1	0.0625	0.083333333	1	0.095238095	0.071428571	0.9	0
5322_OG5_128780_8 - MINOR CLUSTERS (FUNGI+PLANTS+BACTERIA)_YDL128W	YDL128W	"VCX1 - Vacuolar membrane antiporter with Ca2+/H+ and K+/H+ exchange activity, involved in control of cytosolic Ca2+ and K+ concentrations; has similarity to sodium/calcium exchangers, including the bovine Na+/Ca2+,K+ antiporter"	1	0	0.416666667	0.75	0.095238095	0	0.95	0.375
5323_OG5_130066_8 - MINOR CLUSTERS (FUNGI+PLANTS+BACTERIA)_YPL092W	YPL092W	SSU1 - Plasma membrane sulfite pump involved in sulfite metabolism and required for efficient sulfite efflux; major facilitator superfamily protein	1	0.1875	0.277777778	0.625	0.095238095	0	0.9	0
5324_OG5_129209_8 - MINOR CLUSTERS (FUNGI+PLANTS+BACTERIA)_YNL217W	YNL217W	YNL217W - Putative protein of unknown function; weak sequence similarity to bis (5'-nucleotidyl)-tetraphosphatases; (GFP)-fusion protein localizes to the vacuole; null mutant is highly sensitive to azaserine and resistant to sodium-O-vandate	1	0.0625	0.583333333	0.25	0.19047619	0.071428571	0.9	0.3125
5325_OG5_129216_8 - MINOR CLUSTERS (FUNGI+PLANTS+BACTERIA)_YIL162W	YIL162W	"SUC2 - Invertase, sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively"	1	0	0.388888889	0.75	0.142857143	0	0.65	0.1875
5326_OG5_129005_8 - MINOR CLUSTERS (FUNGI+PLANTS+BACTERIA)_YHL008C	YHL008C	"YHL008C - Putative protein of unknown function, may be involved in the uptake of chloride ions; does not appear to be involved in monocarboxylic acid transport; green fluorescent protein (GFP)-fusion protein localizes to the vacuole"	1	0.125	0.361111111	0.5	0.095238095	0	0.6	0.4375
5327_OG5_128764_8 - MINOR CLUSTERS (FUNGI+PLANTS+BACTERIA)_YGR260W	YGR260W	"TNA1 - High affinity nicotinic acid plasma membrane permease, responsible for uptake of low levels of nicotinic acid; expression of the gene increases in the absence of extracellular nicotinic acid or para-aminobenzoate (PABA)"	1	0.125	0.333333333	0.25	0.047619048	0.071428571	0.85	0
5328_OG5_131639_8 - MINOR CLUSTERS (FUNGI+PLANTS+BACTERIA)_YKL060C	YKL060C	"FBA1 - Fructose 1,6-bisphosphate aldolase, required for glycolysis and gluconeogenesis; catalyzes conversion of fructose 1,6 bisphosphate to glyceraldehyde-3-P and dihydroxyacetone-P; locates to mitochondrial outer surface upon oxidative stress"	1	0	0.277777778	0.25	0.142857143	0	1	0.0625
5329_OG5_131520_8 - MINOR CLUSTERS (FUNGI+PLANTS+BACTERIA)_YER145C	YER145C	FTR1 - High affinity iron permease involved in the transport of iron across the plasma membrane; forms complex with Fet3p; expression is regulated by iron	1	0	0.25	0.25	0.047619048	0	0.85	0
5330_OG5_128522_8 - MINOR CLUSTERS (FUNGI+NONCHORDATES+CHORDATES+BACTERIA)_YHR037W	YHR037W	"PUT2 - Delta-1-pyrroline-5-carboxylate dehydrogenase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; deficiency of the human homolog causes HPII, an autosomal recessive inborn error of metabolism"	1	0.125	0.527777778	0.125	0.80952381	0.928571429	1	0.1875
5331_OG5_128410_8 - MINOR CLUSTERS (FUNGI+NONCHORDATES+CHORDATES+BACTERIA)_YOR236W	YOR236W	"DFR1 - Dihydrofolate reductase, part of the dTTP biosynthetic pathway, involved in folate metabolism, possibly required for mitochondrial function"	1	0.0625	0.694444444	0.125	0.714285714	0.928571429	0.95	0.1875
5332_OG5_128299_8 - MINOR CLUSTERS (FUNGI+NONCHORDATES+CHORDATES+BACTERIA)_YER087W	YER087W	AIM10 - Protein with similarity to tRNA synthetases; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays elevated frequency of mitochondrial genome loss	1	0	0.888888889	0	0.714285714	1	0.8	0.375
5333_OG5_128173_8 - MINOR CLUSTERS (FUNGI+NONCHORDATES+CHORDATES+BACTERIA)_YGR031W	YGR031W	IMO32 - Conserved mitochondrial protein of unknown function; processed by both mitochondrial processing peptidase and mitochondrial octapeptidyl aminopeptidase; gene contains the nested antisense gene NAG1	1	0	0.25	0.125	0.904761905	1	1	0.4375
5334_OG5_129127_8 - MINOR CLUSTERS (FUNGI+NONCHORDATES+CHORDATES+BACTERIA)_YBR035C	YBR035C	"PDX3 - Pyridoxine (pyridoxamine) phosphate oxidase, has homologs in E. coli and Myxococcus xanthus; transcription is under the general control of nitrogen metabolism"	1	0	0.472222222	0.125	0.80952381	0.857142857	0.95	0.0625
5335_OG5_128139_8 - MINOR CLUSTERS (FUNGI+NONCHORDATES+CHORDATES+BACTERIA)_YGL221C	YGL221C	"NIF3 - Protein of unknown function, similar to Listeria monocytogenes major sigma factor (rpoD gene product); the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"	1	0.1875	0.361111111	0	0.619047619	1	1	0.4375
5336_OG5_128899_8 - MINOR CLUSTERS (FUNGI+NONCHORDATES+CHORDATES+BACTERIA)_YOR125C	YOR125C	CAT5 - Protein required for ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes; required for gluconeogenic gene activation	1	0	0.222222222	0.125	0.80952381	1	1	0.3125
5337_OG5_128114_8 - MINOR CLUSTERS (FUNGI+NONCHORDATES+CHORDATES+BACTERIA)_YLR209C	YLR209C	"PNP1 - Purine nucleoside phosphorylase, specifically metabolizes inosine and guanosine nucleosides; involved in the nicotinamide riboside salvage pathway"	1	0	0.416666667	0.125	0.761904762	1	0.7	0.25
5338_OG5_126976_8 - MINOR CLUSTERS (FUNGI+NONCHORDATES+CHORDATES+BACTERIA)_YDR481C	YDR481C	"PHO8 - Repressible vacuolar alkaline phosphatase; regulated by levels of Pi and by Pho4p, Pho9p, Pho80p, Pho81p and Pho85p; dephosphorylates phosphotyrosyl peptides; contributes to NAD+ metabolism by producing nicotinamide riboside from NMN"	1	0.0625	0.333333333	0.125	0.619047619	1	0.85	0.125
5339_OG5_128588_8 - MINOR CLUSTERS (FUNGI+NONCHORDATES+CHORDATES+BACTERIA)_YML121W	YML121W	"GTR1 - Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB"	1	0	0.027777778	0	0.904761905	1	1	0.5
5340_OG5_127556_8 - MINOR CLUSTERS (FUNGI+NONCHORDATES+CHORDATES+BACTERIA)_YDR452W	YDR452W	PPN1 - Vacuolar endopolyphosphatase with a role in phosphate metabolism; functions as a homodimer	1	0	0.027777778	0	0.80952381	1	1	0.4375
5341_OG5_127788_8 - MINOR CLUSTERS (FUNGI+NONCHORDATES+CHORDATES+BACTERIA)_YNL238W	YNL238W	"KEX2 - Subtilisin-like protease (proprotein convertase), a calcium-dependent serine protease involved in the activation of proproteins of the secretory pathway"	1	0	0.027777778	0	0.761904762	1	1	0.1875
5342_OG5_131950_8 - MINOR CLUSTERS (FUNGI+NONCHORDATES+BACTERIA)_YBL015W	YBL015W	"ACH1 - Protein with CoA transferase activity, particularly for CoASH transfer from succinyl-CoA to acetate; has minor acetyl-CoA-hydrolase activity; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth"	1	0.125	0.222222222	0	0.285714286	0	0.85	0.0625
5343_OG5_129764_8 - MINOR CLUSTERS (FUNGI+CHORDATES+BACTERIA)_YER026C	YER026C	"CHO1 - Phosphatidylserine synthase, functions in phospholipid biosynthesis; catalyzes the reaction CDP-diaclyglycerol + L-serine = CMP + L-1-phosphatidylserine, transcriptionally repressed by myo-inositol and choline"	1	0.375	0.583333333	0.125	0	0.714285714	1	0.0625
5344_OG5_130710_8 - MINOR CLUSTERS (FUNGI+BACTERIA)_YGR234W	YGR234W	"YHB1 - Nitric oxide oxidoreductase, flavohemoglobin involved in nitric oxide detoxification; plays a role in the oxidative and nitrosative stress responses"	1	0	0.472222222	0.125	0.142857143	0.071428571	0.8	0.125
5345_OG5_129003_8 - MINOR CLUSTERS (FUNGI+BACTERIA)_YBR249C	YBR249C	"ARO4 - 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by tyrosine or high concentrations of phenylalanine or tryptophan"	1	0	0.472222222	0	0.095238095	0	1	0.0625
5346_OG5_129003_8 - MINOR CLUSTERS (FUNGI+BACTERIA)_YDR035W	YDR035W	"ARO3 - 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by phenylalanine or high concentration of tyrosine or tryptophan"	1	0	0.472222222	0	0.095238095	0	1	0.0625
5347_OG5_130873_8 - MINOR CLUSTERS (FUNGI+BACTERIA)_YKL069W	YKL069W	"YKL069W - Methionine-R-sulfoxide reductase, reduces the R enantiomer of free Met-SO, in contrast to Ycl033Cp which reduces Met-R-SO in a peptide linkage; has a role in protection against oxidative stress"	1	0.0625	0.361111111	0.125	0.095238095	0	0.9	0.3125
5348_OG5_129571_8 - MINOR CLUSTERS (FUNGI+BACTERIA)_YLR308W	YLR308W	"CDA2 - Chitin deacetylase, together with Cda1p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall"	1	0.0625	0.333333333	0	0.047619048	0.142857143	0.95	0
5349_OG5_129571_8 - MINOR CLUSTERS (FUNGI+BACTERIA)_YLR307W	YLR307W	"CDA1 - Chitin deacetylase, together with Cda2p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall"	1	0.0625	0.333333333	0	0.047619048	0.142857143	0.95	0
5350_OG5_132031_8 - MINOR CLUSTERS (FUNGI+BACTERIA)_YDR061W	YDR061W	YDR061W - Protein with similarity to ATP-binding cassette (ABC) transporter family members; lacks predicted membrane-spanning regions; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance	1	0	0.388888889	0.125	0.047619048	0	0.95	0.0625
5351_OG5_127087_8 - MINOR CLUSTERS (FUNGI+BACTERIA)_YNL268W	YNL268W	"LYP1 - Lysine permease; one of three amino acid permeases (Alp1p, Can1p, Lyp1p) responsible for uptake of cationic amino acids"	1	0	0.472222222	0	0	0.071428571	0.95	0.125
5352_OG5_127087_8 - MINOR CLUSTERS (FUNGI+BACTERIA)_YKR039W	YKR039W	GAP1 - General amino acid permease; Gap1p senses the presence of amino acid substrates to regulate localization to the plasma membrane when needed	1	0	0.472222222	0	0	0.071428571	0.95	0.125
5353_OG5_127087_8 - MINOR CLUSTERS (FUNGI+BACTERIA)_YNL270C	YNL270C	ALP1 - Arginine transporter; expression is normally very low and it is unclear what conditions would induce significant expression	1	0	0.472222222	0	0	0.071428571	0.95	0.125
5354_OG5_127087_8 - MINOR CLUSTERS (FUNGI+BACTERIA)_YEL063C	YEL063C	"CAN1 - Plasma membrane arginine permease, requires phosphatidyl ethanolamine (PE) for localization, exclusively associated with lipid rafts; mutation confers canavanine resistance"	1	0	0.472222222	0	0	0.071428571	0.95	0.125
5355_OG5_130884_8 - MINOR CLUSTERS (FUNGI+BACTERIA)_YPL148C	YPL148C	"PPT2 - Phosphopantetheine:protein transferase (PPTase), activates mitochondrial acyl carrier protein (Acp1p) by phosphopantetheinylation"	1	0	0.888888889	0	0.095238095	0	0.35	0.125
5356_OG5_133992_8 - MINOR CLUSTERS (FUNGI+BACTERIA)_YCL038C	YCL038C	ATG22 - Vacuolar integral membrane protein required for efflux of amino acids during autophagic body breakdown in the vacuole; null mutation causes a gradual loss of viability during starvation	1	0.0625	0.277777778	0.125	0	0	0.85	0
5357_OG5_131754_8 - MINOR CLUSTERS (FUNGI+BACTERIA)_YNR057C	YNR057C	"BIO4 - Dethiobiotin synthetase, catalyzes the third step in the biotin biosynthesis pathway; BIO4 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis; expression appears to be repressed at low iron levels"	1	0.1875	0.75	0.125	0	0	0.25	0
5358_OG5_131513_8 - MINOR CLUSTERS (FUNGI+BACTERIA)_YOR209C	YOR209C	"NPT1 - Nicotinate phosphoribosyltransferase, acts in the salvage pathway of NAD+ biosynthesis; required for silencing at rDNA and telomeres and has a role in silencing at mating-type loci; localized to the nucleus"	1	0	0.305555556	0	0.047619048	0	0.95	0.1875
5359_OG5_129515_8 - MINOR CLUSTERS (FUNGI+BACTERIA)_YLL057C	YLL057C	"JLP1 - Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase, involved in sulfonate catabolism for use as a sulfur source; contains sequence that resembles a J domain (typified by the E. coli DnaJ protein); induced by sulphur starvation"	1	0	0.25	0.125	0.047619048	0	0.75	0.0625
5360_OG5_136808_8 - MINOR CLUSTERS (FUNGI+BACTERIA)_YFR055W	YFR055W	"IRC7 - Beta-lyase involved in the production of thiols; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner and by copper levels in a Mac1-dependent manner"	1	0	0.333333333	0.125	0.047619048	0	0.05	0.0625
5361_OG5_137048_8 - MINOR CLUSTERS (FUNGI+BACTERIA)_Q0050	Q0050	"AI1 - Reverse transcriptase required for splicing of the COX1 pre-mRNA, encoded by a mobile group II intron within the mitochondrial COX1 gene"	1	0	0.25	0.125	0	0	0.1	0
5362_OG5_137048_8 - MINOR CLUSTERS (FUNGI+BACTERIA)_Q0055	Q0055	"AI2 - Reverse transcriptase required for splicing of the COX1 pre-mRNA, encoded by a mobile group II intron within the mitochondrial COX1 gene"	1	0	0.25	0.125	0	0	0.1	0
5363_OG5_140132_8 - MINOR CLUSTERS (FUNGI+BACTERIA)_YML087C	YML087C	"AIM33 - Putative protein of unknown function, highly conserved across species and orthologous to human CYB5R4; null mutant displays reduced frequency of mitochondrial genome loss"	1	0.0625	0.305555556	0	0.047619048	0	0.05	0
5364_OG5_128638_8 - MINOR CLUSTERS (FUNGI+NONCHORDATES+PLANTS+ARCHAEA)_YGL245W	YGL245W	"GUS1 - Glutamyl-tRNA synthetase (GluRS), forms a complex with methionyl-tRNA synthetase (Mes1p) and Arc1p; complex formation increases the catalytic efficiency of both tRNA synthetases and ensures their correct localization to the cytoplasm"	1	0.625	0	0.875	0.428571429	0.142857143	0.95	0.9375
5365_OG5_127743_8 - MINOR CLUSTERS (FUNGI+NONCHORDATES+PLANTS+ARCHAEA)_YML123C	YML123C	PHO84 - High-affinity inorganic phosphate (Pi) transporter and low-affinity manganese transporter; regulated by Pho4p and Spt7p; mutation confers resistance to arsenate; exit from the ER during maturation requires Pho86p	1	0.25	0.083333333	0.75	0.238095238	0.142857143	1	0.0625
5366_OG5_130225_8 - MINOR CLUSTERS (FUNGI+NONCHORDATES+PLANTS+ARCHAEA)_YGR210C	YGR210C	YGR210C - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	1	1	0	0.375	0.238095238	0.071428571	0.75	0.4375
5367_OG5_130740_8 - MINOR CLUSTERS (FUNGI+PLANTS+ARCHAEA)_YDR291W	YDR291W	HRQ1 - Putative RecQ helicase; belongs to the widely conserved RecQ family of proteins which are involved in maintaining genomic integrity; similar to the human RecQ4p implicated in Rothmund-Thomson syndrome(RTS)	1	0.625	0.083333333	1	0.19047619	0	0.9	0.125
5368_OG5_131050_8 - MINOR CLUSTERS (FUNGI+PLANTS+ARCHAEA)_YGR144W	YGR144W	"THI4 - Thiazole synthase, catalyzes formation of a thiazole intermediate during thiamine biosynthesis; required for mitochondrial genome stability in response to DNA damaging agents"	1	0.8125	0.027777778	0.75	0	0	0.85	0
5369_OG5_129158_8 - MINOR CLUSTERS (FUNGI+PLANTS+ARCHAEA)_YLR044C	YLR044C	"PDC1 - Major of three pyruvate decarboxylase isozymes, key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde; subject to glucose-, ethanol-, and autoregulation; involved in amino acid catabolism"	1	0.25	0.194444444	0.75	0.047619048	0	1	0.125
5370_OG5_129158_8 - MINOR CLUSTERS (FUNGI+PLANTS+ARCHAEA)_YLR134W	YLR134W	"PDC5 - Minor isoform of pyruvate decarboxylase, key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde, regulation is glucose- and ethanol-dependent, repressed by thiamine, involved in amino acid catabolism"	1	0.25	0.194444444	0.75	0.047619048	0	1	0.125
5371_OG5_129158_8 - MINOR CLUSTERS (FUNGI+PLANTS+ARCHAEA)_YGR087C	YGR087C	"PDC6 - Minor isoform of pyruvate decarboxylase, decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation"	1	0.25	0.194444444	0.75	0.047619048	0	1	0.125
5372_OG5_129349_8 - MINOR CLUSTERS (FUNGI+PLANTS+ARCHAEA)_YNR002C	YNR002C	"ATO2 - Putative transmembrane protein involved in export of ammonia, a starvation signal that promotes cell death in aging colonies; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family; homolog of Ady2p and Y. lipolytica Gpr1p"	1	0.3125	0.194444444	0.5	0.095238095	0	1	0.0625
5373_OG5_129349_8 - MINOR CLUSTERS (FUNGI+PLANTS+ARCHAEA)_YCR010C	YCR010C	ADY2 - Acetate transporter required for normal sporulation; phosphorylated in mitochondria	1	0.3125	0.194444444	0.5	0.095238095	0	1	0.0625
5374_OG5_132932_8 - MINOR CLUSTERS (FUNGI+PLANTS+ARCHAEA)_YJR124C	YJR124C	YJR124C - Putative protein of unknown function; expression induced under calcium shortage	1	0.3125	0.111111111	0.375	0	0	0.65	0
5375_OG5_133329_8 - MINOR CLUSTERS (FUNGI+PLANTS+ARCHAEA)_YJL213W	YJL213W	"YJL213W - Protein of unknown function that may interact with ribosomes; periodically expressed during the yeast metabolic cycle; phosphorylated in vitro by the mitotic exit network (MEN) kinase complex, Dbf2p/Mob1p"	1	0.25	0.083333333	0.5	0	0	0.4	0
5376_OG5_128424_8 - MINOR CLUSTERS (FUNGI+NONCHORDATES+CHORDATES+ARCHAEA+BACTERIA)_YLR017W	YLR017W	"MEU1 - Methylthioadenosine phosphorylase (MTAP), catalyzes the initial step in the methionine salvage pathway; affects polyamine biosynthesis through regulation of ornithine decarboxylase (Spe1p) activity; regulates ADH2 gene expression"	1	0.9375	0.194444444	0	0.714285714	1	1	0.3125
5377_OG5_130176_8 - MINOR CLUSTERS (FUNGI+NONCHORDATES+CHORDATES+ARCHAEA+BACTERIA)_YHR117W	YHR117W	TOM71 - Mitochondrial outer membrane protein with similarity to Tom70p; probable minor component of the TOM (translocase of outer membrane) complex responsible for recognition and import of mitochondrially directed proteins	1	0.0625	0	0.125	0.666666667	1	1	0.125
5378_OG5_130176_8 - MINOR CLUSTERS (FUNGI+NONCHORDATES+CHORDATES+ARCHAEA+BACTERIA)_YNL121C	YNL121C	TOM70 - Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; acts as a receptor for incoming precursor proteins	1	0.0625	0	0.125	0.666666667	1	1	0.125
5379_OG5_126892_8 - MINOR CLUSTERS (FUNGI+NONCHORDATES+PLANTS+ARCHAEA+BACTERIA)_YDL171C	YDL171C	"GLT1 - NAD(+)-dependent glutamate synthase (GOGAT), synthesizes glutamate from glutamine and alpha-ketoglutarate; with Gln1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source"	1	0.8125	0.833333333	1	0.857142857	0	0.95	0.25
5380_OG5_126686_8 - MINOR CLUSTERS (FUNGI+NONCHORDATES+PLANTS+ARCHAEA+BACTERIA)_YGR121C	YGR121C	MEP1 - Ammonium permease; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation	1	0.6875	0.611111111	1	0.857142857	0.142857143	1	0.125
5381_OG5_126686_8 - MINOR CLUSTERS (FUNGI+NONCHORDATES+PLANTS+ARCHAEA+BACTERIA)_YNL142W	YNL142W	MEP2 - Ammonium permease involved in regulation of pseudohyphal growth; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation	1	0.6875	0.611111111	1	0.857142857	0.142857143	1	0.125
5382_OG5_126686_8 - MINOR CLUSTERS (FUNGI+NONCHORDATES+PLANTS+ARCHAEA+BACTERIA)_YPR138C	YPR138C	MEP3 - Ammonium permease of high capacity and low affinity; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation ammonia permease	1	0.6875	0.611111111	1	0.857142857	0.142857143	1	0.125
5383_OG5_127752_8 - MINOR CLUSTERS (FUNGI+NONCHORDATES+PLANTS+ARCHAEA+BACTERIA)_YGL037C	YGL037C	"PNC1 - Nicotinamidase that converts nicotinamide to nicotinic acid as part of the NAD(+) salvage pathway, required for life span extension by calorie restriction; PNC1 expression responds to all known stimuli that extend replicative life span"	1	0.625	0.611111111	0.5	0.761904762	0.071428571	1	0.5
5384_OG5_129260_8 - MINOR CLUSTERS (FUNGI+NONCHORDATES+PLANTS+ARCHAEA+BACTERIA)_YMR095C	YMR095C	"SNO1 - Protein of unconfirmed function, involved in pyridoxine metabolism; expression is induced during stationary phase; forms a putative glutamine amidotransferase complex with Snz1p, with Sno1p serving as the glutaminase"	1	0.9375	0.305555556	1	0.238095238	0.071428571	0.95	0.25
5385_OG5_129260_8 - MINOR CLUSTERS (FUNGI+NONCHORDATES+PLANTS+ARCHAEA+BACTERIA)_YNL334C	YNL334C	"SNO2 - Protein of unknown function, nearly identical to Sno3p; expression is induced before the diauxic shift and also in the absence of thiamin"	1	0.9375	0.305555556	1	0.238095238	0.071428571	0.95	0.25
5386_OG5_129260_8 - MINOR CLUSTERS (FUNGI+NONCHORDATES+PLANTS+ARCHAEA+BACTERIA)_YFL060C	YFL060C	"SNO3 - Protein of unknown function, nearly identical to Sno2p; expression is induced before the diauxic shift and also in the absence of thiamin"	1	0.9375	0.305555556	1	0.238095238	0.071428571	0.95	0.25
5387_OG5_128957_8 - MINOR CLUSTERS (FUNGI+NONCHORDATES+PLANTS+ARCHAEA+BACTERIA)_YMR096W	YMR096W	"SNZ1 - Protein involved in vitamin B6 biosynthesis; member of a stationary phase-induced gene family; coregulated with SNO1; interacts with Sno1p and with Yhr198p, perhaps as a multiprotein complex containing other Snz and Sno proteins"	1	0.875	0.305555556	1	0.285714286	0.071428571	0.95	0.25
5388_OG5_128957_8 - MINOR CLUSTERS (FUNGI+NONCHORDATES+PLANTS+ARCHAEA+BACTERIA)_YNL333W	YNL333W	"SNZ2 - Member of a stationary phase-induced gene family; transcription of SNZ2 is induced prior to diauxic shift, and also in the absence of thiamin in a Thi2p-dependent manner; forms a coregulated gene pair with SNO2; interacts with Thi11p"	1	0.875	0.305555556	1	0.285714286	0.071428571	0.95	0.25
5389_OG5_128957_8 - MINOR CLUSTERS (FUNGI+NONCHORDATES+PLANTS+ARCHAEA+BACTERIA)_YFL059W	YFL059W	"SNZ3 - Member of a stationary phase-induced gene family; transcription of SNZ2 is induced prior to diauxic shift, and also in the absence of thiamin in a Thi2p-dependent manner; forms a coregulated gene pair with SNO3"	1	0.875	0.305555556	1	0.285714286	0.071428571	0.95	0.25
5390_OG5_126960_8 - MINOR CLUSTERS (FUNGI+NONCHORDATES+PLANTS+ARCHAEA+BACTERIA)_YML120C	YML120C	"NDI1 - NADH:ubiquinone oxidoreductase, transfers electrons from NADH to ubiquinone in the respiratory chain but does not pump protons, in contrast to the higher eukaryotic multisubunit respiratory complex I; phosphorylated; homolog of human AMID"	1	0.375	0.611111111	1	0.285714286	0.071428571	1	0.625
5391_OG5_126960_8 - MINOR CLUSTERS (FUNGI+NONCHORDATES+PLANTS+ARCHAEA+BACTERIA)_YMR145C	YMR145C	"NDE1 - Mitochondrial external NADH dehydrogenase, a type II NAD(P)H:quinone oxidoreductase that catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p provide cytosolic NADH to the mitochondrial respiratory chain"	1	0.375	0.611111111	1	0.285714286	0.071428571	1	0.625
5392_OG5_126960_8 - MINOR CLUSTERS (FUNGI+NONCHORDATES+PLANTS+ARCHAEA+BACTERIA)_YDL085W	YDL085W	"NDE2 - Mitochondrial external NADH dehydrogenase, catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p are involved in providing the cytosolic NADH to the mitochondrial respiratory chain"	1	0.375	0.611111111	1	0.285714286	0.071428571	1	0.625
5393_OG5_126661_8 - MINOR CLUSTERS (FUNGI+NONCHORDATES+PLANTS+ARCHAEA+BACTERIA)_YOL086C	YOL086C	"ADH1 - Alcohol dehydrogenase, fermentative isozyme active as homo- or heterotetramers; required for the reduction of acetaldehyde to ethanol, the last step in the glycolytic pathway"	1	0.375	0.5	1	0.285714286	0.142857143	1	0.25
5394_OG5_126661_8 - MINOR CLUSTERS (FUNGI+NONCHORDATES+PLANTS+ARCHAEA+BACTERIA)_YBR145W	YBR145W	ADH5 - Alcohol dehydrogenase isoenzyme V; involved in ethanol production	1	0.375	0.5	1	0.285714286	0.142857143	1	0.25
5395_OG5_126661_8 - MINOR CLUSTERS (FUNGI+NONCHORDATES+PLANTS+ARCHAEA+BACTERIA)_YMR083W	YMR083W	ADH3 - Mitochondrial alcohol dehydrogenase isozyme III; involved in the shuttling of mitochondrial NADH to the cytosol under anaerobic conditions and ethanol production	1	0.375	0.5	1	0.285714286	0.142857143	1	0.25
5396_OG5_126661_8 - MINOR CLUSTERS (FUNGI+NONCHORDATES+PLANTS+ARCHAEA+BACTERIA)_YCR105W	YCR105W	ADH7 - NADPH-dependent medium chain alcohol dehydrogenase with broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance	1	0.375	0.5	1	0.285714286	0.142857143	1	0.25
5397_OG5_126661_8 - MINOR CLUSTERS (FUNGI+NONCHORDATES+PLANTS+ARCHAEA+BACTERIA)_YMR318C	YMR318C	ADH6 - NADPH-dependent medium chain alcohol dehydrogenase with broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance	1	0.375	0.5	1	0.285714286	0.142857143	1	0.25
5398_OG5_126661_8 - MINOR CLUSTERS (FUNGI+NONCHORDATES+PLANTS+ARCHAEA+BACTERIA)_YMR303C	YMR303C	"ADH2 - Glucose-repressible alcohol dehydrogenase II, catalyzes the conversion of ethanol to acetaldehyde; involved in the production of certain carboxylate esters; regulated by ADR1"	1	0.375	0.5	1	0.285714286	0.142857143	1	0.25
5399_OG5_128464_8 - MINOR CLUSTERS (FUNGI+CHORDATES+PLANTS+ARCHAEA+BACTERIA)_YER069W	YER069W	"ARG5,6 - Protein that is processed in the mitochondrion to yield acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase, which catalyze the 2nd and 3rd steps in arginine biosynthesis; enzymes form a complex with Arg2p"	1	0.6875	0.722222222	1	0.19047619	0.785714286	0.95	0.0625
5400_OG5_128943_8 - MINOR CLUSTERS (FUNGI+PLANTS+ARCHAEA+BACTERIA)_YOR303W	YOR303W	"CPA1 - Small subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor; translationally regulated by an attenuator peptide encoded by YOR302W within the CPA1 mRNA 5'-leader"	1	0.8125	0.888888889	1	0.047619048	0.142857143	1	0
5401_OG5_128072_8 - MINOR CLUSTERS (FUNGI+PLANTS+ARCHAEA+BACTERIA)_YDL131W	YDL131W	"LYS21 - Homocitrate synthase isozyme, catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; highly similar to the other isozyme, Lys20p"	1	0.75	0.638888889	1	0.19047619	0.071428571	1	0.0625
5402_OG5_128072_8 - MINOR CLUSTERS (FUNGI+PLANTS+ARCHAEA+BACTERIA)_YDL182W	YDL182W	"LYS20 - Homocitrate synthase isozyme, catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; highly similar to the other isozyme, Lys21p"	1	0.75	0.638888889	1	0.19047619	0.071428571	1	0.0625
5403_OG5_129099_8 - MINOR CLUSTERS (FUNGI+PLANTS+ARCHAEA+BACTERIA)_YCL030C	YCL030C	"HIS4 - Multifunctional enzyme containing phosphoribosyl-ATP pyrophosphatase, phosphoribosyl-AMP cyclohydrolase, and histidinol dehydrogenase activities; catalyzes the second, third, ninth and tenth steps in histidine biosynthesis"	1	0.6875	0.722222222	1	0.142857143	0.071428571	1	0.0625
5404_OG5_129102_8 - MINOR CLUSTERS (FUNGI+PLANTS+ARCHAEA+BACTERIA)_YER055C	YER055C	"HIS1 - ATP phosphoribosyltransferase, a hexameric enzyme, catalyzes the first step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control"	1	0.6875	0.694444444	1	0.142857143	0.071428571	1	0.0625
5405_OG5_128726_8 - MINOR CLUSTERS (FUNGI+PLANTS+ARCHAEA+BACTERIA)_YMR177W	YMR177W	MMT1 - Putative metal transporter involved in mitochondrial iron accumulation; closely related to Mmt2p	1	0.5625	0.694444444	0.625	0.047619048	0.071428571	1	0.25
5406_OG5_128726_8 - MINOR CLUSTERS (FUNGI+PLANTS+ARCHAEA+BACTERIA)_YPL224C	YPL224C	MMT2 - Putative metal transporter involved in mitochondrial iron accumulation; closely related to Mmt1p	1	0.5625	0.694444444	0.625	0.047619048	0.071428571	1	0.25
5407_OG5_126664_8 - MINOR CLUSTERS (FUNGI+PLANTS+ARCHAEA+BACTERIA)_YDR119W	YDR119W	VBA4 - Protein of unknown function with proposed role as a basic amino acid permease based on phylogeny; GFP-fusion protein localizes to vacuolar membrane; physical interaction with Atg27p suggests a possible role in autophagy; non-essential gene	1	0.5	0.75	0.125	0.142857143	0.071428571	1	0.0625
5408_OG5_126664_8 - MINOR CLUSTERS (FUNGI+PLANTS+ARCHAEA+BACTERIA)_YKR105C	YKR105C	VBA5 - Putative transporter of the Major Facilitator Superfamily (MFS); proposed role as a basic amino acid permease based on phylogeny	1	0.5	0.75	0.125	0.142857143	0.071428571	1	0.0625
5409_OG5_126664_8 - MINOR CLUSTERS (FUNGI+PLANTS+ARCHAEA+BACTERIA)_YCL069W	YCL069W	VBA3 - Permease of basic amino acids in the vacuolar membrane	1	0.5	0.75	0.125	0.142857143	0.071428571	1	0.0625
5410_OG5_126664_8 - MINOR CLUSTERS (FUNGI+PLANTS+ARCHAEA+BACTERIA)_YMR088C	YMR088C	VBA1 - Permease of basic amino acids in the vacuolar membrane	1	0.5	0.75	0.125	0.142857143	0.071428571	1	0.0625
5411_OG5_126664_8 - MINOR CLUSTERS (FUNGI+PLANTS+ARCHAEA+BACTERIA)_YPR198W	YPR198W	"SGE1 - Plasma membrane multidrug transporter of the major facilitator superfamily, acts as an extrusion permease; partial multicopy suppressor of gal11 mutations"	1	0.5	0.75	0.125	0.142857143	0.071428571	1	0.0625
5412_OG5_126664_8 - MINOR CLUSTERS (FUNGI+PLANTS+ARCHAEA+BACTERIA)_YGR224W	YGR224W	"AZR1 - Plasma membrane transporter of the major facilitator superfamily, involved in resistance to azole drugs such as ketoconazole and fluconazole"	1	0.5	0.75	0.125	0.142857143	0.071428571	1	0.0625
5413_OG5_127533_8 - MINOR CLUSTERS (FUNGI+NONCHORDATES+CHORDATES+ARCHAEA+BACTERIA)_YJL046W	YJL046W	"AIM22 - Putative lipoate-protein ligase, required along with Lip2 and Lip5 for lipoylation of Lat1p and Kgd2p; similar to E. coli LplA; null mutant displays reduced frequency of mitochondrial genome loss"	1	0.4375	0.5	0.125	0.80952381	0.928571429	1	0.6875
5414_OG5_126658_8 - MINOR CLUSTERS (FUNGI+NONCHORDATES+CHORDATES+ARCHAEA+BACTERIA)_YHL036W	YHL036W	"MUP3 - Low affinity methionine permease, similar to Mup1p"	1	0.375	0.444444444	0.125	0.761904762	1	0.95	0.25
5415_OG5_129467_8 - MINOR CLUSTERS (FUNGI+NONCHORDATES+CHORDATES+ARCHAEA+BACTERIA)_YKL114C	YKL114C	"APN1 - Major apurinic/apyrimidinic endonuclease, 3'-repair diesterase involved in repair of DNA damage by oxidation and alkylating agents; also functions as a 3'-5' exonuclease to repair 7,8-dihydro-8-oxodeoxyguanosine"	1	0.3125	0.472222222	0	0.333333333	0.214285714	0.95	0.5625
5416_OG5_128176_8 - MINOR CLUSTERS (FUNGI+NONCHORDATES+CHORDATES+ARCHAEA+BACTERIA)_YLR359W	YLR359W	"ADE13 - Adenylosuccinate lyase, catalyzes two steps in the 'de novo' purine nucleotide biosynthetic pathway; expression is repressed by adenine and activated by Bas1p and Pho2p; mutations in human ortholog ADSL cause adenylosuccinase deficiency"	1	0.625	0.694444444	0.125	0.714285714	1	1	0.125
5417_OG5_131637_8 - MINOR CLUSTERS (FUNGI+ARCHAEA+BACTERIA)_YBR213W	YBR213W	"MET8 - Bifunctional dehydrogenase and ferrochelatase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis"	1	0.75	0.25	0	0	0	1	0
5418_OG5_130277_8 - MINOR CLUSTERS (FUNGI+ARCHAEA+BACTERIA)_YDR539W	YDR539W	FDC1 - Putative phenylacrylic acid decarboxylase; essential for the decarboxylation of aromatic carboxylic acids to the corresponding vinyl derivatives; homolog of E. coli UbiD; GFP-fusion protein localizes to the cytoplasm	1	0.8125	0.611111111	0.125	0	0	0.4	0.0625
5419_OG5_129134_8 - MINOR CLUSTERS (FUNGI+ARCHAEA+BACTERIA)_YKL217W	YKL217W	"JEN1 - Monocarboxylate/proton symporter of the plasma membrane; transport activity is dependent on the pH gradient across the membrane; mediates high-affinity uptake of carbon sources lactate, pyuvate, and acetate, and also of the micronutrient selenite, whose structure mimics that of monocarboxylates; expression and localization are tightly regulated, with transcription repression, mRNA degradation, and protein endocytosis and degradation all occurring in the presence of glucose"	1	0.3125	0.333333333	0.125	0.095238095	0.142857143	0.9	0.0625
5420_OG5_130545_8 - MINOR CLUSTERS (FUNGI+ARCHAEA+BACTERIA)_YER010C	YER010C	"YER010C - Protein of unknown function, forms a ring-shaped homotrimer; has similarity to members of the prokaryotic rraA family; possibly involved in a phosphotransfer reaction"	1	0.6875	0.25	0	0	0	0.95	0.0625
5421_OG5_131043_8 - MINOR CLUSTERS (FUNGI+ARCHAEA+BACTERIA)_YDR538W	YDR538W	"PAD1 - Phenylacrylic acid decarboxylase, confers resistance to cinnamic acid, decarboxylates aromatic carboxylic acids to the corresponding vinyl derivatives; also has mRNA binding activity; homolog of E. coli UbiX"	1	0.75	0.611111111	0.125	0	0	0.4	0
5422_OG5_132149_8 - MINOR CLUSTERS (FUNGI+ARCHAEA+BACTERIA)_YBL001C	YBL001C	"ECM15 - Non-essential protein of unknown function, likely exists as tetramer, may be regulated by the binding of small-molecule ligands (possibly sulfate ions), may have a role in yeast cell-wall biogenesis"	1	0.6875	0.222222222	0	0	0	0.9	0
#N/A	YBL071C-B	"YBL071C-B - Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YDL241W	YDL241W - Putative protein of unknown function; YDL241W is not an essential gene	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YDR114C	YDR114C - Putative protein of unknown function; deletion mutant exhibits poor growth at elevated pH and calcium	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YGL041C-B	YGL041C-B - Putative protein of unknown function; identified by fungal homology and RT-PCR	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YGL188C-A	YGL188C-A - Putative protein of unknown function	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YIL092W	YIL092W - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YIR016W	YIR016W - Putative protein of unknown function; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p; overexpression causes a cell cycle delay or arrest; YIR016W is a non-essential gene	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YJR079W	YJR079W - Putative protein of unknown function; mutation results in impaired mitochondrial respiration	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YKL096C-B	"YKL096C-B - Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YMR242W-A	YMR242W-A - Putative protein of unknown function	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YOL014W	YOL014W - Putative protein of unknown function	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YCR050C	YCR050C - Non-essential protein of unknown function; deletion mutant is synthetically sick or lethal with alpha-synuclein	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YOR012W	YOR012W - Putative protein of unknown function	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YIL165C	"YIL165C - Putative protein of unknown function; mutant exhibits mitophagy defects; in closely related species and other S. cerevisiae strain backgrounds YIL165C and adjacent ORF, YIL164C, likely constitute a single ORF encoding a nitrilase gene"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YKL121W	DGR2 - Protein of unknown function; null mutant is resistant to 2-deoxy-D-glucose and displays abnormally elongated buds	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YNR004W	SWM2 - Putative protein of unknown function; haploid disruptant exhibits cold-sensitive growth and elongated buds	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YKL023W	"YKL023W - Putative protein of unknown function, predicted by computational methods to be involved in mRNA degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YDR042C	YDR042C - Putative protein of unknown function; expression is increased in ssu72-ts69 mutant	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YOL162W	YOL162W - Putative protein of unknown function; member of the Dal5p subfamily of the major facilitator family	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YNL046W	YNL046W - Putative protein of unknown function; expression depends on Swi5p; GFP-fusion protein localizes to the endoplasmic reticulum; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YOR008C-A	"YOR008C-A - Putative protein of unknown function, includes a potential transmembrane domain; deletion results in slightly lengthened telomeres"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YNL196C	SLZ1 - Sporulation-specific protein with a leucine zipper motif	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YEL033W	"MTC7 - Predicted metabolic role based on network analysis derived from ChIP experiments, a large-scale deletion study and localization of transcription factor binding sites; null mutant is sensitive to temperature oscillation in a cdc13-1 mutant"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YLR312C	YLR312C - Putative protein of unknown function	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YJL107C	"YJL107C - Putative protein of unknown function; expression is induced by activation of the HOG1 mitogen-activated signaling pathway and this induction is Hog1p/Pbs2p dependent; YJL107C and adjacent ORF, YJL108C are merged in related fungi"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YEL057C	YEL057C - Protein of unknown function involved in telomere maintenance; target of UME6 regulation	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YLR042C	YLR042C - Protein of unknown function; localizes to the cytoplasm; YLL042C is not an essential gene	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YOR183W	"FYV12 - Protein of unknown function, required for survival upon exposure to K1 killer toxin"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YPR174C	YPR174C - Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nuclear periphery; potential Cdc28p substrate; binds phosphatidylinositols and phosphatidylethanolamine in a large-scale study	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YBR013C	"YBR013C - Putative protein of unknown function, haploid deletion mutant exhibits synthetic phenotype with alpha-synuclein"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YBR219C	YBR219C - Putative protein of unknown function; YBR219C is not an essential gene	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YBR284W	YBR284W - Putative protein of unknown function; YBR284W is not an essential gene; null mutant exhibits decreased resistance to rapamycin and wortmannin and synthetic phenotype with alpha-synuclein	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YCL001W-A	YCL001W-A - Putative protein of unknown function; YCL001W-A gene has similarity to DOM34 and is present in a region duplicated between chromosomes XIV and III	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YEL025C	YEL025C - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YEL067C	"YEL067C - Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YER039C-A	YER039C-A - Putative protein of unknown function; YER039C-A is not an essential gene	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YER066W	RRT13 - Putative protein of unknown function; non-essential gene identified in a screen for mutants with decreased levels of rDNA transcription	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YER085C	YER085C - Putative protein of unknown function	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YER121W	YER121W - Putative protein of unknown function; may be involved in phosphatase regulation and/or generation of precursor metabolites and energy	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YFL012W	YFL012W - Putative protein of unknown function; transcribed during sporulation; null mutant exhibits increased resistance to rapamycin	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YFR012W	YFR012W - Putative protein of unknown function	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YFR035C	"YFR035C - Putative protein of unknown function, deletion mutant exhibits synthetic phenotype with alpha-synuclein"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YGL230C	YGL230C - Putative protein of unknown function; non-essential gene	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YGR035C	"YGR035C - Putative protein of unknown function, potential Cdc28p substrate; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YGR153W	YGR153W - Putative protein of unknown function	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YHL012W	"YHL012W - Putative protein of unknown function, has some homology to Ugp1p, which encodes UDP-glucose pyrophosphorylase"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YHR126C	ANS1 - Putative protein of unknown function; transcription dependent upon Azf1p	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YIL152W	YIL152W - Putative protein of unknown function	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YJL027C	YJL027C - Putative protein of unknown function	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YJL160C	"YJL160C - Putative protein of unknown function; member of the PIR (proteins with internal repeats) family of cell wall proteins; non-essential gene that is required for sporulation; mRNA is weakly cell cycle regulated, peaking in mitosis"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YJL185C	"YJL185C - Putative protein of unknown function; mRNA is weakly cell cycle regulated, peaking in G2 phase; YJL185C is a non-essential gene"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YJR011C	YJR011C - Putative protein of unknown function; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YJR115W	YJR115W - Putative protein of unknown function	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YLR225C	YLR225C - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR225C is not an essential gene	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YLR346C	"YLR346C - Putative protein of unknown function found in mitochondria; expression is regulated by transcription factors involved in pleiotropic drug resistance, Pdr1p and Yrr1p; YLR346C is not an essential gene"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YML003W	YML003W - Putative protein of unknown function	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YMR018W	YMR018W - Putative protein of unknown function with similarity to human PEX5Rp (peroxin protein 5 related protein); transcription increases during colony development similar to genes involved in peroxisome biogenesis; YMR018W is not an essential gene	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YMR085W	YMR085W - Putative protein of unknown function; YMR085W and adjacent ORF YMR084W are merged in related strains	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YNR068C	YNR068C - Putative protein of unknown function	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YOL024W	YOL024W - Putative protein of unknown function; predicted to have thiol-disulfide oxidoreductase active site	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YOL029C	YOL029C - Putative protein of unknown function; identified as interacting with Hsc82p and Hsp82p in high-throughput two-hybrid screens	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YOR186W	YOR186W - Putative protein of unknown function; proper regulation of expression during heat stress is sphingolipid-dependent	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YOR268C	YOR268C - Putative protein of unknown function; sporulation is abnormal in homozygous diploid; YOR268C is not an essential gene	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YOR365C	YOR365C - Putative protein of unknown function; YOR365C is not an essential protein	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YPL216W	YPL216W - Putative protein of unknown function; YPL216W is not an essential gene	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YPR027C	YPR027C - Putative protein of unknown function	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YPR078C	YPR078C - Putative protein of unknown function; possible role in DNA metabolism and/or in genome stability; expression is heat-inducible	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YDL118W	"YDL118W - Non-essential protein of unconfirmed function; mutants are defective in telomere maintenance, and are synthetically sick or lethal with alpha-synuclein"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YGL259W	YPS5 - Protein with similarity to GPI-anchored aspartic proteases such as Yap1p and Yap3p	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YLR046C	YLR046C - Putative membrane protein; member of the fungal lipid-translocating exporter (LTE) family of proteins; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YAL037W	YAL037W - Putative protein of unknown function	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YAL065C	YAL065C - Putative protein of unknown function; has homology to FLO1; possible pseudogene	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YBR063C	YBR063C - Putative protein of unknown function; YBR063C is not an essential gene	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YBR090C	YBR090C - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YBR184W	YBR184W - Putative protein of unknown function; YBR184W is not an essential gene	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YBR285W	YBR285W - Putative protein of unknown function; YBR285W is not an essential gene	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YCL042W	YCL042W - Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YDL211C	YDL211C - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YER186C	YER186C - Putative protein of unknown function	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YFR057W	YFR057W - Putative protein of unknown function	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YGL015C	YGL015C - Putative protein of unknown function; null mutants accumulate cargo in the Golgi	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YGL235W	"YGL235W - Putative protein of unknown function; potential Cdc28p substrate; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YGL260W	YGL260W - Putative protein of unknown function; transcription is significantly increased in a NAP1 deletion background; deletion mutant has increased accumulation of nickel and selenium	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YHR021W-A	"ECM12 - Putative protein of unknown function; may contribute to cell wall biosynthesis, mutants display zymolyase hypersensitivity"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YJL181W	"YJL181W - Putative protein of unknown function; expression is cell-cycle regulated as shown by microarray analysis; potential regulatory target of Mbp1p, which binds to the YJL181W promoter region"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YKL133C	"YKL133C - Putative protein of unknown function; has similarity to Mgr3p, but unlike MGR3, is not required for growth of cells lacking the mitochondrial genome (null mutation does not confer a petite-negative phenotype)"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YKR041W	YKR041W - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YLR030W	YLR030W - Putative protein of unknown function	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YLR031W	YLR031W - Putative protein of unknown function	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YLR053C	YLR053C - Putative protein of unknown function	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YLR125W	YLR125W - Putative protein of unknown function; mutant has decreased Ty3 transposition; YLR125W is not an essential gene	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YLR297W	YLR297W - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YLR297W is not an essential gene; induced by treatment with 8-methoxypsoralen and UVA irradiation	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YLR415C	YLR415C - Putative protein of unknown function; YLR415C is not an essential gene	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YML053C	YML053C - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; overexpression causes a cell cycle delay or arrest; YML053C is not an essential gene	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YML100W-A	"YML100W-A - Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YMR147W	YMR147W - Putative protein of unknown function	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YMR158C-A	"YMR158C-A - Putative protein of unknown function, may contain a lipid attachment site; YMR158C-A is not an essential gene"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YNR014W	"YNR014W - Putative protein of unknown function; expression is cell-cycle regulated, Azf1p-dependent, and heat-inducible"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YOL131W	YOL131W - Putative protein of unknown function	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YOL163W	YOL163W - Putative protein of unknown function; member of the Dal5p subfamily of the major facilitator family	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YOR152C	YOR152C - Putative protein of unknown function; YOR152C is not an essential gene	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YOR214C	YOR214C - Putative protein of unknown function; YOR214C is not an essential gene	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YPL056C	LCL1 - Putative protein of unknown function; deletion mutant is fluconazole resistant and has long chronological lifespan	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YDR210W	YDR210W - Predicted tail-anchored plasma membrane protein containing a conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YER064C	YER064C - Non-essential nuclear protein; null mutation has global effects on transcription	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YCR099C	YCR099C - Putative protein of unknown function	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YGR201C	YGR201C - Putative protein of unknown function	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YMR321C	YMR321C - Putative protein of unknown function; proposed to be a palmitoylated membrane protein	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YGL007C-A	"YGL007C-A - Putative protein of unknown function, identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; deletion exhibits slow-growth phenotype; computationally predicted to have a role in cell budding"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YEL035C	UTR5 - Protein of unknown function; transcription may be regulated by Gcr1p; essential for growth under standard (aerobic) conditions but not under anaerobic conditions	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YBL044W	YBL044W - Putative protein of unknown function; YBL044W is not an essential protein	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YCL021W-A	YCL021W-A - Putative protein of unknown function	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YER076C	"YER076C - Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; analysis of HA-tagged protein suggests a membrane localization"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YNL130C-A	DGR1 - Protein of unknown function; dgr1 null mutant is resistant to 2-deoxy-D-glucose	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YMR084W	YMR084W - Putative protein of unknown function; YMR084W and adjacent ORF YMR085W are merged in related strains	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	Q0075	"AI5_BETA - Protein of unknown function, encoded within an intron of the mitochondrial COX1 gene; translational initiation codon is predicted to be ATA rather than ATG"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YHR050W-A	YHR050W-A - Protein of unknown function; identified by expression profiling and mass spectrometry	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YNR077C	"YNR077C - Protein of unknown function, abundance changes with carbon source"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YAL037C-A	YAL037C-A - Putative protein of unknown function	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YAL063C-A	YAL063C-A - Putative protein of unknown function; identified by expression profiling and mass spectrometry	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YAR035C-A	"YAR035C-A - Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; predicted to have a role in cell budding based on computational ""guilt by association"" analysis"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YBL008W-A	YBL008W-A - Putative protein of unknown function; identified by fungal homology and RT-PCR	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YBL100W-C	"YBL100W-C - Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YBR072C-A	YBR072C-A - Putative protein of unknown function; identified by fungal homology and RT-PCR	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YBR182C-A	"YBR182C-A - Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YBR196C-A	YBR196C-A - Putative protein of unknown function; identified by fungal homology and RT-PCR	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YBR196C-B	YBR196C-B - Putative protein of unknown function; identified by expression profiling and mass spectrometry	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YBR200W-A	YBR200W-A - Putative protein of unknown function; identified by fungal homology and RT-PCR	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YBR201C-A	YBR201C-A - Putative protein of unknown function	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YBR221W-A	YBR221W-A - Putative protein of unknown function; identified by expression profiling and mass spectrometry	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YBR230W-A	YBR230W-A - Putative protein of unknown function	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YBR296C-A	"YBR296C-A - Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YBR298C-A	"YBR298C-A - Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YCL001W-B	YCL001W-B - Putative protein of unknown function; YCL001W-B gene has similarity to DOM34 and is present in a region duplicated between chromosomes XIV and III	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YCR024C-B	YCR024C-B - Putative protein of unknown function; identified by expression profiling and mass spectrometry	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YCR095W-A	YCR095W-A - Putative protein of unknown function	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YCR108C	YCR108C - Putative protein of unknown function; identified by fungal homology and RT-PCR	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YDL007C-A	YDL007C-A - Putative protein of unknown function	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YDL159W-A	YDL159W-A - Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YDR003W-A	YDR003W-A - Putative protein of unknown function; identified by expression profiling and mass spectrometry	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YDR034C-A	YDR034C-A - Putative protein of unknown function; contained within the solo Ty1 LTR element YDRWdelta7	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YDR119W-A	YDR119W-A - Putative protein of unknown function; may interact with respiratory chain complexes III (ubiquinol-cytochrome c reductase) or IV (cytochrome c oxidase)	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YDR169C-A	YDR169C-A - Putative protein of unknown function; identified by fungal homology and RT-PCR	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YDR182W-A	YDR182W-A - Putative protein of unknown function; identified by fungal homology and RT-PCR	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YDR194W-A	YDR194W-A - Putative protein of unknown function; identified by fungal homology and RT-PCR	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YDR246W-A	YDR246W-A - Putative protein of unknown function; identified by fungal homology and RT-PCR	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YDR366C	YDR366C - Putative protein of unknown function	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YDR374W-A	YDR374W-A - Putative protein of unknown function	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YDR461C-A	YDR461C-A - Putative protein of unknown function	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YDR524W-C	YDR524W-C - Putative protein of unknown function; small ORF identified by SAGE; deletion strains are moderately sensitive to the radiomimetic drug bleomycin	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YER053C-A	YER053C-A - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YER078W-A	YER078W-A - Putative protein of unknown function; identified by fungal homology and RT-PCR	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YER175W-A	"YER175W-A - Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YFL041W-A	YFL041W-A - Putative protein of unknown function; identified by fungal homology and RT-PCR	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YFR012W-A	YFR012W-A - Putative protein of unknown function; identified by homology	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YFR032C-B	"YFR032C-B - Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YGL006W-A	YGL006W-A - Putative protein of unknown function; identified by SAGE	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YGL258W-A	YGL258W-A - Putative protein of unknown function	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YGR035W-A	YGR035W-A - Putative protein of unknown function	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YGR121W-A	YGR121W-A - Putative protein of unknown function	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YGR146C-A	YGR146C-A - Putative protein of unknown function	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YGR161W-C	YGR161W-C - Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YGR174W-A	"YGR174W-A - Putative protein of unknown function; predicted to have a role in cell budding based on computational ""guilt by association"" analysis"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YGR204C-A	"YGR204C-A - Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YGR240C-A	YGR240C-A - Putative protein of unknown function; identified by fungal homology and RT-PCR	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YHL015W-A	YHL015W-A - Putative protein of unknown function	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YHL048C-A	YHL048C-A - Putative protein of unknown function; identified by expression profiling and mass spectrometry	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YHR007C-A	YHR007C-A - Putative protein of unknown function; identified by expression profiling and mass spectrometry	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YHR022C-A	"YHR022C-A - Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YHR086W-A	YHR086W-A - Putative protein of unknown function; identified by fungal homology and RT-PCR	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YHR175W-A	YHR175W-A - Putative protein of unknown function; identified by fungal homology and RT-PCR	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YHR213W-A	"YHR213W-A - Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YHR214C-D	"YHR214C-D - Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YHR214C-E	"YHR214C-E - Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YIL002W-A	YIL002W-A - Putative protein of unknown function; identified by expression profiling and mass spectrometry	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YIL046W-A	YIL046W-A - Putative protein of unknown function; identified by expression profiling and mass spectrometry	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YIL134C-A	YIL134C-A - Putative protein of unknown function; identified by fungal homology and RT-PCR	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YIR018C-A	YIR018C-A - Putative protein of unknown function; identified by expression profiling and mass spectrometry	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YIR021W-A	YIR021W-A - Putative protein of unknown function; identified by expression profiling and mass spectrometry	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YJL047C-A	YJL047C-A - Putative protein of unknown function	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YJL052C-A	"YJL052C-A - Putative protein of unknown function, identified based on comparison to related yeast species"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YJL077W-B	"YJL077W-B - Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YJR151W-A	"YJR151W-A - Putative protein of unknown function; identified by fungal homology and RT-PCR; predicted to have a role in transcription based on computational ""guilt by association"" analysis"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YKL023C-A	YKL023C-A - Putative protein of unknown function	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YKL065W-A	YKL065W-A - Putative protein of unknown function	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YKL068W-A	YKL068W-A - Putative protein of unknown function; identified by homology to <i>Ashbya gossypii</i>	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YKL106C-A	YKL106C-A - Putative protein of unknown function; identified by homology to uncharacterized proteins in other fungi	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YKL183C-A	YKL183C-A - Putative protein of unknown function; identified by fungal homology and RT-PCR	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YLL006W-A	YLL006W-A - Putative protein of unknown function; identified by fungal homology and RT-PCR	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YLR146W-A	YLR146W-A - Putative protein of unknown function	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YLR154C-G	YLR154C-G - Putative protein of unknown function identified by fungal homology comparisons and RT-PCR; this ORF is contained within RDN25-2 and RDN37-2	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YLR264C-A	YLR264C-A - Putative protein of unknown function	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YLR285C-A	YLR285C-A - Putative protein of unknown function; identified by fungal homology and RT-PCR	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YLR307C-A	YLR307C-A - Putative protein of unknown function	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YLR342W-A	YLR342W-A - Putative protein of unknown function	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YLR361C-A	YLR361C-A - Putative protein of unknown function	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YLR406C-A	YLR406C-A - Putative protein of unknown function	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YLR412C-A	YLR412C-A - Putative protein of unknown function	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YML007C-A	YML007C-A - Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YML054C-A	YML054C-A - Putative protein of unknown function	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YMR001C-A	YMR001C-A - Putative protein of unknown function	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YMR030W-A	YMR030W-A - Putative protein of unknown function	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YMR105W-A	YMR105W-A - Putative protein of unknown function	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YMR175W-A	YMR175W-A - Putative protein of unknown function	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YMR182W-A	YMR182W-A - Putative protein of unknown function	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YMR230W-A	YMR230W-A - Putative protein of unknown function	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YMR247W-A	YMR247W-A - Putative protein of unknown function	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YMR315W-A	YMR315W-A - Putative protein of unknown function	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YNL042W-B	YNL042W-B - Putative protein of unknown function	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YNL067W-B	YNL067W-B - Putative protein of unknown function	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YNL097C-B	YNL097C-B - Putative protein of unknown function	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YNL146C-A	YNL146C-A - Putative protein of unknown function	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YNL277W-A	YNL277W-A - Putative protein of unknown function	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YNR034W-A	YNR034W-A - Putative protein of unknown function; expression is regulated by Msn2p/Msn4p	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YOL038C-A	YOL038C-A - Putative protein of unknown function; identified by SAGE analysis	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YOL097W-A	YOL097W-A - Putative protein of unknown function; identified by expression profiling and mass spectrometry	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YOL155W-A	YOL155W-A - Putative protein of unknown function; identified by expression profiling and mass spectrometry	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YOL159C-A	YOL159C-A - Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YOL164W-A	YOL164W-A - Putative protein of unknown function; identified by fungal homology and RT-PCR	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YOR011W-A	YOR011W-A - Putative protein of unknown function	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YOR034C-A	YOR034C-A - Putative protein of unknown function; identified by expression profiling and mass spectrometry	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YOR293C-A	YOR293C-A - Putative protein of unknown function; identified by expression profiling and mass spectrometry	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YOR316C-A	YOR316C-A - Putative protein of unknown function; identified by fungal homology and RT-PCR	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YOR376W-A	YOR376W-A - Putative protein of unknown function; identified by fungal homology and RT-PCR	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YOR381W-A	YOR381W-A - Putative protein of unknown function; identified by fungal homology and RT-PCR	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YPL038W-A	YPL038W-A - Putative protein of unknown function; identified by fungal homology and RT-PCR	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YPL119C-A	YPL119C-A - Putative protein of unknown function; identified by expression profiling and mass spectrometry	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YPL278C	YPL278C - Putative protein of unknown function; gene expression regulated by copper levels	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YPR108W-A	YPR108W-A - Putative protein of unknown function; identified by fungal homology and RT-PCR	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YPR145C-A	YPR145C-A - Putative protein of unknown function	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YAL064W-B	YAL064W-B - Fungal-specific protein of unknown function	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YAR068W	YAR068W - Fungal-specific protein of unknown function; induced in respiratory-deficient cells	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	Q0255	Q0255 - Maturase-like protein	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YGL193C	"YGL193C - Haploid-specific gene repressed by a1-alpha2, turned off in sir3 null strains, absence enhances the sensitivity of rad52-327 cells to campothecin almost 100-fold"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YJL136W-A	"YJL136W-A - Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; identified by SAGE"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YMR272W-B	"YMR272W-B - Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YOL019W-A	"YOL019W-A - Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YOR032W-A	"YOR032W-A - Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YOR161C-C	"YOR161C-C - Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YOR394C-A	"YOR394C-A - Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YPL152W-A	"YPL152W-A - Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YPR159C-A	"YPR159C-A - Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YDL133C-A	"RPL41B - Ribosomal protein L47 of the large (60S) ribosomal subunit, identical to Rpl41Ap and has similarity to rat L41 ribosomal protein; comprised of only 25 amino acids; rpl41a rpl41b double null mutant is viable"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YER014C-A	BUD25 - Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YGL168W	HUR1 - Protein of unknown function; reported null mutant phenotype of hydroxyurea sensitivity may be due to effects on overlapping PMR1 gene	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YIR021W	"MRS1 - Protein required for the splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YDL069C	"CBS1 - Mitochondrial translational activator of the COB mRNA; membrane protein that interacts with translating ribosomes, acts on the COB mRNA 5'-untranslated leader"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YAL056W	"GPB2 - Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; inhibits Ras activity through direct interactions with Ira1p/2p; regulated by G-alpha protein Gpa2p; homolog of Gpb1p"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YBR107C	"IML3 - Protein with a role in kinetochore function, localizes to the outer kinetochore in a Ctf19p-dependent manner, interacts with Chl4p and Ctf19p"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YDR351W	SBE2 - Protein involved in the transport of cell wall components from the Golgi to the cell surface; required for bud growth	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YOR189W	IES4 - Component of the INO80 chromatiin remodeling complex and target of the Mec1p/Tel1p DNA damage signaling pathway; proposed to link chromatin remodeling to replication checkpoint responses	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YLL049W	"LDB18 - Component of the dynactin complex, which is required for dynein activity; null mutant exhibits defects in nuclear migration and spindle orientation and has reduced affinity for alcian blue dye; has homology to mammalian dynactin subunit p24"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YCL058C	FYV5 - Protein involved in regulation of the mating pathway; binds with Matalpha2p to promoters of haploid-specific genes; required for survival upon exposure to K1 killer toxin; involved in ion homeostasis	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YPL049C	"DIG1 - MAP kinase-responsive inhibitor of the Ste12p transcription factor, involved in the regulation of mating-specific genes and the invasive growth pathway; related regulators Dig1p and Dig2p bind to Ste12p"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YPL017C	"IRC15 - Microtubule associated protein; regulates microtubule dynamics; required for accurate meiotic chromosome segregation; null mutant displays large budded cells due to delayed mitotic progression, increased levels of spontaneous Rad52 foci"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YLR233C	EST1 - TLC1 RNA-associated factor involved in telomere length regulation as recruitment subunit of telomerase; has G-quadruplex promoting activity that is required for telomere elongation; possible role in activating telomere-bound Est2p-TLC1-RNA	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YKL096W-A	"CWP2 - Covalently linked cell wall mannoprotein, major constituent of the cell wall; plays a role in stabilizing the cell wall; involved in low pH resistance; precursor is GPI-anchored"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YLR313C	"SPH1 - Protein involved in shmoo formation and bipolar bud site selection; homologous to Spa2p, localizes to sites of polarized growth in a cell cycle dependent- and Spa2p-dependent manner, interacts with MAPKKs Mkk1p, Mkk2p, and Ste7p"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YLR442C	"SIR3 - Silencing protein that interacts with Sir2p and Sir4p, and histone H3 and H4 tails, to establish a transcriptionally silent chromatin state; required for spreading of silenced chromatin; recruited to chromatin through interaction with Rap1p"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YOL052C-A	"DDR2 - Multistress response protein, expression is activated by a variety of xenobiotic agents and environmental or physiological stresses"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YOR068C	VAM10 - Protein involved in vacuole morphogenesis; acts at an early step of homotypic vacuole fusion that is required for vacuole tethering	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YBR150C	"TBS1 - Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YGR154C	GTO1 - Omega-class glutathione transferase; induced under oxidative stress; putative peroxisomal localization	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YPR030W	"CSR2 - Nuclear protein proposed to regulate utilization of nonfermentable carbon sources and endocytosis of plasma membrane proteins; overproduction suppresses chs5 spa2 lethality at high temp; ubiquitinated by Rsp5p, deubiquitinated by Ubp2p"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YER096W	"SHC1 - Sporulation-specific activator of Chs3p (chitin synthase III), required for the synthesis of the chitosan layer of ascospores; has similarity to Skt5p, which activates Chs3p during vegetative growth; transcriptionally induced at alkaline pH"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YPL192C	PRM3 - Pheromone-regulated protein required for nuclear envelope fusion during karyogamy; localizes to the outer face of the nuclear membrane; interacts with Kar5p at the spindle pole body	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YOL091W	"SPO21 - Component of the meiotic outer plaque of the spindle pole body, involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YGR146C	"ECL1 - Protein of unknown function, affects chronological lifespan; induced by iron homeostasis transcription factor Aft2p; multicopy suppressor of temperature sensitive hsf1 mutant; induced by treatment with 8-methoxypsoralen and UVA irradiation"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YER028C	"MIG3 - Probable transcriptional repressor involved in response to toxic agents such as hydroxyurea that inhibit ribonucleotide reductase; phosphorylation by Snf1p or the Mec1p pathway inactivates Mig3p, allowing induction of damage response genes"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YDR281C	"PHM6 - Protein of unknown function, expression is regulated by phosphate levels"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YLR273C	PIG1 - Putative targeting subunit for the type-1 protein phosphatase Glc7p that tethers it to the Gsy2p glycogen synthase	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YHR003C	"YHR003C - Protein of unknown function, localized to the mitochondrial outer membrane"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YJL028W	"YJL028W - Protein of unknown function; may interact with ribosomes, based on co-purification experiments"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YJR120W	"YJR120W - Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YML101C	"CUE4 - Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YMR040W	"YET2 - Protein of unknown function that may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YMR251W-A	HOR7 - Protein of unknown function; overexpression suppresses Ca2+ sensitivity of mutants lacking inositol phosphorylceramide mannosyltransferases Csg1p and Csh1p; transcription is induced under hyperosmotic stress and repressed by alpha factor	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YPR096C	"YPR096C - Protein of unknown function that may interact with ribosomes, based on co-purification experiments"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YPR158W	CUR1 - Protein of unknown function involved in destabilization of [URE3] prions; similar in sequence to Btn2p	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YOL159C	YOL159C - Soluble protein of unknown function; deletion mutants are viable and have elevated levels of Ty1 retrotransposition and Ty1 cDNA	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YFR026C	ULI1 - Putative protein of unknown function involved in and induced by the endoplasmic reticulum unfolded protein response	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YDR251W	"PAM1 - Essential protein of unknown function; exhibits variable expression during colony morphogenesis; overexpression permits survival without protein phosphatase 2A, inhibits growth, and induces a filamentous phenotype"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YOR284W	HUA2 - Cytoplasmic protein of unknown function; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YBR050C	"REG2 - Regulatory subunit of the Glc7p type-1 protein phosphatase; involved with Reg1p, Glc7p, and Snf1p in regulation of glucose-repressible genes, also involved in glucose-induced proteolysis of maltose permease"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YDL184C	"RPL41A - Ribosomal protein L47 of the large (60S) ribosomal subunit, identical to Rpl41Bp and has similarity to rat L41 ribosomal protein; comprised of only 25 amino acids; rpl41a rpl41b double null mutant is viable"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YDL197C	ASF2 - Anti-silencing protein that causes derepression of silent loci when overexpressed	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YDR096W	"GIS1 - JmjC domain-containing histone demethylase and transcription factor; involved in expression of genes during nutrient limitation; negatively regulates DPP1 and PHR1; activity is modulated by limited proteasome-mediated proteolysis; has a JmjC and a JmjN domain in the N-terminal region that interact, promoting Gis1p stability and proper transcriptional activity; contains transactivating domains TAD1 and TAD2 downstream of the Jmj domains and a C-terminal DNA binding domain"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YDR252W	BTT1 - Beta3 subunit of the heterotrimeric nascent polypeptide-associated complex which binds ribosomes via its beta-subunits in close proximity to nascent polypeptides; interacts with Caf130p of the CCR4-NOT complex; similar to human BTF3	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YDR273W	"DON1 - Meiosis-specific component of the spindle pole body, part of the leading edge protein (LEP) coat, forms a ring-like structure at the leading edge of the prospore membrane during meiosis II"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YFL010W-A	"AUA1 - Protein required for the negative regulation by ammonia of Gap1p, which is a general amino acid permease"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YGL089C	"MF(ALPHA)2 - Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)1, which is more highly expressed than MF(ALPHA)2"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YGL158W	RCK1 - Protein kinase involved in the response to oxidative stress; identified as suppressor of S. pombe cell cycle checkpoint mutations	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YGL170C	"SPO74 - Component of the meiotic outer plaque of the spindle pole body, involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YGL229C	"SAP4 - Protein required for function of the Sit4p protein phosphatase, member of a family of similar proteins that form complexes with Sit4p, including Sap155p, Sap185p, and Sap190p"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YGR004W	"PEX31 - Peroxisomal integral membrane protein, involved in negative regulation of peroxisome size; partially functionally redundant with Pex30p and Pex32p; probably acts at a step downstream of steps mediated by Pex28p and Pex29p"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YHR153C	SPO16 - Meiosis-specific protein involved in synaptonemal complex assembly; implicated in regulation of crossover formation; required for sporulation	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YHR157W	REC104 - Protein involved in early stages of meiotic recombination; required for meiotic crossing over; forms a complex with Rec102p and Spo11p necessary during the initiation of recombination	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YJL116C	NCA3 - Protein that functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p ) of the Fo-F1 ATP synthase; member of the SUN family; expression induced in cells treated with the mycotoxin patulin	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YKR077W	"MSA2 - Putative transcriptional activator, that interacts with G1-specific transcription factor, MBF and G1-specific promoters; ortholog of Msa2p, an MBF and SBF activator that regulates G1-specific transcription and cell cycle initiation"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YKR098C	UBP11 - Ubiquitin-specific protease that cleaves ubiquitin from ubiquitinated proteins	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YKR101W	"SIR1 - Protein involved in repression of transcription at the silent mating-type loci HML and HMR; recruitment to silent chromatin requires interactions with Orc1p and with Sir4p, through a common Sir1p domain; binds to centromeric chromatin"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YKR104W	YKR104W - Putative transporter of the multidrug resistance-associated protein (MRP) subfamily; contains a stop codon in S288C; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YLL046C	RNP1 - Ribonucleoprotein that contains two RNA recognition motifs (RRM)	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YLL052C	"AQY2 - Water channel that mediates the transport of water across cell membranes, only expressed in proliferating cells, controlled by osmotic signals, may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YLR266C	"PDR8 - Transcription factor; targets include ATP-binding cassette (ABC) transporters, major facilitator superfamily transporters, and other genes involved in the pleiotropic drug resistance (PDR) phenomenon"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YLR453C	RIF2 - Protein that binds to the Rap1p C-terminus and acts synergistically with Rif1p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YML047C	"PRM6 - Pheromone-regulated protein, predicted to have 2 transmembrane segments; regulated by Ste12p during mating"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YMR017W	"SPO20 - Meiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YMR174C	"PAI3 - Cytoplasmic proteinase A (Pep4p) inhibitor, dependent on Pbs2p and Hog1p protein kinases for osmotic induction; intrinsically unstructured, N-terminal half becomes ordered in the active site of proteinase A upon contact"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YMR180C	"CTL1 - RNA 5'-triphosphatase, localizes to both the nucleus and cytoplasm"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YMR192W	"GYL1 - Putative GTPase activating protein (GAP) that may have a role in polarized exocytosis; stimulates Gyp5p GAP activity on Ypt1p, colocalizes with Gyp5p at sites of polarized growth; interacts with Gyp5p, Rvs161p, and Rvs167p"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YNR028W	"CPR8 - Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; similarity to Cpr4p suggests a potential role in the secretory pathway"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YOL128C	"YGK3 - Protein kinase related to mammalian glycogen synthase kinases of the GSK-3 family; GSK-3 homologs (Mck1p, Rim11p, Mrk1p, Ygk3p) are involved in control of Msn2p-dependent transcription of stress responsive genes and in protein degradation"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YOR179C	"SYC1 - Subunit of the APT subcomplex of cleavage and polyadenylation factor, may have a role in 3' end formation of both polyadenylated and non-polyadenylated RNAs"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YOR193W	"PEX27 - Peripheral peroxisomal membrane protein involved in controlling peroxisome size and number, interacts with homologous protein Pex25p"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YOR324C	"FRT1 - Tail-anchored ER membrane protein that is a substrate of the phosphatase calcineurin; interacts with homolog Frt2p; promotes cell growth in stress conditions, possibly via a role in posttranslational translocation"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YBR052C	RFS1 - Protein of unknown function; member of a flavodoxin-like fold protein family that includes Pst2p and Ycp4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YDR275W	"BSC2 - Protein of unknown function, ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YER115C	"SPR6 - Protein of unknown function, expressed during sporulation; not required for sporulation, but gene exhibits genetic interactions with other genes required for sporulation"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YJL077C	"ICS3 - Protein of unknown function; may play a role in vacuolar sorting, null mutants are hypersensitive to sortin2"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YLR082C	SRL2 - Protein of unknown function; overexpression suppresses the lethality caused by a rad53 null mutation	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YNR069C	"BSC5 - Protein of unknown function, ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YPL027W	SMA1 - Protein of unknown function involved in the assembly of the prospore membrane during sporulation; interacts with Spo14p	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YOL015W	IRC10 - Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YBL005W	"PDR3 - Transcriptional activator of the pleiotropic drug resistance network, regulates expression of ATP-binding cassette (ABC) transporters through binding to cis-acting sites known as PDREs (PDR responsive elements)"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YBL054W	"TOD6 - PAC motif binding protein involved in rRNA and ribosome biogenesis; subunit of the RPD3L histone deacetylase complex; Myb-like HTH transcription factor, similar to Dot6p; hypophosphorylated by rapamycin treatment in a Sch9p-dependent manne"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YBR240C	"THI2 - Zinc finger protein of the Zn(II)2Cys6 type, probable transcriptional activator of thiamine biosynthetic genes"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YDL214C	"PRR2 - Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor; mutant has increased aneuploidy tolerance"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YDR223W	CRF1 - Transcriptional corepressor involved in repression of ribosomal protein (RP) gene transcription via the TOR signaling pathway which promotes accumulation of Crf1p in the nucleus; role in repression of RP genes varies by strain	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YDR528W	"HLR1 - Protein involved in regulation of cell wall composition and integrity and response to osmotic stress; overproduction suppresses a lysis sensitive PKC mutation; similar to Lre1p, which functions antagonistically to protein kinase A"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YER035W	"EDC2 - RNA-binding protein, activates mRNA decapping directly by binding to the mRNA substrate and enhancing the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YGR221C	TOS2 - Protein involved in localization of Cdc24p to the site of bud growth; may act as a membrane anchor; localizes to the bud neck and bud tip; potentially phosphorylated by Cdc28p	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YHR014W	"SPO13 - Meiosis-specific protein, involved in maintaining sister chromatid cohesion during meiosis I as well as promoting proper attachment of kinetochores to the spindle during meiosis I and meiosis II"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YHR015W	"MIP6 - Putative RNA-binding protein, interacts with Mex67p, which is a component of the nuclear pore involved in nuclear mRNA export"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YHR136C	SPL2 - Protein with similarity to cyclin-dependent kinase inhibitors; downregulates low-affinity phosphate transport during phosphate limitation; overproduction suppresses a plc1 null mutation; GFP-fusion protein localizes to the cytoplasm	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YHR139C	SPS100 - Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall; expression also induced in cells treated with the mycotoxin patulin	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YHR160C	PEX18 - Peroxin required for targeting of peroxisomal matrix proteins containing PTS2; interacts with Pex7p; partially redundant with Pex21p	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YIL037C	"PRM2 - Pheromone-regulated protein, predicted to have 4 transmembrane segments and a coiled coil domain; regulated by Ste12p; required for efficient nuclear fusion"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YJL144W	"YJL144W - Cytoplasmic hydrophilin with a role in dessication resistance; expression induced by osmotic stress, starvation and during stationary phase; GFP-fusion protein is induced by the DNA-damaging agent MMS"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YJR147W	HMS2 - Protein with similarity to heat shock transcription factors; overexpression suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YKL132C	"RMA1 - Putative dihydrofolate synthetase; has similarity to Fol3p and to E. coli folylpolyglutamate synthetase/dihydrofolate synthetase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YKL161C	KDX1 - Protein kinase implicated in the Slt2p mitogen-activated (MAP) kinase signaling pathway; interacts with numerous components in the mating pheromone and CWI MAPK pathways; associates with Rlm1p	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YKL168C	KKQ8 - Putative serine/threonine protein kinase with unknown cellular role	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YKR091W	"SRL3 - Cytoplasmic protein that, when overexpressed, suppresses the lethality of a rad53 null mutation; potential Cdc28p substrate"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YMR030W	RSF1 - Protein required for respiratory growth; localized to both the nucleus and mitochondrion; may interact with transcription factors to mediate the transition to respiratory growth and activate transcription of nuclear and mitochondrial genes	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YMR056C	"AAC1 - Mitochondrial inner membrane ADP/ATP translocator, exchanges cytosolic ADP for mitochondrially synthesized ATP; phosphorylated; Aac1p is a minor isoform while Pet9p is the major ADP/ATP translocator"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YMR175W	SIP18 - Phospholipid-binding hydrophilin with a role in dessication resistance; expression is induced by osmotic stress	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YOL101C	"IZH4 - Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family, expression induced by fatty acids and altered zinc levels; deletion reduces sensitivity to excess zinc; possible role in sterol metabolism"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YOL158C	"ENB1 - Endosomal ferric enterobactin transporter, expressed under conditions of iron deprivation; member of the major facilitator superfamily; expression is regulated by Rcs1p and affected by chloroquine treatment"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YOR009W	TIR4 - Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth; transcription is also induced by cold shock	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YOR177C	"MPC54 - Component of the meiotic outer plaque, a membrane-organizing center which is assembled on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane; potential Cdc28p substrate"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YPL021W	"ECM23 - Non-essential protein of unconfirmed function; affects pre-rRNA processing, may act as a negative regulator of the transcription of genes involved in pseudohyphal growth; homologous to Srd1p"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YPL200W	CSM4 - Protein required for accurate chromosome segregation during meiosis; involved in meiotic telomere clustering (bouquet formation) and telomere-led rapid prophase movements	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YIL158W	AIM20 - Putative protein of unknown function; overexpression causes a cell cycle delay or arrest; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; null mutant displays elevated frequency of mitochondrial genome loss	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YPL053C	KTR6 - Probable mannosylphosphate transferase involved in the synthesis of core oligosaccharides in protein glycosylation pathway; member of the KRE2/MNT1 mannosyltransferase family	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YPR005C	"HAL1 - Cytoplasmic protein involved in halotolerance; decreases intracellular Na+ (via Ena1p) and increases intracellular K+ by decreasing efflux; expression repressed by Ssn6p-Tup1p and Sko1p and induced by NaCl, KCl, and sorbitol through Gcn4p"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YNL269W	"BSC4 - Protein of unknown function, ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; readthrough is increased upon depletion of Sup35p"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YML058W-A	"HUG1 - Protein involved in the Mec1p-mediated checkpoint pathway that responds to DNA damage or replication arrest, transcription is induced by DNA damage"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YHR199C-A	"NBL1 - Subunit of the conserved chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), which regulates mitotic chromosome segregation; not required for the kinase activity of the complex; mediates the interaction of Sli15p and Bir1p"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YLR010C	TEN1 - Protein that regulates telomeric length; protects telomeric ends in a complex with Cdc13p and Stn1p	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YNL188W	"KAR1 - Essential protein involved in karyogamy during mating and in spindle pole body duplication during mitosis, localizes to the half-bridge of the spindle pole body, interacts with Spc72p during karyogamy, also interacts with Cdc31p"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YOR076C	SKI7 - Coupling protein that mediates interactions between the Ski complex and the cytoplasmic exosome during 3'-5' RNA degradation; eRF3-like domain targets nonstop mRNA for degradation; null mutants have superkiller phenotype	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YKL037W	AIM26 - Putative protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss; null mutation confers sensitivity to tunicamycin and DTT	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YJL118W	"YJL118W - Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; YJL18W is a non-essential gene; deletion enhances the toxicity of heterologously expressed human alpha-synuclein"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YKR078W	"YKR078W - Cytoplasmic protein of unknown function, has similarity to Vps5p; potential Cdc28p substrate; contains a Phox homology (PX) domain and specifically binds phosphatidylinositol 3-phosphate (PtdIns-3-P)"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YGR031C-A	NAG1 - Protein involved in yeast cell wall biogenesis; localizes to the cell periphery; production of Nag1p is dependent upon the presence of Slt2p and Rlm1p; gene is nested within and antisense to IMO32	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YMR081C	"ISF1 - Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	R0010W	"FLP1 - Site-specific recombinase encoded on the 2-micron plasmid, required for 2-micron plasmid propagation as part of a plasmid amplification system that compensates for any copy number decreases caused by missegregation events"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YLR154C	"RNH203 - Ribonuclease H2 subunit, required for RNase H2 activity; related to human AGS3 that causes Aicardi-Goutieres syndrome"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YAL064W	"YAL064W - Protein of unknown function; may interact with ribosomes, based on co-purification experiments"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YBL108C-A	"PAU9 - Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YPR036W-A	YPR036W-A - Protein of unknown function; transcription is regulated by Pdr1p	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	YLR162W	"YLR162W - Putative protein of unknown function; overexpression confers resistance to the antimicrobial peptide MiAMP1 and causes growth arrest, apoptosis, and increased sensitivity to cobalt chloride"	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	R0020C	REP1 - Master regulator that acts in concert with Rep2p to regulate transcript levels of the FLP1 gene that promotes plasmid copy amplification; autoregulates levels of its own transcript	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	R0030W	RAF1 - Anti-repressor that increases 2 micron plasmid copy number by relieving repression of the FLP1 site-specific recombinase caused by the Rep1-Rep2p trascription regulator; also itself repressed by the Rep1p-Rep2p complex	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A
#N/A	R0040C	REP2 - Master regulator that acts in concert with Rep1p to regulate transcript levels of the FLP1 gene that promotes plasmid copy amplification; also autoregulates levels of its own transcript	1	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A	#N/A